Digital Commons Network^™

Heat Misers, Snow Misers, And Cognitive Misers: The 'Nukewarm' Perceptions Of Nuclear Power, Tyler Williams

Dissertations and Theses

Rising energy demand in the United States necessitates alternatives to fossil fuels, yet renewable energy sources alone are insufficient to meet this demand. Nuclear power presents a promising option but faces persistent public hesitancy. This study examines how heuristic-based biases relate to American's risk-benefit perceptions towards nuclear power. Guided by the heuristic-systematic model. Results indicate that competence and affect are related to risk-benefit perceptions, and naturalness shows no relationship with risk perceptions but does correlate with benefit perceptions. Implications highlight the importance of affect-driven communication strategies for nuclear communicators, while also underscoring the need for participatory approaches that foster trust …

Optimizing Kidney Allograft Years: Underutilization Of Pediatric Donors, Nicholas Herrera, Ana Cortez, Diane Cibrik, Bradley A. Warady

Manuscripts, Articles, Book Chapters and Other Papers

Background. 

The Kidney Donor Profile Index (KDPI) score drives kidney allocation in the United States for both adult and pediatric donors, despite the calculation being primarily derived from adult donor data. A KDPI of ≤20% is considered to have the longest graft survival potential and is typically prioritized for recipients who have a low Estimated Posttransplant Survival (EPTS) score. Using KDPI to assess pediatric donor quality may underestimate graft survival and result in underutilization of these kidneys for recipients with a low EPTS score.

Methods. 

Using Scientific Registry of Transplant Recipients data, we analyzed 5-y posttransplant death-censored graft survival of …

Analysis Of Environmental Site Assessments Of Brownfield Redevelopment In Waterloo, Iowa, Sage Cappi

Dissertations and Theses @ UNI

This thesis examines how Environmental Site Assessments (ESAs) are interpreted and utilized in the context of Brownfield redevelopment, with particular attention to the relationship between historical context, contamination, health risk, and future redevelopment possibilities. While ESAs are widely used to inform redevelopment decisions, there remains a gap in understanding how reported environmental data translates into meaningful assessments. To address this, this study analyzes historical and environmental data from six Brownfield sites, identifying documented contaminants, their associated carcinogenic group, and redevelopment potential. Central to this research is the development of a relational framework designed to function as a more approachable interpretive …

From The Goodness Of Our Hearts: A Scoping Review Of Qualitative Literature On Altruism As A Reward Mechanism For Nursing, Jacqueline Christianson, Madaline Mccarthy, Bonnie Sommers-Olson, Emily Horner, Norah L. Johnson

College of Nursing Faculty Research and Publications

Introduction

Altruism, the desire to help others, is a common motivation for choosing a career in nursing. Improved understanding of the role of altruism as a reward or motivation for currently-practicing nurses may inform future interventions to improve effort-reward balance among practicing nurses. Therefore, the purpose of this study was to collect, examine, and present literature on how altruism has been described as a reward mechanism or motivation for engaging in professional nursing.

Methods

This scoping review of literature used the Arksey & O’Malley method, PRISMA-ScR reporting checklist, and Rayyan review management platform. PubMed, Web of Science, and CINAHL were …

Pharmacogenetic Hslco1b1*14-Guided Dosing Of Methotrexate In Transgenic Arthritic Mice Normalizes Exposure And Response., Felicia Gooden, Brennan D. Meier, Griffin D. Shaffer, Kim Gibson, Paul Toren, Nieko C. Punt, Sandhya Subash, Dilip K. Singh, Bhagwat Prasad, Laura Ramsey, Zachary L. Taylor

Manuscripts, Articles, Book Chapters and Other Papers

Juvenile idiopathic arthritis (JIA) is a chronic autoimmune disease that negatively affects ~100,000 children under the age of 16 in the United States. About ~30% of these patients fail first-line drug therapy with low-dose methotrexate (MTX) due to poor tolerability or lack of efficacy. The SLCO1B1*14 allele is associated with increased MTX clearance and has been linked to reduced overall drug exposure and nonresponse to MTX in JIA patients. Herein, we describe transgenic hSLCO1B1*14 and hSLCO1B1*1 DBA1/J mSlco1b2 knock-out mice, which we used to assess arthritic response to MTX using the collagen-induced arthritis model. Mass spectrometry-based proteomics analysis revealed that …

Association Of N-Terminal Pro-Brain Natriuretic Peptide With Ckd Progression In The Ckd In Children Study., Alexander Kula, David K. Prince, Joseph T. Flynn, Susan L. Furth, Bradley A. Warady, Tamara Isakova, Derek Ng, Jeese Seegmiller, Rob Christenson, Nisha Bansal

Manuscripts, Articles, Book Chapters and Other Papers

No abstract provided.

