Digital Commons Network^™

Yk-4-250, A Synthetic Telmisartan-Tempol Conjugate: Crystal Structure Of A Stabilized Free Radical Containing An Angiotensin At₁ Receptor Inhibitor, Simon Friedrich, Yali Kong, Faik N. Musayev, Milton L. Brown, B. Frank Gupton

Department of Biomedical and Translational Sciences Faculty Publications

We report the first crystal structure of the telmisartan-tempol conjugate 2,2,6,6-tetramethyl-1-(λ'-oxidaneyl)piperidin-4-yl 4'-[(1,7'-dimethyl-2'-propyl-1H,3'H-[2,5'-bibenzo[d]imidazol]-3'-yl)methyl]-[1,1'-biphenyl]-2-carboxylate free radical (YK-4-250, C₄₂H₄₆N₅O₃), a dual-function inhibitor designed to target both the angiotensin II type 1 receptor (AT₁R) and reactive oxygen species (ROS). Structural analysis reveals a unique crystal architecture in which the nitroxide radical is stabilized within a sterically protected environment while preserving the telmisartan pharmacophore essential for high-affinity receptor antagonism. YK-4-250 is a novel small-molecule conjugate of telmisartan and tempol that incorporates a catalytic stabilized nitroxide radical and was rationally designed to mitigate gastrointestinal acute radiation syndrome (GI-ARS).

Teachers' Perspectives On Inclusive Education For Children With Special Needs, Abakah Francis, Ava-Gay Annakaye Morgan, Emmanuel Ogheneovo Sodje, Francis Dugbartey, Gabriel Lagbel, Okezie Chika Chibundu

Educational Leadership & Workforce Development Faculty Publications

Inclusive education is widely recognized as a key approach to ensuring equitable access to quality education for children with special needs, requiring teachers to possess adequate knowledge, skills, and supportive resources. In the Nigerian context, particularly in private schools, gaps in teacher training, limited resources, and insufficient institutional support continue to hinder the effective implementation of inclusive education practices. This study investigates teachers' perspectives on inclusive education for children with special needs in Nigerian private schools. The primary purpose is to assess teachers' understanding of inclusive education, their familiarity with effective teaching strategies, and their preparedness to implement inclusive practices. …

The Presidential Address To The Association For Career And Technical Education Research: Cte Research Ecosystem Growing Scholars And Workforce Capacity, Michelle E. Bartlett

Educational Leadership & Workforce Development Faculty Publications

Career and Technical Education (CTE) research has advanced knowledge, strengthened communities, informed policy, and expanded pathways to opportunity for decades. As ACTER begins a new chapter, we are invited to imagine the future of our field beyond a linear pipeline. We can embrace a view of CTE research as a living ecosystem that grows talent, supports collaboration, and sustains discovery over time. This presidential address emphasizes three priorities for that future: applied research that reaches practice, mentorship that nurtures the next generation of scholars, and partnerships that ensure knowledge becomes action. By centering learners and communities in our work, we …

Clinical Correlates Of Insomnia Symptoms In Young Children With Autism Spectrum Disorder, Megan L. Wenzell, Stephanie Griggs, Camdyn Roark, Megha Patil, Manav Patel

Faculty Scholarship

Objective: To examine clinical correlates of insomnia symptoms in children with autism spectrum disorder ascertained from a general outpatient autism clinic. Study design: This analysis included 103 children with autism spectrum disorder (mean age = 5.8 ± 2.2 years; range 2-10, 77.7% male). A multidisciplinary team assessed medical and psychosocial histories using parent ratings from the Pediatric Autism Insomnia Rating Scale (PAIRS), Aberrant Behavior Checklist (ABC), Brief Autism Mealtime Behavior Inventory, and the Parent Health-Related Quality of Life and Family Functioning and Family Functioning Surveys. Height and weight were collected. Children in the current sample with scores on the PAIRS …

The Impact Of Brand Awareness On Customer Perceptions And Purchasing Decisions At Small Chinese Takeaway Restaurants In Ireland, Jiajia Wang

Business ETD Collections

This study examines how brand awareness influences customer perception and purchasing decisions, and explores the branding challenges faced by small Chinese takeaway businesses in Ireland. A mixed-methods approach was used, combining 57 customer questionnaires with three semi-structured interviews with takeaway business owners.

The findings show that brand awareness influences customer purchasing behavior, as customers are more likely to choose familiar takeaway brands. However, its impact on customer perception, particularly perceived value and willingness to pay, is limited. Customers place greater importance on practical factors such as price, food quality, and service.

