Digital Commons Network^™

Resilience In Young People Living With Hiv In Low To Middle-Income Countries: A Critical Review, Lily R. Bastian

Creating Healthy Work Environments (CHWE)

Background: According to the Joint United Nations Programme on HIV/AIDS (UNAIDS, 2023), 39 million people globally were living with HIV, and 1.3 million people became infected in 2022. Of those, 27% were young people (ages 15-24), including 210,000 young women and 140,000 young men. HIV is an expanding epidemic despite an overall reduction in the annual incidence percentage and the significant strides that have been made towards prevention of transmission and treatment with antiretroviral therapy (ART). Low to middle-income countries (LMICs) are especially vulnerable to the HIV/AIDs epidemic. The identification and promotion of resilience factors could play a crucial role …

The Recent Rash Of Biotechnology Risks: A Call To Fortify Force Capability, James Giordano

Strategic Insights

This commentary looks at recent incidents that highlight emerging national security risks posed by advances in biotechnology and synthetic biology. The discovery of suspicious biological materials stored in a residential facility in Reedley, California, and reports that a rare neurotoxin may have been used against Russian opposition leader Alexei Navalny illustrate how barriers to acquiring and operationalizing biological and chemical agents are declining. Tools such as gene editing, modular DNA assembly, laboratory automation, and AI-enabled biological design are expanding the range of actors capable of producing or modifying bioagents while complicating detection and attribution. Strengthened biodefense measures, including “biosecurity-by-design,” improved …

Executive Committee - Agenda, 02/17/2026, Academic Senate

Academic Senate Agendas

No abstract provided.

Stress Management And Resiliency Program For Accelerated Bsn Students In A Dedicated Education Unit, Marcela Alvarez-Lazo

Creating Healthy Work Environments (CHWE)

Background: About 12-25% of newly graduated nurses will leave nursing within the first-year post-graduation. These statistics surrounding nursing retention are alarming and are not expected to improve, as 900,000 nurses are projected to depart from nursing by the year 2027. Addressing the underlying issues are critical in making a real impact to increase retention.

Aim: This quality improvement project aims to integrate a Stress Management and Resiliency. Program for accelerated BSN nursing students. The project aims to apply a CBT-based program to increase the knowledge of principles of stress and resilience for nursing students and preceptors, decrease stress, increase resilience, …

Caregiving Experiences Of Latino And Caucasian Dementia Caregivers Amid Pandemic, Alexis Ross

Creating Healthy Work Environments (CHWE)

More than 6.7 million American older adults are diagnosed with Alzheimer’s and related dementias (Alzheimer’s Association, 2023). Caregivers for community dwelling persons living with dementia (PWD) are usually family members such as a spouse or offspring. Resources such as adult day care centers, in-home supportive services, and family support groups were widely used before the COVID-19 pandemic. Following the California ‘Stay-At-Home’ administrative order during the early pandemic, such necessary support services were forced to close.

The purpose of this study was to identify similarities and differences in caregiving experiences between Latino caregivers and non-Hispanic White caregivers of community dwelling persons …

The Effects Of Patient Care In Relation To Toxic Workplace Environments, Kayla Fitzgerald

Creating Healthy Work Environments (CHWE)

Background: Bullying in the workplace setting is a significant issue that can severely impact one’s career. Bullying can be demonstrated in several forms- such as verbal abuse, isolation, intimidation, and physical harm. Specific to nursing practice, workplace bullying is shown to have negative effects on mental health, patient care, and overall job satisfaction. While there are no definite means that organizations will take complete action towards this ongoing issue, several implementations can be instilled to reduce the incidence of workplace bullying.

Methods: In this project, studies of negative work environments, specifically workplace bullying, and patient care were critiqued and synthesized. …

Exploring The Impact Of Intersectional Identity On Maternal Morbidity/Birth Outcomes Among Afro-Latinas In Florida, Alexa Parra, Cynthia Lebron, Michaela Larson, Yue Pan, Jonell Potter, Hudson Santos

Creating Healthy Work Environments (CHWE)

Background: The “Hispanic/Latina Paradox" is a phenomenon where Latina women and their infants have perinatal and birth outcomes similar to those of White women. This is often seen as a protective mechanism that helps reduce maternal health inequities. However, this paradox overlooks the fact that there are different subgroups of Latina women, including Afro-Latinas, who are often neglected when addressing racial disparities related to perinatal birth outcomes in the US. The intersectionality of multiple minority identities may put Afro-Latinas at a disadvantage in terms of perinatal health outcomes.

