Digital Commons Network^™

Subdivision Site Design In Antwerp Township, Peyton Smith

Honors Theses

Design and development of a subdivision on an empty plot of land off Red Arrow Highway in Antwerp Township, MI.

Comparison Of Bio-Mass To Bio-Oil Reactor Systems: Direct Conversion Vs. Companion Coal Gasification, Luci Evans

Honors Theses

The purpose of this project was to define, design, and optimize the economic feasibility of the production of bio-oil from a direct conversion of biomass to bio-oil using fast pyrolysis and a secondary side reaction of the production of a syngas from coal gasification. In the end, a combined process of these two was created to show the new strengths and more efficient options to produce a desired product within a budget. The main objectives of this project were to research the economic feasibility of the biomass and bio-oil industry, obtain a market survey, design two process flow diagrams showing …

Crossing The Border: A Novel Mouse Line Using Fgf10-Cre To Drive Gata3 Overexpression In Nonsensory Transcriptional Context, Lucas Cunha

Honors Theses

Hearing loss can occur in a variety of ways, and in every case, they have equally devasting effects. While hearing loss and the people who suffer from it shall not be discriminated against, attempting to offer options for treatments nevertheless should be of priority. As such, there has been much progress in the field of genetically based forms of treatment for sensorineural hearing loss. A gene that has been almost always implicated in the conversation of regeneration, Hair Cell and Spiral Ganglia development, and inner ear development, in general, is the Zing Finger transcription factorsGata3. Furthermore, since the Organ of …

Composting During Winter Versus Summer: A Microbial Analysis, Madison Ochs

Honors Theses

Pre-consumer food waste, hay, and woodchips were composted using two different methods of static composting: forced aeration (FA) and natural aeration (NA). The composting process was performed during the winter and summer for 106 and 124 days, respectively. The composting process for both winter and summer processes did not reach the temperature above the 40°C threshold of the thermophilic stage in composting. The microbial communities present during different timepoints (start, peak, and final) along the composting process were analyzed with DNA sequencing techniques and visualized using QIIME 2, an open-source bioinformatics platform. The microbial communities of the winter and summer …

Successful Components For Developing An Oncology Nurse Residency Program: An Integrative Review, Andi Johnson

Master of Science in Nursing Final Projects

Problem Identification

Residency programs for newly licensed registered nurses (NLRNs) have become an integral part of the new nurse’s transition to professional practice, improving resilience and retention of the NLRN. The goal of this integrative review is to highlight concepts and components that have been successfully incorporated into NLRN residencies and provide nursing leaders with actionable guidance to incorporate into facility-based oncology nurse residencies.

Literature Search

An integrative review using Whittemore and Knafl’s approach was conducted in accordance with principles of thematic analysis established by Toronto and Remington.

Data Evaluation

Eighteen records were included. As few research articles were found …

The Prospector, April 19, 2022, Utep Student Publications

The Prospector

Headline: "Into the Woods"

Examining Nurse Engagement In Antimicrobial Stewardship At Long-Term Care Facilities, Mosam S. Patel, Kathryn L. Dambrino, Olivia Bahemuka, David Phillippi

DNP Projects

Background: The World Health Organization stated that antimicrobial resistance is one of the top 10 threats to global health. To combat antimicrobial resistance, antimicrobial stewardship (AMS) programs were developed. Efforts to engage nurses in stewardship efforts have been limited. Bedside nurses are in an optimal position to help decrease antimicrobial use, which is especially relevant in long-term care facilities where up to 75% of antibiotic use is deemed unnecessary or inappropriate. The purpose of this Doctor of Nursing Practice scholarly project was to examine factors that influence nurse engagement in AMS at long-term care facilities in Tennessee. Methods: A …

Interprofessional Socialization Of Nursing Students After Participating In Interdisciplinary Rounds In An Intensive Care Unit, Ashlyn S. Upshaw

