Digital Commons Network^™

Wastewater Surveillance Of Sars-Cov-2 On American University Campuses: A Comparison Of Responses To The Covid-19 Pandemic, Emily Gosnell

Senior Theses

Wastewater surveillance has been used for a variety of purposes but, in recent years, has most notably been utilized during the COVID-19 pandemic. Many universities in the United States used it as a means of monitoring levels of the SARS-CoV-2 virus on their campuses. The University of South Carolina, University of Arizona, and University of North Carolina- Charlotte were three such schools. An analysis of data published by these three schools has been used to synthesize a proposed list of best methods to be used by other universities during the reemergence of SARS-CoV-2 or during the outbreak of a new …

The Role Of Mediator Kinases Cdk8/19 In The Acquired Resistance To Cdk4/6 Targeting Drugs In Breast Cancer, Kaitlyn Digsby

Senior Theses

Breast cancer remains the highest cause of worldwide cancer-related mortality. Unfortunately, acquired therapeutic resistance occurs in the majority of cases of estrogen receptor-positive breast cancer. An effort to discover drugs which act synergistically with Palbociclib and prevent the development of resistance and tumor growth is essential to improving patient outcomes. Cyclin dependent kinases (CDK) 8 and 19 are Mediator complex proteins. The Mediator complex is an enzymatic module regulating transcription. The goal of the research is to elucidate the mechanism by which CDK8/19 inhibitor, SNX631, prevents acquired resistance to CDK4/6 inhibitor, Palbociclib. The present study aims to elucidate the role …

Promoting Psychological Resilience In Healthcare Workers In Times Of Crisis: Lessons Learned From The Covid-19 Pandemic, Callie Shirley

Senior Theses

HIV-related services have been interrupted by the COVID-19 pandemic in South Carolina (SC). However, many HIV care facilities demonstrated their organizational resilience in adapting to new challenges. One facilitator of organizational resilience, psychological resilience, has become increasingly studied in the health area during the COVID-19 pandemic due to the heightened burdens placed on healthcare workers. Psychological resilience in regard to healthcare facilities is defined as the ability of the health workforce to adapt to adversity and is beneficial to mental health outcomes of the employees. Current literature on psychological resilience has identified facilitators such as support from leadership, a positive …

The Impact Of Transfer Spending In Expediting Improvement Of On-Field Performance Of English Premier League Clubs, Brendan Merten

Senior Theses

This thesis analyzes transfer spending and performance data from English Premier League football clubs participating in the 1992-2021 seasons of the English Premier League using regression analysis and Granger causality analysis. The analysis attempts to extend existing research that indicates a significant causal relationship between transfer spending and performance. I then speak to the sustainability of transfer spending necessary to improve performance over a specified length of time. Further discussion considers implications of Financial Fair Play regulations and explores relevant case studies of Blackburn Rovers, Manchester City, Chelsea, Leicester City, and Newcastle United.

Green Growth Or Degrowth? The Economics Of Climate Change, Cadence Tomlinson

Senior Theses

The paradigm dominating how American policymakers currently approach the climate crisis issue is green growth, positing that the global economy can maintain desirable levels of persistent economic growth while also effectively reducing carbon emissions and slowing the process of global warming, all by means of market-spurred technological innovation and green production processes. Some environmental thinkers dispute the sustainability potential of green growth, urging green growth economists and policymakers to think beyond the ostensibly “limiting” economic growth paradigm. Among this dissent, a new paradigm has emerged, one de-centering goals of economic growth and instead advocating for a reduction in economic throughput, …

Monopolies, Monopsonies, And Everything In-Between: The Gradual Unwinding Of Nearly A Century Of Antitrust Activity, Chase Faulkner

Senior Theses

Changes in the interpretation of antitrust law since the Reagan administration have created a simultaneous increase in mergers/acquisitions and a decrease in antitrust action. This trend started with Ronald Reagan in an effort to bolster a stagnant United States economy, yet in spite of the revolution the global economy has undergone in the last few decades, this trend is still perpetuated today. While this has helped the United States economy abroad, it has come at a cost domestically. A number of industries have become dominated by a single firm (or a group) through a variety of anticompetitive practices, and their …

The Aftereffects Of Corporal Punishment On Adults: Association Of Childhood Spanking With Adult Stress Levels, Marie Sanyang

