Digital Commons Network^™

N-Palmitoyl Glutamine Is A Candidate Mediator Of Cardiorespiratory Fitness, Jeremy M Robbins, Mark Benson, Anthony R P Verkerke, Gaurav Tiwari, Shuliang Deng, Prashant Rao, Usman A Tahir, Julian Avila-Pacheco, Xu Shi, Yuntian Guan, Foje-Geh Tendoh, Jacob L Barber, Patricia E Miller, Andrew S Perry, Michael E Hall, Alexis C Wood, Kent D Taylor, Wendy S Post, Stephen S Rich, Matthew Nayor, James G Wilson, Gregory D Lewis, Ravi V Shah, Jerome I Rotter, Scott A Summers, Laura M Raffield, Shingo Kajimura, Claude Bouchard, Clary B Clish, Mark A Sarzynski, Robert E Gerszten

Children’s Nutrition Research Center Staff Publications

Background: Cardiorespiratory fitness is an integrative measure of cardiometabolic health and predictor of survival, yet little is known about its molecular underpinnings. Small molecule metabolites and lipids are increasingly recognized as exercise-stimulated signaling molecules and candidate molecular transducers of cardiorespiratory fitness.

Methods: We performed nontargeted liquid chromatography mass spectrometry-based plasma metabolomics in 654 participants (mean age, 35 years; 55% women) from the HERITAGE Family Study (Health, Risk Factors, Exercise Training, and Genetics) who had cardiorespiratory fitness (maximal oxygen uptake [VO2max]) measured by cardiopulmonary exercise testing and underwent 20 weeks of supervised endurance training. Metabolite-VO2max relationships were assessed using linear regression …

Loss Of Twist1 Leads To Disruption Of Ciliary Length, Endocytic Vesicle Dynamics, And Cell-Cell Junctions During Neural Tube Formation, Derrick Thomas, Brittany M Hufft-Martinez, Zarna Lalwani, Vi Pham, Mary Elmeniawi, An J Tran, Jianming Xu, Irfan Saadi, Walid D Fakhouri

Faculty, Staff and Student Publications

Background: Endocytosis constitutes a fundamental cellular process governing development through coordinated regulation of plasma membrane remodeling and ciliogenesis, processes essential for cell shape changes and tissue development. Although Twist1 null embryos display complete cranial neural tube (NT) closure defects and conditional knockout in neuroectoderm disrupts cranial neural crest cell fate determination and delamination, the function of TWIST1 in NT morphogenesis remains unknown. We investigated the basis underlying neuroectodermal morphological abnormalities in TWIST1 mutant embryos, specifically the formation of ectopic lateral bending points and cellular disorganization, by examining Twist1's role in cilia formation, adherens junction integrity, and endocytic vesicle dynamics.

Results: …

Association Between Ultraprocessed Food Consumption And Cardiovascular Disease Risk: Mesa (Multiethnic Study Of Atherosclerosis), Amier Haidar, Rishi Rikhi, Karol E Watson, Alexis C Wood, Michael D Shapiro

Children’s Nutrition Research Center Staff Publications

Background: Ultraprocessed foods (UPFs) have been linked to adverse cardiometabolic outcomes and increased atherosclerotic cardiovascular disease (CVD) (ASCVD) risk. However, prior research has largely focused on homogenous populations, lacking racial and ethnic diversity.

Objectives: The objectives are to examine the longitudinal relationship between UPF consumption and ASCVD risk and to investigate whether these associations differ by race/ethnicity, sex, or socioeconomic status.

Methods: The MESA (Multiethnic Study of Atherosclerosis) is a prospective cohort study of 6,814 U.S. adults aged 45 to 84 years, without clinically apparent CVD. UPF consumption was classified according to the Nova classification system. Multivariable cox proportional hazards …

Predicting Sepsis In Heart Failure Patients Supported By Left Ventricular Assist Devices: The Role Of Ve-Cadherin And Adam10, Shiyi Li, Iván Murrieta-Álvarez, Ismael Garcia, Katherine V Nordick, Rishav Bhattacharya, Shreyo Ghosh, Ronald A Shaju, Adel M Hassan, Carl P Walther, Camila Hochman-Mendez, Alexis E Shafii, Kenneth K Liao, Nandan K Mondal

