Digital Commons Network^™

2021-2022 Annual Report, Tennessee. Public Utility Commission.

Public Utility Commission

No abstract provided.

State Of Tennessee, The Budget, Fiscal Year 2023-2024, Tennessee. Department Of Finance & Administration.

Budget Publications

No abstract provided.

Extreme Close-Up, Ant Edition, Beth Potier

UNH Today Archive

No abstract provided.

A New Wound For Old Scars: Why Act 1036 Of 2021 Is Unconstitutional And Why The Arkansas Retroactive-Legislation Doctrine Should Change, Bryce Jefferson

Arkansas Law Notes

In 2021, the Arkansas General Assembly overwhelmingly approved Act 1036, the Justice for Vulnerable Victims of Sexual Abuse Act. This Act amends the statute of limitations for “vulnerable victims” of sexual abuse. The Act allows a person who was either disabled, a minor, or both at the time he or she was a victim of sexual abuse to bring a civil action against an alleged abuser until the age of fifty-five (55)—replacing the former statutory age limit of twenty-one (21). The Act also revives previously time-barred claims for a period not earlier than six (6) months after and not later …

The Scarabaeoid Beetles Of Maryland (Coleoptera), Dana L. Price, Brett C. Ratcliffe

Zea E-Books Collection

This research recognizes 267 species of scarabaeoid beetles occurring in Maryland. We provide a brief overview of the geology, climate, and vegetation of the state. Keys to the families within Scarabaeoidea occurring in Maryland are provided. We also offer an introduction for each family, keys to all taxa, species descriptions, distributions, and distribution maps for all species, months that adults are observed, notes on their natural history, illustrations, and a glossary of terms. Maryland’s species are found in eight families: Lucanidae (7), Passalidae (1), Geotrupidae (17), Trogidae (18), Ochodaeidae (1), Hybosoridae (2), Glaphyridae (1), and Scarabaeidae (220).

Published as Bulletin …

Therapeutic Options For Covid-19: Drug Repurposing Of Serine Protease Inhibitor Against Tmprss2, Mohammad Wildan Abiyyi, Surya Dwira, Arleni Bustami, Linda Erlina

Indonesian Journal of Medical Chemistry and Bioinformatics

The SARS-Coronavirus 2 (SARS-CoV-2) outbreak is a serious global public health threat. Researchers around the world are conducting mass research to control this epidemic, starting from the discovery of vaccines, to new drugs that have specific activities as antivirals. Drug repurposing is a potential method of using drugs with known activity for reuse as COVID-19 therapy. This method has the advantage that it can reduce costs and also the duration in the development of potential drugs. The initial step in drug repurposing can be done computationally to determine the effectiveness and specificity of the drug on the target protein. Molecular …

Dynamic Cone-Beam Ct Reconstruction Using Spatial And Temporal Implicit Neural Representation Learning (Stinr), You Zhang, Hua-Chieh Shao, Tinsu Pan, Tielige Mengke

Faculty, Staff and Student Publications

Objective. Dynamic cone-beam CT (CBCT) imaging is highly desired in image-guided radiation therapy to provide volumetric images with high spatial and temporal resolutions to enable applications including tumor motion tracking/prediction and intra-delivery dose calculation/accumulation. However, dynamic CBCT reconstruction is a substantially challenging spatiotemporal inverse problem, due to the extremely limited projection sample available for each CBCT reconstruction (one projection for one CBCT volume).

Approach. We developed a simultaneous spatial and temporal implicit neural representation (STINR) method for dynamic CBCT reconstruction. STINR mapped the unknown image and the evolution of its motion into spatial and temporal multi-layer perceptrons (MLPs), and …

Labeling Compliance And Online Claims For Ayurvedic Herbal Supplements On The U.S. Market Associated With The Purported Treatment Of Covid-19, Chevon R. Jordan, Calin M. Harris, Miranda I. Miranda, Diane Y. Kim, Rosalee S. Hellberg

