Digital Commons Network^™

Suppressing Fatty Acid Synthase By Type I Interferon And Chemical Inhibitors As A Broad Spectrum Anti-Viral Strategy Against Sars-Cov-2, Saba R. Aliyari, Xiaochao Wei, Clay F. Semenkovich, Et Al.

2020-Current year OA Pubs

SARS-CoV-2 is an emerging viral pathogen and a major global public health challenge since December of 2019, with limited effective treatments throughout the pandemic. As part of the innate immune response to viral infection, type I interferons (IFN-I) trigger a signaling cascade that culminates in the activation of hundreds of genes, known as interferon stimulated genes (ISGs), that collectively foster an antiviral state. We report here the identification of a group of type I interferon suppressed genes, including fatty acid synthase (FASN), which are involved in lipid metabolism. Overexpression of FASN or the addition of its downstream product, palmitate, increased …

Reach And Adoption Of A Geriatric Emergency Department Accreditation Program In The United States, Maura Kennedy, Adriane Lesser, Juhi Israni, Shan W Liu, Ilianna Santangelo, Nicole Tidwell, Lauren T Southerland, Christopher R Carpenter, Kevin Biese, Surriya Ahmad, Ula Hwang

2020-Current year OA Pubs

STUDY OBJECTIVE: The objectives of this study were to describe the reach and adoption of Geriatric Emergency Department Accreditation (GEDA) program and care processes instituted at accredited geriatric emergency departments (EDs).

METHODS: We analyzed a cross-section of a cohort of US EDs that received GEDA from May 2018 to March 2021. We obtained data from the American College of Emergency Physicians and publicly available sources. Data included GEDA level, geographic location, urban/rural designation, and care processes instituted. Frequencies and proportions and median and interquartile ranges were used to summarize categorical and continuous data, respectively.

RESULTS: Over the study period, 225 …

Digital Interventions To Address Mental Health Needs In Colleges: Perspectives Of Student Stakeholders, Naira Topooco, Lauren A Fowler, Ellen E Fitzsimmons-Craft, Bianca Depietro, Melissa M Vázquez, Marie-Laure Firebaugh, Peter Ceglarek, Grace Monterubio, Michelle G Newman, Daniel Eisenberg, Denise E Wilfley, C Barr Taylor

2020-Current year OA Pubs

OBJECTIVE: The need for clinical services in U.S. colleges exceeds the supply. Digital Mental health Interventions (DMHIs) are a potential solution, but successful implementation depends on stakeholder acceptance. This study investigated the relevance of DMHIs from students' perspectives.

METHODS: In 2020-2021, an online cross-sectional survey using mixed methods was conducted with 479 students at 23 colleges and universities. Respondents reported views and use of standard mental health services and DMHIs and rated the priority of various DMHIs to be offered through campus services. Qualitative data included open-ended responses.

FINDINGS: Among respondents, 91% reported having experienced mental health problems, of which …

Treasures From Rowan University Archives And Special Collections, Sara A. Borden

Library Workshops

Learning objectives:

• Participants will learn what primary sources are in a university archives and special collections
• Participants will examine and learn details from historic Rowan University artifacts such as: maps; incunabula and rare books; one-of-a-kind manuscripts detailing southern New Jersey history; and other incredible treasures from the region, the nation, and the world held in the collections
• Participants will understand that archives contain materials that are not only useful for work in humanities and social sciences but archives hold documents and objects of interest to those in STEM studies as well as other fields

Description:

This virtual workshop will clear …

Dipl 4193 Na Eastern European And Post-Soviet Politics, Margarita M. Balmaceda Ph.D.

Diplomacy Syllabi

This course provides a systematic introduction to the main issues in Soviet, post-Soviet and post Soviet-Bloc politics. Some of the topics to be considered are the following: (1) the legacy of Soviet nationality policies and the Soviet planned economy system on the creation and development of new political systems in the former Soviet republics; (2) the political and economic diversity which emerged within the ’Soviet Bloc” starting in the 1950’s, and its effects on the development of new political systems after the fall of Communism: (3) the causes and consequences of ethnic conflicts in some of the countries of the …

Dipl 3370 Wb Gender, Race And Culture In International Relations, Fredline M’Cormack-Hale Ph.D.

Diplomacy Syllabi

That gender should have a central place in international relations is finally beginning to take hold in the discipline. Most, if not all. introductory IR classes spend some time looking at how a study of states and the political and economic power they wield is incomplete without a consideration of how notions of femininity and masculinity also shape international relations. However, while IR scholars share concerns around male dominance in IR, feminism is not a monolithic concept and there is a diversity of both feminist approaches as well as topics studied. Moreover, intersectionality tells us that it is important to …

Dipl 2120 International Conflict And Security, R. Joseph Huddleston Ph.D.