Faculty, Staff and Students Publications

Vascular endothelial cadherin (VE-Cadherin) is a major endothelial adhesion molecule and can be cleaved explicitly by metalloproteinase domain-containing protein 10 (ADAM10). Vascular hyperpermeability may contribute to a greater susceptibility to sepsis in left ventricular assist device (LVAD) support patients. We aim to evaluate the efficacy of VE-Cadherin and ADAM10 for predicting sepsis in LVAD patients. We prospectively recruited 50 patients with advanced heart failure receiving LVAD therapy. Baseline and weekly postoperative blood samples (weeks 1-4) were collected, and plasma VE-cadherin and ADAM10 levels were measured. Sepsis occurred in 9 of 50 patients (18.0%). Across all sampling points, plasma VE-cadherin and …

Development And Characterization Of Compression-Molded Chitosan Composite Films Reinforced With Silica And Titania Fillers, Bhuvaneswari Koti, Vuong Do, Yanika Schneider, Vimal Viswanathan

Faculty Research, Scholarly, and Creative Activity

This study investigates the development of biodegradable chitosan-based films as a sustainable alternative to conventional non-biodegradable food packaging materials. Chitosan, a naturally occurring polymer, possesses inherent film-forming ability and biodegradability; however, its limited mechanical and thermal properties constrain its practical applications. In this work, chitosan films were fabricated via compression molding, and their thermo-mechanical performance was systematically evaluated. The incorporation of fillers, such as titanium dioxide and silica, resulted in a 50% enhancement in tensile strength and an 86% improvement in flexibility. Further optimization of dual-filler compositions led to an additional 45% increase in elasticity, demonstrating the potential of synergistic …

Identifying Over- And Underfunded Diseases By Comparing National Institutes Of Health Funding For Skin Disease Research With Us Skin Disease Burden According To 2021 Global Burden Of Disease Data: Cross-Sectional Analysis, Aileen Park, Emily Woolhiser, Hannah Riva, Leo Wan, Haaris Kadri, Elizabeth Lamberty, Parks Juels, Sandra Jaroonwanichkul, Madison Reed, Catherine Hegedus, Dana Chen, Danielle Duffle, Jessica Kirk, Sydney Christensen, Emma Shelby, Robert Dellavalle

Student Publications

Background: Understanding the burden of various skin diseases can help guide funding allocation for skin disease research. A 2015 cross-sectional study found a partial correlation between US skin disease burden according to the 2010 Global Burden of Disease (GBD) study and National Institutes of Health (NIH) funding in 2012-2013.

Objective: This study aims to identify trends, correlations, and disparities in US skin disease burden and NIH research funding allocation using the latest data from the GBD 2021 and NIH funding data from the fiscal years 2021-2022.

Methods: A cross-sectional analysis was conducted to compare the disability-adjusted life years for 15 …

Erratum For Nachman Et Al., “Increased Fungal Burden In The Gastrointestinal Tract Of Brain-Dead Organ Donors”, Erika J Nachman, Colleen K Ardis, A Kyle B Ardis, Javier Nieto, Madeline M Bresson, Clare M Robertson, Maggie N Seale, Nora M Villafuerte, Zhe Lyu, Eva C Preisner, Heather A Danhof, Sara C Di Rienzi, Yolanda T Becker, Robert A Britton

Faculty, Staff and Students Publications

No abstract provided.

The Igvf Catalog-From Genetic Variation To Function, Daofeng Li, Shane Liu, Wenjin Zhang, Juan F Macias-Velasco, Tianjie Liu, Sarah Cody, Lucinda Antonacci-Fulton, Ting Wang, Et Al.

2020-Current year OA Pubs

Genomic variation between individuals is essential for understanding how differences in the genome sequence affect molecular and cellular processes. The Impact of Genomic Variation on Function (IGVF) Consortium aims to uncover the relationships among genomic variation, genome function, and phenotypes by combining experimental techniques, such as single-cell mapping and genomic perturbation assays, with computational approaches such as machine learning-based predictive modeling. The IGVF Data and Administrative Coordinating Centers collect, analyze, and disseminate data and results from across the consortium through an open-source platform called the IGVF Catalog. This resource includes, but is not limited to, data on the effects of …

Postoperative Lymph Is A Proximal Source Of Ctdna For Detection Of Recurrence In Hpv-Independent Head And Neck Cancer, Seka Lazare, Noah Earland, Peter Harris, Ricardo Ramirez, Benjamin Wahle, Sid Puram, Doug Adkins, Wade Thorstad, Rebecca Chernock, Aadel A Chaudhuri, Et Al.

