Digital Commons Network^™

Troponin Is Unrelated To Outcomes In Heart Failure Patients Discharged From The Emergency Department, Gregory J Fermann, Douglas Char, Et Al

2020-Current year OA Pubs

BACKGROUND: Prior data has demonstrated increased mortality in hospitalized patients with acute heart failure (AHF) and troponin elevation. No data has specifically examined the prognostic significance of troponin elevation in patients with AHF discharged after emergency department (ED) management.

OBJECTIVE: Evaluate the relationship between troponin elevation and outcomes in patients with AHF who are treated and released from the ED.

METHODS: This was a secondary analysis of the Get with the Guidelines to Reduce Disparities in AHF Patients Discharged from the ED (GUIDED-HF) trial, a randomized, controlled trial of ED patients with AHF who were discharged. Patients with elevated conventional …

Hypothermia For Patients Requiring Evacuation Of Subdural Hematoma: A Multicenter Randomized Clinical Trial, Georgene W Hergenroeder, Michael N Diringer, Et Al.

2020-Current year OA Pubs

BACKGROUND: Hypothermia is neuroprotective in some ischemia-reperfusion injuries. Ischemia-reperfusion injury may occur with traumatic subdural hematoma (SDH). This study aimed to determine whether early induction and maintenance of hypothermia in patients with acute SDH would lead to decreased ischemia-reperfusion injury and improve global neurologic outcome.

METHODS: This international, multicenter randomized controlled trial enrolled adult patients with SDH requiring evacuation of hematoma within 6 h of injury. The intervention was controlled temperature management of hypothermia to 35 °C prior to dura opening followed by 33 °C for 48 h compared with normothermia (37 °C). Investigators randomly assigned patients at a 1:1 …

Enhancing Discovery Of Genetic Variants For Posttraumatic Stress Disorder Through Integration Of Quantitative Phenotypes And Trauma Exposure Information, Adam X. Maihofer, Andrew C. Heath, Et Al.

2020-Current year OA Pubs

BACKGROUND: Posttraumatic stress disorder (PTSD) is heritable and a potential consequence of exposure to traumatic stress. Evidence suggests that a quantitative approach to PTSD phenotype measurement and incorporation of lifetime trauma exposure (LTE) information could enhance the discovery power of PTSD genome-wide association studies (GWASs).

METHODS: A GWAS on PTSD symptoms was performed in 51 cohorts followed by a fixed-effects meta-analysis (N = 182,199 European ancestry participants). A GWAS of LTE burden was performed in the UK Biobank cohort (N = 132,988). Genetic correlations were evaluated with linkage disequilibrium score regression. Multivariate analysis was performed using Multi-Trait Analysis of GWAS. …

The Need For A Gender Neutrality Policy In One State's 4-H Program, Nancy Ann Moores

Dissertations

Policies recognizing gender-neutrality and non-binary identities are needed in youth development programs to create a truly inclusive program and a sense of belonging for all youth. This study explored if and how written statewide policies regarding gender- neutrality can most effectively serve members, agents, and volunteers of the 4-H Youth Development Program in the state under study. The context of this study was the 4-H program in one state (agents and administrators as participants) and 4-H programs around the United States (administrators as participants).Preliminary qualitative and quantitative data from my research study indicated that agents in the state under study …

Understanding The Relationship Between Black Chicago Youth And Chicago Drill Music Culture, Dan'iel Tamirra Kendricks

Dissertations

Chicago is most noted as a beautiful, Midwestern city, set to the backdrop of Lake Michigan, with skyscrapers and the bustling energy of the downtown Magnificent Mile. The “Tale of Two Cities,” Chicago is a city full of hope, opportunity, and potential for some, but a city plagued with poverty, violence, disinvestment, and hopelessness for others. There has been a significant increase in the awareness of the violence happening across Chicago. The emergence of social media has provided a direct and unfiltered view of the reality of violence the city has faced on an ongoing basis. Crimes such as shootings, …

Origin Of "Shyster" Revisited: Issue Of The Identity Of Cornelius W. Terhune, Gerald Leonard Cohen

Arts, Languages and Philosophy Faculty Research & Creative Works

No abstract provided.

