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Icc Agenda 3-3-26, Angela Brock

Individual Course Committee (ICC)

No abstract provided.

Pharmacologic And Oncohistone Inhibition Of Setd2 Converge On Genomic Instability, Alyssa T Paparella, Ashley G Boice, In Young Park, Rajkishor Nishad, Durga Tripathi, Seth A Nelson, Edward W Pietryk, H Josh Jang, Ian J Frew, W Kimryn Rathmell, Frank M Mason, Cristian Coarfa, Ruhee Dere, Cheryl Lyn Walker

Faculty, Staff and Students Publications

Background/objectives: SETD2 is a dual-function methyltransferase important for methylation of histone H3 at lysine 36 and α-tubulin in spindle microtubules. Genetic inactivation of SETD2 during oncogenesis drives loss of H3K36me3, genomic instability, and cancer progression. This study asked if disruption of genomic stability was a canonical feature of SETD2 inactivation via different pathways.

Methods: We evaluated the impact of EPZ-719, a pharmacologic SETD2 inhibitor, and an H3.3K36M mutant histone ("oncohistone") that binds and sequesters SETD2, on methylation activity and genomic stability in human cell lines. SETD2 activity was measured using in vitro methylation assays, H3K36me3 loss confirmed by Western analysis, …

Ten Years Real-World Experience With Sacubitril/Valsartan In Patients With Heart Failure With Reduced Ejection Fraction, Gianluigi Savarese, Christian Basile, Alexandre Mebazaa, Antoni Bayes-Genis, Seok Min Kang, Byung-Su Yoo, Carlos Eid, Biykem Bozkurt, Javed Butler

Faculty, Staff and Students Publications

Introduction: Sacubitril/valsartan (Sac/Val) represents a cornerstone of heart failure (HF) with reduced ejection fraction (HFrEF) management. This systematic review provides a comprehensive overview of real-world evidence (RWE) regarding the implementation, clinical effectiveness, and safety of Sac/Val in patients with HFrEF.

Methods: A systematic literature search of PubMed was conducted through March 2024 following PRISMA guidelines.

Results: The review included 45 manuscripts from 30 different studies, primarily from Europe (44%) and the US (30%). RWE confirmed that Sac/Val was associated with a lower risk of cardiovascular mortality (10%-16%), HF hospitalization (10%-38%), and all-cause mortality (10%-25%). Sac/Val was significantly associated with cardiac …

Circulating Ketone Bodies And Incident Cardiovascular Outcomes And Mortality: Insights From The Uk Biobank, Parag Anilkumar Chevli, Saeid Mirzai, Richard Kazibwe, Jeff Kingsley, Alexis C Wood, Joseph Yeboah, Leandro Slipczuk, Anurag Mehta, Harpreet S Bhatia, Ambarish Pandey, Michael D Shapiro

Children’s Nutrition Research Center Staff Publications

Background: Ketone bodies (KB) are endogenous energy sources synthesized by the liver in response to metabolic stress. Their associations with atherosclerotic cardiovascular disease (ASCVD), heart failure (HF), and mortality and their potential beneficial or harmful effects have yet to be determined. This study aimed to examine the association between KB and incident cardiovascular outcomes and mortality in a large general population cohort free from ASCVD and HF at baseline.

Methods: This analysis included 90 987 participants (mean age 56.4 ± 8.1 years; 54.7% women) from the UK Biobank without prevalent ASCVD or HF. KB were measured by nuclear magnetic resonance …

Pd-L1 Positivity Predicts A Unique Hyperaggressive Tumor Group Within Meng C Meningiomas, Vijay Nitturi, Shervin Hosseingholi Nouri, Collin English, Hsiang-Chih Lu, Elizabeth Ledbetter, Diego Rojas, Sean Lau, Malcolm Mcdonald, Jacob J Mandel, Abdul Basit Khan, Arif O Harmanci, Akdes S Harmanci, Tiemo Klisch, Akash J Patel