Objective: Determine differences in maternal morbidity, including pregnancy-related hypertension and diabetes, and …

Screening For Postpartum Depression At A Suburban Chiropractic Clinic, Emma Stedronsky, Mary Degrote Goering

Creating Healthy Work Environments (CHWE)

Background: The pregnancy and postpartum period are crucial times to evaluate for mental health conditions. The American College of Obstetrics and Gynecology (ACOG) recommends that providers screen for perinatal and postpartum depression (PPD) at least once during pregnancy and once during the postpartum period using a validated screening tool. A chiropractic clinic in the upper Midwestern United States identified an anecdotal increase in mental health concerns in their pregnant and postpartum patient population since the COVID-19 pandemic. This project utilized interprofessional collaboration by implementing PPD screening at a chiropractic office according to the recommended guidelines using the Edinburgh Postnatal Depression …

Book Review: Cassino ’44: The Brutal Battle For Rome, Wylie W. Johnson

Parameters Bookshelf – Online Book Reviews

Author: James Holland

Reviewed by: Wylie W. Johnson, chaplain, US Army War College class of 2010

In this masterful retelling of the Italian Campaign’s final months, James Holland captures the harrowing struggle to break through the German Gustav Line and liberate Rome. Drawing from 20 years of research and firsthand accounts, he brings to life the chaos of Monte Cassino and Anzio through the eyes of soldiers, nurses, and civilians caught in the maelstrom. Cassino ’44 redefines our understanding of World War II’s most grueling campaign, revealing its strategic importance and human cost just days before the D-Day landings.

©2026 …

Lymphatic Pumping Failure In The Arm Precedes Dermal Backflow And Breast Cancer-Related Lymphedema, Melissa B Aldrich, Meghan E Mcwain, Simona F Shaitelman, Rian E Kuhns, John C Rasmussen, Wendy A Woodward, Sarah M Desnyder, Wenyaw Chan, Eva M Sevick-Muraca

The Brown Foundation: Institute of Molecular Medicine

Background

Breast cancer patients who undergo regional nodal irradiation therapy (RNI) following neoadjuvant chemotherapy and mastectomy or lumpectomy with axillary lymph node dissection (ALND) frequently encounter breast cancer-related lymphedema (BCRL). Early detection and treatment can significantly improve outcomes. Previously, near-infrared fluorescence lymphatic imaging (NIRF-LI) detection of dermal backflow, or retrograde lymphatic flow into initial lymphatics, was shown to precede clinical BCRL diagnosis by 8–23 months. Herein, we hypothesize that lymphatic pump failure is responsible for dermal backflow and may be a target to prevent onset of BCRL symptoms.

Methods

Arm lymphatics in 51 patients with locally advanced breast cancer were …

Non-Waivability In Labour Law: An Australian Perspective, Joellen Riley Munton

Comparative Labor Law & Policy Journal

Australian industrial relations laws traditionally provided detailed mandatory standards through a system of arbitrated occupation-based awards. In the years since a shift to enterprise bargaining, the system has tolerated a greater level of flexibility, even in the way that legislated minima are framed. The options for waiving otherwise mandatory standards are, however, limited by procedural protections. The Fair Work Commission maintains a supervisory role to ensure that workers are “better off overall” as a consequence of their bargains. This article explains the many ways in which Australian labour standards permit flexible application, within constraints designed to preclude exploitative practices.

