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Articles 329011 - 329040 of 1794698
Full-Text Articles in Entire DC Network
Midweek Memo, Georgia Southern University
Midweek Memo, Georgia Southern University
Midweek Memo
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Tell Me More: Parent–Child Sexual Talk And Young Adult Sexual Communication Satisfaction With Romantic Partners, Kelsi N. Wilson, Jakob Jensen, Sharon Ballard, Alan Taylor
Tell Me More: Parent–Child Sexual Talk And Young Adult Sexual Communication Satisfaction With Romantic Partners, Kelsi N. Wilson, Jakob Jensen, Sharon Ballard, Alan Taylor
Journal of Social, Behavioral, and Health Sciences
Young adults (18–30) tend to show insufficient levels of communication about sex with their romantic partners, despite its many benefits to relationships among this age group. Learned sexual shame and guilt can play a role in inhibiting sexual communication with partners, and early messages about sex from parents stemming from narrow cultural boundaries of communication may play a role in fostering sexual shame and guilt from a young age, potentially influencing later sexual communication patterns with partners. We sought to identify whether a significant relationship existed between the sexual communication participants received from parents while growing up and their current …
Research Communities And Institutional Resilience Amidst The Covid-19 Pandemic, Joseph Ching Velasco
Research Communities And Institutional Resilience Amidst The Covid-19 Pandemic, Joseph Ching Velasco
Asia-Pacific Social Science Review
No abstract provided.
Narratives Of Structural And Cultural Violence In The Context Of The Stateless Hill Tribes Living With Hiv/ Aids In Chiang Rai, Thailand, Pilasinee Wongnuch, Thapakorn Ruanjai, Anongnad Mee-Inta, Chadaporn Inta, Tawatchai Apidechkul, Rattipark Tamornpark, Panupong Upala, Chalitar Chomchoei, Phitnaree Thutsanti
Narratives Of Structural And Cultural Violence In The Context Of The Stateless Hill Tribes Living With Hiv/ Aids In Chiang Rai, Thailand, Pilasinee Wongnuch, Thapakorn Ruanjai, Anongnad Mee-Inta, Chadaporn Inta, Tawatchai Apidechkul, Rattipark Tamornpark, Panupong Upala, Chalitar Chomchoei, Phitnaree Thutsanti
Asia-Pacific Social Science Review
Stateless hill tribes living with HIV/AIDS are the most vulnerable population in Thailand. This article adopts the issue of the structural and cultural violence of Johan Galtung as a conceptual framework and analytical tool to narrate their experiences. Data encompassing the experiences of structural and cultural violence were collected from the 53 eligible stateless hill tribes living with HIV/AIDS recruited from 10 district hospitals and 15 communities in Chiang Rai, Thailand, using a combination of the snowball technique and purposive sampling. The present authors argue that the stateless hill tribes living with HIV/AIDS mainly experienced the following two dimensions of …
Moral Right To Healthcare And Covid-19 Challenges, Napoleon M. Mabaquiao Jr., Mark Anthony L. Dacela
Moral Right To Healthcare And Covid-19 Challenges, Napoleon M. Mabaquiao Jr., Mark Anthony L. Dacela
Asia-Pacific Social Science Review
One fundamental healthcare issue brought to the fore by the current COVID-19 pandemic concerns the scope and nature of the right to healthcare. Given our increasing need for the usually limited healthcare resources, to what extent can we demand provision of these resources as a matter of right? One philosophical way of handling this issue is to clarify the nature of this right. Using the challenges of COVID-19 in the Philippines as the context of analysis, we argue for the view that regards the right to healthcare as fundamentally moral in kind, which should thereby guide its legal and contractual …
Extracurricular Activity Involvement On The Compassion, Academic Competence, And Commitment Of Collegiate Level Students: A Structural Equation Model, Imary Frances Boy, Mark Angelo A. Bondoc, Cheska Alyssandra Q. Bonifacio, Ma. Daniella R. Bonoan, Rica Coleen Bonoan, John Rey B. Macindo, Gian Carlo S. Torres
Extracurricular Activity Involvement On The Compassion, Academic Competence, And Commitment Of Collegiate Level Students: A Structural Equation Model, Imary Frances Boy, Mark Angelo A. Bondoc, Cheska Alyssandra Q. Bonifacio, Ma. Daniella R. Bonoan, Rica Coleen Bonoan, John Rey B. Macindo, Gian Carlo S. Torres
