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Articles 27961 - 27990 of 1791765
Full-Text Articles in Entire DC Network
The Effects Of Affordability And Quality Of Care On Utilization Of Primary Healthcare Among Rural Residents In Twifo Ati-Morkwaa District, Ghana: A Qualitative Study, Peter Ansah Boakye, Francis Tei-Nartey, Gideon Owusu
The Effects Of Affordability And Quality Of Care On Utilization Of Primary Healthcare Among Rural Residents In Twifo Ati-Morkwaa District, Ghana: A Qualitative Study, Peter Ansah Boakye, Francis Tei-Nartey, Gideon Owusu
Michigan Tech Publications
Objective: This qualitative study examines how affordability and quality of care influence the utilization of primary healthcare (PHC) services among rural residents in the Twifo Ati-Morkwaa District, Ghana. While Ghana has implemented policies such as CHPS and NHIS to improve access, subjective experiences of rural residents regarding total costs of care and perceived quality remain underexplored. Methods: We conducted a qualitative cross-sectional study between April and September 2024 using purposive and snowball sampling. Ten gender-segregated focus group discussions (FGDs; n = 90 residents) and six in-depth interviews (IDIs) with PHC providers were conducted. Data were collected in Twi, transcribed and …
Fit Check: Making Health Assessments Work For You, Brooklynn Raacke, Ryssa Schlaefli, Caleb Ashley, Makenzie Premer, Brooke Mann, Jessica Phelan
Fit Check: Making Health Assessments Work For You, Brooklynn Raacke, Ryssa Schlaefli, Caleb Ashley, Makenzie Premer, Brooke Mann, Jessica Phelan
SACAD: Scholarly Activities
When given multiple tools to assess health, people tend to choose the one that is most familiar, fastest, or easiest to interpret. Relying solely on weight can overshadow other important indicators of health, such as body composition, cardiovascular function, and muscular development. Understanding this preference, even when other tools are available, matters for both educators and fitness professionals. This study used naturalistic observation to assess gym-goers' usage of health and anthropometric assessment tools. Results indicated that while gym-goers initially showed interest in less commonly used assessment tools, they overwhelmingly used the scale. Implications, limitations, and future directions are discussed.
Implementing A Student Standardized Patient Elective To Improve Communication And Confidence In Undergraduate Nursing Simulation, Katie J. Mcqueen
Implementing A Student Standardized Patient Elective To Improve Communication And Confidence In Undergraduate Nursing Simulation, Katie J. Mcqueen
SACAD: Scholarly Activities
Abstract
Simulation plays an important role in preparing undergraduate nursing students for clinical practice by fostering communication skills and building confidence. Currently, simulation experiences often depend on faculty and staff to play the roles of patients or family members. Research shows that nursing students can be effectively trained to serve as standardized patients, creating opportunities for peer-supported learning and improving simulation experiences. This evidence-based practice proposal recommends the implementation of a 1-credit-hour Student Standardized Patient (SSP) elective in the undergraduate nursing curriculum for senior level nursing students. The elective would provide structured training in role portrayal, safety practices, and case …
Adn Transition Program; Curriculum Changes To Promote Non-Traditional Student Retention, Sayde K. Fitzgerald
Adn Transition Program; Curriculum Changes To Promote Non-Traditional Student Retention, Sayde K. Fitzgerald
SACAD: Scholarly Activities
ADN transition program; curriculum changes to promote non-traditional student retention
Sayde Fitzgerald, BSN RN
Department of Nursing, Fort Hays State University
NURS 868: Nursing Education: Curriculum Planning
Dr. Chrstine Hober
March 29, 2026
Abstract
Barton nursing instructors have recognized retention challenges among non-traditional students entering the ADN program, a situation further complicated by a nursing shortage and high attrition rates ranging from 10% to 30% (Sheikoleslami et al., 2025). These factors significantly impede workforce development. Non-traditional students encounter distinctive difficulties in adapting to the demanding curriculum, often facing a lack of support and the need to balance personal responsibilities (Mazzotta …
Disclosure Statement Debtor's 4th Amended Plan
Disclosure Statement Debtor's 4th Amended Plan
Catholic Dioceses in Bankruptcy
No abstract provided.
