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The Role Of Vitamin D In Management Of Pediatric Chronic Immune Thrombocytopenia, Eman Magdy Yahia, Suzy Abd El Mabood Abd El Hameed, Dalia Tawfeek Hussein, Amany Mamdouh Shoumah

Mansoura Medical Journal

In children, immune thrombocytopenia (ITP) remains a serious health concern, which is an autoimmune disorder (AID) characterized by an isolated decrease in platelet count, leading to an increased risk of bleeding.

The use of vitamin D supplementation represents a turning point in many autoimmune diseases, with the potential to deliver high cure rates with fewer side effects than previous therapies. In this review, we explore the incidence of ITP , immunopathogenesis, diagnosis and management in pediatric patients. We will discuss the mechanisms of action of vitamin D , focusing on its role in autoimmune diseases especially ITP

Predictive Value Of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio And Ca-125 Dynamics After Neoadjuvant Chemotherapy For Surgical Outcomes And Prognosis In Ovarian Cancer, Asmaa S. Othman, Hend M. Serya, Manar H. Ahmed, Asmaa F. Elfayoumey

Mansoura Medical Journal

Background: The prognosis of patients with advanced-stage epithelial ovarian cancer (EOC) having debulking surgery is greatly influenced by optimal resection. Neutrophil-to-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and CA-125 values are examples of inflammatory markers that have been identified as possible predictive markers.

Objective: This study evaluated neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and CA-125 dynamics as predictors of surgical outcomes and survival in advanced ovarian cancer patients receiving neoadjuvant chemotherapy (NACT).

Methods: We conducted a retrospective analysis of 171 patients treated at Mansoura University (2020-2025) with platinum-taxane neoadjuvant chemotherapy followed by interval debulking surgery (IDS). Pre- …

Effect Of Graft Steatosis On The Early Outcome Of Living Donor Liver Transplantation, Kareem Maher Shams Eldeen Hassan, Ahmed Mahmoud Abdelrafee, Ahmed Mohamed Ibrahim Elsabbagh, Mohamed Abd Elwahab Ali

Mansoura Medical Journal

Background

Hepatic steatosis in donor grafts represents a growing challenge in living donor liver transplantation (LDLT) due to the rising prevalence of metabolic syndrome. The impact of varying degrees of graft steatosis on recipient and donor outcomes remains incompletely defined.

Aim

To evaluate the effect of different degrees of graft steatosis on early postoperative outcomes in both recipients and donors following LDLT.

Methods

This retrospective study analyzed 169 LDLT cases performed at Mansoura University between January 2014 and June 2024. Donors aged 18-45 years with BMI≥5% on liver biopsy were included. Grafts were stratified by steatosis degree:20% (n=4). Primary outcome …

Impact Of Covid-19 Infection On Left Ventricular Systolic And Diastolic Functions., Hazem Galal Mohamed, Maged Zaghloul Mohamed Amer, Aml Fathy Moustafa, Shady Hussein Mohamed

Mansoura Medical Journal

Background: SARS-CoV-2, the pathogen behind COVID-19, often involves the cardiovascular system due to high ACE2 receptor density in myocardial tissue. While immediate cardiac complications are recognized, the persistent effects on left ventricular (LV) performance require further investigation through echocardiography.

Aim: This study aimed to comprehensively describe the sequelae of COVID-19 infection on the left ventricle using echocardiography

Methods: The study included 100 participants. Cardiac function was assessed using a standard 12-lead ECG and transthoracic echocardiography. LV systolic function was evaluated using the Biplane Simpson Method, and myocardial contractility was further analyzed using Speckle-Tracking Echocardiography (STE).

