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S6k1 Modulates Stat3 Activation To Promote Resistance To Radiotherapy In Lung Cancer, Ali Calderon-Aparicio, Noelle Francois, Tyler Grenda, Shan Xu, Olugbenga Okusanya, Jun He, Nicole L Simone

Department of Radiation Oncology Faculty Papers

Radiotherapy is a mainstay in the management of locally advanced lung cancer; however, intrinsic and acquired radioresistance contribute to poor prognosis. S6K1, a serine/threonine kinase, regulates cell growth, protein synthesis, and survival, and is increased in tumors, which is linked to enhanced survival under therapeutic stress, including radiation. The mechanisms, however, are not fully understood. This study investigates the role of S6K1 in lung cancer radioresistance and the mechanisms involved. Intrinsic radioresistance in lung cancer cells was associated with increased S6K1 activation. Pharmacologic inhibition or genetic deletion of S6K1 enhanced radiosensitivity both in vitro and in vivo, highlighting the therapeutic …

Tumor Microenvironment Transcriptional Activity Enables Robust Stratification Of Chemotherapy Response In Triple-Negative Breast Cancer, Yaoyi Dai, Xiaoxi Pan, Shuai Guo, Shuangxi Ji, Shaolong Cao, Matthew D Montierth, Yujie Jiang, Jeffrey T Chang, Leming Shi, Shabnam Shalapour, Gloria V Echeverria, Lucy Yates, Johan Staaf, Bora Lim, Yinyin Yuan, Wenyi Wang

Faculty, Staff and Student Publications

Triple-negative breast cancer (TNBC) exhibits heterogeneous treatment responses, yet molecular subtypes based on predefined biological pathways show limited prognostic value. We introduce tumor-specific total mRNA expression (TmS), a pathway-agnostic deconvolution metric derived from matched RNA/DNA sequencing, as a robust stratification tool. Analyzing 575 TNBC patients across Western and East Asian populations, TmS outperforms established subtypes in predicting chemotherapy outcomes, stratifying patients into high TmS with favorable prognosis and low TmS with poor prognosis. Stromal enrichment with immune exclusion emerges as a universal feature of chemotherapy-resistant low-TmS tumors across all cohorts. Population-specific features distinguish Asian cohorts: high-TmS tumors exhibit cell cycle-driven …

Expectant Management Vs Medication For Patent Ductus Arteriosus In Preterm Infants: The Pda Randomized Clinical Trial, Matthew M Laughon, Sonia M Thomas, Kristi L Watterberg, Kathleen A Kennedy, Martin Keszler, Namisavayam Ambalavanan, Alexis S Davis, Jonathan L Slaughter, Ronnie Guillet, Tarah T Colaizy, C Michael Cotten, Megan A Dhawan, Carl L Bose, Jennifer Talbert, Sarah Smucny, William E Benitz, Matthew A Rysavy, Robin K Ohls, Mariana C Baserga, Sara B Demauro, Mambarambath Jaleel, Wesley M Jackson, Waldemar A Carlo, Karen M Puopolo, Anna Maria Hibbs, Anup Katheria, Pablo J Sánchez, Carl T D'Angio, Ravi M Patel, Beth Ann Johnson, Valerie Y Chock, Abhay J Bhatt, Stephanie L Merhar, Ryan Moore, Abbot R Laptook, Sarvin Ghavam, Janell Fuller, Shilpa Vyas-Read, Stephen D Kicklighter, Baiba Steinbrekera, Kathryn Anderson, Praveen K Chandrasekharan, Myra H Wyckoff, Cassandra Montoya, Abhik Das, Barbara Do, Samantha Chang, Rosemary D Higgins, Michele C Walsh

Faculty, Staff and Student Publications

Importance: The management of patent ductus arteriosus (PDA) in preterm infants is controversial.

Objective: To determine whether expectant management compared with active treatment of a protocol-defined PDA in preterm infants decreases the incidence of death or bronchopulmonary dysplasia (BPD).