DNP Projects

Background: Nursing engagement in interprofessional collaboration leads to safe and quality healthcare for patients. In order to effectively engage in interprofessional collaboration, nursing students must socialize among healthcare providers from various disciplines. Purpose: The purpose of this project was to examine pre-licensure nursing students’ beliefs and attitudes towards interprofessional socialization and collaboration following their participation in interdisciplinary rounds in an intensive care unit (ICU) setting. Methods: A mixed-methods, cross-sectional design was used to collect data from undergraduate nursing students at a private university. Following an ICU clinical rotation, participants completed the Interprofessional Socialization and Valuing Survey-21 (ISVS-21) …

Effects Of Interdisciplinary Instruction On Students' Connection Of Knowledge Across Learning Domains, Karley Becker

Honors Projects

This research examines the use of interdisciplinary instruction in the early education classroom and how it impacts students' connection of knowledge across learning domains. This study looks specifically at a second-grade classroom in a midwestern state. The primary learning domains of social studies, science, mathematics, and language arts were focused on. The study is broken up into two phases: observation and implementation. Prior to the observation phase, a four-part interdisciplinary lesson plan on dinosaurs was created, including transition activities, vocabulary, state standards, and activities. After the creation of the lesson plans, the observation phase took place in which a typical …

Plant Wise, Sophia Llamas

Honors Projects

Conceptually, Plant Wise is the key to bridging the gap between preconceived ideas about vegan and vegetarianism and successfully integrating plant-based foods into your everyday life. Physically, Plant Wise is a self-educational, interactive booklet chock-full of activities intended for users to complete at their own pace. Inside this 56-page booklet, there are recipes, doodling spaces, weekly check sheets, activities to do with friends and family, challenges, and so much more. Plant Wise utilizes these activities and journaling opportunities throughout as a self-reflective vehicle to give users an experience to reflect on, which aids in the retention of what’s been learned …

Executive Committee - Agenda 4/19/2022, Academic Senate

Academic Senate Agendas

No abstract provided.

An Analysis Of The Covid-19 Pandemic On The Students At The University Of South Dakota, Alexandra J. Buss

Honors Thesis

The COVID-19 pandemic rapidly took over the United States (US) in the beginning of 2020. Nationally, damages to finances, housing, and mental health have impacted many. Despite being one of the least densely populated states, South Dakota quickly rose to some of the highest rates in the nation and was identified as a national hotspot. While there have been significant reports on the effects of COVID-19 on certain communities (healthcare workers, small business owners, parents), more research is needed on the effects on university students. In this report, I aim to assess damages based on financial status of students, mental …

Exercise Education Of Western Michigan University Students Who Use The University Recreation Center, Rachael Brewer

Honors Theses

According to the American College of Sports Medicine’s (ACSM) annual survey data, various modalities of resistance training are reported in the top 20 ways to exercise in 2022. According to the Nationwide Children’s Hospital, there has been a significant increase in acute care visits resulting from resistance training as it becomes more common to train without proper professional oversight (Nationwide Children’s Hospital, 2010). Many exercisers watch, replicate, or take advice from friends in the weight room; however, professional instruction is key for a safe workout experience. Injuries can and do occur on resistance machines, treadmills, and stair mills with little …

Electromagnetically Propelled Garage Door, Connor Seifert

Honors Theses

Garage door systems are loud and energy inefficient given their many contact points and need for continual maintenance. Most garage door systems use a loud, bulky electric motor to pull the garage door up and down using a chain. To reduce noise and energy loss due to friction from the electric motor and chain, electromagnetic forces used in Electromagnetic Suspension (EMS) trains were researched and adapted to a garage door system. The electromagnetically propelled garage door (EPGD) system was designed and validated using SOLIDWORKS and ANSYS simulation with significantly less contact points due to non-contact electromagnetic propulsion (EMP). The design …

The 1994 Federal Crime Bill: An Evaluation Of The Past, Present, And Future Of Its Impact On The Criminal Justice System, Jade R. Philpot

Honors College Theses

The 1994 Violent Crime Control and Law Enforcement Act was signed into law in response to the crack cocaine and crime epidemic of the 1980s. In this thesis I address the major elements of this bill, the racial, financial, and ethical conflicts that arose thereafter, and the reforms that should be implemented today to correct said conflicts.