Food Science Faculty Articles and Research

During the COVID-19 pandemic, many consumers increased their use of supplements that claimed to support immune health, including Ayurvedic preparations. The goal of this study was to analyze labeling compliance and online claims for Ayurvedic herbal supplements associated with the purported treatment of COVID-19. The physical product labels for 51 herbal supplements labeled as ginger, tulsi/holy basil, amla, vacha/calamus root, guduchi/giloy, cinnamon, ashwagandha, tribulus, or turmeric were assessed for U.S. regulatory compliance. Disease claims, structure/function claims, and general well-being claims were also examined. The online listings for products purchased online (n = 42) were examined for claims and for the …

Hemiparkinsonism Caused By A Lateral Sphenoid Wing Meningioma, With Tractography Analysis: Illustrative Case, Attill Saemann, Stefan Busch, Ethan Taub, Birgit Westermann, Cristina Granziera, Raphael Guzman, Luigi Mariani, Jehuda Soleman, Jonathan Rychen

Faculty, Staff and Student Publications

BACKGROUND: The etiologies of parkinsonism are diverse. A possible and rare cause of hemiparkinsonism is mechanical compression of the basal ganglia and its connecting white matter tracts. The authors present a case of hemiparkinsonism caused by a lateral sphenoid wing meningioma, discuss the underlying pathophysiology based on tractography, and systematically review the existing literature.

OBSERVATIONS: A 59-year-old female was referred for a left-sided tremor of the hand, accompanied by a cogwheel rigidity of the left arm. Symptomatology appeared 1 year earlier and worsened in the previous 6 months, finally also showing involvement of the left leg. Magnetic resonance imaging (MRI) …

Patient-Reported Symptoms At Discharge And Risk Of Complications After Gynecologic Surgery, Xin Shelley Wang, Pedro T Ramirez, Qiuling Shi, Mona Kamal, Araceli Garcia-Gonzalez, Maria D Iniesta, Charles S Cleeland, Larissa A Meyer

Faculty, Staff and Student Publications

Objective: Current gaps in knowledge limit clinicians from fully implementing patient-reported outcomes in routine post-operative care.

Methods: This prospective study assessed symptoms via the gynecologic module of the MD Anderson Symptom Inventory (MDASI-PeriOp-GYN) in patients who underwent open laparotomy.

Results: At discharge, patient-reported moderate to severe (≥4 on a 0-10 scale) abdominal bloating or abdominal cramping, combined with length of stay of ≥4 days, were found to be associated with a higher risk of 30-day post-operative grade II-IV complications by the Clavien-Dindo system (all p values < 0.01). Also, length of stay of ≥4 days and moderate to severe urinary urgency at discharge were found to be associated with the need for re-admission (all p values < 0.01).

Conclusion: This study defined the clinically meaningful symptoms that related to the risk of …

Comparative Transcriptomics And Genomics From Continuous Axenic Media Growth Identifies Coxiella Burnetii Intracellular Survival Strategies, Archana Yadav, Melissa N Brewer, Mostafa S Elshahed, Edward I. Shaw

PCOM Scholarly Works

Coxiella burnetii (Cb) is an obligate intracellular pathogen in nature and the causative agent of acute Q fever as well as chronic diseases. In an effort to identify genes and proteins crucial to their normal intracellular growth lifestyle, we applied a "Reverse evolution" approach where the avirulent Nine Mile Phase II strain of Cb was grown for 67 passages in chemically defined ACCM-D media and gene expression patterns and genome integrity from various passages was compared to passage number one following intracellular growth. Transcriptomic analysis identified a marked downregulation of the structural components of the type 4B secretion system (T4BSS), …

Ohio University Faculty Senate Minutes February 6, 2023, Ohio University Faculty Senate

Faculty Senate Minutes

No abstract provided.

Trait Impressions From Voices Are Formed Rapidly Within 400ms Of Exposure, Mila Mileva, Nadine Lavan

School of Psychology

When seeing a face or hearing a voice, perceivers readily form first impressions of a person's characteristics—are they trustworthy, do they seem aggressive? One of the key claims about trait impressions from faces and voices alike is that these impressions are formed rapidly. For faces, studies have systematically mapped this rapid time course of trait impressions, finding that they are well formed and stable after approximately 100 ms of exposure. For voices, however, no systematic investigation of the time course of trait perception exists. In the current study, listeners provided trait judgments (attractiveness, dominance, trustworthiness) based on recordings of 100 …

