Digital Commons Network^™

February 10, 2023 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Subjectivizing The Negligence Reasonable Person Standard For Persons With Mental Disabilities, Mackenzie Coupens

Denver Law Review

Hiding under the guise of the fundamental purposes of tort law, the theory of negligence in the United States holds defendants with mental disabilities liable for their actions despite the real possibility that they may be incapable of exercising the required level of care. While individuals with mental disabilities are required to exercise the same level of care as the reasonable, prudent person under the circumstances, the law allows concessions for children and individuals with physical disabilities. For these exceptions, the age and intelligence or physical disability of the defendant are considered part of the circumstances under which the defendant …

[Marked Confidential]: Negative Externalities Of Discovery Secrecy, Gustavo Ribeiro

Denver Law Review

Current unprecedented levels of secrecy in civil discovery create significant negative externalities by preventing our adversary system from measuring up to the broad public goals that justify it. First, excessive discovery secrecy undermines the courts and the public’s ability to correct distortions of the truth-seeking function of the adversary system caused by excessive partisanship and confirmation bias. Second, it weakens the adversary system’s promotion of liberal democratic values, such as transparency and self-government. Third, it threatens the adversary system’s role in upholding human dignity, understood either as respect or status. To correct the negative externalities caused by excessive discovery secrecy, …

Confronting Intellectual Property Nationalism, Cynthia M. Ho

Denver Law Review

Stories about nations engaging in vaccine (and medical) nationalism by hoarding limited COVID-19 vaccines and treatments are widespread, but there is a hidden phenomenon that has exacerbated vaccine nationalism and prolonged the pandemic: intellectual property nationalism or “IP nationalism.” This Article coins and explains this term and highlights its negative impacts. Essentially, some nations, primarily of the Global North, are hoarding essential knowledge protected by intellectual property (IP). This Article argues that IP nationalism has contributed to millions of unnecessary deaths and limited the growth of the global economy. Meanwhile, countries and pharmaceutical companies obscure the role of IP nationalism …

Ud In The News Feb. 4-10, University Of Dayton

News Releases

The Conversation, Associated Press, Eos and Sinclair Broadcasting's The National Desk highlighted UD faculty expertise. Ohio cable news outlet Spectrum News 1 featured McIntosh Scholarship winner Gabby Davis.

A Phase Ib/Ii Study Of Lenvatinib And Pembrolizumab In Advanced Endometrial Carcinoma (Study 111/Keynote-146): Long-Term Efficacy And Safety Update., Vicky Makker, Carol Aghajanian, Allen L Cohn, Margarita Romeo, Raquel Bratos, Marcia S Brose, Mark Messing, Lea Dutta, Corina E Dutcus, Jie Huang, Emmett V Schmidt, Robert Orlowski, Matthew H Taylor

Department of Medicine Faculty Papers

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported.The open-label phase Ib/II Study 111/KEYNOTE-146 of daily lenvatinib 20 mg plus pembrolizumab 200 mg once every 3 weeks showed promising efficacy and tolerable safety in patients with previously treated advanced endometrial carcinoma (EC; primary data cutoff …

Evidence-Based Inventory Of Criminal Justice Programs In Nebraska, Katelynn Towne, Christopher Campbell, Monica Miles-Steffens, Brian Gildea, John Ursino, Ryan E. Spohn, Zachary Hamilton, Michael Campagna, Addison Kobie, Taylor L. Claxton, Laura Dueland, Tara Grell

Reports

This report is the product of collaborative efforts from the Nebraska Center for Justice Research, the School of Criminology and Criminal Justice, Industrial and Organizational Psychology and the Criminology and Criminal Justice department at Portland State University. The purpose of this report is to provide an overview of the importance of using evidence-based practices and programs, examine the quantity and needs addressed by adult criminal justice programs, and provide a snapshot of operating evidence-based programs throughout Nebraska. This report provides findings related to the discovery of programs and a review of branded programs operating in Nebraska. Product 1 – Inventory …

: Changing Education And Workforce Demographics Impacting Nebraska, Josie Gatti Schafer

Presentations

Information on changing education and workforce demographics.

