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Single Intratympanic Injection Of Proprietary Brain-Derived Neurotrophic Factor (Oto-413) In Subjects With Speech-In-Noise Hearing Impairment: A Randomized, Dose Escalating, Double-Blind, Placebo-Controlled Phase 1/2 Study, Alan C. Foster, Jeffery J. Anderson, David R. Moore, Morgan Oktela Fuentes, Yiwei Wang, Peter G. Volsky, K. Paul Boyev, Victoria A. Sanchez

Department of Otolaryngology (ENT) Faculty Publications

Purpose

To evaluate the safety and tolerability and exploratory efficacy of OTO-413, an intratympanic-administered, sustained release formulation of brain-derived neurotrophic factor (BDNF) in a thermoreversible gel, in participants with speech-in-noise hearing difficulties.

Methods

This was a single dose, dose-ascending, randomized, double-blind, Placebo-controlled Phase 1/2 study conducted at 7 enrolling clinical sites in the U.S. 110 participants (56% female) enrolled had self-reported speech-in-noise (SIN) difficulties that were confirmed by a SIN test and were randomized to OTO-413 or Placebo. OTO-413 dose range was escalated from 0.01 mg to 1.5 mg within 7 Cohorts. Safety evaluations included monitoring for treatment-emergent adverse events, …

The Influence Of Defendant Mental Illness Characteristics On Prosecutorial Decision Making, Claire Elise Martin

Theses

As most criminal cases are now resolved via plea-bargaining, research on legal decision making has extended beyond the jury to evaluate judges, defense attorneys, and prosecutors. Although legal actors are obliged to remain objective and dispassionate, extralegal factors regarding defendant characteristics (e.g., age, gender, race/ethnicity, socioeconomic class) can influence case outcomes. Extant research on the effect of defendant mental health status and defendant demeanor on sentencing outcomes in court hearings is limited. Therefore, the present experiment solicited 134 prosecutors in a vignette study designed to assess how extralegal characteristics, specifically those related to mental illness, may affect the punitiveness of …

Modeling And Identification Of Thermal Interactions In Lithium-Ion Battery Modules, Saima Alam

Theses

The recent development of lithium-ion battery technology has fueled its adoption in electric vehicles (EVs) as the primary power source due to its high energy and power density. However, the high energy density comes at the cost of higher safety requirements. To ensure the lithium-ion battery pack's operational safety, performance optimization, and longevity, a Battery Management System (BMS), an electronic controller, is employed. Recent reports of battery pack overheating, fire, and explosion in EVs expose the limitations of the BMS in detecting the abnormalities and preventing them from propagating to other cells. To address these limitations, in the first part …

Prepared Food V. Jaber, E.D. Wisconsin

Historical and Topical Legal Documents

No abstract provided.

Judge V. Academia, Northern District Of California

Historical and Topical Legal Documents

No abstract provided.

Vedros V. The Sterling Group Of The Twin Tiers, Western District Of Pennsylvania

Historical and Topical Legal Documents

No abstract provided.

Netchoice V. Wilson, District Of South Carolina

Historical and Topical Legal Documents

No abstract provided.

An Introduction For Nursing Research: An Open Educational Resource For The Undergraduate Nursing Student, Ellen Benjamin

OER Textbooks

The purpose of this text is not to prepare you to independently conduct research, but to help you become an informed and critical consumer of research. The ability to systematically evaluate the strengths, limitations, and applicability of research findings is known as critical appraisal. Critical appraisal is an expected competency of baccalaureate-prepared nurses [5] and requires a foundational understanding of research principles and methods. This book will introduce the research process, including common research methodologies, data collection and analysis approaches, ethical considerations, and strategies for translating research evidence into nursing practice.