Botox Detection And Face Analytics Using Deep Learning, Audison Beaubrun, Gabriella Pangelinan, Michael King

Electrical Engineering and Computer Science Faculty Publications

Non-surgical cosmetic procedures like Botox are increasingly common, yet their impact on facial analytics systems remains unexplored. We curate a novel dataset of 1,990 before-and-after images from 390 individuals who received cosmetic injectables. Using this dataset, we demonstrate that these subtle facial modifications measurably affect age estimation: FairFace and FaceXFormer show statistically significant shifts toward younger age estimates (-1.43 and-3.27 years, p <0.05), while MiVOLO remains stable. We also show these modifications are detectable: training deep learning models (ResNet-50, DenseNet-121, ConvNeXt-Tiny) to classify cosmetically-altered faces achieves up to 89% accuracy. Our findings reveal that even minor, non-surgical facial changes can bias age-based analytics and are algorithmically detectable-raising critical concerns for privacy, fairness, and robustness as facial analytics expand into high-stakes domains like insurance, hiring, and health assessment. © 2026, Florida Online Journals, University of Florida. All rights reserved.

Indirect Treatment Comparison Of Tezepelumab Versus Other Biologics In Severe Chronic Rhinosinusitis With Nasal Polyps: A Systematic Literature Review And Network Meta-Analysis, Joseph K. Han, Joaquim Mullol, Claire Hopkins, Oliver Pfaar, Martin Desrosiers, Jason Steenkamp, Danny Gibson, Santiago Zuluaga Sanchez, Andrew Foster, Christopher S. Ambrose

Department of Otolaryngology (ENT) Faculty Publications

Introduction

This study compared the efficacy of tezepelumab with other approved biologics and endoscopic sinus surgery (ESS) using indirect treatment comparisons (ITCs) in adults with severe, uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP).

Methods

Randomized controlled trials (RCTs) identified via a systematic literature review (SLR) were synthesized in a network meta-analysis (NMA). Outcomes included change from baseline in nasal polyp score (NPS), nasal congestion/obstruction score (NCS/NOS), difficulty with sense of smell (DSS), Sino-Nasal Outcome Test-22 (SNOT-22) score, Lund Mackay score (LMS), time to nasal polyposis (NP) surgery decision, proportions requiring NP surgery or systemic corticosteroids (SCS), time to SCS use, …

Expanding The Genetic And Phenotypic Spectrum Of Polrmt-Related Mitochondrial Disease., Mahmoud R. Fassad, Sebastian Valenzuela, Monika Oláhová, Jack J. Collier, Charlotte V Y Knowles, Eleni Mavraki, Miriam Elbracht, Nergis Güzel, Thomas Herberhold, Ingo Kurth, Andrea Maier, Larissa Mattern, Carol J. Saunders, Helen Mccullagh, Katrin Õunap, Saskia B. Wortmann, Andre Reis, Lei Zhang, Claes M. Gustafsson, Robert Mcfarland, Robert W. Taylor

Manuscripts, Articles, Book Chapters and Other Papers

Mitochondrial diseases are a complex group of conditions exhibiting significant phenotypic and genetic heterogeneity. Genomic testing is increasingly used as the first step in the diagnostic pathway for mitochondrial diseases. We used next-generation sequencing followed by bioinformatic data analysis to identify potentially damaging variants in the POLRMT gene (NM_005035.4) in six new affected individuals. Structural protein analysis predicted the detrimental impact of variants on POLRMT protein structure. Patients show extended phenotypic abnormalities often presenting early in life with features including global developmental delay, cognitive impairment, short stature and muscular hypotonia. This study expands the genetic and phenotypic landscape of mitochondrial …