Waiver Of Statutory Employment Rights In The United Kingdom, Hugh Collins

Comparative Labor Law & Policy Journal

The common law endorses the principle of freedom of contract, but, with few exceptions, Parliament has explicitly prevented straightforward waivers of statutory employment rights. Nevertheless, for the sake of promoting settlements of claims by employees, it is surprisingly easy for individual employees to enter into agreements to compromise claims for breach of those rights without appropriate safeguards such as independent advice and freedom from pressure. Moreover, employers’ lawyers have demonstrated considerable ingenuity in finding ways to avoid the application of employment rights either by manipulations of employment status or by seeking contractual agreements on the facts of the case that …

Relaxation Of Mandatory Rules Through Collective And Individual Agreements In Japanese Labour Law, Ryuichi Yamakawa

Comparative Labor Law & Policy Journal

This article analyses the legal situation in Japan regarding the relaxation of or deviation from mandatory regulations in labour law through collective and individual agreements. Although many statutory labour laws in Japan have a mandatory effect over individual employment contracts, several statutory provisions provide that such mandatory regulations can be relaxed through collective agreements under certain circumstances, as is the case in other industrialised countries. However, Japan’s situation is unique insofar as the relaxation is permissible through collective agreements concluded by non-union (individual) representatives of a majority of employees in the absence of union representatives who have been elected by …

Derogability By Collective Agreements In Germany And The Presumption, Eva Kocher

Comparative Labor Law & Policy Journal

The promotion of derogability clauses, which allow collective agreements to deviate from statutory protection to the detriment of employees, has been an issue in the political debate on German labour law for some 20 years. While such derogability clauses can effectively allow for flexibility at the company or sectoral level, there are differing views on their suitability for promoting collective bargaining. This article highlights the paradox of such derogability clauses: They are legitimised by the presumption of fairness that underpins collective autonomy; at the same time, they create incentives for employers that challenge the very presumption of fairness. All in …

The International Covenant On Economic, Social And Cultural Rights And The Employment Relation By Klaus Lörcher, Niklas Bruun, Ana Teresa Ribeiro, Hart Publishing, 2025, Manfred Weiss

Comparative Labor Law & Policy Journal

AFTER HAVING PUBLISHED THREE ENLIGHTENING BOOKS on the European Convention on Human Rights (ECHR), on the European Social Charter (ESC), and on the Charter of Fundamental Rights of the European Union (CFREU), the authors of the Transnational Trade Union Rights Expert Network of the European Trade Union Institute have now transcended the European territory and presented a publication on a global scale.

Spartan Daily, February 17, 2026, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2026

Volume 166, Issue 11

A Prospective Study Of Individuals At Risk Of Multiple Sclerosis Informs The Design Of Primary Prevention Studies, Amy Laitinen

All Publications

Objective: In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge. To inform this question, we examined the conversion of asymptomatic family members to a diagnosis of MS among Genes and Environment in Multiple Sclerosis (GEMS) project participants. We also evaluated an updated Genetic and Environmental risk score (GERS) and interest in participation in primary prevention trials.

Methods: GEMS is a nationwide prospective study of first-degree relatives …

S6k1 Modulates Stat3 Activation To Promote Resistance To Radiotherapy In Lung Cancer, Ali Calderon-Aparicio, Noelle Francois, Tyler Grenda, Shan Xu, Olugbenga Okusanya, Jun He, Nicole L Simone

Department of Radiation Oncology Faculty Papers

Radiotherapy is a mainstay in the management of locally advanced lung cancer; however, intrinsic and acquired radioresistance contribute to poor prognosis. S6K1, a serine/threonine kinase, regulates cell growth, protein synthesis, and survival, and is increased in tumors, which is linked to enhanced survival under therapeutic stress, including radiation. The mechanisms, however, are not fully understood. This study investigates the role of S6K1 in lung cancer radioresistance and the mechanisms involved. Intrinsic radioresistance in lung cancer cells was associated with increased S6K1 activation. Pharmacologic inhibition or genetic deletion of S6K1 enhanced radiosensitivity both in vitro and in vivo, highlighting the therapeutic …

Tumor Microenvironment Transcriptional Activity Enables Robust Stratification Of Chemotherapy Response In Triple-Negative Breast Cancer, Yaoyi Dai, Xiaoxi Pan, Shuai Guo, Shuangxi Ji, Shaolong Cao, Matthew D Montierth, Yujie Jiang, Jeffrey T Chang, Leming Shi, Shabnam Shalapour, Gloria V Echeverria, Lucy Yates, Johan Staaf, Bora Lim, Yinyin Yuan, Wenyi Wang

