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Comparative Antiscabies Efficacy Of Sonneratia Alba Extracts: Evaluation Of Plant Parts And Concentrations In Mice, Delima Engga Maretha, Lara Mukti Taresha, Karina Yuliana, Iis Ariska, Silvia Diah Lestari Mar 2026

Comparative Antiscabies Efficacy Of Sonneratia Alba Extracts: Evaluation Of Plant Parts And Concentrations In Mice, Delima Engga Maretha, Lara Mukti Taresha, Karina Yuliana, Iis Ariska, Silvia Diah Lestari

Makara Journal of Science

This study evaluated the antiscabies efficacy of 70% ethanol extracts from various parts of the mangrove Sonneratia alba (leaves, flowers, bark, and roots) as a potential alternative therapy. The primary objective was to compare the healing effects of the extracts at different concentrations on scabies lesions in mice (Mus musculus). Using a completely randomized design, 24 male Swiss Webster mice were assigned to four groups: a control (K0) group and three treatment groups to receive 10% (K1), 20% (K2), and 30% (K3) extract concentrations topically twice daily. The results demonstrated that the S. alba extracts had significant effects …


Application Of Microbial Fuel Cells For Leachate Bioremediation: The Effects Of Nutrient Nourishment, Umi Sholikah, Fidela Chosta, Tegar Palyus Fiqar, Eka Masrifatus Anifah, Riza Hudayarizka, Tadashi Hibino Mar 2026

Application Of Microbial Fuel Cells For Leachate Bioremediation: The Effects Of Nutrient Nourishment, Umi Sholikah, Fidela Chosta, Tegar Palyus Fiqar, Eka Masrifatus Anifah, Riza Hudayarizka, Tadashi Hibino

Makara Journal of Science

Leachate contains a high organic content, which can cause environmental pollution. The organic content in leachate can be removed through bioremediation using microbial fuel cell (MFC) systems to remediate pollutants and generate bioelectricity. Organic matter is important to the MFC process as both a substrate and a nutrient source. This study investigated the effects of glucose and sodium phosphate buffer nourishment on BOD, COD, and TSS removal and bioelectricity generation. This study used leachate as a substrate and a graphite rod with a surface area of about 32.98 cm2 as an electrode. The reactor uses plastic blocks with a …


Design And In Silico Modeling Of Heterocyclic-Based Xanthone Derivatives As Potential Anticancer Agents Through Tyrosine Kinase Inhibition, Yehezkiel Steven Kurniawan, Ervan Yudha, Nela Fatmasari, Radite Yogaswara, Harno Dwi Pranowo, Eti Nurwening Sholikhah, Jumina Jumina Mar 2026

Design And In Silico Modeling Of Heterocyclic-Based Xanthone Derivatives As Potential Anticancer Agents Through Tyrosine Kinase Inhibition, Yehezkiel Steven Kurniawan, Ervan Yudha, Nela Fatmasari, Radite Yogaswara, Harno Dwi Pranowo, Eti Nurwening Sholikhah, Jumina Jumina

Makara Journal of Science

Cancer is one of the deadliest diseases nowadays, and tyrosine kinase receptors play crucial roles in cancer cell survival, differentiation, proliferation, and migration. This study designed and developed a new inhibitor from heterocyclic-based xanthone derivatives to target two tyrosine kinase receptors, epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR), through in silico screening. Eighteen heterocyclic-based xanthones were evaluated through molecular docking for both receptors. All heterocyclic-based xanthones gave the root mean square deviation (RMSD) value lower than 2.00 Å. Xanthone with isobenzothiazole substituent (iBzThio) was found as the most potent inhibitor with binding energies of -10.60 and …


Anthrone-Based Dummy Molecularly Imprinted Polymer For The Selective Detection Of Fluorene And Phenanthrene In Simulated River Water, Aria Pinandita, Nurrahmi Handayani, Muhammad Iqbal, Untung Triadhi, Rusnadi Rusnadi, Samitha Dewi Djajanti, Muhammad Bachri Amran, Muhammad Ali Zulfikar Mar 2026

Anthrone-Based Dummy Molecularly Imprinted Polymer For The Selective Detection Of Fluorene And Phenanthrene In Simulated River Water, Aria Pinandita, Nurrahmi Handayani, Muhammad Iqbal, Untung Triadhi, Rusnadi Rusnadi, Samitha Dewi Djajanti, Muhammad Bachri Amran, Muhammad Ali Zulfikar