Prevalence And Correlates Of Anxiety And Depression Symptoms Among Medical Students: The Role Of Student Debt Burden, Foroozan Afsharchi, Joshua F. Edwards, Kailash S. Ram, Jingru Huang, Valicia Hale, Ismail El Moudden

Department of Family and Community Medicine Faculty Publications

Background

This cross-sectional study examined whether anxiety and depression symptoms decrease as medical students progress through training (suggesting adjustment disorder) or persist (suggesting chronic conditions), while identifying associated risk factors, including student debt burden and treatment effectiveness.

Methods

We surveyed medical students (years 1-4) at VHS-ODU using a sociodemographic questionnaire and validated screening instruments (GAD-7 for anxiety and PHQ-9 for depression) via RedCap from September to November 2024.

Results

Among 126 students, Scores were higher in Years 2-3 than in Years 1 and 4, but differences by year were not significant (GAD-7 p=0.055; PHQ-9 p=0.352). Students with a prior mental-health …

Successful Use Of Chimeric Antigen Receptor T-Cell (Car-T) Therapy With Lisocabtagene Maraleucel In A Renal Transplant Recipient With Refractory/Relapsed Diffuse Large B-Cell Lymphoma (Dlbcl), Waqqas Tai, Fatima Chaudhry, Nesreen Shahrour, Jessica Thomas, Afoma Anyadibe, Anuoluwa Oyetoran, Swathi Gopishetty, Precious Idogun, Dilip Samarapungavan, Jassim H. Sarmad, Ishmael Jaiyesimi

Department of Medicine Faculty Publications

This case describes a 53-year-old male with end-stage renal disease who developed monomorphic post-transplant lymphoproliferative disorder (PTLD) in the form of diffuse large B-cell lymphoma (DLBCL) after kidney transplantation. Despite initial treatment with rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone (R-CHOP), the patient's disease progressed, and he was referred for chimeric antigen receptor (CAR) T-cell therapy with lisocabtagene maraleucel (liso-cel). Given his post-transplant status, his immunosuppressive agents (tacrolimus and mycophenolate) were held, and prednisone was tapered to 5 mg daily to maintain minimal baseline immunosuppression. After lymphodepleting chemotherapy and liso-cel infusion, the patient experienced no significant toxicities, including cytokine release syndrome (CRS) …

Comparison Of Fully Covered Self-Expandable Metal Biliary Stents With Or Without Anchoring Double-Pigtail Plastic Stents: A Systematic Review And Meta-Analysis, Samuel Tanner, Fadi Hawa, Alejandra Vargas, Priyata Dutta, Antonio Facciorusso, Jean M. Chalhoub, Jorge D. Machicado

Department of Medicine Faculty Publications

Background and AIMS

Fully covered self-expandable metal stents (FcSEMSs) have become the mainstay of treatment for a variety of biliary pathologies. However, FcSEMSs have been associated with a greater rate of stent migration than other types of stents. A technique of anchoring double-pigtail plastic stents (DPPSs) has been proposed to minimize migration of biliary FcSEMSs. Herein, we evaluated the efficacy of anchoring DPPSs among patients treated with biliary FcSEMSs.

Methods

We performed a systematic review using PubMed, EMBASE, and Web of Science from database inception through August 2023. Full-text articles comparing FcSEMSs with or without anchoring DPPSs were included. We …

Living With Water In Fields Landing & King Salmon: Community Knowledge Of Flooding And Adaptation Strategies In Coastal California, Kailin Sepp

Cal Poly Humboldt theses and projects

Known as “ground zero,” Humboldt Bay is among the most vulnerable areas to sea-level rise (SLR) due to geological and tectonic factors on the West Coast. While the land subsides, oceans rise, resulting in an area with one of the highest recorded rates of relative SLR on the West Coast. The residential communities of Fields Landing and King Salmon in South Humboldt Bay already experience regular coastal flooding. There is a need for better information and planning to understand the vulnerability to flooding/SLR and plan for adaptation. Typically, studies addressing flooding, such as vulnerability assessments and adaptation plans, are developed …

Bridging The Gap: A Systematic Review Of Cyber Conflict Forecasting Models And The Case For Ai-Driven Dynamic Frameworks, Salim Arfaoui, Youssef Harrath, Omar El-Gayar

