Digital Commons Network^™

Analyzing The Anatomy Of Innovative Investment Treaty Drafting: The Quest To Safeguard The Right To Regulate, Naimeh Masumy, Carrie Shu Shang

Journal of Dispute Resolution

No abstract provided.

Why Missouri State Courts Should Implement An Online Dispute Resolution Platform To Resolve Traffic Tickets, Warrants And Please, And Misdemeanors, Emma Wormington

Journal of Dispute Resolution

No abstract provided.

Legislative Update, Wensdai Brooks, Connor Mcateer, Myca Sutton, Des'aire Taylor, Hannah Williams

Journal of Dispute Resolution

The Legislative Update exists to inform the reader of various state and federal laws passed during the 2021-2022 legislative sessions. More specifically, the statutes discussed below relate to alternative dispute resolution (“ADR”) in its many forms. This is an annual update compiled and written by the Journal of Dispute Resolution’s Associate Members and edited by the Associate Editor-in-Chief. This year represented a wide mix of laws passed—some related to health and safety in a post-pandemic world; others posed solutions to problems relevant before the COVID-19 pandemic. Usually, the Legislative Update is limited exclusively to state legislation. We decided to include …

"You're Not Gay; You're A Child Of God": Microaggressions Experienced By Lgbtq+ Teens And Their Parents In The Church Of Jesus Christ Of Latter-Day Saints, Sydney A. Sorrell, G. Tyler Lefevor, Jane H. Bell, Connor O. Berg, Samuel J. Skidmore

Psychology Faculty Publications

Like other teens in conservative religious environments, LGBTQ+ teens raised in the Church of Jesus Christ of Latter-day Saints (CJCLDS) likely experience unique microaggressions. Furthermore, like other conservatively religious parents of LGBTQ+ teens, active Latter-day Saint (LDS) parents who openly support their LGBTQ+ teens likely both witness microaggressions toward their teens and may personally experience microaggressions. The present study sought to understand parents' and teens' experiences of microaggressions in conservative religious contexts by focusing specifically on the microaggressions experienced by (a) LGBTQ+ teens raised in the CJCLDS and (b) their active LDS parents. Thematic analysis of separate interviews with 19 …

Perception And Emotional Experiences Of Medical Students Towards Human Cadaveric Dissection Across Culture, Jickssa Gemuchu, Abdo Jurjus, Jason Wasserman, Abay Zenebe, Eiman Abdel Meguid, Inaya Hajj Hussein

Conference Presentation Abstracts

No abstract provided.

Diamond Flower Compounds Show Promise In Repelling Mosquitoes, Erin Garrett

University of Mississippi News

OXFORD, Miss. – A flowering plant may provide a safe, biodegradable replacement for DEET as a primary insect repellent.

February 2023 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

Development Of A Novel Mathematical Model That Explains Sars-Cov-2 Infection Dynamics In Caco-2 Cells, Vladimir Staroverov, Stepan Nersisyan, Alexei Galatenko, Dmitriy Alekseev, Sofya Lukashevich, Fedor Ployakov, Nikita Anisimov, Alexander Tonevitsky

COVID-19 Papers, Posters, and Presentations

Mathematical modeling is widely used to study within-host viral dynamics. However, to the best of our knowledge, for the case of SARS-CoV-2 such analyses were mainly conducted with the use of viral load data and for the wild type (WT) variant of the virus. In addition, only few studies analyzed models for in vitro data, which are less noisy and more reproducible. In this work we collected multiple data types for SARS-CoV-2-infected Caco-2 cell lines, including infectious virus titers, measurements of intracellular viral RNA, cell viability data and percentage of infected cells for the WT and Delta variants. We showed …

Novel Smad3 Variant Identified In A Patient With Familial Aortopathy Modeled Using A Zebrafish Embryo Assay, Mary Burchett Sheppard, Jeffrey D. Smith, Lisa L. Bergmann, Jakub Konrad Famulski