"Insanity Is Smashing Up Against My Soul": The Fifth Circuit And Competency To Be Executed Cases After Panetti V. Quarterman, Michael L. Perlin, Talia Roitberg Harmon

Articles & Chapters

One of the open secrets of death penalty law and policy is the astonishingly high percentage of individuals on death row with serious mental disabilities. This is well known to lawyers who represent this cohort (and presumably, equally well known to the district attorneys who nevertheless prosecute them and the judges who try and sentence them), but is not generally discussed in the press nor, certainly, in political discourse. In the aggregate, this is far beneath society’s radar.

It is now over 14 years since the US Supreme Court decided a case that clarified the underlying issues. In Panetti v. …

The Exclusion Of Public Legal Education From Mandatory And Aspirational State Pro Bono Service Requirements, Amy Wallace

Articles & Chapters

Pro bono service is embedded in legal education and practice. Every year, lawyers and law students across the United States engage in countless hours of pro bono service. There are over 1.3 million lawyers in the country and more than one hundred thousand law students enrolled in law school. Lawyers perform an average of thirty-seven hours of pro bono work each year. They reference several factors that motivate them to perform this work but the desire to help people in need ranks highest. Professional duty is also listed as an important factor for lawyers choosing to perform pro bono work. …

A Judicially Manageable Test To Restore Accountability, David Schoenbrod

Articles & Chapters

No abstract provided.

Prosecutorial Nonenforcement And Residual Criminalization, Justin Murray

Articles & Chapters

In recent years a small but influential group of locally elected prosecutors committed to criminal justice reform have openly refused to enforce various criminal laws—laws prohibiting marijuana possession, sentence enhancements, laws authorizing the death penalty, and much more—because they see those laws as unjust and incompatible with core reform objectives. Condemned by many on the political right for allegedly usurping the legislature’s lawmaking role and praised by many on the left for bypassing dysfunctional state legislatures in favor of local solutions, these prosecutorial nonenforcement policies are commonly said to have the same effect as nullifying, or even repealing, the laws …

Microplastics In The Atmosphere Of Ahvaz City, Iran, Sajjad Abbasi, Neamatollah Jaafarzadeh, Amir Zahedi, Maryam Ravanbakhsh, Somayeh Abbaszadeh, Andrew Turner

School of Geography, Earth and Environmental Sciences

Airborne particulate matter (PM) with an aerodynamic size cutoff of 10 µm (PM10) has been collected using a high volume air sampler at two locations (urban and residential) in the city of Ahvaz, Iran, for sixteen 24-hour periods over four months (late summer to early winter). Microplastics (MPs) in the PM were isolated after sample digestion and were subsequently characterised by established techniques. All MPs sampled (n = 322) were of a fibrous nature, with polyethylene terephthalate, nylon and polypropylene being the dominant polymers and consistent with textiles and fabrics as the principal source. Despite a distinct seasonality (temperature and …

Infection With The Hepatitis C Virus Causes Viral Genotype-Specific Differences In Cholesterol Metabolism And Hepatic Steatosis, David A. Sheridan, Isaac Thom Shawa, E. Louise Thomas, Daniel J. Felmlee, Simon H. Bridge, Dermot Neely, Jeremy F. Cobbold, Elaine Holmes, Margaret F. Bassendine, Simon D. Taylor-Robinson

Peninsula Medical School

Lipids play essential roles in the hepatitis C virus (HCV) life cycle and patients with chronic HCV infection display disordered lipid metabolism which resolves following successful anti-viral therapy. It has been proposed that HCV genotype 3 (HCV-G3) infection is an independent risk factor for hepatocellular carcinoma and evidence suggests lipogenic proteins are involved in hepatocarcinogenesis. We aimed to characterise variation in host lipid metabolism between participants chronically infected with HCV genotype 1 (HCV-G1) and HCV-G3 to identify likely genotype-specific differences in lipid metabolism. We combined several lipidomic approaches: analysis was performed between participants infected with HCV-G1 and HCV-G3, both in …

‘It’S Not Just Music, It Helps You From Inside’: Mixing Methods To Understand The Impact Of Music On Young People In Contact With The Criminal Justice System, L Caulfield, A Jolly, E Simpson, Y Devi-Mcgleish

School of Health Professions

In response to some of the criticisms of previous research into the arts in criminal justice, this article presents findings from research with a music programme run by a Youth Offending team (YOT). Data were collected on the attendance of 42 participants at YOT appointments – matched against a comparison group – and measures of change over time in musical development, attitudes and behaviour and well-being. Participants who completed the music programme were statistically more likely to attend YOT appointments than a comparison group. There were statistically significant improvements in participants’ self-reported well-being and musical ability over the course of …

