Digital Commons Network^™

Heme And Hemozoin Induce Platelet Cell Death Through Upr-Induced Apoptosis And Ferroptosis In Vivax Malaria, Milena Tavares Gomes, Robert A Campbell, Et Al.

2020-Current year OA Pubs

Malaria is a highly prevalent infectious disease caused by Plasmodium parasites. Plasmodium intraerythrocytic replication leads to hemolysis-driven intermittent febrile crises in patients. In addition, the lysis of unparasitized red blood cells contributes to anemia and endotoxemia. Because thrombocytopenia is an important feature of vivax and severe falciparum malaria, we hypothesized that increased hemolysis in malaria contributes to severe thrombocytopenia by releasing endogenous and parasite toxins (ie, heme and hemozoin) capable of inducing programmed cell death in platelets. Using complementary biochemical, ultrastructural, pharmacological, and molecular approaches, we examined response to stress and cell death pathways that were elevated in the transcriptome …

Outcomes Following Matched Sibling Donor Transplantation For Severe Combined Immunodeficiency: A Report From The Pidtc, Ahmad Rayes, Jeffrey J Bednarski, Et Al.

2020-Current year OA Pubs

The Primary Immune Deficiency Treatment Consortium performed a retrospective analysis of 133 patients with severe combined immunodeficiency (SCID) receiving matched sibling donor (MSD) hematopoietic cell transplantation (HCT) between 1980 and 2023 at 30 North American institutions. In this largest cohort of MSD outcomes in patients with SCID to date, we examined the impact of conditioning regimen and graft-versus-host disease (GVHD) prophylaxis on survival and immune recovery. Outcomes after MSD HCT for SCID were excellent. Patients without an active infection or failure to thrive (FTT) at the time of HCT had 5-year overall survival superior to those with infection or FTT. …

Spartan Daily, February 10, 2026, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2026

Volume 166, Issue 8

Derivation And External Validation Of A Venous Thromboembolism Risk Prediction Model In Asparaginase-Treated All, Daniela R Anderson, Kristen Sanfilippo, Et Al.

2020-Current year OA Pubs

The incidence of venous thromboembolism (VTE) in patients with acute lymphoblastic leukemia (ALL) receiving asparaginase-based induction is high despite primary thromboprophylaxis. Our aim was to derive and externally validate a VTE risk prediction model in patients with ALL receiving asparaginase-based induction. We conducted a multicenter retrospective cohort study of patients (aged ≥18 years) with newly diagnosed ALL receiving asparaginase-based induction. The derivation and external validation cohorts included 306 and 94 patients, respectively. Primary outcome was VTE at any site. A cause-specific Cox proportional hazards model stratified by thromboprophylaxis and center was performed to identify VTE risk factors in the derivation …

Emerging Trends And Challenges In International Student Research: A Content Analysis Of Recent Dissertations (2022–2024), Krishna Bista, Oluwasegun Adesola Oladipo, Lin Ge, Tian Qin

Health Care Administration Faculty Research

This study presents a content analysis of 470 doctoral dissertations published between 2022 and 2024, examining emerging trends, theoretical frameworks, and research approaches related to international students. Using a qualitative content analysis approach and descriptive statistics, the study systematically analyzed the dissertations to identify recurring themes and issues. The key themes identified include teaching and learning; academic practices; acculturation and intercultural competence; career development and leadership; experiences and challenges; mobility and policy contexts; social diversity and inclusion; institutional support; and well-being. The findings show a predominant use of qualitative methods, a concentration on U.S.-based contexts, and a strong disciplinary focus …

The Impact Of Collaborative Well-Being Sessions On Senior Nursing Students, Uzo Nwankpa

Creating Healthy Work Environments (CHWE)

Introduction: This quality improvement project assessed the impact of facilitating a wellness session on the confidence and interest of senior nursing students as part of their transition to practice experiences. We explored the role of collaborative wellness activities led by students and their effects on overall wellbeing.

