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Articles 48211 - 48240 of 1791773
Full-Text Articles in Entire DC Network
Supplemental Files For "From Knowledge To Practice: Deia Perspectives, Faith-Based Policies, And Job Postings", Sarah E. Keil, Meredith Ader, Gina K. Bolger, Ryan Yoakum
Supplemental Files For "From Knowledge To Practice: Deia Perspectives, Faith-Based Policies, And Job Postings", Sarah E. Keil, Meredith Ader, Gina K. Bolger, Ryan Yoakum
University Faculty Publications and Creative Works
Supplemental files for the book chapter, "From Knowledge to Practice: DEIA Perspectives, Faith-Based Policies, and Job Postings." Tge job posting spreadsheet and reference list are available below.
Job Posting Spreadsheet
The PDF of the Job Posting Spreadsheet includes the following items:
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A comprehensive spreadsheet of the job ads used in this project, with additional information about the institution included (DEIA statement, affiliations, accreditation, etc.)
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A spreadsheet with other information about the institutions, including links to statements of faith, missional documents, etc.
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A spreadsheet with information about how DEIA is defined by various organizations and accrediting bodies
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Color coding key
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An …
Health Truth To Power: Professional Collaboration To Bolster Trust Against Misinformation, William M. Sage, Keegan D. Warren
Health Truth To Power: Professional Collaboration To Bolster Trust Against Misinformation, William M. Sage, Keegan D. Warren
Faculty Scholarship
This Article is about health, leaving aside more general challenges to shared civic information today. The Article begins by surveying the principal challenges for health information in post-pandemic, arguably post-truth America, and then describes briefly the sources and limits of medical professional authority. Noting the double-edged sword of free speech guarantees under the U.S. Constitution, the Article continues by commenting on speaking truth to government, to industry, and to the crowd. Next, the Article considers the physicians’ role in speaking truth to power from the perspective of standard medical professional ethics and identity, comparing it to that of lawyers. Finally, …
Assessing The Robustness Of Prithvi Geospatial Foundation Model For Coastal Habitat Mapping Under Data Availability And Domain Shift Scenarios, Sam Khallaghi, Rishi Singh, Rahebeh Abedi, Ronald J. Eastman, Lyndon Estes, Sujit Roy, Rahul Ramachandran, Hamed Alemohammad
Assessing The Robustness Of Prithvi Geospatial Foundation Model For Coastal Habitat Mapping Under Data Availability And Domain Shift Scenarios, Sam Khallaghi, Rishi Singh, Rahebeh Abedi, Ronald J. Eastman, Lyndon Estes, Sujit Roy, Rahul Ramachandran, Hamed Alemohammad
Geography
Self-supervised learning techniques and geospatial foundation models are garnering increasing attention within the remote sensing community, marking a pivotal shift toward more adaptable, generalizable and data efficient methodologies. Despite their growing popularity, comparative analyses between these emergent models and traditional, task-specific supervised deep learning models for tasks such as semantic segmentation remain largely unexplored. This study is formulated as a comparative analysis to scrutinize the efficacy of the finetuned Prithvi geospatial foundation models against a supervised convolutional neural network trained from scratch for semantic segmentation of mangrove forests and pond aquaculture under varying levels of data availability and domain shift. …
Understanding The Syphilis Resurgence Among Females Of Childbearing Age: Informing Prevention Efforts In New York State, Salvatore Currenti
Understanding The Syphilis Resurgence Among Females Of Childbearing Age: Informing Prevention Efforts In New York State, Salvatore Currenti
Electronic Theses & Dissertations (2024 - present)