The study also identifies key branding challenges for small …

The Role Of Leadership Communication In Shaping Employee Engagement: A Case Study Of Supervalu Talbot Street, Dublin, Elizabeth Montserrat Ibarra Arteaga

Business ETD Collections

Employee engagement is one of the key determinants of organisational performance, especially in labour-intensive industries, such as grocery retail. This paper will focus on how leadership communication contributes to the creation of employee engagement in SuperValu Talbot Street, Dublin. The study uses the Job Demands-Resources (JD-R) model and social exchange theory to examine the roles of communication practices and their use as a significant resource in employee motivation and workplace experience. The qualitative case study approach was embraced where semi-structured interviews were carried out with four managers and seven frontline employees. The results indicate that the clarity of communication, feedback …

Trust And Social Licence Challenges In Oyu Tolgoi’S Engagement With Local Communities In Mongolia, Anudari Enkhbayar

Business ETD Collections

This dissertation explores trust and stakeholder engagement in the case of the Oyu Tolgoi Mine in Mongolia. It focuses on the relationship between the mine and local communities, especially in terms of trust, fairness and long-term social licence to operate. While mining can support economic growth, jobs and investment, it can also create environmental concerns, social tension and conflict when local communities feel ignored or unfairly treated.

The study asks two main questions: what factors have contributed to trust challenges between Oyu Tolgoi and local communities, and how stakeholder engagement can help strengthen long-term social licence to operate.  The research …

Counselors' Lived Experiences Of Moral Injury: A Social Ecological Perspective, Lisa M. Belknap

Antioch University Dissertations & Theses

This study explores the lived experiences of counselors who encountered moral injury when sociopolitical, institutional, and organizational conditions constrained their ability to practice in alignment with their personal morals, professional values, and the counseling profession’s code of ethics. Participants (N = 15) included licensed counselors who self-identified as having experienced moral injury in response to directives from legitimate authorities that conflicted with professional ethics, social justice commitments, or client welfare. Grounded in social ecological systems theory, this phenomenological study employed a confidential, cross-sectional online survey. Reflexive thematic analysis identified seven themes: (a) Profit Over People, (b) Structural Forces Contributing to …

The Lived Experience Of Tenders Of Community Grief Rituals, Margaret Y. Wilson

Antioch University Dissertations & Theses

The purpose of this research study is to gain an understanding of the lived experience of tenders of community grief rituals, and how tenders make meaning of their experiences. This study utilized photo elicitation and a reflexive thematic analysis. Participants (N = 11) provided one to three photographs that captured their experience of grief and/or tending grief rituals. The results identified 10 themes supported by subthemes: (a) Grief Tender Wisdom About the Nature of Grief, (b) Life’s Many Experiences are Sources of Grief, (c) The Multifaceted Impacts of Grief-Body, Anger, Compassion, Empathy, Resilience, Gratitude, Joy, and Love, (d) The Nuances …

Beyond The Diagnosis: A Qualitative Exploration Of Men Living With Hiv, David R. Romanelli

Antioch University Dissertations & Theses

This qualitative study explored the lived experiences of men (18+ years old) living with HIV to better understand how they navigate identity, mental health, relationships, and healthcare systems after diagnosis. The method included a qualitative thematic analysis with 10 participants. Eight themes emerged from the data: (1) reactions, reflections, and meaning-making after diagnosis; (2) managing medication, treatment, and co-occurring conditions; (3) stigma, disclosure, and negotiation of identity; (4) substance use, housing instability, and socioeconomic stressors; (5) navigating the changing HIV landscape; (6) experiences with family and intimate relationships; (7) implications for mental health counseling; and (8) the role of community …

The Use Of Mindfulness In Empirically Supported Treatments In Psychology, Timothy Stewart

Antioch University Dissertations & Theses

After gaining popularity in the United States of America (USA) in the 1960s and 1970s, Buddhist mindfulness was introduced to clinical psychology and investigated for its potential psychological healing effects. In the years since, mindfulness has been widely used in empirically supported treatments (ESTs) in clinical psychology in the USA to treat a wide variety of psychological conditions and disorders. This dissertation examines and compares conceptualizations and implicit understandings of mindfulness in early (Theravāda) Buddhism and in ESTs in clinical psychology in the USA. Through textual narrative analysis of two Buddhist sutta and 10 clinical psychology journal articles, this study …

Leading With Heart: The Impact Of Emotional Intelligence On School Principal Performance, Gregory Lucas