Chimes: February 6, 2023, Calvin University

Chimes

Tuition won't go up in 2023 by Hadassa Ribeiro

Calvin winter sports claim national ranking spots by Lauren Nyong

Worship Symposium back in person after two years online by Gabriel Choi

How to actually have sweet dreams in college by Maya Oeverman

Governance review is more important than it sounds by Grace Buller

Simulation actors help nursing students prep for clinicals by Lainey Moore

Calvin seminar spreads awareness of tobacco industry strategies by David Ogboro

"A crazy, fun, only-in-college tradition": Cold Knight Plunge turns 25 by Katie Rosendale

Stop buying books; use Hekman instead by Abigail Ham

Antitumour Activity Of Neratinib In Patients With Her2-Mutant Advanced Biliary Tract Cancers, James J Harding, Haeseong Park, Et Al.

2020-Current year OA Pubs

HER2 mutations are infrequent genomic events in biliary tract cancers (BTCs). Neratinib, an irreversible, pan-HER, oral tyrosine kinase inhibitor, interferes with constitutive receptor kinase activation and has activity in HER2-mutant tumours. SUMMIT is an open-label, single-arm, multi-cohort, phase 2, 'basket' trial of neratinib in patients with solid tumours harbouring oncogenic HER2 somatic mutations (ClinicalTrials.gov: NCT01953926). The primary objective of the BTC cohort, which is now complete, is first objective response rate (ORR) to neratinib 240 mg orally daily. Secondary objectives include confirmed ORR, clinical benefit rate, progression-free survival, duration of response, overall survival, safety and tolerability. Genomic analyses were exploratory. …

The P97-Ubxd8 Complex Regulates Er-Mitochondria Contact Sites By Altering Membrane Lipid Saturation And Composition, Rakesh Ganji, Joao A Paulo, Yuecheng Xi, Ian Kline, Jiang Zhu, Christoph S Clemen, Conrad C Weihl, John G Purdy, Steve P Gygi, Malavika Raman

2020-Current year OA Pubs

The intimate association between the endoplasmic reticulum (ER) and mitochondrial membranes at ER-Mitochondria contact sites (ERMCS) is a platform for critical cellular processes, particularly lipid synthesis. How contacts are remodeled and the impact of altered contacts on lipid metabolism remains poorly understood. We show that the p97 AAA-ATPase and its adaptor ubiquitin-X domain adaptor 8 (UBXD8) regulate ERMCS. The p97-UBXD8 complex localizes to contacts and its loss increases contacts in a manner that is dependent on p97 catalytic activity. Quantitative proteomics and lipidomics of ERMCS demonstrates alterations in proteins regulating lipid metabolism and a significant change in membrane lipid saturation …

Under G-D, Dereck Daschke

Journal of Religion & Film

This is a film review of Under G-d (2022), directed by Paula Eiselt.

Factors Affecting The Satisfaction Of Sultan Qaboos University Students About Remote Academic Advising During The Covid-19 Pandemic, Abdul Rahim M. Al Droushi Phd, Khalifa Mubarak Al Jadidi Phd, Kashef Zayed Phd

International Journal for Research in Education

This study aimed to investigate the level of satisfaction of Sultan Qaboos University students with remote academic advising during the COVID-19 pandemic. It also aimed to explore the factors that might affect the extent of satisfaction, such as gender, academic year, and the nationality of the academic advisor. To achieve these aims, the researchers developed an academic advising satisfaction survey. The survey consisted of three sub-scales, namely, satisfaction with the advisor's competence and information, satisfaction with the advisor's interest and enthusiasm, and satisfaction with the ease of communication with the advisor. The survey was distributed to a sample of 490 …

Challenges Facing Undergraduate Students With Visual Impairment During Covid-19 Outbreak At Taibah University, Adel Abed Alkhaldi Phd

International Journal for Research in Education

The aim of this study was to identify the challenges faced by undergraduate students with visual impairment at Taibah University during COVID-19 Outbreak. The study focused on two main variables: gender and degree of visual impairment. The sample of the study consisted of 87 undergraduate students with visual impairment enrolled in the academic year 1442 H. The data collection instruments consisted of 35 statements divided into five dimensions: online learning, financial, social, psychological, and physical mobility to examine participants’ challenges. The results of the showed that the challenges faced students with visual impairment are financial, psychological, social, online learning and …

Collaborative Language Planning Project: Report 08: Winter 2023, Richard Littlebear, Mizuki Miyashita, Susan Penfield, Madeleine Shek

Collaborative Language Planning Project: Reports and Newsletters

Collaborative Language Planning Project report of activities, August 2022 - January 2023.

