Digital Commons Network^™

Evaluation Of The Physical Properties And In Vitro Safety Of Chitosan-Quercus Infectoria Topical Gel, Rani Naga Rakshitha Tillapudi

Theses, Dissertations and Capstones

Due to ongoing inflammation, inadequate blood flow, oxidative stress, and reduced tissue regeneration, chronic diabetic wounds heal slowly, which is a serious health concern. It is important to examine novel strategies that tackle these issues because conventional treatments frequently fail. Therefore, this study examined the physical properties and biocompatibility of a novel topical gel formulated with chitosan and Quercus infectoria gall extract.

Over 28 days, pH, spreadability, texture, homogeneity, color, and drug concentration were assessed. UV-visible spectrophotometry and FTIR analysis were used to establish chemical stability. The MTT assay was used to test its safety in human dermal fibroblast adult …

Tax Laws And Proportionality: Analyzing Implementation And Advocating For Reform, Moshe A. Jaffe

SJD Dissertations

The application of judicial review to tax legislation presents unique challenges and inconsistencies. This study contends that the proportionality doctrine, widely used in numerous legal systems, offers the best framework for reviewing the constitutionality of tax laws. By examining the implementation of proportionality in countries such as Germany, Israel, and Canada, this research argues that adopting this doctrine—excluding the Stricto Sensu sub-test—could provide a more consistent and fair method for judicial review of tax legislation. Specifically, this approach avoids the indeterminacy and subjectivity often associated with open-ended balancing, while still ensuring that tax measures serve legitimate aims and employ means …

Mitochondrial Transfer To Granulocytic Myeloid-Derived Suppressor Cells Augments Immunosuppressive Activity, Prabhakar Arumugam, Cortney E. Heim, Rachel W. Fallet, Dhananjay Shinde, Vinai Chittezham Thomas, Rafael J. Argüello, Tammy Kielian

Journal Articles: Pathology and Microbiology

The anti-inflammatory properties of granulocytic myeloid-derived suppressor cells (G-MDSCs) promote Staphylococcus aureus (S. aureus) biofilm persistence. Evidence suggests that G-MDSC activity is shaped not only by S. aureus products but also by intrinsic metabolic programs. This study explores whether G-MDSC activity can be modulated by increasing mitochondrial abundance using a co-culture paradigm with macrophages as a mitochondrial donor. Macrophages transfer mitochondria directly to G-MDSCs via tunneling nanotubes, enhancing G-MDSC respiration, as reflected by increased basal, maximal, and spare respiratory capacity. Augmenting mitochondrial abundance in G-MDSCs enhances T cell-suppressive activity and reduces tumor necrosis factor (TNF) and interleukin 6 (IL-6) production. …

Ransomware As Organization: A Comparative Analysis Of Corporate And Criminal Structures In Conti, George Urling

Theses, Dissertations and Capstones

Cybercriminal groups continue to pose major threats to global cybersecurity. One of the most common types of cybercriminal groups are, “Ransomware-as-a-Service (RaaS)" groups, who create and sell ransomware. While research is conducted into the development of ransomware, there is limited reporting on the organizational structure and habits of RaaS groups. In 2022, prominent RaaS group Conti had their chat logs leaked, with the logs ranging from 2020 to 2022. This study seeks to provide a deeper understanding of RaaS group structures by utilizing the Conti leaked logs as a case study. The study, entitled “Ransomware as Organization: A Comparative Analysis …

Seagrassnet Monitoring In The Great Bay Estuary, Nh/Me Field Season 2025, Kalle Matso, Lara Martin, Christopher Whitney, Trevor Mattera, Amanda Giacchetti, David M. Burdick, Thomas Gregory

PREP Reports & Publications

No abstract provided.

Choco Pies, Economic Gains, And The Opening Of North Korea:, Quinci Rasband

BYU Asian Studies Student Journal

Since the armistice was signed putting a hold on the Korean War (July 27, 1953) and officially created two separate entities, has there ever been a time when North Korea and South Korea—two diametrically opposed countries— worked together towards a common goal? If there really was such a time when North Korea and South Korea collaborated, one can wonder how this was received in the minds of North Koreans and South Koreans. While it is challenging to understand North Korean citizens’ perceptions of events, delving into accessible sources can shed light onto South Korea’s viewpoint of inter-Korean relations. One such …

The Hallyu Hexagon:, Katherine Linton

BYU Asian Studies Student Journal

From the opening credits, Crash Landing On You1 captured the attention and adoration of millions. The show follows a South Korean chaebol heiress, Yoon Se-ri, who crash lands into the North Korean side of the Demilitarized Zone. She is discovered by North Korean soldier, Ri Jeong Hyeok, who mercifully decides not to kill her on the spot. Over the course of 16 episodes and 23 hours, as Ri Jeong Hyeok betrays loyalty lines by evading the North Korean Military Police and helping Yoon Se-ri return to the south, the two’s fateful meeting evolves into a cross-border romance.