Visual Perspective Taking Without Visual Perspective Taking, S Samuel

School of Psychology

What happens when an observer takes an agent's visual perspective of a scene? We conducted a series of experiments designed to measure what proportion of adults take a stimulus-centered rather than agent-centered approach to a visual perspective taking task. Adults were presented with images of an agent looking at a number (69). From the perspective of the viewer, the number appeared upside down. We then asked participants what number the agent saw. An agent-centered approach, that is, one that takes into account the other's visual experience, should produce the correct answer "69". Even an egocentric error (i.e., the participant's own …

The Father Of Faith Rationally Reconstructed, Levi Durham

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.

Sucroferric Oxyhydroxide For Hyperphosphatemia: A Review Of Real-World Evidence, Daniel W Coyne, Stuart M Sprague, Marc Vervloet, Rosa Ramos, Kamyar Kalantar-Zadeh

2020-Current year OA Pubs

Hyperphosphatemia is a common complication in dialysis-dependent patients with chronic kidney disease. Most dialysis-dependent patients need oral phosphate binder therapy to control serum phosphorus concentrations. Most phosphate binders have a high daily pill burden, which may reduce treatment adherence and impair phosphorus control. Sucroferric oxyhydroxide is a potent iron-based phosphate binder approved for use in dialysis-dependent patients in 2013. A randomized controlled trial of sucroferric oxyhydroxide demonstrated its efficacy for reduction of serum phosphorus with a lower pill burden than sevelamer carbonate. Clinical trials carefully select patients, monitor adherence, and routinely titrate medications to a protocol-defined goal. Consequently, trials may …

Efficacy And Safety Outcomes With Diroximel Fumarate After Switching From Prior Therapies Or Continuing On Drf: Results From The Phase 3 Evolve-Ms-1 Study, Sibyl Wray, Robert T Naismith, Et Al.

2020-Current year OA Pubs

INTRODUCTION: Diroximel fumarate (DRF) is an oral fumarate for relapsing multiple sclerosis (MS) with the same active metabolite as dimethyl fumarate (DMF). DRF has a safety/efficacy profile similar to DMF but with improved gastrointestinal (GI) tolerability and low (< 1%) treatment discontinuation due to GI adverse events (AEs). Efficacy and safety outcomes in patients who switched to DRF from other disease-modifying therapies (DMTs) have not been evaluated.

METHODS: EVOLVE-MS-1 is an ongoing, 2-year, open-label, phase 3 study of DRF in adults with relapsing-remitting MS. Patients either entered as newly enrolled to DRF trials, or from the 5-week, randomized, head-to-head, phase 3 EVOLVE-MS-2 study of DRF and DMF. This analysis evaluated safety and GI tolerability in patients continuing on DRF (DRF-rollover) or switching from DMF (DMF-rollover) following EVOLVE-MS-2. Safety …

A Study Examining The Usefulness Of A New Measure Of Research Engagement, Deborah J Bowen, Nicole Ackermann, Vetta Saunders Thompson, Andrea Nederveld, Melody Goodman

2020-Current year OA Pubs

INTRODUCTION: Engagement of relevant stakeholders' ideas, opinions, and concerns is critical to the success of modern research projects. We have developed a tool to measure stakeholder engagement, called the Research Engagement Survey Tool (REST). The purpose of this paper is to present the implementation and uptake of the stakeholder engagement measure REST among research teams, including the assessment of barriers and facilitating factors for use of the new research engagement measure in practice.

METHODS: In this implementation study, project team members participated in baseline and follow-up web-based surveys. Web-based interviews were conducted with a subset of project teams that implemented …

Association Of Prenatal Exposure To Early-Life Adversity With Neonatal Brain Volumes At Birth, Regina L Triplett, Rachel E Lean, Amisha Parikh, J Philip Miller, Dimitrios Alexopoulos, Sydney Kaplan, Dominique Meyer, Christopher Adamson, Tara A Smyser, Cynthia E Rogers, Deanna M Barch, Barbara Warner, Joan L Luby, Christopher D Smyser

2020-Current year OA Pubs

Importance: Exposure to early-life adversity alters the structural development of key brain regions underlying neurodevelopmental impairments. The association between prenatal exposure to adversity and brain structure at birth remains poorly understood.

