Digital Commons Network^™

Troponin Is Unrelated To Outcomes In Heart Failure Patients Discharged From The Emergency Department, Gregory J Fermann, Douglas Char, Et Al

2020-Current year OA Pubs

BACKGROUND: Prior data has demonstrated increased mortality in hospitalized patients with acute heart failure (AHF) and troponin elevation. No data has specifically examined the prognostic significance of troponin elevation in patients with AHF discharged after emergency department (ED) management.

OBJECTIVE: Evaluate the relationship between troponin elevation and outcomes in patients with AHF who are treated and released from the ED.

METHODS: This was a secondary analysis of the Get with the Guidelines to Reduce Disparities in AHF Patients Discharged from the ED (GUIDED-HF) trial, a randomized, controlled trial of ED patients with AHF who were discharged. Patients with elevated conventional …

Joanne Knight Breast Health Cohort At Siteman Cancer Center, Graham A Colditz, Debbie L Bennett, Jennifer Tappenden, Courtney Beers, Nicole Ackermann, Ningying Wu, Jingqin Luo, Sarah Humble, Erin Linnenbringer, Kia Davis, Shu Jiang, Adetunji T Toriola

2020-Current year OA Pubs

PURPOSE: The Joanne Knight Breast Health Cohort was established to link breast cancer risk factors, mammographic breast density, benign breast biopsies and associated tissue markers, and blood markers in a diverse population of women undergoing routine mammographic screening to study risk factors and validate models for breast cancer risk prediction.

METHODS: Women were recruited from November 2008 to April 2012 through the mammography service at the Joanne Knight Breast Health Center at Washington University in St. Louis, Missouri. Baseline questionnaire risk factors, blood, and screening mammograms were collected from 12,153 women. Of these, 1,672 were excluded for prior history of …

Phase 1b Trial Of Anti-Vegf/Pdgfr Vorolanib Combined With Immune Checkpoint Inhibitors In Patients With Advanced Solid Tumors, Nusayba A Bagegni, Haeseong Park, Katlyn Kraft, Maura O-Toole, Feng Gao, Saiama N Waqar, Lee Ratner, Daniel Morgensztern, Siddhartha Devarakonda, Manik Amin, Maria Q Baggstrom, Chris Liang, Giovanni Selvaggi, Andrea Wang-Gillam

2020-Current year OA Pubs

PURPOSE: Vorolanib is a multi-target tyrosine kinase inhibitor with anti-angiogenic properties. This study aimed to evaluate the tolerability, safety and efficacy of vorolanib when added to checkpoint inhibitors (CPIs) in patients with advanced solid tumors.

METHODS: We conducted a phase 1b study of vorolanib (300 or 400 mg orally once daily) plus pembrolizumab or nivolumab using a standard 3 + 3 design to determine the dose-limiting toxicity (DLT), maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D). The endpoints included safety, toxicity and objective response rate, according to Response Evaluation Criteria in Solid Tumors, version 1.1 (RECIST 1.1).

RESULTS: …

Enhancing Discovery Of Genetic Variants For Posttraumatic Stress Disorder Through Integration Of Quantitative Phenotypes And Trauma Exposure Information, Adam X. Maihofer, Andrew C. Heath, Et Al.

2020-Current year OA Pubs

BACKGROUND: Posttraumatic stress disorder (PTSD) is heritable and a potential consequence of exposure to traumatic stress. Evidence suggests that a quantitative approach to PTSD phenotype measurement and incorporation of lifetime trauma exposure (LTE) information could enhance the discovery power of PTSD genome-wide association studies (GWASs).

