Digital Commons Network^™

Approved Programs 4/19/22, Angela Brock

Programs Committee (PC)

No abstract provided.

Home And Environmental Modifications And Community Resources For Individuals With Visual Impairment, Kimberly Mclaughlin

OTD Capstone Projects

Tucker's House is a non-profit organization that provides home and environmental modifications as well as assistive devices to families in Middle Tennessee that have a child with a disability. This doctoral capstone project focused on developing resources the organization can provide to individuals with low vision, visual impairment or blindness as well as their families/caregivers. The resources created include family intake forms, adaptive devices and durable medical equipment lists, community resources, general strategies, and smartphone/technology accessibility guides all related to increasing safety, participation in daily living tasks, and independence for individuals with visual impairment.

Center For Practical Ethics Restarts Policy Talks Series, Edwin B. Smith

University of Mississippi News

Thursday event to examine role of big data and tech and how they affect rural health care and policy

Identity Documents For Transgender Texans: A Proposal For A Uniform System For Correcting Gender Markers In Texas, Lydia R. Harris

The Scholar: St. Mary's Law Review on Race and Social Justice

Texas’s lack of a codified gender correction process is unjust, illegal, and against public policy. This comment highlights the injustice faced by transgender Texans without gender concordant identity documents. These injustices include discrimination based on gender stereotypes, violation of the transgender individual’s right to privacy, and violations of public policy. This comment explores possible solutions to the injustices faced by transgender Texans due to the lack of a codified uniform way to correct gender markers in Texas modeled on other jurisdictions’ approaches to this problem.

First, this comment traces the history of the recognition of transgender people and transgender rights …

Microscopic Nuclei Classification, Segmentation, And Detection With Improved Deep Convolutional Neural Networks (Dcnn), Md Zahangir Alom, Vijayan K. Asari, Anil Parwani, Tarek M. Taha

Electrical and Computer Engineering Faculty Publications

Background Nuclei classification, segmentation, and detection from pathological images are challenging tasks due to cellular heterogeneity in the Whole Slide Images (WSI). Methods In this work, we propose advanced DCNN models for nuclei classification, segmentation, and detection tasks. The Densely Connected Neural Network (DCNN) and Densely Connected Recurrent Convolutional Network (DCRN) models are applied for the nuclei classification tasks. The Recurrent Residual U-Net (R2U-Net) and the R2UNet-based regression model named the University of Dayton Net (UD-Net) are applied for nuclei segmentation and detection tasks respectively. The experiments are conducted on publicly available datasets, including Routine Colon Cancer (RCC) classification and …

Mental Disorder Symptoms During The Covid-19 Pandemic In Latin America – A Systematic Review And Meta-Analysis, Stephen X. Zhang, Kavita Batra, Wen Xu, Tao Liu, Rebecca Kechen Dong, Allen Yin, Andrew Yilong Delios, Bryan Z. Chen, Richard Z. Chen, Saylor Miller, Xue Wan, Wenping Ye, Jiyao Chen

School of Medicine Faculty Research

Aims There is a lack of evidence related to the prevalence of mental health symptoms as well as their heterogeneities during the coronavirus disease 2019 (COVID-19) pandemic in Latin America, a large area spanning the equator. The current study aims to provide meta-analytical evidence on mental health symptoms during COVID-19 among frontline healthcare workers, general healthcare workers, the general population and university students in Latin America. Methods Bibliographical databases, such as PubMed, Embase, Web of Science, PsycINFO and medRxiv, were systematically searched to identify pertinent studies up to August 13, 2021. Two coders performed the screening using predefined eligibility criteria. …

Training The Next Generation Of Translational Scientists: The Case Western Reserve University Translational Fellows Program, Cheryl L. Thompson, Tessianna A. Misko, Mark R. Chance