Duncan NRI Faculty and Staff Publications

Molecular profiling has identified 3 groups of meningiomas, with MenG C tumors exhibiting the vast majority of recurrences. Efforts to find effective treatments for recurrent meningiomas have remained elusive. Higher WHO-grade meningiomas have exhibited greater Programmed Death Ligand 1 (PD-L1) expression through various methods, but the prognostic value of PD-L1 expression has not been described in the context of molecular profiling. Additionally, trials investigating PD-1/PD-L1-targeted immunotherapies have produced disappointing results. Here, we find that PD-L1 positivity, while prevalent in MenG C tumors, does not predict recurrence in the benign MenG A and B tumors. PD-L1 positivity also occurs independently of …

Striving To Become A Dean Of Faculty Affairs And Development, Beatriz Tapia, Guadalupe Federico-Martinez

School of Medicine Publications

Academic medicine allows you to grow in your field of expertise and interest. Yet, the guidance you receive will provide you with the path toward successful professorial promotion. As a dean of faculty affairs and development, there is no greater pleasure than serving as a guide for faculty across their life cycle from recruitment to retirement and everything in between. In this chapter, you will find information regarding the dean of faculty affairs and development role. Depending on the maturity of your institution, you will need to define who is intended for you to serve and where the greatest needs …

Integrated Multi-Omic Analysis Reveals Novel Subtype-Specific Regulatory Interactions In Pediatric B-Cell Acute Lymphoblastic Leukemia., Irina Pushel, Zachary S. Clark, Lisa A. Lansdon, Byunggil Yoo, Michaella J. Rekowski, Nicole Wood, Michael P. Washburn, Midhat S. Farooqi

Manuscripts, Articles, Book Chapters and Other Papers

Background/Objectives: Molecular subtyping of pediatric B-cell acute lymphoblastic leukemia (B-ALL) has improved patient outcomes through stratification and selection of targeted therapies. Despite extensive genomic and transcriptomic profiling of this cancer, few studies to date have characterized the proteomic landscape, although proteins are the direct targets of many therapeutic agents. Methods: In this study, we demonstrate the utility of multi-omic integration of global transcriptomic, proteomic, and phosphoproteomic profiles of samples from patients diagnosed with either of two B-ALL subtypes-Ph-like (BCR::ABL1-like) and ETV6::RUNX1. Through individual and multi-omic analysis, we recapitulate known transcriptomic findings and identify novel subtype-specific …

Rti Restoration Technologies Inc V. International Painters And Allied Trades Industry

2026 Decisions

USDC for the District of New Jersey

Clinical Validation Of Perfusion Imaging With Pulmonary Function Test Data Using Voronoi-Based Discretization, Jorge Cisneros, Caleb J. Herrera, Yi-Kuan Liu, Lisa V. Du, Yevgeniy Vinogradskiy, Richard Castillo, Girish Nair, Edward Castillo

Department of Medicine Faculty Papers

Objective.Accurate lung function assessment is essential for diagnosing and managing diseases like chronic obstructive pulmonary disorder, pulmonary emboli, and lung cancer. Single-photon emission computed tomography (SPECT) provides valuable 3D functional imaging of ventilation and perfusion, but is limited by low spatial resolution, availability, additional radiation, and cost. Alternative methods, including CT-based perfusion (CT-P) and deep learning models, require large datasets to validate results that are often scarce. Pulmonary function tests (PFTs) offer rapid and noninvasive global lung function measures and are clinically widely used. While ventilation correlates well with PFTs, perfusion imaging presents challenges due to complex blood flow and …

Comparative Antibacterial Efficacy Of Povidone-Iodine, Citric Acid, And Starch: A Study Of Combined Activity And Interference Effects Against Clinically Relevant Bacteria, Falah Hasan Obayes Al-Khikani, Mustafa Mutar Trrad, Ali Abedulameer Alhusayni