Korean dramas are …

Full Issue

BYU Asian Studies Student Journal

No abstract provided.

Made For War, Abandoned In Peace:, Michelle Parada-Gonzalez

BYU Asian Studies Student Journal

Amid a raging blizzard in the mountains of 1907 Hokkaido, Sugimoto Saichi shelters inside the still-warm carcass of a freshly killed deer, huddled beside his companion, Asirpa. As she asks if his wounds still hurt, he brushes it off, insisting that the man he killed earlier had no human heart and felt little pain. When Asirpa reprimands him, Sugimoto concedes—war has changed him. The person he once was had been left behind on the battlefield. Some men, he says, can return to their old lives, but others like him remain stuck in the past. Asirpa, only twelve years old, considers …

The Second Great Reform:, Margaret Jeppesen

BYU Asian Studies Student Journal

Beginning in 1978 under Deng Xiaoping’s leadership, China launched the Great Economic Reform, also known as the Opening-up, as the nation transitioned from a centrally planned system to a market-oriented economy. In a single generation, millions were lifted out of poverty establishing China as a global economic superpower. Since then, China has placed great emphasis on maintaining a continuous economic upward trend and achieving technological self-sufficiency.

The development of artificial intelligence plays a prominent role in China’s second great reform to become a technological superpower. In 2017, President Xi Jinping introduced the New Generation Artificial Intelligence Development Plan (AIDP) —a …

Lifestyle Factors' Effect On Political And Religious Behavior, Madison A. Price

SPARK Symposium Presentations

There is a general understanding of an individuals’ political/religious beliefs when you analyze predictors like support of same sex marriage or views on abortion, but there is not a ton of research on how everyday lifestyle factors might affect how someone aligns themselves politically or religiously. Researchers have begun to expand the horizons of political and religious research by investigating how income, health, and politics affect religion (Francis-Tan & Tian, 2022), but there is a need to expand into more specific lifestyle factors. Which brings reason to question a few things: what lifestyle and demographic factors predict how religious someone …

Ecological Renovation Of Belmont Tennis Courts, Abbie E. Hamilton, Smith David, Darlene Panvini

SPARK Symposium Presentations

Although Belmont works hard to establish adequate green spaces on our campus, there is much work to be done if we want our students and the wildlife around us to maximize their ecosystem services. More specifically, Belmont can strive to implement nature-based solutions for its athletes, who are often competing in highly urbanized facilities. For this project, we have decided to redesign Belmont’s Tennis Courts, improving their design by increasing their green infrastructure. Our new design was created from a biophilic perspective and intends to serve all aspects of the triple bottom line. The new tennis courts will include ecologically …

Life At Friends Life Community: Exploring The Goals And Relationships At An Adult Day Program, Ella Pursley

SPARK Symposium Presentations

Our research examines the perceived quality of life of participants in a day program for adults with intellectual and developmental disabilities. Our research took place at Friends Life Community in Nashville, Tennessee and is a mixed-methods study. Using the Council on Quality and Leadership’s (CQL) Personal Outcome Measures, we interviewed ten participants to determine whether they saw themselves as having the Outcome Measures of Goals and Personal Relationships. The current literature surrounding adults with intellectual and developmental disabilities typically includes the voices of their caregivers, teachers, and friends but excludes the voices of this population. Our research aims to give …

Evaluating The Impact Of Tennessee House Bill 2327 & Senate Bill 2055, Kya Cousino, Emily Redford, Leah M. Vetters

SPARK Symposium Presentations

Students with autism spectrum disorder (ASD) and developmental delays often require consistent therapeutic interventions such as speech therapy, occupational therapy (OT), or applied behavior analysis (ABA) in order to meaningfully access their education (Treatment and Intervention for Autism Spectrum Disorder, 2024). However, service shortages, scheduling barriers, and restrictions on outside providers during the school day frequently create gaps in care. As a result, families may be forced to choose between their child’s educational attendance and the continuity of medically or developmentally necessary services.