Saha Cardiovascular Research Center Faculty Publications

In human, pathogenic variants in smad3 are one cause of familial aortopathy. We describe a novel SMAD3 variant of unknown significance (VUS), V244F, in a patient who presented with aortic root dilation, right coronary artery ectasia, abdominal aortic aneurysm, right vertebral artery atresia, and cavernoma. Determination of variant pathogenicity impacted multiple aspects of the patient’s care, including the most appropriate surgical threshold for which to recommend a valve-sparing aortic root replacement. To determine whether the newly identified SMAD3 variant, and whether SMAD3 induced aortopathy in general, can be assayed in a zebrafish embryo model, we injected smad3a mRNA into Tg[kdrl:mCherry] …

Process Intensification Strategies For Green Solvent Mediated Biomass Pretreatment, Ahamed Ullah, Yuxuan Zhang, Can Liu, Qi Qiao, Qing Shao, Jian Shi

Markey Cancer Center Faculty Publications

Demonstrated to be highly effective for lignocellulosic biomass pretreatment, deep eutectic solvent (DES) has attracted increasing attention owing to its advantages of simple synthesis, relatively low chemical cost, and better biocompatibility as compared to certain ionic liquids. Here we provide a critical review of the status of the design/selection of DES for the pretreatment of biomass feedstocks with an emphasis on the process intensification strategies: 1) integration of microwave, ultrasound, and high solid extrusion for pretreating biomass, 2) one-pot DES pretreatment, enzymatic hydrolysis, and fermentation, 3) strategies for DES recycling and product recovery; and 4) recent progress on molecular simulations …

The Parthenon, February 1, 2023, Sandra York, Conner Woodruff, Matt Schaffer, Chayce Matheny, Victoria Ware, Shauntelle Thompson, Rafael Alfonso, Scott Price

The Parthenon

No abstract provided.

Subclonal Evolution And Expansion Of Spatially Distinct Thy1-Positive Cells Is Associated With Recurrence In Glioblastoma., Wajd N Al-Holou, Hanxiao Wang, Visweswaran Ravikumar, Sunita Shankar, Morgan Oneka, Ziad Fehmi, Roel G W Verhaak, Hoon Kim, Drew Pratt, Sandra Camelo-Piragua, Corey Speers, Daniel R Wahl, Todd Hollon, Oren Sagher, Jason A Heth, Karin M Muraszko, Theodore S Lawrence, Ana C De Carvalho, Tom Mikkelsen, Arvind Rao, Alnawaz Rehemtulla

Faculty Research 2023

PURPOSE: Glioblastoma(GBM) is a lethal disease characterized by inevitable recurrence. Here we investigate the molecular pathways mediating resistance, with the goal of identifying novel therapeutic opportunities.

EXPERIMENTAL DESIGN: We developed a longitudinal in vivo recurrence model utilizing patient-derived explants to produce paired specimens(pre- and post-recurrence) following temozolomide(TMZ) and radiation(IR). These specimens were evaluated for treatment response and to identify gene expression pathways driving treatment resistance. Findings were clinically validated using spatial transcriptomics of human GBMs.

RESULTS: These studies reveal in replicate cohorts, a gene expression profile characterized by upregulation of mesenchymal and stem-like genes at recurrence. Analyses of clinical databases …

Dissolved Organic Phosphorus Removal In Secondary Effluent By Ferrate (Vi): Performance And Mechanism, Lei Zheng, Panpan Gao, Yali Song, Hua Wang, Yang Deng

Department of Earth and Environmental Studies Faculty Scholarship and Creative Works

Dissolved organic phosphorus (DOP), which is recalcitrant in municipal wastewater treatment, accounts for 26–81% of dissolved total phosphorus in the effluent. More importantly, the majority of DOP could be bioavailable, potentially threatening the aquatic environment through eutrophication. This study aimed to develop a ferrate (VI)-based advanced treatment to effectively destruct and remove DOP from secondary effluent and use deoxyribonucleic acid (DNA) and adenosine-5’-triphosphate (ATP) as DOP model compounds to explore the relevant mechanisms. The results showed that ferrate (VI) treatment could efficiently destruct and remove 75% of the DOP in secondary effluent from an activated sludge-adopted municipal wastewater treatment plant, …

