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College Of Engineering News, Georgia Southern University

College of Engineering & Computing: News & Publications (2010-2023)

• Five GS Students Win Georgia Engineering Foundation Scholarships
• JDRF Grant for Cesmeci to Develop Artificial Pancreas System

Final 2021 Insufficiently Reclaimed Sites Sampling Bres No. 104 Site Evaluation Summary Report, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Rational Targets Of Therapy In Extranodal Nk/T-Cell Lymphoma, Ajay Major, Pierluigi Porcu, Bradley M Haverkos

Department of Medical Oncology Faculty Papers

Extranodal NK/T-cell lymphoma (ENKTL) is an aggressive extranodal non-Hodgkin lymphoma (NHL) with poor outcomes, particularly in advanced-stage and relapsed/refractory disease. Emerging research on molecular drivers of ENKTL lymphomagenesis by next-generation and whole genome sequencing has revealed diverse genomic mutations in multiple signaling pathways, with the identification of multiple putative targets for novel therapeutic agents. In this review, we summarize the biological underpinnings of newly-understood therapeutic targets in ENKTL with a focus on translational implications, including epigenetic and histone regulatory aberrations, activation of cell proliferation signaling pathways, suppression of apoptosis and tumor suppressor genes, changes in the tumor microenvironment, and EBV-mediated …

Marginalized Populations And Trauma-Informed Practices At The Secondary Level: Understanding The Connections Between Trauma Exposure And Academic Outcomes Through An Intersectional Framework, Kirsten Hany

Theses and Dissertations

This research seeks to understand the relationship between marginalized identities and trauma in adolescents in relation to classroom outcomes, both behavioral and academic, through an intersectional framework. A synthesized review of literature as well as a quantitative study using the HSLS:09 data was conducted to discern how marginalized populations experience trauma in the school environment, and how that trauma impacts academic outcomes. The conclusions drawn through the review of literature and research suggest that marginalized students experience trauma at higher rates as well as disruption of academic outcomes. These conclusions are disseminated in chapter III which is a practitioner piece …

Saved Babies, Dead Doctors: Settler Colonial Anxiety And Strategic Rhetorics Of/In The Anti-Abortion Cultural Narrative, Cassidy Ellis

Communication ETDs

In this dissertation I identify and analyze the rhetoric that creates the anti-abortion cultural narrative and locate its toxic secrets by exposing the logics and ideologies the secrets obscure and sustain, and finally, ascertaining the strategic rhetorics that enable the narrative’s power and centrality. There are two primary arguments proposed in this dissertation. First, I argue that settler colonialism is the primary toxic secret nestled just beneath the surface of the anti-abortion cultural narrative. It is the secret that animates and sustains the narrative in service of maintaining settler colonial social order via control and maintenance of the population. Second, …

Team Moms And Tiger Moms: Formal Sports Participation And Closeness To Mothers: Supplementary Materials, Tom R. Leppard, Mikaela J. Dufur

Faculty Publications

Recent research highlights that relationships with parents are among those strengthened when youth play sports. This recent work, however, largely focuses on fathers, arguing that because of the persistent emphasis on masculinity in sporting spaces, youth sports might be especially effective at facilitating stronger relationships between fathers and children. This chapter asks how the mother-child dyad is influenced by youth formal participation in sports during their adolescence, including whether these patters differ for daughters and sons. The intense time investments the entire family unit incurs to support youth sport participation might be borne primarily by mothers; this in turn might …

Introduction: Studying Presidents And The Presidency, Lori Cox Han

Political Science Faculty Books and Book Chapters

"This chapter provides an overview of presidential studies and the current state of presidency research. Having a better understanding of topics such as the different eras usually associated with the presidency and the methods of study used by presidency scholars can aid students in learning about the various facets of the institution of the presidency as well as those who have held the office. This chapter considers the general categories used to organize presidents and their presidencies by historical eras, which provides a sense of how the institution itself, along with the day-to-day job responsibilities of the president, has evolved …

Effects Of Particle Diameter And Inlet Flow Rate On Gas-Solid Flow Patterns Of Fluidized Bed, Zhenjiang Zhao, Ling Zhou, Ling Bai, Wanning Lv, Ramesh K Agarwal

2020-Current year OA Pubs

The complex multiscale characteristics of particle flow are notoriously difficult to predict. In this study, the evolution process of bubbles and the variation of bed height were investigated by conducting high-speed photographic experiments to verify the reliability of numerical simulations. The gas-solid flow characteristics of bubbling fluidized beds with different particle diameters and inlet flow rates were systematically investigated by coupling computational fluid dynamics (CFD) and discrete element method (DEM). The results show that the fluidization in the fluidized bed will change from bubbling fluidization to turbulent fluidization and finally to slugging fluidization, and the conversion process is related to …

Slo3 In The Fast Lane: The Latest Male Contraceptive Target With A Promising Small-Molecule Inhibitor, Zhi Tan, Thomas X Garcia

Faculty, Staff and Students Publications

No abstract provided.