House Bill 2327 and corresponding Senate Bill 2055 seek to address this barrier by requiring Local Education …

Chemotherapy Exposure Alters Heart Rate In Daphnia Magna: A Rapid Model For Evaluating Cardiotoxicity, Leland B. Wythoff, Andrea Florian

SPARK Symposium Presentations

Chemotherapy agents such as 5-Fluorouracil and Oxaliplatin are commonly employed in the management of various types of cancer. However, they have been implicated as causative factors of various side effects related to the heart. Drug-induced cardiotoxicity in rapid preclinical models could be employed as an effective tool for the identification of adverse effects. Daphnia magna is a small aquatic organism that is frequently employed in toxicological tests due to its transparent body that allows direct observation of physiological activities such as heart rates.

The purpose of the study was to evaluate the effect of various concentrations of 5-Fluorouracil and Oxaliplatin …

Dred Scott By Any Other Name: The New War Over Abortion And The Right To Travel After Dobbs, Wesley Mark Kimler

SPARK Symposium Presentations

After the decision in Dred Scott v. Sandford and the Fugitive Slave Acts, slave states could effectively undermine the laws of free Northern states and deny African Americans the constitutional right to travel. Today, the denial of that right is faced by a different group. Where once the right to travel was denied to African Americans, it is now being denied to women and pregnant people. In addition to banning abortion, several states have enacted so-called "abortion trafficking" laws which make it a crime to assist a minor in procuring an abortion, even if that abortion is to take place …

A Macrocognitive Design Taxonomy For Simulation-Based Training Systems: Bridging Cognitive Theory And Human-Computer Interaction, Jessica M. Johnson

Virginia Digital Maritime Center (VDMC) Faculty Publications

Simulation-based training systems are increasingly deployed to prepare learners for complex, safety-critical, and dynamic work environments. While advances in computing have enabled immersive and data-rich simulations, many systems remain optimized for procedural accuracy and surface-level task performance rather than the macrocognitive processes that underpin adaptive expertise. Macrocognition encompasses higher-order cognitive processes that are essential for performance transfer beyond controlled training conditions. When these processes are insufficiently supported, training systems risk fostering brittle strategies and negative training effects. This paper introduces a macrocognitive design taxonomy for simulation-based training systems derived from a large-scale meta-analysis examining the transfer of macrocognitive skills from …

Hfpo-Da Aquatic Toxicity And Bioaccumulation, Bailey Dawn Rappold

Theses, Dissertations and Capstones

Per- and polyfluoroalkyl substances (PFAS) have been detected globally in environmental media and biota. Legacy compounds PFOA and PFOS have been observed to be toxic and bioaccumulative in low doses and have been removed from production and industrial processes. Replacement PFAS chemicals are less understood and present a gap in current knowledge in their toxicological effects. This research utilized extended chronic toxicity studies to assess the impacts of HFPO-DA, a short chain replacement PFAS, on the standard aquatic toxicology organism Pimephales promelas. Organisms were exposed for 29 to 30 days at environmentally relevant concentrations of the toxicant, 7.8125 ng/L …

Dnp Repository: Using Technology To Help Nurse Leaders Make A Global Impact, Cynthia Plonien, Cathy Brown, Vanessa Garrett

Nursing Faculty Publications & Presentations - Archive

No abstract provided.

Adverse Childhood Experiences And Intellectual Disabilities: A Population-Based Comparison, Sarah Hurst, Astrida S. Kaugars

Modern Psychological Studies

Childhood is a critical time for development, and negative experiences during this period may have lasting consequences. Children with intellectual disabilities (ID) are at greater risk for adverse childhood experiences (ACEs) than children without ID. Using data from the 2022 National Survey of Children’s Health (U.S. Census Bureau), we assessed the frequency of ACEs reported based on IDs. Participants were caregivers of 528 children currently diagnosed with an ID and a random sample of 528 children selected from the remaining 49,755 respondents without an ID. As hypothesized, parents of children with ID reported a statistically significant greater number of total …

Development Of A Physiologically Based Pharmacokinetic (Pbpk) Simulation Model For Nicotine, Brian Kim, Sung Hun Bae, Mohamed Bashar, Bofang Yi, Mohammad Asikur Rahman, Prince Awuah, Matthew Hartog, Rony Panarsky, Tao Zhang

Pharmacy Faculty Scholarship

Tobacco is a major cause of chronic diseases such as lung cancer, cardiovascular disease, and chronic obstructive pulmonary disease worldwide. Nicotine, the primary psychoactive component in tobacco, is highly addictive and while not the primary driver of such tobacco-related diseases, poses various health risks, particularly those affecting the cardiovascular and pulmonary systems. Although nicotine-based therapies, such as nicotine replacement products, are widely utilized in smoking cessation efforts today, the impact of newer, tobacco delivery systems such as electronic nicotine delivery systems, or ENDS, remains uncertain and warrants continued evaluation. This study aims to develop and validate a physiologically based pharmacokinetic …