Asia-Pacific Social Science Review
Extracurricular activities (ECAs) performed outside the realm of a student’s academic activities such as sports, drama, music, and dance play an integral part in their educational experience and positive youth development. Nevertheless, there is a paucity of studies exploring the interrelationship of ECA involvement on the compassion, academic competence, and commitment of collegiate students. Hence, this study determined the influence of ECA involvement on the compassion, academic competence, and commitment of collegiate students. Employing a covariance-based structural equation modeling, a descriptive-correlational design was conducted among 365 consenting collegiate students who completed standardized instruments to measure their ECAs profile, compassion, academic …
A Comparative Examination Of Disaster Organizations In The Philippines, South Korea, And The United States, Junmo Kim, Seung-Bum Yang, Ador R. Torneo
A Comparative Examination Of Disaster Organizations In The Philippines, South Korea, And The United States, Junmo Kim, Seung-Bum Yang, Ador R. Torneo
Asia-Pacific Social Science Review
The Philippines is highly vulnerable to weather-related and other natural disasters given its location in the Pacific Ring of Fire. Its disaster organization, the National Disaster Risk Reduction and Management Council or NDRRMC, however, has limited capacity, as demonstrated in its handling of natural disasters in the last 20 years. In this paper, we adopt a comparative approach and compare the NDRRMC with the U.S. Federal Emergency Management Agency (FEMA) and South Korea’s Disaster and Safety Management (DSM) in terms of mandate, organizational structure, resources, and technical capacity to identify possible areas requiring reform. We observe that the NDRRMC’s working …
Age, Covid-19, And Mental Health In The Philippines: A Multidimensional Perspective, Hechanova Ma. Regina, Alvin Patrick Valentin, Karlos Pio Alampay
Age, Covid-19, And Mental Health In The Philippines: A Multidimensional Perspective, Hechanova Ma. Regina, Alvin Patrick Valentin, Karlos Pio Alampay
Asia-Pacific Social Science Review
The COVID-19 pandemic has caused many to become isolated, increased feelings of loneliness, and given rise to mental health issues. Using the Transactional Theory of Stress and Coping, this study looked at the predictors of mental health outcomes during the COVID-19 pandemic across age groups. Results showed that COVID-19 stressors, resilience, nonreactivity, and coping behaviors predicted stress, anxiety, depression, and psychological well-being. Cluster analysis revealed two age clusters—those between 16 and 35 years and those 36 years and above. The younger group reported greater depression, anxiety, and stress symptoms and poorer psychological well-being compared to the older group. The younger …
إمكانية تطبيق الاستدامة المالية في ظل مخاطر الدين العام في العراق, عقيل حميد الحلو, ام البنين حميد الجياشي
إمكانية تطبيق الاستدامة المالية في ظل مخاطر الدين العام في العراق, عقيل حميد الحلو, ام البنين حميد الجياشي
Muthanna Journal of Administrative and Economics Sciences
ينطلق موضوع البحث من الأهمية القصوى للاستدامة المالية وإمكانية تحققها في ظل مخاطر الدين العام في العراق، لاسيما في ظل الأزمات والصعوبات الإقتصادية، وتدور مشكلة البحث حول أثر إرتفاع المديونية العامة على إمكانية تحقق الاستدامة المالية في العراق ولتحقق هدف البحث تم أستخدام التحليل الوصفي الأحصائي للتحقق من إمكانات الاستدامة المالية وأثر إستخدامها للحد من مشاكل مخاطر الدين العام، وتحليل مؤشرات الدين العام في العراق للمدة قيد الدراسة، وتوصل البحث إلى جملة من الأسباب أهمها أن مؤشرات الدين العام تشير إلى أن العراق لم يصل إلى مرحلة الخطر وفقاً للمعايير الدولية، ألا أن وجود الدين العام في ظل الأزمة المالية …
Organizational Capabilities And Their Role In Enhancing Of The Organizational Immune System Analytical Study In The Iraqi Insurance Company, Jinan Jinan Shihab Ahmed
Organizational Capabilities And Their Role In Enhancing Of The Organizational Immune System Analytical Study In The Iraqi Insurance Company, Jinan Jinan Shihab Ahmed
Muthanna Journal of Administrative and Economics Sciences
