Digital Commons Network^™

Multi-Institutional Normal Tissue Complication Probability (Ntcp) Prediction Model For Mandibular Osteoradionecrosis: Results From The Predmorn Study, Laia Humbert-Vidan, Christian R Hansen, Steven Petit, Carles Muñoz-Montplet, Katrina Hueniken, Abdallah S R Mohamed, Deborah P Saunders, Vinod Patel, Gerda M Verduijn, Wilma D Heemsbergen, Arjen Van Der Schaaf, Max Witjes, Suzanne P M De Vette, Mohammad Moharrami, Abdul A Khan, Jordi Marruecos Querol, Irene Oliveras Cancio, Mike Oliver, Peter Reich, Stacey A Santi, Andrew G Pearce, Stephen Y Lai, Andrew P King, Ali Hosni, Andrew J Hope, Erin E Watson, Johannes A Langendijk, Jørgen Johansen, Amy C Moreno, Clifton D Fuller, Lisanne V Van Dijk, Teresa Guerrero Urbano

Faculty, Staff and Student Publications

Purpose: Mandibular osteoradionecrosis (ORN) is a severe late complication affecting patients with head and neck cancer (HNC) treated with radiation therapy (RT) that significantly impacts patients' quality of life and can require costly interventions. Although radiation dose is a key factor, other clinical and demographic risk factors also influence ORN development. Previous predictive models have primarily been single-institutional, limiting their generalizability. In this first analysis from the PREDMORN Consortium, we have aimed to reproduce existing statistical association and modeling analyses on the largest and most diverse mandibular ORN cohort worldwide to allow comparison with previous studies.

Methods and materials: This …

Comparison Of Surgery And Medicine On The Impact Of Diverticulitis (Cosmid) Trial: A Protocol For A Pragmatic Randomised Study Of Diverticulitis Treatment In The Usa, Mariam N Hantouli, Robert H Schmicker, Janice E Tufte, Fadwa G Ali, Robert D Bennett, Jessica N Cohan, Bryan A Comstock, Thomas Curran, Giana H Davidson, Samuel Eisenstein, Katherine N Fischkoff, Fergal J Fleming, Irena Gribovskaja-Rupp, Mehraneh Dorna Jafari, Larry G Kessler, Mukta K Krane, Sarah O Lawrence, James T Mccormick, Stefanos G Millas, Arden M Morris, Kelsey M Pullar, Caroline E Reinke, Julia T Saraidaridis, Vlad V Simianu, Suzanne P Watkins, Nicole B White, Elizabeth C Wick, Nicole Wieghard, David R Flum, Thomas E Read

Faculty, Staff and Student Publications

Introduction: Each year, millions of people experience recurrent diverticulitis episodes. Elective sigmoid colon resection reduces the risk of recurrence, but The American Society of Colon and Rectal Surgeons recommends individualising surgical decisions based on the impact of the condition on a patient's quality of life (QoL). However, no threshold for QoL impairment has been established to guide decision-making, and evidence comparing elective colectomy with medical management in terms of QoL limitation is limited. To address these gaps and to guide treatment decision-making, we designed the Comparison of Surgery and Medicine on the Impact of Diverticulitis (COSMID) trial.The COSMID trial is …

Disparities In Cardiovascular Disease Burden Among Black And Hispanic Survivors Of Adolescent And Young Adult (Aya) Cancer, Tori Tonn, Maanvi Thawani, Margaret Mazer, Greg Aune, Debra Eshelman-Kent, Karen Albritton, Efstratios Koutroumpakis, Michael E Roth, Michelle A T Hildebrandt

Faculty, Staff and Student Publications

Background: Despite significant improvements in long-term survival outcomes for adolescents and young adults (AYAs) with cancer, common treatment regimens often pose substantial risks to the cardiovascular health of this survivor population. Differences in cardiovascular events by race/ethnicity and genetic ancestry within this at risk population remain unclear.