Makara Journal of Science

A dummy-template molecularly imprinted polymer (DMIP) was synthesized via precipitation polymerization using anthrone as a template analog for the selective analysis of low-molecular-weight polycyclic aromatic hydrocarbons (PAHs), specifically fluorene and phenanthrene. Styrene, benzoyl peroxide, and ethylene glycol dimethacrylate were employed as the functional monomer, radical initiator, and crosslinking agent, respectively. The synthesized polymers were characterized by Fourier-transform infrared spectroscopy, scanning electron microscopy, and particle size analysis. The imprinting factors were 1.16 and 1.09 for fluorene and phenanthrene, respectively, indicating enhanced affinity of the imprinted sites. High-performance liquid chromatography analysis following DMIP-based solid-phase extraction yielded recoveries of 91.49% ± 3.87% for …


Phytochemistry And Pharmacological Activities Of Sphagneticola Trilobata: A Systematic Review With Perspectives For Drug Discovery, Sonali Dnyaneshwar Labhade, Suraj Kamadi, Pawan Nandkishor Karwa, Ritesh Prakash Bhole, Harshad Sunil Kapare, Sohan Satyanarayan Chitlange Mar 2026

Phytochemistry And Pharmacological Activities Of Sphagneticola Trilobata: A Systematic Review With Perspectives For Drug Discovery, Sonali Dnyaneshwar Labhade, Suraj Kamadi, Pawan Nandkishor Karwa, Ritesh Prakash Bhole, Harshad Sunil Kapare, Sohan Satyanarayan Chitlange

Makara Journal of Science

Sphagneticola trilobata (L.) Pruski is a medicinal plant widely used in traditional medicine for its anti-inflammatory, antimicrobial, antioxidant, hepatoprotective, wound healing, and CNS depressant effects. Despite its broad pharmacolo-gical potential, clinical application is limited due to a lack of mechanistic understanding, standardization, and clinical validation. This review aims to provide a comprehensive overview of the phytochemical composition, pharmacological activities, and therapeutic potential of S. trilobata, while highlighting research gaps and suggesting future directions for clinical translation. A systematic review of scientific literature, ethnobotanical sources, and pharmacological studies was conducted, focusing on phytochemical analysis, biological activity, toxicity, and potential applications …


A Ferrocene-Modified Carbon Electrode Prepared From Coconut Shell Char For Cu(Ii) Detection In Water, Nabila Putri Aulia, Fitria Rahmawati, Abu Masykur, Eddy Heraldy Mar 2026

A Ferrocene-Modified Carbon Electrode Prepared From Coconut Shell Char For Cu(Ii) Detection In Water, Nabila Putri Aulia, Fitria Rahmawati, Abu Masykur, Eddy Heraldy

Makara Journal of Science

A ferrocene (Fc)-modified carbon electrode was prepared from coconut shell char (CSC), which was activated with NaOH to produce an activated coconut shell carbon (Ac-CSC). The carbon electrode was designed as a printed-carbon electrode consisting of working, counter and reference electrodes in a single piece, called a screen-printed carbon electrode, or SPCE. An Fc solution was applied to the working electrode part at 10%, 20% and 30% mass of the SPCE, producing an SPCE-Fc as an electrochemical sensor for Copper ions Cu(II) detection. The prepared activated carbon was analysed by XRD, FTIR, SEM/EDX, surface area analysis and impedance measurement to …


Lab-Made 100 Bp Dna Ladder Using Polymerase Chain Reaction And Human Dna, Muhammad Ilmam Bariqi, Zulham Yamamoto, Putri Chalya Firjatu, Luthfi Umam Hakim Nasution, Oryza Sativa Lubis Mar 2026

Lab-Made 100 Bp Dna Ladder Using Polymerase Chain Reaction And Human Dna, Muhammad Ilmam Bariqi, Zulham Yamamoto, Putri Chalya Firjatu, Luthfi Umam Hakim Nasution, Oryza Sativa Lubis

Makara Journal of Science

Polymerase chain reaction (PCR) is a rapid, molecular biology technique widely used in disease diagnosis and genetic engineering. Conventional PCR products require agarose gel electrophoresis, which employs a DNA ladder as a size reference. Most commercial ladders are plasmid-based and reliable but require additional culture time. We suggest a more efficient method for producing a DNA ladder using DNA derived from human blood. DNA was isolated using a commercial kit. Primer sets generating 100–1000 base pair (bp)-long fragments bearing target regions p12, p13, and p14 were designed using Primer-BLAST. DNA was amplified by routine PCR, visualized on a 1% (w/v) …


