Digital Commons Network^™

In Vivo Hsc Gene Therapy Enables Sustained Ecd4-Ig Expression For Siv Prevention, Chang Li, Anna K Anderson, Anne-Sophie Kuhlmann, Veronica Nelson, Audrey Germond, Hongjie Wang, Aphrodite Georgakopoulou, Sucheol Gil, Jasmin Martinez-Reyes, Andrew Riker, Shruthi Shankar Raman, Jiho Kim, Philip Ng, Donna Palmer, Michael D Alpert, Nickolas Skamangas, Charles Bailey, Tianling Ou, Christine M Fennessey, Michael Farzan, Keith R Jerome, Brandon F Keele, Hans-Peter Kiem, André Lieber, John K Bui

Faculty, Staff and Students Publications

We aim to develop an in vivo hematopoietic stem cell (HSC) gene therapy approach for the prevention and control of HIV-1 infection. Toward this goal, we engineered helper-dependent adenovirus (HDAd) 6/3+ vectors to directly transduce HSCs in vivo, enabling progeny cells to secrete eCD4-Ig, a decoy protein that broadly neutralizes HIV/simian immunodeficiency virus (SIV) isolates by mimicking the primary viral receptor CD4 and coreceptors such as CCR5. In rhesus macaques, the HDAd 6/3+ platform achieved long-term expression of an enhanced eCD4-Ig variant (“eCD4-Ig-Emm06”) that retained potent neutralization efficacy in vivo. Transduced HSCs differentiated into lymphoid and myeloid lineages …

Executive And Managerial Insights Into Developing, Launching And Operating An Expansion Sport Franchise, Cole G. Armstrong, Timothy Kellison

Faculty Research, Scholarly, and Creative Activity

Purpose – The purpose of this paper was to investigate the organisational development processes used by the National Hockey League’s most recent expansion club, the Seattle Kraken, during their launch and early operational phases. This paper specifically focuses on the organisational development processes used by upstart sport franchises during periods of environmental turbulence. Design/methodology/approach – The authors conducted semi-structured interviews with seven Seattle Kraken executives and managers involved in the organisation’s development, launch and subsequent operations during the franchise’s first several seasons. Participants included individuals from various functional areas. The empirical material was analysed using reflexive thematic analysis to identify …

Cortical-Limbic Circuit Dynamics Of Approach-Avoidance Conflict In Humans, Brooke R Staveland, Julia Oberschulte, Barbara Berger, Tamas Minarik, Olivia Kim-Mcmanus, Jon T Willie, Peter Brunner, Mohammad Dastjerdi, Jack J Lin, Elizabeth L Johnson, Michelle Paff, Ming Hsu, Robert T Knight

2020-Current year OA Pubs

Choosing to approach or avoid is common in everyday life and excessive avoidance is a cardinal feature of anxiety disorders. We use intracranial EEG to define a prefrontal-limbic circuit supporting approach and avoidance. Presurgical epilepsy patients (n = 20) performed an approach-avoidance conflict decision-making task inspired by the arcade game Pac-Man, where patients trade off rewards against losses from ghost attack. During approach, theta power increases across a limbic circuit including the hippocampus, amygdala, orbitofrontal cortex and anterior cingulate cortex, which drops during avoidance. Theta connectivity between this circuit and lateral prefrontal cortex increases during approach and falls during avoidance. …

Spatial Transcriptomic Landscape Of Invasion Patterns In Human Papillomavirus-Associated Endocervical Adenocarcinoma, Margaret L Axelrod, Ruiwen Zhou, Lulu Sun

2020-Current year OA Pubs

Human papillomavirus (HPV)-associated endocervical adenocarcinoma is the second-most common cancer of the uterine cervix. HPV-associated endocervical adenocarcinoma can be classified into histologic Silva patterns of invasion, which are associated with clinical outcome. However, the mechanisms underlying these patterns of invasion are incompletely understood. We used whole transcriptome spatial transcriptomics to examine gene expression differences separately in the tumor epithelium and the surrounding stromal immune microenvironment (SIME). Seven cases were evaluated, focusing on cases with two distinct patterns of invasion within the same tumor, to control for inter-patient heterogeneity. The most strongly upregulated pathways in both higher-risk tumor epithelium and SIME …