Methods: In this study, we investigated adverse cardiovascular outcomes in a diverse population of AYA cancer survivors (n = 346) treated at MD Anderson Cancer Center for Hodgkin lymphoma and sarcoma. Analysis was conducted by self-identified race/ethnicity and by genetic ancestry.

Results: Black and Hispanic survivors demonstrated the greatest burden of poor …

Combinatorial Synthesis Of Protein-Polymer Conjugates By Post-Polymerization Modification Of Poly(Pentafluorophenyl Acrylate)S, Emily W. Kish, Thatcher M. Lee, Alexis M. Ziemba, Ama Boamah, Bianca Figueroa, Margherita Piccardi, Carey E. Dougan, Sarah J. Moore, Maren E. Buck

Chemistry: Faculty Publications

Combinatorial methods for preparing polymeric biomaterials enable the rapid identification of materials useful for many applications in science, medicine, and engineering. In the work described here, we demonstrate that side-chain reactive polymers can be used as templates for the rapid preparation of a small library of diversely functionalized protein–polymer conjugates. The activated ester polymer poly(pentafluorophenyl acrylate) (PPFPA) was modified postpolymerization with substoichiometric equivalents of three hydrophilic primary amines to yield a library of amphiphilic, side-chain reactive copolymers. These copolymers were then conjugated to two receptor-targeting proteins, holotransferrin (hTF) and an engineered fibronectin-based protein (Fn3), through amine-activated ester coupling. We investigated …

Women In The Workplace In 2025: Utahns' Awareness, Understanding, And Attitudes, Susan R. Madsen, April Townsend

Marketing and Strategy Faculty Publications

During the fall of 2023, Utah Women & Leadership Project (UWLP) researchers conducted a statewide study to establish a baseline for public perceptions related to the awareness, understanding, and attitudes about challenges that Utah women and girls face. In early 2024, we published 20 short research summaries¹ that shared the results of this comprehensive study (see Nos. 9–28). Next, in the fall of 2024, we administered this survey, with slight changes, around the state of Utah for the second time. Six comprehensive research white papers were then published on the results (see Nos. 11, 12, 13, 14, 16, and …

Longitudinal Observation Of Children With Achondroplasia: Findings From A Global Natural History Study (Achieve), Ciara Mcdonnell, Hanne Buciek Hove, Melita Irving, Klane K White, Cesar G Fontecha, Janet M Legare, Wolfgang Högler, Daniel G Hoernschemeyer, Dirk Schnabel, Sheila Unger, Carlos Alberto Bacino, Paul Hofman, Yongguo Yu, Huamei Ma, Chunxiu Gong, Xiaoping Luo, T Andrew Burrow, Geneviève Baujat, Stefano Mora, Melissa Fiscaletti, Carol Zhao, Michael A Makara, Aimee D Shu, Ravi Savarirayan

Faculty, Staff and Students Publications

Introduction: The ACHieve study assessed growth velocity, body proportionality, and clinical events in children with achondroplasia not receiving growth-promoting therapy.

Methods: ACHieve was a global, longitudinal, prospective, observational study. Children ≤8 years old with achondroplasia were enrolled and evaluated every 6 months for anthropometric parameters and clinical events.

Results: ACHieve enrolled 259 children in 15 countries, including 83 from China. Median follow-up was 21 months; median age of diagnosis was approximately 52 weeks in China and 2 weeks elsewhere. Growth parameters were similar regardless of region. Mean annualized growth velocity was 9.3 cm/year for males and 10.4 cm/year for females …

Automated Database Selection Via Empirical Validation And Cost-Adjusted Scoring, Nazar Ahamed, Navakanth Talluri

Defensive Publications Series

Selecting a database service can be challenging when decisions rely on static information or generalized benchmarks, which may not align with an application's specific runtime performance needs, potentially leading to implementation risks. A system can provide automated, performance-validated database recommendations. The system can translate a user's non-functional requirements into a profile used to programmatically provision temporary test environments for candidate databases. A workload generator can then simulate a user's specific application load within these environments, which may allow the system to harvest real-time performance and cost metrics. The collected empirical data can be processed by a scoring algorithm to calculate …