Dietary Oil From Hermetia Illucens L. Larvae Promotes Weight Gain And Alters Leukocyte Profiles In Mus Musculus L, Rudy Agung Nugroho Ran, Reni Kurniati, Widya Putri Ambar Sari, Reynaldo Imanuel Sompotan, Retno Aryani, Hetty Manurung, Rudianto Rudianto Mar 2026

Dietary Oil From Hermetia Illucens L. Larvae Promotes Weight Gain And Alters Leukocyte Profiles In Mus Musculus L, Rudy Agung Nugroho Ran, Reni Kurniati, Widya Putri Ambar Sari, Reynaldo Imanuel Sompotan, Retno Aryani, Hetty Manurung, Rudianto Rudianto

Makara Journal of Science

The escalating global demand for high-quality animal-derived proteins has driven the search for sustainable alternatives. Black soldier fly larvae (BSFL; Hermetia illucens L.) oil presents a promising option, by addressing organic waste management while providing nutrient-rich feed. This study evaluated the effects of dietary supplementation with BSFL oil on growth performance, hematological characteristics, and blood lipid profiles in mice (Mus musculus). Male mice were randomly assigned to five groups (n = 5): positive control (fish oil, 5 mL/kg body weight [BW]), negative control (Aquadest, 5 mL/kg BW), and three treatment groups receiving BSFL oil at 2.5, 5, and …


Liparis Condylobulbon Reichb. F. From Gumitir, Indonesia: Morphology, Molecular, And Phytochemical Profile, Fuad Bahrul Ulum, Asyifa Yasmin Arum, Kurnia Sa’Adah, Dwi Setyati, Edia Fitria Dwinianti, Ranjithkumar Rajamani, Ari Satia Nugraha, Mukhamad Su’Udi Mar 2026

Liparis Condylobulbon Reichb. F. From Gumitir, Indonesia: Morphology, Molecular, And Phytochemical Profile, Fuad Bahrul Ulum, Asyifa Yasmin Arum, Kurnia Sa’Adah, Dwi Setyati, Edia Fitria Dwinianti, Ranjithkumar Rajamani, Ari Satia Nugraha, Mukhamad Su’Udi

Makara Journal of Science

Liparis condylobulbon Rchb.f. is an epiphytic orchid across South and Southeast Asia, which holds notable ethnomedicinal and pharmacological significance. This study aims to characterize Indonesian Liparis condylobulbon using integrated morphological, molecular (matK, rbcL, ITS2), and phytochemical (LC-MS, DPPH) analyses of specimens from Mount Gumitir, providing the first comprehensive taxonomic and pharmacological profile to support species authentication and future bioprospecting. The L. condylobulbon specimen displays diagnostic epiphytic morpho-logy, including fusiform pseudobulbs, two elongate leaves, and an erect inflorescence bearing ~123 flowers. Molecular barcoding using matK, rbcL, and ITS2 confirmed its identity, with phylogenetic analyses consistently clustering it with …


Mental Health In Rural School-Age Youth: Examining Trends In Adverse Childhood Experiences, Positive Childhood Experiences, And Family Resilience From 2018-2023, Mary Katherine Shires Mar 2026

Mental Health In Rural School-Age Youth: Examining Trends In Adverse Childhood Experiences, Positive Childhood Experiences, And Family Resilience From 2018-2023, Mary Katherine Shires

Brown School Graduate Student Theses and Dissertations

This study examined trends in adverse childhood experiences (ACEs), positive childhood experiences (PCEs), family resilience, and mental health conditions in rural and urban youth in the United States from 2018-2023. It also assessed whether PCEs and family resilience moderated the association between ACEs and youth mental health and whether these relationships differed by geographic setting and across time. Data were drawn from six years (2018-2023) of the National Survey of Children’s Health (NSCH), a nationally representative, cross-sectional, caregiver-reported survey assessing child wellbeing. The analytic sample included school-age youth (ages 6-17) residing in states that reported metropolitan (urban) versus non-metropolitan (rural) …


Exploring The Process Of Using Equine-Assisted Psychotherapy To Treat Anxiety, Danica Yates Mar 2026