Results: The mean age was …

Effect Of Graft Weight On Splenic Volume After Living Donor Liver Transplant, Raghda Adel Mohammed, Amina Ahmed Sultan, Eman Mohammed Helmy, Mohamed Samy Habl

Mansoura Medical Journal

Background: In recipients of liver transplantation (LT), spleen volume reflects the portal hemodynamic status. Optimization of graft weight and studying its effect on the outcomes on the splenic volume after the transplant is one of the techniques for portal inflow modulation.  Aim: The study aims to assess the degree of splenic volume reduction after living donor liver transplantation in correlation to graft weight. Methods: The study analyzed 29 liver transplantation patients, involving comprehensive history taking, clinical examination, and laboratory data assessment. Spleen volume has been measured via a semi‑automatic region‑based technique with subsequent manual refinement when necessary to accurately delineate …

Patterns Of Bilirubin Decline After Biliary Stenting In Malignant Obstructive Jaundice, Omar Abdallah, Shymaa Abdelghany, Mohamad A. Ebrahim, Hassan Atalla

Mansoura Medical Journal

Background: Malignant extrahepatic biliary obstruction (MEBO) is a common cause of obstructive jaundice associated with high morbidity and mortality. ERCP-guided biliary drainage is widely used for palliative management, however, real-world data regarding bilirubin decline and predictors of success remain limited. This study aimed to evaluate bilirubin decline patterns, clinical outcomes, and predictors of clinical success following ERCP-guided biliary drainage in patients with MEBO.

Methods: This prospective observational study included consecutive MEBO patients who underwent ERCP-guided biliary drainage either by plastic or metallic stents at a tertiary-care hospital. Technical success, defined as successful stent placement, and clinical success, defined as symptomatic …

Role Of Positron Emission Tomography-Computed Tomography (Pet-Ct) In Evaluation Of Hepato-Cellular Carcinoma, Mona Baz, Ahmed Youssef Kandeel, Mohamed Ali El-Adalany, Dina El-Metwally

Mansoura Medical Journal

Background: Globally HCC appeared to be the third main reason of mortality associated with cancer.  According to degree of differentiation, HCC can be classified into four grades. PET/CT represents a functional imaging technique that offers metabolic insights into the tumor. It may play a substantial turn in prediction of biological behavior of HCC, predicting tumor grade and presence of microvascular invasion.

Aim of the work:  This work aimed to assess the utility of 18F-FDG PET/CT in identification of primary hepatocellular carcinoma (HCC) and in predicting its histological grade.

Methods: A total of 52 patients with established HCC were included in …

Clinical Outcomes Of Ultrasound-Guided Tmj Arthrocentesis In Post-Traumatic Internal Derangement: A Prospective Single-Arm Clinical Study, Ahmed Emad Mohamed Ghaly, Nabil Mokhtar Mohammed, Mohamed Radwan Elhadidy, Mohammed Hassan El Fahar

Mansoura Medical Journal

Background: The most common condition is temporomandibular joint (TMJ) internal derangement (ID). common TMJ disorder. It is defined as an abnormal displacement of the articular disc from its normal position relative to the condyle during joint function.

Aim: To evaluate the clinical outcomes of ultrasound-guided temporomandibular joint (TMJ) arthrocentesis in patients with post-traumatic internal derangement, the effectiveness of the procedure in reducing pain intensity, improving mandibular range of motion (maximum mouth opening and lateral excursions), decreasing TMJ clicking, and determining the overall clinical success rate over a 6-month follow up period.

Patients and methods: This prospective single-arm non-randomized study was …

Epidemiologic, Clinical And Genetic Characteristics Of Familial Mediterranean Fever In Egyptian Children’S Tertiary Care Center, Ghada Ahmed Elsayed Mgahed, Mayada Sabry Zeid, Ali Sobh, Shaltout A

Mansoura Medical Journal

Background: Familial Mediterranean fever (FMF) is an inherited disorder known by recurrent, brief, and self-limiting episodes of fever and serosal inflammation. It is primarily defined by acute inflammatory involvement of serosal membranes, including the pleura, peritoneum, and/or synovial tissues, typically associated by fever. This inflammatory cascade is inherently self-propagating and, if inadequately controlled, may lead to recurrent episodes or sustained inflammatory activity.

