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Articles 40621 - 40650 of 1791773
Full-Text Articles in Entire DC Network
Celebration Of Faculty Scholarship 2025, Olin Library
Celebration Of Faculty Scholarship 2025, Olin Library
Celebration of Faculty Scholarship
No abstract provided.
Genomic Surveillance: Your Dna Is Not Neutral, You Don’T Even Own It., Uri Kim
Genomic Surveillance: Your Dna Is Not Neutral, You Don’T Even Own It., Uri Kim
Mitchell Hamline Law Journal of Public Policy and Practice
No abstract provided.
90-Day Consulting Engagement Grounded In Authentic And Servant Leadership Approaches–Building Capacity For Small Business, Michon Hicks
90-Day Consulting Engagement Grounded In Authentic And Servant Leadership Approaches–Building Capacity For Small Business, Michon Hicks
Doctor of Strategic Leadership (DSL) Capstone Abstracts
This doctoral capstone project examined a 90-day consulting engagement designed to strengthen organizational capacity in a small, M/WBE-certified professional services firm operating in a government contracting environment. Grounded in authentic and servant leadership frameworks, the engagement used a structured 30-60-90-day intervention model to assess leadership alignment, administrative infrastructure, human resources capacity, data management practices, and marketing readiness. The project employed an organizational health check-up approach to diagnose systemic gaps, co-create solutions with organizational leadership, and implement practical tools to improve operational consistency, compliance readiness, and leadership effectiveness. Outcomes of the engagement included improved leadership alignment, standardized administrative and operational workflows, …
Chronic Dislocations And Pain In A College Athlete, Rachel Joseph, Trina Walker, University Of Wisconsin - Madison, Rebecca Kronk, Karen J. Whitt, Deborah O. Himes
Chronic Dislocations And Pain In A College Athlete, Rachel Joseph, Trina Walker, University Of Wisconsin - Madison, Rebecca Kronk, Karen J. Whitt, Deborah O. Himes
Faculty Publications and Presentations
This diagnostic case study describes an 18-year-old woman and competitive gymnast who presents with recurrent joint dislocations, chronic musculoskeletal pain, and dermatologic findings suggestive of a heritable connective tissue disorder. Early recognition of connective tissue disorders is essential for accurate diagnosis, genetic evaluation, injury prevention, and long-term management planning.
Grief Counseling Best Practices: A Delphi Study, Jillian M. Blueford, Megan J. Doughty Shaine, Elizabeth A. Doughty Horn, Marcela Kepic, Michael Kocet, Katie Kostohryz Dr., Sara Jean-Philippe, Jen R. Hartman
Grief Counseling Best Practices: A Delphi Study, Jillian M. Blueford, Megan J. Doughty Shaine, Elizabeth A. Doughty Horn, Marcela Kepic, Michael Kocet, Katie Kostohryz Dr., Sara Jean-Philippe, Jen R. Hartman
Adultspan Journal
This Delphi study identifies expert-informed best practices in grief counseling to address current gaps in counselor education. Findings present essential competencies—knowledge, skills, and awareness—to guide ethical, culturally responsive, and trauma-informed support for grieving individuals across diverse settings.