End Point–Based Threshold For The Ambulatory Arterial Stiffness Index, Yi-Bang Cheng, De-Wei An, Dong-Yan Zhang, Yu-Ling Yu, Jesus D. Melgarejo, José Boggia, Dries S. Martens, Tine W. Hansen, Kei Asayama, Gladys E. Maestre

School of Medicine Publications

Background: The ambulatory arterial stiffness index (AASI) is increasingly used in clinical research and practice. This individual-participant meta-analysis aims to consolidate the prognostic accuracy of AASI in the general population and to derive an end point-based AASI risk threshold.

Methods: In 12 558 individuals enrolled in 14 population studies (48.8% women; mean age, 59.3 years), AASI was derived by regressing 24-hour diastolic on systolic blood pressure (mm Hg/mm Hg). Using Cox regression, the risk-carrying AASI threshold was established by examining stepwise increasing AASI levels and by determining the AASI level, yielding a 10-year risk similar to an office systolic pressure …

Classification Of Venomous Snakes In Thailand Based On The Melting Temperature Specificity Of Target Genes Using Sybr Green Real-Time Pcr, Sunutcha Suntrarachun, Tanapong Tawan, Lawan Chanhome

The Thai Journal of Veterinary Medicine

The SYBR Green real-time PCR was developed for the rapid and accurate classification of major venomous snakes in Thailand. The method relies on melting temperature (Tm) discrimination of target genes from mitochondrial ribosomes. Short single-stranded primers were designed to specifically amplify synthetic DNA of venomous snakes in a single reaction (singleplex), producing distinct melting peaks. Neurotoxic snakes such as cobras (Naja spp.), king cobra (Ophiophagus hannah) and kraits (Bungarus spp.) exhibited melting peaks ranging from 81.00 to 86.00°C, whereas hematotoxic snakes, including the Siamese Russell's viper (Daboia siamensis), Malayan pit viper (Calloselasma rhodostoma …

Analysis Of Lake Toba Ecoliteracy In High School Students, Jesika Aurelia Sianipar, B Manurung, Martina Asiati Napitupulu, Abdul Hakim Daulae

Jurnal Pendidikan Sains

The Lake Toba ecosystem is currently experiencing increasingly worsening quality degradation, so that instilling environmental awareness through ecoliteracy has become urgent in the world of education. This study aims to measure the ecoliteracy abilities of students at High School 1 Ajibata and High School 2 Balige by reviewing three main aspects: cognitive, affective, and behavioral. Additionally, it will analyze the differences in ecoliteracy levels between the two schools. The type of research used is ex post facto with a quantitative approach. Data were collected through test instruments for the cognitive aspect and questionnaires for the affective and behavioral aspects. The …

The Effectiveness Of Economic And Social Rights In Rural Morocco, Safaa Sniny

Revue Marocaine de Droit, d'Economie et de Gestion (Moroccan Journal of Law, Economics and Management)

The effectiveness of economic and social rights in rural areas remains a major challenge in Morocco. This study assesses everyday inequalities by examining the actual enjoyment of fundamental rights in two regions—Marrakech–Tensift–Al Haouz and Taza–Al Hoceima–Taounate—using a mixed‑methods design that combines quantitative and qualitative data. The findings indicate insufficient effectiveness across key indicators, including access to education, healthcare, and basic infrastructure, with particularly adverse outcomes for women and the poorest populations.

The Enduring Courage And Vision Of Franklin Delano Roosevelt, Emilio F. Iodice

The Journal of Values-Based Leadership

Franklin Delano Roosevelt (FDR) led during the most turbulent period in modern American history, facing not one but two existential crises: the Great Depression and World War II. His thirteen-year presidency was a lesson in courage, vision, and leadership, showing that true liberty relies as much on economic security and social justice at home as it does on military victory abroad. Today, as freedom faces both subtle and overt threats worldwide, Roosevelt’s example continues to serve as a vital blueprint for strong democratic governance.