Purpose of study: The effectiveness of organizational capabilities as a method for enhancing the functioning of the organizational immune system was investigated in this research. Methodology: A field research was carried out at an Iraqi insurance business with (150) personnel. This study was utilized to evaluate and answer all of the research questions using a quantitative method. Then, using hierarchical regression analysis with SPSS as an analysis tool, hypotheses for direct effects are tested(127) surveys valid for analysis. Result: According to the findings, there is a link between organizational capabilities and organizational immune system functions in the research community. Recommendations: …
Analysis Of Pelvic Bone Of Ovariectomized Rats Using Infrared And Raman Spectroscopies, Nurwentari Dyah Fitriyawardhani, Ariadne Lakshmidevi Juwono, Neng Nenden Mulyaningsih
Analysis Of Pelvic Bone Of Ovariectomized Rats Using Infrared And Raman Spectroscopies, Nurwentari Dyah Fitriyawardhani, Ariadne Lakshmidevi Juwono, Neng Nenden Mulyaningsih
Makara Journal of Science
Osteoporosis is a bone disease that generally occurs in postmenopausal women. Osteoporosis can be studied using an animal model such as rats because rat bone structure is similar to human bone structure. This research aimed to analyze pelvic bones of ovariectomized rats that showed osteoporosis signs for the first time. In this study, 20 Rattus norvegicus were given ovariectomy at 12 weeks of age and were used as an animal model for menopausal women. The rats were euthanized every 2 weeks from 13 to 21 weeks of age. In addition, the pelvic bones of ovariectomized rats will be analyzed using …
Efficacy Of Tuberculosis Vaccine Candidate Pcdna3.1-Rpfb In Inhibiting The Growth Of Mycobacterium Tuberculosis In Vitro With Mycobacterial Growth Inhibition Assay, Ratih Pujilestari, Andriansjah Rukmana, Anis Karuniawati
Efficacy Of Tuberculosis Vaccine Candidate Pcdna3.1-Rpfb In Inhibiting The Growth Of Mycobacterium Tuberculosis In Vitro With Mycobacterial Growth Inhibition Assay, Ratih Pujilestari, Andriansjah Rukmana, Anis Karuniawati
Makara Journal of Science
Tuberculosis (TB) is caused by Mycobacterium tuberculosis (Mtb). Bacille Calmette-Guérin (BCG) is the only licensed vaccine against TB, and it is effective in children but not in adults. The Vaccine Research Team, Department of Microbiology FKUI has developed a DNA-based TB vaccine candidate pcDNA3.1-rpfB. This candidate induces immune responses in mice, but its potency is unknown. The gold standard for potency testing of TB vaccine is the challenge method. The BSL3 animal laboratory for the challenge method is currently unavailable at FKUI. Therefore, mycobacterial growth inhibition assay (MGIA) was used as a preliminary test before the in vivo …
Evaluation Of Nitrite Concentration In Edible Bird’S Nest (White, Yellow, Orange, And Red Blood), Siti Gusti Ningrum, Bagus Uda Palgunad, Rochiman Sasmita
Evaluation Of Nitrite Concentration In Edible Bird’S Nest (White, Yellow, Orange, And Red Blood), Siti Gusti Ningrum, Bagus Uda Palgunad, Rochiman Sasmita
Makara Journal of Science
The color of edible bird’s nest is associated with its nitrite concentration, but this relationship remains inconclusive. This investigation aimed to evaluate the nitrite content in edible bird’s nest of four different colors: white, yellow, orange, and red blood. Fifty-eight edible bird’s nest samples were obtained from five swiftlet farmhouses in Borneo Island, Indonesia and analyzed for nitrite content using Genesys 30 visible spectrophotometer. Results showed that the dark-colored edible bird’s nests (yellow, orange, and red blood) had higher nitrite concentrations of 304, 317, and 309 ppm, respectively, compared with the white-colored one (15 ppm). Therefore, the color of edible …
Effects Of Water Scarcity On Rural Household Economy, Adam Ahmed Sabbil, Badreldin Mohamed Abdulrahman
Effects Of Water Scarcity On Rural Household Economy, Adam Ahmed Sabbil, Badreldin Mohamed Abdulrahman
Journal of Economics and Administrative Sciences
This study examined the effects of water scarcity on rural household economy in El Fashir Rural Council / North Darfur State- western Sudan. Both quantitative and qualitative methods were used as to get a deeper understanding of the impact of water scarcity on the rural house economy in the study area. 174 households out of 2017 were selected from 45 villages which were distributed in eight village councils forming the study area. Statistical methods were used to manipulate the data of the study. The obtained results revealed that water scarcity negatively affected the rural household economy in the study area …