Diplomacy Syllabi

This course serves as a general introduction to the study of international security, a field primarily concerned with the threat and uses of force by state and non-state actors for political ends. Topics examined include the origins of major power wars, regional conflicts, civil wars, and international intervention, as well as terrorism, cyber, and information warfare.

By the end of the semester, students should have acquired knowledge and understanding of key concepts, theories, and debates involved in the study of contemporary international security. Students should also have developed the skills to: analyze complex international systems; find and synthesize empirical information; …

Dipl 2110 Aa/Ab Comparative Foreign Policy, Ann Marie Murphy Ph.D.

Diplomacy Syllabi

This course is an introduction to theories of foreign policy analysis and a survey of the foreign policies of major states. The first part of the course examines alternative theoretical approaches to the study of foreign policy. These conceptual models are then applied to a series of seminal events such as the Cuban Missile Crisis. The second part of the course examines the foreign policy trajectories of a number of important states and explores critical foreign policy dilemmas through two in-class simulations.

Dipl 6170 Wb Advanced Topics In Economic Development, Omer Gokcekus Ph.D.

Diplomacy Syllabi

The main premise of graduate level work Is change. Change requires openness to new ideas. It also requires willingness to abandon old ones. In order to be successful in this course, you should be willing to unlearn and rethink many of the perceptions you might have about economic development: You already know a great deal, taught by politicians, media, roommates, friends, and relatives. Most of these are either incomplete or simply wrong!

Accordingly, to better understand different aspects of economic development, we provide in depth analysis of current aspects of economic development. To do so, instead of picking the issues …

Dipl 6350 Religion, Race, And International Relations, Brian K. Muzás Ph.D.

Diplomacy Syllabi

This course offers an overview of the role of religion and race in international relations. Students explore the causes, nature, and consequences of key issues related to the interplay of religion and race in history at the practical and theoretical levels. By understanding what scholars have learned and connecting these lessons to current events, students will acquire tools to approach contemporary and future issues.

Because of the nature of religion, some guiding questions naturally arise. These include questions like: What is the best way to live? What is the relationship between religion and society? Is religion a strictly private matter? …

Dipl 6311 Na/Nb Master's Research Project, Assefaw Bariagaber Ph.D.

Diplomacy Syllabi

The primary objective of this course is to produce a well-researched, quality paper by applying the principles of and approaches in empirical scientific research (which you covered in DIPL 6310 and for which you have received a course grade of "C” or above) to actual research endeavors. That is, the primary objective is knowledge production on relevant topics in international relations. The secondary objective is critical consumption of existing knowledge on relevant topics in international relations. The latter pertains to understanding and critically analyzing studies conducted by other scholars, as it would be virtually impossible to write a quality paper …

Dipl 6310 Research Methods For Policy Analysis, Martin S. Edwards Ph.D.

Diplomacy Syllabi

This class is intended to accomplish two goals. First, this is a class for you to develop tools to pose questions and answer them in a social scientific fashion. Second, as this class is an essential prerequisite to DIPL 6311, you will finish this class having developed a template for that project.

To accomplish this first goal, we will spend the bulk of class time on understanding both qualitative and quantitative research. The second goal is one of application, as you will use insights picked up throughout the class to produce a research design of your own for use in …

Dipl 6250 Conflict And Conflict Resolution In Plural Societies, Aaron Hale Ph.D.

Diplomacy Syllabi

This course explores conflicts and conflict resolution in plural and culturally diverse societies. Cultural variety and differences can be sources of conflict as well as tools for resolving conflicts. The goal of the course is to introduce students to the importance of understanding cultural diversity for the analysis of social conflict and to learn constructive ways of dealing with adversity that may occur through intercultural encounters. We will focus on both conflict analysis as well as conflict resolution practice through the lens of various cultures. Cases studies will be used to analyze and apply theoretical and practical frameworks pertaining to …

Dipl 6201 United Nations Security Council Issues, Purnaka L. De Silva Ph.D.