2020-Current year OA Pubs

PURPOSE: Relapse is a major cause of failure in human papillomavirus-independent head and neck squamous cell carcinoma. Clinicopathologic criteria for adjuvant treatment remain imprecise and have not changed for decades. We investigated whether ctDNA in lymphatic exudate collected via surgical drains ("lymph") 24 hours after surgery identified molecular residual disease (MRD) and compared its performance with time-matched plasma.

EXPERIMENTAL DESIGN: Using an ultra-sensitive tumor-informed sequencing approach, tumor variants were called in lymph and plasma to classify patients as ctDNA positive or ctDNA negative, trained in an initial cohort of 36 patients, and replicated in an independent cohort of 37 patients. …

Mass Spectrometry Footprinting Reveals How Kinetic Stabilizers Counteract Transthyretin Dynamics Altered By Pathogenic Mutations, Francisca Pinheiro, Ravi Kant, Saketh Chemuru, Nathalia Varejão, Adrián Velázquez-Campoy, David Reverter, Irantzu Pallarès, Michael L Gross, Salvador Ventura

2020-Current year OA Pubs

The aggregation of transthyretin (TTR) results in life-threatening transthyretin amyloidosis. Familial forms of the disease arise from point mutations that destabilize the TTR tetramer, leading to its dissociation and/or monomer unfolding and subsequent formation of amyloid fibrils. Small molecules that kinetically stabilize the native tetramer effectively inhibit this aggregation. Although over 300 X-ray crystal structures of TTR have been determined, these data refer to a static structure and do not capture the conformational effects of mutations and ligand binding. Here, we demonstrate that hydrogen-deuterium exchange (HDX) and fast photochemical oxidation of proteins (FPOP) coupled with mass spectrometry (MS) offer critical …

Polymer Conformational Entropy As The Driver Of Complex Coacervation, Tommaso Inzani, Giovanni Nava, Marco Buscaglia, Andrea Soranno, Alessandro Gori, Greta Bergamaschi, Samir Suweis, Amos Maritan, Tommaso Bellini

2020-Current year OA Pubs

Understanding the mechanisms leading to complex coacervation is a fundamental challenge in biomolecular sciences. Here, we explored the condensation transition and pretransitional behavior of an archetypal system consisting of polyuridylic acid chains (PolyU) and short cationic peptides in buffered aqueous solutions. By combining static and dynamic light scattering with confocal microscopy, we determined the location of the transition and the partitioning of PolyU and peptides between the coexisting phases as a function of the total peptides/PolyU ratio. We find that upon adding peptides in the system, the size of PolyU coils in the single-phase region is progressively reduced by peptide-mediated …

What Is The Psychological And Cognitive Impact Of Returning Alzheimer Disease Dementia Research Results To Healthy Research Participants? A Delayed-Start Randomised Clinical Trial Protocol For The Weshare Study (Washington University Study Of Having Alzheimer Disease), Sarah M Hartz, Spondita Goswami, Amy Oliver, Alissa Evans, Sacha Jackson, Erin Linnenbringer, Krista M Moulder, John C Morris, Jessica Mozersky

2020-Current year OA Pubs

INTRODUCTION: Returning research results that indicate risk of Alzheimer disease (AD) dementia-a disease for which no meaningful treatments or cure exist-to cognitively normal participants is controversial. AD is thought to begin many years before clinical signs and symptoms begin. During this time, individuals are cognitively normal but have biomarkers that indicate pathophysiological changes in the brain. With this study, we aim to evaluate the impact of returning research results on cognitively normal participants recruited from a longitudinal observational cohort on ageing at the Knight Alzheimer Disease Research Centre (Knight ADRC) at Washington University in St. Louis.

METHODS AND ANALYSIS: Our …

Beta Boule Program, Zeta Phi Beta Sorority Incorporated

Josie Green Washington Papers

A program for the Zeta Phi Beta Sorority 32nd National Boule.