Monroe, New Hampshire Annual Report Of The Monroe Town Officers For The Year Ending December 31, 2025, Monroe Town Representatives

Monroe, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Notre Dame [Lawyer] Judge - 2026, Notre Dame Law School

Notre Dame Lawyer

Cover

25 U.S. Supreme Court Justice Amy Coney Barrett

31 The Rise of Chancellor Kathaleen McCormick

39 Justice Mbuyiseli Madlanga and the Pursuit of Justice

05 News

71 Alumni

81 Faculty

Judicial Profiles

35 Judge Ann Claire Williams ’75 J.D.

37 Q&A: Judge John Blakey ’88, ’92 J.D.

38 Judge Martha Vázquez ’75, ’78 J.D. ’43

43 Q&A: Judge Edward S. Kiel ’91 J.D.

45 Four Alumni: Their Roles as Federal Magistrate Judges

47 Judge Jerry Pappert ’88 J.D.

49 Justice Mary Yu ’93 J.D.

51 Judge Charles R. Wilson ’76, ’79 J.D.

53 The Specialists: Article I Federal Court …

Olli Spring 2026 Catalog, Toniann Leavitt

Osher Lifelong Learning Institute

No abstract provided.

Meta-Analysis: Diabetes Mellitus And The Risk Of Endometrial Cancer, Tricia Ho, Marika Ongpauco, Han Ha Ngoc Nguyen

Physician Assistant Studies | Graduate Research Papers

Background: Many studies have looked at the relationship between diabetes mellitus and development of endometrial cancer. This study provides an updated systematic review and meta-analysis of the estimated effect of diabetes and the risk of endometrial cancer.

Methods: Some studies were found on databases such as PubMed and Iceberg. The remaining studies were extracted from the initial studies found. Binary data was collected and the raw data was imputed into a Fixed Effects Model.

Results: A total of 25 studies were included in this meta-analysis, generating statistically significant results (p < 0.001, OR 2.05, 95% Cl 1.92-2.19).

Discussion: Diabetes is found to be …

The Effects Of Antidepressant Medications On Sleep Quality In Dominican University Of California Students, Natalie L. Davis, Kenna Wohlford, Stephanie Lee

Physician Assistant Studies | Graduate Research Papers

We spend approximately one third of our life time sleeping or attempting to sleep. The quality of our sleep is equally, if not more important than the amount of sleep we get. This study assesses the effects that medications, specifically antidepressants, can have on sleep quality in Dominican University of California students. 118 participants completed a Qualtrics survey including questions regarding stress, sleep quality, medication lists, and demographics. This study utilized the Pittsburgh Sleep Quality Index (PSQI) to quantify participants’ sleep quality as the outcome. Participant stress levels were assessed with a Likert scale question asking for stress levels on …

Cpaf In Focus Vol. 11 One On One : Reflections On Change And Impact, Michiko Karissa M. Buot, Johnnelda P. Cosep, Paulo C. Aquino, Therese Marie L. Quilnat, V. Bruce J. Tolentino, Agustin L. Arcenas, Samantha Geraldine G. De Los Santos, Guinevere T. Madlangbayan, Raizza F. Acuzar

IN FOCUS: Development & Governance

This volume of In Focus invites its readers to have a one-on-one with stories exploring how small acts of change can grow into waves of impact in governance and development -- From alumni who continue to excel beyond the university, to students recognized for academic achievements, to field notes from our research centers that ground theory in practice. We will also feature reflective think pieces from experts in governance and development, alongside an infographic highlighting the recently concluded ICGD4. At its core, the magazine asks its readers to reflect: how can individual acts of change create lasting impact? 

Editorial Team …

Annual Report Of Town Officials, Departments, And Committees, Town Of Acworth, New Hampshire For The Year Ending December 31, 2025, Acworth Town Representatives

Acworth, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Grass: Place-Based Learning Plan For The Msum Regional Science Center, Riley Schaefer

OER Materials

The goal of this assignment was to design an immersive place-based learning experience that helps preservice teachers engage with their resources and design an inclusive place-based learning plan. Connecting to the MSUM Regional Science center where these resources will be made for. They are subject to change for other regional centers like the MSUM Regional Science Center.

Annual Reports Town Of Marlow, N.H. For The Year Ending December 31, 2025 And Marlow School District For The Year Ending June 30, 2025, Marlow Town Representatives

Marlow, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.