Digital Commons Network^™

Barriers And Facilitators To Recruiting Older Adult Care Homeresidents Into Clinical Trials Of Medicines And Vaccines: A Scoping Review, Selvarani Subbarayan, Imogen A. Smith-Dodd, Gabriel Nicolson, Jennifer K. Burton, Janet T. Scott, Seshadri S. Vasan, Susan D. Shenkin, Roy L. Soiza, The Watch Consortium

Research outputs 2022 to 2026

Introduction: Excluding Care Home (CH) residents from clinical trials of medicines and vaccines has led to an evidence gap. Findings from younger adults may not be generalisable to CH residents with frailty and dementia. Therefore, it is essential to evaluate pharmacological treatments directly in CH residents to assess their safety and efficacy.

Methods: As part of the Widening Access to Trials in Care Homes project, we conducted a scoping review using Joanna Briggs Institute methodology to identify barriers and facilitators to recruiting CH residents into clinical trials of medicinal products. We searched EMBASE, MEDLINE, PsycINFO, CINAHL, and the Cochrane Library …

A Mass Cytometry-Based Blood Cell Phenotyping Workflow Enabling Inclusion Of Resource-Limited And Rural Sites In Immune System Studies, Natalie J. Smith, Michael Cohen, Lauren Tracey, Julie Alipaz, Christina Loh, David King, Neha Pulyani, Rebecca Auzins, Elin Gray, Sandra Taylor, Rajat Rai, Steven Kao, Barbara Fazekas De St Groth, Helen M. Mcguire

Research outputs 2022 to 2026

Insight into disease detection and treatment through comprehensive immune phenotyping relies on the generation of high-quality data. However, the execution of robust immune monitoring in clinical trials by flow cytometry is complex due to logistical challenges in sample preparation and reagent stability. These challenges are exacerbated when considering remote and rural communities in Australia, which are burdened by both an increased prevalence and a worse prognosis of many chronic and infectious pathologies. This is not unique to the Australian context as globally remote and rural communities are underrepresented in biomedical research studies, contributing to persistent health inequities. To address these …

Exploring The Las-Vict Principle Of Cryptocurrency Exchanges: A Belief–Action–Outcome Perspective, Cheuk Hang Au, Kevin K.W. Ho, Po Hsu Shieh, Kris M.Y. Law

Research outputs 2022 to 2026

Purpose – Cryptocurrency exchanges operate in a hyper-volatile, “wild west” environment, fundamentally challenging existing theories of FinTech success that were built for stable markets. The literature lacks a framework to explain how firms thrive amidst such extreme regulatory ambiguity and institutional distrust. This study resolves this theoretical puzzle by developing a new principle for success in nascent, high-stakes digital ecosystems. Design/methodology/approach – We conduct a multiple-case study of 14 leading cryptocurrency exchanges. Using the belief–action–outcome (BAO) logic as an analytical guide, we deconstruct the strategic actions that separate successful exchanges from failures, synthesising them into a new, empirically grounded framework. …

Influence Of Isometric Hamstring Assessment Modality: Asymmetries Across Bilateral And Unilateral Testing Procedures, Adam E. Sundh, Nicholas J. Ripley, A. J. Lamb, Conor J. Cantwell, Paul Comfort

Research outputs 2022 to 2026

Purpose: The aim of this study was to evaluate whether unilateral and bilateral assessments display comparable results during the isometric long-lever bridge and to examine the directionality of asymmetry fluctuations across testing occasions. Methods: Forty-four participants comprising of 30 men (age: 19.4 ± 1.3 years; height: 179.8 ± 6.3 cm; body mass: 80.4 ± 10.3 kg) and 14 women (age: 20.0 ± 1.3 years; height: 166.9 ± 7.2 cm; body mass: 64.4 ± 7.4 kg) volunteered to participate in the study. All participants completed two separate testing sessions consisting of two maximal bilateral and unilateral repetitions respectively of the isometric …

Beyond Teaching: Black And Hispanic Calculus Students Describe Interactions With Faculty, Kevin A. Palencia Infante, Ricela Feliciano-Semidei, Alcibiades Bustillo-Zarate, Ke Wu