Aim of the work: To examine the clinical and demographic characteristics of individuals with childhood- initiation FMF, to determine the prevalence of the most frequent mutations in the FMF-linked gene within this population, and to assess the …

Impact Of Early Injection Laryngoplasty On Voice Outcomes And Quality Of Life In Acute Unilateral Vocal Fold Paralysis, Abdelrhman Ali Kamal, M El-Kotb, Hemmat Mostafa Baz, Ahmed S. Abdelmeguid

Mansoura Medical Journal

Background

Unilateral vocal fold paralysis (UVFP) leads to glottic insufficiency, resulting in dysphonia, reduced vocal strength, and frequently swallowing difficulties that impair communication and quality of life. Injection laryngoplasty with temporary materials such as hyaluronic acid has been shown to improve voice quality and phonatory function in UVFP patients and may serve as an effective early intervention prior to permanent medialization surgery.

Objective

To assess the impact of early injection laryngoplasty on voice outcomes and voice related quality of life in patients with acute unilateral vocal fold paralysis.

Methods

This prospective study included 24 patients with acute UVFP treated with …

Predictors Of Outcomes Of Adult Mandibular Fractures: A Prospective Study., Norhan Yahia El-Henawy, Mohamed Ali Mahgoub, Mohamed Radwan El-Hadidy, Ahmed Hassan El-Sabbagh

Mansoura Medical Journal

Background: Mandibular fractures not only cause physical disfigurement and functional impairments but also significantly affect the patient’s psychological, emotional, and social well-being. Predictors are variables that may influence or explain variation in the outcome of mandibular fracture. Aim of work: To evaluate demographic, clinical, radiological, and psychosocial factors associated with early postoperative complications and postoperative depressive symptoms following surgical management of adult mandibular fractures. Methods: A prospective study evaluated patients who will undergo treatment for surgical mandibular fracture/s at Mansoura Emergency Hospital, DK, from August 2023 to July 2024. The patients were assessed by history taking, clinical picture, radiological tools, …

Red Cell Distribution Width As A Prognostic Factor And Its Comparison With Lactate In Patients With Sepsis: An Observational Prospective Cohort Study, Ahmed Taha Gad, Ghada Fathy El-Rahmawy, Naglaa Abd El-Latif El-Negeery, Eiad Ahmed Ramzy

Mansoura Medical Journal

Background: Red blood cell distribution width (RDW) is a straightforward and cost-effective parameter that is utilized in laboratory hematology to differentiate anemias. It is indicative of the grade of heterogeneity in erythrocyte volume. This study purpose examine the correlation among the risk of adverse results in patients with sepsis and RDW, as well as to equivalence the mortality discriminative capacity of RDW and lactate levels.

Methods: This observational prospective cohort study was done on 67 sepstic patients aged ≥ 21 years old, both sexes. Patients were owed into two groups according to RDW levels: Group A (n=35): normal RDW …

The Role Of Adult Appendicitis Score In Reducing The Negative Appendectomy Rate, Mohamed Mahmoud Mansour El Ghzzawy, Magdy Basheer, Mohamed Balata, Amir A. Fikry

Mansoura Medical Journal

Aim: Approximately 15 – 30% of all acute appendectomies are performed based only on clinical suspicion. A negative appendectomy has a 10–12% morbidity rate, which could be detrimental to patients. The current study aimed to evaluate the effectiveness of adult appendicitis score (AAS) in accurate identification of cases with acute appendicitis.

Patients and Methods: This prospective observational study was conducted on 150 patients who presented with manifestations of acute appendicitis admitted to Mansoura Emergency Hospital.  The AAS was calculated, the decision on appendectomy was solely based on the surgeon’s clinical judgment after taking into consideration all the findings of clinical, …

Laparoscopic Versus Open Redo Anti-Reflux Surgery, Mohamed Barkok, Mohammed Said, Ahmed Shehta, Abdel-Raouf El-Geidie

Mansoura Medical Journal

Background

Gastroesophageal reflux disease (GERD) is common. Laparoscopic fundoplication became the gold standard for GERD surgery after medical treatment failed. If a previous anti-reflux surgery fails, redo surgery requires a thorough review to determine the cause and a skilled surgical team. Choosing the optimal approach during the redo surgeries, whether open or laparoscopic hasn’t been previously illustrated.

Aim

To compare the outcomes of laparoscopic versus open redo anti-reflux surgeries.