Design, setting, and participants: A randomized clinical trial including infants born at 22 to 28 weeks' gestation and diagnosed with a protocol-defined PDA between the age of 48 hours and 21 days at screening. The trial was conducted from December 2018 to December 2024 at 33 hospitals within the National Institute of Child Health and Human Development Neonatal Research Network. The …

Syndecan-1-Targeted Therapeutic Antibody Impairs Macropinocytosis And Elicits Antitumor Immunity In Pancreatic Cancer, Zecheng Yang, Madelaine S Theardy, Shuaitong Chen, Yongkun Wei, Mitsunobu Takeda, Yue Zeng, Xiaofei Wang, Jun Yao, Jennifer Li, Prapassorn Thirasastr, Jangho Park, Yangxi Zheng, Long T Vien, Khalida M Wani, Huamin Wang, Sisi Gao, Tim Heffernan, Lawrence Kwong, Ignacio I Wistuba, Laura Bover, Giulio F Draetta, Haoqiang Ying, Wantong Yao

Faculty, Staff and Student Publications

Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies, with a 5-year survival rate of just 13%. While the development and early clinical use of small molecules targeting oncogenic KRAS mutations, key drivers of PDAC, have shown promise, resistance to these targeted therapies remains a significant challenge. We recently identified Syndecan-1 (SDC1), a highly expressed heparan sulfate proteoglycan, as a critical KRAS effector protein that promotes nutrient salvage and tumor growth. Here, we report the development of a human-specific monoclonal antibody (anti-SDC1 mAb) that inhibits PDAC cell proliferation in vitro and suppresses PDAC tumor growth in vivo. Mechanistically, …

University Placed-Based Community Engagement And Adult Learners: A Field Report In Mutual Flourishing, Elisabeth Stevens, Kate Witvliet, Abbie Lipsker, Craig Mattson

University Faculty Publications and Creative Works

Although higher education increasingly focuses on both community engagement and adult learners, community-engaged research rarely considers them together. This article bridges the gap in the literature between undergraduate adult learners and community engagement. Providing one example of a partnership that considers adult learners as necessary partners for community engagement, Calvin University’s 49507 Initiative is a place-based community educational project in southeast Grand Rapids, Michigan, focusing on the goals and needs of adult learners in the 49507 zip code and adjacent neighborhoods. Through 12 focus groups in the community, adult residents discussed their interests in higher education, identified barriers to higher …

Lipidomic Profiles Associated With Treatment Related Hepatotoxicity In Children With Acute Lymphoblastic Leukemia., Emily J Mason, Jeremy M Schraw, John P Woodhouse, M Monica Gramatges, Kevin J Williams, Baojiang Chen, Melissa B Harrell, Olga A Taylor, Michael E Scheurer, Philip J Lupo, Karen R Rabin, Joanna S Yi, Van Huynh, Steven D Mittelman, Etan Orgel, Austin Brown

Faculty, Staff and Students Publications

Introduction: Treatment for childhood acute lymphoblastic leukemia (ALL) can result in hepatotoxicity. Despite being a common complication of ALL therapy, mechanisms and biomarkers of treatment-associated hepatotoxicity (TAH) are not well described.

Methods: We conducted lipidomic profiling to identify plasma lipids associated with TAH in children receiving ALL therapy utilizing a nested case-control framework. TAH was defined as (1) transaminitis: ALT/AST ≥ CTCAE grade 3, and/or (2) conjugated hyperbilirubinemia: > 3.0 mg/dL during induction therapy or > 2.0 mg/dL post induction. A total of 90 patients (45 matched pairs) treated at Texas Children's Hospital between 2012 and 2021 were selected for lipidomic profiling, …

Spatiotemporal Histogenesis Of The Developing Human Cerebellum Reveals Dynamic Layering Of Bergmann Glia, Guanyi He, Simon Du, Henry Tan, Sri Yellampally, Anders W Erickson, Virginia Fernandez, Ferechte Encha-Razavi, Kimberley A Phillips, Christine Haberler, Nicole Amberg, Victor Borrell, Paul A Northcott, Michael D Taylor, Kathleen J Millen, Parthiv Haldipur