Fixitfelix: Improving Genomic Analysis By Fixing Reference Errors, Sairam Behera, Jonathon Lefaive, Peter Orchard, Medhat Mahmoud, Luis F Paulin, Jesse Farek, Daniela C Soto, Stephen C J Parker, Albert V Smith, Megan Y Dennis, Justin M Zook, Fritz J Sedlazeck

Faculty, Staff and Students Publications

The current version of the human reference genome, GRCh38, contains a number of errors including 1.2 Mbp of falsely duplicated and 8.04 Mbp of collapsed regions. These errors impact the variant calling of 33 protein-coding genes, including 12 with medical relevance. Here, we present FixItFelix, an efficient remapping approach, together with a modified version of the GRCh38 reference genome that improves the subsequent analysis across these genes within minutes for an existing alignment file while maintaining the same coordinates. We showcase these improvements over multi-ethnic control samples, demonstrating improvements for population variant calling as well as eQTL studies.

Lacrimal Gland Epithelial Cells Shape Immune Responses Through The Modulation Of Inflammasomes And Lipid Metabolism, Vanessa Delcroix, Olivier Mauduit, Menglu Yang, Amrita Srivastava, Takeshi Umazume, Cintia S De Paiva, Valery I Shestopalov, Darlene A Dartt, Helen P Makarenkova

Faculty, Staff and Students Publications

Lacrimal gland inflammation triggers dry eye disease through impaired tear secretion by the epithelium. As aberrant inflammasome activation occurs in autoimmune disorders including Sjögren's syndrome, we analyzed the inflammasome pathway during acute and chronic inflammation and investigated its potential regulators. Bacterial infection was mimicked by the intraglandular injection of lipopolysaccharide (LPS) and nigericin, known to activate the NLRP3 inflammasome. Acute injury of the lacrimal gland was induced by interleukin (IL)-1α injection. Chronic inflammation was studied using two Sjögren's syndrome models: diseased

Pan-Cancer Molecular Subtypes Of Metastasis Reveal Distinct And Evolving Transcriptional Programs, Yiqun Zhang, Fengju Chen, Chad J Creighton

Faculty, Staff and Students Publications

Molecular mechanisms underlying cancer metastasis span diverse tissues of origin. Here, we synthesize and collate the transcriptomes of patient-derived xenografts and patient tumor metastases, and these data collectively represent 38 studies and over 3,000 patients and 4,000 tumors. We identify four expression-based subtypes of metastasis transcending tumor lineage. The first subtype has extensive copy alterations, higher expression of MYC transcriptional targets and DNA repair genes, and bromodomain inhibitor response association. The second subtype has higher expression of genes involving metabolism and prostaglandin synthesis and regulation. The third subtype has evidence of neuronal differentiation, higher expression of DNA and histone methylation …

Emerging Treatments For Myelodysplastic Syndromes: Biological Rationales And Clinical Translation, Juan Jose Rodriguez-Sevilla, Vera Adema, Guillermo Garcia-Manero, Simona Colla

Faculty, Staff and Student Publications

Myelodysplastic syndromes (MDSs) are a heterogeneous group of clonal hematopoietic stem cell disorders characterized by myeloid dysplasia, peripheral blood cytopenias, and increased risk of progression to acute myeloid leukemia (AML). The standard of care for patients with MDS is hypomethylating agent (HMA)-based therapy; however, nearly 50% of patients have no response to the treatment. Patients with MDS in whom HMA therapy has failed have a dismal prognosis and no approved second-line therapy options, so enrollment in clinical trials of experimental agents represents these patients' only chance for improved outcomes. A better understanding of the molecular and biological mechanisms underpinning MDS …

Predicting Patient-Specific Tumor Dynamics: How Many Measurements Are Necessary?, Isha Harshe, Heiko Enderling, Renee Brady-Nicholls

Faculty, Staff and Student Publications

Acquiring sufficient data is imperative to accurately predict tumor growth dynamics and effectively treat patients. The aim of this study was to investigate the number of volume measurements necessary to predict breast tumor growth dynamics using the logistic growth model. The model was calibrated to tumor volume data from 18 untreated breast cancer patients using a varying number of measurements interpolated at clinically relevant timepoints with different levels of noise (0-20%). Error-to-model parameters and the data were compared to determine the sufficient number of measurements needed to accurately determine growth dynamics. We found that without noise, three tumor volume measurements …

Translation Quality Assessment Of Academic Research Titles: A Case Study Of Islamic Education Phd At Yarmouk University, Somia Al-Qudah

Association of Arab Universities Journal for Arts مجلة اتحاد الجامعات العربية للآداب

This study aims to examine the level of translation accuracy applied to the titles of PhD theses presented in the field of Islamic Education at Yarmouk University. A detailed analysis was conducted to reveal the types of errors present in the translation and these were subsequently categorized into six sections, based on the nature of the error. Furthermore, errors were assessed based on their impact on the translation accuracy, which determined the level of its acceptability. The findings uncovered major translation errors in the majority of the titles, many of which are the result of a shortfall in the translator’s …