AUIQ Complementary Biological System

Povidone-iodine and citric acid are widely used antimicrobial agents. However, data on their comparative efficacy and the functional outcomes of their combination, particularly regarding the influence of common excipients like starch, is limited. Understanding these interactions is crucial for optimizing antiseptic formulations. This study aimed to evaluate and compare the antibacterial activity of povidone-iodine, citric acid (5% and 20%), and starch (5% and 20%), both individually and in combination, against clinical isolates of Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. The antibacterial activity of the agents was assessed using an agar well diffusion assay. Mean inhibition zone …

Self-Aware Quantum-Inspired Routing Framework For 6g And Quantum Networks, Haitham M. Abdelghany, Mohamed M. Ashour

Mansoura Engineering Journal

This paper introduces a quantum-hybrid-aware routing framework that incorporates the concepts of quantum computing with meta-cognitive learning to improve adaptability, reliability, and awareness in dynamic quantum networks. The proposed system accommodates a new IoT, edge computing and 6G system, where routing schemes should be flexible and robust and have cross-topology functionality. Conventional methods of quantum reinforcement learning can be characterized by a trade-off between exploration and decision stability. To cope with this, the proposed self-aware hybrid architecture is a combination of quantum-enhanced learning and a meta-cognitive awareness layer to allow autonomous agents to monitor performance and adjust routing strategies on …

Intelligent Fault Diagnosis Of Ev Induction Motors Using Multi-Sensor Ann And Explainable Ai For Sustainable Transportation, Royal Madan, Ahmed Ali Farhan Ogaili

Terra Joule Journal

Maintaining the dependability and operational continuity of electric vehicle (EV) drivetrains has become crucial as the world's shift to electrified transportation picks up speed. This is a major obstacle for sustainable mobility. Using a high-capacity Artificial Neural Network (ANN), this study presents a data-driven multi-sensor framework for advanced fault diagnosis of induction motors in EV applications. The publicly available University of Ottawa dataset that encompasses nine distinct fault categories and 180 test samples was utilized to replicate both mechanical failure modes (e.g., broken rotor bars, bearing defects, rotor misalignment) and electrical anomalies (e.g., stator winding faults, voltage imbalance) under constant …

Significance Of Relationships In Navigating Disability, Shivani Bhalla Dr

Journal of Social Theory in Art Education

I have addressed the theme of movement and momentum by referring to the importance of relationships and seeking community in navigating through the challenges of disability experiences. In this paper, I will explore how my relationships with my family members, fellow disabled artists, educators, and scholars helped me learn from my disability experiences and gave me the courage to come out as a person with disability (PWD) and explore disability as a sight of knowledge production.

Boundless Community: A Developing Disability Arts Movement, Sarah K. Benson, Khaldoun Hijazin, Alaa Qattam, Suha Khuffash

Journal of Social Theory in Art Education

Over several years, individual organizations in Jordan have been focused on increasing the participation of individuals with disabilities in the arts. Increasing inclusion can provide a powerful tool to create visibility, amplify marginalized voices and disrupt normative narratives. However, these isolated efforts had a limited impact until a cohesive effort borne by a burgeoning community of practice led to the first Amman Arts and Disability Summit. Bringing together youth, artists and gallery owners, the movement leaders are using models of social learning and communities of practice to create a more inclusive arts community. The movement stands on the precipice of …

Segi Hukum Dalam Pengendalian Pencemaran Lingkungan Hidup, Soerjono Soekanto

Jurnal Hukum & Pembangunan

Abstract

Pertanggungjawaban Terhadap Delik-Delik Ekonomi, Prof. Dr. A. Zainal Abidin F., S.H>

Jurnal Hukum & Pembangunan

Abstract

Parametric Evaluation And Biomechanical Assessment Of A Curved Biodegradable Zk60 Locking Plate For Femoral Shaft Fractures Using Finite Element Analysis, Ahmad Jasim, Jenan Kashan, Aseel Abed