Deals In The Heartland: Renewable Energy Projects, Local Resistance, And How Law Can Help, Christiana Ochoa, Kacey Cook, Hanna Weil

Minnesota Law Review Vols. 106:2 onward (2021-present)

Rural communities in every windblown and sun-drenched region of the United States are enmeshed in legal, political, and social conflicts related to the country’s rapid transition to renewable energy. Organized local opposition has foreclosed millions of acres from renewable energy development, impeding national and state-level commitments to achieving renewable energy targets in the face of the mounting climate crisis. This Article analyzes why and how communities, using county ordinances, township regulations, and electoral processes, mobilize against renewable energy companies and repel commercial wind projects. It describes the surprising and complex interplay of national, state, and municipal law governing the transition …

Dlr Covid-19 Mobility Review (Phase 2a): Report On Cmr Economic Development & Business Community Feedback, Sarah Rock Dr., Robert Bradshaw Dr., David O'Connor, Odran Reid

Reports

This research reports on the findings from an area focused economic development and business community focused study of the Costal Mobility Route (CMR), which is intended to complement and extend research previously conducted in Phase 1 of Dún Laoghaire-Rathdown County Council’s (DLR’s) ‘Covid-19 Mobility & Public Realm Works’ project. This study is based on participant interviews, and is limited to businesses located directly along the CMR, as well as a number of business groups representing a wider area and a Local Enterprise Office.

While one company reported a significant decline in revenue that they attribute to the CMR, the remainder …

One And A Half-Stage Revision With Prosthetic Articulating Spacer For Definitive Management Of Knee Periprosthetic Joint Infection., Ahmed Siddiqi, Yusuf Mahmoud, Salvador A. Forte, Thomas A Novack, James Nace

Orthopedic Surgery Resident Research

This paper is a comprehensive review that describes indications, contraindications, clinical outcomes, and pearls and pitfalls of 1.5-stage revision total knee arthroplasty (TKA) utilizing a primary TKA femoral component, all-polyethylene tibial component, and hand-crafted antibiotic cement for the management of chronic periprosthetic joint infection. The 1.5-stage exchange TKA details placement of an articulating spacer for an indefinite period, prolonging revision until reinfection, deterioration of functional status, or construct failure. A 1.5-stage revision TKA technique is a viable option for treatment of chronic periprosthetic knee infections. The inherent advantages of decreased health-care costs, decreased morbidity and mortality, and improved emotional ease …

Tennessee Bed Space And Operating Capacities Report, February 2023, Tennessee. Department Of Correction.

Bed Space & Capacity Reports

No abstract provided.

Diagnostic Metabolomic Profiling Of Parkinson's Disease Biospecimens, Peter A. Lewitt, Jia Li, Kuan-Han H. Wu, Mei Lu

Neurology Articles

BACKGROUND: Reliable and sensitive biomarkers are needed for enhancing and predicting Parkinson's disease (PD) diagnosis.

OBJECTIVE: To investigate comprehensive metabolomic profiling of biochemicals in CSF and serum for determining diagnostic biomarkers of PD.

METHODS: Fifty subjects, symptomatic with PD for ≥5 years, were matched to 50 healthy controls (HCs). We used ultrahigh-performance liquid chromatography linked to tandem mass spectrometry (UHPLC-MS/MS) for measuring relative concentrations of ≤1.5 kDalton biochemicals. A reference library created from authentic standards facilitated chemical identifications. Analytes underwent univariate analysis for PD association, with false discovery rate-adjusted p-value (≤0.05) determinations. Multivariate analysis (for identifying a panel of biochemicals …

Humanized Patient-Derived Xenograft Models Of Disseminated Ovarian Cancer Recapitulate Key Aspects Of The Tumor Immune Environment Within The Peritoneal Cavity, Mara P. Steinkamp, Irina Lagutina, Kathryn J. Brayer, Fred Schultz, Danielle Burke, Vernon S. Pankratz, Sarah F. Adams, Laurie G. Hudson, Scott A. Ness, Angela Wandinger-Ness

