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Evolving Landscape Of Respiratory Infections And Amr In The Uae: A 12-Year Nationwide Study Of Regional Burden, Epidemiologic Trends And Policy Implications, Madikay Senghore, Jens Thomsen, Najiba M. Abdulrazzaq, Wei Chen, Eveline Kaambo, Stefan Weber, Fouzia Jabeen, Godfred Antony Menezes, Carole Ayoub Moubareck, Dean B. Everett, Abiola Senok

All Works

Objectives This study characterizes the epidemiological trends and resistance profiles of respiratory tract infections (RTIs) in the United Arab Emirates (UAE) from 2010 to 2022, aiming to inform national control strategies. Method We conducted a retrospective observational study of RTI cases across 345 UAE healthcare settings using data from the national surveillance network. Pathogen identification and resistance profiling were performed using advanced diagnostics and standardized antimicrobial susceptibility testing, in accordance with Clinical and Laboratory Standards Institute (CLSI) guidelines. Results Lower respiratory tract infections (LRI) comprised most cases (73.1%; n = 100,856), including 6416 due to Mycobacterium tuberculosis , while upper …

Madwoman Makings: The Modern Girl As An Object Of Fear And Fascination In Unno Jūza’S "Mrs. Hirumi's Refrigeration Bag", Eliza Joy Mortimer

University Honors Theses

This thesis argues that Unno Jūza's 1937 short story "Mrs. Hirumi's Refrigeration Bag" uses the sensational tropes of deviant detective fiction to both stage and interrogate interwar Japanese anxieties around gender, science, and modernity. Focusing on the figure of Mrs. Hirumi—a scientifically empowered and sexually assertive female plastic surgeon who dismembers and cryogenically preserves her husband—the author reads her as a radical iteration of the Japanese Modern Girl character. By drawing on scholarship on deviant detective fiction, imperial modernity, and Kazue Harada's concept of (re)productivity, this thesis demonstrates how the short story both reproduces misogynistic criminological discourse and unsettles heteronormative …

Business Capstone Review: An Analysis Of A Local School Foundation, Emily Carlile

University Honors Theses

This capstone review thesis analyzes a school foundation in the Portland Metro Area. The capstone project was designed to conduct research to support the local school foundation, specifically the 18-35 demographic, and to increase overall funding. The project required navigating a compressed ten week timeline and coordinating a large, eleven member team to meet our client’s complex expectations. Beyond our hurdles with research, we managed multiple clients' expectations during the presentation, which were not part of the original consulting process. To maintain the project workload, we communicated with the client through a weekly email, four presentations, and a final recommendation …

Understanding The Experiences And Visibility Of Asexual People And Guiding Policy To Effectively Protect Asexuality, Lizzie Stravens

University Honors Theses

Asexuality is sexual orientation defined by those who experience little to no sexual attraction. Despite asexuality being as common as red headedness or left handedness, it has been severely overlooked in research and conversations. Because many people are not aware of the existence of asexuality, it has not been directly attacked by anti-queer campaigns. Still, there have been some recent shifts in this dynamic as asexuality becomes more visible. I conducted a linear regression on the 2022 Ace Community Survey results. I analyzed the effect of theoretically important variables on the outness of asexual respondents. Results indicated an importance on …

Effect Of Dental Treatments On Reduction Of Preterm Birth: A Systematic Review And Meta-Analysis, Camille Thomas, Shakil Ahmed, Vincenzo Berghella, Romina Brignardello-Petersen, Mohamed El-Rabbany, Catherine Devion, Stefania Ronzoni

Department of Obstetrics and Gynecology Faculty Papers

OBJECTIVE: Periodontal disease is associated with increased risk of preterm birth. Effective management during pregnancy may reduce preterm birth, though clinical trial evidence has been inconsistent. This study aimed to assess whether treating dental disease during pregnancy reduces preterm birth.

DATA SOURCES: A systematic search was performed of EMBASE, MEDLINE, PubMed, Cochrane Library, and trial registries up to December 2023 and re-run in January 2025.

