Digital Commons Network^™

Protect Your Patients And Yourself: The Complete And Honest Medical History, Mitchell Gardiner Dmd

The Journal of the Michigan Dental Association

This feature article emphasizes the critical role of obtaining a complete and honest medical history in dental practice. Reflecting on the evolution of clinicians' diligence since dental school, the article underscores the potential risks associated with inadequate medical histories. The legal and ethical responsibilities in gathering comprehensive patient information are highlighted, emphasizing the impact on patient well-being and the dentist's vulnerability to legal challenges. The complexities of patients' truthfulness, especially regarding sensitive topics, are discussed, urging clinicians to establish trust for accurate disclosures. The article concludes with practical recommendations, stressing the ongoing need for thorough medical history reviews and the …

Lower The Risk For Medical Emergencies, Christopher J. Smiley Dds

The Journal of the Michigan Dental Association

Clinicians focus on health and safety for our patients. The editorial highlights the importance of cultural competence in dentistry to mitigate the risk of medical emergencies. Reflecting on a recent CE program, Dr. Smiley underscores the need for proactive emergency preparedness, emphasizing detailed protocols and hands-on training. The article advocates for thorough patient screening, incorporating three questions presented by Dr. Mitchel Gardiner in an article in this month’s issue, addressing patient-specific health considerations and consulting with healthcare providers. The editorial concludes by stressing the significance of risk reduction through comprehensive assessments, team training, and preparedness.

News You Need: Reminder: What You Must Know About Antitrust Law, Dan Schulte Jd

The Journal of the Michigan Dental Association

This reminder emphasizes the critical importance for dentists, particularly members of organizations like the Michigan Dental Association, to understand antitrust laws and their implications. The U.S. Justice Department and Federal Trade Commission actively pursue antitrust violations among physicians and dentists. The article outlines key aspects of the Sherman Antitrust Act, emphasizing that joint activities among independent dentists that restrain competition may lead to violations. The concept of joint action and the restraint on competition are explored, with a focus on potential pitfalls, such as price-fixing and group boycotts. Dentists are urged to stay informed to avoid legal consequences.

Dentistry And The Law: Responding To Internet Criticism And Hipaa Considerations, Dan Schulte Jd

The Journal of the Michigan Dental Association

This Dentistry and the Law column addresses the challenge of responding to online criticism as a healthcare professional, particularly dentists. The question involves a patient posting false and damaging information online, leading to concerns about reputation and the desire to set the record straight. The response outlines the limitations imposed by HIPAA on using patient information for such purposes and explores the legal complexities in pursuing recourse. The column advises against responding directly to negative online posts, emphasizing proactive reputation management through online advertising and patient testimonials.

Deepen Electronic Health Record Diffusion Beyond Breadth: Game Changers And Decision Drivers, Xuan Wang, Jun Sun, Ying Wang, Yi Liu

Information Systems Faculty Publications

Cloud computing, financial incentive and patient-centered care are the game changers that deepen EHR diffusion beyond breadth. Based on the innovation diffusion theory (IDT), technology-organization-environment (TOE) framework and alignment literature, this study examines how these changes shape business requirement, service value and society need that drive different phases of EHR diffusion in terms of planning, adoption, usage and upgrade. A longitudinal analysis with the USA National Ambulatory Medical Care Survey (NAMCS) reveals the impacts of different drivers on EHR diffusion. In addition to quantitative results, interview observations corroborate the relationships among game changers, decision drivers and EHR diffusion. The findings …

Genetic Variants In Aldh1l1 And Gldc Influence Serine To Glycine Ratio In Hispanic Children, Sergey A. Krupenko, Shelley A. Cole, Ruixue Hou, Karin Haack, Sandra Laston, Nitesh R. Mehta, Anthony G. Comuzzie, Nancy F. Butte, Venkata Saroja Voruganti

School of Medicine Publications

Background: Glycine is a proteogenic amino acid that is required for numerous metabolic pathways, including purine, creatine, heme and glutathione biosynthesis. Glycine formation from serine, catalyzed by serine hydroxy methyltransferase, is the major source of this amino acid in humans. Our previous studies in a mouse model have shown a crucial role for the10-formyltetrahydrofolate dehydrogenase (ALDH1L1) enzyme in serine to glycine conversion.

Objectives: To determine the genomic influence on serine-glycine ratio in 803 Hispanic children from 319 families of the Viva La Familia cohort.