Pathology Research and Scholarship

UNLABELLED: The importance of the immune microenvironment in ovarian cancer progression, metastasis, and response to therapies has become increasingly clear, especially with the new emphasis on immunotherapies. To leverage the power of patient-derived xenograft (PDX) models within a humanized immune microenvironment, three ovarian cancer PDXs were grown in humanized NBSGW (huNBSGW) mice engrafted with human CD34

SIGNIFICANCE: huPDX models are ideal preclinical models for testing novel therapies. They reflect the genetic heterogeneity of the patient population, enhance human myeloid differentiation, and recruit immune cells to the tumor microenvironment.

Humanized Patient-Derived Xenograft Models Of Disseminated Ovarian Cancer Recapitulate Key Aspects Of The Tumor Immune Environment Within The Peritoneal Cavity, Mara P. Steinkamp, Irina Lagutina, Kathryn J. Brayer, Fred Schultz, Danielle Burke, Vernon S. Pankratz, Sarah F. Adams, Laurie G. Hudson, Scott A. Ness, Angela Wandinger-Ness

Pathology Research and Scholarship

UNLABELLED: The importance of the immune microenvironment in ovarian cancer progression, metastasis, and response to therapies has become increasingly clear, especially with the new emphasis on immunotherapies. To leverage the power of patient-derived xenograft (PDX) models within a humanized immune microenvironment, three ovarian cancer PDXs were grown in humanized NBSGW (huNBSGW) mice engrafted with human CD34

SIGNIFICANCE: huPDX models are ideal preclinical models for testing novel therapies. They reflect the genetic heterogeneity of the patient population, enhance human myeloid differentiation, and recruit immune cells to the tumor microenvironment.

Late Onset Paradoxical Effect Of Zolpidem After Anoxic Brain Injury: A Pediatric Case Report, Amanda Lindenberg, Sathya Vadivelu

Posters

Case Diagnosis Acquired brain injury (ABI) is a common cause of disability. It is defined as an insult to the brain that subsequently results in impairments of communication, cognition, sensorimotor function and behavior. Anoxic brain injuries can be particularly disabling. A common cause of a anoxic injury in children is cardiopulmonary arrest. The revised coma recovery scale (CRS-R) is a standardized assessment for level of arousal after brain injury. Case Description A 16 year old healthy boy was admitted after an unwitnessed pulseless cardiopulmonary arrest requiring 3 defibrillations and 2mg of epinephrine. His cardiac and genetic workup was negative. His …

Parent Satisfaction With Same Day Discharge After Laparoscopic Appendectomy For Non Perforated Appendicitis, Nelimar Cruz-Centeno, James Fraser, Shai Stewart Md, Derek Marlor, Rebecca M. Rentea, Pablo Aguayo, David Juang, Richard J. Hendrickson, Charles L. Snyder, Bhargava Mullapudi, Shawn D. St.Peter, Jason D. Fraser, Tolulope A. Oyetunji

Presentations

Background: Same-day discharge (SDD) after laparoscopic appendectomy for acute non-perforated appendicitis is safe, without an increased rate of postoperative complications, emergency department visits, or re-admissions. We aimed to evaluate caregiver satisfaction with this protocol. Materials and Methods: Patients discharged on the day of laparoscopic appendectomy for non-perforated acute appendicitis were identified between January 2022-August 2022. Surveys to evaluate satisfaction with the protocol were distributed to the caregivers via e-mail or text message 96 hours after discharge. Telephone surveys were conducted if there were no responses to the initial online survey. The surveys assessed comfort with SDD, post-operative pain control adequacy, …

2023-February-01-Etsu Health Hosting Healthcare Leadership Summit.Pdf, Iversity Marketing And Communication, East Tennessee State University

ETSU News

JOHNSON CITY – ETSU Health is hosting a Healthcare Leadership Summit for high school students from throughout the region on Tuesday, March 7, from 4-8 p.m. at East Tennessee State University’s Quillen College of Medicine.