STUDY ELIGIBILITY CRITERIA: Randomized controlled trials (RCTs) enrolling pregnant persons with any dental disease randomized to receive dental treatment vs no treatment were included. No language restriction was applied.

STUDY APPRAISAL AND SYNTHESIS METHODS: Data …

Differences In Student Basic Need Satisfaction Across University Community Service Offerings In Vietnam, Myles Lynch, Nguyen Lam Phuong, Duong Ngoc Anh, Huy Ngoc Vu, Hoang Quang Thang

Journal of Youth Development

In 2018, the Vietnam Ministry of Education and Training (MOET) made experiential learning a mandatory component of general education in an effort to enhance student skills pertaining to career and professional success. Community service, as a form of experiential learning, can enable individuals to apply knowledge and skills to address societal challenges beyond classroom settings. The availability and effectiveness of structured community service-learning programs vary across Vietnamese universities. Using Basic Needs Theory (autonomy, competence, relatedness), a sub-theory of Self-Determination Theory, this study examined differences in Vietnamese student need satisfaction based on availability of community service courses, providing insights into program …

Evaluating Youth Programs With Intention: Integrating Developmental Research For A Youth-Centered Approach, Brittany Hite, Tiffany Berry, Evangelia Theodorou, Michelle Sloper

Journal of Youth Development

Conducting applied research or program evaluations in youth settings requires a unique combination of expertise. Although evaluation approaches provide general guidance on how to conduct high-quality evaluations, they rarely provide specific guidance on how to engage in evaluation with organizations serving youth. Fortunately, the field of youth development provides extensive information about how youth develop, facilitators of and influences on youth development, and important considerations for collecting data from this population. This paper provides an approach to evaluation that integrates youth development research. By integrating this literature into their evaluation practice, the authors identified two underlying principles (contextual sensitivity and …

Youth Development Opportunities Among Sexual/Gender Minoritized Youth: Who Is Left Out?, Amy L. Gower Ph.D., Ben Parchem, G. Nic Rider, Hana-May Eadeh, Ryan Watson, Samantha E. Lawrence, Stephen Russell, De'shay Thomas, Marla E. Eisenberg

Journal of Youth Development

Youth development opportunities promote health and wellbeing across adolescence. However, scholars have increasingly questioned whether these programs are relevant to and meet the needs of youth with minoritized identities. Using an intersectionality lens, 2022 Minnesota Student Survey data from 8th, 9th, and 11th graders who indicated a minoritized sexual and/or gender identity (N=24,400) were analyzed using exhaustive Chi-square automatic interaction detection to understand how youth’s racial, ethnic, sexual, and gender identities and grade contributed to engagement in youth development opportunities. Mean youth development opportunity scores were lowest among youth with multiple minoritized identities, particularly transgender and gender diverse youth of …

Implementation And Outcomes Of The Men Of Strength (Most) Club, Marni Kan, Ashley N. Lowe, Jason Williams, Cheryl Roberts, Katherine Suellentrop, Nichole M. Scaglione

Journal of Youth Development

Evidence is lacking for positive youth development programs for boys that use gender transformative approaches and promote peer leadership to prevent sexual violence and teen dating violence. This study aimed to address gaps in violence prevention research and youth development practice by evaluating implementation and outcomes of the Men of Strength (MOST) Club. Sixteen high schools were randomized to MOST Club or a control condition and 60 boys from nine of the schools completed baseline and follow-up surveys. Trained program facilitators completed logs after each session. Although the COVID-19 pandemic interfered with both program implementation and data collection, MOST Clubs …

Boosting Agriculture Career Readiness In Stem Through A Virtual Symposium, Suzanna R. Windon, Hosung You, Christina Grozinger, Natalie Boyle, Hongmei Li-Byarlay, Torrence A. Gill, Simon Zebelo

Journal of Youth Development

This study evaluated a recorded virtual career symposium aimed at enhancing STEM in Agriculture and graduate education readiness among students from Minority-Serving Institutions.The evaluation focused on changes in participants’ perceived readiness for STEM careers and graduate education, the relationship between readiness and demographic factors, and participants’ overall experience with the event. Featuring presentations from faculty and alumni, the symposium highlighted career pathways in agriculture and entomology, essential skills, and graduate education opportunities. Participants from five institutions were invited to view the recorded sessions and complete an online survey. Of the 56 responses received, 41 were analyzed. Results indicated that most …