Digital Diplomacy And Activism: Sustaining Institutional Legacy Through State-Proxy Discursive Competition In The Aftermath Of The Usaid 2025 Suspension, Maryam Alaa Elprince
Digital Diplomacy And Activism: Sustaining Institutional Legacy Through State-Proxy Discursive Competition In The Aftermath Of The Usaid 2025 Suspension, Maryam Alaa Elprince
Capstone and Graduation Projects
This study examines how the 2025 suspension of the United States Agency for International Development (USAID) transformed the arena of U.S. foreign-aid diplomacy by eliminating the agency’s operational capacity and erasing its digital presence, thereby redistributing discursive authority across a fragmented communicative field. The research aims to determine how diplomacy adapts when a bilateral institution central to American soft power is dismantled through top-down decision, and whether discursive power exercised online can extend institutional relevance and legitimacy beyond structural collapse. Using an interpretivist qualitative design that combines digital-forensic reconstruction, document-based content analysis, and elite interviews with top ranking officials, the …
Trigger Warnings And A Pedagogy Of Trust, Morgan Read-Davidson
Trigger Warnings And A Pedagogy Of Trust, Morgan Read-Davidson
English Faculty Books and Book Chapters
"While the larger conversation about difficult content and trigger warnings is not new, the sudden need for urgently scheduled meetings with me did not begin until the COVID- 19 pandemic crisis and our move to remote instruction, and the subsequent adjustment back to the classroom. This seems to coincide with the increase of online and social media interaction during the pandemic, where the use of trigger warnings and content warnings on social media, particularly on Twitter, Instagram, and TikTok, have made the conversation far more visible. For students, this seems to have given them validation and confidence, as well as …
Introduction To Trigger Warnings: Teaching Through Trauma, Ian Barnard, Ryan Ashley Caldwell, Jada Patchigondla, Aneil Rallin, Morgan Read-Davidson, Ethan Trejo, Kristi M. Wilson
Introduction To Trigger Warnings: Teaching Through Trauma, Ian Barnard, Ryan Ashley Caldwell, Jada Patchigondla, Aneil Rallin, Morgan Read-Davidson, Ethan Trejo, Kristi M. Wilson
English Faculty Books and Book Chapters
"The individual histories of both trigger warnings and trauma have evolved rapidly in the overlapping wakes of COVID, mental health crises, attacks on educational institutions in the United States, climate apocalypse, evergrowing economic inequities, and, more promisingly, attempts at political redress and educational equity. At the same time, trigger warnings and trauma have become exponentially more intimately linked in the past few years. But however often the topic of trigger warnings provokes heated discussion, the appeals and alignments of the interlocutors equally as frequently defy neat political binaries. Critiques of trigger warnings come from all sides of the political and …
Impact Of Oxidative Stress On Mapk Signaling In Human Pancreatic Ductal Cell Line, Alexis Fink
Impact Of Oxidative Stress On Mapk Signaling In Human Pancreatic Ductal Cell Line, Alexis Fink
Theses
The main processes linked to diabetes (type 1 or type 2) and obesity are impaired insulin production and glucose intolerance. The imbalance between antioxidant defense systems and oxygen-reactive species are known as oxidative stress. Understanding oxidative stress and its substantial effects on diabetes is crucial. Reactive oxygen species (ROS) can activate mitogen-activated protein kinases (MAPKs). We hypothesize that altered MAPK phosphorylation and hence downstream signaling is associated with changes in oxidative stress in the human pancreatic duct epithelial cell line (H6C7). While H6C7 cells are often engineered to be cancerous precursors, the natural phenotype of these cells and their expression …
Exploring Interpenetrating Networks Derived From Compostable Polymers In Separations, Hailey Holshouser
Exploring Interpenetrating Networks Derived From Compostable Polymers In Separations, Hailey Holshouser
Theses