Antioch University Dissertations & Theses

The role of school principals has evolved significantly in recent years, particularly in response to the challenges posed by the COVID-19 pandemic. Declining student mental health, chronic absenteeism, and heightened levels of anxiety and depression among teachers have underscored the need for school leaders to adopt a more holistic approach to leadership. Principals are now expected to address not only academic and administrative responsibilities but also the social and emotional well-being of their school communities. Emotional intelligence (EQ) has emerged as a critical competency for effective leadership, enabling principals to navigate complex interpersonal dynamics, foster positive school climates, and support …

The Effect Of Paternal Engagement On The Sexual Self-Concept Of Black Female Adolescents, Amelia Flynn

Antioch University Dissertations & Theses

Black women in the U.S. continue to experience disproportionately high rates of unintended pregnancies, with a 64% rate reported in 2011 (Finer & Zolna, 2016). Positive sexual self-concept (SSC) is linked to healthier sexual behaviors, yet research on SSC development has largely overlooked the role of fathers and systemic influences, particularly within Black families. Grounded in an ecological framework, this study examines the impact of father-daughter engagement on SSC among Black female adolescents, considering paternal residential status and socioeconomic class as key contextual factors. The study revealed that when middle class father-daughter engagement is high, daughters’ sexual self-esteem is lower. …

Remembering Right Relations: A Land-Centered Framework For Settler Teacher Transformation, Aimee E. De Ney

Antioch University Dissertations & Theses

Settler colonialism is based in the separation of peoples from Lands and from one another, producing ongoing harm to human and more-than-human communities as evidenced in climate collapse, racialized violence, war, and widening social inequities. These conditions are sustained by ideologies of human supremacy-specifically white, male, Christian human supremacy-that deny personhood to most humans and to all more-than-humans, while enabling the attempted erasure of Indigenous peoples and the nation-state enforcement of anti-Black and anti-Brown racism. Situated on the Lands of the Coast Salish Peoples in the Pacific Northwest of the United States, this multiparadigmatic innovation dissertation develops a Land-centered framework …

Virtual Communities, Real Identities: Bi+ Storying And Connection On Youtube, Gabrielle Gershoni

Antioch University Dissertations & Theses

This dissertation explored how bi+ individuals narrate identity, belonging, and community connection through personal storytelling on YouTube. Despite being a significant subset of the LGBTQIA+ population, bi+ individuals face unique challenges such as monosexism, bi-erasure, and binegativity. These systemic challenges contribute to health disparities and a pervasive lack of belongingness in both straight and queer communities. Using a narrative inquiry framework and reflexive thematic analysis, this study examined six publicly shared narratives of bi+ YouTube creators to investigate how digital spaces are utilized to construct and discus bi+ identities. Heteronormative socialization, “clicks” of identity recognition, relational negotiations, and misrecognition both …

Netflix And Feel: Cultivating Fandom And Identity Through Sports Docuseries, Jessica L. Payne

Faculty Publications - Communications

This work investigated how parasocial relationships (PSRs), audience behaviors, and sports docuseries consumption jointly shape today’s sports fandom. The research utilized a combination of social identity theory (SIT) with PSR, conducting a survey of 277 participants to test a moderated mediation model (Hayes PROCESS Model 7). This model examined the relationships between PSRs, docuseries consumption, fandom, and behavioral engagement outcomes such as intent to recommend, cross-platform engagement, multi-platform viewing habits and brand engagement, live engagement and event intentions, intent to continue viewing, and fan conversion. This research contributed to SIT by demonstrating how streaming platforms and docuseries offer a different …

A Quantitative Analysis Of Barriers To College Students’ Seasonal Vaccination Intentions And Behaviors, Kelly S. Clemens, John Matkovic

Faculty Publications – Health Sciences

Objective
Vaccination is crucial to college student health, but quantitative analyses of barriers in this population are limited. The present study expands the work of Su and Chen to determine the relative influence of structural, psychological, and social vaccination barriers.

Participants
Participants were 650 students from a large, midwestern university during the 2024 vaccination season.

Methods
Participants were recruited from a college campus and randomized to respond to items assessing their barriers to, intentions to receive, and uptake of the COVID-19 or influenza vaccination.

Results
Structural, psychological, and social barriers were differentially important to vaccinations and to intentions vs. uptake …

A Systems Analysis Of Long-Term Community Recovery Following The 2023 Lāhainā Wildfire: Understanding Recovery As A Complex Adaptive Social-Ecological System, Christy Shaver

Antioch University Dissertations & Theses

No abstract provided.

