Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Medicine and Health Sciences (325781)
- Social and Behavioral Sciences (259240)
- Law (183146)
- Education (153957)
- Arts and Humanities (123212)
-
- Life Sciences (116434)
- Medical Specialties (77032)
- Physical Sciences and Mathematics (64841)
- Higher Education (59357)
- Public Health (55643)
- Business (51253)
- History (50476)
- Psychology (48833)
- Medical Sciences (45194)
- Sociology (43965)
- Communication (43609)
- Engineering (41047)
- Nursing (34141)
- Public Affairs, Public Policy and Public Administration (33192)
- Library and Information Science (25740)
- Environmental Sciences (24937)
- United States History (21830)
- Religion (21812)
- Diseases (21751)
- Journalism Studies (21680)
- Mass Communication (21326)
- Educational Administration and Supervision (18004)
- Economics (17950)
- Rehabilitation and Therapy (16629)
- Social History (16393)
- Institution
-
- University of New Mexico (56018)
- University of New Hampshire (43697)
- University of Nebraska - Lincoln (37647)
- University of Montana (27877)
- The Texas Medical Center Library (27454)
-
- University of Colorado Law School (24806)
- University of Mississippi (24678)
- University of South Florida (22929)
- Murray State University (21689)
- Washington University School of Medicine (20184)
- University of Kentucky (18291)
- Georgia Southern University (18175)
- San Jose State University (17419)
- Chulalongkorn University (17317)
- Walden University (16767)
- Utah State University (16513)
- Western Kentucky University (16401)
- Thomas Jefferson University (16382)
- Western Michigan University (16145)
- Gallaudet University (15146)
- Eastern Illinois University (15078)
- Sigma Theta Tau International Honor Society of Nursing (14730)
- Nova Southeastern University (14525)
- University of Central Florida (14425)
- University of Alabama at Birmingham (14418)
- Virginia Commonwealth University (14278)
- University of North Dakota (13937)
- California Polytechnic State University, San Luis Obispo (13717)
- Brigham Young University (12756)
- Bowling Green State University (12539)
- Keyword
-
- Newspaper (30168)
- Humans (28522)
- Female (13573)
- Education (13405)
- COVID-19 (12863)
-
- Student newspaper (12363)
- Male (11816)
- Newspapers (10319)
- Newsletter (9998)
- Animals (9188)
- Bowling Green State University (8945)
- Spartan Daily (8774)
- EIU (8523)
- Michigan (7935)
- History (7325)
- Higher education (7290)
- Eastern Illinois University (7249)
- United States (7247)
- Daily Eastern News (7141)
- Adult (7027)
- BG News (7010)
- Faculty (6313)
- N.M. (6305)
- Mental health (6222)
- Pennsylvania (6209)
- B.G. News (5981)
- Mice (5892)
- Collegeville (5821)
- Middle Aged (5769)
- Students (5680)
- Publication Year
-
- 2026 (48575)
- 2025 (75572)
- 2024 (79509)
- 2023 (77310)
- 2022 (76356)
-
- 2021 (76678)
- 2020 (74484)
- 2019 (65553)
- 2018 (61994)
- 2017 (60656)
- 2016 (57374)
- 2015 (53342)
- 2014 (48962)
- 2013 (45570)
- 2012 (44640)
- 2011 (38421)
- 2010 (35742)
- 2009 (32209)
- 2008 (29304)
- 2007 (26421)
- 2006 (24592)
- 2005 (22437)
- 2004 (20418)
- 2003 (18895)
- 2002 (17894)
- 2001 (16929)
- 2000 (16435)
- 1999 (15086)
- 1998 (14738)
- 1997 (14291)
- Publication
-
- Theses and Dissertations (30811)
- Walden Dissertations and Doctoral Studies (15576)
- Electronic Theses and Dissertations (15545)
- Faculty Publications (14368)
- Faculty, Staff and Student Publications (13689)
-
- Dissertations (12709)
- Session Laws 1951-2000 (12443)
- Faculty Scholarship (10225)
- Spartan Daily (School of Journalism and Mass Communications) (8078)
- Faculty, Staff and Students Publications (7732)
- Daily Mississippian (all digitized issues) (7637)
- Articles (7455)
- Open Access Publications (7412)
- 2020-Current year OA Pubs (7383)
- BG News (Student Newspaper) (7107)
- Santa Fe New Mexican, 1883-1913 (6966)
- Master's Theses (6843)