Objective: To examine whether prenatal exposure to maternal social disadvantage and psychosocial stress is associated with neonatal global and regional brain volumes and cortical folding.

Design, Setting, and Participants: This prospective, longitudinal cohort study included 399 mother-infant dyads of sociodemographically diverse mothers recruited in the first or early second trimester of pregnancy and their infants, who underwent brain magnetic resonance imaging in the first weeks of life. Mothers were …

Fluvoxamine For Outpatient Management Of Covid-19 To Prevent Hospitalization: A Systematic Review And Meta-Analysis, Todd C Lee, Simone Vigod, Émilie Bortolussi-Courval, Ryan Hanula, David R Boulware, Eric J Lenze, Angela M Reiersen, Emily G Mcdonald

2020-Current year OA Pubs

Importance: Widely available and affordable options for the outpatient management of COVID-19 are needed, particularly for therapies that prevent hospitalization.

Objective: To perform a meta-analysis of the available randomized clinical trial evidence for fluvoxamine in the outpatient management of COVID-19.

Data Sources: World Health Organization International Clinical Trials Registry Platform and ClinicalTrials.gov.

Study Selection: Studies with completed outpatient trials with available results that compared fluvoxamine with placebo were included.

Data Extraction and Synthesis: The PRISMA 2020 guidelines were followed and study details in terms of inclusion criteria, trial demographics, and the prespecified outcome of all-cause hospitalization were extracted. Risk of …

Association Between Self-Reported Body Mass Index And Active Life Expectancy In A Large Community-Dwelling Sample Of Older U.S. Adults, Haomiao Jia, Erica I. Lubetkin

Publications and Research

Background: Obesity may have a protective effect (greater survival) in older adults, a finding known as the "obesity paradox." This study examined the association between self-reported body mass index (BMI) and active life expectancy (ALE) among older U.S. adults.

Methods: Using the Medicare Health Outcomes Survey Cohort 15 (2012 baseline, 2014 follow-up), we estimated life expectancy and ALE by participants' baseline BMI and age using multi-state models. A participant was classified as in an active state if this person reported having no difficulty for any of these six activities of daily living (ADLs).

Results: Small differences in life expectancy were …

Gen-Z, Gender, & Governmental Grievances: A Post-Transition Political Philosophy For The Newest Generation Of Women In A ‘Failed’ State., Olivia Harvey

Independent Study Project (ISP) Collection

Over a decade since the Jasmine Revolution in Tunisia, a new generation has come into adulthood, grappling with anxieties about their future in the midst of continuous national instability. This paper aims to bridge their sentiments of disillusionment and disengagement towards politics together with general conceptions of life by ‘Generation-Z’ women (between the ages of 18 and 30). The findings follow conceptions of history, freedoms, rights and personal life, particularly as they are affected by gender in Tunisian society. Specifically, this study is interested in how these aspects have changed from before to after the political changes of the past …

“Somos Un Pueblo Fumigado”: Un Análisis De La Lucha Contra La Fumigación Y Sistema De Agronegocios En La Provincia De Buenos Aires, Samuel Brooks

Independent Study Project (ISP) Collection

Esta investigación estudia el movimiento contra el sistema de monocultivo de soja transgénica, la fumigación con “agrotóxicos,” y los grandes agronegocios en la provincia de Buenos Aires. Con la información de tres entrevistas y una visita a un encuentro de habitantes de pueblos fumigados, examino los diferentes “marcos” que el movimiento tiene para describir las formas en que ellos expresan el problema actual, las soluciones que proponen, sus métodos para motivar a la gente, y la perspectiva del movimiento en general. También, incorporo perspectivas académicas para profundizar el análisis de las diferentes áreas de discurso en el movimiento y definir …

Duelos Incompletos: La Situación Actual Del Acceso A Servicios De Salud Mental Para Los Sobrevivientes Del Conflicto Armado En Ayacucho, Olivia Frison De Angelis

Independent Study Project (ISP) Collection

La salud mental es un asunto relativamente nuevo en el Perú. En la ciudad andina de Ayacucho en la provincia de Huamanga, el gobierno solamente empezó a financiar proyectos de salud mental accesibles a las comunidades campesinas en los últimos seis años, desde 2016. Considerando que la región de Ayacucho ha sufrido el número más alto de muertes y desaparecidos durante el conflicto armado interno de 1980 hasta 2000, es atroz que estas medidas han empezado tan tarde. Entretanto, mientras que las conversaciones avanzan sobre cómo seguir haciendo reparaciones de salud mental a los sobrevivientes del conflicto, ellos siguen con …