Greater Body Dissatisfaction At Admission Is Associated With Lower Bmi At Discharge In Anorexia Nervosa: Predictive Validity Of The Eating Pathology Symptoms Inventory., Danielle A N Chapa, Marianna L. Thomeczek, Brianne N. Richson, Alan Duffy, Kara A. Christensen Pacella, Kelsie T. Forbush, Renee D. Rienecke, Dan V. Blalock, Sara R. Gould, Victoria L. Perko, Philip S. Mehler

Manuscripts, Articles, Book Chapters and Other Papers

People with anorexia nervosa (AN) engage in dietary restriction and other weight loss behaviors that result in dangerously low body weight, leading to an increased risk for mortality and medical complications. Weight gain is one of the most important indicators of treatment progress and recovery for AN. There are limited predictors of weight gain for patients with AN, making it difficult for clinicians to anticipate which patients are likely to respond favorably to treatment. Thus, there is a need to identify additional, potentially modifiable predictors of weight gain within a higher level of care for AN. This study tested the …

Bovine Lactoferrin Maintains Antibacterial Effect Against Neonatal Escherichia Coli Septicaemia Isolates Despite The Presence Of Iron Acquisition Genes, Matthew Mayorga, Joshua Wheatley, Brianna N. Maldonado, Susana Chavez-Bueno

Manuscripts, Articles, Book Chapters and Other Papers

Introduction. Escherichia coli is a dominant cause of neonatal sepsis for which no prevention measures currently exist. Lactoferrin (LF) is an iron-sequestering antibacterial protein that has been noticed to decrease neonatal late-onset sepsis.Hypothesis/Gap Statement. LF's effect on in vitro growth of neonatal E. coli clinical isolates causing septicaemia is unknown. The prevalence of iron acquisition virulence genes which contribute to pathogenicity outcomes in these strains has also not been described in detail.Aim. To evaluate bovine lactoferrin's (bLF) effects on the in vitro growth of neonatal septicaemia E. coli isolates, and to determine the presence of iron acquisition virulence …

Identification Of Neural Crest And Melanoma Cancer Cell Invasion And Migration Genes Using High-Throughput Screening And Deep Attention Networks., J C Kasemeier-Kulesa, S Martina Perez, R E Baker, Paul M. Kulesa

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Cell migration and invasion are well-coordinated in development and disease but remain poorly understood. We previously showed that the neural crest (NC) cell migratory wavefront shares a 45-gene panel with other cell invasion phenomena. To rapidly and systematically identify critical genes, we performed a high-throughput siRNA screen and statistical and deep learning analyses to determine changes in NC- versus non-NC-derived human cell line behaviors.

RESULTS: We find 14 out of 45 genes significantly reduced c8161 melanoma cell migration; four of the 14 genes altered leader cell motility (BMP4, ITGB1, KCNE3, and RASGRP1). Deep learning identified marked disruptions in cell-neighbor …

Safety And Effectiveness Of Emicizumab In People With Haemophilia A Enrolled In The Athn 7 Haemophilia Natural History Study., Tyler W. Buckner, Shannon L. Carpenter, Nabil Daoud, Christine L. Kempton, Lucy Lee, Lynn Malec, Thomas W. Mclean, Paul Morton, Carrie O'Neill, Janice M. Staber, Michael Wang, Stacy E. Croteau, Michael Recht

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: The Natural History Study of the Safety, Effectiveness, and Practice of Treatment for People with Haemophilia (ATHN 7) monitors use of contemporary haemophilia therapies, including emicizumab, a bispecific antibody substituting for activated factor (F)VIII in people with haemophilia A (HA).

AIM: To report participant characteristics and real-world safety and effectiveness of emicizumab in ATHN 7.

METHODS: ATHN 7 is a prospective observational cohort study conducted across 26 American Thrombosis and Haemostasis Network (ATHN)-affiliated sites. People with HA receiving emicizumab were eligible for inclusion in this analysis. Clinical information was collected quarterly through participant interview and medical record review. Safety …

A 20th Century Historical Perspective On Congenital Syphilis And Lessons For Today., Jane F. Knapp, Robert Schremmer

Manuscripts, Articles, Book Chapters and Other Papers

No abstract provided.