Syphilis is caused by Treponema pallidum and transmitted through direct contact with infected mucosal lesions and via vertical transmission during pregnancy (i.e., congenital). Transmission of syphilis to an infant during pregnancy (i.e., congenital syphilis [CS]) can lead to early fetal death, stillbirth, neonatal death, preterm birth, low birthweight, and congenital infection in infants. The United States (U.S.) is experiencing epidemic increases in both females of reproductive age with syphilis and infants with CS. In New York State (NYS), these trends have also occurred, especially after COVID-19 emergence, and increases in reported cases and incidence rates are comparable to national statistics. …
Disentangling Exercise Motivation From Eating Disorder Symptom Severity: A Dominance Analysis Of Compulsive Exercise Predictors, Sarah E. Siegel
Disentangling Exercise Motivation From Eating Disorder Symptom Severity: A Dominance Analysis Of Compulsive Exercise Predictors, Sarah E. Siegel
Electronic Theses & Dissertations (2024 - present)
Compulsive exercise (CE) appears frequently in eating disorder (ED) samples but also occurs in nonclinical populations, raising the possibility that different motivational processes drive the behavior, perhaps depending on ED pathology. This study examined the relative contribution of exercise motives to CE while separating motivational variance from ED symptom severity. Undergraduate women (N = 376; 38.3% White, 28.8% Black) completed the Exercise Motivations Inventory–2 (EMI-2), the Compulsive Exercise Test (CET), and the 7-item Eating Disorder Examination Questionnaire (EDE-Q7). An exploratory factor analysis of EMI-2 subscales yielded four factors: Affective Well-being (Enjoyment, Revitalization, Stress Management), Health/Function (Ill-health Avoidance, Nimbleness, Positive Health, …
Relational Efficacy Beliefs In Supervision Of Master’S Level Counseling Trainees As Predictors Of Counseling Interests And Goals, Taylor Karnilaw
Relational Efficacy Beliefs In Supervision Of Master’S Level Counseling Trainees As Predictors Of Counseling Interests And Goals, Taylor Karnilaw
Electronic Theses & Dissertations (2024 - present)
Master's level counseling trainees have condensed training periods before making career-related decisions and are often placed in settings with high rates of burnout and turnover. Supervision has been shown to be a protective factor for burnout and has the potential to be a source of self-efficacy, which has been linked with career-related outcomes like occupational interests and goals (Lent et al., 2018; O’Connor et al., 2018). Moreover, within the context of close relationships, like supervision, efficacy beliefs are believed to be shaped by a network of beliefs, including relation-inferred self-efficacy, self-efficacy, and other-efficacy (Lent & Lopez, 2002). The current study …
School-Based Interventions With Youth Engaging In Bullying Behaviors: Effective Strategies From The Perspective Of School Social Workers, Elizabeth A. Crowe
School-Based Interventions With Youth Engaging In Bullying Behaviors: Effective Strategies From The Perspective Of School Social Workers, Elizabeth A. Crowe
Electronic Theses & Dissertations (2024 - present)
Bullying is a nationally recognized social problem associated with harmful consequences for all youth involved. Despite their crucial role in bullying interventions and student success, the practices and perspectives of school social workers are notably absent from academic literature. This survey research study sought to identify strategies that school social workers use with youth engaging in bullying behavior; distinguish which strategies are the most and least effective from the perspective of school social workers; and recognize the supports and barriers school social workers face when implementing bullying interventions.
Survey data from a sample of school social workers answered these questions. …
The Moderating Effect Of Self-Efficacy On The Relationship Between Social Determinants Of Health And Alcohol Use In A Diverse Adult Sample, Cara L. Fresquez
The Moderating Effect Of Self-Efficacy On The Relationship Between Social Determinants Of Health And Alcohol Use In A Diverse Adult Sample, Cara L. Fresquez
Electronic Theses & Dissertations (2024 - present)