Faculty Articles, Papers, and Other Scholarship

The experiences of underrepresented minority (URM) students in science, technology, engineering, and mathematics (STEM) programs provide valuable insights into improving their retention and academic achievement. This study investigates how Black and Hispanic calculus students describe faculty-student interactions. Four students participated in a demographic survey and follow-up interviews, sharing their experiences with calculus learning. Using thematic coding guided by validation theory, the data revealed instructors’ academic practices that either validated or invalidated students’ participation in calculus classes. These practices include cultivating in-class conceptual support, promoting collaborative learning spaces, demonstrating out-of-class academic availability, acknowledging and integrating diverse student experiences, and encouraging metacognitive …

The Impact Of Defunding The Supplemental Nutrition Assistance Program Education (Snap-Ed) In Louisiana, Virginia Bordelon, Senlin Chen, Yuxin Nie, Denise Holston, Jessice Stroope

Distinguished Undergraduate Researcher Program

The Supplemental Nutrition Assistance Program Education (SNAP-Ed) was a federally funded initiative that aims to improve nutrition knowledge, promote physical activity, and provide education through Policy, System, and Environmental (PSE) strategies. This study examined the relationship between the defunding of SNAP-Ed and how nutrition and physical activity were affected among low-income families. Data for this study originated an interview with a Department of Children and Family Services (DCFS) economist, an interview with SNAP-Ed field agent, and survey responses from 32 adult participants familiar with SNAP. The SNAP recipients use the education program resources to assist in healthy recipes, physical
education …

Low Burden Of Clinically Relevant Anaemia And Thrombocytopenia Among Adolescents Living With Hiv Receiving Tenofovir/Lamivudine Plus Dolutegravir: The Cipher-Adola Study In Cameroon, Nadine Nguendjoung Fainguem, Yagai Bouba, Rachel Kamgaing, Jeremiah Efakika Gabisa, Aude Christelle Ka’E, Michel Carlos Tommo Tchouaket, Alex Durand Nka, Cynthia Ayafor, Lum Forgwei, Upal Roy

Health & Biomedical Sciences Faculty Publications

Background: Anaemia and thrombocytopenia adversely affect adolescent HIV outcomes, yet adolescent-specific data from the tenofovir/lamivudine/dolutegravir (TLD) era remain scarce, and access to full blood count (FBC) testing is limited in Cameroon. We evaluated the prevalence, severity, and factors associated with these cytopenias among adolescents living with HIV (ADLHIV) in the TLD era.

Methods: Multicentre cross-sectional study was conducted among ADLHIV (10-19 years) receiving TLD in the CIPHER-ADOLA cohort in Cameroon. Full blood count, viral load (VL) and CD4-count were performed. Factors associated with anaemia and thrombocytopenia were ascertained.

Results: A total of 252 ADLHIV was enrolled (50.8% male, 83.3% were …

Apoe4 Drives Maladaptive Heterogeneity And Immunometabolic Responses Of Astrocytes, Danielle S. Goulding, Holden C. Williams, Amy A. Gorman, Nicholas A. Devanney, Douglas A. Harrison, Adeline E. Walsh, Tony Tuck, Diana J. Zajac, Shannon L. Macauley, Steven Estus, Julia Tcw, Lance A. Johnson, Josh M. Morganti

Sanders-Brown Center on Aging Faculty Publications

Apolipoprotein E4 (APOE4) is the strongest risk allele associated with the development of late onset Alzheimer’s disease (AD). Across the CNS, astrocytes are the predominant expressor of APOE while also being critical mediators of neuroinflammation and cerebral metabolism. APOE4 has been consistently linked with dysfunctional inflammation and metabolic processes, yet insights into the molecular constituents driving these responses remain unclear. Utilizing complementary approaches across humanized APOE mice and isogenic human iPSC astrocytes, we demonstrate that ApoE4 alters the astrocyte immunometabolic response to pro-inflammatory stimuli. Our findings show that ApoE4-expressing astrocytes acquire distinct transcriptional repertoires at single-cell and spatially-resolved domains, which …

Applying Photovoice To Uncover Fundamental Causes Of Health Inequality In Local Health Contexts, Marisa Booty, Madelyne G. Culbertson, Mason Taylor, Dakota Heise, Heather Stone, Katherine Leanne Kommer, Jennifer Gulley, Jeanette Hart, Christina Nentwick, Margaret Mcgladrey

Sociology Faculty Publications

Introduction: Participatory action research methods like Photovoice are uniquely equipped to identify structural determinants of health based on lived experiences of how they influence proximal and distal population health outcomes. This study uses Photovoice data to examine how structural determinants impact community health needs.