The increasing demand for environmentally friendly and sustainable water treatment technologies drives the development of membranes that work to balance mechanical durability, tunable selectivity, and long-term stability. In this exploratory work, an interpenetrating polymer network (IPN) membrane system composed of poly(butylene adipate-co-terephthalate) (PBAT) and poly(2-hydroxyethyl methacrylate) (pHEMA) was developed to provide a more compostable and compatible platform for advanced separation applications. While the compostability of the entire framework was not tested, the dominant presence of PBAT in the matrix makes the membrane intrinsically favorable for composting. Mechanochemical Ionic Electrochromic Generators (IEGens) were synthesized and incorporated into the PBAT backbone for …
Urban Effects On Cloud Formation, Boundary Layer Circulation, And Rainfall Over Miami, Aaron A. Serre
Urban Effects On Cloud Formation, Boundary Layer Circulation, And Rainfall Over Miami, Aaron A. Serre
Theses
The sensitivity of cloud and precipitation formation is expected to be enhanced over urban areas due to persistent sea-breeze forcing. This study combines surface observations, satellite data, and numerical modeling to investigate the impacts of urbanization in the Miami Metropolitan Region (MMR) on surface meteorology, cloud formation, and precipitation. Satellite observations reveal urban expansion of approximately 348 km², along the western boundary of the MMR. These areas also exhibit statistically significant increases in land surface and air temperatures. Geostationary satellite data show enhanced morning cloud formation over the MMR, while increasing rainfall and interannual variability in cloudiness are observed along …
Effects Of Energetic State On Male Mating Preferences In Poeciliid Fishes With Differing Mating Strategies, Katherine E. Taylor
Effects Of Energetic State On Male Mating Preferences In Poeciliid Fishes With Differing Mating Strategies, Katherine E. Taylor
Theses
Reproduction is energetically costly, making condition (i.e., energetic state) a potential factor in shaping reproductive behavior. However, its role in male mate choice remains largely unexplored. Here, we investigate condition-dependent effects on male mate choice in two species of Poeciliids: one coercive species (Gambusia affinis) and one courting species (Xiphophorus hellerii). Diet treatments were used to manipulate male and female conditions, and male preferences were assessed in dichotomous-choice tests using animated female stimuli. X. hellerii males showed a preference for high-condition females, whereas G. affinis males showed no overall net preference. Diet influenced preference in G. affinis, with high-fed males …
A Cost-Consequence Analysis Of The Children’S Administration Oxygenation Strategies Trial (Coast) In Severe Pneumonia, Orlagh U. Carroll, Richard Grieve, Sarah Kiguli, Peter Olupot-Olupot, Robert Opoka, Charles Engoru, Florence Alaroker, Abner Tagoola, Mainga Hamaluba, Eva Nabawanuka
A Cost-Consequence Analysis Of The Children’S Administration Oxygenation Strategies Trial (Coast) In Severe Pneumonia, Orlagh U. Carroll, Richard Grieve, Sarah Kiguli, Peter Olupot-Olupot, Robert Opoka, Charles Engoru, Florence Alaroker, Abner Tagoola, Mainga Hamaluba, Eva Nabawanuka
Paediatrics and Child Health, East Africa
Oxygen supplementation is a recommended treatment for children with severe pneumonia or hypoxaemia. The open, fractional-factorial Children’s Oxygen Administration Strategies Trial (COAST) recruited Kenyan and Ugandan children with severe pneumonia and hypoxaemia. Participants in the severe hypoxaemia stratum (SpO2 < 80%) were randomised to high-flow nasal therapy (HFNT) or low-flow oxygen (LFO), and in the hypoxaemia stratum (SpO2 80–91%) to HFNT, LFO or permissive hypoxaemia (ratio 1:1:2). The trial stopped early and there is ongoing uncertainty about the clinical benefits of the alternative strategies. There is a lack of evidence about the relative costs, of alternative oxygen delivery for critically-ill children in low- and middle- income countries. We used data from COAST to conduct a cost-consequence analysis …
2025 - 2026 Faculty Senate Annual Report, University Of South Carolina
2025 - 2026 Faculty Senate Annual Report, University Of South Carolina
Faculty Senate
The primary file includes the 2025 - 2026 Admissions Committee Report. Additional annual reports are attached.