Toward A Contemporary Understanding Of Global Leadership: Relevance Of Diverse Voices, International Collaboration, And New Perspectives, Joseph M. Cervantes, Viet A. Ho, Vui T. Nguyen, Tram N. Le, Minh N.P. Vo

The Journal of Values-Based Leadership

This paper introduces Integral Global Attunement (IGA) as a transformative paradigm in global leadership, emerging in response to the unprecedented shifts catalyzed by theCOVID-19 pandemic. Rooted in the fusion of psychological insight, intercultural consciousness, and ethical stewardship, IGA proposes a fifth wave of leadership—one that transcends transactional strategies to embrace identity, ethics, and relational interconnectedness as central pillars of influence. The writing argues that the current global crises reflect not merely external disruption but an inner dissonance within humanity, calling for a deeper, multi-aware model of leadership. Through the triadic lens of identity (e.g., multicultural integration, visionary consciousness), ethics (e.g., …

The Receptive And Resilient Leader: Thriving In An Era Of Ai And Digital Disruption, Hershey H. Friedman, Nakato Hirakubo, Barbara Jo Lewis

The Journal of Values-Based Leadership

In an Age of Chaos, a term often used to describe the digital AI age, with its explosive growth of information and disruptive technology, businesses face unprecedented turbulence. This paper examines the essential leadership qualities required for success in this environment, arguing that traditional leadership, as seen in the decline of Kodak, Sears, and Blockbuster, struggles to adapt to rapid technological and market shifts. We identify several key competencies for leaders in the digital age: fostering agility, championing an ethical culture, pursuing purpose-driven goals, maintaining technological competency, and genuinely understanding diversity. Perhaps most crucial is receptive leadership, which embodies humility, …

The Effect Of Servant Leadership And Psychological Safety On Employee Commitment And Workplace Engagement, Pierce J. Ippolito, Joshua S. Kay, Kevin J. Hurt

The Journal of Values-Based Leadership

This paper presents a conceptual model of servant leadership, psychological safety, work engagement, and individual commitment. Psychological safety is positioned as a causal factor that provides answers addressing why servant leaders have positive effects on individual commitment and work engagement. The depicted model operates under the consideration that commitment and engagement serve two distinct roles based on the study conducted by Hirschfeld and Feild (2000). Theory-based propositions are developed linking servant leadership and psychological safety to individual commitment and work engagement. Finally, the authors provide a framework that may be utilized for future research.

Pure Leadership Model: A Framework For Leaders Desiring To Lead With An Upright Heart, Matome Liphy Ramalepe

The Journal of Values-Based Leadership

Contemporary organisations face intensifying demands for value-driven decision-making, ethical consistency, and service-oriented leadership. These demands underscore the need for frameworks that integrate character formation with organisational performance. In response to these challenges, the Pure Leadership Model conceptualises leadership as a virtue-centred system in which specific virtues function as the mediating link between leadership styles and core organisational values. The model positions the virtues of meekness, compassion, courage, faithfulness, sincerity, and prudence as central mechanisms through which servant, ethical, and authentic leadership translate into the organisational values of service, accountability, and integrity. Through this virtuous mediation, the model ultimately promotes organisational …

The Core Triplet Theory On Leadership, Sajid Hameed

The Journal of Values-Based Leadership

There are many theories about what makes a leader effective, but no area of research has been studied more than leadership. Traditional models are comprehensive lists of traits; hence, we seldom find a person who possesses them all. One such model is the Core Triplet Theory on Leadership, which simplifies leadership into three core values: Integrity, Empathy, and Vision. These qualities express themselves at three levels: personal, human, and organizational. This theory is a simple, holistic, and pragmatic model to apply, and its adaptability to modern leadership challenges instills confidence. Integrity nurtures trust and ethical consistency at the individual level; …

Winter/Spring 2026

The Journal of Values-Based Leadership

No abstract provided.