METHODS: A GWAS on PTSD symptoms was performed in 51 cohorts followed by a fixed-effects meta-analysis (N = 182,199 European ancestry participants). A GWAS of LTE burden was performed in the UK Biobank cohort (N = 132,988). Genetic correlations were evaluated with linkage disequilibrium score regression. Multivariate analysis was performed using Multi-Trait Analysis of GWAS. …

Narratives Bridge The Divide Between Distant Events In Episodic Memory, Brendan I Cohn-Sheehy, Angelique I Delarazan, Jordan E Crivelli-Decker, Zachariah M Reagh, Nidhi S Mundada, Andrew P Yonelinas, Jeffrey M Zacks, Charan Ranganath

2020-Current year OA Pubs

Many studies suggest that information about past experience, or episodic memory, is divided into discrete units called "events." Yet we can often remember experiences that span multiple events. Events that occur in close succession might simply be linked because of their proximity to one another, but we can also build links between events that occur farther apart in time. Intuitively, some kind of organizing principle should enable temporally distant events to become bridged in memory. We tested the hypothesis that episodic memory exhibits a narrative-level organization, enabling temporally distant events to be better remembered if they form a coherent narrative. …

Aerial Radiation Detection Identification And Measurement System Detector Material Comparison Study, Benjamin C. Troxell, Kacey D. Mcgee, Christina L. Dugan

Faculty Publications

The 20th Chemical Biological Radiological Nuclear and Explosives Command (CBRNE) currently utilizes an airborne sodium iodide gamma and beta detection system to map radiation fields over large areas of interest. The 20th CBRNE explored emergent detector technologies utilizing two detection materials; thallium-activated cesium iodide and high purity germanium (HPGe). These detectors were simulated at various altitudes and compared to background measurements. The sodium iodide detector failed to provide isotopic discrimination at distance. The thallium-activated cesium iodide CsI(Tl) detector provided sufficient absolute efficiency and energy resolution to identify isotopics at distance. The HPGe detector provided the best energy resolution. However, current …

Ud In The News March 25-April 1, University Of Dayton

News Releases

The Conversation, America magazine, CBS News, The Washington Post, Popular Science, Catholic News Service and a radio station in South Korea highlight the list of media outlets seeking UD faculty expertise. UD President Eric F. Spina wrote in the Dayton Daily News about President Emeritus Bro. Ray Fitz, S.M., and his life's work as a catalyst for social justice.

Reconceiving Coercion-Based Criminal Defenses, Stephen R. Galoob, Erin L. Sheley

Faculty Scholarship

Coercing someone is sometimes wrong and sometimes a crime. People subject to coercion are sometimes eligible for criminal defenses, such as duress. How, exactly, does coercion operate in such contexts? Among legal scholars, the predominant understanding of coercion is the “wrongful pressure” model, which states that coercion exists when the coercer wrongfully threatens the target and, as a result of this threat, the target is pressured to act in accordance with the coercer’s threat. Some tokens of coercion do not fit neatly within existing legal categories or the wrongful pressure model of coercion. For example, coercive control is a psychological …

College Of Natural Sciences Newsletter, March & April 2022, College Of Natural Sciences

College of Natural Sciences Newsletters and Reports

Volume 3, Issue 3

Page 1 Dean's Message
Page 2-3 Awards and Recognition
Page 4 2022 URSCAD - CNS Snaps
Page 5 Geography Convention Recap
Page 6 Attention Students!
Page 7-8 Media Coverage of CNS
Page 9 Spring Break Outreach, Adopt the Pantry,
Page 10 Discovery on Tap Event
Page 11 CNS Students Visit State Capital
Page 12 Celebrating 50 Years of Sally
Page 13 Open PRAIRIE Data
Page 14 Grants Awarded and Bio-Micro Day of Scholars
Page 15 -17 2022 Geography Convention Snaps
Page 18 Sally Krueger's 50th Work Anniversary

Freedom Within Convention: A Cooperative Analysis Of The Zhuangzi And A Thousand Plateaus, Giacomo Coppola

Student Publications

The Zhuangzi, a foundational text in Classical Chinese philosophy, presents a notion of ideal humanity that involves a seemingly paradoxical relationship between a liberated existence and the barriers that restrict it. To achieve ideal humanity, one must confront the boundaries and attachments that have coalesced into a web of socio-physical conventions and developed dominion over human thought and action. This paper aims at shedding some light on this tension by offering a comparative analysis of the Zhuangzi and A Thousand Plateaus by Gilles Deleuze and Felix Guattari in terms of their conceptions of ideal humanity. While an abundance of time …

Antitrust, Attention, And The Mental Health Crisis, Gregory Day

Minnesota Law Review Vols. 106:2 onward (2021-present)

No abstract provided.