Application Of The World Health Organization Disability Assessment Schedule 2.0 In Older Adults: A Narrative Review Of Current Evidence And Future Direction, Yuan-Chen Chang, Tsan-Hon Liou, Lien-Chieh Lin, Reuben Escorpizo, Shih-Wei Huang
Application Of The World Health Organization Disability Assessment Schedule 2.0 In Older Adults: A Narrative Review Of Current Evidence And Future Direction, Yuan-Chen Chang, Tsan-Hon Liou, Lien-Chieh Lin, Reuben Escorpizo, Shih-Wei Huang
Rehabilitation Practice and Science
The World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) is increasingly valued in geriatric care and rehabilitation for its patient-centered approach and sensitivity to cognitive and social dimensions of disability. It has demonstrated utility in assessing disability prevalence, predicting functional outcomes after dementia, and monitoring rehabilitation effectiveness in older adults. This review evaluated WHODAS 2.0’s application in older populations, identifying research gaps and clinical implications. A comprehensive literature search was conducted in PubMed/Medline, Scopus, Web of Science, Cochrane, and Embase in April 2025 by using the keywords “WHODAS,” “Elderly,” “Geriatric,” and “Disability” without time restrictions. Studies evaluating disability in …
L3 Extraforaminal Herniated Intervertebral Disc Masquerading As Knee Disorder, Ming-Yen Hsiao, Chueh-Hung Wu, Tyng-Guey Wang
L3 Extraforaminal Herniated Intervertebral Disc Masquerading As Knee Disorder, Ming-Yen Hsiao, Chueh-Hung Wu, Tyng-Guey Wang
Rehabilitation Practice and Science
No abstract provided.
Msw Portfolio, Ashley V. Sifuentes
Msw Portfolio, Ashley V. Sifuentes
Graduate Student Portfolios, Professional Papers, and Capstone Projects
Growing into my voice, my journey throughout the MSW program.
E-Payment Systems Use: The Role Of Cybersecurity Risk And The Moderating Effect Of Risk Propensity And Technology Readiness, Abdou Illia, Hyunsun Kim-Hahm, Thomas Ngniatedema, Mahaman Sani Yakoubou
E-Payment Systems Use: The Role Of Cybersecurity Risk And The Moderating Effect Of Risk Propensity And Technology Readiness, Abdou Illia, Hyunsun Kim-Hahm, Thomas Ngniatedema, Mahaman Sani Yakoubou
Journal of International Technology and Information Management
Advances in digitalization have accelerated consumer migrations away from traditional cash- and check-based payment systems towards electronic payment systems worldwide. Yet, many people still remain resistant. This study examined the role of motivational and inhibiting factors and their interaction effects on the use of e-payment systems. The findings suggest that perceived cybersecurity risk, risk propensity, trust in the companies offering the e-payment services, and technology readiness have a significant direct impact on the use of e-payment systems. The findings also suggest that risk propensity and technology readiness have a tempering effect on the negative impact of perceived risk. The study …
Business Process Redesign For Reducing Undelivered Product Return Losses In E-Commerce – An Explainable Ai Approach, Venkataraghavan Krishnaswamy, Deepa R, Himanshu Sharma
Business Process Redesign For Reducing Undelivered Product Return Losses In E-Commerce – An Explainable Ai Approach, Venkataraghavan Krishnaswamy, Deepa R, Himanshu Sharma
Journal of International Technology and Information Management
Product returns in e-commerce affect the profitability of the e-tailer. We adopt a two-stage approach to reduce undelivered product returns in an e-commerce firm. First, we develop and compare machine learning techniques—logistic regression, decision trees, Naïve Bayes, random forest, adaptive boosting, gradient boosting, stochastic gradient boosting, and deep neural networks—on their ability to predict undelivered returns. Next, we use explainable methods, such as relative importance and Shapley values, to develop insights from the best-performing machine learning model. Finally, we use these insights and the predictive model to redesign the firm’s order fulfillment and return processes. A Post-implementation evaluation of the …
Climate Preemption And Fossil Fuel Entrenchment, Vincent M. Nolette
Climate Preemption And Fossil Fuel Entrenchment, Vincent M. Nolette
Sabin Center for Climate Change Law
Mitigating the worst impacts of climate change demands a rapid reduction in greenhouse gas emissions and a transition to renewable, low-carbon sources of energy. This requires building thousands of gigawatts of clean energy at an unprecedented rate and expeditiously retiring existing fossil fuel infrastructure. Yet both parts of this task have been obstructed by state legislative efforts over the last decade — particularly in Republican-led states — to block local governments from reducing greenhouse gas emissions while legally mandating continued fossil fuel reliance. These efforts are accomplished through state climate preemption laws. Framed in neutral or positive terms like “energy …
College Of Liberal Arts Faculty Bylaws 2026-2027 - Amended 09/2026), College Of Liberal Arts Faculty, Rollins College
College Of Liberal Arts Faculty Bylaws 2026-2027 - Amended 09/2026), College Of Liberal Arts Faculty, Rollins College
College of Liberal Arts Bylaws
No abstract provided.