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Patients and methods

This study included 28 patients who underwent redo anti-reflux surgery. The patients were divided according to the approach into laparoscopic (n = 11) and open (n = …

Cracking The Code Of Ai Autonomy: Examining The Role Of Challenge And Hindrance Appraisals And Ai Literacy In Task Satisfaction, Rujuta Parekar

Graduate Studies Theses and Dissertations 2026

AI is constantly evolving and being rapidly integrated into the workplace. Limited research has examined how this integration is affecting employee outcomes, and particularly the impacts of whether employees are expected or mandated to use AI for their work. The present study utilized the challenge-hindrance framework to examine the effect of autonomy in using AI on task satisfaction through challenge and hindrance appraisal among working adults. Since the ability to understand and use AI can influence how individuals perceive it, the moderating effect of AI literacy on the hypothesized research model is also examined. A multi-wave research design was used …

Beyond The Square Pulse: Waveform Shape, Eeg Correlates, And The Pursuit Of Natural Sensation In Tens, Jason Whitson

Honors Undergraduate Theses

This study investigates the relationship between electrical stimulus characteristics of shape and charge on evoked sensations and electroencephalogram (EEG) data during multi-waveform transcutaneous electrical nerve stimulation (TENS) of the median nerve. Neuromodulation methods have traditionally had little control over the location and quality of their associated evoked sensation (e.g., electric, vibration, touch). This experiment utilized five unique stimulus waveforms during TENS stimulation. EEG data were collected concurrently to provide an introductory objective measure of the neural responses underlying these sensory changes. Eleven participants completed three tasks (thresholding, super-threshold stimulation, two-alternative forced choice) using a two-electrode TENS approach. Stimulus waveforms were …

Exploring Associations Between Mental Disorder And Creativity, David A. Romero Mora

Honors Undergraduate Theses

Mental disorder has been misunderstood and misrepresented throughout history, leading mental health research to be severely behind where it needs to be. Years of misinformation, over-medicalization, negative rhetoric, and stigmatization at the hands of the very same institutions that were believed to care for mental disorder have kept this misunderstanding alive. Further, studies throughout history have failed to look at the nuances of mental health, prioritizing generalizability. This thesis explores the relationship between mental disorder and creative expression, how other factors like cultural discourse and cognitive processes inform this relationship, as well as how analyzing this relationship can provide a …

Bilingualsim In The Workplace: How Work Attitudes Influence Burnout And Turnover Intentions, Andrea Del Aguila

Honors Undergraduate Theses

Understanding whether language status functions as a risk or protective factor for employee well-being and retention is essential for developing organizational policies that support workers from varied demographic backgrounds. This study examined how work attitudes such as job satisfaction, organizational commitment, and work engagement are seen among bilingual and monolingual workers and how these outcomes relate to employee burnout and turnover intentions. An outside researcher from Talent Metrics Consulting collected data via an online survey utilizing previously validated measures of job satisfaction, organizational commitment, burnout, work engagement, and turnover intentions. Participants were recruited through online advertising and social sampling obtaining …

Comparative Analysis Of Left Ventricular Sympathetic Axons In Shr And Wky Rats, Parker R. Tyson

Honors Undergraduate Theses

Hypertension is a leading cause of cardiovascular morbidity and mortality and is strongly associated with dysregulation of the sympathetic nervous system, which plays a central role in controlling heart rate, vascular tone, and blood pressure. Although increased sympathetic activity has been widely documented in hypertensive disease, the precise structural organization of sympathetic innervation within the hypertensive heart remains incompletely characterized. This study investigates whether chronic hypertension is associated with structural remodeling of sympathetic axons in the left ventricle by comparing autonomic innervation patterns between spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY). Hearts were collected following transcardial perfusion …

Complexity Theory And Environmental Conservation Management: A Case Study With Coyote And Red Wolf Hybridization, Gretchen E. Mahalic