Research & Publications

Cyber conflict forecasting remains constrained by static models that overlook the integration of geopolitical context with technical indicators. This systematic literature review examines 58 studies (2010–2025) using PRISMA guidelines and an Input-Process-Output framework to classify approaches and identify key gaps. Quantitative methods dominate (67%), yet only 14% incorporate geopolitical variables, despite the political nature of cyber conflict. Major limitations include adversarial adaptation blindness (85% assume static behavior), coarse temporal granularity (72% use daily+ intervals), lack of uncertainty quantification (75%), and minimal modeling of cross-domain escalation (92% cyber-only focus). Strategic forecasting is rare, with just 14% providing long-term insights and 16% …

Autotheme: A Multi-Agent Framework For Inductive Thematic Analysis With Llms, Abdullah Wahbeh, Omar El-Gayar, Mohammad Al-Ramahi, Tareq Nasralah, Ahmed Elnoshokaty

Research & Publications

Thematic analysis is a qualitative research method used to identify and interpret patterns in textual data. However, it can be time-consuming and challenging to replicate. While recent advancements in large language models (LLMs) and generative AI have enhanced thematic analysis, existing methods often rely on prompt-based interactions and require significant human intervention. This paper introduces an agentic AI framework comprising autonomous, goal-directed agents powered by LLMs to perform inductive thematic analysis with minimal human input. We evaluate the framework using a dataset from a Cognitive Behavioral Therapy (CBT) mobile app and compare the results with those from Latent Dirichlet Allocation …

Multimodal Late-Fusion Of Radiomics, Clinical Data, And Demographics Enhances Personalized Survival Prediction In Nsclc, Zarindokht Helforoush, Mohamed Jaber, Nezamoddin N. Kachouie

Mathematics and System Engineering Faculty Publications

Backgrounds/Objectives: Non-small cell lung cancer (NSCLC) exhibits substantial prognostic heterogeneity that is not fully captured by conventional anatomical staging, highlighting the need for individualized risk assessment. Radiomics enables non-invasive characterization of tumor phenotype, yet high dimensionality and inter-feature correlations often limit model stability and interpretability. Methods: To address these challenges, we developed a multimodal late-fusion framework integrating radiomic, clinical, and demographic information to predict patient-specific absolute risk in the Lung1 cohort (N = 398). Radomic features (N = 107) were extracted from primary tumor volumes and refined using a Group Lasso–penalized Cox model, preserving biological coherence and producing a parsimonious …

Tennessee Archivist 45, No. 1, Society Of Tennessee Archivists

Tennessee Archivist newsletters

Winter 2026 issue of the Tennessee Archivist, a newsletter produced by the Society of Tennessee Archivists.

The Effects Of Expectancies And Attention To Placebo Relevant Sensations On The Open-Label Placebo Response, Miranda Connelly

Cal Poly Humboldt theses and projects

Placebo analgesia has shown promise in treating pain, but practitioners are reluctant to prescribe deceptive placebos. Open-label, or honestly prescribed placebos, offer an ethical alternative. Open-label placebos seem to work largely through experimenter-manipulated expectancy, as well as social/environmental factors. Additionally, verbally guided attention to relevant placebo sensations might bolster pain relief. In the present study, expectancy and attention were experimentally manipulated within a 2 (expectancy: high/low) x 2 (attention: high/low) between-subjects design with a no-treatment comparison group. Pain was experimentally induced in all five experimental groups using the well-established cold pressor task. The primary dependent variables were pain tolerance and …

Examining The Physiological Stress-Reducing Effects Of Virtual Nature Exposure And Slow Breathing, Jesse Benefiel

Cal Poly Humboldt theses and projects

In a time of excess stress, it is essential to examine accessible stress-reduction methods. Research has demonstrated that virtual nature exposure and slow breathing can independently reduce stress, but the literature is lacking with regard to their combined effects. The present study aimed to replicate independent effects of breathing and nature on stress and to test for potential effects, including whether their combination would produce an interaction effect. Using a 2 Environment (Natural v. Control) by 2 Breathing (Slow v. Normal) between-subjects design, 63 participants completed a modified color-word Stroop task to induce stress and were then exposed to either …