Methods: Qualitative thematic analysis used focus group discussion data (25 transcripts) from four Kentucky counties that embedded Photovoice into their local health department community health assessment processes. Coded excerpts were examined for ways in which participants' community health concerns reflected structural issues rather than individual health behaviors.

Results: Participants perceived issues such as houselessness, food insecurity, …

Factors Associated With Handgun Carriage Among U.S. Adolescents, 2021–2022, Marisa Booty, Maggie K. Richardson, Dylan B. Jackson, Delvon T. Mattingly

Sociology Faculty Publications

Objective: The rise in adolescent handgun carriage over the past decade represents a significant public health concern. Using nationally representative data, this study examines risk factors associated with handgun carriage among U.S. adolescents.

Methods: We used data on adolescents aged 12–17 years from the 2021 and 2022 National Survey on Drug Use and Health ( n = 20,869), with past-year handgun carriage defined as a binary variable. Logistic regression estimated odds ratios (ORs) and 95% confidence intervals (CIs) to determine factors associated with handgun carriage across adolescent age groups (12–13 years, 14–15 years, 16–17 years).

Results: The average prevalence of …

Evaluation And Design Of A Footing Hybrid Connection For Innovative Hollow-Core Fiber-Reinforced Polymer–Concrete–Steel Composite Columns, Mohanad M. Abdulazeez, Mohamed A. Elgawady

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

To support the advancement of accelerated bridge construction in high-seismic regions, this study investigates a novel prefabricated column-to-footing connection designed for improved resiliency, constructability, and cost efficiency. The socket connection utilizes hollow-core fiber-reinforced polymer–concrete–steel (HC-FCS) columns with embedded corrugated steel pipes (CSPs). The composite HC-FCS column consists of a concrete shell sandwiched between an outer fiber-reinforced polymer tube and an inner steel tube. The inner steel tube is embedded into the footing connection of the HC-FCS column. The same authors tested the innovative socket connection on a large HC-FCS column under seismic loads, showing high ductility, strong moment and drift …

Dcmm-Transformer: Degree-Corrected Mixed-Membership Attention For Medical Imaging, Huimin Cheng, Xiaowei Yu, Shushan Wu, Luyang Fang, Chao Cao, Jing Zhang, Tianming Liu, Dajiang Zhu, Wenxuan Zhong, Ping Ma

Computer Science Faculty Research & Creative Works

Medical images exhibit latent anatomical groupings, such as organs, tissues, and pathological regions, that standard Vision Transformers (ViTs) fail to exploit. While recent work like SBM-Transformer attempts to incorporate such structures through stochastic binary masking, they suffer from non-differentiability, training instability, and the inability to model complex community structure. We present DCMM-Transformer, a novel ViT architecture for medical image analysis that incorporates a Degree-Corrected Mixed-Membership (DCMM) model as an additive bias in self-attention. Unlike prior approaches that rely on multiplicative masking and binary sampling, our method introduces community structure and degree heterogeneity in a fully differentiable and interpretable manner. Comprehensive …

Characterization Of The Human Thnatomicrobiome By Decomposition Stage Through Bioinformatic And Meta Data Analysis, Ashton C. Laughlin

Biology Theses

Estimating the postmortem interval (PMI) is one of the most crucial factors in forensic death investigations. Recent advances in forensic microbiology have led to increased interest in using the study of the human postmortem microbiome, or “thanatomicrobiome,” to improve PMI estimates. In addition to current PMI estimation techniques, microbial community succession could serve as a valuable tool in estimating PMI. Further research is needed to develop a comprehensive understanding of the human postmortem microbiome. The purpose of this study is to contribute to the expansion of this tool by reviewing the current literature and analyzing previously published data using the …