To Employment And Beyond: Life Skills Development Through A Private-Nonprofit Partnership, Spencer Dudley, Victoria Haley

Journal of Youth Development

The transition to employment is a pivotal step for youth and young adults. A successful shift to the workforce can support financial independence and open pathways toward further learning and personal growth. Employers increasingly prioritize life skills over complex or technical skills in the current labor market. However, opportunities to develop these skills are not equitably distributed. Life skills training programs within a positive youth development framework show promise in affording historically marginalized youth populations opportunities to identify and develop these skills, yet research on youth experiences in such programs remains limited. This qualitative study draws on focus groups and …

Growing Mathletes: Integrating Growth Mindset, Math, And Sports To Support Youth Learning, Sanlyn Buxner, Erin Turner, Seneca B. Miller, Christina Baze, Ricardo Valerdi

Journal of Youth Development

Through Growing Mathletes, we developed and field-tested informal education activities designed to teach math within the context of baseball in a way that supports youth in developing a growth mindset. We present our development strategy and discuss our implementation with third through eighth graders at five informal learning sites across the United States. Assessment of program success included pre- and post-program surveys and post-program interviews with youth from all five informal education settings. Our findings revealed our strategy to integrate growth mindset concepts with math and baseball lessons led to positive outcomes related to youth mindset and confidence. We present …

Positive Youth Development And Connection With Nature Through Urban Agriculture, Casey Ortbahn, Marijke Hecht, Kristi Lekies

Journal of Youth Development

Youth urban agriculture programs connect youth with nature and support positive youth development. In this qualitative study, we use photovoice to amplify youth voices and explore 16 high school youths’ perceptions of how participation in a youth gardening program supported their confidence, connection, and sense of belonging. Using qualitative thematic analysis of photos, posters, and interviews, we identify several program processes that supported confidence and belonging, including meaningful relationships with peers and adults, connections with nature, and relationships with more-than-human beings. Our analysis reveals that nature is an important context for youth development and that nature is also more than …

Impulsivity In Nrcam Ko Mice Is Reduced By Nmdar Antagonist Mk-801 But Not By Ampar Antagonist Cnqx, Mona Buhusi, Catalin V. Buhusi

Psychology Faculty Publications

The neuronal cell adhesion molecule NrCAM is widely expressed in the nervous system across the lifespan and has important physiological functions in the development of neuronal circuits through axonal growth and guidance and formation and maintenance of synapses in the cortex. NrCAM gene polymorphisms are associated with vulnerability to neuropsychiatric disorders such as schizophrenia, as well as vulnerability to substance use disorders. We investigated the effects of acute and chronic stress and the effects of systemic administration of AMPAR antagonist CNQX and NMDAR antagonist MK-801 on delay discounting in male NrCAM knockout (KO) mice and their wild-type littermate controls (WT). …

Complicit Nullification: The Illegitimate (Abrogation) Of School Religious Liberty Precedent, Amanda Harmon Cooley

Cardozo Law Review

Louisiana has enacted legislation that mandates the display of the Ten Commandments in every public school classroom. This statutory mandate directly contradicts the Supreme Court’s extant precedent in Stone v. Graham. Legislators in Texas, North Dakota, South Dakota, Oklahoma, Tennessee, and Kentucky have also indicated plans to introduce similar unconstitutional legislation, defying the Supreme Court’s interpretations of the First Amendment’s Religion Clauses. Similarly, Texas and Florida now permit public school chaplains or Bible-based public school curricula, which violates the Court’s longstanding prohibitions on such actions, as established in its 1948 ruling in Illinois ex rel. McCollum v. Board of Education …

Can’T Get Work Off My Mind: The Effect Of Nonwork Goal Reflection On After-Work Rumination And Well-Being, Trevor A. Foulk, Min-Hsuan Tu, Michael Schaerer, Amber Johnson