Multisystem Predictors Of Dynamic Gait Stability Across Fall Risk In Older Adults, Ashwini Kulkarni, Neda Moghim, Ross Gore, Soumya Banerjee, Christopher K. Rhea, Brittany Samulski

Rehabilitation Sciences Faculty Publications

Gait stability arises from interactions between physiological, cognitive, and psychological systems, yet these domains are often assessed in isolation. This study examined multisystem predictors of anteroposterior margin of stability during walking (MoSAP) in community-dwelling older adults. Of 340 participants, 143 were retained after data quality screening (105 females; age: 70.8 ± 7.8 years). Participants completed the Physiological Profile Assessment (PPA), cognitive testing using Montreal Cognitive Assessment (MoCA), fear-of-falling evaluations using Modified Falls Efficacy Scale (MFES) and a biomechanical gait assessment during preferred and fast speeds. Participants were stratified into four PPA-based fall-risk groups: low, mild, moderate, and high risk. MoSAP …

Preoperative Patient Sentiment Is Associated With Postoperative Outcomes In Adult Spinal Deformity Surgery, Ross J. Gore, David Mazur-Hart, Mohan K. Sunkara, Aaqib Ali, Qizar Ali, Christopher J. Lynch

Center for Secure and Intelligent Critical Systems (CSICS) Publications

Study Design:

Prospective observational pilot study of adult spinal deformity surgery patients.

Objective:

To determine whether preoperative patient sentiment, quantified using a 21-class valence scale extending the CARP paradigm implemented through an offline Large Language Model, predicts postoperative outcomes.

Summary of Background Data:

Predicting adult spinal deformity surgery outcomes remains challenging with traditional clinical and radiographic parameters alone. Although patient psychological factors and expectations significantly influence postoperative satisfaction and quality of life, systematic approaches to capture these factors are underdeveloped. Offline Large Language Models offer scalable, privacy-preserving psychological risk stratification.

Materials and Methods:

We prospectively enrolled 18 patients undergoing adult …

Cognitive Prosthetic: An Ai-Enabled Multimodal System For Episodic Recall In Knowledge Work, Lawrence Obiuwevwi, Krzystof J. Rechowicz, Vikas Ashok, Sachin Shetty, Sampath Jayarathna

Computer Science Faculty Publications

Modern knowledge workplaces increasingly strain human episodic memory as individuals navigate fragmented attention, overlapping meetings, and multimodal information streams. Existing workplace tools provide partial support through note-taking or analytics but rarely integrate cognitive, physiological, and attentional context into retrievable memory representations. This paper presents the Cognitive Prosthetic Multimodal System (CPMS)—an AI-enabled proof-of-concept designed to support episodic recall in knowledge work through structured episodic capture and natural language retrieval. CPMS synchronizes speech transcripts, physiological signals, and gaze behavior into temporally aligned, JSON-based episodic records processed locally for privacy. Beyond data logging, the system includes a web-based retrieval interface that allows users …

Evaluation Of Mycoplasma Genitalium Positivity And Co-Infection With Chlamydia Trachomatis And/Or Neisseria Gonorrhoeae At Various Care Sites Across The United States, Rebecca Lillis, Rodney Arcenas, Christy M. Boraas, Steven E. Chavoustie, Lashonda Crane, Nicole D'Empaire, Aaron C. Ermel, Glenn Harnett, Federico Hinestrosa, Stacey House, Joseph Miller, Anthony Mills, Ronald Poblete, Stephen Young, Barbara Van Der Pol

School of Medicine Faculty Publications

OBJECTIVES: We evaluated Mycoplasma genitalium (MG) positivity and co-infection with Chlamydia trachomatis (CT) and/or Neisseria gonorrhoeae (NG), based on results from a trial assessing clinical performance of the Cobas® Liat CT/NG/MG point-of-care test. METHODS: A prospective, US, multicenter, noninterventional study assessed MG positivity in prospective urine samples (male) and clinician-collected vaginal swabs (female) from symptomatic/asymptomatic patients aged ≥14 years attending various clinical settings. Participants were designated positive or negative for MG, CT, and NG based on combined results from three US Food and Drug Administration-approved assays and one laboratory-developed test. MG co-infection with CT and/or NG was assessed. RESULTS: Among …