The Effect Of Automated Self-Monitoring On The Behavior Of Individuals Diagnosed With Pre-Diabetes Or Type 2 Diabetes, Leti Phillips Armenta

Cal Poly Humboldt theses and projects

Type 2 diabetes (T2D) and prediabetes affect millions of individuals in the United States and require effective self-management strategies to reduce glucose variability and improve health outcomes. This study evaluated the effects of automated self-monitoring using the Dexcom G7 continuous glucose monitor (CGM) on glucose management and health-related behaviors among adults diagnosed with prediabetes or at risk for T2D. A repeated-measures design was used to asses’ participants across two distinct 10-day periods. Data included CGM glucose readings, self-report questionnaires, and social validity measures. Results indicated that participants demonstrated reduced glucose variability, fewer prolonged glucose spikes, and increased engagement in health-related …

Land Cover Classification Using Optimized Imagery Resolution And Machine Learning Algorithms For A Long-Term Monitoring And Restoration Project, Jessica R. Suoja

Cal Poly Humboldt theses and projects

Ecosystem services and functions are prone to water resource exploitation resulting in cascading effects that include decrease of biodiversity and loss of riparian vegetation, a keystone habitat in desert riparian ecosystems. Mono Lake is a prime example of overexploitation of water resources leading to legal action and eventually a legally mandated long-term monitoring and restoration project. Monitoring and restoration projects can benefit from techniques such as remote sensing and machine learning algorithms to generate accurate land cover classification maps for calculating land cover change over time. However, the spatial resolution of remote sensing imagery and the machine learning algorithms chosen …

Reclaiming Presence: An Anthropological Study Of Digital Disconnection And Meaning-Making, Leslie De Paz

Cal Poly Humboldt theses and projects

Human attention is increasingly at risk in an unregulated digital ecosystem where overconsumption shapes neurological function, social interaction, and the ways people make meaning of everyday life. Dominant discourse around digital overuse tends to medicalize the problem, framing it as individual addiction or clinical dysfunction. In this thesis, I argue that such framing obscures what a cultural phenomenon is fundamentally, one in which people are actively questioning their relationship with technology, building awareness, and developing practices that help them slow down and reclaim agency within algorithmically mediated environments. This study draws on 22 semi-structured interviews with Gen Z and millennial …

Supporting Risky Outdoor Play Through Professional Development: A Quasi-Experimental Study Of Tk–6 Educators’ Attitudes, Justin Ross Burrill

Cal Poly Humboldt theses and projects

Children’s opportunities for active outdoor risky play have declined in many educational settings, despite evidence that manageable risk supports physical activity, self-regulation, confidence, resilience, and social participation. Educator attitudes and school culture may play an important role in determining whether children are offered developmentally appropriate opportunities for challenge, exploration, and autonomy. This quasi-experimental, single-group pretest-posttest study examined whether participation in a single-session professional development workshop was associated with changes in educators’ tolerance of risk in children’s play. Thirty educators attended a workshop focused on risky play, hazard-risk differentiation, inclusion of children with disabilities, loose-parts play, environmental affordances, and practitioner-informed implementation …

The Spatial Relationship Between The Residents Of Buttonwillow, Ca And The Carbon Capture And Storage Project, Carbon Terravault, Daniell Dorado

Cal Poly Humboldt theses and projects

Carbon capture, utilization and storage (CCUS) is one necessary component in California’s strategy in meeting its carbon neutrality goals. CCUS serves as an important piece to reduce greenhouse gas emissions where other sequestration methods are not yet feasible for certain sectors like electricity generation, cement production and refineries. At the same time, the impacts of industrial projects disproportionately impact underserved communities, and there is a need for more equitable community engagement practices. The state has had an increase in CCUS projects, and several are or will be in Kern County, which has often been a leader in the oil and …