Faculty Scholarship

Background: An important part of biomedical research is the translation of discoveries into clinical or community applications that impact patient health. For a vast majority of clinical applications and sustainable community interventions, a time-tested way to get innovations to patients is through licensing of the technology and commercial development, often through startups. While biomedical scientists and trainees are schooled in discovery research, the processes of commercialization are foreign or intimidating. Further, many trainees will not aspire to a faculty position, and other avenues of advancement are desirable. Methods: At Case Western Reserve University, we developed and launched a Translational Fellows …

Editorial: Special Issue “Innovative Techniques And Approaches In The Control And Prevention Of Rabies Virus”, Amy T. Gilbert, Ryan M. Wallace, Charles E. Rupprecht

United States Department of Agriculture Wildlife Services: Staff Publications

Rabies is an ancient lethal scourge that has plagued humankind for centuries. Globally, 60,000 human deaths are estimated to occur each year from rabies virus (RABV) transmission in domestic dogs, mostly affecting children. While rabies is recognized as a neglected disease, there is cause for optimism in the context of growing global recognition, collaboration and commitment to advance a tripartite agenda to eliminate human deaths transmitted from rabid dogs by 2030, also known as “Zero By Thirty” (ZBT). Nevertheless, the ZBT goal must also confront competing challenge(s) of tracking and mitigating human morbidity and mortality during a global pandemic caused …

Safety And Efficacy Of Systemic Anti-Scg3 Therapy To Treat Oxygen-Induced Retinopathy, Chang Dai, Hong Tian, Amit Bhatt, Guanfang Su, Keith A Webster, Wei Li

Faculty, Staff and Students Publications

BACKGROUND: To circumvent possible systemic side effects, anti-angiogenic drugs targeting vascular endothelial growth factor (VEGF) for ocular neovascular diseases in adults are approved only for intravitreal administration. However, intravitreal injection itself can elicit injection-related adverse effects, and premature eyes of infants with retinopathy of prematurity (ROP) may be particularly susceptible to intravitreal injection. Therefore, an unmet clinical need is to develop safe systemic anti-angiogenic therapies for ROP. We recently reported that secretogranin III (Scg3) is a disease-restricted angiogenic factor and that systemic anti-Scg3 mAb alleviates ROP in animal models with minimal side effects on developing eyes and organs. The aim …

Program Review Report 4/19/22, Angela Brock

Program Review Committee

No abstract provided.

Honors Tutorial College Report 4/19/22, Angela Brock

Program Review Committee

No abstract provided.

Reduced Er-Mitochondria Connectivity Promotes Neuroblastoma Multidrug Resistance., Jorida Çoku, David M. Booth, Jan Skoda, Madison C Pedrotty, Jennifer Vogel, Kangning Liu, Annette Vu, Erica L Carpenter, Jamie C Ye, Michelle A Chen, Peter Dunbar, Elizabeth Scadden, Taekyung D Yun, Eiko Nakamaru-Ogiso, Estela Area-Gomez, Yimei Li, Kelly C Goldsmith, C Patrick Reynolds, György Hajnóczky, Michael D Hogarty

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Most cancer deaths result from progression of therapy resistant disease, yet our understanding of this phenotype is limited. Cancer therapies generate stress signals that act upon mitochondria to initiate apoptosis. Mitochondria isolated from neuroblastoma cells were exposed to tBid or Bim, death effectors activated by therapeutic stress. Multidrug-resistant tumor cells obtained from children at relapse had markedly attenuated Bak and Bax oligomerization and cytochrome c release (surrogates for apoptotic commitment) in comparison with patient-matched tumor cells obtained at diagnosis. Electron microscopy identified reduced ER-mitochondria-associated membranes (MAMs; ER-mitochondria contacts, ERMCs) in therapy-resistant cells, and genetically or biochemically reducing MAMs in therapy-sensitive …

Ucc Agenda 4/19/22, Angela Brock

UCC Agendas/Minutes

No abstract provided.

Individual Course Committee Agenda 4/19/22, Angela Brock

Individual Course Committee (ICC)

No abstract provided.

Approved Courses 4/19/22, Angela Brock

Individual Course Committee (ICC)

No abstract provided.

Ucc Minutes 4/19/22, Angela Brock

UCC Agendas/Minutes

No abstract provided.