Adversarial Robustness In Biomedical Time-Series Models, Rohan Tiwari

Bioengineering Theses

This study investigates adversarial vulnerabilities in deep learning models for biomedical time-series classification across two clinically important modalities: electrocardiography (ECG) and electroencephalography (EEG). Using the MIT-BIH Arrhythmia and CHB-MIT seizure datasets, I evaluate time-domain attacks (FGSM, PGD), Fourier-domain constrained attacks, and learned spectral perturbations designed to reveal modality-specific sensitivity patterns. Across both tasks, a consistent trend emerges low-frequency components (0–5 Hz) constitute a dominant axis of adversarial vulnerability, with perturbations in this range producing the steepest degradation in classification performance. In ECG models, protecting the physiologically relevant QRS band (5–20 Hz) significantly improves robustness, whereas EEG models remain highly sensitive …

Intermittent Versus Continuous Reinforcement: Which Is More Effective For Skill Acquisition In Children With Adhd Using Precision Teaching?, Samantha Pulling

Masters Theses

Children with Attention Deficit Hyperactivity Disorder (ADHD) can experience challenges learning academic skills, possibly because of altered reinforcement and learning processes. Reinforcement is commonly used to support learning and adaptive behavior; however, research examining continuous and intermittent reinforcement schedules for children with ADHD has produced inconsistent findings. Precision Teaching (PT) is a fluency-based, data-driven instructional approach that emphasizes rate and celeration of behavior and has been shown to effectively support academic learning for individuals with ADHD. This study compared the effects of a continuous reinforcement schedule with a small reinforcer and an intermittent reinforcement schedule with a larger reinforcer on …

Risk Factors Of Child Sex Trafficking: A Gender-Based Scoping Review In The U.S. And Cross-Border Contexts, Peyton Forbes

Social Work Theses

Child sex trafficking is a major public health issue affecting the youth population of the United States and internationally. This scoping review examines risk factors on multiple levels including individual, family, community, and macro and digital contexts. A systematic search of databases identified 32 studies meeting inclusion criteria. Findings suggest that individual-level risk includes cumulative exposure to violence and trauma, substance use, mental health and behavioral problems, child welfare and justice involvement, runaway behavior, educational disruption, limited social support, and intersection demographic vulnerabilities (e.g., gender, sexuality, race/ethnicity, disability). Family‑level risk reflects unstable or unsafe home environments characterized by substance use, …

Economic Development And The Environment, Kelsey Jack, Nicholas Ryan

Discussion Papers

Economic development relies on and transforms the environment. The transformation is evident in the poor environmental quality in many developing countries. For example, air quality in Southeast Asia is three times worse than in the United States, in sub-Saharan Africa four times worse and in South Asia more than six times worse. We model how environmental quality affects health, productivity and well-being and how individuals privately adapt to environmental hazards. We also model how collective action and formal regulation contribute to environmental quality. We draw three main findings from a review of empirical research on these mechanisms. First, individual adaptation …

Skipping The Factory: Service-Led Growth And Structural Transformation In The Developing World, Michael Peters, Youdon Zhang, Fabrizio Zilibotti

Discussion Papers

In today’s developing world, many economies appear to bypass industrialization and transition directly from agriculture to services. The largest rise in service employment has occurred in non-tradable consumer services, such as retail and hospitality, especially in urban areas, where many cities resemble consumer hubs built around local demand. These patterns of growth raise fundamental questions: Can service-led growth sustain improvements in living standards over time? Is service-led growth inherently biased toward affluent urban consumers? What role should policy play? To address these questions, we propose a parsimonious general equilibrium framework that incorporates non-homothetic preferences and locally non-tradable consumer services in …

Rethinking Transnational Adjudication: The Normative Foundations Of Institutional Design, Sanctions-Related Arbitration Frameworks, And Digital Recognition Systems, Avaskhan Asanaliyev

SJD Dissertations

This dissertation examines how emerging judicial and dispute resolution architectures can sustain cross-border commerce, investment, and enforcement in the post-Soviet space and beyond, at a time of institutional fragility, geopolitical tension, and rapid digitalization. Drawing on the experience of Kazakhstan, Russia, Ukraine, and key global hubs, it argues that institutional innovation in courts, arbitration, and enforcement mechanisms is central to rebuilding credible governance frameworks for international business. It does so through three interconnected studies that together explore the evolution of modern adjudication: first, through the transplantation of a common law judiciary model within a civil law state; second, through the …