About 60% of U.S. college students show signs of mental health disorders (Lipson et al., 2022). The mental health challenges are rising, making it crucial to address their overall wellbeing. There's a significant correlation between clinical trainees' burnout, depression, and increased risk of suicidal thoughts (Menon et al., 2020). The three core barriers …

We See You! Increased Focus On Implementing Virtual Monitoring, Valerie E. Menter, Brittney L. Williamson

Creating Healthy Work Environments (CHWE)

A quality improvement project was implemented, focused on increasing utilization of the virtual monitoring unit (VMU) to reduce patient falls. For a three-month period, there were 208 patient falls. Fifty-nine and a half percent of these patients met virtual monitoring criteria but did not have it implemented. Review of the electronic health record (EHR) flowsheet discovered challenges for the nurse to effectively identify patients who met criteria, leading to underutilization of this safety resource. Analysis found nurses were implementing VMU based on subjective reasoning instead of objective criteria, leading to inadequate observation of patients and increased falls.

Outcomes: After receiving …

The Impact Of Using Wearable Technology On Caregiver Perceptions Of Health And Well-Being, Jacob W. Poyer, Marilyn Stapleton, Bridget Nettleton, Victoria Mccartney, David Theobald

Creating Healthy Work Environments (CHWE)

This presentation conforms with the conference theme of creating healthy work environments for nurses. Specifically, this presentation will focus on enhancing the professional well-being of caregivers. Davin Healthcare, Inc., a nurse-founded, employee-owned company, offers staffing and managed service provider solutions for healthcare systems. In keeping with a commitment made by Davin Healthcare, Inc. to care for the future of healthcare and its caregivers, and through its commitment to the AACN Standards for Establishing and Sustaining Healthy Work Environments, a goal was adopted to support the health and well-being of its employees.

The short-term and long-term strategies aim to provide the …

Spatial Control Of Myosin Regulatory Light Chain Phosphorylation Modulates Cardiac Thick Filament Mechanosensing, Caterina Squarci, Daniel Koch, Paul Anaya, Kenneth S. Campbell, Thomas Kampourakis

Physiology Faculty Publications

The heart can adapt its performance in response to changing metabolic demands of the rest of the body. A central mechanism intrinsic to the heart is to modulate the function of the cardiac contractile proteins via posttranslational modifications. Although phosphorylation of the cardiac myosin motor-associated regulatory light chain (RLC) by cardiac myosin light chain kinase (cMLCK) has been recognized as a key signaling pathway to increase myocardial contractile function, little is known about its molecular mechanism of action. Here, we show that phosphorylation of RLC is not a stochastic process but a spatially tightly controlled mechanism in the cardiac sarcomere. …

Maternal Work Intensity And Childhood Health: Heterogeneity Over Stages Of Child Development, Kassahun Mamo Geleta

Economics and Management Faculty publications

Over the past six decades, the labor force participation of working mothers in the US has grown significantly. This study is motivated by the growing trend of mothers’ labor force participation and examines the effect of maternal work intensity on child health. It employs the Panel Study of Income Dynamics’ intergenerational survey data and instrumental variable (IV) probit and ordered probit regression techniques. The results show that maternal hours worked has a positive and statistically significant effect on the likelihood of having a healthy childhood, although the estimated magnitude is modest. The fixed effect estimation that accounts for heterogeneity across …

Staff Education On Motivational Interviewing And Culturally Responsive Education To Reduce No-Shows And Appointment Cancellations, Aisha Adigun

Walden Dissertations and Doctoral Studies

No-show and late appointment cancellations remain significant challenges in outpatient psychiatry clinics, negatively impacting continuity of care, clinic efficiency, and patient outcomes. Motivational interviewing (MI) and culturally responsive communication are evidence-based approaches that support patient engagement and understanding, yet they are not consistently incorporated into staff education related to appointment adherence. This project evaluates whether staff education on MI and culturally responsive communication increases staff knowledge and skills in educating patients about no-show and appointment cancellation policies and whether this education contributes to improved appointment attendance. A pre–post intervention design will be used in an outpatient psychiatry clinic. Clinical and …