- Montana Kaimin, 1898-present (6764)
- Theses (6568)
- Chulalongkorn University Theses and Dissertations (Chula ETD) (6481)
- Browse All News (6430)
- Masters Theses (6389)
- The Murray Ledger & Times (6370)
- Honors Theses (5931)
- Doctoral Dissertations and Projects (5824)
- Session Laws 2001-Present (5710)
- USF Tampa Graduate Theses and Dissertations (5473)
- International Nursing Research Congress (INRC) (5316)
- Graduate Theses, Dissertations, and Problem Reports (ETD) (5148)
- Saudi Medical Journal (5073)
- Publication Type
Articles 33961 - 33990 of 1791766
Full-Text Articles in Entire DC Network
The Social Worker As Interrogator: The Nasw Code Of Ethics And The Duty To Warn, Jennifer A. Brobst
The Social Worker As Interrogator: The Nasw Code Of Ethics And The Duty To Warn, Jennifer A. Brobst
Journal of Health Care Law & Policy Online Issue
No abstract provided.
Psilocybin And Animal Testing: Charting An End To The Use Of Animals In Drug Development Research, Amanda L. Elyse
Psilocybin And Animal Testing: Charting An End To The Use Of Animals In Drug Development Research, Amanda L. Elyse
Journal of Health Care Law & Policy Online Issue
No abstract provided.
Justice For Our Nation's Elders: Why The Health & Hospital Corporation V. Talevski Decision Is A Victory For Elder Rights, Aryana Ravery
Justice For Our Nation's Elders: Why The Health & Hospital Corporation V. Talevski Decision Is A Victory For Elder Rights, Aryana Ravery
Journal of Health Care Law & Policy Online Issue
No abstract provided.
City Of Grants Pass, Oregon V. Johnson: The Intersection Of Health, Homelessness, And Eighth Amendment Protections Against Cruel And Unusual Punishment, Jordan Hartung
Journal of Health Care Law & Policy Online Issue
No abstract provided.
Clinical Practice Guideline For Universal Anxiety Screening For Advanced Practice Providers, Kelechi Blanton
Clinical Practice Guideline For Universal Anxiety Screening For Advanced Practice Providers, Kelechi Blanton
Walden Dissertations and Doctoral Studies
This project was a clinical practice guideline (CPG) focused on anxiety screening in a primary care setting using the Generalized Anxiety Disorder (GAD-7) screening tool. The practice problem addressed general anxiety disorder and the need for standardized assessments for risk, as recently been recommended by the U.S. Prevention Service Task Force (USPSTF). Anxiety disorder is common but frequently untreated, due in part to low rates of screening. Lack of an evidence-based guideline for anxiety screening may contribute to delayed diagnosis and inconsistencies. The practice-focused question was, Does the evidence support development of an evidence-based CPG for universal anxiety screening in …
Experiences Of Loneliness And Belonging Among U.S.-Born Women During The Covid-19 Pandemic In Germany, Anna Sizorina
Experiences Of Loneliness And Belonging Among U.S.-Born Women During The Covid-19 Pandemic In Germany, Anna Sizorina
Walden Dissertations and Doctoral Studies
Existing literature indicates that the COVID-19 pandemic led to increased levels of loneliness, particularly among individuals with transnational ties. Travel and entry bans, along with social distancing, led to separation from family abroad and from people and communities in the countries of new residence. In this qualitative phenomenological study, experiences of loneliness and belonging among U.S.-born women during the COVID-19 Pandemic in Germany were explored. The transaction theory of stress guided the scientific enquiry, and the evolutionary theory of loneliness served as a conceptual framework for examining loneliness in the given context. Six adult female participants, born in the United …
Repurposing Erisa As The Protector Of Health Insurance Beneficiaries, D. Brian Hufford
Repurposing Erisa As The Protector Of Health Insurance Beneficiaries, D. Brian Hufford
Journal of Health Care Law & Policy Online Issue
No abstract provided.