Engineering and Technology Journal

This study evaluates the biomechanical performance of a novel curved biodegradable ZK60 magnesium alloy locking plate for plate osteosynthesis in midshaft femoral fractures classified as AO/ASIF 32-A3 (Arbeitsgemeinschaft für Osteosynthesefragen/Association for the Study of Internal Fixation). Current metallic implants are associated with complications such as stress shielding, the need for secondary surgery, and limited support for biological healing. Biodegradable options offer promising solutions but remain insufficiently studied, especially regarding curved plate designs. This work addresses that gap by systematically assessing how plate thickness and curvature influence fracture stability. Finite element analysis (FEA) was performed under physiological loading of 700 N …

Effect Of Ag-Ptfe Nanocomposite Coating On Wettability And Antimicrobial Activity Of Orthodontic Wires, Mahmood Naser, Emad Al-Hassani, Fatima Al-Hassani

Engineering and Technology Journal

This study investigates the effect of Ag–PTFE nanocomposite coatings, prepared by radio frequency (RF) sputtering, on the surface and antimicrobial properties of orthodontic stainless steel archwires (SSW). The novelty lies in combining silver (Ag) and polytetrafluoroethylene (PTFE) nanoparticles into one coating, which has not been widely applied to orthodontics. The motivation is the need to reduce microbial adhesion and biofilm on archwires, which contribute to enamel demineralization, gingival disease, and infections. The problem addressed is the lack of coatings that can simultaneously provide enhanced surface properties, facilitate controlled silver ion release, and deliver durable antibacterial performance. Unlike literature that mainly …

Sustainable Geopolymer Concrete: Iraqi Steel Slag As A High-Performance Aggregate For Improved Strength And Durability, Riyam Jaddana, Hussein Jaber

Engineering and Technology Journal

The construction industry’s reliance on ordinary Portland cement (OPC) contributes significantly to CO₂ emissions and resource depletion. Geopolymer concrete (GPC) offers a sustainable alternative, but natural aggregates (NAs) still harm the environment. This study investigates recycled coarse steel slag aggregate (RCSA), a metallurgical byproduct, as a partial replacement (10, 20, 30, and 40% by volume) for natural coarse aggregate (NCA) in metakaolin-based GPC. The geopolymer paste was formulated with optimal molar ratios of 3.65 for SiO₂/Al₂O₃, 2.9 for sodium hydroxide/ sodium silicate, and 0.62 for water/metakaolin. Results showed that incorporating RCSA enhances both mechanical and physical properties of GPC. Optimal …

Enhancing Antibacterial Performance Of Powder Metallurgy-Fabricated Ti, Ti-15mo, And Ti-45zr Alloys Through Small Liquid Metal Gallium Additions In Biomedical Applications, Ammar Hasan, Fatimah Al‑Hasani, Emad Al‑Hassani

Engineering and Technology Journal

This study investigates the influence of small liquid metal gallium additions (1, 1.5, 2, and 2.5 wt%) on the antibacterial performance of Ti, Ti-15Mo, and Ti-45Zr alloys fabricated by the powder metallurgy method. The alloys were manufactured by sintering at 1250 °C to improve the antibacterial activity of Titanium and its alloys in biomaterial applications. X-ray diffraction (XRD) was used to identify the dominant compounds and phases after adding liquid gallium metal, and the antibacterial activity was also tested; the results indicate an increase in the Zone of inhibition of Ti, Ti-15Mo, and Ti-45Zr with increasing gallium/Ga content, where the …

Impact Of Sintering Time On Corrosion Rate And Relative Density Of Titanium, Titanium-Aluminum Alloy, And Titanium-Based Composites For Bio-Applications, Marwa Hadi, Niveen Abdulkader, Layth Al-Gebory

Engineering and Technology Journal

The corrosion of implanted metals in the human body results in degradation and the release of harmful ions. Titanium and its alloys are used in biomedical applications due to their corrosion resistance and biocompatibility. This study examines how the amount of time spent sintering affects the density and corrosion resistance of Ti, Ti-6% Al, and Ti-6 % Al-2% HA (hydroxyapatite). Al was incorporated into Ti to reduce its density and enhance corrosion resistance. In contrast, HA was added at 2%, which aims to improve bioactivity and facilitate better integration with bone tissue. The samples were fabricated through powder metallurgy by …