Heavy alcohol consumption is associated with a range of psychosocial problems and chronic conditions, resulting in approximately 140,000 preventable deaths each year. With these potential consequences in mind, it is understandable that 46% of individuals who consume alcohol report attempting to reduce the quantity of alcohol they drink; however, very few enter formal treatment. Despite this, many people will decrease their heavy drinking over time, presumably due to individual and environmental factors, particularly self-efficacy and protective social determinants of health (SDoH). This study aimed to answer the research question “How is SDoH adversity related to the likelihood of reporting reduced …
The Maxima Method For Identification Of Principal Periodic Components In Time Series Analysis, Megan Di Maio
The Maxima Method For Identification Of Principal Periodic Components In Time Series Analysis, Megan Di Maio
Electronic Theses & Dissertations (2024 - present)
This dissertation investigates methods for mean estimation in periodically correlated time series, focusing on the Variable Bandpass Periodic Block Bootstrap (VBPBB) and a novel data-driven maxima method. Time series require specific methods because of the temporal correlation in the data. Traditional methods like the General Seasonal Block Bootstrap (GSBB) account for this correlation but often produce wide confidence intervals because they cannot isolate multiple periodicities, allowing noise and other frequencies to interfere with analysis. The VBPBB method addresses this by applying a Kolmogorov-Zurbenko Fourier Transform (KZFT) filter to the data before bootstrapping, which suppresses interfering frequencies and results in narrower, …
Ready. Set. Prevent: Turning Risks Into Results, Demi Goolsby, Keyuanna Mcgee, Jeannie Ricks, Jimesha Walker, Manuel Zuniga
Ready. Set. Prevent: Turning Risks Into Results, Demi Goolsby, Keyuanna Mcgee, Jeannie Ricks, Jimesha Walker, Manuel Zuniga
MSN Research Projects
Hypertension remains a leading modifiable risk factor for cardiovascular disease and contributes significantly to morbidity and mortality in Mississippi. Despite the availability of evidence-based clinical treatment guidelines, rates of uncontrolled and undiagnosed hypertension remain disproportionately high. The purpose of this study is to examine the extent to which nurse practitioners in Mississippi are aware of and incorporate the updated 2025 American Heart Association (AHA) hypertension guidelines and the PREVENT cardiovascular risk stratification tool into clinical practice. A non-experimental, descriptive, quantitative design using survey methodology with convenience sampling was employed. Online scripting via social media platforms was utilized to recruit licensed …
Purpose-Driven Compliance, Veronica Root Martinez
Purpose-Driven Compliance, Veronica Root Martinez
Faculty Scholarship
Whether it is a small brokerage firm in Ann Arbor, Michigan, a private university in Cambridge, Massachusetts, or a multinational conglomerate head-quartered in New York City, organizations understand that they are required to fulfill a range of compliance obligations. Compliance programs today tend to have two important characteristics in common. First, the notion that perfect compliance is an impossible goal is a key component of the understandings and expectations of many firms’ compliance programs. Second, organizations have almost uniformly adopted compliance programs in areas where enforcement activity has been significant—like in the areas of antibribery and anticorruption, anti-money laundering, antitrust, …
Crypto Litigation And Market Efficiency, Robert E. Bishop, Bradford Levy, Frank Partnoy, Daniel Taylor, Andrew Yeh
Crypto Litigation And Market Efficiency, Robert E. Bishop, Bradford Levy, Frank Partnoy, Daniel Taylor, Andrew Yeh
Faculty Scholarship
This paper investigates, for the first time in the literature, the factors that should matter to courts in determining whether a crypto market is “efficient,” meaning that prices are sufficiently responsive to information. Based on new empirical evidence and a series of event studies, we recommend a new judicial framework for assessing market efficiency in crypto litigation.
Market efficiency tests based on event studies have played an important role in other areas of litigation, particularly securities litigation, where courts frequently rely on what have become known as the “Cammer factors.” Academics have not yet assessed the extent to which market …
Looking Back On A Successful 2025 At Fhsu, January 1, 2026, Tisa Mason Ed.D.
Looking Back On A Successful 2025 At Fhsu, January 1, 2026, Tisa Mason Ed.D.
Heart of a Tiger Columns
No abstract provided.