Improving Blood Pressure Control In Home Care Patients Through Implementation Of Acc/Aha Hypertension Guidelines And Structured Blood Pressure Monitoring, Farrah Lynn Yuille
Improving Blood Pressure Control In Home Care Patients Through Implementation Of Acc/Aha Hypertension Guidelines And Structured Blood Pressure Monitoring, Farrah Lynn Yuille
Walden Dissertations and Doctoral Studies
This clinical practice guideline addressed the practice problem of the lack of standardized and consistent hypertension management in the home setting. Addressing this practice problem is important within nursing practice, as uncontrolled blood pressure increased the risk of hospitalizations, emergency department visits, and long-term cardiovascular complications. The practice question focused on translating evidence-based hypertension guidelines into clinical practice and evaluating their impact on patient outcomes in the home care setting. The purpose of the project was to engage three voluntary participants in evaluating the clinical practice guideline per the American College of Cardiology and American Heart Association hypertension guidelines within …
Work-Life Balance And Occupational Stress: Moderating Factors Among African American Telecommunication Workers, Robert Charity
Work-Life Balance And Occupational Stress: Moderating Factors Among African American Telecommunication Workers, Robert Charity
Walden Dissertations and Doctoral Studies
After the COVID-19 pandemic, remote call center employees faced intensified challenges in maintaining work-life balance (WLB) while experiencing elevated occupational stress (OS) levels. The purpose of this quantitative correlational study was to investigate the relationship between WLB and OS among African American (AA) call center professionals employed in the telecommunications industry, moderated by resilience (RS), gender, and generational age (GenAge). The theoretical framework included boundary theory, the job demands-control model, and resilience theory. The participants comprised 103 AA telecommunications call center professionals aged 28 to 65 in the southwestern United States. They completed the work-life balance scale, perceived occupational stress …
Staff Education Using A Workplace Violence Reduction Bundle, Julla Panneh
Staff Education Using A Workplace Violence Reduction Bundle, Julla Panneh
Walden Dissertations and Doctoral Studies
This Doctor of Nursing Practice (DNP) quality improvement project addressed the ongoing issue of workplace violence (WPV) among medical-surgical nurses in an acute care setting. WPV poses significant risks to staff safety, psychological well-being, and the overall care environment. Guided by current evidence and professional guidelines, the project implemented a structured educational intervention focused on the Workplace Violence Reduction Bundle, incorporating the Broset Violence Checklist (BVC) and evidence-based de-escalation strategies. Medical-surgical nursing staff participated in tailored educational sessions; knowledge was assessed through pre- and post-intervention surveys, and program acceptability was evaluated through staff feedback. Data analysis revealed modest improvements in …
Impact Of Workplace Ostracism, Moderated By Personality Traits On Psychological Safety, Aniko Rastovac
Impact Of Workplace Ostracism, Moderated By Personality Traits On Psychological Safety, Aniko Rastovac
Walden Dissertations and Doctoral Studies
Psychological safety, an essential element for fostering collaboration, trust, and innovation, can be undermined by negative interactions in the workplace. Most importantly, a lack of psychological safety is a barrier to individual and organizational growth, development, and innovation, which is necessary for gaining a competitive organizational advantage. The present study examines the concept of workplace ostracism as a negative interaction in the workplace that affects psychological safety. Using the big five personality traits framework, Edmondson’s (1999) concept of psychological safety, and Tett et al.’s (2021) trait activation theory, this quantitative study examined how individual differences moderate the impact of workplace …