Research Collection Lee Kong Chian School Of Business

Many employees lament that their inability to stop ruminating about work during nonwork time is one of their most significant work-related challenges, yet limited research has articulated actionable strategies to address this issue on a day-to-day basis. Integrating goal shielding theory with rumination theory, our model introduces nonwork goal reflection as a deliberate behavioral intervention employees can engage in to curtail work-related rumination, in a way that facilitates well-being during nonwork time. Specifically, we argue that engaging in nonwork goal reflection—where employees intentionally reflect on nonwork goals to be completed during their nonwork time—can curtail work-related rumination and is associated …

Mermaids In Pools: Ex-Situ Conservation As A Cornerstone For Sirenian Management Worldwide, D. N. Castelblanco-Martínez, E. A. Ramos, A. Alvarez-Alemán, F. L. N. Attademo, L. J. Cabrias-Contreras, D. Caicedo-Herrera, S. S. Landeo-Yauri, F. O. Luna, Miriam Marmontel, J. Sanchez, Carlos J. Silva, Vera Da Silva, Diogo Londero Da Silva, A. A. Mignucci-Giannoni

Faculty Publications

No abstract provided.

A Manifesto For Plant Science Education, Elizabeth Alvey, Andrea Paterlini, Mary E. Williams, Mia E. Cerfonteyn, Samantha Dobbie, Steven Dodsworth, Sonja D. Dunbar, Lauren R. Headland, Anastasia Kolesnikova, Pankaj Kumar, Silvia Manrique, Catherine Mansfield, Sebastian Stroud, Shannon Woodhouse, Hailey Ashton, Yoselin Benitez-Alfonso, Emily Breeze, Kelsey J.R.P. Byers, Chana P. Chetariya, Beth C. Dyson, Alec Forsyth, Beatriz Gonçalves, Camila Gonzalez, Daniel M. Jenkins, Joanna Kacprzyk, Kirsten Knox, George R. Littlejohn, Sara Lopez-Gomollon, Enrique López-Juez, Claudia Martinho

School of Biological and Marine Sciences

Societal Impact Statement: Plants provide oxygen, food, shelter, medicines and environmental services, without which human society could not exist. Tackling pressing and global challenges requires well-trained plant scientists and plant-aware individuals. This manifesto provides a practical evidence-based vision to strengthen plant science education, focused on five strategic priorities. It is relevant to all stakeholders within plant science and beyond: from frontline educators to institutional leaders; from commercial or charitable professionals to entrepreneurs and donors; from individual community members to their legislative representatives. Strengthening plant science education demands concrete actions from all stakeholders, ultimately to the benefit of us all. Summary: …

Trust Transference And Cognitive Affective Trust Dichotomy In Tiktok Short-Form Videos: The Moderating Role Of Source Homophily, Rajat Subhra Chatterjee, Mosharrof Hosen, Irfan Hameed, Hafiz Mudassir Rehman

Plymouth Business School

This study explores the under-researched area of cognitive-affective trust transference within the context of short-form videos (SFV) on the TikTok platform. It also provides new insights into the impact of source homophily that arises from viewing SFV. The study incorporates trust transfer theory into the Stimulus-Organism-Response (SOR) model perspective to examine trust transference. Data were gathered from 411 online users in Malaysia using a purposive sampling technique. Partial least squares structural equation modeling has been used to analyze the data via SmartPLS. The findings suggest that video characteristics, platform trust, and source credibility of SFVs on TikTok affect affective trust …

Rounding Styles On Inpatient Infectious Disease Consult Services: Impact On Education And Patient-Care Delivery, Melanie Kiener, Vanessa Ku, Prathit A Kulkarni

Faculty, Staff and Students Publications

Inpatient infectious disease (ID) consult services have recently been experiencing increased patient volumes due to a variety of factors, including higher patient complexity, increased patient turnover, growing rates of antimicrobial resistant infections, population aging, and ID outbreaks. As a result, increased time and resources have been required to continue to deliver high-quality medical care to patients. At academic teaching hospitals, providing patient care in the context of increased volumes must be balanced with the educational mission for trainees. Rounding is a central component of ID clinical work which brings together patient care and education. In this narrative review, we aim …