Diplomacy Syllabi

The focus and aim of this Course DIPL 6201: United Nations Security Council Issues is to examine United Nations Security Council issues at this critical juncture in global affairs, amidst the backdrop of a rise in undemocratic and illiberal politics in several countries. The United Nations is the world’s premier multilateral organization whose voting membership is made up of sovereign nation-states. And therefore, its success or failure is solely dependent upon the performance or nonoptimal performance of its member states in exercising their political will for the greater good. And it is within the prism of political interactions between the …

Nonlinear Association Of Nurse Staffing And Readmissions Uncovered In Machine Learning Analysis, Olga Yakusheva, James Bang, Ronda G. Hughes, Kathleen L. Bobay, Linda L. Costa, Marianne E. Weiss

College of Nursing Faculty Research and Publications

Objective: Several studies of nurse staffing and patient outcomes found a curvilinear or U-shaped relationship, with benefits from additional nurse staffing diminishing or reversing at high staffing levels. This study examined potential diminishing returns to nurse staffing and the existence of a "tipping point" or the level of staffing after which higher nurse staffing no longer improves and may worsen readmissions.

Data Sources/Study Setting: The Readiness Evaluation And Discharge Interventions (READI) study database of over 130,000 adult (18+) inpatient discharges from 62 medical, surgical, and medical-surgical (noncritical care) units from 31 United States (US) hospitals during October 2014-March 2017.

Study …

Evaluating Climatic Influences On The Technical Performance Of Built Infrastructure Assets, Sarah L. Brown, Steven J. Schuldt, Michael N. Grussing, Michael A. Johnson, Justin D. Delorit

Faculty Publications

Asset performance evaluations serve as a benchmark that can be used to make asset manufacturer selection decisions, i.e., choosing the brand of manufacturer that provides the highest performance among all brand competitors. Understanding the environmental conditions to which assets are subjected provides facility managers another data point to understand asset performance. This research builds upon a previously published performance-based manufacturer selection metric by investigating the linkage between asset performance and exposure to local climate, using chiller and air handler data from 20 United States Air Force installations. The link between environmental factors such as Heating Degree Days (HDD); Cooling Degree …

Biomechanical And Psychological Predictors Of Failure In The Air Force Physical Fitness Test, Jeffrey Turner, Brent T. Langhals, Torrey J. Wagner

Faculty Publications

Physical fitness is a pillar of U.S. Air Force (USAF) readiness and ensures that Airmen can fulfill their assigned mission and be fit to deploy in any environment. The USAF assesses the fitness of service members on a periodic basis, and discharge can result from failed assessments. In this study, a 21-feature dataset was analyzed related to 223 active-duty Airmen who participated in a comprehensive mental and social health survey, body composition assessment, and physical performance battery. Graphical analysis revealed pass/fail trends related to body composition and obesity. Logistic regression and limited-capacity neural network algorithms were then applied to predict …

Inside The Black Box Of Prosecutor Discretion, Shima Baradaran Baughman, Megan S. Wright, Christopher T. Robertson

Faculty Scholarship

In their charging and bargaining decisions, prosecutors have unparalleled and nearly-unchecked discretion that leads to incarceration or freedom for millions of Americans each year. More than courts, legislators, or any other justice system player, in the aggregate prosecutors’ choices are the key drivers of outcomes, whether the rates of mass incarceration or the degree of racial disparities in justice. To date, there is precious little empirical research on how prosecutors exercise their breathtaking discretion. We do not know whether they consistently charge like cases alike or whether crime is in the eye of the beholder. We do not know what …

No Hiding From Justice: Universal Jurisdiction In Domestic Courts, Heidi R. Gilchrist

Faculty Scholarship

No abstract provided.

Spatial Sequestration Of Misfolded Proteins In Neurodegenerative Diseases, Sarah Rolli, Emily M. Sontag

Biological Sciences Faculty Research and Publications

Properly folded, functional proteins are essential for cell health. Cells sustain protein homeostasis, or proteostasis, via protein quality control (PQC) mechanisms. It is currently hypothesized that a breakdown in proteostasis during ageing leads to the accumulation of protein aggregates in the cell and disease. Sequestration of misfolded proteins into PQC compartments represents one branch of the PQC network. In neurodegenerative diseases, certain proteins form abnormal protein deposits. Which PQC compartments house misfolded proteins associated with neurodegenerative diseases is still being investigated. It remains unclear if sequestration of these misfolded proteins is toxic or protective to the cell. Here, we review …

Depression Interventions For Individuals With Coronary Artery Disease - Cost-Effectiveness Calculations From An Irish Perspective, Samira Barbara Jabakhanji, Jan Sorensen, Robert M Carney, Chris Dickens, Martin Dempster, Jonathan Gallagher, Isabela Caramlau, Frank Doyle

2020-Current year OA Pubs

BACKGROUND: A substantial proportion of individuals with coronary artery disease experience moderate or severe acute depression that requires treatment. We assessed the cost-effectiveness of four interventions for depression in individuals with coronary artery disease.

