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Class Notes

DePaul Magazine

From promotions to performances, see the latest accomplishments by DePaul alumni across class years and generations. Plus, read alumni spotlight profiles of Rudy Hodgson (CMN ’22), a pro hockey announcer, and Rania Elalej (BUS ’20), an international hotel operations specialist.

Molecular Determinant Of Low-Voltage Dependence Of Human Nav1.7 Inactivation Revealed By Efficacy-Based Nav1.7 Selective Inhibitor, Fang Zhao, Chuchu Xi, Jie Li, Kerui Ren, Qinglian Tang, Huaduan Liang, Shilong Yang, Michael X Zhu, Zhengyu Cao

Faculty, Staff and Student Publications

Nav1.7 is a voltage-gated sodium channel (VGSC) subtype predominantly expressed in sensory neurons, amplifying threshold currents. Here, we identify that Uvarigranol D (UGD) suppresses human (h) Nav1.7 with a much greater maximal inhibition than other VGSC subtypes, despite having similar apparent affinities. We demonstrate that Thr1398 determines the greater inhibitory efficacy of UGD, the leftward shift in voltage-dependence and faster inactivation kinetics of hNav1.7. UGD binds to the inactivated state, with Gln360, Ile394, Lys1395, Phe1737, and Tyr1744 being critically involved. Moreover, while UGD suppresses action potentials in both rat dorsal root ganglion neurons and human induced pluripotent stem cell-derived cardiomyocytes, …

Decitabine-Cedazuridine In Patients With Mds And Tp53 Mutations, Samuel Urrutia, Koji Sasaki, Alex Bataller, Hagop Kantarjian, Guillermo Montalban-Bravo, James Mccloskey, Elizabeth A Griffiths, Karen Yee, Amer Zeidan, Michael Savona, Aram Oganesian, Yuri Sano, Harold N Keer, Guillermo Garcia-Manero

Faculty, Staff and Student Publications

No abstract provided.

Channel Gating In Bacteriorhodopsin-Like Channelrhodopsins With Contrasting K+ And Na+ Selectivity, Oleg A Sineshchekov, Elena G Govorunova, Hai Li, Yumei Wang, John L Spudich

Faculty, Staff and Student Publications

Two closely homologous channelrhodopsins from Hyphochytrium catenoides, known as HcKCR1 (kalium channelrhodopsin 1) and HcCCR (cation channelrhodopsin), exhibit >100 times different K+/Na+ relative permeabilities and are emerging optogenetic tools for controlling neurons and cardiomyocytes. Key residue motifs and trimeric organization relate them structurally to bacteriorhodopsin-like cation channelrhodopsins (BCCRs). Here, we demonstrate that they utilize a specific gating mechanism previously suggested for the earlier-discovered BCCR from cryptophytes. Using a comparative analysis of transient absorption changes and photocurrents under single-turnover conditions, we identified an early, far-UV-absorbing photocycle intermediate that precedes channel opening in wild-type HcKCR1 and HcCCR. The UV-absorbing product is a …

Development And Evaluation Of Lipid Nanoparticle-Encapsulated Dna Vaccines For Avian Influenza In Chickens, Sushmita Kumari

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Avian influenza virus (AIV) remains a major challenge for global poultry health, food production, and agricultural economies. Both low-pathogenic (LPAIV) and highly pathogenic (HPAIV) strains continue to circulate and evolve, creating an ongoing need for vaccines that can be updated quickly and provide broad protection. Although DNA vaccines offer a safe and flexible approach to rapidly incorporate new antigens, their use in poultry has been limited by poor delivery efficiency and the vulnerability of naked DNA to degradation. Lipid nanoparticles (LNPs), which have proven highly effective for mRNA delivery, offer a promising solution, yet their potential for DNA delivery in …

Associations Between Overt And Subclinical Hypothyroidism In Pregnancy And Adverse Maternal And Neonatal Outcomes: A Cohort Study, Rahma Al Kindi, Noof Al Ghammari, Amina Al Malki, Aida Al Ismaili, Hana Al Sumri

Sultan Qaboos University Medical Journal

Objectives: This study aimed to determine associations between hypothyroidism during pregnancy and selected maternal and neonatal outcomes. Methods: A retrospective, cohort study was conducted between January 2018 and December 2020 at the two main tertiary hospitals in Muscat, Oman. The study included 408 Omani pregnant women aged 18–45 years. Participants were divided into two groups: those diagnosed with overt or subclinical hypothyroidism (n = 201; exposed group) and those with normal thyroid function (n = 207; unexposed group), matched for relevant variables. Data were collected from electronic medical records to assess maternal and neonatal outcomes. Results: Most exposed women …

2026-02-10 Minutes, Morehead State University. Staff Congress.