A Critical Reading Of Nawal El Saadawi’S Woman At Point Zero, Sawsan Al-Darayseh

Association of Arab Universities Journal for Arts مجلة اتحاد الجامعات العربية للآداب

Women all over the world, and Egypt specifically, have been looked upon as second-class citizens for a long time in comparison to men. However, this paper argues that it is unethical for feminists, specifically here Nawal El Saadawi, to discuss this issue in an extreme way where the truth is lost. Hating men and holding them wholly at fault for the plight of women while giving alibis to and even praising women for their selfdestructive decisions is not a solution. The paper critically reads El Saadawi's Woman at Point Zero, discussing the very methods and elements that El Saadawi uses …

Comparison Of Dna Extraction Methods For Soft Tissue Samples, Steve Guzman, Nathaniel E. Hill, Mujtaba Shah, Jonathon Reynolds, Cole Farnsworth, Molly Henley, Alfred Amendolara, Laura Minor, John Dougherty Jr., John A. Kriak, Kyle B. Bills, David W. Sant

Annual Research Symposium

No abstract provided.

Vitamin C Contributes To Epigenetic Regulation Of Genes Related To Diabetic Retinopathy In Retinal Endothelial Cells, Elizabeth L. Turner, Jonathon Reynolds, Walker Kay, Marianne Becnel, Matthew Conway, Alexander Kim, John A. Kriak, Kyle B. Bills, David W. Sant

Annual Research Symposium

No abstract provided.

Determination Of Feasibility And Plausibility Of Using Various Biological Samples For Remote Genetic Testing, Cole Farnsworth, Molly Henley, Walker Kay, Varos Victer Manukyan, Jonathon Reynolds, John A. Kriak, Kyle B. Bills, David W. Sant

Annual Research Symposium

No abstract provided.

Development Of An Affordable, Manual Method Of Dna Extraction From Bones And Teeth ​, Varos Victer Manukyan, Lara Laughrey, Ryan V. Powers, Amar Paul, Davis Johnston, Dashon Eure, Todeh Toomians, John A. Kriak, Kyle B. Bills, David W. Sant

Annual Research Symposium

No abstract provided.

Breast Cancer Subtyping Of The Cancer Genome Atlas (Tcga) Samples, Spencer E. Yu, Alfred B. Amendolara, Steven T. Tung, Alexander P. Sheppert, Nasif Islam, Mindy Cook, Lena Diprizito, Nicole Lashiker, Roshni Jogin, John A. Kriak, Kyle B. Bills, David W. Sant

Annual Research Symposium

No abstract provided.

Testing Extraction Of Dna From Lipid-Rich Tissues Using Various Reagents And Commercially Available Kits, Ryan V. Powers, Walker C. Kay, Jonathon C. Reynolds, Nathaniel E. Hill, Cole J. Farnsworth, Molly E. Henley, Alfred B. Amendolara, Noah D. Boekweg, John A. Kriak, Kyle B. Bills, David W. Sant

Annual Research Symposium

No abstract provided.

Development Of A Method For Identifying And Quantifying Epicatechin In Cinnamon Extract Supplement Capsules, Danielle Valls

Annual Research Symposium

No abstract provided.

Synthetic Disulfide Derivative Of Vitamin B1, Fursultiamine, Prevents Vegf-Induced Angiogenesis, Zachary Frost, Sabrina Tran, Kota V. Ramana

Annual Research Symposium

No abstract provided.

Applications Of Platelet-Rich Fibrin In Oral And Maxillofacial Surgery, Sheva Schwartz, Claudia Freitas

Annual Research Symposium

No abstract provided.

The Science Of Oral Carbapenems, Landon Olsen, Daniel J. Yang, Aiyi Chen, Thahn-Liem Vu, H. Stephen Lee

Annual Research Symposium

No abstract provided.

Detection And Relative Quantitation Of Changes In Gene Expression Of Heat Shock Proteins 27 (Hsp27), Hsp 70, Hsp 90 And Hsp 47 In Doxorubicin-Exposed Human Cells By Rt-Qpcr, Steve Lee, Christopher So Dr.

Annual Research Symposium

Gene expression

Cell cultures

Heat shock proteins

Potential Application Of Nano-Hydroxyapatite In Tooth Decay Prevention, Gabriel Eisenhuth, Claudia Freitas

Annual Research Symposium

No abstract provided.

Fursultiamine Prevents Lung Cancer Growth ​, Noah Boekweg, Ryan Powers

Annual Research Symposium

No abstract provided.

The Effects Of Vitamin B1 Analog, Benfotiamine, On The Prevention Of Non-Small Cell Lung Cancer, Emely Fernandez, Hannah Christensen, Kota A. Ramana

Annual Research Symposium

No abstract provided.