At the summit, students will have the opportunity to learn about careers in health care, including medicine, nursing, physical and occupational therapy, emergency medical services (EMS), radiologic science, pharmacy, public health and more. Students will be divided into small groups and led by mentors to explore each health care station.

“This will be an immersive experience with hands-on activities at each station so that students …

2023-February-01-Etsu Focuses On Hands-On Learning, Sees Major Growth.Pdf, Iversity Marketing And Communication, East Tennessee State University

ETSU News

During the quarterly meeting of the East Tennessee State University Board of Trustees today, board members received reports of continued growth at the university. Overall enrollment for the spring 2023 semester is up from last year and ETSU’s spring graduate enrollment is the highest it has been in nearly a decade. Graduate enrollment numbers reached 2,396 this spring with master’s programs in computer science, information systems and public health seeing the largest growth. The university also launched a new doctor of occupational therapy program this academic year, which enrolled its first cohort of students.  

“Students – and employers – understand …

2023-February-01-Etsu Offering Free Tax Preparation Help.Pdf, Iversity Marketing And Communication, East Tennessee State University

ETSU News

JOHNSON CITY – A group of East Tennessee State University business student volunteers, under the guidance of accountancy faculty member Dr. Michelle Freeman, will offer free tax preparation assistance again this year through the Internal Revenue Service Volunteer Income Tax Assistance (VITA) Program.   

ETSU is an approved VITA location, and with financial support from Eastman Credit Union, student volunteers will assist taxpayers whose total household income was $60,000 or less during tax year 2022. Tax preparation services will be offered on the following Saturdays: Feb. 18, Feb. 25, and March 4 from 8:15 a.m.-5 p.m. at Sam Wilson Hall, room …

2023-February-01-Why I Teach- Mary Mullins.Pdf, Iversity Marketing And Communication, East Tennessee State University

ETSU News

No abstract provided.

The Process Of Sexual Misconduct By Male Teachers And Staff In K-12 Institutions, Mollee Steely Smith

Dignity: A Journal of Analysis of Exploitation and Violence

Despite the increased media attention of teachers who engage in sexual misconduct with their students, research on such incidents remains limited, specifically on how these incidents are initiated and evolve. The purpose of the current study was to examine the nature of sexual abuse incidents by K-12 teachers who engaged in sexual misconduct with students by focusing on the onset, progression, and conclusion of these cases. Data included 10 secondary narrative interviews with male sex offenders who used their position as school employees to target and engage in sexual misconduct with their students in 2014 in a southern state. All …

Summit Snapshot: Rural Personal Assistance Services, University Of Montana Rural Institute

Independent Living and Community Participation

RTC:Rural researchers and panels of individuals with lived experience present research and perspectives on rural personal assistance services at the 2023 Rural Disability Research and Practice Summit.

Defining A Cyber Operations Performance Framework Via Computational Modeling, Briant Becote

Masters Theses & Doctoral Dissertations

Cyber operations are influenced by a wide range of environmental characteristics, strategic policies, organizational procedures, complex networks, and the individuals who attack and defend these cyber battlegrounds. While no two cyber operations are identical, leveraging the power of computational modeling will enable decision-makers to understand and evaluate the effect of these influences prior to their impact on mission success. Given the complexity of these influences, this research proposes an agent-based modeling framework that will result in an operational performance dashboard for user analysis. To account for cyber team behavioral characteristics, this research includes the development and validation of the Cyber …

Endpoint Defense As Code (Edac): Configurable Contextual Analysis Of Process Behaviors From Kernel/User Event Tracing, Trevor M. Lewis

Masters Theses & Doctoral Dissertations

The current industry standard to detect cyber threat activity on endpoints (workstations, servers, etc.) centers around the use of endpoint defense software. The software products marketed are Endpoint Protection Platforms (EPP), Endpoint Detection and Response (EDR), and eXtended Detection and Response (XDR) solutions. These solutions are typically deployed onto endpoints across enterprises and monitor various aspects of each operating system for malicious activity. Current generations of these three solutions have similar underlying software architectures, user workflows, and detection capabilities. These solutions also have a number of issues that inadvertently allow advanced cyber threat actors to succeed in their operations, such …