Putting The L In Elsi: Legal Methods For Bioethics Research, Anya E R Prince, Benjamin Berkman, Donald Ford, Dov Fox, Christi Guerrini, Amy Koopmann, Natalie Ram, Jessica L Roberts, Kayte Spector-Bagdady, Sonia Suter
Putting The L In Elsi: Legal Methods For Bioethics Research, Anya E R Prince, Benjamin Berkman, Donald Ford, Dov Fox, Christi Guerrini, Amy Koopmann, Natalie Ram, Jessica L Roberts, Kayte Spector-Bagdady, Sonia Suter
Center for Medical Ethics and Health Policy Staff Publications
Lawyers and law professors are increasingly involved in interdisciplinary scientific teams and grant research to answer ethical, legal and policy questions related to biomedical topics. Yet, the methods that lawyers use to conduct legal research and analysis are not always familiar to scientists and social scientists conducting peer review of a proposed project with legal aims or a publication reporting a legal study. To better facilitate interdisciplinary ethical, legal, and social implications collaboration, there is a need to better explain how legal research methodologies can provide robust tools to address a range of nuanced biomedical questions. This paper explores …
Anything But Endo: Diagnostic Buck-Passing In Endometriosis Diagnosis, Rita Dexter, Megan Kitts, Heather Welty, Melanie Jeske
Anything But Endo: Diagnostic Buck-Passing In Endometriosis Diagnosis, Rita Dexter, Megan Kitts, Heather Welty, Melanie Jeske
Center for Medical Ethics and Health Policy Staff Publications
People living with endometriosis, a disease in which tissue similar to the lining of the uterus grows elsewhere in the body, often experience prolonged diagnostic journeys because of symptom variability, normalisation of period pain and other symptoms, and lack of awareness of the condition. In this article, we analyse the endometriosis diagnostic journey through the lens of epistemic injustice. Drawing on in-depth interviews with 52 people living with endometriosis in the United States, we introduce the concept of diagnostic buck-passing to characterise the phenomenon wherein individuals who seek treatment for their symptoms end up stuck in a cycle of seeing …
Do Variations In State Consultation Programs Affect Construction Fatality Rates?, Wayne B. Gray
Do Variations In State Consultation Programs Affect Construction Fatality Rates?, Wayne B. Gray
Economics
Background: Along with its enforcement program, the Occupational Safety and Health Administration (OSHA) has a voluntary consultation program that responds to requests from firms to identify hazards at their workplaces. We studied the effects of this program on fatal work injuries in the construction industry. Methods: We first examined differences across states in their consultation programs using data from 2016 through 2022, during which time 47,418 consultation visits were conducted in construction. These included differences in frequency of consultation visits at construction firms, the average number of hazards identified per visit, and the scope of those visits. We then used …
Exploring Practices Leaders Of Teleworkers Use To Foster Employee Engagement: A Phenomenological Approach, Ronald Eric Snipes
Exploring Practices Leaders Of Teleworkers Use To Foster Employee Engagement: A Phenomenological Approach, Ronald Eric Snipes
Dissertations
Purpose: The purpose of this phenomenological study was to identify and describe the leadership practices used to foster employee engagement among teleworkers in the Veterans Health Administration’s Workforce Management and Consulting division and to examine why leaders believe those practices are important to sustaining employee engagement. The study was guided by the job demands–resources (JD-R) model, which proposes that employee engagement is strengthened when job resources buffer job demands and support motivational processes. As telework continues to expand across organizations, understanding how leadership practices influence engagement in remote environments has become increasingly important.
Methodology: A qualitative phenomenological research design was …
Parental Knowledge And Prevention Perspectives On Hpv, Patti Bell, Roshida Dixon, Marnie Gill, Adrianna Hendrix, Anna Mathis Larson, Briana Quinn
Parental Knowledge And Prevention Perspectives On Hpv, Patti Bell, Roshida Dixon, Marnie Gill, Adrianna Hendrix, Anna Mathis Larson, Briana Quinn
MSN Research Projects
Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide and is responsible for many preventable cancers (Braaten & Laufer, 2008; Centers for Disease Control and Prevention, 2025). Even though a safe and effective vaccine is available, HPV vaccination rates remain lower than desired because of ongoing misinformation, limited knowledge, and parental hesitancy (Aninye et al., 2021; Beavis et al., 2022; Petagna et al., 2024). Since the vaccine is recommended during childhood and adolescence, parents play a major role in the decision to vaccinate (Park et al., 2023; Lopez et al., 2022). The purpose of this study was to …
Skin Cancer Education And Prevention In The College-Age Population, Amanda Altman, Elizabeth Honeycutt-Bolton, Ethan Moore, Kimberly Watkins
Skin Cancer Education And Prevention In The College-Age Population, Amanda Altman, Elizabeth Honeycutt-Bolton, Ethan Moore, Kimberly Watkins
MSN Research Projects
Skin cancer is the most common cancer diagnosed in the United States; although through consistent sun-protective behaviors and early education, it is preventable. Despite the availability of evidence-based prevention strategies, young adults continue to engage in behaviors that increase their risk for ultraviolet (UV) exposure and skin cancer. The purpose of this quantitative descriptive study was to assess skin cancer knowledge, attitudes, and preventive behaviors among college-age students. Guided by Pender’s Health Promotion Model, a cross-sectional survey was distributed to 208 college students between the ages of 18 and 30 years. Data were analyzed using IBM SPSS Statistics Version 30 …
Healthcare Provider Confidence And Practices In Human Trafficking Screening, Regan Moore, Robyn Slaton, Madison Tolbert, Mandy Wedgeworth
Healthcare Provider Confidence And Practices In Human Trafficking Screening, Regan Moore, Robyn Slaton, Madison Tolbert, Mandy Wedgeworth
MSN Research Projects
Human trafficking is a growing public health crisis that affects millions of individuals worldwide and often remains undetected within healthcare settings. Healthcare providers are uniquely positioned to identify trafficked persons; however, limited training, inconsistent screening practices, and lack of confidence hinder effective identification and intervention. The purpose of this descriptive quantitative study was to examine healthcare provider confidence in identifying and reporting trafficked persons and to explore current screening practices and barriers to identification. Data were collected using a 17-question anonymous survey distributed electronically to healthcare providers engaged in direct patient care, including physicians, nurse practitioners, physician assistants, and doctors …
Maintaining Balance And Wellness In Remote Work, Michelle Bartlett
Maintaining Balance And Wellness In Remote Work, Michelle Bartlett
Educational Leadership & Workforce Development Faculty Publications
In today's rapidly evolving work environments, remote work has become more than a trend; it is now a mainstay and rising (Ewers & Kangmennaang, 2023). This shift has necessitated a re-evaluation of traditional work paradigms, particularly in the realms of work-life balance and employee wellness. This chapter details the core strategies for thriving in remote work settings by setting boundaries, combating isolation, and fostering supportive corporate cultures. Transitioning from offices to remote work can blur the lines between personal and professional lives (Bella, 2023; Beňo, 2023). This section provides practical advice on how remote workers can effectively delineate these aspects. …
Partnerships Establishing And Sustaining High-Quality Youth Pre-Apprenticeship: Exploring Key Roles And Skills, Russel L. Parker, James E. Bartlett Ii, Michelle E. Bartlett
Partnerships Establishing And Sustaining High-Quality Youth Pre-Apprenticeship: Exploring Key Roles And Skills, Russel L. Parker, James E. Bartlett Ii, Michelle E. Bartlett
Educational Leadership & Workforce Development Faculty Publications
This study examined the partners, roles, structures, and skills needed to develop and operate successful youth pre-apprenticeship programs for CTE programs and explored how they were evaluated. The purpose of the study is to provide insights for CTE leaders on developing and sustaining youth pre-apprenticeship programs, pathways to apprenticeships to offer youth career opportunities and livable wages without attending four-year colleges. This study highlights the roles partners play in successful youth pre-apprenticeship programs, emphasizing collaboration between education, industry, and communities. It identifies collaborators serving business functions such as leadership, marketing, finance, human resources, customer service, general management, public relations, and …
Neurotensin Drives Theca Cell Migration During Ovulation In Primates, Jessica S. Miller, Megan A. G. Sage, Thomas E. Curry Jr., Diane M. Duffy