The Mother Of Exiles Is Abandoning Her Children: The Systemic Failure To Protect Unaccompanied Minors Arriving At Our Borders, Rosa M. Peterson

The Scholar: St. Mary's Law Review on Race and Social Justice

Unaccompanied minors arrive at the United States border every day. Many brought by the hope of finding a life lived without fear, a luxury many United States citizens take for granted. Their truths become the barriers and shackles which keep them in detention centers and unaccompanied minor facilities throughout the United States; children find their very words wielded as weapons against them in immigration court. Words often spoken to therapists in perceived confidence, during counseling sessions. This practice is a systemic failure to protect unaccompanied minors arriving at our borders who are seeking protection and help. The United States …

Protecting A Woman’S Right To Abortion During A Public Health Crisis, San Juanita Gonzalez

The Scholar: St. Mary's Law Review on Race and Social Justice

As COVID-19 infected our nation, states were quick to issue executive orders restricting various aspects of daily life under the pretense of public safety. It was clear at the outset that certain civil liberties were going to be tested. Among them, the constitutional right to an abortion.

This comment explores Texas’ response to the COVID-19 pandemic and the limitations it imposed on abortion access. It will attempt to address the legitimacy of the “public health concerns” listed in executive orders issued throughout numerous states and will discuss the pertinent legal framework and judicial scrutiny to apply.

According to the Fifth …

Telerehabilitation For Physical Disabilities And Movement Impairment: A Service Evaluation In South West England, Sarah A. Buckingham, Kim Sein, Krithika Anil, Sara Demain, Hilary Gunn, Ray B. Jones, Bridie Kent, Angela Logan, Jonathan Marsden, E. D. Playford, Jenny Freeman

School of Nursing and Midwifery

No abstract provided.

Hereditary Retinoblastoma Ipsc Model Reveals Aberrant Spliceosome Function Driving Bone Malignancies, Jian Tu, Zijun Huo, Yao Yu, Dandan Zhu, An Xu, Mo-Fan Huang, Ruifeng Hu, Ruoyu Wang, Julian A Gingold, Yi-Hung Chen, Kuang-Lei Tsai, Nicolas R Forcioli-Conti, Sarah X L Huang, Thomas R Webb, Jie Su, Danielle A Bazer, Peilin Jia, Jason T Yustein, Lisa L Wang, Mien-Chie Hung, Zhongming Zhao, Chad D Huff, Jingnan Shen, Ruiying Zhao, Dung-Fang Lee

Faculty, Staff and Student Publications

The RB1 gene is frequently mutated in human cancers but its role in tumorigenesis remains incompletely defined. Using an induced pluripotent stem cell (iPSC) model of hereditary retinoblastoma (RB), we report that the spliceosome is an up-regulated target responding to oncogenic stress in RB1-mutant cells. By investigating transcriptomes and genome occupancies in RB iPSC–derived osteoblasts (OBs), we discover that both E2F3a, which mediates spliceosomal gene expression, and pRB, which antagonizes E2F3a, coregulate more than one-third of spliceosomal genes by cobinding to their promoters or enhancers. Pharmacological inhibition of the spliceosome in RB1-mutant cells leads to global intron retention, decreased cell …

Ror Activation By Nobiletin Enhances Antitumor Efficacy Via Suppression Of Iκb/Nf-Κb Signaling In Triple-Negative Breast Cancer, Eunju Kim, Yoon-Jin Kim, Zhiwei Ji, Jin Muk Kang, Marvin Wirianto, Keshav Raj Paudel, Joshua A Smith, Kaori Ono, Jin-Ah Kim, Kristin Eckel-Mahan, Xiaobo Zhou, Hyun Kyoung Lee, Ji Young Yoo, Seung-Hee Yoo, Zheng Chen