Methods: We performed a genome-wide association analysis for plasma serine, glycine, and serine-glycine ratio in SOLAR …

Making Privacy Injuries Concrete, Peter Ormerod

Faculty Publications

In recent years, the U.S. Supreme Court has repeatedly said that the doctrine of Article III standing deprives the federal courts of jurisdiction over some lawsuits involving intangible injuries. The lower federal courts are carrying out the Supreme Court’s instructions, and privacy injuries have borne the brunt of the Court’s directive. This Article identifies two incoherencies in the Court’s recent intangible injury decisions and builds on the work of privacy scholars to fashion a solution.

The first incoherency is a line-drawing problem: the Court has never explained why some intangible injuries create an Article III injury in fact while others …

Targeting Delivery Of Bcl-2 Family Protein Inhibitor Has The Potential To Treat Cancer And Fibrosis, Mohammad Nurul Huda

Open Access Theses & Dissertations

Apoptosis is a naturally occurring cell death mechanism to remove the selective cell population. B-cell leukemia/lymphoma-2 (BCL-2) family protein plays a critical role in activating the upstream apoptosis signaling pathway, primarily the intrinsic apoptosis pathway. The BCL-2 family consists of both pro-and anti-apoptotic proteins, which are structurally and functionally similar, containing up to four BCL-2 homologies (BH) motifs (BH1-4). Defecting apoptosis along this signaling pathway can lead to various events, including malignant cell transformation, tumor metastasis, tissue fibrosis, and drug resistance. In fibrosis, the aberrant apoptosis signaling also activates multiple effector proteins and growth factors, such as TGF-β, CTGF, and …

Structural And Biochemical Studies On Disease Associated Proteins: Heat Shock Protein 60 And Hiv Capsid, Alejandro Rodriguez

Open Access Theses & Dissertations

Structural studies on proteins provide valuable knowledge, from information about their fundamental nature, to laying a foundation for rational drug design. Here, we study two proteins, a human mitochondrial chaperonin heat shock protein 60 (Hsp60) and the main structural HIV-1 protein capsid (CA). We focus on the structural nature of both proteins to try to understand their role in disease and elucidate the mechanism of potential drug treatments. Hsp60 is a chaperonin found in human mitochondria that is responsible for assisting client proteins reach their native, functional, state. The mechanism by which it catalyzes protein folding, however, has not been …

Perturbed Hematopoiesis In Individuals With Germline Dnmt3a Overgrowth Tatton-Brown-Rahman Syndrome, Ayala Tovy, Carina Rosas, Amos S Gaikwad, Geraldo Medrano, Linda Zhang, Jaime M Reyes, Yung-Hsin Huang, Tastuhiko Arakawa, Kristen Kurtz, Shannon E Conneely, Anna G Guzman, Rogelio Aguilar, Anne Gao, Chun-Wei Chen, Jean J Kim, Melissa T Carter, Amaia Lasa-Aranzasti, Irene Valenzuela, Lionel Van Maldergem, Lorenzo Brunetti, M John Hicks, Andrea N Marcogliese, Margaret A Goodell, Rachel E Rau

Faculty, Staff and Students Publications

Tatton-Brown-Rahman syndrome (TBRS) is an overgrowth disorder caused by germline heterozygous mutations in the DNA methyltransferase DNMT3A. DNMT3A is a critical regulator of hematopoietic stem cell (HSC) differentiation and somatic DNMT3A mutations are frequent in hematologic malignancies and clonal hematopoiesis. Yet, the impact of constitutive DNMT3A mutation on hematopoiesis in TBRS is undefined. In order to establish how constitutive mutation of DNMT3A impacts blood development in TBRS we gathered clinical data and analyzed blood parameters in 18 individuals with TBRS. We also determined the distribution of major peripheral blood cell lineages by flow cytometric analyses. Our analyses revealed non-anemic macrocytosis, …

Sober Thoughts On Drunken Consent: Intoxication And Consent To Sexual Relations, Samuel Director

Jepson School of Leadership Studies articles, book chapters and other publications

Drunken sex is common. Despite how common drunken sex is, we think
very uncritically about it. In this paper, I want to examine whether drunk individuals
can consent to sex. Specifically, I answer this question: suppose that an individual,
D, who is drunk but can still engage in reasoning and communication, agrees to have
sex with a sober individual, S; is D’s consent to sex with S morally valid? I will argue
that, within a certain range of intoxication, an individual who is drunk can give valid
consent to have sex with an individual who is sober.