Validation And Longitudinal Trajectory Analysis Of An Ai-Based Ecg Model For Aortic Stenosis: From Community Screening To Pre-Ta\Vr Risk Stratification, Matthew W Segar, Kaleb D Lambeth, Alexander Postalian, Stephanie Coulter, Jasen Gilge, Naveed Razvi, Mohammad Saeed, Robert D Paisley, Ambarish Pandey, Mehdi Razavi

Faculty, Staff and Students Publications

Aims: Early aortic stenosis (AS) detection remains challenging, with many patients presenting late when left ventricular dysfunction may be irreversible. We evaluated whether longitudinal AI-enhanced ECG patterns can predict outcomes years before intervention and assessed the community screening potential of the AK-AVS model.

Methods and results: We conducted two complementary analyses: (1) community validation of the AK-AVS model in 3632 cardiovascular disease-free ARIC participants, and (2) longitudinal trajectory analysis of 7860 ECGs from 2040 TAVR recipients collected up to 10 years pre-procedure. Unsupervised clustering identified distinct AK-AVS trajectories, with mortality associations assessed using Cox regression and net reclassification improvement. In …

Comparison Of Opioid Utilization In Older Adults With Rheumatoid Arthritis Before And After Initiating Biological Or Targeted Synthetic Disease-Modifying Antirheumatic Drugs, Yinan Huang, Shadi Bazzazzadehgan, Liang-Yuan Lin, Omkar Ghodke, Sebastian Bruera, Kaustuv Bhattacharya, Sujith Ramachandran, John P Bentley, Sandeep K Agarwal, Yi Yang

Faculty, Staff and Students Publications

Introduction: Opioid use is common in rheumatoid arthritis (RA) for pain management; however, evidence of opioid-associated adverse events is increasing. While biological (b) or targeted synthetic (ts) disease-modifying antirheumatic drugs (DMARDs) improve functional outcomes such as pain, little is known about their impact on opioid utilization patterns. This study investigated opioid utilization before and after b/tsDMARD initiation and assessed effect modification by sex.

Methods: Using 5% Medicare claims data from 2012 to 2020, this cohort study included older adults (≥ 65 years) with RA who initiated b/tsDMARDs (first prescription = index date), and had continuous Medicare Parts A, B, and …

Sex Differences In Hospitalizations In The 6 Months Before A Diagnosis Of Transthyretin Amyloid Cardiomyopathy, Chun Shing Kwok, Adnan I Qureshi, Richard P Steeds, Gregg C Fonarow, Biykem Bozkurt, Marianna Fontana, Julian D Gillmore, William E Moody

Faculty, Staff and Students Publications

Background: The influence of sex on the extent of missed opportunities for early diagnosis of transthyretin amyloid cardiomyopathy (ATTR-CM) has not been characterized.

Objectives: The objective of the study was to determine the rate and causes of hospitalization preceding the index admission with ATTR-CM, stratifying analyses according to sex.

Methods: We conducted a retrospective cohort study of the National Readmissions Database to evaluate the 6-month hospitalizations preceding an index admission with a diagnosis of ATTR-CM.

Results: Between 2018 and 2020, there were 10,975 patients hospitalized with ATTR-CM of whom 4,545 (41.1%) had 1 or more hospital admission within the preceding …

Nasopharyngeal Microbiome-Epigenome-Wide Association Analysis In Infants With Severe Bronchiolitis, Ryohei Shibata, Yijun Li, Anat Yaskolka Meir, Sara Javornik Cregeen, Matthew Clayton Ross, Janice A Espinola, Ashley F Sullivan, Liming Liang, Kohei Hasegawa, Carlos A Camargo, Zhaozhong Zhu

Faculty, Staff and Students Publications

Background: Bronchiolitis exposes infants to both acute burdens (e.g., hospitalization in cases of severe bronchiolitis) and increased risks for chronic respiratory sequelae (e.g., asthma). In severe bronchiolitis, recent evidence suggests distinct pathobiological roles of microbiota (e.g., viruses, bacteria) and host responses influenced by genetic and epigenetic factors. However, the relationship of airway microbiota with host DNA methylation (DNAm) in infants with severe bronchiolitis remains unknown.