Industrial Development Strategy Until 2030, Adel Ghazi Al- Hayaly
Industrial Development Strategy Until 2030, Adel Ghazi Al- Hayaly
Journal of Economics and Administrative Sciences
The research is a vision of the future of industry in Iraq, so it is may be outside the ceiling of the capabilities of the Iraqi economy, and therefore it is exaggerated. Therefore, future plans must be applicable through the availability of capabilities. Everyone knows that the financial and administrative corruption and mismanagement of resources are the main cause of the inefficiency of the industrial sector, and the failure to exercise its real role in achieving economic development.; as well as the political situation and the dominance of parties and their insistence on addressing positions that have a strong relationship …
The Decent Work Impact In Enhancing Job Immersion/ An Applied Research In Labour And Vocational Training Directorate, Areej Saeed Khaleel, Zahraa Abbas Ali Hussen
The Decent Work Impact In Enhancing Job Immersion/ An Applied Research In Labour And Vocational Training Directorate, Areej Saeed Khaleel, Zahraa Abbas Ali Hussen
Journal of Economics and Administrative Sciences
The research aims to identify decent work and its impact in enhancing job immersion. The questionnaire was adopted as a tool to analyze the sample responses of (81) workers to represent an estimated response rate of (88 per cent) out of the total population of (92) individuals. The research adopted descriptive-analytical approach, and reliability calculation, arithmetic means standard deviations, relative importance, and regression analysis adopted on SPSS v.25. The conclusion shows that there is a medium correlation between decent work and job immersion, and there is a low impact of decent work with its dimensions in job immersion; extract the …
Mutations Of The Dna Repair Gene Pnkp In A Patient With Microcephaly, Seizures, And Developmental Delay (Mcsz) Presenting With A High-Grade Brain Tumor, Bingcheng Jiang, Cameron Murray, Bonnie L Cole, J N Mark Glover, Gordon K Chan, Jean Deschenes, Rajam S Mani, Sudip Subedi, John D Nerva, Anthony C Wang, Christina M Lockwood, Heather C Mefford, Sarah E S Leary, Jeffery G Ojemann, Michael Weinfeld, Chibawanye I Ene
Mutations Of The Dna Repair Gene Pnkp In A Patient With Microcephaly, Seizures, And Developmental Delay (Mcsz) Presenting With A High-Grade Brain Tumor, Bingcheng Jiang, Cameron Murray, Bonnie L Cole, J N Mark Glover, Gordon K Chan, Jean Deschenes, Rajam S Mani, Sudip Subedi, John D Nerva, Anthony C Wang, Christina M Lockwood, Heather C Mefford, Sarah E S Leary, Jeffery G Ojemann, Michael Weinfeld, Chibawanye I Ene
Faculty, Staff and Student Publications
Polynucleotide Kinase-Phosphatase (PNKP) is a bifunctional enzyme that possesses both DNA 3'-phosphatase and DNA 5'-kinase activities, which are required for processing termini of single- and double-strand breaks generated by reactive oxygen species (ROS), ionizing radiation and topoisomerase I poisons. Even though PNKP is central to DNA repair, there have been no reports linking PNKP mutations in a Microcephaly, Seizures, and Developmental Delay (MSCZ) patient to cancer. Here, we characterized the biochemical significance of 2 germ-line point mutations in the PNKP gene of a 3-year old male with MSCZ who presented with a high-grade brain tumor (glioblastoma multiforme) within the cerebellum. …
A Blockchain Secured Pharmaceutical Distribution System To Fight Counterfeiting, Kavyan Zoughalian, Jims Marchang, Bogdan Ghita
A Blockchain Secured Pharmaceutical Distribution System To Fight Counterfeiting, Kavyan Zoughalian, Jims Marchang, Bogdan Ghita
School of Engineering, Computing and Mathematics
Counterfeiting drugs has been a global concern for years. Considering the lack of transparency within the current pharmaceutical distribution system, research has shown that blockchain technology is a promising solution for an improved supply chain system. This study aims to explore the current solution proposals for distribution systems using blockchain technology. Based on a literature review on currently proposed solutions, it is identified that the secrecy of the data within the system and nodes’ reputation in decision making has not been considered. The proposed prototype uses a zero-knowledge proof protocol to ensure the integrity of the distributed data. It uses …