A Treasure Hunt: The Interdisciplinary Challenge Of A Digital Humanities Hackathon, Marie Barras, Adélaïde Quenson, Adrien Jeanrenaud, Angela Allemand, Marina Berazategui, Levyn Bürki, Michel Capot, Simon Gabay, Vestin Hategekimana, Pauline Jacsont, Bokar Lamine N'Diaye, Elina Leblanc, Clara May, Anne-Laure Oberson, Margherita Parigini, Lara Pitteloud, Fassaleh Taal, Cédric Viaccoz

Artl@s Bulletin

Abstract: This article tells the story of an interdisciplinary hackathon emphasizing exploration, collaboration, and creative engagement with globalization-related cultural datasets. Participants worked in teams to produce research posters, which were then presented at the opening of the international conference Image Deluge & Globalization in Geneva. The article discusses three projects: one on 19th-century Spanish chapbooks using topic modeling and network analysis; another on leopard motifs in print imagery; and a third on olfactory heritage. The hackathon highlighted both the potential and the limitations of working with digital cultural data, offering insights into interdisciplinary methods.

Résumé: Cet article raconte un hackathon …

Queens, Pearls And Spirochaetes, Radu Suciu

Artl@s Bulletin

Abstract: In December 2019, the New Zealand AIDS Foundation (now the Burnett Foundation) released a public health campaign raising awareness about the increasing rates of syphilis infections in New Zealand. The campaign consisted of photographs that contrasted contemporary backgrounds of bars and nightclubs with actors wearing theatrical costumes akin to the Elizabethan period. This reinforced the perceived idea that syphilis was a disease resurging from the distant past. This paper discusses one of the campaign’s most iconic portraits by analysing its shared cultural, artistic, and medical references (explicit or implicit) and their shifting meanings through time.

Résumé: En décembre 2019, …

Food Insecurity. A Factor In Criminal Behavior?, Jerrod Brown, Jeremiah Schimp, Leanne Skehan, Janina Cich

Nutritional Neurocriminology Today

This article examines how food insecurity and limited access to nutritionally adequate foods impair cognitive function, emotional regulation, decision-making, and impulse control. Emerging research purports that individuals experiencing food insecurity face increased risks of mental and physical health problems, violent behavior, delinquency, heightened childhood vulnerability, and criminal justice involvement across the lifespan. The article advocates for increased awareness, routine screening, and specialized training for professionals in mental health, social services, and the criminal justice system to address food insecurity, thereby supporting long-term policy and community-level strategies that reduce criminal behavior and improve outcomes for vulnerable populations.

Legendary Houses: Trademarks, Transformation, And Ballroom Culture, Elizabeth L. Rosenblatt

Akron Law Review

No abstract provided.

Assessing Patent Pledges: A Case Study In The Vaccine And Biopharma Space, Ana Santos Rutschman

Akron Law Review

No abstract provided.

Irish Radio's Digital Transition: Back To The Future, Kenneth Murphy

Irish Communication Review

The current paper critically interrogates the predictions made by experts in Irish radio in 2017 and analyses how they align with the reality of the evolved radio landscape in the Republic of Ireland in 2025. In doing so, the article examines developments in radio media in Ireland from 2017 to 2025, situating this national case study within broader European patterns of technological transition and media evolution, and looking ahead to likely developments in the near future. Drawing on longitudinal data from industry analyses, media coverage and regulatory frameworks, it investigates the persistence of FM broadcasting alongside the development of digital …

Beyond Broadcasting: Irish Radio And The Convergent Mediascape Of The 21st Century, Daithí Mcmahon

Irish Communication Review

As we reflect on one hundred years of broadcast radio in Ireland, we are reminded of the resilience required to remain a prominent fixture in what has become a highly congested digital mediascape. The Irish radio industry’s survival and continued success has been made possible, paradoxically, by remaining true to its origins as a linear, aural medium - while at the same time adapting to become a modern, digitally convergent one. Over the last twenty-five years, Irish radio has continued to serve as a live, spontaneous and trustworthy medium, providing an ever-present voice in Irish people’s lives at home and …