Honors Undergraduate Theses

Conservation biology and invasion biology are value-led scientific disciplines founded on environmental advocacy, operating at the intersection of research and action. Though these disciplines are known for their scientific veracity, unexamined values are often promulgated without scrutiny and drive decisions that work against good ecological outcomes. A case in point is that coyotes migrating into southeastern territory are framed as the greatest threat to the conservation of the endangered red wolf because hybridization is seen as diminishing their species integrity. Applying Val Plumwood’s ecofeminist account of dualistic frameworks, I will use this case to show how the vilification of the …

A Chicken Model For Non-Invasive Diagnosis Of Infant Developmental Dysplasia Of The Hip (Ddh) Using Acoustic Transmission Measurements, Aliza Shah

Honors Undergraduate Theses

Developmental dysplasia of the hip (DDH) is a condition characterized by abnormal development and stability of the hip joint. In a healthy infant, the femoral head (ball) fits securely within the acetabulum (socket of the pelvis), allowing for proper joint function. In DDH, the relationship is disrupted, ranging from mild acetabular dysplasia to partial (subluxation) or complete dislocation of the femoral head. This condition represents a range of structural abnormalities that develop during early growth. The integrity of the hip joint is essential for physical mobility, and disruption of this structure can lead to significant functional impairment. DDH may result …

Investigating The Role Of Traditional Chinese Herbal Medicine For Cancer Symptom Management In Older Adults: A Rapid Review, Isabelle C. Karshner

Honors Undergraduate Theses

Background: Patients with cancer often experience symptoms related to disease, complications, and treatment. One potential method of alleviating these symptoms is traditional Chinese herbal medications (TCHM). This rapid review explores the role of traditional Chinese herbal medications in treating cancer-related symptoms in older adults.

Purpose: The purpose of this rapid review is to gain and provide a better understanding of the effects of TCHM on cancer-symptom management in the older adult population. This review explores the association between TCHM and effects on cancer symptoms in older adults, including interactions, toxicity, and signs/symptoms of TCHM use that may be useful information …

Synthesis And Characterization Of Succinate Dehydrogenase Inhibitors H2/Z14 And C6/Z96 In Order To Combat Small Cell Lung Cancer, Lauren M. Graves

Honors Undergraduate Theses

The use of ubiquinone inhibitors to combat cancer is a recent development in medicinal science and procedures to efficiently synthesize these drugs remain limited. C6/Z96 and H2/Z14, two succinate dehydrogenase inhibitors, have been previously tested in vitro against NSCLC with positive results. Their similarity to ubiquinone is what makes them a strong candidate for a succinate dehydrogenase inhibitor at the ubiquinone binding site. The heterocyclic scaffolds and substituents are proposed to bind strongly through a combination of electronics, hydrogen-bonding, and fit, allowing them to bind well and prove to be more favorable than ubiquinone when competing for the Q-site. By …

Navigating Mental Wellness: A Peer-Led Journey Into Adult Services, Kristin G. Haberek

DSW Capstone Projects

Students with severe emotional disturbances (SED) occupy one of the most underserved intersections in American education and mental health care. As they age out of children’s services, they face abrupt service discontinuation, disrupted therapeutic relationships, and adult systems ill-equipped to meet their needs. These vulnerabilities, including heightened risks of crisis, hospitalization, homelessness, and justice involvement, constitute a central practice problem. This capstone addresses these transitions across three scholarly products: a systematic literature review, a theoretical concept paper, and a practical application paper, tracing a unified arc from diagnosing structural failures to proposing an evidence-informed, equity-oriented clinical response. Synthesizing key findings …

Recruitment Agency-Mediated Onboarding, Acculturation, And Contract Completion Among Internationally Educated Nurses In The United States: A Questionnaire Survey, Jasper Erwin Tolarba, Jennifer Orbeso, Reynaldo R. Rivera

Nursing Faculty Publications

Background

Internationally educated nurses play a vital role in addressing global nursing workforce shortages and supporting healthcare systems across many high-income countries. As international nurse migration continues to increase worldwide, effective transition, onboarding, and acculturation practices have become important determinants of workforce integration and retention. In the United States, internationally educated nurses comprise a growing segment of the nursing workforce; however, variability in onboarding practices may affect successful integration and retention.