Treatment Manual For Nonsequential Format Two Part Program For Symptom Self-Management (12 Session Course & Support Group For Booster Dose Of Course), Robin Kay Buccheri, Louise Nigh Trygstad, Martha D. Buffum
Treatment Manual For Nonsequential Format Two Part Program For Symptom Self-Management (12 Session Course & Support Group For Booster Dose Of Course), Robin Kay Buccheri, Louise Nigh Trygstad, Martha D. Buffum
Nursing and Health Professions Faculty Research and Publications
This is the Treatment Manual and 5 Appendices for NonSequential Format. Two-Part Program for Symptom Self-Management of Auditory Hallucinations: 12 Session Course & Support Group for Booster Dose of Course
Winter 2026, Southwestern Oklahoma State University Office Of Institutional Advancement And Alumni
Winter 2026, Southwestern Oklahoma State University Office Of Institutional Advancement And Alumni
Echoes from the Hill
From The Interim President
Fellow members of the SWOSU Community,
I have been grateful for the opportunity to serve Southwestern Oklahoma State University for nearly three decades. As the Spring 2026 semester gets underway, we welcome the opportunity to pause and reflect on what we have learned—and what we continue to achieve together.
The bonds formed among our students, faculty, and staff as we deliver high quality, affordable programs of instruction and training are deep and enduring. The Southwestern Spirit—marked by friendly cooperation, thoughtful inquiry, and hard work—gives SWOSU a distinctive strength and instills in our graduates a lasting sense …
Spring/Summer 2026, Southwestern Oklahoma State University Office Of Institutional Advancement And Alumni
Spring/Summer 2026, Southwestern Oklahoma State University Office Of Institutional Advancement And Alumni
Echoes from the Hill
From The President
SWOSU Community,
SWOSU is 125 years old this year, and 2026 has been an exciting year here on the Hilltop! We are gearing up for a great Fall Semester!
This issue of Echoes highlights the wonderful time we had in the Spring when our students, faculty, and staff joined donors, alumni, dignitaries, and community leaders from throughout Oklahoma and beyond for the dedication of the Jerry & Margaret Hodge Center for Pharmacy & Rural Health. The Center represents an innovative private-public partnership that will enable our university to graduate more healthcare professionals to meet the workforce needs …
Could Have Seen That Coming: New York State Department Of Health Taken To Task For Failing To Provide Proper Oversight Of Medicaid Managed Care Provider Networks, Lance Plunkett Jd, Llm
Could Have Seen That Coming: New York State Department Of Health Taken To Task For Failing To Provide Proper Oversight Of Medicaid Managed Care Provider Networks, Lance Plunkett Jd, Llm
The New York State Dental Journal
A recent audit conducted by the Office of the New York State Comptroller (OSC) found that the New York State Department of Health (NYSDOH) oversight of Medicaid managed care healthcare provider networks was largely illusory and a paperwork sham. This raises the much larger question of whether Medicaid managed care is really serving the population of Medicaid patients. It is already almost a given that it is not serving healthcare providers well.
Tramadol For Treatment Of Neurogenic Cough: A Retrospective Case Series, Benjamin Joseph Rubinstein, Sheela Saidha, John Todd Sinacori
Tramadol For Treatment Of Neurogenic Cough: A Retrospective Case Series, Benjamin Joseph Rubinstein, Sheela Saidha, John Todd Sinacori
Department of Otolaryngology (ENT) Faculty Publications
Objectives
Explore the efficacy of tramadol for neurogenic cough and describe the longitudinal treatment experience.