Community Pharmacies Face Critical Sustainability Challenges In The United States: Academic Pharmacy Can Help, Karl M. Hess, Peter Lim
Community Pharmacies Face Critical Sustainability Challenges In The United States: Academic Pharmacy Can Help, Karl M. Hess, Peter Lim
Pharmacy Faculty Articles and Research
Community pharmacies in the United States (US) face an increasingly unsustainable future due to declining third-party reimbursement (remuneration) and ongoing cash flow challenges following the elimination of retroactive direct and indirect remuneration (DIR) fees. These pressures have contributed to widespread pharmacy closures, the emergence of pharmacy deserts, and reduced access to care for millions of patients. Despite these challenges, community pharmacy remains the most common employment setting for pharmacy school graduates in the US. However, currently required community pharmacy Advanced Pharmacy Practice Experience (APPE) student rotations may offer limited exposure to business, management, and entrepreneurial activities, potentially leaving students underprepared …
Debtor's Fourth Amended Modified Plan
Debtor's Fourth Amended Modified Plan
Catholic Dioceses in Bankruptcy
No abstract provided.
From Arrival To Opportunity: A Policy Analysis For Supporting Newly Arrived English Learners In California, Valeria Gabrielli, Stephanie Mendoza Hernandez
From Arrival To Opportunity: A Policy Analysis For Supporting Newly Arrived English Learners In California, Valeria Gabrielli, Stephanie Mendoza Hernandez
School of Public Policy Capstones
Newly arrived immigrant students, commonly referred to as “newcomers,” represent a notable portion of the English Learner (EL) population in California’s K–12 public schools. As of Fall 2023, the California Department of Education reported that newcomers comprised 3.27% of total student enrollment. Although enrollment is projected to decline in the near term, the potential for future increases highlights the need for sustainable, evidence-based support systems. This study examines how California K–12 public schools with large EL populations provide academic and trauma-informed support services to newcomer students, with a particular focus on early intervention in grades K–5. Using the Bardach policy …
Increased Use Of Generative Ai-Associated Language In Residency Personal Statements, Darrow Traylor, Andrea Carlson, Elise Lovell, Ravi Chacko, Ryan Mckillip
Increased Use Of Generative Ai-Associated Language In Residency Personal Statements, Darrow Traylor, Andrea Carlson, Elise Lovell, Ravi Chacko, Ryan Mckillip
Advocate GME
No abstract provided.
The Use Of Fire Stations As Satellite Campuses Impact On Paramedic Recruitment, Training, And Retention, Joseph D. Levy
The Use Of Fire Stations As Satellite Campuses Impact On Paramedic Recruitment, Training, And Retention, Joseph D. Levy
Ed.D. Capstone Reports
The ongoing national shortage of paramedics presents a critical challenge for emergency medical services (EMS), placing immense pressure on agencies to maintain adequate staffing levels while meeting the growing demand for emergency response. Workforce attrition, increasing call volume, limited access to paramedic education, and high burnout rates have compounded this crisis, threatening the sustainability of EMS operations. This capstone examines strategies to improve paramedic student recruitment, training, and retention, with a focus on utilizing fire stations as satellite training campuses to expand access to education and workforce development.
This study is guided by Human Capital Theory and Self-Determination Theory, analyzing …
HawaiʻI’S Housing Crisis: Unpacking The Limits Of S.B. 2919, Carley Matsumoto
HawaiʻI’S Housing Crisis: Unpacking The Limits Of S.B. 2919, Carley Matsumoto
Seattle University Law Review Online
The State of Hawaiʻi is facing a housing crisis exacerbated by natural disasters and public health emergencies. Hawaiʻi’s legislature seeks to ameliorate Hawaiʻi’s housing crisis with Senate Bill 2919, which gives all counties in Hawaiʻi the broad power to regulate short-term rentals. While this law was adopted with laudable intentions, it has significant shortcomings and will likely not solve Hawaiʻi’s longstanding housing crisis. This Comment argues for an alternative, tax-based solution to address the housing crisis.