Comparisons Of Small Unmanned Aircraft Systems And Agro-Terrestrial Surveys: Techniques To Determine Field Elevation Surfaces For Improved Crop And Water Management., Richard A. Pickett Jr

Student Theses and Dissertations

Row crop agriculture in Arkansas relies predominantly on groundwater resources for irrigation. This places great demand on the Mississippi River Valley Alluvial Aquifer (MRVAA), which is in a current state of decline. The Eastern Arkansas region produces commodity crops including soybeans, rice, corn, cotton, and peanuts, all of which utilize irrigation for optimal productivity. Conservation practices that reduce groundwater use include precision land leveling, multiple inlet rice irrigation, and computerized hole size selection for furrow irrigation. To collect elevation data to irrigate efficiently, these practices require precision agriculture technology, more specifically Real-Time Kinematic–Global Navigation Satellite Systems (RTK-GNSS). As RTK-GNSS technologies …

Rock Steady Boxing: Addressing Voice Disorders In Individuals With Parkinson's Disease, Andria Mullins

Student Theses and Dissertations

This exploratory study is the first of its kind and was designed to determine if Rock Steady Boxing improves the vocal quality, loudness, and quality of life of individuals with Parkinson’s disease. Individuals in this study participated in the Rock Steady Boxing (RSB) program across a 12-week period. Data collection was completed twice in a pretest/posttest design to determine if there was a significant difference between the variables. The results of this study showed that the entire group (n = 13) was impacted by Rock Steady Boxing classes in terms of intensity and perceptual vocal quality. There was no statistical …

Canadian Maritime Law Jurisdiction Revisited: Quo Vadis?, Aldo Chircop

Dalhousie Law Journal

Maritime jurisdiction in Canada has to contend with the division of powers between the federal and provincial levels. At times, this fact has challenged Canadian courts in explaining what should be the interface between federal and provincial law in dual aspect cases and in determining the applicable law or finding complementary applications of federal and provincial law. This essay reflects on the evolution of maritime law jurisdiction in Canada since the establishment of the Federal Court of Canada in 1971. It discusses the imperative of stability and reality of change in maritime law jurisdiction since then with a focus on …

Variance In Management Of Extracorporeal Membrane Oxygenation-Associated Fibrin Sheaths At A Single Institution, Alexandra Tedesco Md, Monica Majumdar Md, Jamel P. Ortoleva Md, Christine Nayar Md, Masashi Kawabori Md, Payam Salehi Md, Ali Irshad Md

Abington Jefferson Health Papers

Objective: Extracorporeal membrane oxygenation (ECMO) support for patients with cardiac or respiratory failure has been increasingly used by advanced critical care practitioners. The thromboembolic complications of ECMO have been extensively discussed and researched; however, research and discussion on the development, risks, and management of cannulae-associated fibrin sheaths are lacking.

Methods: Institutional review board approval was not required. We have presented three cases detailing the identifi- cation and individualized management of ECMO-associated fibrin sheaths at our institution. The three patients provided written informed consent for the report of their case details and imaging studies.

Results: Of our three patients with ECMO-associated …

Automated Contouring And Planning In Radiation Therapy: What Is 'Clinically Acceptable'?, Hana Baroudi, Kristy K Brock, Wenhua Cao, Xinru Chen, Caroline Chung, Laurence E Court, Mohammad D El Basha, Maguy Farhat, Skylar Gay, Mary P Gronberg, Aashish Chandra Gupta, Soleil Hernandez, Kai Huang, David A Jaffray, Rebecca Lim, Barbara Marquez, Kelly Nealon, Tucker J Netherton, Callistus M Nguyen, Brandon Reber, Dong Joo Rhee, Ramon M Salazar, Mihir D Shanker, Carlos Sjogreen, Mckell Woodland, Jinzhong Yang, Cenji Yu, Yao Zhao

Faculty, Staff and Student Publications

Developers and users of artificial-intelligence-based tools for automatic contouring and treatment planning in radiotherapy are expected to assess clinical acceptability of these tools. However, what is 'clinical acceptability'? Quantitative and qualitative approaches have been used to assess this ill-defined concept, all of which have advantages and disadvantages or limitations. The approach chosen may depend on the goal of the study as well as on available resources. In this paper, we discuss various aspects of 'clinical acceptability' and how they can move us toward a standard for defining clinical acceptability of new autocontouring and planning tools.