Faculty, Staff and Student Publications

Triple-negative breast cancer (TNBC) is a heterogeneous disease characterized by poor response to standard therapies and therefore unfavorable clinical outcomes. Better understanding of TNBC and new therapeutic strategies are urgently needed. ROR nuclear receptors are multifunctional transcription factors with important roles in circadian pathways and other processes including immunity and tumorigenesis. Nobiletin (NOB) is a natural compound known to display anticancer effects, and our previous studies showed that NOB activates RORs to enhance circadian rhythms and promote physiological fitness in mice. Here, we identified several TNBC cell lines being sensitive to NOB, by itself or in combination. Cell and xenograft …

An Analysis Of The Diversity And Inclusion Content Featured On Ophthalmology Residency Program Web Sites, Samuel A. Cohen, Landon E. Cohen, Suzann Pershing

Journal of Academic Ophthalmology

Abstract

Introduction Ophthalmology departments have been stated to be among the least diverse clinical departments at United States medical schools. Improvement requires recruiting a pipeline of diverse trainees. Residency program Web sites represent a potential diversity and inclusion recruitment tool. This study assesses how ophthalmology residency program Web sites demonstrate a commitment to diversity and inclusion.

Methods We analyzed the diversity and inclusion content of 116 ophthalmology residency program Web sites in April 2021. Main outcome measures were the presence of 12 diversity and inclusion elements on program Web sites, based on prior work and Accreditation Council for Graduate Medical …

The Effect Of Using The Adaptive Crawler™ On The Development Of Infants With Spina Bifida, Age 6-12 Months, Margaret E. Williams

Dissertations

During the timeframe of crawling, age 6--12 months, infants typically interact independently with their environment and their parents in order to perform certain developmental tasks. However, many infants with spina bifida are unable to crawl, as would typically developing infants. The inability to crawl may place these infants at a distinct disadvantage during this developmental timeframe. As a result of the developmental disadvantage, the parent-infant relationship may be negatively affected. For this study, the Adaptive Crawler™ assistive technology infant mobility device was designed, and a prototype created, to promote independent mobility and exploration of their environment by infants with spina …

Mindfulness And Observational Drawing, Corinne Christopherson Sonderegger

Theses and Dissertations

Observational drawing has many benefits, yet it can be a difficult and frustrating curriculum for students and teachers alike. As I was teaching elementary and college art classes simultaneously, I noticed a significant discrepancy between my younger and older students. Students in my elementary art classes loved to draw and often expressed how excited they were to make art. However, students in my college art classes were more hesitant and self-conscious about drawing and did not believe they could progress artistically. Many of these students had abandoned drawing in elementary or middle school. This pattern evokes the U curve of …

Hyperactivation Is Sufficient To Release Porcine Sperm From Immobilized Oviduct Glycans, Momal Sharif, Vincent Hickl, Gabriel Juarez, Xingjian Di, Karl Kerns, Peter Sutovsky, Nicolai Bovin, David J Miller

Faculty, Staff and Students Publications

Fertilizing sperm are retained by adhesion to specific glycans on the epithelium of the oviduct forming a reservoir before sperm are released from the reservoir so fertilization can ensue. Capacitated sperm lose affinity for the oviduct epithelium but the components of capacitation that are important for sperm release are uncertain. One important correlate of capacitation is the development of hyperactivated motility. Hyperactivation is characterized by asymmetrical flagellar beating with high beat amplitude. We tested whether the development of full-type asymmetrical motility was sufficient to release sperm from immobilized oviduct glycans. Sperm hyperactivation was induced by four different compounds, a cell-permeable …

Safety And Efficacy Of Systemic Anti-Scg3 Therapy To Treat Oxygen-Induced Retinopathy, Chang Dai, Hong Tian, Amit Bhatt, Guanfang Su, Keith A Webster, Wei Li