Methods
A retrospective case series of adults with chronic cough who were treated with tramadol for neurogenic cough. A complete response was defined as no pathologic coughing, and a partial response was defined as 50% or greater reduction in severity or frequency.
Results
Sixty-nine patients were included. 38% of patients reported a complete response with an additional 33% reporting a partial response. The most common successful dosing regimen was 50 mg BID. Age, gender, and BMI did not impact treatment response. Patients with a history …
Reply To: S. N. Katkuri Et Al. And H. Liu Et Al. On Early And Sustained Improvements In Sense Of Smell With Tezepelumab Treatment In Patients With Chronic Rhinosinusitis With Nasal Polyps (Waypoint), Joaquim Mullol, Joseph K. Han, Tanya M. Laidlaw, Claire Hopkins, Anju T. Peters, Oliver Pfaar, Martin Desrosiers, Stella E. Lee, Andrew P. Lane, Claudia Chen, Yun Chon, Sandhia S. Ponnarambil, Andrew Foster, Andrew W. Lindsley, Christopher S. Ambrose
Reply To: S. N. Katkuri Et Al. And H. Liu Et Al. On Early And Sustained Improvements In Sense Of Smell With Tezepelumab Treatment In Patients With Chronic Rhinosinusitis With Nasal Polyps (Waypoint), Joaquim Mullol, Joseph K. Han, Tanya M. Laidlaw, Claire Hopkins, Anju T. Peters, Oliver Pfaar, Martin Desrosiers, Stella E. Lee, Andrew P. Lane, Claudia Chen, Yun Chon, Sandhia S. Ponnarambil, Andrew Foster, Andrew W. Lindsley, Christopher S. Ambrose
Department of Otolaryngology (ENT) Faculty Publications
[Introduction] We thank Dr. S. N. Katkuri, Dr. H. Liu, and their coauthors [1, 2] for their interest in our recent publication describing the improvements in loss of smell symptoms with tezepelumab versus placebo in patients with uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP) in the WAYPOINT trial (NCT04851964) [3]. We are grateful for the authors' feedback on the clinical significance of the data presented and their appreciation of the consistency observed across a range of baseline clinical characteristic and demographic subgroups.
Early And Sustained Improvements In Sense Of Smell With Tezepelumab Treatment In Patients With Chronic Rhinosinusitis With Nasal Polyps (Waypoint), Joaquim Mullol, Joseph K. Han, Tanya M. Laidlaw, Claire Hopkins, Anju T. Peters, Oliver Pfaar, Martin Desrosiers, Stella E. Lee, Andrew P. Lane, Claudia Chen, Yun Chon, Sandhia S. Ponnarambil, Andrews Foster, Andrew W. Lindsley, Christopher S. Ambrose
Early And Sustained Improvements In Sense Of Smell With Tezepelumab Treatment In Patients With Chronic Rhinosinusitis With Nasal Polyps (Waypoint), Joaquim Mullol, Joseph K. Han, Tanya M. Laidlaw, Claire Hopkins, Anju T. Peters, Oliver Pfaar, Martin Desrosiers, Stella E. Lee, Andrew P. Lane, Claudia Chen, Yun Chon, Sandhia S. Ponnarambil, Andrews Foster, Andrew W. Lindsley, Christopher S. Ambrose
Department of Otolaryngology (ENT) Faculty Publications
Background
Loss of smell is a principal symptom of chronic rhinosinusitis with nasal polyps (CRSwNP), affecting health-related quality of life and posing a safety hazard.