Who You Gonna Call? Talk Radio As Therapy And As A Marker Of Social Change In Ireland, Finola Doyle O'Neill

Irish Communication Review

In the Irish context, the radio talk show has long constituted a distinctive cultural institution, evolving from early programmes such as Dear Frankie, The Gay Byrne Show, The Ryan Line, and Liveline into a significant public forum for the expression of personal narratives, collective opinion, and emotional resonance (O’Sullivan, 2005). Over time, this genre has undergone a notable transformation—from functioning as a secular analogue to the Catholic confessional to becoming an increasingly therapeutic outlet for listeners. This evolution is emblematic of wider sociocultural shifts in Ireland, particularly the waning influence of institutional religion (Inglis, 2000) and the disintegration of traditional …

The Unscripting Of Broadcasting In Postwar Ireland, Eileen Morgan-Zayachek

Irish Communication Review

This article builds on existing histories of Irish broadcasting by examining the contexts and implementation of postwar reforms initiated by Fianna Fáil politician, Erskine Hamilton Childers. The lifting of script submission requirements and promotion of open debate extended Childers’ efforts to modernize Ireland’s infrastructure and promote civic engagement. Childers viewed Irish radio as a platform for cultivating critical thinking, public debate, and understanding of state institutions—assets he believed Irish citizens needed to compete in the global economy. The article reviews the repressive practices of the early broadcasting service that sought to avoid all controversial content. It also traces a throughline …

Acute Stemi In A Young Adult On Therapeutic Anticoagulation Following Diclofenac Use, Naeem Hasanfatta, Naveed Ahmed, Debabrata Dash

Journal of the Saudi Heart Association

Background: Acute coronary syndrome (ACS) in young adults is uncommon. The case of a 34-year-old male, post mechanical mitral valve replacement (MVR), who developed anterior ST-elevation myocardial infarction (STEMI) despite therapeutic anticoagulation (INR 3.17), shortly after the initiation of diclofenac, highlights an important clinical scenario.

Case Presentation: The patient presented with atypical upper back pain and was diagnosed with anterior STEMI. Coronary angiography revealed a 100% thrombotic occlusion in the mid left anterior descending (LAD) artery. Percutaneous transluminal coronary angioplasty (PTCA) was successfully performed. Importantly, the patient had no history of hypercoagulable states or atherosclerosis and had been compliant with …

Optimized Resnet-18 Architecture For Multi-Class Oral Diseases Classification, Ahmed Ahmed

Karbala International Journal of Modern Science

In recent years, the classification of oral diseases has gained significant attention due to its influence on public health and the necessity for early and accurate diagnosis. Traditional diagnosis depends on manual clinical assessment, which can be slow and subjective. An optimized and subsequently quantized model is required to provide a faster and more consistent diagnostic support tool. This paper proposes an optimized ResNet-18 architecture for the classification of six oral diseases. The optimization process is based on removing the Rectified Linear Unit (ReLU), Batch Normalization (BN), and convolutional layers from the base ResNet-18 blocks that contain 128 filters. This …

Sperm-Associated Antigen 6 (Spag6) As A Potential Marker Of Sperm Function In Diagnosing Male Infertility, Ibtisam A. Al-Ali,, Kawkab A. Alsaadi

Karbala International Journal of Modern Science

Background: While male infertility has become a significant global health concern, conventional analysis of semen has not made progress in the detection of contraindicated molecular biomarkers, such as sperm-associated antigen 6 (SPAG6), which is a protein involved in axonemal structure and flagellar motility.

Hypothesis: Expression of SPAG6 correlates with sperm motility and structural integrity. This means that its dysregulation may serve as a molecular indicator of impaired sperm performance.

Methods: A comprehensive review of recent studies was conducted with a focus on SPAG6’s molecular characteristics, expression patterns in normal versus abnormal spermatozoa, and the role it plays in motility-related …