Fostering Healthy Work Environments With Nurse Manager Transition To Practice Program, Anastasia Y. Rose, Janelle Schira, Marja Ross
Fostering Healthy Work Environments With Nurse Manager Transition To Practice Program, Anastasia Y. Rose, Janelle Schira, Marja Ross
Creating Healthy Work Environments (CHWE)
Background: Healthy work environments need effective nursing leadership (Mabona et al., 2022). Many new nurse managers lack the skills and knowledge needed for leadership roles (Espinoza et al., 2009). Turnover of new nurse managers is high, which can have a negative impact on nurse retention and quality of care (Warden, 2021). Per a national survey, over 50% of nurse leaders intend to leave their positions within next 5 years (Warden, 2021). A new manager orientation and mentorship programs could impact their practice, retention, and quality indicators, improve job satisfaction, organizational culture, and patient outcomes, and foster a healthy work environment …
Beyond "Place Matters": Making Spatial Analysis Accessible With Dashboard-Driven Geography, Stephen Borders
Beyond "Place Matters": Making Spatial Analysis Accessible With Dashboard-Driven Geography, Stephen Borders
Public Health
This article presents an instructional module that uses Tableau to teach spatial thinking and policy geography through an analysis of Supplemental Nutrition Assistance Program (SNAP) participation. Tableau’s ability to integrate custom spatial files with demographic and health data makes it an accessible platform for introducing geographic inquiry without requiring specialized GIS expertise. The lesson guides instructors through building maps, bullet charts, and scatterplots that highlight gaps between eligibility and enrolment, while connecting food insecurity to health outcomes. By lowering technical barriers, Tableau provides a pedagogical bridge that helps educators foster spatial literacy in diverse classroom contexts.
This article was published …
Polycystic Ovary Syndrome Across The Lifespan, Lauren Roth
Polycystic Ovary Syndrome Across The Lifespan, Lauren Roth
Grand Rounds
- Understand PCOS as a multisystem, lifelong condition.
- Review pharmacologic and non-pharmacologic management strategies for PCOS.
- Recognize age-specific clinical implications of PCOS.
- Incorporate PCOS into risk assessment and decision-making.
Metagenomic Insights Into Antimicrobial Resistance In Small-Scale Poultry And Cattle Farms, Elijah Ayilaran, Agnes Kilonzo-Nthenge Agnes Kilonzo-Nthenge
Metagenomic Insights Into Antimicrobial Resistance In Small-Scale Poultry And Cattle Farms, Elijah Ayilaran, Agnes Kilonzo-Nthenge Agnes Kilonzo-Nthenge
Food and Animal Sciences Faculty Research
Antimicrobial resistance (AMR) poses a critical challenge to global health, with food animal production systems recognized as significant reservoirs of antimicrobial-resistant bacteria. This study evaluated the prevalence and distribution of antimicrobial resistance genes (ARGs) and virulence factors (VFs) across small-scale poultry and cattle farms. A total of 468 samples (soil, feces, water, and natural land soil) were collected from four farms and analyzed using shotgun metagenomics. Proteobacteria (34.91%) were the dominant phylum across environments, followed by Cyanobacteria (15.67%), Actinobacteria (14.95%), Firmicutes (10.57%), and Bacteroidetes (8.69%). Tetracycline (33.41%) and beta-lactam (30.30%) resistance genes were the most abundant, with macrolide (9.32%) and …
Facilities Management Crews Fight Ice Storm On All Fronts, Carter Diggs
Facilities Management Crews Fight Ice Storm On All Fronts, Carter Diggs
University of Mississippi News
OXFORD, Miss. – As winter storm "Fern" slowly knocked out power and took down trees across Lafayette County, two dozen University of Mississippi employees waited in The Inn at Ole Miss, knowing that the hard work was about to begin.