Exploring The Process Of Using Equine-Assisted Psychotherapy To Treat Anxiety, Danica Yates

Walden Dissertations and Doctoral Studies

Anxiety is the most rapidly growing mental health problem globally, particularly among adolescents and young adults. Mental health clinicians need effective integrative health treatment strategies to address the anxiety epidemic. The purpose of this qualitative generic study was to explore the perspectives of clinicians on the process of using equine-assisted psychotherapy (EAP) to treat adolescents and young adults with anxiety through the lens of a somatic theory, bioenergetics. Data were collected using semi-structured interviews with 12 EAP clinicians and analyzed using Braun and Clarke’s thematic analysis. Three themes were identified: 1. The process of EAP is highly effective because energetic …


Il-10, Il-17 And Vegf As Biomarkers For Differentiating Tuberculosis In North-Western Nigeria, Ibrahim Aminu Mar 2026

Il-10, Il-17 And Vegf As Biomarkers For Differentiating Tuberculosis In North-Western Nigeria, Ibrahim Aminu

Muthanna Medical Journal

Background: Cytokines mediate resistance to tuberculosis infection and play a significant role in host susceptibility and the progression of the infection. Aim: This study aimed to determine whether plasma levels of IL-17, IL-10, and VEGF can discriminate between non-resistant TB, monoresistant TB, Multidrug-resistant TB, and TB-negative subjects. Methods: Three hundred and twenty-five presumptive TB patients were recruited from 2020 to 2023 in the North-western region of Nigeria as study participants from whom sputum and blood samples were collected. The sputum samples were processed accordingly to detect drug-susceptible, monoresistant, and multidrug-resistant Mycobacterium tuberculosis (MDR-TB) using the Ziehl-Neelsen staining technique, GeneXpert, and …


Barriers And Facilitators To Accessing Addiction Treatment Services For Sexual Minority (Lgbq+) People: Systematic Review, Miriam Hillyard, Beatrice Cockbain, Colin Drummond, Katharine Rimes, Emmert Roberts Mar 2026

Barriers And Facilitators To Accessing Addiction Treatment Services For Sexual Minority (Lgbq+) People: Systematic Review, Miriam Hillyard, Beatrice Cockbain, Colin Drummond, Katharine Rimes, Emmert Roberts

School of Psychology

Background Sexual minority (lesbian, gay, bisexual, queer and other non-heterosexual) people experience significant disparities in addiction problems compared with heterosexual people.  Aims We aimed to answer the question, what are the barriers and facilitators to accessing drug/alcohol addiction treatment services for sexual minority adults?’.  Method A systematic review was conducted by searching Medline, PsycINFO, CINAHL, Web of Science, and Sociological Abstracts for any English-language primary research article (qualitative, quantitative or mixed methods) relevant to the study aims, from inception up to 18 April 2025. Quality of included studies was assessed using the Mixed-Methods Appraisal Tool (MMAT-2018). Barriers and facilitators were …


Bilateral Vocal Process Avulsion: A Rare Complication Of Laryngeal Trauma., Hye Rhee Chi, Omar Ramadan, Robert T Sataloff Mar 2026

Bilateral Vocal Process Avulsion: A Rare Complication Of Laryngeal Trauma., Hye Rhee Chi, Omar Ramadan, Robert T Sataloff

Otolaryngology (ENT) Resident Research

Vocal process avulsion is a rare and often overlooked complication of laryngeal trauma, most commonly associated with endotracheal intubation. It involves detachment of the vocal process from the body of the arytenoid cartilage, leading to dysphonia, dysphagia, voice fatigue, and/or aspiration. While strobovideolaryngoscopy and laryngeal electromyography may suggest underlying structural disruption, diagnosis can be challenging when findings are subtle or imaging is inconclusive. Definitive diagnosis and management typically involves surgical evaluation and repair to restore vocal fold tension and glottic competence. We present the first documented case of bilateral vocal process avulsion following endotracheal intubation.