Geotemporospatial And Causal Inferential Epidemiological Overview And Survey Of Usa Cannabis, Cannabidiol And Cannabinoid Genotoxicity Expressed In Cancer Incidence 2003–2017: Part 1 - Continuous Bivariate Analysis, Albert Stuart Reece, Gary Kenneth Hulse
Geotemporospatial And Causal Inferential Epidemiological Overview And Survey Of Usa Cannabis, Cannabidiol And Cannabinoid Genotoxicity Expressed In Cancer Incidence 2003–2017: Part 1 - Continuous Bivariate Analysis, Albert Stuart Reece, Gary Kenneth Hulse
Research outputs 2022 to 2026
Background
The genotoxic and cancerogenic impacts of population-wide cannabinoid exposure remains an open but highly salient question. The present report examines these issues from a continuous bivariate perspective with subsequent reports continuing categorical and detailed analyses.
Methods
Age-standardized state census incidence of 28 cancer types (including “All (non-skin) Cancer”) was sourced using SEER*Stat software from Centres for Disease Control and National Cancer Institute across US states 2001–2017. It was joined with drug exposure data from the nationally representative National Survey of Drug Use and Health conducted annually by the Substance Abuse and Mental Health Services Administration 2003–2017, response rate 74.1%. …
Geotemporospatial And Causal Inferential Epidemiological Overview And Survey Of Usa Cannabis, Cannabidiol And Cannabinoid Genotoxicity Expressed In Cancer Incidence 2003–2017: Part 2 – Categorical Bivariate Analysis And Attributable Fractions, Albert Stuart Reece, Gary Kenneth Hulse
Geotemporospatial And Causal Inferential Epidemiological Overview And Survey Of Usa Cannabis, Cannabidiol And Cannabinoid Genotoxicity Expressed In Cancer Incidence 2003–2017: Part 2 – Categorical Bivariate Analysis And Attributable Fractions, Albert Stuart Reece, Gary Kenneth Hulse
Research outputs 2022 to 2026
Background: As the cannabis-cancer relationship remains an important open question epidemiological investigation is warranted to calculate key metrics including Rate Ratios (RR), Attributable Fractions in the Exposed (AFE) and Population Attributable Risks (PAR) to directly compare the implicated case burden between emerging cannabinoids and the established carcinogen tobacco. Methods: SEER*Stat software from Centres for Disease Control was used to access age-standardized state census incidence of 28 cancer types (including “All (non-skin) Cancer”) from National Cancer Institute in US states 2001–2017. Drug exposures taken from the National Survey of Drug Use and Health 2003–2017, response rate 74.1%. Federal seizure data provided …
An Investigation Of A Novel Broad Autism Phenotype: Increased Facial Masculinity Among Parents Of Children On The Autism Spectrum, Diana Weiting Tan, Syed Zulqarnain Gilani, Gail A. Alvares, Ajmal Mian, Andrew J. O. Whitehouse, Murray T. Maybery
An Investigation Of A Novel Broad Autism Phenotype: Increased Facial Masculinity Among Parents Of Children On The Autism Spectrum, Diana Weiting Tan, Syed Zulqarnain Gilani, Gail A. Alvares, Ajmal Mian, Andrew J. O. Whitehouse, Murray T. Maybery
Research outputs 2022 to 2026
The broad autism phenotype commonly refers to sub-clinical levels of autistic-like behaviour and cognition presented in biological relatives of autistic people. In a recent study, we reported findings suggesting that the broad autism phenotype may also be expressed in facial morphology, specifically increased facial masculinity. Increased facial masculinity has been reported among autistic children, as well as their non-autistic siblings. The present study builds on our previous findings by investigating the presence of increased facial masculinity among non-autistic parents of autistic children. Using a previously established method, a 'facial masculinity score' and several facial distances were calculated for each three-dimensional …
Geotemporospatial And Causal Inferential Epidemiological Overview And Survey Of Usa Cannabis, Cannabidiol And Cannabinoid Genotoxicity Expressed In Cancer Incidence 2003–2017: Part 3 – Spatiotemporal, Multivariable And Causal Inferential Pathfinding And Exploratory Analyses Of Prostate And Ovarian Cancers, Albert Stuart Reece, Gary Kenneth Hulse