Faculty, Staff and Student Publications

Triple-negative breast cancer (TNBC) exhibits heterogeneous treatment responses, yet molecular subtypes based on predefined biological pathways show limited prognostic value. We introduce tumor-specific total mRNA expression (TmS), a pathway-agnostic deconvolution metric derived from matched RNA/DNA sequencing, as a robust stratification tool. Analyzing 575 TNBC patients across Western and East Asian populations, TmS outperforms established subtypes in predicting chemotherapy outcomes, stratifying patients into high TmS with favorable prognosis and low TmS with poor prognosis. Stromal enrichment with immune exclusion emerges as a universal feature of chemotherapy-resistant low-TmS tumors across all cohorts. Population-specific features distinguish Asian cohorts: high-TmS tumors exhibit cell cycle-driven …

Expectant Management Vs Medication For Patent Ductus Arteriosus In Preterm Infants: The Pda Randomized Clinical Trial, Matthew M Laughon, Sonia M Thomas, Kristi L Watterberg, Kathleen A Kennedy, Martin Keszler, Namisavayam Ambalavanan, Alexis S Davis, Jonathan L Slaughter, Ronnie Guillet, Tarah T Colaizy, C Michael Cotten, Megan A Dhawan, Carl L Bose, Jennifer Talbert, Sarah Smucny, William E Benitz, Matthew A Rysavy, Robin K Ohls, Mariana C Baserga, Sara B Demauro, Mambarambath Jaleel, Wesley M Jackson, Waldemar A Carlo, Karen M Puopolo, Anna Maria Hibbs, Anup Katheria, Pablo J Sánchez, Carl T D'Angio, Ravi M Patel, Beth Ann Johnson, Valerie Y Chock, Abhay J Bhatt, Stephanie L Merhar, Ryan Moore, Abbot R Laptook, Sarvin Ghavam, Janell Fuller, Shilpa Vyas-Read, Stephen D Kicklighter, Baiba Steinbrekera, Kathryn Anderson, Praveen K Chandrasekharan, Myra H Wyckoff, Cassandra Montoya, Abhik Das, Barbara Do, Samantha Chang, Rosemary D Higgins, Michele C Walsh

Faculty, Staff and Student Publications

Importance: The management of patent ductus arteriosus (PDA) in preterm infants is controversial.

Objective: To determine whether expectant management compared with active treatment of a protocol-defined PDA in preterm infants decreases the incidence of death or bronchopulmonary dysplasia (BPD).

Design, setting, and participants: A randomized clinical trial including infants born at 22 to 28 weeks' gestation and diagnosed with a protocol-defined PDA between the age of 48 hours and 21 days at screening. The trial was conducted from December 2018 to December 2024 at 33 hospitals within the National Institute of Child Health and Human Development Neonatal Research Network. The …

Syndecan-1-Targeted Therapeutic Antibody Impairs Macropinocytosis And Elicits Antitumor Immunity In Pancreatic Cancer, Zecheng Yang, Madelaine S Theardy, Shuaitong Chen, Yongkun Wei, Mitsunobu Takeda, Yue Zeng, Xiaofei Wang, Jun Yao, Jennifer Li, Prapassorn Thirasastr, Jangho Park, Yangxi Zheng, Long T Vien, Khalida M Wani, Huamin Wang, Sisi Gao, Tim Heffernan, Lawrence Kwong, Ignacio I Wistuba, Laura Bover, Giulio F Draetta, Haoqiang Ying, Wantong Yao

Faculty, Staff and Student Publications

Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies, with a 5-year survival rate of just 13%. While the development and early clinical use of small molecules targeting oncogenic KRAS mutations, key drivers of PDAC, have shown promise, resistance to these targeted therapies remains a significant challenge. We recently identified Syndecan-1 (SDC1), a highly expressed heparan sulfate proteoglycan, as a critical KRAS effector protein that promotes nutrient salvage and tumor growth. Here, we report the development of a human-specific monoclonal antibody (anti-SDC1 mAb) that inhibits PDAC cell proliferation in vitro and suppresses PDAC tumor growth in vivo. Mechanistically, …