Vestibular Rehabilitation For Peripheral Vestibular Hypofunction: An Updated Clinical Practice Guideline From The Academy Of Neurologic Physical Therapy Of The American Physical Therapy Association, Courtney D Hall, Susan J Herdman, Susan L Whitney, Eric R Anson, Wendy J Carender, Carrie W Hoppes, Stephen P Cass, Jennifer B Christy, Helen S Cohen, Terry D Fife, Joseph M Furman, Neil T Shepard, Richard A Clendaniel, J Donald Dishman, Joel A Goebel, Dara Meldrum, Cynthia Ryan, Richard L Wallace, Nakia J Woodward

Faculty, Staff and Students Publications

BACKGROUND: Uncompensated vestibular hypofunction can result in symptoms of dizziness, imbalance, and/or oscillopsia, gaze and gait instability, and impaired navigation and spatial orientation; thus, may negatively impact an individual's quality of life, ability to perform activities of daily living, drive, and work. It is estimated that one-third of adults in the United States have vestibular dysfunction and the incidence increases with age. There is strong evidence supporting vestibular physical therapy for reducing symptoms, improving gaze and postural stability, and improving function in individuals with vestibular hypofunction. The purpose of this revised clinical practice guideline is to improve quality of care …

It Is Not The Time To Relax Yet: Masks Are Still Needed For The Omicron Variant Of Sars-Cov-2, Scott Lowe, Ruijin Xie, Yue Chen, Yifan Shen, Chenyu Sun

Student Publications

No abstract provided.

What Is Meaningful Participation For Physical Therapists In Multidisciplinary Cancer Conferences And Tumor Boards?, Stacy Weber, Athena A. Manzino, Christopher M. Wilson, Nicole D. Booms

Articles

Tumor boards are multidisciplinary team meetings composed of providers from different specialties who collaborate to provide comprehensive cancer care. Although the term “tumor board” may be used commonly in practice, these meetings are often referred to as multidisciplinary cancer conferences (MCCs) within the literature and are referred to as such in this article. At this time, there is no current literature describing the role of physical therapists (PTs) and rehabilitation professionals as part of the MCC or multidisciplinary tumor boards. Yet, PTs are often included as part of this multidisciplinary team in cancer care. This inclusion has not completely shifted …

Centers For Mendelian Genomics: A Decade Of Facilitating Gene Discovery, Samantha M Baxter, Jennifer E Posey, Nicole J Lake, Nara Sobreira, Jessica X Chong, Steven Buyske, Elizabeth E Blue, Lisa H Chadwick, Zeynep H Coban-Akdemir, Kimberly F Doheny, Colleen P Davis, Monkol Lek, Christopher Wellington, Shalini N Jhangiani, Mark Gerstein, Richard A Gibbs, Richard P Lifton, Daniel G Macarthur, Tara C Matise, James R Lupski, David Valle, Michael J Bamshad, Ada Hamosh, Shrikant Mane, Deborah A Nickerson, Heidi L Rehm, Anne O'Donnell-Luria

Faculty, Staff and Student Publications

PURPOSE: Mendelian disease genomic research has undergone a massive transformation over the past decade. With increasing availability of exome and genome sequencing, the role of Mendelian research has expanded beyond data collection, sequencing, and analysis to worldwide data sharing and collaboration.

METHODS: Over the past 10 years, the National Institutes of Health-supported Centers for Mendelian Genomics (CMGs) have played a major role in this research and clinical evolution.

RESULTS: We highlight the cumulative gene discoveries facilitated by the program, biomedical research leveraged by the approach, and the larger impact on the research community. Beyond generating a list of gene-phenotype relationships …

Stem Discovery Lab Application, Sarah Grosvenor

UNH Cooperative Extension

No abstract provided.

Starting A Farm Business: Self Assessment Workbook, Kelly Mcadam

UNH Cooperative Extension

No abstract provided.

New Farmer School: Developing A Values-Based Vision For Your Farm, Kelly Mcadam

UNH Cooperative Extension

No abstract provided.