Interim Estimates Of 2025-26 Seasonal Influenza Vaccine Effectiveness - United States, September 2025-February 2026., Patrick Maloney, Emily L. Reeves, Kristina Wielgosz, Ashley M. Price, Karthik Natarajan, Malini B. Desilva, Kristin Dascomb, Nicola P. Klein, Sara Y. Tartof, Stephanie A. Irving, Shaun J. Grannis, Toan C. Ong, Zachary A. Weber, Jennifer E. Schuster, Danielle M. Zerr, Marian G. Michaels, Julie A. Boom, Natasha B. Halasa, Mary A. Staat, Geoffrey A. Weinberg, Stacey L. House, Elie A. Saade, Krissy Moehling Geffel, Manjusha Gaglani, Karen J. Wernli, Vel Murugan, Emily T. Martin, Natalie A B Bontrager, Marie K. Kirby, Amanda B. Payne, Fatimah S. Dawood, Ayzsa Tannis, Heidi L. Moline, Sifang Kathy Zhao, Katherine Adams, Jennifer Decuir, Samantha M. Olson, Jessie R. Chung, Nathaniel Lewis, Brendan Flannery, Carrie Reed, Shikha Garg, Sascha Ellington, Cdc Influenza Vaccine Effectiveness Collaborators

Manuscripts, Articles, Book Chapters and Other Papers

In the United States, annual influenza vaccination has been recommended for all persons aged ≥6 months, including during the 2025-26 season. Interim influenza vaccine effectiveness (VE) estimates were calculated for patients with acute respiratory illness-associated outpatient visits and hospitalizations from three U.S. respiratory virus VE networks during the 2025-26 influenza season, using a test-negative case-control design. Among children and adolescents aged < 18 years, VE was 38%-41% against influenza outpatient visits and 41% against influenza-associated hospitalization. Among adults aged ≥18 years, VE was 22%-34% against influenza outpatient visits and 30% against influenza-associated hospitalization. Among children and adolescents, VE against influenza A ranged from 37% (against outpatient visits) to 42% (against hospitalization) across settings; among adults, VE against influenza A ranged from 30% (against hospitalization) to 34% (against outpatient visits) across settings. Among children and adolescents, VE against influenza A(H3N2)-associated outpatient visits was 35% and against influenza A(H3N2)-associated hospitalization was 38%. VE against influenza B outpatient visits ranged from 45%-71% among children and adolescents and was 63% among adults. Other estimates of VE were not statistically significant or were not reportable. Although interim influenza VE is lower during the 2025-26 influenza season than it was during recent influenza seasons, these findings demonstrate that influenza vaccination still provides protection against influenza. CDC recommends influenza vaccination; U.S. influenza vaccines remain available for persons aged ≥6 months.

Undergraduate Research Institute Discovery 2026: Research Abstracts Booklet, Undergraduate Research Institute

Discovery Day - Prescott

No abstract provided.

Addressing Maternal Cardiovascular Mortality: The Role Of Policy In Reducing Preventable Deaths And Disparities, Matthew Mitts, Alexandra H. Latham, Christina Ackerman-Banks

Journal of Applied Research on Children: Informing Policy for Children at Risk

Maternal cardiovascular conditions now surpass hemorrhage and infection as the leading cause of pregnancy-related deaths in the United States, accounting for roughly one-third of preventable maternal fatalities. Unfortunately, stark racial and geographic inequities persist, with Black and Indigenous mothers dying at two to four times the rate of their White peers. Additionally, geography affects the risk, with rural residents facing a significantly higher risk than pregnant patients who deliver in urban centers. The physiologic changes of pregnancy function as a vascular stress test; therefore, pregnancy and postpartum offer a critical window of opportunity to identify women with a high lifetime …

Rethinking Legal Education: Demystifying Neurodiversity And Building An Inclusive Future, Jennifer Kindred Mitchell, Charlie Amiot

The Journal of Law Teaching and Learning

This article contributes significantly to the discourse on legal education by arguing that embracing neurodiversity not only enhances the learning environment for all students but also cultivates a legal profession that is truly reflective of societal diversity. Ultimately, neurodiversity should be embraced as an asset. By adopting inclusive practices, legal education can nurture the promise of ND students and improve outcomes for all. This article seeks to inspire a new paradigm that celebrates neurocognitive diversity’s contributions to the legal profession.