Assessment And Surface Modeling Of Cod Removal From Simulated Dairy Wastewater In A Continuous Advanced Oxidation Reactor, Anwar Hashim, Mohammed Salman

Engineering and Technology Journal

The paper herein shows modeling and optimization of a continuous-flow ultraviolet/hydrogen peroxide (UV/H2O2) AOP to degrade chemical oxygen demand (COD) in simulated dairy wastewater. The common conventional treatment procedures, such as biological and physicochemical processes, may be limited by the high amount of sludge formation, high costs, and poor removal of recalcitrant organic contaminants that form. This research, therefore, aims to design a more effective photochemical treatment alternative by conducting experimental studies and developing a more accurate model. A tailor-made cubic photoreactor with double 6 W low-pressure UV lamps (254 nm) was used to investigate the effect of three parameters: …

Compressive And Flexural Strength Of Mortar And Concrete Facings With Expanded Polystyrene And Particle Board Cores Sandwich Panels, Akintayo Adeniji, Bamidele Dahunsi, David Kolawole, Williams Kupolati, Everardt Burger, Jones Moloisane

Engineering and Technology Journal

Lightweight sandwich panels are mainly utilized in the aerospace and automobile industries, and are increasingly explored for sustainable construction. This study investigates the mechanical performance of sandwich panels composed of mortar and concrete facings with expanded polystyrene (EPS) and particle board (PB) cores. Mortar facings were a 1:3 mix of cement and sand, a 0.65 water-cement ratio, and a 1:2:4 mix of cement, sand, and granite for the concrete, with a 0.5 water-cement ratio. Cube (75 × 75 × 75 mm3) and prism (100 × 100 × 400 mm3) samples were fabricated with 15 mm facings and 45 mm cores, …

Bridging The Lab-Field Gap: A Reproducible Protocol For Decentralized Production Of Sawdust-Cement Ceiling Boards In Low-Resource Settings, Oloruntimileyin Akintade, Timothy Adeyi, James Aribisala, John Adeyemi, Shade Ademokoya, Sunday Jegede

Engineering and Technology Journal

Sawdust-cement composites (SCC) are sustainable alternatives to conventional building materials, but they are underutilized by grassroots artisans due to the limited availability of reproducible methods in low-resource settings. This study develops a standardized, field-tested protocol for producing ceiling boards using mixed-species sawdust, cement, and mineral fillers with minimal technical requirements and without reliance on industrial infrastructure. The workflow from sourcing to manual hydraulic compaction was documented and validated under artisanal conditions to assess feasibility, consistency, and performance. Results showed consistent physical properties across batches: density (1620 ± 15 kg/m³), water absorption (11.2 ± 0.3%), and thickness swelling (5.6 ± 0.2%). …

Hydraulic Simulation Of Al-Badaa Regulator Operation And Its Impact On The Flow Of Al- Gharraf River, Fatima Kazim, Jaafar Maatooq, Mohammed Wahad

Engineering and Technology Journal

Surface irrigation is a widely used method for agricultural practices; however, it often suffers from low conveyance efficiency. The research investigates the hydraulic performance of a specific reach of Al-Gharraf River near Al-Badaa regulator located in Nasiriya city in southern Iraq. The primary objective of the present study is to simulate the operational mechanism of Al-Badaa regulator and evaluate its influence on upstream offtake operations. The research employs the Simulation of an Irrigation Canal (SIC) model, which is carefully calibrated and verified using values for the Manning coefficient and the discharge coefficient, alongside real-world operating scenarios. Five distinct flow conditions …

An Artificial Neural Network Model Prediction Of Mortar Strengths Reinforced With Henequen And Sisal Fibres For Sustainable Construction, Akintayo Adeniji, Williams Kupolati, Everardt Burger, Mueez Are, Jacques Snyman, Julius Ndambuki, Chris Ackerman