With Liberty And Reinsurance For All: The Deep Case For A Government Backstop In Health Care, Christina S. Ho

Denver Law Review

One long-overlooked government function is the provision of reinsurance to insurers and other private entities to help absorb catastrophic costs when losses exceed what those institutions could be expected to bear. Yet the U.S. government fails to reinsure the health plans of ordinary Americans, a step that would shield them from outlier health events. Consider, by contrast, the longstanding federal guarantee to banks and depositors against unusual liquidity risk. The lack of an explicit state-sponsored backstop for health risk is often taken to reflect a national aversion to entitlements. This Article challenges that premise by calling attention to the many …

6th Annual Stonewall Lecture 2-2-2023, Roger Williams University School Of Law

School of Law Conferences, Lectures & Events

No abstract provided.

Evaluation Of Genetic Alterations In Hereditary Cancer Susceptibility Genes In The Ashkenazi Jewish Women Community Of Mexico, Clara Estela Díaz-Velásquez, Rina Gitler, Adriana Antoniano, Ronny Kershenovich Sefchovich, Aldo Hugo De La Cruz-Montoya, Héctor Martínez-Gregorio, Ernesto Arturo Rojas-Jiménez, Ricardo Cortez Cardoso Penha, Luis Ignacio Terrazas, Talia Wegman-Ostrosky, Ephrat Levi-Lahad, Jovanny Zabaleta, Sandra Perdomo, Felipe Vaca-Paniagua

School of Medicine Faculty Publications

Background: Individuals of Ashkenazi Jewish ancestry have been identified as having higher prevalence of specific pathogenic variants associated with susceptibility to specific rare and chronic diseases. In Mexico, the prevalence and composition of rare cancer predisposing germline variants in Ashkenazi Jewish individuals has not been evaluated. Aim and methods: We aimed to evaluate the prevalence of pathogenic variants by massive parallel sequencing in a panel of 143 cancer-predisposing genes in 341 women from the Ashkenazi Jewish community of Mexico, who were contacted and invited to participate in the study through the ALMA Foundation for Cancer Reconstruction. Pre- and posttest genetic …

The Diamond, February 10, 2023, Dordt University

Dordt Diamond

• Front Page: Dordt Students Travel to Capitol Hill for Conference; Theatre Students to Nationals; HLC Accreditation Achieved - ACSI Accreditation Pursued
• News: English Department's Search for New Professor; Battle it out at NC/DC; Capital Campaign Hits the Ground
• Feature: PLIA Trips Over Spring; Mary Returns to the Commons; Into the Jungle - A Boy's Comic Strip History of World War II
• Opinion: The Weekly, or the Weak-ly?; The Pros of Tinder (as a Woman); Advice for the Distant Valentine
• Arts & Entertainment: Student Capstone to Replace Mainstage in February; Broadway and Desserts and NC/DC Collide; …

Challenging Breast Cancer Through Novel Sulfonamide–Pyridine Hybrids: Design, Synthesis, Carbonic Anhydrase Ix Inhibition And Induction Of Apoptosis., Amira Khalil, Nashwa H. Zaher, Reham Mm Elhazek, Ahmed E. Gouda, Marwa G. Elgazzar

Pharmacy

Background: Among the important key modulators of the tumor microenvironment and hypoxia is a family of enzymes named carbonic anhydrases. Herein, 11 novel sulfonamide–pyridine hybrids (2–12) were designed, synthesized and biologically evaluated for their potential use in targeting breast cancer. Methods & results: The para chloro derivative 7 reported the highest cytotoxic activity against the three breast cancer cell lines used. In addition, compound 7 was found to induce cell cycle arrest and autophagy as well as delaying wound healing. The IC50 of compound 7 against carbonic anhydrase IX was 253 ± 12 nM using dorzolamide HCl as control. Conclusion: …

Front Matter

Texas A&M Law Review

Front Matter

“In These Times Of Compassion When Conformity’S In Fashion”: How Therapeutic Jurisprudence Can Root Out Bias, Limit Polarization, And Support Vulnerable Persons In The Legal Process, Michael L. Perlin