Neurodivergent (ND) students comprise approximately a quarter of the law school population, yet traditional legal education often fails to meet …

Multi-Dimensional Research Appraisal: A Holistic Approach To Evidence-Informed Practice, John Damiao

Translational Science in Occupation

The field of occupational therapy (OT) and healthcare in general have made great strides in enhancing their scientific rigor through study methodologies that prioritize internal validity. However, concerns regarding reproducibility and replicability in research have cast doubt on traditional evidence-based models. This paper critically examines the limitations of an over-reliance on internal validity in evidence reviews and advocates for a multi-dimensional approach to evidence-based practice. By integrating methodological holism, contextual analysis, and a critical appraisal of external validity, this approach provides practitioners with a more nuanced and applicable framework for decision-making. The implications for research credibility and clinical confidence are …

Development And Validation Of A Life Participation Self-Assessment Tool For People Living With Obesity: The Life Participation Impact Questionnaire (Lpiq-O), Marie-Claude Touchette

Translational Science in Occupation

Purpose: Obesity is a chronic condition affecting over 40% of adults in the U.S. Given the well-documented impact of obesity on life participation, a comprehensive, population-specific assessment tool is needed. We aimed to establish the face and content validity of the Life Participation Impact Questionnaire for People with Obesity (LPIQ-O), an occupation-focused assessment tool measuring the impact of obesity on areas of life participation.

Method: This study included seven iterative phases: (a) literature review, (b) interviews, (c) synthesis of the literature review and interviews, (d) item development, (e) expert validation, (f) face validation, and (g) final expert review. Six participants …

Integration Of The Science Of Team Science (Scits) With Applied Healthcare Frameworks: Interprofessional Education Through A University-Based Head Injury Clinic, Part Ii: Mixed Methods, Emily Balog, Susan Paparella, Natalia Noce, Stephanie Hubbell, Kelly Pena

Translational Science in Occupation

Introduction: Effective healthcare delivery requires clinicians to function within high-performing, collaborative teams. To support this, interprofessional education (IPE) must provide opportunities that move beyond siloed training. This paper details the clinical application of a team science-informed educational intervention designed to prepare students for interprofessional practice (IPP) through a university-based head injury head injury clinic. Methods: The research team conducted a mixed methods case study with a convergent design to evaluate student outcomes. Eighteen graduate students from occupational therapy, physical therapy, and speech-language pathology participated in a 10-week clinic. Faculty delivered training in IPEC competencies, TeamSTEPPS® tools, and clinical processes before …

Editors' State Of The Journal: Making Academic Writing Accessible, Nicole Martino, Nancy E. Krusen, Stacy Smallfield

Translational Science in Occupation

No abstract provided.

Insecure Attachment Predicts Poor Sexual Communication Among Emerging Adults, Carson T. O'Leary

Pursuit - The Journal of Undergraduate Research at The University of Tennessee

Sexual communication significantly predicts sexual satisfaction within adult romantic relationships (Byers, 2011). Further, research has demonstrated that relationship satisfaction and relationship outcomes are positively influenced by sexual satisfaction (Anderson, 2012). Research regarding interest in promoting long-term romantic relationships should target sexuality-related concerns in romantic partners. Sexuality research grounded in attachment theory has provided promising results. Attachment theory hypothesizes that individuals develop an attachment style based on early life experiences with their caregiver(s). These styles strongly predict how individuals respond to loved ones, including romantic partners (Bell & Ainsworth, 2023). Research also suggests insecurely attached individuals struggle with effective communication in …

Pedaling Through Discomfort: A Feasibility Study Of Faculty-Led Spin Classes And Their Impact On Student Engagement, Resilience, And Faculty-Student Relationships, Gabriela Baza, Elizabeth Hathaway

Pursuit - The Journal of Undergraduate Research at The University of Tennessee

This study explored the feasibility and impact of faculty-led Spin classes on college students’ engagement, well-being, and connection with faculty. Offered twice weekly at 7 AM during Fall 2024, the classes aimed to promote physical activity, resilience, and faculty-student relationships. Twenty-six students attended at least one class, with a median attendance of 4.5 sessions. Post-semester surveys (88% response rate) assessed perceived exertion, interest, enjoyment, challenge, improvement, and instructor encouragement. Students reported high levels of engagement and positive challenge (RPE = 15.3; challenge = 6.4/7). Those attending 7 or more sessions reported significantly greater perceived improvement than those attending fewer sessions …

Conjoined Twins And Abortion Restrictions: Navigating 'Ban State' Challenges, A Case Report, Beau Morgan Nrp