Hiv-Associated Nephropathy Presenting As The First Manifestation Of Hiv-2 Infection, Kamil Sardarli, Rania Daboul, Sumesh Khanal, Sami Zarouk

Conference Presentation Abstracts

HIV-2 is distinguished from HIV-1 with low virulence, longer asymptomatic period, slower decline in CD4 count, low viral load, and low mortality from AIDS. While the kidney pathology associated with HIV-1 is well established, due to its low prevalence, kidney pathology in HIV-2 is not well documented. We report a case of HIV associated nephropathy (HIVAN) as the first presentation in a patient with HIV-2. A 65 year old man from Ghana presented within a few days of arrival to the United States with nausea, loss of appetite, shortness of breath, and bilateral lower extremity edema. He has a past …

A Lesson Learned From Mounting A Motorcycle, Joseph Friedli, Tyler Drewry, Nobin Kottukapally, Carolyn Landsberg

Conference Presentation Abstracts

A 32-year-old male presented for evaluation of right knee pain.

Insar As A Tool For Monitoring Hydropower Projects: A Review, J. Aswathi, R. B. Binoj Kumar, Thomas Oommen, E. H. Bouali, K. S. Sajinkumar

Michigan Tech Publications, Part 1

This paper provides a review of using Interferometric Synthetic Aperture Radar (InSAR), a microwave remote sensing technique, for deformation monitoring of hydroelectric power projects, a critical infrastructure that requires consistent and reliable monitoring. Almost all major dams around the world were built for the generation of hydropower. InSAR can enhance dam safety by providing timely settlement measurements at high spatial-resolution. This paper provides a holistic view of different InSAR deformation monitoring techniques such as Differential Synthetic Aperture Radar Interferometry (DInSAR), Ground-Based Synthetic Aperture Radar (GBInSAR), Persistent Scatterer Interferometric Synthetic Aperture Radar (PSInSAR), Multi-Temporal Interferometric Synthetic Aperture Radar (MTInSAR), Quasi-Persistent Scatterer …

Hypothermia For Patients Requiring Evacuation Of Subdural Hematoma: A Multicenter Randomized Clinical Trial, Georgene W Hergenroeder, Michael N Diringer, Et Al.

2020-Current year OA Pubs

BACKGROUND: Hypothermia is neuroprotective in some ischemia-reperfusion injuries. Ischemia-reperfusion injury may occur with traumatic subdural hematoma (SDH). This study aimed to determine whether early induction and maintenance of hypothermia in patients with acute SDH would lead to decreased ischemia-reperfusion injury and improve global neurologic outcome.

METHODS: This international, multicenter randomized controlled trial enrolled adult patients with SDH requiring evacuation of hematoma within 6 h of injury. The intervention was controlled temperature management of hypothermia to 35 °C prior to dura opening followed by 33 °C for 48 h compared with normothermia (37 °C). Investigators randomly assigned patients at a 1:1 …

Sucroferric Oxyhydroxide For Hyperphosphatemia: A Review Of Real-World Evidence, Daniel W Coyne, Stuart M Sprague, Marc Vervloet, Rosa Ramos, Kamyar Kalantar-Zadeh

2020-Current year OA Pubs

Hyperphosphatemia is a common complication in dialysis-dependent patients with chronic kidney disease. Most dialysis-dependent patients need oral phosphate binder therapy to control serum phosphorus concentrations. Most phosphate binders have a high daily pill burden, which may reduce treatment adherence and impair phosphorus control. Sucroferric oxyhydroxide is a potent iron-based phosphate binder approved for use in dialysis-dependent patients in 2013. A randomized controlled trial of sucroferric oxyhydroxide demonstrated its efficacy for reduction of serum phosphorus with a lower pill burden than sevelamer carbonate. Clinical trials carefully select patients, monitor adherence, and routinely titrate medications to a protocol-defined goal. Consequently, trials may …

Student Nurses' Career Preferences For Working With People With Dementia: A Longitudinal Cohort Study, M Hebditch, S Daley, W Grosvenor, Et Al

Peninsula Medical School

BACKGROUND: Internationally there are too few suitably skilled registered nurses to meet the demands for dementia care. Research has established low preferences in undergraduate nursing students for working with older people. However, there is limited research on preferences for dementia care. Understanding career preferences is one component of ensuring future workforce capacity. OBJECTIVE: To assess student nurses' preferences during undergraduate training in relation to working with people with dementia. METHODS: Data from a longitudinal survey collected at two UK universities were analysed (n = 488). Measures included career preferences, demographics, participation in a dementia educational intervention, and measures of attitude, …

Reach And Adoption Of A Geriatric Emergency Department Accreditation Program In The United States, Maura Kennedy, Adriane Lesser, Juhi Israni, Shan W Liu, Ilianna Santangelo, Nicole Tidwell, Lauren T Southerland, Christopher R Carpenter, Kevin Biese, Surriya Ahmad, Ula Hwang

2020-Current year OA Pubs

STUDY OBJECTIVE: The objectives of this study were to describe the reach and adoption of Geriatric Emergency Department Accreditation (GEDA) program and care processes instituted at accredited geriatric emergency departments (EDs).