Comparative Morphometric Study Of Saanen And Indigenous Goats, In Northern Pakistan, Nadar Khan, Ihsan Uddin, Sohail Khan, Hayat Ullah Khan, Muhammad Suleman Mar 2026

Comparative Morphometric Study Of Saanen And Indigenous Goats, In Northern Pakistan, Nadar Khan, Ihsan Uddin, Sohail Khan, Hayat Ullah Khan, Muhammad Suleman

Journal of Bioresource Management

Goats play an essential role in sustaining rural communities in Pakistan by providing milk, meat, and income under diverse production systems. This study compared the morphometric features of exotic Saanen goats with local breeds (Beetal, Kaghani, Gaddi, and non-descriptive) in Swat, northern Khyber Pakhtunkhwa, to evaluate growth patterns, body structure, and the potential for body weight estimation. A total of 500 animals were sampled from research stations and smallholder farms, with morphometric and qualitative traits recorded following FAO guidelines. Distinct differences among breeds were observed. Beetal goats exhibited the highest body weight (58.2 ± 2.0 kg), chest girth, and body …


The Influence Of Demographic Factors On Smoking Behavior Among Low-Income Forest Farmers: Evidence In West Java And Nusa Tenggara Provinces, Indonesia, Budiman Achmad, Dian Diniyati, Eva Fauziyah, Subarudi Subarudi, Mudji Susanto, Danarti Danarti, Rukmini Nugroho Dewi, Sri Najiyati, I Gusti Ayu Putu Mahendri, Tota Suhendrata, Demas Wamaer, Joula Olvy Maya Sondakh, Ratna Ayu Saptati Mar 2026

The Influence Of Demographic Factors On Smoking Behavior Among Low-Income Forest Farmers: Evidence In West Java And Nusa Tenggara Provinces, Indonesia, Budiman Achmad, Dian Diniyati, Eva Fauziyah, Subarudi Subarudi, Mudji Susanto, Danarti Danarti, Rukmini Nugroho Dewi, Sri Najiyati, I Gusti Ayu Putu Mahendri, Tota Suhendrata, Demas Wamaer, Joula Olvy Maya Sondakh, Ratna Ayu Saptati

Asia-Pacific Social Science Review

Smoking constitutes a significant issue in Indonesia, particularly among low-income forest farmers. Cigarettes are the second-highest household expenditure after rice, potentially comprising almost 40% of total annual income. In 2022, the prevalence of smokers aged 15 years and older was recorded at 28.26%, with West Nusa Tenggara ranking second (26.59%). This situation exacerbates poverty and reduces the quality of human resources. The study was conducted in 2023 in Ciamis Regency, Tasikmalaya (West Java), and Sumbawa (West Nusa Tenggara), areas with high cigarette consumption. The aim was to analyze the influence of demographic factors (income, age, and education) on smoking behavior …


Oral Pcsk9 Inhibitor Enlicitide Versus Oral Nonstatin Therapies: A Phase 3 Randomized Clinical Trial, Alberico L Catapano, Elina Mikhailova, Ann Marie Navar, Puja Banka, Pablo Corral, Manish Saxena, P Gabriel Steg, Subodh Verma, Andrew Yacoub Kordahi, Geraldine Mendizabal, Pengfei Zhu, Christie M Ballantyne, Coralreef Addon Investigators Mar 2026

Oral Pcsk9 Inhibitor Enlicitide Versus Oral Nonstatin Therapies: A Phase 3 Randomized Clinical Trial, Alberico L Catapano, Elina Mikhailova, Ann Marie Navar, Puja Banka, Pablo Corral, Manish Saxena, P Gabriel Steg, Subodh Verma, Andrew Yacoub Kordahi, Geraldine Mendizabal, Pengfei Zhu, Christie M Ballantyne, Coralreef Addon Investigators

Faculty, Staff and Students Publications

Background: Many adults fail to achieve guideline-directed low-density lipoprotein cholesterol (LDL-C) goals on statin monotherapy, requiring additional nonstatin lipid-lowering medication. Enlicitide, an oral proprotein convertase subtilisin/kexin 9 (PCSK9) inhibitor, lowered LDL-C by 60% compared with placebo; its efficacy compared with other oral nonstatin therapies has yet to be examined.

Objectives: This study assessed the efficacy of enlicitide, a novel oral PCSK9 inhibitor, vs other oral nonstatin therapies.