Mental Health Therapists’ Experiences Of Moral Injury, Mary Krome

Antioch University Dissertations & Theses

Moral injury refers to the psychological, social, behavioral, and spiritual consequences that may result from experiences involving perceived violations of deeply held moral values and beliefs. Although research on moral injury has expanded beyond military populations, limited attention has been given to the experiences of mental health therapists, and qualitative investigations of this phenomenon remain scarce. Therefore, this project provides a qualitative assessment of mental health therapists’ lived experiences of moral injury, using an ecosystemic approach and accounting for biopsychosocial factors that influence experiences of moral injury. Six mental health therapists completed the Moral Injury and Distress Scale and endorsed …

A Qualitative Analysis Of Fitness Wearable Use And Embodiment, Lucas Brandt

Antioch University Dissertations & Theses

Wearable fitness technologies have become increasingly integrated into contemporary health and wellness culture, providing users with continuous access to physiological and behavioral data related to movement, sleep, stress, recovery, and overall health. Research has demonstrated that wearable devices can increase physical activity and support health behavior change (Ferguson et al., 2022; Koivisto & Hamari, 2019). Although less is known about how these technologies influence individuals’ lived experiences of their bodies. Understanding this relationship is particularly important given growing concerns regarding embodiment, self-surveillance, and the psychological effects of health-tracking technologies (Bergsland, 2017; Rapp, 2021). Drawing on theories of mind-body connection and …

Doctoral Trainees’ Experiences Of Vicarious Trauma Within Inpatient Settings: An Exploratory Study, Melissa Neitlich

Antioch University Dissertations & Theses

Vicarious trauma (VT), first coined by Irene Lisa McCann and Anne Pearlman, is described as a pervasive and cumulative impact of working with survivors of trauma, resulting in changes to the therapist’s identity, worldview, psychological needs, beliefs, and memory. In spite of the unique vulnerabilities of doctoral trainees for experiencing VT, there is limited research on the impact of VT among doctoral trainee populations, as most of the extant literature focuses on the impact of VT in middle- to late-career psychological practice. In this primarily qualitative dissertation, I examined trainees’ experiences of vicarious trauma within various inpatient settings using the …

Impact Of Therapeutically Applied Role-Playing Games (Ta-Rpg) For Individuals At The Intersection Of Sexual And Gender Minorities (Sgm) And Autism Spectrum Disorder (Asd), Alexander S. Gelernter

Antioch University Dissertations & Theses

Individuals with Autism Spectrum Disorder (ASD) who also identify as sexual and gender minorities (SGM) may experience intersecting challenges related to communication, social belonging, masking, identity development, and access to affirming clinical spaces. Although role-play and therapeutically applied role-playing games (TA-RPGs) have been described as promising experiential approaches, limited research has examined how ASD/SGM individuals themselves understand role-playing games (RPGs) or evaluate their possible therapeutic use. This qualitative study explored how young adults with ASD level 1 who identify as SGM describe their experiences with RPGs and how they appraise the potential usefulness, risks, and conditions of TA-RPG. Five participants …

Climate Resilience In Action: Process-Based Equity For Co-Governed, Socially Cohesive, Ecologically Integrated Democracies Through The Design And Implementation Of Nature-Based Solutions, Donna Choih

Antioch University Dissertations & Theses

Nature-based Solutions (NbS) governance and behavior have the potential to become more equitable, beginning with a closer examination of what equity entails. Governance and behavior together are the actions manifest from internal dispositions and thoughts that facilitate the process of decision-making, in this case, for equitable NbS. This critical review seeks to (1) address the gap in literature on human development and behavioral dimensions of procedural justice for NbS by further defining process-based equity (PbE), and (2) present a framework of best practices for equitable NbS. This framework, along with a complementary conceptual model, was developed using the Preferred Reporting …

The Psychological Process Of Decolonizing The Colonized Self: A Grounded Theory Based On Hong Kongers’ Decisions After The 2019 Protests, Lai Kwan Shirley Lo

Antioch University Dissertations & Theses

Hong Kong, a British colony for over a century, was returned to China in 1997. In 2019, the proposal of an extradition bill sparked widespread outrage, leading to a year of unprecedented social unrest. The protests eventually dissipated with the advent of the COVID-19 pandemic and the Chinese central government’s tightening controls. Although the state characterized its interventions as decolonization, a significant wave of Hong Kongers responded by leaving their homeland to cultivate new lives in the “Western world,” including Britain. How does a colonized population willingly return to their colonizer after decolonization? This study sets out to search for …

Ai Tips And Traps, Patrick Barry

Books

Based on a series of popular courses and workshops that Professor Patrick Barry has created for students, professionals, and anyone else interested in taking a skills-based approach to artificial intelligence, this book gives you a chance to engage with important AI concepts, experiment with exploratory AI exercises, and then ultimately develop your own customized list of AI traps to try as well as AI traps to avoid.