Pursuit - The Journal of Undergraduate Research at The University of Tennessee

This case report highlights an unusual scenario of a conjoined twin pregnancy resulting from intrauterine insemination in a state with restrictive abortion laws. Despite a diagnosis deemed not compatible with life, the patient faced legal barriers preventing termination within their home state. Forced to seek care out-of-state, the patient underwent a successful termination at ten weeks and three days after lengthy and expensive travel. This case stresses the complex challenges posed by restrictive abortion laws, impacting patient access to essential medical interventions. The case demonstrates the critical intersections between medical care, medical ethics, legal constraints, and patient outcomes in managing …

Investigating Corollaries Between Streptococcus Gallolyticus Subsp. Gallolyticus Virulence And Colorectal Cancer, Tyler G. Myers

Pursuit - The Journal of Undergraduate Research at The University of Tennessee

Streptococcus gallolyticus subsp. gallolyticus (Sgg) is a gram-positive, non-beta-hemolytic bacterium that belongs to the Lancefield group D of streptococcal pathogens. For the past several decades, associations between Sgg bacteremia and colorectal cancer (CRC) have been apparent, with gastroenterologists routinely recommending colonoscopies for positive cases of Sgg in either blood or stool samples. However, current research has not wholly established whether Sgg acts as a causative agent of CRC or if pre-existing cancers make the lumen of the colon more hospitable to its colonization. Regardless, Sgg has been implicated in the modulation of host inflammatory pathways and subsequent remodeling …

Lsu Health New Orleans School Of Dentistry Welcomes Esperanza Academy For Give Kids A Smile Day

New Orleans Dental Association News

LSU Health New Orleans School of Dentistry (LSUSD) reinforced its long standing commitment to community oral health by welcoming approximately 120 first, second, and third graders from Esperanza Academy for this year’s Give Kids a Smile Day—a national initiative dedicated to expanding access to dental care and oral health education for children

The article showcases the event services, activities, contributors, and fun photos full of costumes.

Sun Life U.S. And Dentaquest Announce 2025 Recipients Of The Health Access Hero Awards

New Orleans Dental Association News

Sun Life and DentaQuest's Health Access Hero Awards recognize nonprofits and individual change-makers working to broaden access to health services and improve health outcomes for communities in need. One of the 2025 Health Access Hero Award winners is in NODA's own backyard: Dr. Douglas Cross, Dental Director at EXCELth Inc. Learn about both Dr. Cross and the awards in the article.

Noda News March 2026

New Orleans Dental Association News

New Orleans Dental Association (NODA) News includes regular columns with regional news impacting the New Orleans membership including: columns from the President and Executive Director, feature articles relating to the field of dentistry, association events and upcoming activities, component news, continuing education opportunities, and classifieds.

2025 Noda Honor Dentist: James “Jimmy” Edward Burns, D.D.S., David J. Hildebrandt D.D.S.

New Orleans Dental Association News

The New Orleans Dental Association Honors & Awards committee is pleased to announce the recipient of the 2025 Honor Dentist: Dr. James "Jimmy" E. Burns. Dr. Burns is an LSU graduate and avid LSU football fan. He is a member of many professional dental groups and an advocate of organized dentistry. Within the article he credits several professional mentors and his father as role models.

The NODA Honor Dentist Award is presented annually “In Recognition of Outstanding Contributions And Exemplary Conduct in the Profession of Dentistry”.

Noda News February 2026

New Orleans Dental Association News

New Orleans Dental Association (NODA) News includes regular columns with regional news impacting the New Orleans membership including: columns from the President and Executive Director, feature articles relating to the field of dentistry, association events and upcoming activities, component news, continuing education opportunities, and classifieds.

The Human Rights Fulcrum: Using Environmental Rights As Leverage For Change, Rebecca Bratspies

Pace International Law Review

“Give me a lever long enough and a firm place on which to stand and I will move the earth." That is how Archimedes famously described the power of levers and the possibility they create for moving something that otherwise seems immovable. His point was that with the use of distance, a fulcrum, and a lever, nothing is really immovable. This same characterization has been applied to human rights law, and its attempts to disrupt patterns of structural dispossession, discrimination and oppression that bedevil human society. Indeed, the metaphor that human rights are a lever for change is relatively common …

The (Non-) Protection Of Indigenous Rights In Isds, Dr. Kevin W. Gray

Pace International Law Review

International investment law largely flows from the protections afforded foreign investors under bilateral and multilateral investment treaties.  Until recently, few of these treaties required investors to comply with human rights provisions in national constitutions or in international law, or preserved the ability of states to regulate to protect constitutional rights.  As a result, critics have argued, investor-state dispute settlement fails to protect human rights or preserve the ability of states to regulate in the public interest, and that arbitral awards rarely consider, let alone give effect to, rules of human rights.