Senior Theses

Spanking has been an acceptable form of punishment for centuries. Previously thought as effective, studies have now shown the detriments of spanking, including increased aggression, drug abuse, and stress levels. This exploratory study sought to observe the stress levels of adults who experienced childhood spankings. It was hypothesized that those who experienced frequent spankings would report increased anxiety, reduced socialization, and decreased emotional regulation in times of stress. It was also hypothesized that those who reported being spanked would report lower emotional and physical health regulation and higher mental health diagnosis. Fifty-four participants were composed of undergraduate and graduate students …

Mobile Sports Gambling In South Carolina, Drew Pechulonis

Senior Theses

After the U.S. Supreme Court deemed the Professional and Amateur Sports Protection Act (PASPA), sports betting has expanded across the country at a rapid pace. As the sports gambling industry continues to grow, states that have not passed legislation are left wondering whether legalization would benefit their constituents.

The purpose of this study is to determine the feasibility and consequences of legalizing mobile sports gambling in the state of South Carolina. This study can inform state leaders on how to implement mobile sports gambling in the state as well as the positive and negative repercussions that would follow legislation. As …

The Effect Of Provider-Patient Racial Concordance On Student Health Services, Sophia B. Gilliam

Senior Theses

Objective: This research aimed to evaluate the effect of provider-patient racial concordance on perceived care received by University of South Carolina students at Student Health Services.

Methods: A total of 173 students at the University of South Carolina Columbia campus who have received care from Student Health Services within the past 2 years participated in the study. Participants were questioned about their experience with Student Health Services using an adaptation of the CAHPS® Clinician & Group Survey Version 3.0. Independent samples t-tests and descriptive analyses were used for comparisons between the 25 non-white respondents and a randomly selected proportionate group …

Yield Generation Using Decentralized Financial (Defi) Applications, Nathan Walton

Senior Theses

Decentralized financial (DeFi) applications are a new generation of financial service applications, composed of coded smart contracts, and deployed on a blockchain network. These applications offer several methods of generating yield on deposited funds, much like a traditional bank. In this paper I provide a definition of several key terms and a breakdown of the primary mechanisms through which yield is generated. Additionally, I examine three of the main types of DeFi applications, the services they provide, and how they execute these services. I then provide an overview of four strategies involving cash and leverage and estimate the potential benefits …

Covid-19 & Mental Health: The Impact On The Future Of Younger Generations, Greyson A. Fox Tran

Senior Theses

The aim of this research is to identify any existing correlations between the COVID-19 pandemic and negative mental health outcomes in younger populations. This paper examines the impact of the COVID-19 pandemic on the mental health of those younger than 25 years of age, specifically focusing on students. It will investigate how various factors of the pandemic have affected people and how they have coped with psychological distress induced by the pandemic. Through a review of scientific data and scholarly literature, the impacts of the pandemic on mental health will be assessed. Coping mechanisms and the effects of physical activity …

The Impact Of Cultural Perceptions Of Well-Being And Resulting Sustainable Local Development Initiatives, Atifah Jatoi

Senior Theses

Views on and approaches to sustainable economic development can differ vastly depending on country and location. Historically, in the United States, sustainable development is primarily based on the four pillars of sustainability: social, human, environmental, and economic. On the other hand, in communities in relatively collectivist societies, sustainable development policies and organizations are influenced by collective interest, cooperation, and the well-being of the community. Local development initiatives centered around promoting the well-being of the community are a way to have a more equitable approach to sustainable development and are necessary to address ecological, economic, and social challenges. I will discuss …

The Collegiate Dancer As An Athlete: An Argument For Athletic Strength & Conditioning In Collegiate Dance Programs, Samantha Phillips

Senior Theses

Most collegiate sports athletes participate in compulsory athletic strength and conditioning; however, such requirements are not prevalent in university dance programs. Designed as arts degree programs, most requirements revolve around technique, history, pedagogy, theoretical understandings of composition, rehearsals, dance anatomy, and in certain cognates, education. The growing incorporation and paradigm shift of dance as a sport, as well as an art, supports the inclusion of collegiate dance programs into similar considerations, regulations, and requirements as competitive collegiate sports teams. As such, this is an argument and recommendation for the inclusion of athletic strength and conditioning in collegiate dance programs.