Faculty, Staff and Students Publications

Bergmann glia (BG) are a specialized glial population essential for cerebellar development, yet their developmental timeline and molecular identity in the human cerebellum remain poorly understood. Here, we combined detailed histopathological analysis with spatial transcriptomics and single-nucleus RNA sequencing to generate a developmental atlas of human cerebellar BG. Histology revealed that BG emerge around 11 post-conception weeks (PCW), initially serving as a scaffold for Purkinje cells (PCs) migrating into the PC layer of the cerebellar cortex. Following the establishment of a multilayered PC arrangement, BG form a distinct parallel layer separated from the PCs by the lamina dissecans (LD), with …

Unravelling Antecedents And Bidirectional Impacts Of Nurse Work Rumination: A Scoping Review To Enhance Nurses’ Well-Being And Improve Nursing Quality, Wenjun Hu, Xiaofeng Xie, Xun Xu, Siying Wei, Ling Zhu, Yawen An

Faculty Research, Scholarly, and Creative Activity

Background Globally, work rumination is a common phenomenon related to nurse burnout. However, most existing studies focus on the single negative impacts of rumination, with less exploration of its dual effects and antecedents. Therefore, comprehensively exploring the effect of nurse work rumination and its influencing factors is crucial for enhancing the accuracy of nursing management. Objectives Identify the antecedents and dual effects of nurse work rumination to deepen understanding of this phenomenon and provide references for formulating interventions that enhance nurses’ well-being and improve the quality of nursing work. Eligibility criteria Included studies were original research articles focusing on work-related …

Re: Conditional Approval Letter With Comments For Butte Priority Soils Operable Unit (Bpsou) Draft Final 2026 Interim Site-Wide Surface Water Monitoring Quality Assurance Project Plan (Qapp) (Dated February 4, 2026), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Racial And Sex Differences In Acute Pericarditis Among Emergency Department Chest Pain Patients: A Retrospective Cohort Study, Joshua Emakhu, Wan Ting Su, Jamie Joseph, Indra Adrianto, Christiana David, Egbe Etu Etu, Imokhai Tenebe, Andrew Bossick, Joseph Miller

Faculty Research, Scholarly, and Creative Activity

Background: Acute pericarditis is a rare diagnosis among emergency department (ED) patients with chest pain, and how race and sex jointly influence risk remains poorly characterized. We evaluated race–sex heterogeneity in acute pericarditis risk using interaction-based and marginal analytic approaches. Methods: This retrospective cohort study utilized patient-level electronic health records from 10 EDs in a large integrated health system (2016–2022). Adult patients (≥ 18 years) self-identifying as non-Hispanic Black or non-Hispanic White and presenting with chest pain were included. Acute pericarditis was identified using International Classification of Diseases, Tenth Revision codes I30.x, supported by clinical documentation. Generalized linear models with …

Evaluating The American Society Of Hematology Quality Measure On Timeliness Of Analgesics For Sickle Cell Disease Pain Crisis, Ibrahim Gwarzo, Harish Chandra Dega, Paula Tanabe, Robin Miller, David C. Brousseau

Department of Medicine Faculty Papers

The American Society of Hematology (ASH) proposed the median time to first emergency department (ED) administration of pain medication for patients with sickle cell disease (SCD) vaso-occlusive pain episodes (VOE) as a site-level quality measure. Generalizable studies assessing current guideline adherence recommending pain medications within 60 minutes are lacking. We leveraged multisite electronic health record data from Epic's Cosmos research platform to analyze ED encounters for SCD VOE from 1 January 2019 to 31 December 2024, with administration of at least 1 pain medication. We calculated the quality measure (median time to first pain medication) and ranked sites based on …

Molecular Profiling And Tumor Biomarker Analysis Of Gog281/Logs: A Positive Late-Phase Trial Of Trametinib For Recurrent/Persistent Low-Grade Serous Ovarian Carcinoma, Robert L. Hollis, Austin Miller, Heather A. Lankes, Kwong-Kwok Wong, William Rodgers, David Millan, Karen Carty, Robert L. Coleman, Kathleen N. Moore, Angeles Alvarez Secord, David M. O'Malley, John K. Chan, Andrea R. Hagemann, Stephanie Gaillard, Saketh R. Guntupalli, Mitchell I. Edelson, Peter G. Rose, Oliver Dorigo, Susana Banerjee, Ailith Ewing, Michael Churchman, Anil K. Sood, C. Simon Herrington, Charlie Gourley, David M. Gershenson