Designer Minor: Creating A Better Legal Regime For Pediatric Cosmetic Procedures, Hannah Oliason

Minnesota Law Review Vols. 106:2 onward (2021-present)

No abstract provided.

A Computer Vision-Based Method For Bolt Loosening Detection, Savannah Burdette

Honors Theses

Routine bolt-loosening inspection plays an essential role in managing and preventing the degradation of our nation’s highway bridges over time. Neglecting to perform these inspections could result in public safety concerns. The study of this thesis develops a cost-effective method of bolt-loosening detection based on computer vision. To this end, two input images of the bolted connections are collected at two different inspection times. The feature points are then identified from the input images, based on which a geometric transformation matrix is applied to correct any perspective differences between the two images. Next, we select the image patches of the …

Contraceptive Knowledge Of Female College Students, Lina Perugini

Honors Theses

Background: Over 37% of teens (aged 15-19) and 62% of young adult (20-29) women use some method of contraception (Daniels, 2019). Women in college demonstrate inconsistent use and lack of knowledge about reproduction, menstruation, and contraception (Sutton, 2017). This study aimed to assess collegiate women’s knowledge of contraceptive and tested two hypotheses: (1) women in college will demonstrate a lack of knowledge about contraception; (2) those who use hormonal birth control will demonstrate significantly higher levels of contraceptive knowledge when compared to non-users. Method: 128 female college students completed an anonymous online survey that included demographic information, history of contraceptive …

Examining The Impacts Of Flooding On Public Health, Lauren Gibson

Honors Theses

Over the past 10 years, South Carolina has experienced over five major weather events that have led to extreme flooding along the coast. These types of repeated major events have the potential to significantly impact people’s lives and livelihoods. When looking at the issue from a public health perspective, it is known that natural disasters such as flooding can negatively affect community health. However, little research has been done to analyze the impacts on individual health from flooding. This issue inspired a more in-depth research analysis to examine those health impacts from local Horry County residents. This research aims to …

Defining The Leading Edge Of The Marine – Non-Marine Transition In The Pee Dee Basin: Influences, And Dynamic Parameters Of A Highly Dynamic System, Nicole Mchugh

Honors Theses

Among estuaries, there is a large block of co-dependent and independent variables shaping habitat and environmental conditions within a critical area. Historical data proxies and indexes from seven different stations were assessed to consider temporal and spatial variability of the marine and non-marine transition along the South Carolina Pee Dee River Basin. Historical datasets from the upper reaches of Winyah Bay and lower section of the Pee Dee River basin were compiled along with shorter termed deployments of a new instrument station installed near Georgetown, SC. This area is representative of the marine-non-marine transition in drowned river mouth estuaries. Water …

Lost In The Cloud: The Experiences Of College Students With Visual Impairments In An Online Environment, Gwen A. Bostic

Dissertations

Online courses have become a necessity in education. Still, the online learning format, course design, and course management systems are not always conducive for learners with visual impairments. “A key concern is that faculty and individuals accountable for supporting and implementing e-learning within postsecondary institutions, in a rush to integrate technology into teaching, fail to think about the accessibility needs of students with various disabilities” (Fichten, 2009, p. 242).