Texas A&M Law Review

This Article considers the extent to which caselaw has—either explicitly or implicitly—incorporated the precepts of therapeutic jurisprudence (“TJ”), a school of legal thought that focuses on the law’s influence on emotional life and psychological well-being, and that asks us to assess the actual impact of the law on people’s lives. Two of the core tenets of TJ in practice are commitments to dignity and to compassion. I conclude ultimately that with these principles as touchstones, TJ can be an effective tool—perhaps the most effective tool—in rooting out bias, limiting polarization, and supporting vulnerable persons in the legal process. But this …

My Body, My Choice: Should Physician-Assisted Suicide Be Legalized In The United States For Individuals With Chronic Mental Illness?, Angelika Anderson

Texas A&M Law Review

Many individuals with mental illness wish to die because the symptoms of their illness are unbearable. They shoot, suffocate, and poison themselves to make their pain go away. Because this is a statistical reality, a more certain and less violent means of death should be legalized. This Comment advocates for the legalization of physician-assisted suicide (“PAS”). As of 2022, nine states and the District of Columbia have legalized PAS for terminal illness, but this Comment argues that all fifty states should legalize PAS and not only for terminal illness, but for chronic mental illness as well. To do so, this …

Extinction Or Bust: Improving Species Recovery Under The Endangered Species Act By Amending The Funding Allocation And Recovery Planning Processes, Max Hayashi

Texas A&M Law Review

The Endangered Species Act of 1973 (“ESA”) is among the most powerful environmental statutes passed in U.S. history and serves as a blueprint for government-sanctioned conservation efforts globally. At its core, the ESA seeks to protect listed plant and animal species by prohibiting actions that harm their chances of survival. While the ESA has generally succeeded in pursuing this goal as implemented, it has also led to a host of problems that undermine its effectiveness and generated widespread discontent among conflicting, disparate stakeholders, including environmentalists, industry groups, government agencies, and private landowners. Criticisms of the ESA generally focus on several …

Machine Learning Methods For Computational Phenotyping Using Patient Healthcare Data With Noisy Labels, Praveen Kumar

Computer Science ETDs

Positive and Unlabeled (PU) learning problems abound in many real-world applications. In healthcare informatics, diagnosed patients are considered labeled positive for a specific disease, but being undiagnosed does not mean they can be labeled negative. PU learning can improve classification performance, and estimate the positive fraction, α, among unlabeled samples. However, algorithms based on the Selected Completely At Random (SCAR) assumption are inadequate when the SCAR assumption fails (e.g., severe cases overrepresented), and when class imbalance is substantial. This dissertation presents and evaluates new algorithms to overcome these limitations. The proposed methods outperform the state-of-art for α-estimation, enhance classification performance, …

Greenbug Feeding-Induced Resistance To Sugarcane Aphids In Sorghum, Heena Puri, Edith Ikuze, Jessica Ayala, Isabella Rodriguez, Rupesh Kariyat, Joe Louis, Sajjan Grover

Department of Entomology: Faculty Publications

Plants are attacked by multiple insect pest species and insect herbivory can alter plant defense mechanisms. The plant defense responses to a specific herbivore may also contribute to the herbivore growth/survival on plants. Feeding by one insect species can modulate the plant defenses, which can either facilitate or hamper the colonization of subsequent incoming insects. However, little is known about the effect of sequential herbivory on sorghum plants. In this study, we demonstrate that a specialist aphid, sugarcane aphid (SCA; Melanaphis sacchari) grows faster on sorghum than a generalist aphid species, greenbug (GB; Schizaphis graminum). We also determined …

Moving Beyond Fulfillment: Wisdom Years Stories Of Passion, Perseverance, And Productivity, Kenneth A. Kiewra, Jessica Walsh, Chris Labenz

Department of Educational Psychology: Faculty Publications

Seven participants were interviewed to uncover how they remain so productive in their wisdom years, those typically marked by retirement. Participants included a leading educational psychologist, a renowned national television news anchor, a four-time national champion collegiate coach, the founder and former chief executive of Arbor Day Foundation, a university scholar turned playwright, and two female adventurers who quit their jobs, sold their possessions, and have lived a nomadic life, hiking thousands of miles throughout America. Their wisdom years stories describe how and why they shun retirement and remain productive. The article concludes with seven advice-laden conclusions for readers: (a) …

Dual-Specificity Phosphatases 22-Deficient T Cells Contribute To The Pathogenesis Of Ankylosing Spondylitis, Ming-Han Chen, Huai-Chia Chuang, Yi-Chen Yeh, Chung-Tei Chou, Tse-Hua Tan

Children’s Nutrition Research Center Staff Publications

Background: Dual-specificity phosphatases (DUSPs) can dephosphorylate both tyrosine and serine/threonine residues of their substrates and regulate T cell-mediated immunity and autoimmunity. The aim of this study was to investigate the potential roles of DUSPs in ankylosing spondylitis (AS).