Molecular Profiling And Tumor Biomarker Analysis Of Gog281/Logs: A Positive Late-Phase Trial Of Trametinib For Recurrent/Persistent Low-Grade Serous Ovarian Carcinoma, Robert L. Hollis, Austin Miller, Heather A. Lankes, Kwong-Kwok Wong, William Rodgers, David Millan, Karen Carty, Robert L. Coleman, Kathleen N. Moore, Angeles Alvarez Secord, David M. O'Malley, John K. Chan, Andrea R. Hagemann, Stephanie Gaillard, Saketh R. Guntupalli, Mitchell I. Edelson, Peter G. Rose, Oliver Dorigo, Susana Banerjee, Ailith Ewing, Michael Churchman, Anil K. Sood, C. Simon Herrington, Charlie Gourley, David M. Gershenson

Abington Jefferson Health Papers

PURPOSE: Low-grade serous ovarian carcinoma (LGSOC) is a distinct form of ovarian cancer characterized by younger patient age and relative chemoresistance. The GOG281/LOGS trial (NCT02101788) investigated the efficacy of the MEK inhibitor trametinib compared with physician's choice standard-of-care (SOC) in patients with LGSOC with persistent/recurrent disease. The study demonstrated significantly improved progression-free survival (PFS) in the trametinib-treated arm.

EXPERIMENTAL DESIGN: Two hundred and sixty patients with recurrent/persistent LGSOC were enrolled and randomly assigned in GOG281. We performed molecular analysis of 170 patients with available tumor specimens, comprising whole-exome sequencing and phospho-ERK (pERK) IHC, to identify biomarkers of clinical benefit from …

University Placed-Based Community Engagement And Adult Learners: A Field Report In Mutual Flourishing, Elisabeth Stevens, Kate Witvliet, Abbie Lipsker, Craig Mattson

University Faculty Publications and Creative Works

Although higher education increasingly focuses on both community engagement and adult learners, community-engaged research rarely considers them together. This article bridges the gap in the literature between undergraduate adult learners and community engagement. Providing one example of a partnership that considers adult learners as necessary partners for community engagement, Calvin University’s 49507 Initiative is a place-based community educational project in southeast Grand Rapids, Michigan, focusing on the goals and needs of adult learners in the 49507 zip code and adjacent neighborhoods. Through 12 focus groups in the community, adult residents discussed their interests in higher education, identified barriers to higher …

Lipidomic Profiles Associated With Treatment Related Hepatotoxicity In Children With Acute Lymphoblastic Leukemia., Emily J Mason, Jeremy M Schraw, John P Woodhouse, M Monica Gramatges, Kevin J Williams, Baojiang Chen, Melissa B Harrell, Olga A Taylor, Michael E Scheurer, Philip J Lupo, Karen R Rabin, Joanna S Yi, Van Huynh, Steven D Mittelman, Etan Orgel, Austin Brown

Faculty, Staff and Students Publications

Introduction: Treatment for childhood acute lymphoblastic leukemia (ALL) can result in hepatotoxicity. Despite being a common complication of ALL therapy, mechanisms and biomarkers of treatment-associated hepatotoxicity (TAH) are not well described.

Methods: We conducted lipidomic profiling to identify plasma lipids associated with TAH in children receiving ALL therapy utilizing a nested case-control framework. TAH was defined as (1) transaminitis: ALT/AST ≥ CTCAE grade 3, and/or (2) conjugated hyperbilirubinemia: > 3.0 mg/dL during induction therapy or > 2.0 mg/dL post induction. A total of 90 patients (45 matched pairs) treated at Texas Children's Hospital between 2012 and 2021 were selected for lipidomic profiling, …

Spatiotemporal Histogenesis Of The Developing Human Cerebellum Reveals Dynamic Layering Of Bergmann Glia, Guanyi He, Simon Du, Henry Tan, Sri Yellampally, Anders W Erickson, Virginia Fernandez, Ferechte Encha-Razavi, Kimberley A Phillips, Christine Haberler, Nicole Amberg, Victor Borrell, Paul A Northcott, Michael D Taylor, Kathleen J Millen, Parthiv Haldipur