Response To Letter: Assessment Of Postoperative Range Of Motion In Pediatric Patients Undergoing Surgical Reduction And Fixation Of Lateral Condyle Fractures, Gabrielle Rogie, Timothy Borden, Lindsay Crawford, Surya Mundluru, Brennan Roper, Rohini Mahajan Vanodia, Shiraz Younas
Response To Letter: Assessment Of Postoperative Range Of Motion In Pediatric Patients Undergoing Surgical Reduction And Fixation Of Lateral Condyle Fractures, Gabrielle Rogie, Timothy Borden, Lindsay Crawford, Surya Mundluru, Brennan Roper, Rohini Mahajan Vanodia, Shiraz Younas
Faculty, Staff and Student Publications
No abstract provided.
Cilia Dynamics In Primary Ciliary Dyskinesia: A Biophysical Characterization Of The Rsph4a Founder Variant, Gabriel Rosario-Ortiz, José Muñiz-Hernández, Natalia M Ortiz-Pérez, Marcos J Ramos-Benitez, Ricardo A Mosquera, Wilfredo De Jesús-Rojas
Cilia Dynamics In Primary Ciliary Dyskinesia: A Biophysical Characterization Of The Rsph4a Founder Variant, Gabriel Rosario-Ortiz, José Muñiz-Hernández, Natalia M Ortiz-Pérez, Marcos J Ramos-Benitez, Ricardo A Mosquera, Wilfredo De Jesús-Rojas
Faculty, Staff and Student Publications
Primary ciliary dyskinesia (PCD) is a rare ciliopathy resulting in chronic oto-sino-pulmonary disease. PCD diagnosis can be achieved by a combination of different diagnostic and adjuvant tools, including high-speed video-microscopy analysis (HSVA). A founder variant has been described in Puerto Rico as the most common cause of PCD in the island. Background/Objectives: In HSVA, objective parameters such as ciliary beat frequency (CBF) and subjective parameters such as ciliary beat pattern (CBP) shed light on the biophysical properties of cilia. However, the subjective nature of CBP creates a gap in knowledge; characteristics such as the length, angle, and bending index of …
Which Aspects Of Abortion Care Do Healthcare Practitioners In Britain Think Nurses/Midwives Should Provide? Findings From The Sacha Study, Rebecca French Sacha Study Team, Alice Fulton, Ona Mccarthy, Jill Shawe, Rebecca Meiksin, Maria Lewandowska, Melissa Palmer, Rachel Scott, Kaye Wellings, Patricia Lohr, Geoffrey Wong, Sally Sheldon, Annette Aronsson, Paula Baraitser, Sharon Cameron, Louise Keogh, Clare Murphy, Wendy V. Norman, Jennifer Reiter, Natasha Salaria
Which Aspects Of Abortion Care Do Healthcare Practitioners In Britain Think Nurses/Midwives Should Provide? Findings From The Sacha Study, Rebecca French Sacha Study Team, Alice Fulton, Ona Mccarthy, Jill Shawe, Rebecca Meiksin, Maria Lewandowska, Melissa Palmer, Rachel Scott, Kaye Wellings, Patricia Lohr, Geoffrey Wong, Sally Sheldon, Annette Aronsson, Paula Baraitser, Sharon Cameron, Louise Keogh, Clare Murphy, Wendy V. Norman, Jennifer Reiter, Natasha Salaria
School of Nursing and Midwifery
Aim: To explore the views of healthcare practitioners in Britain regarding the role of midwives and nurses in the delivery of medical and surgical abortion. Design: An observational study of the Shaping Abortion for Change study healthcare practitioner survey (2021–2022). Methods: Relationships between healthcare practitioner type, participant characteristics, knowledge of and attitudes towards abortion, and views about nurses' and midwives' role in abortion care were examined using Pearson's Chi-squared tests of association and multivariable logistic regression. Results: Amongst 763 participants including doctors, nurses, midwives and pharmacists, 71.6% supported specialist nurses in sexual and reproductive health and abortion clinics and hospitals, …
Case Study: Unique Presentation Of Odontogenic Keratocyst (Okc), Austin J. Davies, Ladan Daly, Jesse M. Fa, Bernadette Alvear Fa
Case Study: Unique Presentation Of Odontogenic Keratocyst (Okc), Austin J. Davies, Ladan Daly, Jesse M. Fa, Bernadette Alvear Fa
Oral Health
Optimized patient centered care in complex surgical cases requires comprehensive preparation through both clinical examination and radiographic interpretation. Our case demonstrates how diagnostic imaging can reveal critical radiographic findings that alter treatment approach. Pre-operative preparation involving thorough clinical and radiographic examination, in combination with excellent clinician rapport, leads to a biopsychosocial approach to dental treatment, emphasizing whole patient care.