An Association Test For Ordinal Outcomes In Clustered Data With Informative Cluster Size, Hasika K. Wickrama Senevirathne, Sandipan Dutta

Mathematics & Statistics Faculty Publications

In cluster-correlated data, the number of observations in a cluster can be associated with the outcome from that cluster. This phenomenon is known as informative cluster size which can occur in cluster-randomized clinical trial data. Several studies have found that ignoring the issue of informative cluster size can produce biased results in the analysis of clustered data. Most of the existing methods for addressing informative cluster size are suited to continuous outcomes. However, ordinal outcomes and covariates are often encountered in clustered data obtained from large clinical studies. The existing methods for ordinal association testing in clustered data can produce …

Real-World Anti-Amyloid Therapy Beyond Traditional Symptomatic Populations: A Longitudinal Case Series, Jayoung Han, Yuan Fang, Darlingtina Esiaka, Olufunmilola Abraham

Mathematics & Statistics Faculty Publications

Introduction: Anti-amyloid monoclonal antibodies are approved as disease-modifying therapies for early Alzheimer’s disease (AD), but real-world evidence remains limited, particularly among individuals treated during preclinical or minimally symptomatic stages. This study characterized clinical and biomarker trajectories among anti-amyloid therapy recipients across disease stages.

Method: We conducted a longitudinal retrospective case series of three biomarker-positive individuals from the Alzheimer’s Disease Neuroimaging Initiative who received lecanemab or donanemab. Clinical, cognitive, cerebrospinal fluid, plasma biomarker, and amyloid PET data were examined.

Results: In all three cases, most of the observation period preceded anti-amyloid therapy initiation. Clinical trajectories varied by biomarker profile and treatment …

Dextromethorphan And Trace Level Detections Of Dextrorphan In Post-Race Urine Samples – A Case Report And Analysis, Kimberly Brewer, Justin C. Holmes, Clara Fenger, Abelardo Morales-Briceño, Andreas F. Lehner, George A. Maylin, Robert Holland, Levent Dirikolu, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Dextrorphan is a Phase I equine metabolite of dextromethorphan, a widely used anti-tussive / cough suppressant medication marketed and available in numerous over-the-counter formulations in the United States. Dextromethorphan is an Association of Racing Commissioners International (ARCI) drug class 4 penalty class B substance and a Horseracing Integrity and Welfare Authority (HIWU) CONTROLLED S7 B substance and is regulated as such in horse racing. In horses, dextromethorphan is metabolized to its Phase I metabolite, dextrorphan, which is next glucuronidated and the resultant dextrorphan-glucuronide conjugate then excreted at remarkably high concentrations in equine urine. Dextrorphan is therefore at times identified in …

Increasing Uptake Of Diabetes Self-Management Education And Support (Dsmes) In Rural Kentucky Primary Care Clinics, Mary E. Lacy, Jessica Elliott, Vance Drakeford, Laura Wright, Brent Mckune, Key C. Douthitt, Aaron J. Kruse-Diehr, James W. Keck

Epidemiology and Environmental Health Faculty Publications

Background: Diabetes self-management education and support (DSMES) is an evidence-based intervention that improves outcomes for people with diabetes, but uptake is <10%. We conducted a pilot pragmatic trial to increase DSMES in rural primary care clinics that integrated health information technology with a quality improvement (QI) learning collaborative. Methods: Two healthcare systems from rural Kentucky participated in the study. Within each system, 2 clinics received the intervention and 1 clinic served as a control (N = 6 clinics). Each intervention clinic identified a QI team (5-6 individuals) who participated in a 9-month QI learning collaborative followed by 5 months of follow-up. Our primary outcome was DSMES referrals; secondary outcomes were DSMES attendance and percentage with A1c >9%. Results: The 6 study clinics served 1,803 patients with diabetes; n = 1083 (60.1%) from 4 intervention clinics and n = 720 (39.9%) from 2 control clinics. DSMES referrals significantly increased in the intervention clinics compared to the control clinics (31.7% vs 0.1%, P < .001) and continued to increase throughout 5-month follow-up (40.0% vs 0.1%, P < .001). Conclusions: A structured QI intervention can significantly increase DSMES referral rates in primary care clinics. Findings highlight the potential of systems-level approaches to address persistent gaps in diabetes care delivery in rural settings. Clinical Trial Registry: Using Practice Facilitation and Operationalizing Referral Information Technology to Increase DSMES Utilization (Clinicaltrials.gov registration number no. NCT05472142). Clinicaltrials.gov URL (https://clinicaltrials.gov/study/NCT05472142).