Methods: In this phase 3, randomized, double-blind, active-comparator trial, statin-treated adults aged ≥18 years with LDL-C ≥55 mg/dL and a previous major atherosclerotic cardiovascular disease (ASCVD) event, or LDL-C ≥70 mg/dL if at …


Determinants Of Stunting Among Under-Five Children (0–59 Months) In Central Sulawesi Province, Marchell Bamba, Mondastri Korib Sudaryo, Ratna Djuwita, Helwiah Umniyati Mar 2026

Determinants Of Stunting Among Under-Five Children (0–59 Months) In Central Sulawesi Province, Marchell Bamba, Mondastri Korib Sudaryo, Ratna Djuwita, Helwiah Umniyati

Jurnal Epidemiologi Kesehatan Indonesia

Stunting is caused by chronic malnutrition which can be caused by various factors including poverty, poor nutritional intake and maternal health, and inappropriate infant feeding. This study was conducted to determine what factors cause stunting in Central Sulawesi Province. This study was conducted using a cross-sectional observational analysis method using secondary data from the Survei Kesehatan Indonesia (SKI) 2023. The analysis was carried out using logistic regression. The sample used was 2179 respondents. The dependent variable is stunting while the independent variables are age, gender, area of residence, gestational age, provision of PMT, exclusive breastfeeding, maternal occupation, maternal education, and …


Prevalence And Determinant Factors Of Depression Among Pregnant Women In Poned Health Center In Tangerang City Area, Dian Geumala Hayati, Sudijanto Kamso, Popy Yuniar, Yuli Puspita Devi Mar 2026

Prevalence And Determinant Factors Of Depression Among Pregnant Women In Poned Health Center In Tangerang City Area, Dian Geumala Hayati, Sudijanto Kamso, Popy Yuniar, Yuli Puspita Devi

Jurnal Epidemiologi Kesehatan Indonesia

According to World Health Organization (WHO), approximately 10% of pregnant women experience mental disorders, with depression being particularly prevalent. In developing countries, this rate is was even higher, reaching 19.8% after childbirth and 15.6% during pregnancy. Various studies conducted in Indonesia show that the prevalence of depression among pregnant women ranges widely, from 21.4% to 26.2%.This study aimed to determine the prevalence and risk factors associated with depression during pregnancy in pregnant women at the PONED Community Health Center in Tangerang City Area. A facility-based cross-sectional study was conducted with 105 pregnant women attending antenatal check-ups at the 17 PONED …


The Relationship Between Smartphone Screen Time Duration And Individual Chronotype: A Systematic Literature Review, Diego Sergio Giasia Lumbantobing, Thalia Altamilano Pramudya Mar 2026

The Relationship Between Smartphone Screen Time Duration And Individual Chronotype: A Systematic Literature Review, Diego Sergio Giasia Lumbantobing, Thalia Altamilano Pramudya

Jurnal Epidemiologi Kesehatan Indonesia

The rapid increase in smartphone use over the past decade led to prolonged screen time across age groups, particularly during nighttime hours. Exposure to artificial light and pre-sleep digital activities was associated with circadian rhythm disruption and alterations in individual chronotype. This systematic literature review aimed to synthesize empirical evidence on the relationship between smartphone screen time duration and individual chronotype across all age groups and to identify key moderating factors influencing this association. The review was conducted in accordance with PRISMA 2020 guidelines. Literature searches were performed in PubMed, Scopus, and ScienceDirect for studies published between 2015 and 2025. …


Evaluating And Treating Pediatric Scoliosis, Bob Underwood, Michael Benvenuti, K Aaron Shaw Mar 2026

Evaluating And Treating Pediatric Scoliosis, Bob Underwood, Michael Benvenuti, K Aaron Shaw

Pediatrics in Practice: A CME Podcast

In this episode, pediatric orthopedic surgeons Aaron Shaw, DO, and Michael Benvenuti, MD, discuss how pediatricians can confidently assess, evaluate, and refer children with suspected scoliosis. They cover practical screening tips, red flags that warrant further workup, and how treatment decisions are made—from observation and bracing to surgical care—offering clear guidance for partnering with families and orthopedic specialists.

Click here to stream the podcast episode.