Biopsy returned from oral pathology with diagnosis of odontogenic keratocyst (OKC). At the time of publication, the patient is nearing definitive treatment of the cystic lesion with enucleation and removal of tooth #16. In our case, thorough radiographic interpretation, the professional …
Nano Zinc Oxide Against Bacteria Isolated From Burn Infection, Mohammed Jaafar Al-Anssari, Mohammed Sahib Al-Hamami, Hayder Razzaq Al-Ameedee, Rabab Abdul Razzaq Kasema, Hawraa Majid Mahdi
Nano Zinc Oxide Against Bacteria Isolated From Burn Infection, Mohammed Jaafar Al-Anssari, Mohammed Sahib Al-Hamami, Hayder Razzaq Al-Ameedee, Rabab Abdul Razzaq Kasema, Hawraa Majid Mahdi
Al-Bahir
Pseudomonas aeruginosa is a type of bacteria that is found commonly in the environment, like in soil and in water. This bacteria can cause infections in the blood, lungs (pneumonia), or other parts of the body after surgery. These bacteria are constantly finding new ways to avoid the effects of the antibiotics used to treat the infections they cause. Zinc oxide nanoparticles' (ZnO-NPs') or Nano zinc oxide antibacterial properties have drawn a lot of attention from around the world, especially since nanotechnology has been used to create particles in the nanometer range. Because of their larger specific surface area and …
Rooted In Purpose, Driven To Lead, Payne Center For Leadership Development, Gonzaga University
Rooted In Purpose, Driven To Lead, Payne Center For Leadership Development, Gonzaga University
Payne Center Publications
Explore the program for the second annual Payne Center for Leadership Development Student Leadership Conference. This conference took place on March 28th, 2026, at Gonzaga University. Students presented on a variety of leadership topics and Morgan Marie, The Storytelling Coach gave a keynote address.
See the conference home for more information and select recordings of events from the day.
Artificial Intelligence In Mri Pre-Screening: Improving Accuracy, Safety, And Workflow Efficiency, Sara Abdin, Alyssa Sophia Garcia, Cindy Nguyen, Mackenzie Nguyen, Brianna Salinas, Saleha Zafar
Artificial Intelligence In Mri Pre-Screening: Improving Accuracy, Safety, And Workflow Efficiency, Sara Abdin, Alyssa Sophia Garcia, Cindy Nguyen, Mackenzie Nguyen, Brianna Salinas, Saleha Zafar
Research Methods Poster Session 2026
No abstract provided.