Transdisciplinary Environmental Work: An Evaluation Of Transdisciplinarity In The Field Of Environmental Science And Its Relevance To South Carolina Conservation Efforts In Lake Wateree And The Catawba Indian Reservation, Olivia Mn Shugart

Senior Theses

Transdisciplinarity describes the integration of knowledge and exchange of ideas across diverse academic disciplines, public stakeholders, and decision-makers. In this paper, I discuss the relevance of transdisciplinarity to the environmental field and offer ways in which its principles could be employed to enhance current South Carolina conservation efforts. I advocate for transdisciplinary work through analyzing existing discourse on the value of transdisciplinary research to the environmental field, and I present some of the challenges associated with this mass integration of knowledge. Finally, I describe three models of transdisciplinary research that have been proposed by scholars to address some of these …

Slow Violence And Racial Capitalism: Understanding Mass Incarceration Through A Case Study Of The California Prison System, Mason Joiner

Senior Theses

This thesis will analyze the growth of the California prison system, situating it in the national context of mass incarceration in the United States. In Ruth Wilson Gilmore’s book Golden Gulag: Prisons, Surplus, Crisis, and Opposition in Globalizing California, Gilmore utilizes the theory of racial capitalism to explain the history and development of the California prison system. By analyzing Gilmore’s arguments about racial capitalism and integrating them with Rob Nixon’s theory of slow violence from his book Slow Violence and the Environmentalism of the Poor, this thesis provides a new perspective in the current discourse around mass incarceration. …

Acute Kynurenine Challenge Upregulates Activation Of Orexinergic Neurons In The Lateral Hypothalamus, Hayley Nicholson

Senior Theses

Abnormalities in the kynurenic pathway (KP) of tryptophan catabolism are implicated in various neurocognitive disorders, including schizophrenia, bipolar disorder, and Alzheimer’s disease. Elevated levels of the astrocyte-derived metabolite kynurenic acid (KYNA) are found in the postmortem brain of individuals with these illnesses. KYNA is a neuroactive metabolite and acts as an antagonist at glutamatergic N-methyl-D-aspartate (NMDA) and cholinergic α7 nicotinic acetylcholine (α7nACh) receptors. As glutamatergic and cholinergic transmission are critically involved in sleep-dependent plasticity and cognition, KYNA is hypothesized to play a key role in cognitive and sleep disruptions present in these brain disorders. Sleep and cognitive disturbances are pathophysiologically …

German And Mexican Music In Central Texas: Historical Connections And Present Possibilities, Amy Aline Beckman

Masters Theses

German and Mexican music have a shared musical ancestry due to immigrants interacting since the late 1800s in central Texas. Comparing these genres reveals both commonalities and distinctions regarding style, orchestration, and thematic material. The differences between the genres create cultural boundaries reflecting nationalism that sometimes reinforces racial tension, while the commonalities are opportunities for empathy and open-mindedness through the globalization that occurs from shared musical experiences. While the historical connections between Germans and Mexicans in Central Texas are well-documented, the present-day status and effects of these connections have not been researched thoroughly. This project builds cultural profiles of both …

Mislabeled: A Study Of Generational Labels And Gen Z Stereotypes, Levi Victor Smith

Masters Theses

Generation Z is the newest cohort to be introduced in the generational cycle and has earned the attention of marketers, researchers, and the general public alike. While individuals and members of other generations have been quick to stereotype and assign labels to members of Generation Z, little research has been done to see if such labels are accurate. Therefore, the purpose of this study was to discover whether generational labels can accurately communicate the characteristics of individuals within Generation Z. This study used Henri Tajfel's and John Turner’s Social Identity Theory to examine how group membership defines self-identity in terms …

A Course To Prepare Undergraduate Music Education Students For Teaching Autism Spectrum Disorder, Amanda Lynn Whitmer

Masters Theses

In the field of music education, Autism Spectrum Disorder has become an area of importance requiring more thought and intentionality from teachers than normal lesson planning expectations. Because music educator programs only offer courses that cover the whole spectrum of special needs and do not focus on autism specifically, music educators are finding themselves unprepared to create music lessons that can accommodate learners with such a unique spectrum of learning abilities. Many college curriculums offer special needs courses that focus on all aspects of special education that can be found in music education but very rarely for autism as a …

Racial Allies, Atinuke O. Adediran

Fordham Law Review

Racial allies are white individuals and institutions that actively work to dismantle systems of racial inequality and the consequences of poverty that disproportionately impact communities of color and that are willing to both confer and share power with members of subjugated groups. There is no other sector of the legal profession that professes to be racial allies more than individuals and institutions within the public interest law sector. Yet, these institutions that address structural racism and disproportionately serve communities of color appear not to share power with racial and ethnic minorities. The public interest law sector has been at the …

The Political And Social Change Driven By Protest: The Need To Reform The Anti-Riot Act And Examine Anti-Riot Provisions, Ronald E. Britt Ii