The Role Of Soil In Historical Warfare: A Review, Gian Franco Capra, T. A.R. Nogueira, Cassio Hamilton Abreu-Junior, Arun Dilipkumar Jani, Rafael Barroca Silva, Eleonora Grilli, Alessandro Auzzas, Antonio Ganga

Biology, Agriculture and Chemistry Faculty Publications and Presentations

Soil has played a fundamental yet undervalued role in shaping the fate of historical warfare. While the effects of war on the soil environment have been thoroughly investigated, the impact of soil on military strategies and battle outcomes remains poorly understood. This review aims to: i) explore the multifaceted role of soil in warfare, focusing on its impact on several aspects (mobility, fortifications, camouflage, health, geopolitical strategy, etc.); ii) identify which soil types were usually most associated with conflicts, and iii) how soil features influenced military decision-making. A dataset of over 17,000 recorded battles (1468 BCE–2003) was …

Pork, Parties, And Power: Money Politics In Japanese Political Parties, Maya Maranto

HMC Senior Theses

This thesis examines the proposition that the LDP utilizes money politics more than opposition parties in Japan, which could explain why the LDP has remained largely dominant since 1955. Focusing on the House of Representatives elections in 2017, 2021, and 2024, I analyze eight case studies, examine the University of Tokyo-Asahi Shimbun Elite Candidate Survey covering over 90 percent of candidates, and quantitatively analyze party manifestos. I operationalize money politics as reliance on support organizations, support for infrastructure and agriculture, forestry, and fisheries, and support for regional funding. I find that, all measures taken together, the LDP remains the most …

Blurred Lines: Did Booker Change Federal Sentencing Outcomes?, Hugh Mundy

UIC Law Open Access Faculty Scholarship

No abstract provided.

American Loopholes: What Are They, And How Do We Close Them?, Tanner L. Martin

Wyoming Law Review

This Comment examines the existence and impact of alleged loopholes within American gun control laws and explores how these gaps may affect Constitutional rights, legal enforcement, and public safety. In addition to identifying trends in American gun ownership, including patterns of purchasing, possession, and regulatory compliance, this Comment analyzes the current legal standards that determine who is disqualified from owning or possessing a firearm under federal law. These categories include individuals with certain criminal convictions, domestic violence restrictions, or mental health adjudications, and how those legal standards are applied in practice.

Beyond the legal framework, this Comment also considers the …

Fear, Delay, And Preventable Death: Rethinking Wyoming's Legislative Framework To Reduce Barriers In Overdose Emergency Reporting, Shoshana Sangros

Wyoming Law Review

This Comment asks whether Wyoming’s current immunity framework for reporting overdoses truly reduces delays in emergency treatment when distance, weather, and limited emergency medical service (EMS) capacity already regularly extend response times. It proposes that by amending two Wyoming statutes and funding statewide education, the goal of reducing barriers to calling 9-1-1 to report overdoses can be better achieved, and residents better protected. To support these proposed changes, Part II provides a concise account of relevant Wyoming statutory protections. Part III proposes specific amendments that would address the on-the-ground challenges of the Wyoming emergency response system. These adjustments will utilize …

Medications For Opioid Use Disorder In Correctional Facilities: A 2022 Cross-Sectional Survey Of Health Care Staff, Claire Wolfe, Sabrina Gaiazov, Dr. Pamela Valera, Will Mullen, Ross Macdonald, Christian Heidbreder

School of Social Work Faculty Publications

A national, anonymous, online survey was administered inviting 3,161 correctional health professionals to examine the associations between facility characteristics and the availability of medications for opioid use disorder (MOUD) in jails and prisons. Responses from 268 participants representing 212 correctional facilities were analyzed. We used multivariate logistic regression to identify associated facility characteristics, and open-ended responses were analyzed using content analysis. Facilities in the Western United States had higher odds of providing MOUD compared with those in the Midwest (adjusted odds ratio [AOR] = 3.67, 95% confidence interval [CI]: 1.28–10.99). Jails had higher odds of offering MOUD than prisons (AOR …

Kinase Signaling In Liver Disease Via Clinical-Trial-On-A-Pamchip: A Distinctive Methodology For Drug Mechanisms And Personalized Medicine, Zachary A. Kipp, Evelyn A. Bates, Genesee J. Martinez, Wang-Hsin Lee, Sally N. Pauss, Terry D. Hinds, Jr.