Faculty, Staff and Students Publications

BACKGROUND: To circumvent possible systemic side effects, anti-angiogenic drugs targeting vascular endothelial growth factor (VEGF) for ocular neovascular diseases in adults are approved only for intravitreal administration. However, intravitreal injection itself can elicit injection-related adverse effects, and premature eyes of infants with retinopathy of prematurity (ROP) may be particularly susceptible to intravitreal injection. Therefore, an unmet clinical need is to develop safe systemic anti-angiogenic therapies for ROP. We recently reported that secretogranin III (Scg3) is a disease-restricted angiogenic factor and that systemic anti-Scg3 mAb alleviates ROP in animal models with minimal side effects on developing eyes and organs. The aim …

Centrosome-Dependent Microtubule Modifications Set The Conditions For Axon Formation, Durga Praveen Meka, Ewelina Betleja, Tao Cheng, Moe R Mahjoub, Et Al.

2020-Current year OA Pubs

Microtubule (MT) modifications are critical during axon development, with stable MTs populating the axon. How these modifications are spatially coordinated is unclear. Here, via high-resolution microscopy, we show that early developing neurons have fewer somatic acetylated MTs restricted near the centrosome. At later stages, however, acetylated MTs spread out in soma and concentrate in growing axon. Live imaging in early plated neurons of the MT plus-end protein, EB3, show increased displacement and growth rate near the MTOC, suggesting local differences that might support axon selection. Moreover, F-actin disruption in early developing neurons, which show fewer somatic acetylated MTs, does not …

Relationship Between Age At Menopause, Obesity, And Incident Heart Failure: The Atherosclerosis Risk In Communities Study, Imo A Ebong, Machelle D Wilson, Duke Appiah, Erin D Michos, Susan B Racette, Amparo Villablanca, Khadijah Breathett, Pamela L Lutsey, Melissa Wellons, Karol E Watson, Patricia Chang, Alain G Bertoni

2020-Current year OA Pubs

Background The mechanisms linking menopausal age and heart failure (HF) incidence are controversial. We investigated for heterogeneity by obesity on the relationship between menopausal age and HF incidence. Methods and Results Using postmenopausal women who attended the Atherosclerosis Risk in Communities Study Visit 4, we estimated hazard ratios of incident HF associated with menopausal age using Cox proportional hazards models, testing for effect modification by obesity and adjusting for HF risk factors. Women were categorized by menopausal age: <45 years, 45 to 49 years, 50 to 54 years, and ≥55 years. Among 4441 postmenopausal women, aged 63.5±5.5 years, there were 903 incident HF events over a mean follow-up of 16.5 years. The attributable risk of generalized and central obesity for HF incidence was greatest among women who experienced menopause at age ≥55 years: 11.09/1000 person-years and 7.38/1000 person-years, respectively. There were significant interactions of menopausal age with body mass index and waist circumference for HF incidence,

Youth Empowerment: Case Study And Learning Strategy, Andrew Blum, Nohelia Ramos

Kroc IPJ Research and Resources

The U.S. Department of Justice’s Project Safe Neighborhoods (PSN) is invested in preventing violence and reducing recidivism. To achieve these objectives, PSN has committed to supporting lived experience mentoring, often called credible messenger mentoring, through grants made to community organizations in San Diego and Imperial Counties.

This document consists of two separate research products that align with these two objectives. The first is a case study of Youth Empowerment. The case study has several goals: first, to document the work of Youth Empowerment and allow others to learn in a detailed way about lived experience programming; second, to place the …

Anisotropic Colloidal Particles Near Boundaries, Jiarui Yan, Christopher L. Wirth

Faculty Scholarship

Anisotropic colloidal particles are regularly found in applications ranging from health to energy. These particles, typically with non-uniform shape or surface chemistry, interact with boundaries in unique ways, offering pathways to complex assemblies and active systems. Work in this field over the past two decades rapidly advanced, with the last five years seeing significant innovation. One common thread joining many studies and applications is that of the presence of boundaries in the form of a nearby wall or neighboring particle. Asymmetry introduced by a neighboring boundary often leads to unique and surprising particle dynamics from the resulting anisotropic surface interactions. …

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