Impact Of Incentive Policies On Mathematics And Science Teachers’ Retention In Guyana’S Rural Secondary Schools, Verna Adrian

Walden Dissertations and Doctoral Studies

Research on teacher retention in rural areas highlights persistent challenges, including geographic isolation, limited resources, and inadequate support. Studies have shown that financial incentives are critical for sustaining teacher retention, but a gap in the literature exists as to what specific non-financial challenges may also be important in influencing teachers’ long-term commitment. To address the social problem of teacher retention in rural secondary schools in Guyana, this study assessed the effectiveness of incentive policies in retaining teachers across four selected regions facing unique challenges. Data were collected through semi structured interviews and analyzed using thematic analysis. The purpose of this …

Community Reintegration Programs For Successful Reentry For Individuals Deemed Not Guilty By Reason Of Insanity, Joanna Baker

Walden Dissertations and Doctoral Studies

Very little research has been conducted on the institution of community reintegration programs for individuals deemed not guilty by reason of insanity (NGRI). In the United States, each state can determine the path for community reentry with the NGRI population. California has a strategic and supportive reentry program that requires services such as drug testing, individual therapy, and close monitoring. Other states, including North Carolina, do not have a reentry program in place for the NGRI population. No research exists comparing states with conditional release programs and states without these programs. Consistence in community reintegration programs among all states can …

Reasons For Digital Transformation Project Failures Based On U.S. Project Managers’ Lived Experiences, Susan D. Landes

Walden Dissertations and Doctoral Studies

Digital transformation projects have a failure rate of 66% to 84%, costing U.S. companies billions of dollars each year. Organizational leaders need to understand the implications of these costly failures, leading to substantial financial losses. The purpose of this qualitative descriptive phenomenological study was to explore the reasons for digital transformation project failures from the perspective of the lived experiences of U.S. project managers. The conceptual framework consisted of Lewin’s 3-stage change management model, Correani et al.’s digital transformation implementation model, Herzberg’s 2-factor theory of motivation-hygiene, and von Bertalanffy’s systems theory. The participants were 13 U.S. active, certified professional project …

Trauma Coping Mechanisms Among Police In Small Departments, Peter Michael Ungaro

Walden Dissertations and Doctoral Studies

Mental health services are available to police officers, but many do not utilize these resources due to stigma, shame, and fear of job loss. This reluctance often forces officers to handle mental health issues alone, frequently leading to unhealthy coping strategies that negatively impact their well-being and job performance. While advancements in mental health support exist, they primarily serve larger departments, leaving the needs of small departments largely unmet. The foundation of the study was rooted in resilience theory, which holds that the impact of trauma on an individual is determined not by the event itself but by the coping …

Child Welfare Education Partnership Celebrates First Cohort Of Program Graduates, Keith Testa

UNH Today Archive

No abstract provided.

A Framework For Assessing The Trustworthiness Of Scientific Research Findings, Brian A Nosek, David B Allison, Kathleen Hall Jamieson, Marcia Mcnutt, A Beau Nielsen, Susan M Wolf

Children’s Nutrition Research Center Staff Publications

Vigorous debate has erupted over the trustworthiness of scientific research findings in a number of domains. The question "what makes research findings trustworthy?" elicits different answers depending on whether the emphasis is on research integrity and ethics, research methods, transparency, inclusion, assessment and peer review, or scholarly communication. Each provides partial insight. We offer a systems approach that focuses on whether the research is accountable, evaluable, well-formulated, has been evaluated, controls for bias, reduces error, and whether the claims are warranted by the evidence. We tie each of these components to measurable indicators of trustworthiness for evaluating the research itself, …

Performance Of An Automated Sleep Scoring Approach For Actigraphy Data In Children And Adolescents, Pin-Wei Chen, Erica C Jansen, Christopher M Cielo, Ariel A Williamson, Margaret Banker, Michael Kaye, Peter X K Song, Karen E Peterson, Alejandra Cantoral, Martha María Téllez-Rojo, Cathy Goldstein, Khadija Zanna, Akane Sano, Jennette P Moreno, Heidi Kalkwarf, Babette S Zemel, Jonathan A Mitchell

Children’s Nutrition Research Center Staff Publications

Study objectives: GGIR is an R package for processing raw acceleration data to estimate sleep health parameters. We aimed to (1) assess the performance of three sleep algorithms within GGIR against PSG for detecting sleep/wake in clinically referred, typically-developing children (criterion validity); and (2) describe GGIR-derived sleep estimates from typically developing children enrolled in multiple cohort studies (face validity).