Exploring The Gap: Positive And Negative Experiences Of The Clinical Nurse Educator, Ariana Johnson

Honors Theses

The overall aim of this thesis is to understand clinical nurse educator experiences. Challenges to retain and recruit nurse educators' limits nursing student enrollment and the ability to meet nursing workforce demands. The American Association of Colleges of Nursing (AACN) factors contributing to nursing faculty shortages guided this thesis research study. Asking research questions, “Describe what you like about being an academic clinical nurse educator” and “Describe what you don’t like about being an academic clinical nurse educator” can support understanding clinical nurse educator positive and negative experiences. A qualitative descriptive study and thematic analysis was conducted. An anonymous 22-question …

The Impacts Of The Covid-19 Pandemic On Airport Demand Forecasts And Critical Aircraft For Commercial Service Airports Serving Southwest Michigan, Matthew Wietstock

Honors Theses

The COVID-19 pandemic has drastically altered the aviation industry and the nature of how airports predict their future use. This paper conducts a new analysis of the various prediction methods regarding airport demand forecasting using the commercial service airports serving Southwest Michigan. Primarily, the methods researched include time-series analysis using regressions, market-share analysis, and an examination of socio-economic factors. While no one method prevails over the other, the market-share analysis has proven to be the most realistic predictor in three of the four airports analyzed, with time-series analysis predicting the other. A thorough analysis of these forecasting methods can help …

The Effect Of Foam-Rolling On Vertical Jump And Range Of Motion Of The Hip And Ankle, Katie Davis

Honors Theses

Foam-rolling (FR) has gained popularity among many fitness enthusiasts, but whether it is beneficial or not is still being investigated. A number of studies researched its effect on recovery for athletes such as runners and bodybuilders, but the effects of the foam-rolling process was only assessed following a workout. This study was designed to evaluate the effect of foam-rolling prior to activity and whether it enhanced performance for a vertical jump and/or range of motion (ROM) in the hip and ankle joints. Thirty-four subjects were recruited from Western Michigan University and performed all necessary conditions in the Human Performance Lab …

Subdivision Site Design In Antwerp Township, Alec Denbraber

Honors Theses

Design and development of a subdivision on an empty plot of land off Red Arrow Highway in Antwerp Township, MI.

Subdivision Site Design In Antwerp Township, Peyton Smith

Honors Theses

Design and development of a subdivision on an empty plot of land off Red Arrow Highway in Antwerp Township, MI.

Comparison Of Bio-Mass To Bio-Oil Reactor Systems: Direct Conversion Vs. Companion Coal Gasification, Luci Evans

Honors Theses

The purpose of this project was to define, design, and optimize the economic feasibility of the production of bio-oil from a direct conversion of biomass to bio-oil using fast pyrolysis and a secondary side reaction of the production of a syngas from coal gasification. In the end, a combined process of these two was created to show the new strengths and more efficient options to produce a desired product within a budget. The main objectives of this project were to research the economic feasibility of the biomass and bio-oil industry, obtain a market survey, design two process flow diagrams showing …

Crossing The Border: A Novel Mouse Line Using Fgf10-Cre To Drive Gata3 Overexpression In Nonsensory Transcriptional Context, Lucas Cunha

Honors Theses

Hearing loss can occur in a variety of ways, and in every case, they have equally devasting effects. While hearing loss and the people who suffer from it shall not be discriminated against, attempting to offer options for treatments nevertheless should be of priority. As such, there has been much progress in the field of genetically based forms of treatment for sensorineural hearing loss. A gene that has been almost always implicated in the conversation of regeneration, Hair Cell and Spiral Ganglia development, and inner ear development, in general, is the Zing Finger transcription factorsGata3. Furthermore, since the Organ of …