This article considers the question of how Indigenous rights, …

Analysing Numeracy Demands In Alberta Curriculum: A Focus On High School Mathematics, Asia Majeed, Kwesi Yaro

Numeracy

In recent years, numeracy has been recognized as a key educational priority across the curriculum in many international jurisdictions, including almost all Canadian provinces. In Alberta province, Canada, for example, the Teaching Quality Standard (TQS) #3 explicitly states that all teachers are responsible for fostering literacy and numeracy skills, regardless of the specific subject areas they teach. This expanded focus reflects a broader understanding of numeracy not merely as a subset of mathematical skills, but as a fundamental competency that supports informed participation in civic, economic, and personal life. This paper applies the 21st Century Numeracy Model (Goos et al., …

Tbi Semi-Annual Report July-December 2024, Tennessee. Bureau Of Investigation.

Annual Report

No abstract provided.

2025 Child Fatality Annual Report, Tennessee. Department Of Health.

Child Fatalities in Tennessee Report

No abstract provided.

The Savage Ontology V2: A Complete Physical Theory Of Certified Computation, Nick Y. Savage

Defensive Publications Series

Defensive publication establishing prior art for the Savage Ontology — a closed, self-consistent physical theory of certified computation consisting of eight theses: (1) Information has physical observables (Flux Tensor), (2) The computational manifold is triply constrained (symplectic, holographic, causal), (3) Computational time is derived from topology (Topological Clock), (4) The system converges to a golden-ratio-governed fixed point (φ from α²−α−1=0), (5) Self-repair is a theorem (100/100 adversarial attacks repaired), (6) Cognition is thermodynamic (Landauer-complete), (7) Computation is causally isolated (Causal Diamond), (8) The Savage Limit εs=10⁻⁶ certifies every state transition.

Architecture: SIA-v6 (Symplectic Inference Architecture, Version 6) Verification: 1,565/1,565 test …

Adapting Biometric Data Broadcast Rate Based On Physiological State And Receiver Capabilities, Sudeep Chauhan, Sumukh Shevde

Defensive Publications Series

Static, fixed-rate broadcasting of biometric data from wearable devices can lead to inefficient power consumption, as data transmission frequency may not align with a user's activity level or a receiving equipment's needs. A system is described for adaptively controlling wireless transmission parameters based on real-time conditions. A data-source device, such as a wearable computer (e.g., a smartwatch, fitness tracker, or augmented reality device), can analyze a user's physiological state to classify activity levels, for instance, a steady state or a high-variability state. Concurrently, the device may negotiate capabilities with a data-receiving device, such as exercise equipment (e.g., a treadmill or …

Personalized Environmental Risk Alerting Via Fusion Of Physiological, Environmental, And Contextual Data, Sumukh Shevde, Sudeep Chauhan

Defensive Publications Series

Personal health monitoring devices may detect physiological changes but can lack environmental context to determine a cause, while environmental alert systems may rely on generic, non-personalized data. Systems and methods are described that can algorithmically fuse multiple data streams. These streams can include real-time physiological data from a wearable computing device (e.g., a smart watch, fitness tracker), such as heart rate variability; hyperlocal environmental data, such as air quality or noise levels; and contextual data, such as a user's location and activity level. This fusion of data may be used to compute a personalized risk index. The index may then …

Perioperative Fluid Management In Cardiac Surgery: Contemporary Evidence And Clinical Controversies, Hussein Ali Hussein Al-Hchaimi, Hussein Alkhfaji, Majid Fakhir Al-Hamaidah, Mohammad Ali Hassan Jassim, Ammar Hoom Mahdi, Fatima Al-Sharwood, Sunder Etta

AUIQ Complementary Biological System

Perioperative fluid therapy is a cornerstone of anesthetic management in cardiac surgery, where both hypovolemia and hypervolemia are associated with increased morbidity, forming a ``U-shaped'' relationship with outcomes. This narrative review synthesizes evidence from peer-reviewed literature (2000–2024) identified via PubMed, Scopus, and the Cochrane Database, focusing on randomized trials, meta-analyses, and guidelines for adult cardiac surgery. A central debate persists regarding fluid choice. Current evidence supports the preferential use of balanced crystalloids over normal saline, as large-volume saline is linked to hyperchloremic acidosis and reduced renal perfusion. Colloids like albumin and hydroxyethyl starch (HES) offer efficient volume expansion but require …