2026 Women Of Color Conference, Black Women's Blueprint
2026 Women Of Color Conference, Black Women's Blueprint
Campus Events
The Women of Color Conference, created by Bryant University’s Black Women’s Blueprint, was designed to unite women of color and provide a powerful space to share stories, knowledge, and lived experiences. Centered around the theme “Healing in Color, Honoring Our Stories, Reclaiming Our Joy,” the conference aims to foster healing as an act of resistance through storytelling, sisterhood, and collective empowerment. By creating a sacred and supportive environment, the conference uplifts voices, nurtures connection, and encourages women of color to embrace their truths, restore their spirits, and step boldly into their greatness while reclaiming the joy and identity that has …
Geospatial Analysis Of Primary Healthcare Accessibility And Qualitative Assessment Of Affordability In Rural Communities Of Twifo Ati-Morkwaa District, Ghana, Peter Ansah Boakye, Daniel Buor, Francis Tei-Nartey
Geospatial Analysis Of Primary Healthcare Accessibility And Qualitative Assessment Of Affordability In Rural Communities Of Twifo Ati-Morkwaa District, Ghana, Peter Ansah Boakye, Daniel Buor, Francis Tei-Nartey
Michigan Tech Publications
Regardless of the efforts of the government and the private sector to improve health facilities in Ghana, a significant number of rural communities still experience inadequate access to primary healthcare. This study used the mixed-methods approach to provide an overview of the geographic distribution of healthcare facilities and the accessibility and affordability of primary healthcare within the Twifo Ati-Morkwaa District. Accessibility was assessed using Euclidean buffer analysis around primary healthcare facilities, while affordability was examined qualitatively using in-depth interviews and focus group discussions with community members, community leaders and health workers. Focus group discussions and interviews were conducted using the …
Machine Learning Prediction Of Discharge Destination In Patients With Parkinson’S Disease; A Nationwide Cohort Study, Hikaru Kamo, Tejas R. Mehta, Matthew Remz, Rachael M. Burke, Anne Brooks, Adrianne Smiley, Michael S. Okun, Christopher W. Hess
Machine Learning Prediction Of Discharge Destination In Patients With Parkinson’S Disease; A Nationwide Cohort Study, Hikaru Kamo, Tejas R. Mehta, Matthew Remz, Rachael M. Burke, Anne Brooks, Adrianne Smiley, Michael S. Okun, Christopher W. Hess
Department of Neurology Faculty Papers
Risk stratification during hospitalization may support real-world discharge planning. We developed and validated machine learning models and an interpretable risk score to predict discharge destination among patients hospitalized with Parkinson's disease using a nationwide administrative claims database. Adults aged ≥50 years hospitalized between November 2017 and June 2023 were included, and the first hospitalization was defined as the index admission. Discharge destination was categorized as home, facility, or in-hospital death. The dataset was randomly divided into training (80%) and testing (20%) cohorts. Random forest models were constructed for all discharge outcomes, and an elastic net logistic regression model was developed …
Artificial Intelligence In Mri: A Dual Approach To Quality Enhancement And Time Reduction, Angelica Maria Baquedano, Marissa Elizabeth Cardoza, Jonathon H. Dajao, Maricela Garcia, Talore Lanice Jones, Saleha Zafar
Artificial Intelligence In Mri: A Dual Approach To Quality Enhancement And Time Reduction, Angelica Maria Baquedano, Marissa Elizabeth Cardoza, Jonathon H. Dajao, Maricela Garcia, Talore Lanice Jones, Saleha Zafar
Research Methods Poster Session 2026
No abstract provided.