Composting During Winter Versus Summer: A Microbial Analysis, Madison Ochs

Honors Theses

Pre-consumer food waste, hay, and woodchips were composted using two different methods of static composting: forced aeration (FA) and natural aeration (NA). The composting process was performed during the winter and summer for 106 and 124 days, respectively. The composting process for both winter and summer processes did not reach the temperature above the 40°C threshold of the thermophilic stage in composting. The microbial communities present during different timepoints (start, peak, and final) along the composting process were analyzed with DNA sequencing techniques and visualized using QIIME 2, an open-source bioinformatics platform. The microbial communities of the winter and summer …

Successful Components For Developing An Oncology Nurse Residency Program: An Integrative Review, Andi Johnson

Master of Science in Nursing Final Projects

Problem Identification

Residency programs for newly licensed registered nurses (NLRNs) have become an integral part of the new nurse’s transition to professional practice, improving resilience and retention of the NLRN. The goal of this integrative review is to highlight concepts and components that have been successfully incorporated into NLRN residencies and provide nursing leaders with actionable guidance to incorporate into facility-based oncology nurse residencies.

Literature Search

An integrative review using Whittemore and Knafl’s approach was conducted in accordance with principles of thematic analysis established by Toronto and Remington.

Data Evaluation

Eighteen records were included. As few research articles were found …

The Prospector, April 19, 2022, Utep Student Publications

The Prospector

Headline: "Into the Woods"

Examining Nurse Engagement In Antimicrobial Stewardship At Long-Term Care Facilities, Mosam S. Patel, Kathryn L. Dambrino, Olivia Bahemuka, David Phillippi

DNP Projects

Background: The World Health Organization stated that antimicrobial resistance is one of the top 10 threats to global health. To combat antimicrobial resistance, antimicrobial stewardship (AMS) programs were developed. Efforts to engage nurses in stewardship efforts have been limited. Bedside nurses are in an optimal position to help decrease antimicrobial use, which is especially relevant in long-term care facilities where up to 75% of antibiotic use is deemed unnecessary or inappropriate. The purpose of this Doctor of Nursing Practice scholarly project was to examine factors that influence nurse engagement in AMS at long-term care facilities in Tennessee. Methods: A …

Interprofessional Socialization Of Nursing Students After Participating In Interdisciplinary Rounds In An Intensive Care Unit, Ashlyn S. Upshaw

DNP Projects

Background: Nursing engagement in interprofessional collaboration leads to safe and quality healthcare for patients. In order to effectively engage in interprofessional collaboration, nursing students must socialize among healthcare providers from various disciplines. Purpose: The purpose of this project was to examine pre-licensure nursing students’ beliefs and attitudes towards interprofessional socialization and collaboration following their participation in interdisciplinary rounds in an intensive care unit (ICU) setting. Methods: A mixed-methods, cross-sectional design was used to collect data from undergraduate nursing students at a private university. Following an ICU clinical rotation, participants completed the Interprofessional Socialization and Valuing Survey-21 (ISVS-21) …

Effects Of Interdisciplinary Instruction On Students' Connection Of Knowledge Across Learning Domains, Karley Becker

Honors Projects

This research examines the use of interdisciplinary instruction in the early education classroom and how it impacts students' connection of knowledge across learning domains. This study looks specifically at a second-grade classroom in a midwestern state. The primary learning domains of social studies, science, mathematics, and language arts were focused on. The study is broken up into two phases: observation and implementation. Prior to the observation phase, a four-part interdisciplinary lesson plan on dinosaurs was created, including transition activities, vocabulary, state standards, and activities. After the creation of the lesson plans, the observation phase took place in which a typical …

Plant Wise, Sophia Llamas

Honors Projects

Conceptually, Plant Wise is the key to bridging the gap between preconceived ideas about vegan and vegetarianism and successfully integrating plant-based foods into your everyday life. Physically, Plant Wise is a self-educational, interactive booklet chock-full of activities intended for users to complete at their own pace. Inside this 56-page booklet, there are recipes, doodling spaces, weekly check sheets, activities to do with friends and family, challenges, and so much more. Plant Wise utilizes these activities and journaling opportunities throughout as a self-reflective vehicle to give users an experience to reflect on, which aids in the retention of what’s been learned …