Methods: For criterion evaluation, children (8-16 years, N = 30) wore an actigraphy device for one night during in-lab polysomnography with performance assessed using epoch-by-epoch analyses. For face validity evaluation, four community/free living datasets were used: (1) Bone Mineral Accretion in …

Smoldering Multiple Myeloma In The United States: A Population-Based Analysis, Shi-Yi Wang, Rong Wang, Martin Schoen, John H Huber, Eric J Feuer, Jennifer Ruhl, Natalia Neparidze, Xiaomei Ma, Amy J Davidoff, Su-Hsin Chang

2020-Current year OA Pubs

No abstract provided.

Decitabine-Cedazuridine In Patients With Mds And Tp53 Mutations, Samuel Urrutia, Koji Sasaki, Alex Bataller, Hagop Kantarjian, Guillermo Montalban-Bravo, James Mccloskey, Elizabeth A Griffiths, Karen Yee, Amer Zeidan, Michael Savona, Aram Oganesian, Yuri Sano, Harold N Keer, Guillermo Garcia-Manero

2020-Current year OA Pubs

No abstract provided.

The First Companions: Finding Grace In Dispersion, Sickness, And Conflict, Christopher M. Staab

Landas

In his letter “Confirmed in the Charism,” Father General Arturo Sosa SJ invited the Society of Jesus to understand better how “the first companions were able to read the motions of the good Spirit.” This presentation responds to Fr. Sosa’s call by examining how Ignatius and the first companions found grace in their experiences of dispersion, illness, and conflict. These difficult human experiences fill their extant texts and, as such, provide us with the opportunity to discover how they lived their quotidian apostolic work. Dispersion, illness, and conflict were not experiences to be overcome, but rather experiences to be lived …

Myth As A Bridge Between Science And Religion In The Timaeus, Earl A. P. Valdez

Landas

This paper examines the value of myth and mythmaking in Plato’s worldview, focusing on the creation myth in the Timaeus. It argues that myth and mythmaking ultimately connect religion and science by integrating the why and how of reality. Through narration and interpretation, myth legitimizes reality while generating new knowledge and insight. This process reveals how Greek beliefs about themselves and the world were closely intertwined with explanations of how things work. The paper concludes that myths function as bearers of meaning within the classical worldview. This perspective invites renewed reflection on myths and the ways their enduring narratives …

The Tagalog Verb, Rich In Nuance: Samples From The Vocabulario De Lengua Tagala (Sb 1613), Part I, Emmanuel C. Marfori

Landas

This study examines the Vocabvlario de Lengva Tagala (SB 1613) of Tomás Pinpin and Domingo Loag, highlighting its significance for missionary language learning and the study of Tagalog culture. Focusing on thirty Spanish verbs and their 884 Tagalog equivalents, it analyzes active and passive forms and their connections with body parts, space, time, instruments, purposes, and social interactions. These verbs offer glimpses into daily life in southern Luzon, including food production, crafts, health, commerce, travel, conflict, hospitality, beliefs, healing, and communal activities. The analysis demonstrates the vocabulary’s linguistic richness and complexity while revealing cultural traces of both Tagalog communities and …

Academic Senate - Agenda, 02/10/2026, Academic Senate

Academic Senate Agendas

No abstract provided.