Cumulative Burdens On Second Amendment Rights, Joseph Blocher, Hayley Lawrence

Faculty Scholarship

No abstract provided.

Synergistic Removal Of Microplastic Fibres: Integrating Chitosan Coagulation In Hybrid Water Pre-Treatment Systems, Jayasuriya Arachchilage Nimesha Thathsarani

Theses: Doctorates and Masters

Microplastic fibres (MPFs) are the most prevalent form of microplastics detected in the influents of water and wastewater treatment plants. Owing to their elongated shape and low density, MPFs frequently evade removal even during tertiary processes such as membrane filtration. Enhancing pretreatment, particularly through cost-effective coagulation-flocculation can reduce the treatment burden on downstream systems. However, conventional inorganic coagulants often necessitate high dosages and can leave residual ions, posing environmental concerns.

As a sustainable alternative, the use of environmentally friendly coagulants such as Chitosan has gained attention for MPF removal. While Chitosan exhibits favourable qualities, its practical application is hindered by …

The Development Of A Midwifery Specific Tool To Identify The Barriers And Enablers To Change Within The Midwifery Setting, Sara Davis

Theses: Doctorates and Masters

Despite being well-positioned to identify service gaps and propose improvements, many midwives lack the knowledge, skills, confidence, or tools to effect practice change. Implementation science (IS) offers a structured approach to moving evidence-based innovations into practice; however, existing IS theories, models, and frameworks do not reflect the unique context of midwifery practice. The first step in the intentional implementation of an evidence-based practice innovation is to conduct a context assessment to identify factors that may facilitate or impede its uptake. There are numerous evidence-based checklists for this, but none capture all the influences on midwifery practice environments.

In this study, …

The Development And Pilot Evaluation Of An Out-Of-Hospital Immersive Birthing Simulation Training Application For Paramedics And Ambulance Officers Using Virtual-Reality Technology, Michella Hill

Theses: Doctorates and Masters

Out-of-hospital births (OOHBs) are births which occur outside a hospital setting. This includes planned home births attended by midwives, or unplanned OOHBs where the intention was to birth in a hospital or maternity centre, however, occurs in an unintended location. Prehospital clinicians, inclusive of registered paramedics and volunteer ambulance officers (VAOs) infrequently attend OOHBs, as most births occur in maternity wards as anticipated. OOHBs comprises < 1% of emergency ambulance requests and requires specialised skills for prehospital clinicians to competently manage birthing and potential complications. As exposure to birthing is so rare, these specialised skills and knowledge are underutilised and subject to rapid decay. Compounding the problem, obstetrics is infrequently taught across undergraduate education, in-service training, or within individual clinician’s continuing professional development. Placements shadowing midwives are scarce due to nursing and medical students receiving priority. Previous research regarding OOHBs is limited, nonetheless suggests prehospital clinicians are underprepared to manage an OOHB, which has serious patient safety implications. The present research sought to explore prehospital clinicians’ preparedness and confidence in managing OOHBs. It also investigates whether a digital training solution such as virtual reality (VR) simulation may reduce the theory-practice gap and assist in competency retention.

Publication one provides a comprehensive methodology outline which is applied to Study One; a scoping review of prehospital clinician and birth parent experiences with OOHBs. Risk factors, complications and interventions provided by prehospital clinicians, as …

Ornithine Metabolism In Retinal Pigment Epithelium And Retina And Implications In Gyrate Atrophy, Artjola Puja

Graduate Theses, Dissertations, and Problem Reports (ETD)

Ornithine aminotransferase (OAT) is a mitochondrial enzyme that regulates ornithine metabolism by converting ornithine to pyrroline-5-carboxylate, a precursor for proline and glutamate synthesis. Deficiency of OAT causes systemic ornithine accumulation and leads to gyrate atrophy (GA) of the choroid and retina, a hereditary disorder characterized by progressive chorioretinal degeneration and irreversible vision loss. Chorioretinal atrophy typically starts at the mid-peripheral retina and progresses toward the macula. Although elevated ornithine is considered toxic to the eye, how ornithine is metabolized in ocular tissues and why OAT deficiency causes selective, region-specific vulnerability remain unclear. We combined ex vivo and in vivo stable …