Spectator 2026-02-12, Editors Of The Spectator
Beyond Rationality: The Role Of Emotions In Communicative Planning, Minji Cho
Beyond Rationality: The Role Of Emotions In Communicative Planning, Minji Cho
Urban Studies and Planning Faculty Publications and Presentations
The impact of emotional dynamics has been overlooked within the field of planning. Traditional communicative planning theory, rooted in Habermas’ model of communication, typically propose that emotions should be managed to facilitate rational discussions that lead to logical agreements. Conversely, some research contends that emotions are not illogical or hazardous elements to be restrained during deliberation; instead, they are a topic requiring thorough investigation to create improved public forums. We investigate this tension by analysing facework during a land-use dispute at at the Gongjin Elementary School site in Seoul, South Korea. Our analysis reveals that facework not only impedes the …
Green Vessel Signal On Multicolor Imaging As An Early Sign Of Ischemic Vasculitis In Irvan Syndrome: A Case Report, Daniel M. Markowitz, Jirat Nimworaphan, Carl Regillo, James P. Dunn, Robert C. Sergott
Green Vessel Signal On Multicolor Imaging As An Early Sign Of Ischemic Vasculitis In Irvan Syndrome: A Case Report, Daniel M. Markowitz, Jirat Nimworaphan, Carl Regillo, James P. Dunn, Robert C. Sergott
Wills Eye Hospital Papers
PURPOSE: Idiopathic retinitis, vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome is typically diagnosed after characteristic intravenous fluorescein angiography (IVFA) findings develop. This case demonstrates that identifying a green intravascular and perivascular signal on multicolor fundus imaging may be a potential noninvasive imaging sign for ischemic retinal vasculitis in IRVAN.
OBSERVATIONS: A 55-year-old female presented with bilateral optic disc edema and subtle peripapillary retinal vascular changes. Multicolor imaging showed a distinct green intravascular and perivascular signal before undergoing IVFA evaluation. Subsequent IVFA ultimately showed peripheral capillary nonperfusion, microaneurysms, and leakage consistent with IRVAN.
CONCLUSIONS AND IMPORTANCE: This case demonstrates the potential utility …
Psychiatric Nursing Staff Promoting The Use Of Long-Acting Injectables Antipsychotics, Yetunde Oloto
Psychiatric Nursing Staff Promoting The Use Of Long-Acting Injectables Antipsychotics, Yetunde Oloto
Walden Dissertations and Doctoral Studies
This project is a staff education aimed at improving psychiatric staff knowledge regarding the use of long-acting injectable (LAI) antipsychotics among patients with schizophrenia. The practice problem addressed was the limited use of LAIs among psychiatric nurses when treating schizophrenia patients, which contributes to medication non-adherence and subsequent relapse, hospitalization, increased healthcare costs, and diminished quality of life. In nursing practice, this problem is important because nurses are frontline practitioners who administer medications, provide education, and monitor patient adherence. The problem-focused question developed was “Among psychiatric nurses, does staff education on the use of long-acting injectable antipsychotics compared to oral …
Staff Education To Improving Patient Safety Outcomes Through Structured Staff Education, Imuetinyan Phillipa Ehondor
Staff Education To Improving Patient Safety Outcomes Through Structured Staff Education, Imuetinyan Phillipa Ehondor
Walden Dissertations and Doctoral Studies
This staff education doctoral project was implemented to address inconsistent staff knowledge of patient safety principles, disproportionate adherence to safety practices, and underutilization of standardized educational resources in an acute care clinic setting. It was important to address this issue in the context of nursing practice because patient safety is foundational to high-quality health care, directly influencing patient outcomes, regulatory compliance, organizational performance, and workforce morale. The practice-focused question was the following: In an acute care clinic, how does the implementation of a standardized safety protocol education program, compared to existing practices, impact staff knowledge regarding a culture of safety? …