Halloysite Reinforced Natural Esters For Energy Applications, Jaime Taha-Tijerina, Karla Aviña, Victoria Padilla-Gainza, Aditya Akundi

Informatics and Engineering Systems Faculty Publications

Recently, environmentally friendly and sustainable materials are being developed, searching for biocompatible and efficient materials which could be incorporated into diverse industries and fields. Natural esters are investigated and have emerged as eco-friendly high-performance alternatives to mineral fluids. This research shows the evaluations on thermal transport and tribological properties of halloysite nanotubular structures (HNS) reinforcing natural ester lubricant at various filler fractions (0.01, 0.05, and 0.10 wt.%). Nanolubricant tribotestings were evaluated under two configurations, block-on-ring, and 4-balls, to obtain the coefficient of friction (COF) and wear scar diameter (WSD), respectively. Results indicated improvements, even at merely 0.01 wt.% HNS concentration, …

Pulse Oximetry: Why Oxygen Saturation Is Still Not A Part Of Standard Pediatric Guidelines In Low-And-Middle-Income Countries (Lmics), Maheen Sheikh, Huzaifa Ahmad, Romesa Ibrahim, Muhammad Imran Nisar, Fyezah Jehan

Department of Paediatrics and Child Health

Background: With the high frequency of acute respiratory infections in children worldwide, particularly so in low-resource countries, the development of effective diagnostic support is crucial. While pulse oximetry has been found to be an acceptable method of hypoxemia detection, improving clinical decision making and efficient referral, many healthcare set ups in low- and middle-income countries have not been able to implement pulse oximetry into their practice.
Main body: A review of past pulse oximetry implementation attempts in low- and middle-income countries proposes the barriers and potential solutions for complete integration in the healthcare systems. The addition of pulse oximetry into …

Loci On Chromosome 12q132 Encompassing Erbb3, Pa2g4 And Rab5b Are Associated With Polycystic Ovary Syndrome, R Alan Harris, Kellie J Archer, Mark O Goodarzi, Timothy P York, Jeffrey Rogers, Andrea Dunaif, Jan M Mcallister, Jerome F Strauss

Faculty, Staff and Students Publications

Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenemia of ovarian theca cell origin. We report significant association of androgen production with 15 single nucleotide variants (SNVs) identified by exome sequencing of theca cells from women with PCOS and normal ovulatory women. Ten SNVs are located within a 150 kbp region on 12q13.2 which encompasses loci identified in PCOS genome-wide association studies (GWAS) and contains PCOS candidate genes ERBB3 and RAB5B. The region also contains PA2G4 which encodes a transcriptional corepressor of androgen receptor and androgen receptor-regulated genes. PA2G4 has not previously been recognized as related to PCOS in published …

Results Of Surgical Ablation For Atrial Fibrillation In Patients With Rheumatic Heart Disease, Turki B. Albacker, Sultan Alaamro, Abdulaziz M Alhothali, Amr A Arafat, Khaled D Algarni, Ahmed Eldemerdash, Bakir M Bakir

Journal of the Saudi Heart Association

Background There is conflicting evidence regarding the success of the Maze procedure to restore sinus rhythm in patients with rheumatic heart disease. Hence, the aim of our study was to describe the results of surgical ablation for atrial fibrillation in patients with rheumatic heart disease undergoing cardiac surgery. Methods This is a retrospective study that included adult patients with rheumatic heart disease who underwent surgical ablation for atrial fibrillation. The ablation lesions were performed using monopolar radiofrequency ablation in all patients. Results Fifty-seven consecutive patients were included in the study. Cox Maze IV was performed in 44 patients (77%), while …

Dietary Methanolic Extract Of Fenugreek Enhanced The Growth, Haematobiochemical, Immune Responses, And Resistance Against Aeromonas Hydrophila In Nile Tilapia, Oreochromis Niloticus, Amany M. Diab, Basant T. Al-Khefa, Malik M. Khalafallah, Abdallah S. Salah

Faculty Journal Articles

No abstract provided.