Faculty, Staff and Students Publications

Bergmann glia (BG) are a specialized glial population essential for cerebellar development, yet their developmental timeline and molecular identity in the human cerebellum remain poorly understood. Here, we combined detailed histopathological analysis with spatial transcriptomics and single-nucleus RNA sequencing to generate a developmental atlas of human cerebellar BG. Histology revealed that BG emerge around 11 post-conception weeks (PCW), initially serving as a scaffold for Purkinje cells (PCs) migrating into the PC layer of the cerebellar cortex. Following the establishment of a multilayered PC arrangement, BG form a distinct parallel layer separated from the PCs by the lamina dissecans (LD), with …

Unravelling Antecedents And Bidirectional Impacts Of Nurse Work Rumination: A Scoping Review To Enhance Nurses’ Well-Being And Improve Nursing Quality, Wenjun Hu, Xiaofeng Xie, Xun Xu, Siying Wei, Ling Zhu, Yawen An

Faculty Research, Scholarly, and Creative Activity

Background Globally, work rumination is a common phenomenon related to nurse burnout. However, most existing studies focus on the single negative impacts of rumination, with less exploration of its dual effects and antecedents. Therefore, comprehensively exploring the effect of nurse work rumination and its influencing factors is crucial for enhancing the accuracy of nursing management. Objectives Identify the antecedents and dual effects of nurse work rumination to deepen understanding of this phenomenon and provide references for formulating interventions that enhance nurses’ well-being and improve the quality of nursing work. Eligibility criteria Included studies were original research articles focusing on work-related …

Re: Conditional Approval Letter With Comments For Butte Priority Soils Operable Unit (Bpsou) Draft Final 2026 Interim Site-Wide Surface Water Monitoring Quality Assurance Project Plan (Qapp) (Dated February 4, 2026), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Racial And Sex Differences In Acute Pericarditis Among Emergency Department Chest Pain Patients: A Retrospective Cohort Study, Joshua Emakhu, Wan Ting Su, Jamie Joseph, Indra Adrianto, Christiana David, Egbe Etu Etu, Imokhai Tenebe, Andrew Bossick, Joseph Miller

Faculty Research, Scholarly, and Creative Activity

Background: Acute pericarditis is a rare diagnosis among emergency department (ED) patients with chest pain, and how race and sex jointly influence risk remains poorly characterized. We evaluated race–sex heterogeneity in acute pericarditis risk using interaction-based and marginal analytic approaches. Methods: This retrospective cohort study utilized patient-level electronic health records from 10 EDs in a large integrated health system (2016–2022). Adult patients (≥ 18 years) self-identifying as non-Hispanic Black or non-Hispanic White and presenting with chest pain were included. Acute pericarditis was identified using International Classification of Diseases, Tenth Revision codes I30.x, supported by clinical documentation. Generalized linear models with …

Evaluating The American Society Of Hematology Quality Measure On Timeliness Of Analgesics For Sickle Cell Disease Pain Crisis, Ibrahim Gwarzo, Harish Chandra Dega, Paula Tanabe, Robin Miller, David C. Brousseau

Department of Medicine Faculty Papers

The American Society of Hematology (ASH) proposed the median time to first emergency department (ED) administration of pain medication for patients with sickle cell disease (SCD) vaso-occlusive pain episodes (VOE) as a site-level quality measure. Generalizable studies assessing current guideline adherence recommending pain medications within 60 minutes are lacking. We leveraged multisite electronic health record data from Epic's Cosmos research platform to analyze ED encounters for SCD VOE from 1 January 2019 to 31 December 2024, with administration of at least 1 pain medication. We calculated the quality measure (median time to first pain medication) and ranked sites based on …

Taking It To The People: Translating Empirical Findings About Black Men And Black Families Through A Black Public Philosophy, Tommy J. Curry, Gwenetta D. Curry

Dewey Studies

No abstract provided.