The Indiana Statesman, February 12, 2026, Indiana State University
The Indiana Statesman, February 12, 2026, Indiana State University
Student Newspaper
SGA candidates make their case; Clapp & Tesmer; Lancaster & Pekny
Colonisation, Globalisation And A Pandemic: Developing Understandings Of Inclusive Education In Malaysia, Vicky Bamsey, Yee Ling Lee, Moses Samuel
Colonisation, Globalisation And A Pandemic: Developing Understandings Of Inclusive Education In Malaysia, Vicky Bamsey, Yee Ling Lee, Moses Samuel
School of Law, Humanities and Social Sciences
This is a theoretical paper that examines how colonisation, globalisation and a crisis such as the Covid-19 pandemic have had a significant influence on the development of inclusive education policy and practice in Malaysia. Drawing on the ideas of dependency from Farid Alatas, and Carol Bacchi’s focus on the identification of the underlying problem within policies, as well as Stephen Ball’s policy cycle, we highlight how global events have repercussions at a policy level now and into the future. This paper contributes to the wider inclusive education debate through the innovative use of these three different theoretical lenses, informed by …
Keeping Up With… Graduate Student Research Support Models, Giovanna Colosi
Keeping Up With… Graduate Student Research Support Models, Giovanna Colosi
Librarian Publications
Graduate education plays a central role in many institutions’ academic missions and revenue models, yet national data from the Council of Graduate Schools (CGS) indicate that enrollment and application patterns have shifted unevenly over the past decade, varying by discipline, credential type, and institutional context. At the same time, the graduate student population is increasingly diverse in modality and life stage, with more students enrolling part time, studying online or in hybrid formats, and returning mid-career. These changes present significant implications for academic and research libraries, particularly as graduate students’ research needs remain intensive while their schedules and pathways grow …
February 2026 Graduate Council Minutes, University Of Nebraska At Kearney Graduate Council
February 2026 Graduate Council Minutes, University Of Nebraska At Kearney Graduate Council
Graduate Council Minutes
No abstract provided.
Heavy Metals As Endocrine Disruptors, Arzu Or Koca
Heavy Metals As Endocrine Disruptors, Arzu Or Koca
Turkish Journal of Medical Sciences
Heavy metals are widely recognized as endocrine-disrupting agents primarily originating from anthropogenic sources and persisting in soil, air, and water. This review aims to present an updated and comprehensive synthesis of current evidence regarding the endocrine-disrupting effects of heavy metals, with particular emphasis on their roles in the pathogenesis of common endocrine and metabolic disorders. The toxicological impact of these elements depends on the level and duration of exposure, their chemical form, and the biological susceptibility of target tissues. Chronic exposure, even at low doses, has been implicated in the development of diabetes mellitus, obesity, autoimmune thyroiditis, thyroid cancer, pubertal …
Prevalence Of Gout In The Sincan District Of Ankara, Türkiye: A Primary Care-Based Cross-Sectional Study, Riza Can Kardaş, Yasemi̇n Ünsal, Derya Yildirim, Hakan Tüzün, Mustafa Necmi̇ İlhan, Hami̇t Küçük, Abdurrahman Tufan, M. Aki̇f Öztürk
Prevalence Of Gout In The Sincan District Of Ankara, Türkiye: A Primary Care-Based Cross-Sectional Study, Riza Can Kardaş, Yasemi̇n Ünsal, Derya Yildirim, Hakan Tüzün, Mustafa Necmi̇ İlhan, Hami̇t Küçük, Abdurrahman Tufan, M. Aki̇f Öztürk
Turkish Journal of Medical Sciences
Background/aim: Gout, the most prevalent form of inflammatory arthritis, has shown a global increase in prevalence; however, data from Türkiye remain scarce, inconsistent, and largely confined to western regions. This study aimed to estimate the prevalence of gout among adults in the Sincan district of Ankara, Türkiye, and to provide updated data from a previously understudied region.