La Política Cultural Del Aborto: Las Percepciones Y El Manejo Del Aborto En Arica, Chile, Eva Strelitz-Block

Independent Study Project (ISP) Collection

Chile has a long history of restricting access to legal abortion. Until 2017, when the government passed the law N° 21.030 decriminalizing abortion on three grounds, abortion was completely illegal. However, despite this movement towards decriminalization, legal abortion access is still very limited and highly restricted. In this criminalized, highly stigmatized environment, self-managed abortion has emerged as a way to transform the landscape of abortion. This qualitative, exploratory study seeks to explore perceptions of abortion and practices of abortion management both within and outside of the official healthcare system among women and people with the capacity to become pregnant and …

Conservation And Variation In Agricultural Landscapes: A Survey Of Insect Populations Across Naranjilla Cultivation Methods In The Eastern Andean Cloud Forest, Ian Zakelj

Independent Study Project (ISP) Collection

This study compared insect biodiversity among five sites in agricultural landscapes and natural forest in the El Placer community in the valley of the Rio Pastaza in the eastern Andean cloud forest. The area is of vital importance to conservation, as it falls in the ecological corridor between the Sangay and Llanganates national parks. The primary crop produced by the residents of El Placer is naranjilla, and it is cultivated in a variety of manners, mostly with intensive chemical use. The goal of the study was to find out which types of practices were the least harmful to the insect …

Water: The Gift And The Curse: A Climate Change Preparedness Study On An Increased Rainfall Scenarios In The Yunguilla Cloud Forest, Ecuador, Emilia Dick Fiora Del Fabro

Independent Study Project (ISP) Collection

The purpose of this project was to try and better understand the risks posed to the Yunguilla community in an increased rainfall climate change scenario. While climate modeling is not exact, many models do predict increased rain and storm intensity in this area (“Explainer…”, 2018). This project studies erosion risk, and the potential damage to crops through a series of experiments and mapping.

The first experiment used three hydration percentages 50, 75 and 100, to water two crop types, Fragaria and Caspium, and monitored plant health to see the water's effect. The hydraulic stress testing did not model an increased …

A Displaced People: Documenting The History And Displacement Of The Batwa Tribe In Bundibugyo District, Uganda., Marcos S. Turk

Independent Study Project (ISP) Collection

The Batwa in Bundibugyo are an indigenous minority group that originated in the forest of the Democratic Republic of Congo. Since then, various displacement factors have taken effect that have forced them out of the forest. Currently they live in Bundibugyo District, Uganda. This study aimed at identifying those displacement factors while also investigating Batwa history and culture as they are a relatively undocumented group. The Batwa have various traditions they established while in the forest, such as unique methods for hunting forest animals. Because Uganda forced them out of the forest, many of their cultural practices no longer occur. …

Good Cop/Bad Cop: A Comparative Analysis Of Affiliative And Aggressive Behaviors By Adult Female And Male Olive Baboons With Infants At Randilen Wildlife Management Area, Tanzania, Jesse Elop

Independent Study Project (ISP) Collection

This study investigated the infant-directed behaviors of adult male and female olive baboons in Randilen Wildlife Management Area in April of 2022. The objectives were 1) To determine the difference between olive baboon males and females in frequency and duration of listed behaviors towards infants; 2) To classify the interactions of adult male and adult female olive baboons with infants as either primarily affiliative or primarily aggressive; 3) To determine the frequency of selected behaviors at different reproductive phases (lactation, estrus, neutral, indeterminant) amongst female olive baboons towards infants. A single baboon troop in Randilen Wildlife Management Area was observed …

Worrying In Cato Manor: A Case Study Analysis On The Influence Of Context, Samantha Garbus

Independent Study Project (ISP) Collection

Social Causation theory states that social and economic circumstances cause people to be at a higher risk of mental illness (Lund 2011, p.1). South Africa has high inequality, with racial disparities prevalent in multiple indicators of socioeconomic status. Moreover, mental health in South Africa has often not been prioritized. This project aimed to assess how context impacts relevant aspects of mental health, such as worrying and the mind/body stress-response in Cato Manor. An additional theme of community beliefs on stress emerged from the interviews which is also presented.

For this project, I used a Mixed Methods-Case Study research design. I …