Physical Rehabilitation For Older Patients With Acute Hfpef (Rehab-Hfpef) Trial: Design And Rationale, Amy M. Pastva, Gordon R. Reeves, David J. Whellan, Robert J. Mentz, Haiying Chen, Alain G. Bertoni, Pamela W. Duncan, Mark A. Espeland, Shelby D. Reed, M. Benjamin Nelson, Christopher M. O'Connor, Dalane W. Kitzman Mar 2026

Physical Rehabilitation For Older Patients With Acute Hfpef (Rehab-Hfpef) Trial: Design And Rationale, Amy M. Pastva, Gordon R. Reeves, David J. Whellan, Robert J. Mentz, Haiying Chen, Alain G. Bertoni, Pamela W. Duncan, Mark A. Espeland, Shelby D. Reed, M. Benjamin Nelson, Christopher M. O'Connor, Dalane W. Kitzman

Department of Medicine Faculty Papers

RATIONALE: Older patients hospitalized for acute decompensated heart failure with preserved ejection fraction (HFpEF) experience persistently poor outcomes, including physical disability, cognitive impairment, depression, impaired health-related quality of life (HRQOL), rehospitalizations, loss of independence, and mortality. In our previous phase 2 REHAB-HF trial, an innovative physical rehabilitation intervention, delivered across three phases-inpatient, 12-week outpatient, and 3-month home-based maintenance-produced large improvements in physical function and HRQOL, with signals of reduced clinical events among patients with acute HFpEF. These findings provide a compelling rationale for a definitive, event-powered trial to evaluate clinical outcomes.

HYPOTHESIS: Targeting physical frailty and multisystem functional impairments using …


Auditory Stimulation Rescues Cognitive Deficit In Fmr1-Ko Mice, Mohamed Ouardouz, Amanda E. Hernan, J. Matthew Mahoney, Rodney C. Scott Mar 2026

Auditory Stimulation Rescues Cognitive Deficit In Fmr1-Ko Mice, Mohamed Ouardouz, Amanda E. Hernan, J. Matthew Mahoney, Rodney C. Scott

Department of Medicine Faculty Papers

Background/Objectives: Fragile X Syndrome (FXS) is a neurodevelopmental disorder caused by a triplet repeat expansion in the Fmr1 gene leading to the loss of Fragile X Messenger Ribonucleoprotein (Fmr1 protein). The loss of Fmr1 protein modulates many cell biological processes and leads to the emergence of intellectual disability and autism. FXS is modeled in Fmr1-KO mice that display features consistent with human FXS, including hypersensitivity, cognitive and learning deficits, hyperactivity and audiogenic seizures. Here, we investigated the effect of auditory stimulation during a range of developmental stages on recognition memory and sociability deficits in Fmr1-KO mice. Methods: Fmr1-KO mice were …


Deep Brain Stimulation For Psychiatric Disorders: A Systematic Review Of Molecular Imaging With Pet, Shiv Patil, Alexander Gerlach, Fnu Jeevika, Raj Patel, Emily Christner, Jaskeerat Gujral, Om H. Gandhi, Milo Writer, Nicholas M. Wang, Anastasia Kopylova, Satoria A. Zagorski, Cyrus Ayubcha, Thomas Werner, Abass Alavi, Mona-Elisabeth Revheim Mar 2026

Deep Brain Stimulation For Psychiatric Disorders: A Systematic Review Of Molecular Imaging With Pet, Shiv Patil, Alexander Gerlach, Fnu Jeevika, Raj Patel, Emily Christner, Jaskeerat Gujral, Om H. Gandhi, Milo Writer, Nicholas M. Wang, Anastasia Kopylova, Satoria A. Zagorski, Cyrus Ayubcha, Thomas Werner, Abass Alavi, Mona-Elisabeth Revheim

Student Papers, Posters & Projects

BACKGROUND: Deep brain stimulation (DBS) is an evolving technique for the treatment of various psychiatric disorders refractory to conventional pharmacotherapy. Neuroimaging with positron emission tomography (PET) has an important role in the planning, delivery, and post-surgical monitoring of DBS. This study aims to determine the clinical relevance of PET as a biomarker of disease status and response to DBS for patients with psychiatric disorders.

METHODS: We performed a systematic review of the PubMed, Web of Science, and Scopus databases to identify original research studies that applied PET to study the effects of DBS for patients with psychiatric conditions (major depressive …


Learner Leadership Practices And Student Behavior: A Cultivation Of Student Leadership, Sarun Widtayakornbundit, Jie Hu Mar 2026

Learner Leadership Practices And Student Behavior: A Cultivation Of Student Leadership, Sarun Widtayakornbundit, Jie Hu