Pilots’ Perceived Cognitive Functions: The Effect Of Mental Workload And Mindfulness On Prospective Memory Performance, Zehra Nur Kurtoğlu, Pınar Ünsal Bayrakçı

International Journal of Aviation, Aeronautics, and Aerospace

Errors related to human factors remain a leading cause of aviation accidents, with many of these incidents being attributed to pilot performance. A key aspect of pilot performance might be prospective memory (PM), the ability to remember and execute future tasks at the appropriate time. The dynamic and high-demand environment of the cockpit presents significant challenges for pilots' PM, particularly due to high mental workload and the constant need for multitasking. This study investigates the impact of perceived mental workload as consisting of cognitive, emotional, temporal, and performance demands dimensions, and mindfulness on pilots' PM performance. A mindfulness scale specific …

32nd National Boule & 42nd Anniversary Conclave, Zeta Phi Beta Sorority Incorporated, Phi Beta Sigma Fraternity Incorporated

Josie Green Washington Papers

A sorority/fraternity program for the 32nd National Boule for the Zeta Phi Beta Sorority Incorporated and the 43rd Anniversary Conclave for the Phi Beta Sigma Fraternity Incorporated. This copy belongs to Josie Green Washington.

Navigating Privacy Boundaries: Communication Privacy Management And Faculty, Ashlee Ellinwood, Chloee Robison, Sarah Steimel

Speaker & Gavel

College students experience high levels of stress that impact their academic performance and persistence in higher education. While faculty support has been shown to enhance student success, little is known about the privacy management rules students use when deciding whether to disclose personal stressors to their instructors. This study uses Communication Privacy Management (CPM) theory to examine how undergraduate students develop and apply privacy rules regarding stress-related disclosures to faculty. Four key factors emerged through qualitative interviews and focus groups with 40 students: cultural norms, motivation, contextual influences, and risk-benefit assessments. Findings underscore the importance of faculty-student communication in student …

Volume 61, Issue 2, 2025 Speaker & Gavel Front Matter

Speaker & Gavel

Front matter and table of contents for Volume 61, Issue 2, 2025 of Speaker & Gavel.

Volume 61, Issue 2, 2025 Speaker & Gavel

Speaker & Gavel

Complete digital issue (Volume 61, issue 2, 2025) of Speaker & Gavel.

American Dental Association And Academy For Sports Dentistry Announce Collaboration To Advance Oral Health And Athlete Safety

New Orleans Dental Association News

Article announcing a new collaboration between the American Dental Association (ADA) and the Academy for Sports Dentistry (ASD) on as-yet undecided initiatives that could include educational opportunities and broader professional awareness of sports dentistry topics among current and future dentists.

The Illusion Of Sex-Ed As Panacea: Addressing Adolescent Sexual And Reproductive Health Disparities In Minnesota, Bernadette E. Whitely

Tapestries: Interwoven voices of local and global identities

Although many praise Minnesota for its strong healthcare system, the state still faces significant disparities in access to sexual and reproductive health (SRH) services and comprehensive sexuality education (CSE). These disparities in access are compounded by geographic location, socioeconomic status (SES), and race, with barriers across transportation, cost, and clinic availability further complicating these issues. Based on this understanding, this paper examines adolescent SRH disparities between the Twin Cities metropolitan area and northern rural regions in Minnesota, focusing specifically on unintended adolescent pregnancies and sexually transmitted infections (STIs). Building on this foundation, I apply Dr. Vanessa Voller’s “CSE-as-panacea” framework, which …

We Do Not Care To Be Silent: Resist The Demand To Self-Censor About Tyranny, Ice, And Genocide, Reece Robinson

Tapestries: Interwoven voices of local and global identities

Silence breaking, I argue, is a tool that must be employed as frequently as possible by as many people as possible. Using the tools of hope and courage, working through the barriers of fear and shame, we must be outspoken in our care for all people. This expression of care is so crucial because there are tyrannical forces at work across the globe who wish for nothing more than our silence. In that silence, the U.S. government is expanding its practices to unjustly detain and deport immigrants. To enforce this silence, the U.S. government, through ICE, is detaining journalists and …

President's Message

New Orleans Dental Association News

Inaugural monthly update from Dr. Claudia A. Cavallino, D.D.S. with details of recent events, upcoming activities and news from the association.

Noda News January 2026

New Orleans Dental Association News

New Orleans Dental Association (NODA) News includes regular columns with regional news impacting the New Orleans membership including: columns from the President and Executive Director, feature articles relating to the field of dentistry, association events and upcoming activities, component news, continuing education opportunities, and classifieds.

This issue welcomes a new president, Dr. Claudia Cavallino.