Fordham Law Review

The right to join in peaceful assembly and petition is critical to an effective democracy and is at the core of the First Amendment. The assault of peaceful protestors in the pursuit of racial justice is not a new phenomenon, and legislators at the federal and state levels have drafted anti-riot provisions as a measure to target protestors they deem an existential threat to American society. As these provisions have become increasingly prevalent in light of the protests following the murders of Breonna Taylor and George Floyd, they have the likelihood of severely chilling the effect on protestors’ right to …

Jefferson Digital Commons Quarterly Report: January-March 2022, Larissa Gordon, Mslis, Med, Ma

Jefferson Digital Commons Reports

In this Issue:

• Articles
• Thesis/Dissertations
• Grand Rounds and Lectures
• Capstone Presentations
• Journals and Newsletters
• Posters
• Miscellaneous
• What People are Saying About the Jefferson Digital Commons

Adolescent Hiv Pre Exposure Prophylaxis Prescribing Practices Among Family Medicine Physicians: Limited Immediate Uptake, Marshal Miller, E. Cooper, S. Elsesser, A. Cunningham

Department of Family & Community Medicine Posters

This study aims to:

• Examine the adolescent PrEP prescribing practices and knowledge of family medicine physicians.
• Begin to identify areas that might be key targets for interventions which may lead to increased adolescent PrEP prescribing uptake.

Serine-Threonine Kinase Inhibition As Antifibrotic Therapy: Transforming Growth Factor-Β And Rho Kinase Inhibitors, Fabian A. Mendoza, Sergio A. Jimenez

Scleroderma Center Faculty Papers

Serine/threonine kinases mediate the phosphorylation of intracellular protein targets, transferring a phosphorus group from an adenosine triphosphate molecule to the specific amino acid residues within the target proteins. Serine/threonine kinases regulate multiple key cellular functions. From this large group of kinases, TGF-β through serine/threonine activity of its receptors and Rho kinase (ROCK) play an important role in the development and maintenance of fibrosis in various human diseases, including SSc. In recent years, multiple drugs targeting and inhibiting these kinases have been developed, opening the possibility of becoming potential antifibrotic agents of clinical value for treating fibrotic diseases. This review analyses …

Forage News [2022-04], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

No abstract provided.

Forensic Science In Legal Education, Brandon L. Garrett, Glinda S. Cooper, Quinn Beckham

The Journal of Law and Education

No abstract provided.

Surviving Recission: Refining The 2020 Final Title Ix Regulations' Cross-Examination Requirement To Balance The Interests Of Complainants And Respondents, Samantha J. Doward

The Journal of Law and Education

No abstract provided.

Rights To Nowhere: The Idea's Inadequacy In High-Poverty Schools, Claire Raj

Faculty Publications

The Individuals with Disabilities Education Act (“IDEA”) successfully opened the schoolhouse doors to millions of students with disabilities. But more than forty years after its enactment, the law has proven largely inept at confronting the educational inequities faced by the many students with disabilities attending underfunded, high-poverty public schools. This shortcoming is inconsistent with common conceptions of the IDEA: Advocates and policymakers alike treat the IDEA’s rights and privately enforceable remedies as strong, meaningful tools. This Article theorizes that the IDEA’s under-appreciated failures are overlooked because they are the products of the law’s internal structure, undue judicial deference to schools, …

The Dental Health Of Rural Elderly People And Its Social Justice Implications, Health In The Hills: Understanding The Impact Of Health Care Law In Rural Communities, Jacqueline R. Fox

Faculty Publications

No abstract provided.

A Geospatial And Binomial Logistic Regression Model To Prioritize Sampling For Per- And Polyfluorinated Alkyl Substances In Public Water Systems, Sweta Ojha, Ying Li, Nader Rezaei, Ariel Robinson, Anna G. Hoover, Kelly G. Pennell

UK CARES Faculty Publications

As health‐based drinking water standards for per‐ and polyfluorinated alkyl substances (PFAS) continue to evolve, public health and environmental protection decision‐makers must assess exposure risks associated with all public drinking water systems in the United States (US). Unfortunately, current knowledge regarding the presence of PFAS in environmental systems is limited. In this study, a screening approach was established to: (1) identify and direct attention toward potential PFAS hot spots in drinking water sources, (2) prioritize sampling locations, and (3) provide insights regarding the potential PFAS sources that contaminate groundwater and surface water. Our approach incorporates geospatial data from public sources, …