Methods: In a multi-center prospective cohort of 504 multi-ethnic infants with severe bronchiolitis (age < 1 year), using nasopharyngeal microbiome (exposure) and blood DNAm (outcome, Infinium MethylationEPIC BeadChip, Illumina) data within 24 h of the hospitalization, we conducted microbiome-epigenome-wide association studies (mbEWAS). We examined microbiota-associated differentially methylated CpGs (mbDMCs, false discovery rate [FDR] < 0.05), regions (mbDMRs, FDR < 0.05), and DNAm age acceleration. We also determined the associations of DNAm age acceleration with asthma development by age 6 years. Furthermore, we focused on asthma-related pathogenic bacteria-Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae-for functional analyses by examining serum mbDMR-related proteins (Proseek Multiplex, Olink) and their enriched pathways (FDR < 0.10).

Results: Across 23 common taxa-observed at least in 25% of the infants, we identified 1 mbDMC (S. pneumoniae, cg16594639, chr20: 39528675) …

Histone Demethylase Jmjd1a Protects Mice From Enteric Bacterial Infection By Upregulating Ccl8 Expression To Recruit Macrophages And Cd4+ T Cells, Guifang Lin, Lichun Yang, Shuyan Jiang, Yong Zhang, Ping Luo, Weihua Li, Jianming Xu, Gongpeng Xiong, Chundong Yu, Wenbo Chen

Faculty, Staff and Students Publications

Jumonji domain-containing 1A (JMJD1A, also known as KDM3A) is a histone demethylase that specifically demethylates H3K9me1/2 to enhance gene expression. The roles of JMJD1A in many physiological and pathological processes have been revealed. However, it is unclear whether JMJD1A is involved in host defense against enteric pathogen infection. In this study, we found that enteric infection with C. rodentium induced JMJD1A expression in colonic epithelial cells at the transcriptional level partly mediated by IRF1. After C. rodentium infection, JMJD1A-/- mice exhibited increased mortality, colonic injury, and C. rodentium load and systemic spread, suggesting that JMJD1A protects host against C. rodentium …

Online Tutorial On Survival Analysis For Biomarker Discovery, Jaka Kokošar, Ela Praznik, Martin Špendl, Nancy P Moreno, Alana Newell, Gad Shaulsky, Blaž Zupan

Faculty, Staff and Students Publications

In biomedicine, survival analysis addresses time-to-event data to study outcomes like patient survival and treatment response, and supports biomarker discovery. Yet, teaching this analysis is often hindered by mathematical and programming barriers. We present a structured, hands-on tutorial that goes beyond a typical online guide-offering integrated video lectures, literature, quizzes, and practical exercises. Built around Orange Data Mining, an open and free no-code visual analytics platform, the tutorial covers key concepts such as censoring, Kaplan-Meier curves, group comparisons, and biomarker discovery through real-world datasets. Organized in four pedagogical units, it progresses from basic survival data analysis to gene and gene-set …

Comparison Of Variant Callers Using 60 532 Multi-Ancestry Whole Genome Sequences, Hufeng Zhou, Zilin Li, Derek Shyr, Xihao Li, Haoyu Yang, Rounak Dey, Yushi Tang, Robert Maier, Eric Boerwinkle, Steve Buyske, Mark Daly, Adam Felsenfeld, Richard A Gibbs, Namrata Gupta, Ira M Hall, Tara Matise, Ginger A Metcalf, Albert Smith, Catherine Reeves, Heidi J Sofia, Nathan O Stitziel, Michael C Zody, Nhgri Genome Sequencing Program (Gsp) Consortium, Benjamin Neale, Xihong Lin