Geotemporospatial And Causal Inferential Epidemiological Overview And Survey Of Usa Cannabis, Cannabidiol And Cannabinoid Genotoxicity Expressed In Cancer Incidence 2003–2017: Part 3 – Spatiotemporal, Multivariable And Causal Inferential Pathfinding And Exploratory Analyses Of Prostate And Ovarian Cancers, Albert Stuart Reece, Gary Kenneth Hulse
Research outputs 2022 to 2026
Background: The epidemiology of cannabinoid-related cancerogenesis has not been studied with cutting edge epidemiological techniques. Building on earlier bivariate papers in this series we aimed to conduct pathfinding studies to address this gap in two tumours of the reproductive tract, prostate and ovarian cancer. Methods: Age-standardized cancer incidence data for 28 tumour types (including “All (non-skin) Cancer”) was sourced from Centres for Disease Control and National Cancer Institute using SEER*Stat software across US states 2001–2017. Drug exposure was sourced from the nationally representative household survey National Survey of Drug Use and Health conducted annually by the Substance Abuse and Mental …
Brown V. The Wavecrest Management Team Ltd.
Brown V. The Wavecrest Management Team Ltd.
All Decisions
A stipulation of settlement that is so-ordered by a judge can be the basis of a finding of civil contempt. Tenants provided prima facie evidence that a number of conditions listed in the stipulation were cited as violations and were not corrected. Tenants' motion is granted to the extent that a hearing will be held at which time tenants must prove that they are entitled to relief including contempt, further order to correct, civil penalties, and attorney's fees.
Matter Of Mutual Apts., Inc. V. New York City Commn. On Human Rights
Matter Of Mutual Apts., Inc. V. New York City Commn. On Human Rights
All Decisions
No abstract provided.
Measuring The Impacts Of Maternal Child Marriage And Maternal Intimate Partner Violence And The Moderating Effects Of Proximity To Conflict On Stunting Among Children Under 5 In Post-Conflict Sri Lanka, Ruvani W. Fonseka, Lotus Mcdougal, Anita Raj, Elizabeth Reed, Rebecka Lundgren, Lianne Urada, Jay G. Silverman
Measuring The Impacts Of Maternal Child Marriage And Maternal Intimate Partner Violence And The Moderating Effects Of Proximity To Conflict On Stunting Among Children Under 5 In Post-Conflict Sri Lanka, Ruvani W. Fonseka, Lotus Mcdougal, Anita Raj, Elizabeth Reed, Rebecka Lundgren, Lianne Urada, Jay G. Silverman
Faculty Research, Scholarly, and Creative Activity
This study aimed to understand whether maternal child marriage and past year intimate partner violence (IPV) impact stunting among Sri Lankan children under 5 years old, and, secondarily, whether proximity to conflict is associated with stunting. Additionally, we assessed whether proximity to conflict moderates the relationships between maternal child marriage and past year IPV (sexual, physical, and emotional). We tested these questions using logistic regression analyses of the 2016 Sri Lankan Demographic and Health Survey (n = 4941 mother-child dyads). In country-wide adjusted analyses, we did not find associations between maternal child marriage or IPV and stunting (p > 0.05). Children …
Establishment Of A Melanoma Esc-Gemm Platform And Its Use To Study Pten Tumor Suppressor Functions, Ilah Bok
Establishment Of A Melanoma Esc-Gemm Platform And Its Use To Study Pten Tumor Suppressor Functions, Ilah Bok
USF Tampa Graduate Theses and Dissertations
The cumbersome and time-consuming process of generating new mouse strains and multiallelic experimental animals often hinders the use of genetically engineered mouse models (GEMM) in cancer research. In chapter 2, we describe the development and validation of an embryonic stem cell (ESC)-GEMM platform for rapid modeling of melanoma in mice. The platform incorporates 12 clinically relevant genotypes composed of combinations of four driver alleles (LSL-BrafV600E, LSL-NrasQ61R, PtenFlox, and Cdkn2aFlox) and regulatory alleles to spatiotemporally control the perturbation of genes of interest. The ESCs produce high-contribution chimeras, which recapitulate the melanoma phenotypes of conventionally bred mice. Using the ESC-GEMM platform to …