Unm Hsc Education Day Agenda 2023, Gary A. Smith

HSC Education Days

No abstract provided.

Digital 3d Brain Mri Arterial Territories Atlas, Chin-Fu Liu, Johnny Hsu, Xin Xu, Ganghyun Kim, Shannon M. Sheppard, Erin L. Meier, Michael I. Miller, Argye E. Hillis, Andreia V. Faria

Communication Sciences and Disorders Faculty Articles and Research

The locus and extent of brain damage in the event of vascular insult can be quantitatively established quickly and easily with vascular atlases. Although highly anticipated by clinicians and clinical researchers, no digital MRI arterial atlas is readily available for automated data analyses. We created a digital arterial territory atlas based on lesion distributions in 1,298 patients with acute stroke. The lesions were manually traced in the diffusion-weighted MRIs, binary stroke masks were mapped to a common space, probability maps of lesions were generated and the boundaries for each arterial territory was defined based on the ratio between probabilistic maps. …

The Onset Of Rare Earth Metallosis Begins With Renal Gadolinium-Rich Nanoparticles From Magnetic Resonance Imaging Contrast Agent Exposure, Joshua Deaguero, Tamara Howard, Donna Kusewitt, Adrian Brearley, Abdul-Mehdi Ali, James H. Degnan, Stephen Jett, John Watt, G Patricia Escobar, Karol Dokladny, Brent Wagner

Pathology Research and Scholarship

The leitmotifs of magnetic resonance imaging (MRI) contrast agent-induced complications range from acute kidney injury, symptoms associated with gadolinium exposure (SAGE)/gadolinium deposition disease, potentially fatal gadolinium encephalopathy, and irreversible systemic fibrosis. Gadolinium is the active ingredient of these contrast agents, a non-physiologic lanthanide metal. The mechanisms of MRI contrast agent-induced diseases are unknown. Mice were treated with a MRI contrast agent. Human kidney tissues from contrast-naïve and MRI contrast agent-treated patients were obtained and analyzed. Kidneys (human and mouse) were assessed with transmission electron microscopy and scanning transmission electron microscopy with X-ray energy-dispersive spectroscopy. MRI contrast agent treatment resulted in …

Adaptation In The Sensory Cortex Drives Bistable Switching During Auditory Stream Segregation, Nathan C. Higgins, Alexandra N. Scurry, Fang Jiang, David F. Little, Mounya Elhilali, Joel S. Snyder

Psychology Faculty Research

Current theories of perception emphasize the role of neural adaptation, inhibitory competition, and noise as key components that lead to switches in perception. Supporting evidence comes from neurophysiological findings of specific neural signatures in modality-specific and supramodal brain areas that appear to be critical to switches in perception. We used functional magnetic resonance imaging to study brain activity around the time of switches in perception while participants listened to a bistable auditory stream segregation stimulus, which can be heard as one integrated stream of tones or two segregated streams of tones. The auditory thalamus showed more activity around the time …

Hmgb1/Gpc3 Dual Targeting Vaccine Induces Dendritic Cells-Mediated Cd8+T Cell Immune Response And Elicits Potential Therapeutic Effect In Hepatocellular Carcinoma, Xiaoqing Shi, Jiage Ding, Yanyan Zheng, Jiawei Wang, Navid Sobhani, Praveen Neeli, Gang Wang, Junnian Zheng, Dafei Chai

Faculty, Staff and Students Publications

Hepatocellular carcinoma (HCC) is a fatal malignant tumor, but effective clinical interventions are limited. PLGA/PEI-mediated DNA vaccine encoding the dual targets of high-mobility group box 1 (HMGB1) or GPC3 was developed for HCC treatment. Compared with PLGA/PEI-GPC3 immunization, PLGA/PEI-HMGB1/GPC3 co-immunization significantly inhibited the subcutaneous tumor growth, while increasing the infiltration of CD8