METHODS: We assessed effectiveness of pharmacotherapy, psychotherapy, collaborative care and exercise as remission rate after 8 and 26 weeks using estimates from a recent network meta-analysis. The cost assessment included standard doses of antidepressants, contact frequency, and staff time per contact. Unit costs were calculated as health services' purchase price for pharmaceuticals and mid-point staff salaries obtained from the Irish Health Service Executive and validated by …

Implementation And Early Experience Of A Pediatric Electrophysiology Telehealth Program, Jonathan Schweber, Lisa Roelle, Juliana Ocasio, Aarti S Dalal, Nathan Miller, George F Van Hare, Jennifer N Avari Silva

2020-Current year OA Pubs

BACKGROUND: Telehealth (TH) visits have been growing with exponential increased utilization during the COVID-19 pandemic. The aim of this manuscript is to describe the implementation and early experience of a pediatric electrophysiology (EP) TH program implemented during the pandemic, assessing patient satisfaction, patient equity and inclusion (measured by geographical outreach), and sustainability.

METHODS: A retrospective chart review study was performed and data were collected from the medical record, including demographic, testing, and billing data from scheduled TH encounters between March and August 2020 of a single pediatric EP group in the Midwest. Patients were called to complete satisfaction surveys.

RESULTS: …

An International Survey On Nasal Nitric Oxide Measurement Practices For The Diagnosis Of Primary Ciliary Dyskinesia, Nicole Beydon, Thomas Ferkol, Et Al.

2020-Current year OA Pubs

Nasal nitric oxide (nNO) measurements are used in the assessment of patients suspected of having primary ciliary dyskinesia (PCD), but recommendations for performing such measurements have not focused on children and do not include all current practices. To guide the development of a European Respiratory Society-supported technical standard for nNO measurement in children, an international online survey was conducted to better understand current measurement practices among providers involved in PCD diagnostics. 78 professionals responded, representing 65 centres across 18 countries, mainly in Europe and North America. Nearly all centres measured nNO in children and more than half performed measurements before …

Candidate Genes Modulating Reproductive Timing In Elite Us Soybean Lines Identified In Soybean Alleles Of Arabidopsis Flowering Orthologs With Divergent Latitude Distribution, Nicholas Dietz, Yen On Chan, Andrew Scaboo, George Graef, David Hyten, Mary Happ, Brian Diers, Aaron Lorenz, Dechun Wang, Trupti Joshi, Kristin Bilyeu

Biomedical Sciences

Adaptation of soybean cultivars to the photoperiod in which they are grown is critical for optimizing plant yield. However, despite its importance, only the major loci conferring variation in flowering time and maturity of US soybean have been isolated. By contrast, over 200 genes contributing to floral induction in the model organism Arabidopsis thaliana have been described. In this work, putative alleles of a library of soybean orthologs of these Arabidopsis flowering genes were tested for their latitudinal distribution among elite US soybean lines developed in the United States. Furthermore, variants comprising the alleles of genes with significant differences in …

Hypothermia For Patients Requiring Evacuation Of Subdural Hematoma: A Multicenter Randomized Clinical Trial, Georgene W Hergenroeder, Michael N Diringer, Et Al.

2020-Current year OA Pubs

BACKGROUND: Hypothermia is neuroprotective in some ischemia-reperfusion injuries. Ischemia-reperfusion injury may occur with traumatic subdural hematoma (SDH). This study aimed to determine whether early induction and maintenance of hypothermia in patients with acute SDH would lead to decreased ischemia-reperfusion injury and improve global neurologic outcome.

METHODS: This international, multicenter randomized controlled trial enrolled adult patients with SDH requiring evacuation of hematoma within 6 h of injury. The intervention was controlled temperature management of hypothermia to 35 °C prior to dura opening followed by 33 °C for 48 h compared with normothermia (37 °C). Investigators randomly assigned patients at a 1:1 …

Efficacy And Safety Outcomes With Diroximel Fumarate After Switching From Prior Therapies Or Continuing On Drf: Results From The Phase 3 Evolve-Ms-1 Study, Sibyl Wray, Robert T Naismith, Et Al.

2020-Current year OA Pubs

INTRODUCTION: Diroximel fumarate (DRF) is an oral fumarate for relapsing multiple sclerosis (MS) with the same active metabolite as dimethyl fumarate (DMF). DRF has a safety/efficacy profile similar to DMF but with improved gastrointestinal (GI) tolerability and low (< 1%) treatment discontinuation due to GI adverse events (AEs). Efficacy and safety outcomes in patients who switched to DRF from other disease-modifying therapies (DMTs) have not been evaluated.