Staff Congress Records

Staff Congress meeting minutes from February 10, 2026.

Toward Transformative Social Protection: Integrating Economic Empowerment And Addressing Graduation Challenges In Egypt’S Takaful And Karama Program, Mennatalla Ahmed Zayed

Theses and Dissertations

This study investigates how Egypt's Takaful and Karama Program (TKP) can enhance long-term poverty reduction and program sustainability through the inclusion of economicempowerment interventions. Based on the frameworks of Social Risk Management 2.0 and Transformative Social Protection, the study places Egypt's experience in the context of international discussions about conditional cash transfers, multidimensional poverty, and graduation models. The study uses a qualitative methodology, conducting semi-structured interviews with academics, civil society experts, and policymakers. The interviews' findings are supported by content analysis of policy documents and impact evaluations on TKP and Forsa. According to the research analysis, cash transfers help alleviate …

Ai Scribe Use In Residency Training: A Call For Specialty Society Guidance In Graduate Medical Education, Julia A. Giordano, Elizabeth Jones

Department of Dermatology and Cutaneous Biology Faculty Papers

Artificial intelligence (AI) is increasingly used for documentation purposes in clinical practice, yet guidance for resident use is limited. Given the substantial documentation burden on medical trainees, AI-powered scribing tools may offer benefits, but their integration into residency training raises educational, supervisory, and patient safety considerations. This study aimed to assess the availability of resident-specific guidance on AI scribe use from major medical and specialty organizations and to summarize current evidence on AI scribes in residency. We reviewed five major medical and specialty society websites (AAD, AMA, ACGME, AAMC, ABMS) via website searches and direct emails and conducted a PubMed …

Leveraging Clinical Sleep Data Across Multiple Pediatric Cohorts For Insights Into Neurodevelopment: The Retrospective Analysis Of Sleep In Pediatric (Rasp) Cohorts Study, Naihua N Gong, Aditya Mahat, Samya Ahmad, Daniel Glaze, Mirjana Maletic-Savatic, Matthew Mcginley, Anne Marie Morse, Alcibiades J Rodriguez, Audrey Thurm, Susan Redline, Kiran Maski, Peter Davis, Shaun Purcell, Ashura Buckley

Faculty, Staff and Students Publications

Sleep disturbances are prominent across neurodevelopmental disorders (NDDs) and may reflect specific abnormalities in brain development and function. Overnight polysomnography (PSG) allows for detailed investigation of sleep architecture, offering a unique window into neurocircuit function. Analysis of existing pediatric PSGs from clinical studies could enhance the availability of sleep studies in pediatric patients with NDDs towards a better understanding of mechanisms underlying abnormal development in NDDs. Here, we introduce and characterize a retrospective collection of 1527 clinical pediatric overnight PSGs across five different sites. We first developed an automated stager trained on independent pediatric sleep data, which yielded better performance …

Hyperdensity On Head Ct—An Imaging Review, Ramsis Benjamin, Christian Menard, Erik Larson

School of Medicine Publications

The 3D images derived from non-contrast Computed Tomography (NCCT) scans provide a glimpse into the intra- and extracranial structures, based on the ability of electromagnetic X-rays to penetrate through various tissue densities. The gray matter, for example, possesses a higher density than the white matter, absorbs more X-rays, allows less penetration (attenuation), and thus has larger Hounsfield units (HU), the mathematical value of attenuation coefficient. The CT scanner’s wide availability and ease of use allow for quick assessment of acute neurosurgical abnormalities, such as hemorrhages, mass effect, hydrocephalus, and traumatic injuries. An attenuation value of +60 to +90 HU generally …

Discovery Of Horsfieldia Macrothyrsa Bioactives With Cytotoxic Effects On Breast Cancer Cells Through In Vitro And Docking Analyses, Megawati Megawati, Akhmad Darmawan, Agus Budiawan Naro Putra, Kartika Dyah Palupi, Marissa Angelina, Ahmad Randy, Siska Andrina Kusumastuti, Faris Hermawan, Sumi Hudiyono

Karbala International Journal of Modern Science

This study investigated the phytochemical constituents and biological activities of Horsfieldia macrothyrsa leaves to identify their bioactive compounds. Methanol extracts were fractionated using n-hexane and ethyl acetate, followed by silica gel column chromatography with a stepwise polarity gradient. From 100 g of powdered leaves, three major    compounds were successfully isolated from the ethyl acetate fraction: 1-(2,4,6-trihydroxyphenyl)dodecan-1-one (1), sesamin (2), and β-sitosterol (3). Their chemical structures were confirmed using UV, IR, LC–MS/MS, and NMR  spectroscopy. Biological activities of the fractions and isolates were evaluated through DPPH antioxidant assays, α-glucosidase inhibition for antidiabetic activity, MTT …

Data Management Plans For Grant Proposals, Rubab Shahzad

Day Family Research Lab Workshop Series

Fundamentals of research data management and how to create effective Data Management Plans (DMPs) and Data Management Sharing Plans (DMSP)

Inside Aurora Sinai Medical Center, 2004 January, Advocate Health - Midwest

Historical Documents - Combined

Aurora Sinai Medical Center, Milwaukee, WI: Internal employee newsletter with workplace anniversaries, news, and events.