Saudi Heart Association Position Statement On Early Detection Of Subclinical Atherosclerosis In Clinical Practice, Waleed Alhabeeb, Abdelrahaman Almoghairi, Abdulhalim Kinsara, Abdullah Khoja

Journal of the Saudi Heart Association

Background: Atherosclerosis is the leading underlying cause of cardiovascular disease (CVD), which remains the primary cause of mortality in Saudi Arabia. Saudi patients experience CVD events nearly a decade earlier than their Western counterparts. Given the limitations of traditional risk assessment tools, there is a growing need to detect subclinical atherosclerosis to refine risk stratification and improve primary prevention strategies, particularly in younger and asymptomatic individuals.

Methods: The Saudi Heart Association (SHA) developed this position statement through a structured, multistep process that included a comprehensive literature review and two expert panel meetings. Recommendations were formulated based on current evidence, expert …

Prevalence And Characteristics Of Prescription Errors In Community Pharmacies In Mbarara City, South Western Uganda, Tadele Mekuriya Yadesa, Ashaba Comfort, Komukyeya Esther Marvel, Namakula Angela, Tikolu Hope Nancy, Narayana Goruntla, Sarad Pawar Naik Bukke, Bontu Aschale Abebe, Efrata Ashuro Shegena

AUIQ Complementary Biological System

A prescription error is a failure in the prescription writing process that results in a wrong instruction about one or more of the standard features of a prescription. Most adverse drug events are preventable through promoting rational drug use; primarily by mitigating the outstanding high burden of prescribing errors. The main aim of this study is to assess the prevalence and characteristics of prescription errors in the community pharmacies in Mbarara, Uganda. A cross-sectional study was conducted in selected community pharmacies in Mbarara City, South Western Uganda. Consecutive sampling of all prescriptions availed at the selected pharmacies was conducted until …

The Taiwanese Way To Ai Governance: Draft Basic Law On Artificial Intelligence And Future Regulatory Strategies

Washington International Law Journal

Abstract: Despite Taiwan’s significant contributions to the global artificial intelligence (AI) ecosystem, its role remains underexamined in international AI governance discourse. This Article addresses this gap by analyzing Taiwan’s emerging AI regulatory framework, with particular emphasis on the Draft Basic Law on Artificial Intelligence (the “Draft AI Law”). Situating Taiwan’s approach within the broader global regulatory landscape, the Article compares the Draft AI Law with key international models, including the European Union’s AI Act and the United States’ NIST AI Risk Management Framework, while also drawing on regulatory developments in Japan and South Korea. Rather than providing a clause-by-clause analysis, …

Reviving Novorossiya: Russia’S Invasion Of Ukraine Under International Law

Washington International Law Journal

Abstract: For nearly three years, the Eastern European nation of Ukraine has been entangled in a war it did not instigate, did not desire, but was forced into by its more powerful neighbor, Russia. Since the onset of the war, Russia has faced accusations of widespread atrocities, including severe violations of human rights, international humanitarian law, and breaches of other international norms. Following the inauguration of United States (US) President Donald Trump, there has been a renewed effort to bring both parties to the negotiating table and end the conflict. With the ongoing negotiations, there is no better time to …

Volume 35, Issue 1: Contents

Washington International Law Journal

No abstract provided.

Litigating Workplace Sexual Harassment In China: Practical Challenges & Proposed Solutions

Washington International Law Journal

Abstract: The development of China’s anti-sexual harassment laws and policies over the past few decades has raised the hopes of many. However, the sheer volume of regulations can easily create the false impression that the Chinese legal system is effectively dealing with workplace sexual harassment. Statistics show that the number of lawsuits filed in Chinese courts remains trivial, even though workplace sexual harassment continues to be widespread. This article argues that courts in China misunderstand how to apply important concepts in litigation such as how to define sexual harassment and employer liability. The difficulty of carrying the burden of …

Hybrid Warfare: A Collection Of Scenarios, Adrian Borbély

DRI Press

Hybrid Warfare is nothing new but it has increasingly made the news - even if most of it remains beyond our awareness. Hybrid Warfare gathers all methods through which countries wage war against each other beyond traditional military, diplomatic and economic battlefields (cyber attacks, disinformation, transnational organized crime, appropriation of natural resources, lawfare, corruption, etc.). Such below-the-surface foreign aggressions are not limited to localized regions where armed forces shoot at each other trying to take each other’s positions. In hybrid warfare, society as a whole is the battlefield. In other words, hybrid warfare is not the concern of a few, …