Neurotensin Drives Theca Cell Migration During Ovulation In Primates, Jessica S. Miller, Megan A. G. Sage, Thomas E. Curry Jr., Diane M. Duffy
Department of Biomedical and Translational Sciences Faculty Publications
Theca cells are a critical steroidogenic cell type of the ovarian follicle and corpus luteum. The ovulatory luteinizing hormone (LH) surge (or human chorionic gonadotropin (hCG)) stimulates theca cell relocation from the stroma surrounding the dominant follicle to full integration into the developing corpus luteum. Luteinizing hormone/human chorionic gonadotropin also stimulates granulosa cells to produce local mediators of ovulation, including the peptide neurotensin (NTS). To determine if hCG-stimulated NTS regulates theca cell relocation within the ovulatory follicle, vehicle or an NTS receptor antagonist was injected into a macaque dominant follicle, and ovaries were removed 48 h after hCG administration. Additional …
Skeletal Muscle Myofiber Development In Non-Human Primate Offspring Deprived Of Estrogen In Utero, Phillip J. Gauronskas, Terrie J. Lynch, Eugene D. Albrecht, Gerald J. Pepe
Skeletal Muscle Myofiber Development In Non-Human Primate Offspring Deprived Of Estrogen In Utero, Phillip J. Gauronskas, Terrie J. Lynch, Eugene D. Albrecht, Gerald J. Pepe
Department of Biomedical and Translational Sciences Faculty Publications
Introduction: We previously showed that baboon offspring born to mothers deprived of estrogen during the second half of gestation exhibited insulin resistance prior to and after the onset of puberty. Moreover, the size of skeletal muscle myofibers and the number of microvessels important for delivery of insulin/glucose to myofibers were lower in near-term fetuses deprived of estrogen during pregnancy, and myofiber capillarization remained reduced in post-pubertal offspring deprived of estrogen in utero. However, it remains to be determined whether skeletal muscle size is restored to normal in animals deprived of estrogen in utero after the onset of puberty/gonadal estrogen production. …
Dysregulation Of Alternative Splicing Patterns In The Ovaries Of Reproductively Aged Mice, Adnan T. Alsamaraee, Vanessa L. Correll, Julius O. Nyalwidhe, Pavla Brachova, Nehemiah S. Alvarez
Dysregulation Of Alternative Splicing Patterns In The Ovaries Of Reproductively Aged Mice, Adnan T. Alsamaraee, Vanessa L. Correll, Julius O. Nyalwidhe, Pavla Brachova, Nehemiah S. Alvarez
Department of Biomedical and Translational Sciences Faculty Publications
Female reproductive aging is characterized by progressive deterioration of ovarian function, yet the molecular mechanisms driving these changes remain incompletely understood. Here, we used long-read direct RNA-sequencing to map transcript isoform changes in mouse ovaries across reproductive age. Comparing young and aged mice after controlled gonadotropin stimulation, we identified widespread alternative splicing changes, including shifts in exon usage, splice site selection, and transcript boundaries. Aged ovaries exhibited increased isoform diversity, favoring distal start and end sites, and a significant rise in exon skipping and intron retention events. Many of these age-biased splicing events altered open reading frames, introduced premature stop …
Educational Case: Atypical Presentation Of Primary Hyperparathyroidism With Brown Tumor, Ariel Flotte, Jonathan Light, Harrison Klause, Richard M. Conran
Educational Case: Atypical Presentation Of Primary Hyperparathyroidism With Brown Tumor, Ariel Flotte, Jonathan Light, Harrison Klause, Richard M. Conran
Department of Biomedical and Translational Sciences Faculty Publications
The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology.
Brief Pulses Of High-Level Fluid Shear Stress Enhance Metastatic Potential And Rapidly Alter The Metabolism Of Cancer Cells, Amanda N. Pope, Devon L. Moose, Guy O. Hudson, Hank R. Weresh, Marion R. Dykstra, Aabha Y. Joshi, Patrick Breheny, Eric B. Taylor, Michael D. Henry
Brief Pulses Of High-Level Fluid Shear Stress Enhance Metastatic Potential And Rapidly Alter The Metabolism Of Cancer Cells, Amanda N. Pope, Devon L. Moose, Guy O. Hudson, Hank R. Weresh, Marion R. Dykstra, Aabha Y. Joshi, Patrick Breheny, Eric B. Taylor, Michael D. Henry
Department of Biomedical and Translational Sciences Faculty Publications