Methods: Sixty AS patients and 45 healthy controls were enrolled in this study. Associations of gene expression of 23 DUSPs in peripheral T cells with inflammatory cytokine gene expression and disease activity of AS were analyzed. Finally, we investigated whether the characteristics of AS are developed in DUSP-knockout mice.

Results: The mRNA levels of DUSP4, DUSP5, DUSP6, DUSP7, and DUSP14 in peripheral …

Small Area Forecasting Of Opioid-Related Mortality: Bayesian Spatiotemporal Dynamic Modeling Approach, Cici Bauer, Kehe Zhang, Wenjun Li, Dana Bernson, Olaf Dammann, Marc R Larochelle, Thomas J Stopka

Faculty, Staff and Student Publications

BACKGROUND: Opioid-related overdose mortality has remained at crisis levels across the United States, increasing 5-fold and worsened during the COVID-19 pandemic. The ability to provide forecasts of opioid-related mortality at granular geographical and temporal scales may help guide preemptive public health responses. Current forecasting models focus on prediction on a large geographical scale, such as states or counties, lacking the spatial granularity that local public health officials desire to guide policy decisions and resource allocation.

OBJECTIVE: The overarching objective of our study was to develop Bayesian spatiotemporal dynamic models to predict opioid-related mortality counts and rates at temporally and geographically …

Clinical Outcomes Of A Large-Scale, Partnership-Based Regional Food Prescription Program: Results Of A Quasi-Experimental Study, Nalini Ranjit, Jennifer N Aiyer, Jack D Toups, Esther Liew, Kenia Way, Henry Shelton Brown, John Wesley Mcwhorter, Shreela V Sharma

Faculty, Staff and Student Publications

BACKGROUND: Food prescription programs are gaining interest from funders, policy makers, and healthcare payers as a way to provide value-based care. A small body of research suggests that such programs effectively impact health outcomes; however, the quality of existing studies is variable, and most studies use small samples. This study attempts to address these gaps by utilizing a quasi-experimental design with non-equivalent controls, to evaluate clinical outcomes among participants enrolled in a food prescription program implemented at scale.

METHODS: We completed a secondary analysis of participant enrollment and utilization data collected between May 2018 and March 2021, by the Houston …

Detecting And Characterizing Suspicious Behaviors Within Youtube Channels, Oluwaseyi David Adeliyi

Theses and Dissertations

Online social networks have been a target of misinformation and manipulative campaigns in recent years. Although, recent literature has been developed to identify individual suspicious accounts that are connected to coordinated manipulative campaigns on platform such as Twitter, there is a need to detect and characterize large-scale coordinated efforts within other contexts. YouTube is the one of the most popular and visited websites in the world and has also been a target of misinformation and online campaigns in recent years, making analysis of suspicious behaviors within the platform vital for the research community and policymakers at large. In this research, …

A Monographic Revision Of The Jewel Scarabs Genus Chrysina From Panama, Colombia, And Ecuador (Coleoptera: Scarabaeidae: Rutelinae: Rutelini), Manuel D. Barria

Zea E-Books Collection

The work is a taxonomic revision of 28 species of the genus Chrysina Kirby (Scarabaeidae: Rutelinae: Rutelini) found in Panama (25), Colombia (2), and Ecuador (3). Chrysina tricolor (Ohaus), Chrysina chalcothea (Bates), and Chrysina cupreomarginata (F. Bates) are new re­cords for Panama. A new country record from northern Colombia is confirmed for Chrys­ina mercedesae Barria. Chrysina gaitalica Curoe and Hawks and Chrysina galbina Hawks are discovered at new localities in Panama; females of both species are discovered and described. Chrysina aurora (Bates) known from other localities in the west of the country, is rediscov­ered in Veraguas province 147 years after …