METHODS: We analyzed a cross-section of a cohort of US EDs that received GEDA from May 2018 to March 2021. We obtained data from the American College of Emergency Physicians and publicly available sources. Data included GEDA level, geographic location, urban/rural designation, and care processes instituted. Frequencies and proportions and median and interquartile ranges were used to summarize categorical and continuous data, respectively.

RESULTS: Over the study period, 225 …

‘It’S Not Just Music, It Helps You From Inside’: Mixing Methods To Understand The Impact Of Music On Young People In Contact With The Criminal Justice System, L Caulfield, A Jolly, E Simpson, Y Devi-Mcgleish

School of Health Professions

In response to some of the criticisms of previous research into the arts in criminal justice, this article presents findings from research with a music programme run by a Youth Offending team (YOT). Data were collected on the attendance of 42 participants at YOT appointments – matched against a comparison group – and measures of change over time in musical development, attitudes and behaviour and well-being. Participants who completed the music programme were statistically more likely to attend YOT appointments than a comparison group. There were statistically significant improvements in participants’ self-reported well-being and musical ability over the course of …

Issues Of Context, Capacity And Scale: Essential Conditions And Missing Links For A Sustainable Blue Economy, Holly J. Niner, Noel C. Barut, Tom Baum, Daniela Diz, Daniela Laínez Del Pozo, Stuart Laing, Alana Malinde S.N. Lancaster, Kirsty A. Mcquaid, Tania Mendo, Elisa Morgera, Payal N. Maharaj, Ifesinachi Okafor-Yarwood, Kelly Ortega-Cisneros, Tapiwa V. Warikandwa, Sian Rees

School of Biological and Marine Sciences

The blue economy has roots in the international arena of sustainable development and sets out to unlock opportunities for economy and society whilst protecting and enhancing marine environments. To date there has been no analysis of how this overarching intention for sustainability has influenced the rapid development of blue economy policies at national and regional scales. In this article, we analyse the synergies and conflicts between blue economy policies from a diversity of national and regional policies and the UN Sustainable Development Goals. We show that to maintain critical alignment with targets for sustainability, place-based contextual development of blue economies …

Preparedness Of Recent Medical Graduates To Meet Anticipated Healthcare Needs, T Gale, N Brennan, N Langdon, J Read, N Keates, L Burns, H Khalil, K Mattick

Peninsula Medical School

No abstract provided.

Microplastics In The Atmosphere Of Ahvaz City, Iran, Sajjad Abbasi, Neamatollah Jaafarzadeh, Amir Zahedi, Maryam Ravanbakhsh, Somayeh Abbaszadeh, Andrew Turner

School of Geography, Earth and Environmental Sciences

Airborne particulate matter (PM) with an aerodynamic size cutoff of 10 µm (PM10) has been collected using a high volume air sampler at two locations (urban and residential) in the city of Ahvaz, Iran, for sixteen 24-hour periods over four months (late summer to early winter). Microplastics (MPs) in the PM were isolated after sample digestion and were subsequently characterised by established techniques. All MPs sampled (n = 322) were of a fibrous nature, with polyethylene terephthalate, nylon and polypropylene being the dominant polymers and consistent with textiles and fabrics as the principal source. Despite a distinct seasonality (temperature and …

An International Survey On Nasal Nitric Oxide Measurement Practices For The Diagnosis Of Primary Ciliary Dyskinesia, Nicole Beydon, Thomas Ferkol, Et Al.

2020-Current year OA Pubs

Nasal nitric oxide (nNO) measurements are used in the assessment of patients suspected of having primary ciliary dyskinesia (PCD), but recommendations for performing such measurements have not focused on children and do not include all current practices. To guide the development of a European Respiratory Society-supported technical standard for nNO measurement in children, an international online survey was conducted to better understand current measurement practices among providers involved in PCD diagnostics. 78 professionals responded, representing 65 centres across 18 countries, mainly in Europe and North America. Nearly all centres measured nNO in children and more than half performed measurements before …