The Association Between Human Papillomavirus Type 16 E6 Seroprevalence And Degrees Of Anal Disease Among Men With Hiv, Krystle A.Lang Kuhs, Christopher Otieno, Staci Sudenga, Tim Waterboer, Weiqun Tong, Dorothy Wiley, Jay H. Bream, Steven Wolinsky, Jeremy Martinson, Gypsyamber D’Souza

Epidemiology and Environmental Health Faculty Publications

Introduction: Human papillomavirus type 16 (HPV16) E6 antibodies may be an early biomarker of anal cancer. We cross-sectionally evaluated when in the course of anal disease, HPV16 antibodies are induced. Methods: A nested case-control study of 846 men who have sex with men (MSM) was conducted within a prospective study of men with and without HIV. Cases of anal HPV16 (N=262), biopsy-confirmed high-grade squamous intraepithelial lesion (HSIL;N=140), and anal cancer (N=21) were individually matched to controls (N=423) on HIV status, study-participation duration, and age. Serum samples closest to diagnosis underwent HPV serologic testing; prediagnostic serial samples were tested for anal …

A Comprehensive Analysis Of Jurisdiction-Specific Laws Related To Scheduling Or Required Prescription Drug Monitoring Of Gabapentin In The United States, 2016–2024, Katherine Gora Combs, Rachel Vickers-Smith, Collin Stewart, Daniel Wacker, Juan M Hincapie-Castillo

Epidemiology and Environmental Health Faculty Publications

Gabapentin prescription use has increased across the United States since the late 2000s. Concerns of potential misuse and growing overdose involvement have led to the passage of jurisdiction-specific policies targeting gabapentin prescribing; however, the current legal landscape of these policies is not well documented or understood. We conducted a comprehensive, longitudinal analysis of policies related to scheduling or required prescription drug monitoring of gabapentin across 51 jurisdictions in the United States from January 2016 through December 2024. Across the study period, 25 jurisdictions (49 %) enacted policies related to gabapentin scheduling or required prescription reporting. Eight (16 %) jurisdictions classified …

Optimizing Control Definitions In Opioid Use Disorder Genetic Research Using Electronic Health Records, Maria Niarchou, Ellen L Tsai, Mariela V Jennings, Annika Faucon, Hyunjoon Lee, Kritika Singh, Justin D Tubbs, Panos Roussos, Tian Ge, Richard C Crist, Rachel Vickers-Smith, Howard Edenberg, Amy Moore, Bradley T Webb, Eric O Johnson, Rachel L Kember, Jordan W Smoller, Lea K Davis, Brandon J Coombes, Georgios Voloudakis, David Burstein, Travis T Mallard, Vanessa Troiani, Sandra Sanchez-Roige

Epidemiology and Environmental Health Faculty Publications

Amidst the opioid crisis, understanding the genetic basis of opioid use disorder (OUD) is crucial for identifying biological mechanisms and intervention points. However, genome-wide association studies (GWASs) have been hampered by inadequate sample sizes and often the use of control populations not assessed for prior opioid exposure. Because opioid exposure is a prerequisite for the development of OUD, consideration of exposure history in controls is important. Electronic health record data (EHR) paired with genomic information allow a broader sampling of patients with OUD and exposed controls. We leveraged data across two healthcare systems to evaluate the impact of using controls …