This qualitative study aimed to describe and interpret the lived experiences of college students who are blind or visually impaired in an online environment. This study involved ten blind or low-vision …

Mental Health Functioning, History Of Trauma, And Parent Stress In Maltreating Parents, Dionne G. Pinto-Guerra

McNair Scholars Manuscripts

Objective: Child maltreatment is common and can lead to a host of negative outcomes, so understanding the factors that influence risk for maltreatment is warranted. The present study examined the role of parent history of trauma in shaping parent stress in a sample of maltreating parents. Adverse Childhood Experiences (ACES) provide one way to quantify cumulative childhood trauma, and the experience of ACEs has been found to negatively impact mental and physical adult health outcomes. These findings are consistent with non-ACEs-related trauma research, which also shows that history of trauma leads to negative long-term outcomes, which may influence later parenting. …

National Athletes' Perceived Image Of The Government In The Development Of Sports In Malaysia, Danial Bin Azizan Durisic

Theses and Dissertations

Malaysian national sports depend on the support of the government to further improve its quality and continue to grow. The declining quality of Malaysian sports prompted this study, which seeks to explore the perceptions of the Malaysian government’s sport development efforts through the lens of the national athletes and provide recommendations that could lead to strengthened sports development and improved quality of sports in Malaysia. This research intends to compare the results obtained from current and former national athletes and compare it with the Sport Policy Factors Leading to International Sporting Success or SPLISS Model (Bosscher et al., 2006), which …

Exploration Of The Role Of Neighborhood Residential Segregation By Race And Ethnicity In Obesity Risk Among School-Aged, Melissa L. Fair

Theses and Dissertations

Youth obesity prevalence remains high, despite decades of intervention. Grounded in the social ecological model, neighborhoods and schools are important settings in addressing the complex systems that influence obesity. Contributing to disparities, by race/ethnicity, Black and Hispanic youth are more likely to live in segregated neighborhoods and attend segregated schools, which are also more likely to have high rates of poverty and are less likely to have high quality nutrition and built environments. Leveraging data from local school district (district and state department of education) and national datasets (ACS, Childhood Opportunity Index 2.0), this study examined the associations between school …

“Forward—Upward—On!”: Black Student And Educator Experiences In The Early Years Of School District Five Of Lexington And Richland Counties, Charles A. Holden

Theses and Dissertations

This research utilized historical analysis, narrative inquiry, and oral history to document and analyze Black educational experiences in the Chapin, Dutch Fork, and Irmo communities during segregation and desegregation. Archival materials from the local school district offered insight into district leaders’ attitudes towards Richlex, the only public school available to the area’s Black students between 1953 and 1966, as well as the conditions that district leaders created for Black students and educators. Former students’ stories were centered in both the examination of what the local Black communities accomplished in spite of the unequal conditions of the segregated era and in …

Alba And Unasur: Back To The Future?, Porrata-Doria, Jr., Rafael A.

Santa Clara Journal of International Law

This essay discusses efforts at creating a unified Latin American region through the lens of different integration attempts. Part I briefly examines MERCOSUR and the Andean Group and how these two efforts failed to achieve promises made under the free trade model that grew under the Washington Consensus. Structural problems and changing political tides left these two groups unsuccessful, and ultimately the election of populist leftwing presidents in Argentina, Brazil, and Venezuela ushered in a new model of integration intended to increase the economic development of Latin America in an equitable fashion. Despite their different ideologies and missions, both Alianza …

Introduction To Fcr Special Issue On Covid-19 Pandemic, Amy G. Applegate, Alexandra Crampton, Barbara Glesner Fines

Social and Cultural Sciences Faculty Research and Publications

No abstract provided.

2022 Awardees, Office Of Sponsored Projects, Academic Research And Compliance (Sparc)

Showcase Awards

Every year, St. Mary's honors their students and faculty at the showcase with awards to recognize their hard work and leadership in research on campus. These are the award winners for 2022.