Faculty, Staff and Students Publications

Whole genome sequencing (WGS) studies play a pivotal role in studying the genetic underpinnings of human diseases and traits. High quality and reproducible variant calling is the cornerstone for the success of downstream analyses, including WGS association studies and polygenic risk prediction. This paper compares the data quality, performance, and concordance of two widely used WGS variant callers, the Genome Analysis Toolkit (GATK) and Variant Tool set that discovers short variants (VT), using 60 532 multi-ancestry whole genomes sequenced by the Centers for Common Disease Genomics (CCDGs) of the NHGRI Genome Sequencing Program. Our findings show that both QCed GATK …

Segmental And Multifocal Isolated Dystonias: Similarities And Differences, Hyder A Jinnah, Vittorio Velucci, Daniele Belvisi, Gamze Kilic-Berkmen, Joel S Perlmutter, Laura J Wright, Christine Klein, Jeanne S Feuerstein, Steven Bellows, Joseph Jankovic, Cynthia Comella, Richard L Barbano, Aparna Wagle Shukla, Stephen G Reich, Mark S Ledoux, Alberto J Espay, Kevin R Duque, Florence C F Chang, Victor S C Fung, Sarah Pirio-Richardson, Carmen Terranova, Emile S Moukheiber, Sarah Idrissi, Barbara Vitucci, Susan H Fox, Samuel Frank, Natividad Stover, Brian D Berman, Rachel Saunders-Pullman, William G Ondo, Christopher L Groth, Marcello Esposito, Laura Avanzino, Francesco Bono, Roberto Erro, Marcello Mario Mascia, Antonella Muroni, Alfredo Berardelli, Giovanni Defazio

Faculty, Staff and Students Publications

Background: Whether the traditional distinction between segmental and multifocal dystonia is clinically or scientifically useful remains unclear.

Objective: To evaluate whether idiopathic isolated adult-onset segmental and multifocal dystonia can be differentiated based on clinical features other than the contiguity of affected body regions.

Methods: We compared data on segmental and multifocal dystonia from two large dystonia databases established in the USA and Italy that used similar criteria for patient recruitment and assessment.

Results: Compared to segmental dystonia, multifocal dystonia was characterized by a higher proportion of men, a younger age at dystonia onset, a greater frequency of upper limb dystonia, …

Impulsivity In Cerebellar Ataxia: An Online, Multidimensional Assessment, Brooke Chasalow, Yakov Flaumenhaft, Yael De Picciotto, Chi-Ying R Lin, Leila Montaser-Kouhsari, William Saban

Faculty, Staff and Students Publications

While considered a motor control structure, the cerebellum contributes to non-motor functions, including impulsivity. However, whether it contributes to impulsivity in a domain-specific manner remains unknown. Studies on cerebellar ataxia (CA), a common model for cerebellar dysfunction, typically have small sample sizes, limiting robustness. In a multicenter cross-sectional study, we investigated the cerebellum's role in various forms of impulsivity by comparing large cohorts of CA to age- and education-matched neurotypical healthy (NH) controls. Additionally, to examine the ability to identify individuals with CA using impulsivity features alone, we developed supervised machine learning (ML) models. In experiment 1 (CA = 140, …

Responsive Neurostimulation In Children, Adolescents, And Young Adults-Longitudinal Effectiveness And Safety, Steven T Lee, Shital Patel, Cemal Karakas, Kimberly Houck, Cristina Trandafir, Matthew J Mcginley, Deepankar Mohanty, James J Riviello, Howard L Weiner, Daniel Curry, Irfan Ali

Faculty, Staff and Students Publications

Drug-resistant epilepsy (DRE) remains challenging to treat, and seizure control often fluctuates over time. Responsive neurostimulation (RNS) is increasingly used in pediatric and young adult populations, yet long-term effectiveness and safety data are limited. We evaluated longitudinal seizure control trajectories and safety of RNS in children, adolescents, and young adults treated at our center. Seizure frequency was assessed at approximately 6-month intervals from serial follow-up visits through the most recent follow-up, with each sampled visit categorized by ≥ 50 % (all-responder, AR) or ≥90 % (super-responder, SR) seizure reduction. We examined the persistence and durability of seizure control and used …