Methods
WAYPOINT (NCT04851964), a phase 3, multicenter trial in adults with uncontrolled CRSwNP, randomized patients 1:1 to receive tezepelumab 210 mg or placebo subcutaneously every 4 weeks for 52 weeks. Changes from baseline in biweekly mean Nasal Polyposis Symptom Diary (NPSD) loss of smell item, University of Pennsylvania Smell Identification Test (UPSIT), and 22-item Sino-Nasal Outcome Test (SNOT-22) loss of smell/taste item scores, as well as anosmia (UPSIT score ≤18) prevalence, were assessed over 52 …
Progression Of Mild Sleep-Disordered Breathing In Children Managed With Watchful Waiting, Erin M. Kirkham, Stacey Ishman, Susan Garetz, Cristina M. Baldassari, Ron B. Mitchell, Christopher Liu, Ignacio E. Tapia, Lisa M. Elden, Fauziya Hassan, Sally Ibrahim, Kristie Ross, Mengqi Cen, Rui Wang, Susan Redline, Ronald D. Chervin
Progression Of Mild Sleep-Disordered Breathing In Children Managed With Watchful Waiting, Erin M. Kirkham, Stacey Ishman, Susan Garetz, Cristina M. Baldassari, Ron B. Mitchell, Christopher Liu, Ignacio E. Tapia, Lisa M. Elden, Fauziya Hassan, Sally Ibrahim, Kristie Ross, Mengqi Cen, Rui Wang, Susan Redline, Ronald D. Chervin
Department of Otolaryngology (ENT) Faculty Publications
Purpose
To identify clinical characteristics that may be associated with persistence or progression of mild sleep-disordered breathing (SDB) in children who are observed without surgery.
Methods
This is a secondary analysis of the control arm of the Pediatric Adenotonsillectomy Trial for Snoring (PATS), which randomized 458 children aged 3.0 to 12.9 years with mild SDB (snoring with obstructive apnea-hypopnea index [oAHI] < 3 events/hour) to early adenotonsillectomy (eAT) versus watchful waiting with supportive care (WWSC). Participants were assessed at baseline and 12 months with the Pediatric Sleep Questionnaire-Sleep-Related Breathing Disorder (PSQ-SRBD) scale and polysomnography (PSG). We tested for factors predictive of either (1) PSG progression defined by a 12-month oAHI ≥ 3 or (2) symptom persistence or progression defined by a 12-month PSQ-SRBD score ≥ 0.33.
Results
A total of 234 participants were observed (mean age 6.2 years, 111 [47%] female, 65 [28%] Black or African American, 37 [16%] Hispanic). Overall, only 13% (n = 20/150) progressed to an oAHI ≥ 3 on repeat PSG, …
Use Of Tezepelumab For Chronic Rhinosinusitis With Nasal Polyps By Eosinophilic Endotype: Waypoint Post-Hoc Analysis, Shigeharu Fujieda, Nobuyoshi Otori, Joseph K. Han, Tadataka Yabuta, Claudia Chen, Claudio Marchese, Andrews Foster, Sandhia S. Ponnarambil, Yun Chan, Brian J. Lipworth
Use Of Tezepelumab For Chronic Rhinosinusitis With Nasal Polyps By Eosinophilic Endotype: Waypoint Post-Hoc Analysis, Shigeharu Fujieda, Nobuyoshi Otori, Joseph K. Han, Tadataka Yabuta, Claudia Chen, Claudio Marchese, Andrews Foster, Sandhia S. Ponnarambil, Yun Chan, Brian J. Lipworth
Department of Otolaryngology (ENT) Faculty Publications
Background
The phase 3 WAYPOINT study (NCT04851964) reported that tezepelumab improved outcomes in patients with chronic rhinosinusitis with nasal polyps (CRSwNP), including nasal polyp size, nasal congestion, and sinonasal symptoms, and reduced the need for surgery and systemic corticosteroids (SCS).
Objective
To evaluate the efficacy and safety of tezepelumab across Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis-defined eosinophilic chronic rhinosinusitis (ECRS) subgroups.
Methods
Adults with severe CRSwNP were randomized to tezepelumab 210 mg or placebo every 4 weeks. Coprimary end points were the change from baseline to week 52 in total Nasal Polyp Score and the biweekly mean Nasal …