Optimizing Healthy Aging: A Preventative Approach To Support Community-Dwelling Older Adults, Jada Welke

Occupational Therapy Capstones

Introduction: Healthy aging is a complex and multidimensional process influenced by physical, cognitive, psychosocial, environmental, and lifestyle factors across the lifespan. Increasing evidence from researchers suggests that many health care systems continue to rely on reactive models that address decline only after functional limitations emerge. Preventive interventions initiated in midlife have the potential to significantly influence long-term health outcomes, independence, well-being, and quality of life. As a result, there is growing recognition that multidimensional, proactive screening and intervention should begin earlier, before age-related conditions become clinically significant.

Purpose: The purpose of this scholarly project was to address this need through …

From Play To Pressure: Understanding Early Sports Specialization Through An Occupational Lens, Kiley Jade Washnieski

Occupational Therapy Capstones

Background: Youth sport participation plays a significant role in the daily lives of children ages 6-12 (Lee et al., 2018). Participation in organized sports can offer numerous benefits; however, the expectations surrounding youth sports have evolved over time. Increased emphasis on early specialization has intensified training demands and performance pressures placed on youth athletes during critical developmental years (Brenner et al., 2019). Although occupational therapy is well positioned to address both the physical and psychosocial demands of youth sport participation, the profession’s role within this context remains underexplored (Bulan et al., 2025).

Purpose: The purpose of this scholarly project was …

Family-Centered Programming For A Rural Midwest Emergency Shelter: An Occupational Lens, Ariel Kathryn Tix

Occupational Therapy Capstones

Introduction: After a period of decline in homelessness, a startling trend reversal occurred between 2023 and 2024; there was a 39% increase in families experiencing homelessness in the United States (de Sousa & Henry, 2024). Rural homelessness is less visible and often looks different from urban homelessness, which presents challenges that require a different approach (Brott et al., 2019). Individuals experiencing homelessness have challenges in every area of occupation and could benefit from novel strategies and resources. Challenges include parenting, accessing medical care, obtaining permanent housing, community mobility, and meaningful routine development (American Occupational Therapy Association, 2020; Brott et al., …

Expanding Access To Hand Therapy In Rural Wyoming Through Telehealth, Cheyenne Rose Thompson

Occupational Therapy Capstones

Individuals living in rural Wyoming experience significant barriers to accessing specialized hand therapy services, including geographic isolation, limited availability of certified hand therapists, and inconsistent healthcare infrastructure, resulting in delayed rehabilitation and reduced functional outcomes (Hirth et al., 2022; Rural Health Information Hub, 2025). Although telehealth has emerged as a potential solution to improve access, challenges related to clinician training, safety, and adaptation of interventions to virtual environments persist (Feldhacker et al., 2022; Morris, 2024). The purpose of this scholarly project was to develop an evidence-based telehealth hand therapy program to improve access to upper extremity rehabilitation services in rural …

The Lens Of Farmers: Understanding Culture To Improve Occupational Therapy Care, Allison Marie Stephani

Occupational Therapy Capstones

Introduction: Accessible healthcare is essential for farmers due to their limited available time and hazardous job duties (Hildebrand et al., 2019; Hopkins et al., 2023; Salmon et al., 2025; U.S. Department of Agriculture, 2023). Due to the high incidence of injuries that occur within the profession, it is crucial that farmers seek appropriate healthcare services to address these concerns. However, a significant barrier for seeking healthcare assistance is the limited cultural competence among healthcare professionals in understanding the unique needs within farming communities (Gordon et al., 2024; Hildebrand et al., 2019; Hopkins et al., 2023; Purc-Stephenson et al., 2024). The …

Occupational Therapy In Rural North Dakota Schools To Enhance Transition Planning, Kyra M. Schwartz

Occupational Therapy Capstones

Background: Access to services does not guarantee participation. Youth with disabilities, particularly in rural communities, continue to experience disparities in postsecondary outcomes related to employment, education, and independent living. While transition services are available, barriers related to awareness, coordination, and usability limit effective engagement. These challenges highlight a gap between service availability and access within rural systems and contribute to reduced participation outcomes.