Inside Aurora Sinai Medical Center, 2004 February, Advocate Health - Midwest

Historical Documents - Combined

Aurora Sinai Medical Center, Milwaukee, WI: Internal employee newsletter with workplace anniversaries, news, and events.

Inside Aurora Sinai Medical Center, 2004 March, Advocate Health - Midwest

Historical Documents - Combined

Aurora Sinai Medical Center, Milwaukee, WI: Internal employee newsletter with workplace anniversaries, news, and events. This issue introduces the Planetree plan for Aurora hospitals.

Inside Aurora Sinai Medical Center, 2004 April, Advocate Health - Midwest

Historical Documents - Combined

Aurora Sinai Medical Center, Milwaukee, WI: Internal employee newsletter with workplace anniversaries, news, and events.

Inside Aurora Sinai Medical Center, 2004 May, Advocate Health - Midwest

Historical Documents - Combined

Aurora Sinai Medical Center, Milwaukee, WI: Internal employee newsletter with workplace anniversaries, news, and events. This issue has a feature on the NICU.

Inside Aurora Sinai Medical Center, 2004 June, Advocate Health - Midwest

Historical Documents - Combined

Aurora Sinai Medical Center, Milwaukee, WI: Internal employee newsletter with workplace anniversaries, news, and events.

Inside Aurora Sinai Medical Center, 2004 July, Advocate Health - Midwest

Historical Documents - Combined

Aurora Sinai Medical Center, Milwaukee, WI: Internal employee newsletter with workplace anniversaries, news, and events.

Inside Aurora Sinai Medical Center, 2004 August, Advocate Health - Midwest

Historical Documents - Combined

Aurora Sinai Medical Center, Milwaukee, WI: Internal employee newsletter with workplace anniversaries, news, and events.

Inside Aurora Sinai Medical Center, 2004 September, Advocate Health - Midwest

Historical Documents - Combined

Aurora Sinai Medical Center, Milwaukee, WI: Internal employee newsletter with workplace anniversaries, news, and events.

Inside Aurora Sinai Medical Center, 2004 October, Advocate Health - Midwest

Historical Documents - Combined

Aurora Sinai Medical Center, Milwaukee, WI: Internal employee newsletter with workplace anniversaries, news, and events.

This is the last issue of this newsletter with this title. It continues as Aurora Sinai Exchange.

Inside Aurora Sinai Medical Center, 2003 January, Advocate Health - Midwest

Historical Documents - Combined

Aurora Sinai Medical Center, Milwaukee, WI: Internal employee newsletter with workplace anniversaries, news, and events.

Inside Aurora Sinai Medical Center, 2003 February, Advocate Health - Midwest

Historical Documents - Combined

Aurora Sinai Medical Center, Milwaukee, WI: Internal employee newsletter with workplace anniversaries, news, and events.

Inside Aurora Sinai Medical Center, 2003 March, Advocate Health - Midwest

Historical Documents - Combined

Aurora Sinai Medical Center, Milwaukee, WI: Internal employee newsletter with workplace anniversaries, news, and events.

Inside Aurora Sinai Medical Center, 2003 April, Advocate Health - Midwest

Historical Documents - Combined

Aurora Sinai Medical Center, Milwaukee, WI: Internal employee newsletter with workplace anniversaries, news, and events.

Inside Aurora Sinai Medical Center, 2003 May, Advocate Health - Midwest

Historical Documents - Combined

Aurora Sinai Medical Center, Milwaukee, WI: Internal employee newsletter with workplace anniversaries, news, and events.

Inside Aurora Sinai Medical Center, 2003 June, Advocate Health - Midwest

Historical Documents - Combined

Aurora Sinai Medical Center, Milwaukee, WI: Internal employee newsletter with workplace anniversaries, news, and events.

Inside Aurora Sinai Medical Center, 2003 July, Advocate Health - Midwest

Historical Documents - Combined

Aurora Sinai Medical Center, Milwaukee, WI: Internal employee newsletter with workplace anniversaries, news, and events.