Defining And Modeling Pericyte-Induced Capillary Network Assembly, Capillary Regression Preceding Pericyte-Stimulated Fibrosis, And Lymphatic Capillary Regression, Scott Stephen Kemp
Defining And Modeling Pericyte-Induced Capillary Network Assembly, Capillary Regression Preceding Pericyte-Stimulated Fibrosis, And Lymphatic Capillary Regression, Scott Stephen Kemp
USF Tampa Graduate Theses and Dissertations
Capillary formation and maturation can only occur through a series of highly orchestrated events that requires the coordinated efforts of both endothelial cells (ECs) and pericytes. While ECs are perfectly capable of creating tube networks on their own, the maturation and stabilization of these tube networks require the presence of a second cell type, pericytes, to create stable capillary networks. Previous studies have identified factors required for pericyte recruitment to EC tube networks, however, we hypothesized that there were still unaccounted for EC-derived molecules that were contributing to pericyte recruitment. In the first part of this study, we used serum-free, …
Targeting The Side-Chain Convergence Of Α-Helical Hot Spots To Design Small-Molecule Mimetics Disrupting Protein-Protein Interaction, Zhen Wang
USF Tampa Graduate Theses and Dissertations
α-Helix accounts for the largest class of protein secondary structures and plays a key role in mediating protein-protein interactions (PPIs). Small-molecule α-helix mimetics mimic the structural features of α-helical hot spots and offer a powerful tool to unravel complex signaling networks and mitigate aberrant PPIs. In this dissertation, the side-chain conformational convergence of α-helical hot spots was disclosed, and insights into the side-chain convergence were exploited to instruct the design of small-molecule α-helix mimetics. The first chapter of this dissertation provides an overview of the characteristics of α-helical hot spots and current strategies to design small-molecule α-helix mimetics. In chapter …
Re-Centering And De-Centering ‘Race’: An Analysis Of Direct-To-Consumer Genetic Testing Organizational Websites, Beatriz Nieto-Fernandez
Re-Centering And De-Centering ‘Race’: An Analysis Of Direct-To-Consumer Genetic Testing Organizational Websites, Beatriz Nieto-Fernandez
USF Tampa Graduate Theses and Dissertations
As direct-to-consumer (DTC) genetic testing technologies become an ever-expanding business in the United States, this dissertation project investigates the ways in which two leading organizations, AncestryDNA and 23andMe, utilize discourses of ‘race’ to connect with their customers. This study is particularly significant because it opens up new avenues of research in the field of organizational communication by engaging with a new genre of organizations and the complexities of biocapitalism, in which genetic data is commodified for consumption. Blending computational scraping of data and manual qualitative analysis of organizational texts and videos available on the corporate websites, while using postcolonial studies …
Cistrome And Transcriptome Analysis Identifies Unique Androgen Receptor (Ar) And Ar-V7 Splice Variant Chromatin Binding And Transcriptional Activities, Paul Basil, Matthew J Robertson, William E Bingman, Amit K Dash, William C Krause, Ayesha A Shafi, Badrajee Piyarathna, Cristian Coarfa, Nancy L Weigel
Cistrome And Transcriptome Analysis Identifies Unique Androgen Receptor (Ar) And Ar-V7 Splice Variant Chromatin Binding And Transcriptional Activities, Paul Basil, Matthew J Robertson, William E Bingman, Amit K Dash, William C Krause, Ayesha A Shafi, Badrajee Piyarathna, Cristian Coarfa, Nancy L Weigel
Faculty, Staff and Students Publications
The constitutively active androgen receptor (AR) splice variant, AR-V7, plays an important role in resistance to androgen deprivation therapy in castration resistant prostate cancer (CRPC). Studies seeking to determine whether AR-V7 is a partial mimic of the AR, or also has unique activities, and whether the AR-V7 cistrome contains unique binding sites have yielded conflicting results. One limitation in many studies has been the low level of AR variant compared to AR. Here, LNCaP and VCaP cell lines in which AR-V7 expression can be induced to match the level of AR, were used to compare the activities of AR and …