Association Between The Dietary Index For Gut Microbiota (Di-Gm) And Colorectal Cancer In The Plco Cohort, Bezawit E. Kase, Angela D. Liese Ph.D., Jiajia Zhang Ph.D., Elizabeth Angela Murphy, Susan E. Steck Phd, Mph, Rd
Association Between The Dietary Index For Gut Microbiota (Di-Gm) And Colorectal Cancer In The Plco Cohort, Bezawit E. Kase, Angela D. Liese Ph.D., Jiajia Zhang Ph.D., Elizabeth Angela Murphy, Susan E. Steck Phd, Mph, Rd
Faculty Publications
Objectives: The study aimed to examine the association between a dietary index for gut microbiota (DI-GM) and the risk of incident colorectal cancer (CRC). Clarifying the role of diet-induced alterations in the composition and function of gut microbiota on the development of CRC can contribute to prevention efforts. Methods: Participants from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening trial enrolled in the intervention arm and who completed baseline assessments were included in the analysis (n = 55,685). The DI-GM is a literature-derived index used to score diet quality in terms of maintaining healthy gut microbiota. A time-dependent Cox model …
Association Between The Dietary Index For Gut Microbiota (Di-Gm) And Colorectal Cancer In The Plco Cohort, Bezawit E. Kase, Angela D. Liese, Jiajia Zhang, Elizabeth Angela Murphy, Susan E. Steck
Association Between The Dietary Index For Gut Microbiota (Di-Gm) And Colorectal Cancer In The Plco Cohort, Bezawit E. Kase, Angela D. Liese, Jiajia Zhang, Elizabeth Angela Murphy, Susan E. Steck
Faculty Publications
Objectives: The study aimed to examine the association between a dietary index for gut microbiota (DI-GM) and the risk of incident colorectal cancer (CRC). Clarifying the role of diet-induced alterations in the composition and function of gut microbiota on the development of CRC can contribute to prevention efforts. Methods: Participants from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening trial enrolled in the intervention arm and who completed baseline assessments were included in the analysis (n = 55,685). The DI-GM is a literature-derived index used to score diet quality in terms of maintaining healthy gut microbiota. A time-dependent Cox model …
Assessment Of Fecal Indicator Bacteria And Vendors' Handling Practices For Safety Of Salads And Raw Leafy Vegetables In Dar Es Salaam, Tanzania, Gloria B. Mrisho, Thomas J. Lyimo, Godwill D. Mrema
Assessment Of Fecal Indicator Bacteria And Vendors' Handling Practices For Safety Of Salads And Raw Leafy Vegetables In Dar Es Salaam, Tanzania, Gloria B. Mrisho, Thomas J. Lyimo, Godwill D. Mrema
Tanzania Journal of Science
Fresh leafy vegetables have gained popularity in Tanzanian cities due to their nutritional benefits and increased promotion by health practitioners. Assessment of their microbiological quality and safety is essential for determination of associated health risks. This study enumerated Fecal Indicator Bacteria (FIB) for determination of microbiological quality and safety of fresh leafy vegetable salads sold by street vendors and raw leafy vegetables obtained from Sinza market in Dar es Salaam. Handling practices, awareness and consumer satisfaction on the safety of leafy vegetable salads was also assessed among salad street vendors and consumers. Samples were collected from four stations and analyzed …
Using The Diary–Interview Method With Time-Constrained Professionals: The Case Of Journalists And Harassment, Ilmari Hiltunen, Reeta Pöyhtäri, Kaarina Nikunen
Using The Diary–Interview Method With Time-Constrained Professionals: The Case Of Journalists And Harassment, Ilmari Hiltunen, Reeta Pöyhtäri, Kaarina Nikunen
The Qualitative Report
This article presents a methodological reflection on the diary–interview method’s value and application when used with professionals whose schedules are both demanding and unpredictable, drawing on the authors’ insights from a study examining the harassment and intimidation of journalists. Our experiences demonstrate that combining solicited diary entries with recurring interviews can yield substantial advantages over using either method alone. Diaries are particularly well suited to capturing rich, situated data and individual perspectives, adding distinctive value especially when exploring sensitive or personal issues. Interviews that probe these accounts and revisit incidents in greater depth, in turn, enhance understanding of participants’ emotions, …