Asia-Pacific Social Science Review

This study explored how student leadership practices (SLP) are essential in shaping learners’ development and their continued engagement with higher education institutions. This research investigates the direct and indirect effects of SLP on affective commitment (AC), employing self-efficacy (SE), individualism (IND), and collectivism (COL) as mediating variables. Data were collected through a structured online survey administered to undergraduate students from 11 public universities in Guangxi, China. The study received 436 responses and 387 valid cases. The Student Leadership Practices Inventory, the General Self-Efficacy Scale, the Individualism–Collectivism Scale, and the Affective Commitment Scale were all used as standardized tools. The analysis …


Unveiling The Effects Of Speaker Quality And Congruency On Virtual Academic Conference Outcomes, Luz Suplico Jeong, Nelson Guillen, Jr., Francia Santos, Reynaldo Bautista, Jr., Alexander Josiassen Mar 2026

Unveiling The Effects Of Speaker Quality And Congruency On Virtual Academic Conference Outcomes, Luz Suplico Jeong, Nelson Guillen, Jr., Francia Santos, Reynaldo Bautista, Jr., Alexander Josiassen

Asia-Pacific Social Science Review

The COVID-19 pandemic accelerated the adoption of virtual academic conferences (VACs), yet limited research sheds light on the effects of speaker quality and congruency on the outcomes of virtual academic conferences. This exploratory study investigates how speaker quality, speaker quality congruency, and participant motivations influence satisfaction and behavioral outcomes in VACs. Using partial least squares structural equation modeling (PLS-SEM), we analyzed data from 282 participants (academics and students) who attended virtual conferences. The study examined relationships among peer motivation, recognition motivation, speaker quality levels, speaker quality congruency, participant satisfaction, willingness to revisit, and word of mouth intentions. Results revealed that …


Hayley Williams, New Musical Era With “Ego At A Bachelorette Party”, Isabella Pizzerrato, The Rattler Mar 2026

Hayley Williams, New Musical Era With “Ego At A Bachelorette Party”, Isabella Pizzerrato, The Rattler

The Rattler

Vol. 144 Iss. 3


Cervical Dilation Assessment Simulation For Development Of Student Nurse Competency, Ashley Romans Mar 2026

Cervical Dilation Assessment Simulation For Development Of Student Nurse Competency, Ashley Romans

SACAD: Scholarly Activities

Assessment of cervical dilation is an important component in care for the pregnant and laboring patient. However, nursing students frequently encounter barriers to acquiring this assessment skill in the clinical setting. Through application of the ACE Star model, a simulation-based teaching trainer is utilized to promote achievement of student competence while respecting the limitations of the hospital clinical experience. Varied opportunities for purchasing or constructing these simulation tools allows for beneficial learning experiences at different price points, promoting the implementation of this important tool in the most appropriate method for an individual setting. Implementation of the cervical dilation simulator allows …


Adding Clinical Meaning To Hybrid Prelicensure Nursing Skills Education: Simulated Patients And Demo Medications To Reduce Modality-Based Learning Gaps, Amanda L. Rudman Mar 2026

Adding Clinical Meaning To Hybrid Prelicensure Nursing Skills Education: Simulated Patients And Demo Medications To Reduce Modality-Based Learning Gaps, Amanda L. Rudman

SACAD: Scholarly Activities

Hybrid nursing students often practice psychomotor skills in home environments that lack an authentic clinical context. This may contribute to gaps in clinical reasoning and application when compared with students who practice in on-campus settings. This difference may limit students’ ability to connect their skills to patient care situations and safely apply their knowledge in practice. The purpose of this evidence-based curriculum project is to reduce these learning gaps by using diagnosis-based simulated patient scenarios, medication administration records (MARs), and specific intravenous (IV) medications in hybrid nursing skills education. This project follows the ACE Star Model of Knowledge Transformation, which …


From Classroom To Click: Transitioning A Face-To-Face Nursing Course To An Online Learning Envrionement, Hanna Demel Mar 2026

From Classroom To Click: Transitioning A Face-To-Face Nursing Course To An Online Learning Envrionement, Hanna Demel

SACAD: Scholarly Activities

Transitioning face-to-face courses to an online learning environment presents both opportunities and challenges for both the students and the course instructors. This project focuses on the systematic redesign of a traditional face-to-face Licensed Practical Nursing (LPN) course into an engaging, student-centered focused online format. This project was done under the guidance of evidence-based instructional design. The course was restructured to promote active learning, flexibility, and accessibility while continuing the academic rigor. Emphasis was placed on fostering cognitive, social, and teaching presence to enhance the students’ engagement and learning outcomes. There were several strategies to support diverse learners and promote retention …