Engineering and Technology Journal

The increasing demand for sustainable building materials has spurred interest in using natural fibers for construction. This study evaluates the performance of henequen and sisal fibers in mortar to enhance their tensile properties and provide alternatives to synthetic fibers. Mortar samples were prepared using a 1:3 mix ratio, with fibers introduced at 0%, 0.5%, 1%, 1.5%, and 2% by weight. The particle size distribution, setting times, consistency, and water ab-sorption and tensile strength of mortar constituents and fibers were determined. Compressive and splitting tensile strength tests were conducted on samples of 75 mm cubes and 50 × 100 mm cylinders …

Plastic Roads: Evaluating The Role Of Waste Pet In Hot Mix Asphalt – A Review, Anwer Ali, Mustafa Khalid, Ahmed Adulateef, Rasha Mahmoud

Engineering and Technology Journal

Plastic pollution has become a global environmental crisis, with millions of tons of polyethylene terephthalate (PET) waste accumulating in landfills and ecosystems. One promising solution is the integration of waste PET into hot-mix asphalt (HMA), offering the dual benefits of sustainable waste management and enhanced pavement performance. This review critically examines the mechanical, environmental, and economic impacts of PET-modified asphalt. Studies indicate that PET improves rutting resistance, durability, and flexibility, with optimal performance observed at moderate PET dosages (4– 6%). However, excessive PET content (> 6%) can lead to stiffening and premature cracking, while very high PET concentrations (> 20%) …

Self-Sensing Engineered Cementitious Composites With Carbon Nanotubes And Reinforcing Fibers For Damage Detection, Shatha Ahmed, Ali Al-Dahawi, Shatha Hassan

Engineering and Technology Journal

Engineered Cementitious Composites (ECC) represent innovative construction materials that exhibit established mechanical properties and strength features. The exceptional characteristics of this substance render it a compelling option for various kinds of facilities. However, the increased implementation of ECCs necessitates monitoring the structural integrity of the systems that utilize them. This paper focuses on developing this concept by employing the traditional matrix after incorporating it with conductive fillers. These fillers transform the matrix into a functional state to sense the damage caused by various loads. Such loads include indirect tensile loads and compressive strength of mortar samples composed of cementitious matrix …

Investigating The Role Of Solvent Extraction In Altering Ph Levels For Efficient Neodymium Extraction From Magnet Scrap, Huwaidah Ahmed, Ali Aljubouri, Hanaa Al-Kaisy

Engineering and Technology Journal

Recycling rare earth elements, specifically neodymium from magnet scrap, is crucial for advancing sustainable technologies across various industries. In this research, neodymium was recovered by solvent extraction using a stock solution prepared in 200 mL by dissolving 1 g of neodymium (III) nitrate hexahydrate, Nd(NO3)3.6H2O, in 0.5 M nitric acid. Then, it was mixed with 1 M di-(2-ethylhexyl) phosphoric acid (D2EHPA) in Isopar-L, as the organic phase, and 3 M H2SO4, as the aqueous phase, with an organic/aqueous volume ratio of (1:1). Specifically, the study examined the pH variation of the aqueous phase (from 0.5 to 2). The pH of …

Traditional Machine Learning Techniques For Explainable Ai In Lung And Colon Cancer Classification, Mahmood Amer, Zainab Sultani

Engineering and Technology Journal

Lung and colon cancers are two of the most common and deadly tumors around the world, creating significant public health concerns. Artificial intelligence (AI) and machine learning (ML) have heavily improved cancer research, particularly in early detection, histopathological analysis, and personalized therapy planning. However, despite their remarkable accuracy, ML models sometimes lack transparency, making explainability crucial in medical applications. Although various machine learning (ML)-based classifications for cancer models exist, their interpretation is not understood. The current research overcomes the diagnostic gap by developing a highly accurate system that uses XAI (Explainable Artificial Intelligence) methods to clarify its predictions. We used …