Circulating tumor cells (CTCs) face challenges to their survival, including mechanical and oxidative stresses that are different from cancer cells in solid primary and metastatic tumors. The impact of adaptations to the fluid microenvironment of the circulation on the outcome of the metastatic cascade is not well understood. Here, we find that cancer cells exposed to brief pulses of high-level fluid shear stress (FSS) exhibit enhanced invasiveness and anchorage-independent proliferation in vitro and enhanced metastatic colonization/tumor formation in vivo. Cancer cells exposed to FSS rapidly alter their metabolism in a manner that promotes survival by providing energy for cytoskeletal remodeling …
Localization And Functional Exploration Of Leiomodin-2'S C-Terminal Binding Sites, Mason D. Summers, Madison Little, Robert P. Young, Brayan Osegueda, Alan Palma Guillen, Garry E. Smith Jr., John R. Cart, Vitold E. Galkin, Alla S. Kostyukova
Localization And Functional Exploration Of Leiomodin-2'S C-Terminal Binding Sites, Mason D. Summers, Madison Little, Robert P. Young, Brayan Osegueda, Alan Palma Guillen, Garry E. Smith Jr., John R. Cart, Vitold E. Galkin, Alla S. Kostyukova
Department of Biomedical and Translational Sciences Faculty Publications
Striated muscle contraction occurs through interactions between overlapping myosin-based thick and actin-based thin filaments within the sarcomere. For effective contraction to occur, the length of the thin filament must be maintained to ensure sufficient overlap with the thick filament. The proteins leiomodin and tropomodulin compete for binding at the pointed ends of thin filaments to regulate their length, using their homologous N-terminal actin and tropomyosin binding sites. Leiomodin also contains a region called the C-terminal extension, absent in tropomodulin. In this region, the cardiac isoform (leiomodin-2) contains additional actin-binding sites that enable it to bind along the sides of thin …
Stat4-Dependent Regulation Of Neuroinflammation In Atherosclerosis, Natalie Stahr, Alina K. Moriarty, Shelby D. Ma, W. Coles Keeter, Woong-Ki Kim, Larry D. Sanford, Elena V. Galkina
Stat4-Dependent Regulation Of Neuroinflammation In Atherosclerosis, Natalie Stahr, Alina K. Moriarty, Shelby D. Ma, W. Coles Keeter, Woong-Ki Kim, Larry D. Sanford, Elena V. Galkina
Department of Biomedical and Translational Sciences Faculty Publications
Atherosclerosis is linked to an increased risk of cognitive decline, with chronic inflammation being a common feature of both pathologies. IL-12 activates STAT4 to regulate myeloid cell functions, and blockade of this pathway alleviates cognitive impairment in Alzheimer's models. However, the mechanisms connecting vascular pathology to neuroinflammation remain unclear. Here, we examine whether STAT4 functions as a common mediator of neuroinflammation in atherosclerosis. We demonstrate that LysMCre-specific STAT4 deficiency ameliorates deficits in long-term memory in low-density lipoprotein-deficient (Ldlr-/-) mice fed a high-fat diet (HFD-C). STAT4 deficiency moderately reduces Ser199-phosphorylated Tau burden. Atherosclerosis alters brain immune …
Estrogen Deprivation During Primate (Papio Anubis) Pregnancy: Impact On Systemic Microvascular Flow And Cardiovascular Development And Function After Birth In Offspring, Sifa Turan, Jeffery S. Babischkin, Graham W. Aberdeen, Gerald J. Pepe, Eugene D. Albrecht
Estrogen Deprivation During Primate (Papio Anubis) Pregnancy: Impact On Systemic Microvascular Flow And Cardiovascular Development And Function After Birth In Offspring, Sifa Turan, Jeffery S. Babischkin, Graham W. Aberdeen, Gerald J. Pepe, Eugene D. Albrecht
Department of Biomedical and Translational Sciences Faculty Publications
Background
Suppressing estradiol (E₂) during baboon pregnancy lowers offspring skeletal muscle capillary density, vital for insulin-mediated glucose uptake, and induces insulin resistance. We examined whether E₂ deprivation also impairs microvascular flow and cardiac function.
Methods
Offspring of untreated baboons, letrozole-treated baboons, or letrozole plus E₂ (maternal s.c. injections during the second half of gestation) underwent contrast-enhanced microbubble ultrasonography to quantify microvessel flow and echocardiography to assess cardiac performance.
Results
Letrozole reduced maternal serum E₂ by 95% (p < 0.01). In letrozole offspring, microbubble flux rate (β) fell 55% (p < 0.02), replenishment was 5 s slower (p < 0.03), and microvessel flow declined 40% (p = 0.05); all were restored by added E₂. Indices of systolic (isovolumic contraction), diastolic (isovolumic relaxation), global performance (Tei index), and cardiac output were unchanged.
Conclusion
Prolonged gestational E₂ deprivation programs a reduction in microvascular flow without altering cardiac function; maternal E₂ prevents this, supporting E₂'s role in …