Pharmacology and Nutritional Sciences Faculty Publications

The utilization of extensive datasets, such as those generated by DNA or RNA sequencing, has become a central focus in drug discovery and personalized medicine (PerMed). Nonetheless, these datasets are constrained by the absence of protein-functionality testing, which affects physiological responses. In this study, we employed PamGene PamStation technology to quantify protein function by kinase activity across more than 500 signaling pathways from patients with hepatocellular carcinoma (HCC). Using proteins derived from nine patients and five human HCC cell lines for drug discovery and the clinical trial-on-a-chip approach, we developed comprehensive PerMed scores from the PamStation data to differentiate individual …

“If You Can Do This Job, You Can Do Anything”: An Exploration Of The Lived Experiences Of Early Career Social Workers Engaged With People Living With Hiv/Aids, John J. Edwards

Bryn Mawr College Dissertations and Theses

The HIV/AIDS epidemic, now in its fifth decade, is one of the most consequential health, social, scientific, and political challenges of the modern era. Since its emergence, social work has played a critical role in service provision and advocacy on behalf of people living with HIV/AIDS (PLWHA). Tremendous biomedical advancements over the years have fundamentally transformed HIV from an invariably fatal illness to a chronic and manageable condition. As the profile of HIV has changed over time, less is known about the contemporary experiences of social workers engaged with PLWHA. To address this gap, semi-structured interviews were conducted with early …

Modeling “Abnormal” Ovulatory Dynamics: Enzymes, Insulin, And The Impact Of Stress, Savannah E. Williams

Bryn Mawr College Dissertations and Theses

This work focuses on modeling the impact of stress on ovulatory dynamics. We develop a mathematical model of endocrine processes including gonadotropin-releasing hormone, kisspeptin signaling, and the ovulatory cycle. Integral to our model development, we define ovulatory criteria, conduct an extensive global sensitivity analysis, and fit parameters to clinical hormone data throughout the ovulatory cycle. We then incorporate four biological pathways through which stress may interact with the ovulatory cycle – increased aromatase activity, hyperinsulinemia, suppression of luteinizing hormone (LH), and the influence of cortisol on kisspeptin signaling. High levels of simulated chronic stress cause significant disruption of the ovulatory …

Signaling Scaffold Shoc2 Regulates Lymphangiogenesis By Suppressing Mtorc1-Mediated Ifn Responses, Patricia Wilson, Vishakha Vishwakarma, Rebecca Norcross, Kashmira Khaire, Van N. Pham, Brant M. Weinstein, Hyun Min Jung, Emilia Galperin

Molecular and Cellular Biochemistry Faculty Publications

An interplay of growth factors and signaling pathways governs the development and maintenance of lymphatic vasculature, ensuring proper fluid homeostasis and immune function. Disruption of these regulatory mechanisms can lead to congenital lymphatic disorders and contribute to various pathological conditions. However, the mechanisms underlying the molecular regulation of these processes remain elusive. Here, we reveal a critical and previously unappreciated role for the signaling scaffold protein Shoc2 in lymphangiogenesis. We demonstrate that loss of Shoc2 results in near-complete loss of lymphatic vasculature in vivo and senescence of lymphatic endothelial cells in vitro. Mechanistically, Shoc2 is required for balancing signaling through …

Current And Emerging Therapeutic Strategies For The Treatment Of Duchenne Muscular Dystrophy, Miguel A. Lopez Perez, Noah L. Weisleder

Molecular and Cellular Biochemistry Faculty Publications

Background/Objectives: Duchenne muscular dystrophy (DMD) is a fatal, progressive neuromuscular disorder caused by mutations in the dystrophin gene, leading to the absence of functional dystrophin protein. As the largest gene in the human genome, the DMD locus is highly susceptible to mutations, contributing to a prevalence of approximately 1 in 3800–6300 live male births worldwide. This review aims to provide a comprehensive and critical synthesis of current and emerging therapeutic strategies for DMD.

Methods: We conducted a narrative review of the literature, integrating findings from clinical trials, regulatory approvals, and preclinical studies. We categorized therapeutic approaches into mutation-agnostic and mutation-specific …