Materials and methods: This cross-sectional, community-based study employed a multistage design. Adults aged ≥18 years who presented to selected family health centers in Sincan between February and June 2023 were screened using a structured questionnaire. Individuals with suspected gout underwent comprehensive clinical evaluation, …
Developing Liposomal And Ethosomal Formulations With Potent Antioxidant And Cytotoxic Effects: Unleashing The Power Of Achillea Millefolium L., Esra Akkol, Sena Akçakaya Mutlu, Gökçe Şeker Karatoprak, Çi̇ğdem Yücel, Selen İlgün, Esra Köngül Şafak, Murat Koç
Developing Liposomal And Ethosomal Formulations With Potent Antioxidant And Cytotoxic Effects: Unleashing The Power Of Achillea Millefolium L., Esra Akkol, Sena Akçakaya Mutlu, Gökçe Şeker Karatoprak, Çi̇ğdem Yücel, Selen İlgün, Esra Köngül Şafak, Murat Koç
Turkish Journal of Medical Sciences
Background/aim: Achillea millefolium L., a plant rich in phenolics and flavonoids, has been shown to possess strong antioxidant and cytotoxic properties. However, no pharmaceutical formulations have yet been developed for this plant. This study aimed to create and characterize an A. millefolium extract with high antioxidant and cytotoxic activities.
Materials and methods: A total of 10 extracts were prepared from the plant’s aerial parts using ethanol concentrations ranging from 10% to 99.9%. The DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS (2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) radical scavenging tests were used to assess the antioxidant properties of the extracts. Cytotoxic effects were assessed using the MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium …
Nonclassical Philadelphia-Positive Fish Signal Patterns In Cml And Seven Cases With Variant Philadelphia, Sevgi̇ Işik, Oğuz Çi̇li̇ngi̇r, Gülçi̇n Günden, Fi̇li̇z Yavaşoğlu, Hülya Özen, Mert Burak Raşan, Beyhan Durak Aras
Nonclassical Philadelphia-Positive Fish Signal Patterns In Cml And Seven Cases With Variant Philadelphia, Sevgi̇ Işik, Oğuz Çi̇li̇ngi̇r, Gülçi̇n Günden, Fi̇li̇z Yavaşoğlu, Hülya Özen, Mert Burak Raşan, Beyhan Durak Aras
Turkish Journal of Medical Sciences
Background/aim: Chronic myeloid leukemia (CML) is characterized by the Philadelphia chromosome (Ph), which occurs as a result of t(9;22). In 5%–10% of CML cases, variant t(9;22)s are observed. Additionally, while t(9;22) is formed, deletions can be observed in chromosomes 9 and 22. These deletions are observed more frequently in variant t(9;22). There is conflicting information in the literature about the prognostic effects of variant t(9;22) and deletions of 9q and 22q. There is also limited information about the frequency and breakpoints of other chromosomes involved in the variant t(9;22). Signal patterns other than the classical signal pattern of FISH analysis …
Tumor Targeting With Peptide-Drug Conjugates: Showcasing Key Progress And Hurdles, Keykavous Parang, Thuy Do, Clare Dinh, Dorna Davanidavari, Max Foroughi, Troy Khong, Mahsa Moazen, Amir Nasrolahi Shirazi
Tumor Targeting With Peptide-Drug Conjugates: Showcasing Key Progress And Hurdles, Keykavous Parang, Thuy Do, Clare Dinh, Dorna Davanidavari, Max Foroughi, Troy Khong, Mahsa Moazen, Amir Nasrolahi Shirazi
Pharmacy Faculty Articles and Research
Peptide-drug conjugates (PDCs) are modular, targeted therapeutics composed of a homing peptide linked to a cytotoxic or modulating drug payload via a cleavable/non-cleavable linker. PDCs utilize peptide targeting to enhance the delivery of potent drugs to tumors, providing advantages such as superior tissue penetration, reduced immunogenicity, and simpler manufacture compared to antibody-drug conjugates (ADCs). A comparison of PDCs versus ADCs highlights that PDCs’ small size (~1-3 kDa) enables deeper tumor penetration and faster clearance, whereas ADCs (~150 kDa) benefit from prolonged circulation but suffer from limited tissue diffusion. This review surveys recent advances in PDC design and application. We discuss …