Abington Jefferson Health Papers

PURPOSE: Low-grade serous ovarian carcinoma (LGSOC) is a distinct form of ovarian cancer characterized by younger patient age and relative chemoresistance. The GOG281/LOGS trial (NCT02101788) investigated the efficacy of the MEK inhibitor trametinib compared with physician's choice standard-of-care (SOC) in patients with LGSOC with persistent/recurrent disease. The study demonstrated significantly improved progression-free survival (PFS) in the trametinib-treated arm.

EXPERIMENTAL DESIGN: Two hundred and sixty patients with recurrent/persistent LGSOC were enrolled and randomly assigned in GOG281. We performed molecular analysis of 170 patients with available tumor specimens, comprising whole-exome sequencing and phospho-ERK (pERK) IHC, to identify biomarkers of clinical benefit from …

Taking It To The People: Translating Empirical Findings About Black Men And Black Families Through A Black Public Philosophy, Tommy J. Curry, Gwenetta D. Curry

Dewey Studies

No abstract provided.

Philosopher-As-Laison? Lessons From Sustainable Knowledge And American Philosophy, Danielle Lake, Paul Thompson

Dewey Studies

No abstract provided.

The Relationship Between Mindful Awareness And Acculturative Stress For International Undergraduate Students In America, Nandini Narula Bajpai, Mary Stone

International Journal of Undergraduate Research and Creative Activities

This study examines mindful awareness and its role in acculturative stress experienced by international undergraduate students in American colleges. Data from 101 students from 37 countries attending 35 colleges revealed a significant negative correlation between mindful awareness and acculturative stress (r[99] = -0.51, p < 0.001). Higher mindful awareness predicted lower general acculturative stress and specific subdomains. These findings aim to refine cultural adaptation frameworks and inform evidence-based support systems for international students.

The Nature Philosophy Of John Dewey, John R. Shook

Dewey Studies

No abstract provided.

The Poisoning Of Flint’S People, Vanessa Lamoureux

Fresh Voices: Composition at Cal Poly

No abstract provided.

Bring Music Bach, Marianna Pallas

Fresh Voices: Composition at Cal Poly

No abstract provided.

Women In Stem Fields, Jenna Riegel

Fresh Voices: Composition at Cal Poly

No abstract provided.

Financial Illiteracy Is Killing Us, Gabi Morgan

Fresh Voices: Composition at Cal Poly

No abstract provided.

Saving Lives One Green Roof At A Time, Danelle Christine Rekevics

Fresh Voices: Composition at Cal Poly

No abstract provided.

Obesity, Stigmas, And A Solution, Moyinoluwa Oyebanji

Fresh Voices: Composition at Cal Poly

No abstract provided.

Slow Fashion: The Simple, Sustainable Apparel, Lyle Bryson

Fresh Voices: Composition at Cal Poly

No abstract provided.

The Impression Of Culture In Medication: Bad Or Good?, Daphne Tan

Fresh Voices: Composition at Cal Poly

No abstract provided.

Pit.Fit, John Balido

Fresh Voices: Composition at Cal Poly

No abstract provided.

A Workout Alternative, Hailey Koetz

Fresh Voices: Composition at Cal Poly

No abstract provided.

Nyquil, Shoes Without Laces, And A Psychiatric Hospital In Petaluma, Samuel Light

Fresh Voices: Composition at Cal Poly

No abstract provided.

On The Fine Art Of Literary Fist-Fighting Pt. 2, Lee Gutkind

Creative Nonfiction Magazine

No abstract provided.

Notes From A Difficult Case, Ruthann Robson

Creative Nonfiction Magazine

No abstract provided.

Ramalamadingdong, Ellen Passarello

Creative Nonfiction Magazine

No abstract provided.