METHODS: EVOLVE-MS-1 is an ongoing, 2-year, open-label, phase 3 study of DRF in adults with relapsing-remitting MS. Patients either entered as newly enrolled to DRF trials, or from the 5-week, randomized, head-to-head, phase 3 EVOLVE-MS-2 study of DRF and DMF. This analysis evaluated safety and GI tolerability in patients continuing on DRF (DRF-rollover) or switching from DMF (DMF-rollover) following EVOLVE-MS-2. Safety …

First-In-Human, Open-Label, Phase 1/2 Study Of The Monoclonal Antibody Programmed Cell Death Protein-1 (Pd-1) Inhibitor Cetrelimab (Jnj-63723283) In Patients With Advanced Cancers, Enriqueta Felip, Daniel Morgensztern, Et Al.

2020-Current year OA Pubs

PURPOSE: To assess the safety, pharmacokinetics, pharmacodynamics, and preliminary efficacy of cetrelimab (JNJ-63723283), a monoclonal antibody programmed cell death protein-1 (PD-1) inhibitor, in patients with advanced/refractory solid tumors in the phase 1/2 LUC1001 study.

METHODS: In phase 1, patients with advanced solid tumors received intravenous cetrelimab 80, 240, 460, or 800 mg every 2 weeks (Q2W) or 480 mg Q4W. In phase 2, patients with melanoma, non-small-cell lung cancer (NSCLC), and microsatellite instability-high (MSI-H)/DNA mismatch repair-deficient colorectal cancer (CRC) received cetrelimab 240 mg Q2W. Response was assessed Q8W until Week 24 and Q12W thereafter.

RESULTS: In phase 1, 58 patients …

A Study Examining The Usefulness Of A New Measure Of Research Engagement, Deborah J Bowen, Nicole Ackermann, Vetta Saunders Thompson, Andrea Nederveld, Melody Goodman

2020-Current year OA Pubs

INTRODUCTION: Engagement of relevant stakeholders' ideas, opinions, and concerns is critical to the success of modern research projects. We have developed a tool to measure stakeholder engagement, called the Research Engagement Survey Tool (REST). The purpose of this paper is to present the implementation and uptake of the stakeholder engagement measure REST among research teams, including the assessment of barriers and facilitating factors for use of the new research engagement measure in practice.

METHODS: In this implementation study, project team members participated in baseline and follow-up web-based surveys. Web-based interviews were conducted with a subset of project teams that implemented …

Deglutarylation Of Glutaryl-Coa Dehydrogenase By Deacylating Enzyme Sirt5 Promotes Lysine Oxidation In Mice, Dhaval P Bhatt, C Allie Mills, Kristin A Anderson, Bárbara J Henriques, Tânia G Lucas, Sara Francisco, Juan Liu, Olga R Ilkayeva, Alexander E Adams, Shreyas R Kulkarni, Donald S Backos, Michael B Major, Paul A Grimsrud, Cláudio M Gomes, Matthew D Hirschey

2020-Current year OA Pubs

A wide range of protein acyl modifications has been identified on enzymes across various metabolic processes; however, the impact of these modifications remains poorly understood. Protein glutarylation is a recently identified modification that can be nonenzymatically driven by glutaryl-CoA. In mammalian systems, this unique metabolite is only produced in the lysine and tryptophan oxidative pathways. To better understand the biology of protein glutarylation, we studied the relationship between enzymes within the lysine/tryptophan catabolic pathways, protein glutarylation, and regulation by the deglutarylating enzyme sirtuin 5 (SIRT5). Here, we identify glutarylation on the lysine oxidation pathway enzyme glutaryl-CoA dehydrogenase (GCDH) and show …

Assessment Of A Novel Commercial Large Field Of View Phantom For Comprehensive Mr Imaging Quality Assurance Of A 0.35t Mrgrt System, Benjamin C Lewis, Jaeik Shin, Borna Maraghechi, Benjamin Quinn, Mike Cole, Enzo Barberi, Jin Sung Kim, Olga Green, Taeho Kim

2020-Current year OA Pubs

Consistent quality assurance (QA) programs are vital to MR-guided radiotherapy (MRgRT), for ensuring treatment is delivered accurately and the onboard MRI system is providing the expected image quality. However, daily imaging QA with a dedicated phantom is not common at many MRgRT centers, especially with large phantoms that cover a field of view (FOV), similar to the human torso. This work presents the first clinical experience with a purpose-built phantom for large FOV daily and periodic comprehensive quality assurance (QUASAR™ MRgRT Insight Phantom (beta)) from Modus Medical Devices Inc. (Modus QA) on an MRgRT system. A monthly American College of …