“Always Having To Dampen And Dilute My Essence In Order To Fit”: Intersectional Experiences Of Queer Scholars Of Color In Stem And Stem Education, Nuria Jaumot-Pascual, Lisette Torres-Gerald, Maria Ong
“Always Having To Dampen And Dilute My Essence In Order To Fit”: Intersectional Experiences Of Queer Scholars Of Color In Stem And Stem Education, Nuria Jaumot-Pascual, Lisette Torres-Gerald, Maria Ong
The Qualitative Report
This article examines the intersectional experiences of queer scholars of color in STEM and STEM education. Using arts-informed research methods, we conducted and analyzed five interviews and a focus group transcript that focused on the support and hurdles that five participants encountered and the strategies they utilized to navigate their work in STEM and STEM education. We identified that, against the backdrop of prevailing heteronormativity and normative whiteness in STEM, participants compartmentalized their STEM and social identities, felt compelled to negotiate the risks of coming out, and assumed the double burden and invisible work of students who were queer and/or …
Arts-Based Pedagogy Of Qualitative Analysis At The Graduate Level: Dwelling In The Aesthetic, Jennifer Lapum, Leinic Chung-Lee
Arts-Based Pedagogy Of Qualitative Analysis At The Graduate Level: Dwelling In The Aesthetic, Jennifer Lapum, Leinic Chung-Lee
The Qualitative Report
For those who are new to qualitative research, it can be easy to become caught up in the procedural steps and lose sight of the interpretive nature of qualitative analysis. As educators, we need to be mindful about how to teach procedural steps but also engage learners in the interpretive process of qualitative analysis. In fact, we would suggest that a rigorous approach to qualitative analysis involves applying methods in ways that create space for interpretive thinking. Theoretical insights and rich understandings of the data are derived from interpretive and creative analytical thinking often grounded in aesthetics in which we …
An Atlas Of Genetic Effects On The Monocyte Methylome Across European And African Populations, Wanheng Zhang, Chuan Qiu, Xiao Zhang, Zichen Zhang, Kuan-Jui Su, Zhe Luo, Minghui Liu, Bingxin Zhao, Lang Wu, Qing Tian, Hui Shen, Chong Wu, Hong-Wen Deng
An Atlas Of Genetic Effects On The Monocyte Methylome Across European And African Populations, Wanheng Zhang, Chuan Qiu, Xiao Zhang, Zichen Zhang, Kuan-Jui Su, Zhe Luo, Minghui Liu, Bingxin Zhao, Lang Wu, Qing Tian, Hui Shen, Chong Wu, Hong-Wen Deng
Faculty, Staff and Student Publications
No abstract provided.
The Hexosamine Biosynthetic Pathway Alters The Cytoskeleton To Modulate Cell Proliferation And Migration In Aggressive Prostate Cancer, Rajina Shakya, Praveen Suraneni, Amit Rahi, Michael Y Young, Emily Cousino, Christine B Magdongon, Raju Gajjela, Basil B Mattamana, Alexander Zaslavsky, Ganesh S Palapattu, Arun Sreekumar, Dileep Varma
The Hexosamine Biosynthetic Pathway Alters The Cytoskeleton To Modulate Cell Proliferation And Migration In Aggressive Prostate Cancer, Rajina Shakya, Praveen Suraneni, Amit Rahi, Michael Y Young, Emily Cousino, Christine B Magdongon, Raju Gajjela, Basil B Mattamana, Alexander Zaslavsky, Ganesh S Palapattu, Arun Sreekumar, Dileep Varma
Faculty, Staff and Students Publications
Castration-resistant prostate cancer (CRPC) progresses despite androgen deprivation therapy, as cancer cells adapt to grow without testosterone, becoming more aggressive and prone to metastasis. CRPC biology complicates the development of effective therapies, posing challenges for patient care. Recent gene-expression and metabolomics studies highlight the Hexosamine Biosynthetic Pathway (HBP) as a critical player, with key components like GNPNAT1 (Glucosamine-phosphate N-acetyltransferase 1) being downregulated in CRPC. GNPNAT1 knockdown in pre-clinical models has been shown to increase growth and metastasis in CRPC tumors, though the mechanisms remain unclear.To investigate the cellular basis of these CRPC phenotypes, we generated a CRISPR-Cas9 knockout model of …