Addressing Staff Nurses’ Work-Related Stress With Peer-Led Interventions, Stacy Horowitz

Creating Healthy Work Environments (CHWE)

Background: The nursing staff in the behavioral health division identified high levels of work-related stress (WRS) in a hospital-wide learning needs assessment (NLNA) and furthermore suggested that the reduction of WRS was the number one priority that needed to be addressed. It is widely known that WRS has implications for nursing staffs' productivity, retention, safety and over-all wellbeing. Provision 5 of the Code of Ethics for Nurses notes that “The nurse owes the same duties to self as to others, including the responsibility to promote health and safety...” and Provision 6 requires that “The nurse, through individual and collective …

Depaul Digest

DePaul Magazine

Melissa Ockerman, a school counseling professor, publishes guidance on how institutions can address the youth mental health crisis through de-escalating conflicts and cultivating social-emotional well-being. Noé de la Sancha, associate professor of environmental science, studies urban rat populations to better understand the impact of human-driven habitat change and loss on mammals. Plus, news briefs on exciting developments at DePaul University’s 10 colleges and schools, from a new Department of Neuroscience to robotics engineering in a new CyberLabs facility, and DePaul Connect, a community connecting alumni and students for network and mentor opportunities.

Class Notes

DePaul Magazine

From promotions to performances, see the latest accomplishments by DePaul alumni across class years and generations. Plus, read alumni spotlight profiles of Rudy Hodgson (CMN ’22), a pro hockey announcer, and Rania Elalej (BUS ’20), an international hotel operations specialist.

Molecular Determinant Of Low-Voltage Dependence Of Human Nav1.7 Inactivation Revealed By Efficacy-Based Nav1.7 Selective Inhibitor, Fang Zhao, Chuchu Xi, Jie Li, Kerui Ren, Qinglian Tang, Huaduan Liang, Shilong Yang, Michael X Zhu, Zhengyu Cao

Faculty, Staff and Student Publications

Nav1.7 is a voltage-gated sodium channel (VGSC) subtype predominantly expressed in sensory neurons, amplifying threshold currents. Here, we identify that Uvarigranol D (UGD) suppresses human (h) Nav1.7 with a much greater maximal inhibition than other VGSC subtypes, despite having similar apparent affinities. We demonstrate that Thr1398 determines the greater inhibitory efficacy of UGD, the leftward shift in voltage-dependence and faster inactivation kinetics of hNav1.7. UGD binds to the inactivated state, with Gln360, Ile394, Lys1395, Phe1737, and Tyr1744 being critically involved. Moreover, while UGD suppresses action potentials in both rat dorsal root ganglion neurons and human induced pluripotent stem cell-derived cardiomyocytes, …

Decitabine-Cedazuridine In Patients With Mds And Tp53 Mutations, Samuel Urrutia, Koji Sasaki, Alex Bataller, Hagop Kantarjian, Guillermo Montalban-Bravo, James Mccloskey, Elizabeth A Griffiths, Karen Yee, Amer Zeidan, Michael Savona, Aram Oganesian, Yuri Sano, Harold N Keer, Guillermo Garcia-Manero

Faculty, Staff and Student Publications

No abstract provided.

Channel Gating In Bacteriorhodopsin-Like Channelrhodopsins With Contrasting K+ And Na+ Selectivity, Oleg A Sineshchekov, Elena G Govorunova, Hai Li, Yumei Wang, John L Spudich

Faculty, Staff and Student Publications

Two closely homologous channelrhodopsins from Hyphochytrium catenoides, known as HcKCR1 (kalium channelrhodopsin 1) and HcCCR (cation channelrhodopsin), exhibit >100 times different K+/Na+ relative permeabilities and are emerging optogenetic tools for controlling neurons and cardiomyocytes. Key residue motifs and trimeric organization relate them structurally to bacteriorhodopsin-like cation channelrhodopsins (BCCRs). Here, we demonstrate that they utilize a specific gating mechanism previously suggested for the earlier-discovered BCCR from cryptophytes. Using a comparative analysis of transient absorption changes and photocurrents under single-turnover conditions, we identified an early, far-UV-absorbing photocycle intermediate that precedes channel opening in wild-type HcKCR1 and HcCCR. The UV-absorbing product is a …