Infection With The Hepatitis C Virus Causes Viral Genotype-Specific Differences In Cholesterol Metabolism And Hepatic Steatosis, David A. Sheridan, Isaac Thom Shawa, E. Louise Thomas, Daniel J. Felmlee, Simon H. Bridge, Dermot Neely, Jeremy F. Cobbold, Elaine Holmes, Margaret F. Bassendine, Simon D. Taylor-Robinson

Peninsula Medical School

Lipids play essential roles in the hepatitis C virus (HCV) life cycle and patients with chronic HCV infection display disordered lipid metabolism which resolves following successful anti-viral therapy. It has been proposed that HCV genotype 3 (HCV-G3) infection is an independent risk factor for hepatocellular carcinoma and evidence suggests lipogenic proteins are involved in hepatocarcinogenesis. We aimed to characterise variation in host lipid metabolism between participants chronically infected with HCV genotype 1 (HCV-G1) and HCV-G3 to identify likely genotype-specific differences in lipid metabolism. We combined several lipidomic approaches: analysis was performed between participants infected with HCV-G1 and HCV-G3, both in …

Assessing The Effectiveness Of An Egg Intervention In The Nutritional And Food Security Status Of Infants And Toddlers From Rural Honduras, Aishat Adewoye, Mario Keko, Luke Roberson, Dziyana Nazaruk, Gisela Ramos, Laura Manship, Haresh Rochani, Asli Aslan, Ana M. Palacios

Biostatistics, Epidemiology & Environmental Health Sciences: Faculty Publications

No abstract provided.

Groundwater Policy And Planning, Jenny Grönwall, Marianne Kjellén, Gabriel Eckstein, Kerstin Danert, Lesha Witmer, Rebecca Welling, Viviana Re, Katharina Davis, Lulu Zhang

Faculty Scholarship

Groundwater policy defines objectives, ambitions and priorities for managing groundwater resources, for the benefit of society. Planning translates policy into programmes of action. Both are often part of a wider water resource policy and planning framework, but the specific challenges pertaining to groundwater have traditionally received less attention than surface water.

The terms ‘policy,’ ‘strategy’ and ‘plans’ are used interchangeably in many countries and contexts.

Legal And Other Institutional Aspects Of Groundwater Governance, Jenny Grönwall, Marianne Kjellén, Alice Aureli, Stefano Burchi, Mohamed Bazza, Raya Marina Stephan, Gabriel Eckstein, Lesha Witmer, Margreet Zwarteveen, Aurélien Dumont, Danielle Gaillar-Picher, Rio Hada, Rebecca Welling, Maki Tsujimura

Faculty Scholarship

This chapter defines the linked concepts of groundwater governance and groundwater management, explaining how they differ from each other. Then, it describes the prevailing legal instruments for, and the institutional aspects of, groundwater management and governance.

Evaluating Legal Needs, Luz E. Herrera, Amber Baylor, Nandita Chaudhuri, Felipe Hinojosa

Faculty Scholarship

This article is the first to explore legal needs in the Rio Grande Valley of Texas––a region that is predominantly Latinx and has both rural and urban characteristics. There are few legal needs assessments of majority Latinx communities, and none that examine needs in areas that are also U.S. border communities. Access to justice studies often overlook this area of the U.S. and this segment of the population despite their unique qualities. Latinos are projected to constitute the largest ethnic group in the country by 2060, making it imperative that we study access to justice-related assets, needs, opportunities, and barriers …

From Pandemic To Pedagogy: Teaching The Technology Of Lawyering In Law Clinics, Sarah R. Boonin, Luz E. Herrera

Faculty Scholarship

The COVID-19 pandemic has transformed the nation’s approach to work and learning. Law schools, law firms, courts, and administrative agencies abruptly closed their offices and quickly reimagined how to perform their daily functions remotely. Many of these institutions have plans to maintain aspects of remote operations and services post-pandemic. With this in mind, the authors of this Article conducted a survey of law school clinical faculty during the winter of 2021 to better understand how clinicians pivoted their instruction and practice using technology during the pandemic. The authors use the survey results to show how the COVID-19 experience positions clinical …