Purpose: The purpose of this scholarly project was to develop an occupational therapy– informed, advocacy-driven approach to improve access to and navigation of transition services for youth with disabilities in rural communities.

Methodology: A multi-method, iterative approach …

Swimming With Confidence From An Occupational Therapy Perspective, Emma M. Schultz

Occupational Therapy Capstones

Background: Autism Spectrum Disorder (ASD) is a neurological disorder that impacts thousands of people and their families. Those with an ASD diagnosis demonstrate difficulty with safety awareness are at an increased risk to die due to drowning. Those with autism are often drawn to water for a multitude of reasons especially after an elopement attempt. There has been an increased awareness and development in aquatic therapy to reduce the drowning risks for those with ASD. Occupational therapists have begun to develop interventions that targets basic swimming and water safety. During these interventions, occupational therapists use their skills of activity analysis, …

The Effect Of Sensory Processing And Integration On Engagement In Occupations For Children With Sensory Processing Disorders, Ashley Schindele

Occupational Therapy Capstones

Background: Sensory Processing Disorder (SPD) is a condition where the person is unable to process and respond to sensory information (Guardado & Sergeant, 2023). Children who are lacking sensory integration skills may have more behavior problems due to their inability to regulate their responses (Guardado & Sergeant, 2023; Pfeiffer et al., 2013). Children with SPD may have abnormal sensitivities in any or all the sensory systems which may cause the child to not participate in their occupations (Guardado & Sergeant, 2023; Parham & Mailloux, 2020).

Purpose: The purpose of this scholarly project was to provide parents/caregivers a handout that thoroughly …

Harvesting Health: Cultivating Skills For Wellness In Agricultural Workers, Katie Renee Quinley

Occupational Therapy Capstones

Purpose: The nature of agricultural work is physically demanding and associated with an increased risk of musculoskeletal injury due to repetitive movements, heavy lifting, awkward postures, and prolonged physical labor. Despite the importance of agriculture as a meaningful occupation and major contributor to the workforce, limited resources address the unique physical demands of agricultural labor. The purpose of this scholarly project was to develop a video-based educational resource to promote safety and continued occupational participation in agricultural workers. Additionally, the project aims to assist therapy professionals in implementing ergonomic and task modifications through an accompanying resource guide.

Methodology: A literature …

Enhancing Leisure Opportunities For People With Disabilities In Rural Communities, Joslyn Mary Nordmark

Occupational Therapy Capstones

Purpose. The purpose of this scholarly project was to promote access to leisure opportunities for people with disabilities in rural areas. The author addressed unmet needs among this population considering personal, occupational, environmental, cultural, and socioeconomic factors. The goal was to develop a product that provided opportunities regardless of abilities to promote leisure exploration and participation, social engagement, and life skill development for people with disabilities

Methods. The author conducted a needs assessment through a literature review following the Model of Human Occupation (MOHO), collaborations with site staff, and an on-site observation and environmental analysis. Data was examined to identify …

The Missing Link: Psychosocial Integration In Neuro Ot Care, Emily Nelson

Occupational Therapy Capstones

Introduction: Over 1 in 3 people are affected by neurological conditions, making it the leading cause of illness and disability worldwide (World Health Organization, 2024). Patients are often referred to inpatient rehabilitation to increase independence and functional recovery. There is a need to address psychosocial factors within this setting thus, The Missing Link: Integrating Psychosocial Factors into Neuro OT was created.

Methodology : The capstone is guided by the Model of Human Occupation (MOHO), which emphasizes the dynamic interaction between the person and their environment and its influence on psychosocial factors, personal identity, and competence. A comprehensive needs review was …

Cultivating Connections: Empowering Agricultural Community Members Through Collaborative Care, Kearyn E. Nelsen

Occupational Therapy Capstones

Background: Agriculture and mental health – two words not typically used in the same sentence; however, considering the rate of suicide among those working in the agriculture profession is significantly higher than the general population, the need for both awareness and action is critically important. Despite a lack of research specific to occupational therapy and the agricultural population, occupational therapists on an interprofessional healthcare team are uniquely positioned to serve this population. Interprofessional collaboration is essential when serving agricultural community members, whose needs involve a complexity of physical, mental, social, and environmental factors, each impacting the overall health and well-being …