Aim

To examine recruitment agency–mediated onboarding and acculturation practices and their association with contract completion among internationally educated nurses in the United States.

Design

Cross-sectional descriptive correlational study.

Methods …

The Effect Of In-Game Cervical Exercises On Shoulder Internal Rotation Range Of Motion And External Rotator Strength In Baseball Pitchers, Vincent Ceasrine, Christine Ferraro, Jason K. Grimes

Physical Therapy Faculty Publications

Background

Consensus is lacking regarding the underlying cause of two prevalent risk factors for shoulder and elbow pain in overhead throwing athletes: loss of shoulder internal rotation (IR) range of motion (ROM) and strength of the external rotators (ER). Consideration of cervical spine contribution may have important implications for rehabilitation and coaching of overhead throwers.

Purpose

The purpose of this study was to investigate the effect of performing active cervical retraction and retraction with extension exercises between innings of pitching a simulated game on shoulder IR ROM and ER strength following completion of the game.

Study Design

Randomized controlled study …

Beyond Weight Loss: Effects Of Trx Suspension Training Combined With Caloric Restriction On Thyroid Function And Mental Well-Being In Obese Hypothyroid Women, Siavash Naddafha, Christopher Taber

Physical Therapy Faculty Publications

Background

The rate of metabolism decreases in hypothyroid patients; hypothyroidism is associated with body mass increases; due to this and other factors, depression, anxiety, and stress increase, which, alongside the disease state and psychological problems, causes the quality of life to suffer.

Objectives

The purpose of this research is to investigate the effect of caloric restriction along with TRX exercise on body mass, thyroid hormones, and psychological measures in obese and overweight women with hypothyroidism.

Methods

34 women aged 18–50 with hypothyroidism and a body mass index above 25 participated in this study. They were divided into three groups: a …

A Test Of The Three-Step Theory: Examining Pain, Hopelessness, And Suicidal Desire Among College Students, Shelby Baker

Graduate Studies Theses and Dissertations 2026

Suicide is a leading cause of death, and suicidal thoughts are prevalent among emerging adults and undergraduate students. Still, many prominent risk factors remain understudied. Guided by the Three-Step Theory of Suicide (3ST), this study examined the roles of hopelessness, psychological pain, and physical pain in prediction of suicidal desire among undergraduate college students (N = 1,705) recruited from UCF’s SONA system and CloudResearch’s Connect platform. Participants completed an online, cross-sectional survey that included measures of suicidal thoughts and behaviors, hopelessness, psychological pain, physical pain, and other psychological variables of interest. Psychological pain and physical pain were tested as moderators …

Holistic Review In Graduate Admissions: Admissions Professionals’ Evaluation Of Non-Cognitive Traits, Joshua L. Olson

Graduate Studies Theses and Dissertations 2026

This basic qualitative study examines how graduate admissions professionals conceptualize, operationalize, and interpret holistic review within graduate admissions processes. Guided by Social Cognitive Theory and Expectancy-Value Theory, the study explores how non-cognitive traits such as motivation, resilience, self-efficacy, and professionalism are evaluated alongside traditional academic indicators in admissions decision-making. Using semi-structured interviews with graduate admissions professionals directly involved in admissions decisions, the study identifies how holistic review is defined and implemented across institutional contexts, which non-cognitive traits are most valued, and the tools and procedures used to assess applicant potential beyond academic metrics. Findings suggest that, for participants in this …

Come And See: Exploring Complex Dynamics And Abjection Through A Southern Gothic Family Portrait, Lenee N. Peterson

Graduate Studies Theses and Dissertations 2026

“COME AND SEE: Exploring Abject Theory Through a Southern Gothic Family Portrait” examines the artist’s complex familial upbringing through the visual and narrative traditions of Southern Gothic art. Drawing upon abject theory and the cultural references of folk horror and Southern Gothicism, this thesis positions the family portrait where intimacy, trauma, and cultural inheritance collide. The project argues that direct confrontation with abjection can foster recognition, shared experience, and the possibility of collective healing. Grounded in practice-based research, this work functions as a critical and creative response to familial strain shaped by scarcity, social oppression, and emotional precarity. Through a …