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Student Nurses' Perception Of Preceptors' Authentic Leadership Effect On Self-Efficacy, Venise D. Bryan Feb 2023

Student Nurses' Perception Of Preceptors' Authentic Leadership Effect On Self-Efficacy, Venise D. Bryan

Dissertations

The study examined the relationship between final year nursing students' perceptions of preceptor authentic leadership and self-efficacy. Nursing students are required to engage in a preceptorship experience at the end of their nursing education for socialisation into the profession and learning consolidation to facilitate optimum transition from student to nurse. Unfortunately, preceptorship has been identified as the most stressful experience that nursing students engage in and poor relations with clinical staff and low competence beliefs to nurse have led to attrition after graduation. To date, a limited number of studies have examined preceptors' leadership style, particularly authentic leadership and student …


Schwalb, Susan, Sophia Maier Garcia Feb 2023

Schwalb, Susan, Sophia Maier Garcia

Bronx Jewish History Project

Susan Schwalb’s father was raised on the Lower East Side to immigrant parents, while her mother grew up on the Grand Concourse in the Bronx. Her mother’s family was German immigrants from the mid-19th century, and owned and operated restaurants. Her grandparents would sell their restaurant and move to Miami, but her uncle owned a famous restaurant in Manhattan that Schwalb would visit as a child. Her mother’s family was wealthy for the time, with extravagant birthday parties that once involved an elephant. Her parents met in the Catskills and Schwalb was born in 1944.

Schwalb grew up in the …


Point/Counterpoint: Transgender Sport Participation Policy, Nafees Alam, Matt Moore Feb 2023

Point/Counterpoint: Transgender Sport Participation Policy, Nafees Alam, Matt Moore

Social Work Faculty Publications

Professor Alam and Professor Moore submitted a Point/Counterpoint commentary article regarding the National Collegiate Athletic Association (NCAA) Board of Governors Transgender Sport Participation Policy


Functional Connectivity Signatures Of Nmdar Dysfunction In Schizophrenia—Integrating Findings From Imaging Genetics And Pharmaco-Fmri, Arnim J Gaebler, Nilüfer Fakour, Felix Stöhr, Jana Zweerings, Arezoo Taebi, Mariia Suslova, Juergen Dukart, Joerg F Hipp, Bhim M Adhikari, Peter Kochunov, Suresh D Muthukumaraswamy, Anna Forsyth, Thomas Eggermann, Florian Kraft, Ingo Kurth, Michael Paulzen, Gerhard Gründer, Frank Schneider, Klaus Mathiak Feb 2023

Functional Connectivity Signatures Of Nmdar Dysfunction In Schizophrenia—Integrating Findings From Imaging Genetics And Pharmaco-Fmri, Arnim J Gaebler, Nilüfer Fakour, Felix Stöhr, Jana Zweerings, Arezoo Taebi, Mariia Suslova, Juergen Dukart, Joerg F Hipp, Bhim M Adhikari, Peter Kochunov, Suresh D Muthukumaraswamy, Anna Forsyth, Thomas Eggermann, Florian Kraft, Ingo Kurth, Michael Paulzen, Gerhard Gründer, Frank Schneider, Klaus Mathiak

Faculty, Staff and Student Publications

Both, pharmacological and genome-wide association studies suggest N-methyl-D-aspartate receptor (NMDAR) dysfunction and excitatory/inhibitory (E/I)-imbalance as a major pathophysiological mechanism of schizophrenia. The identification of shared fMRI brain signatures of genetically and pharmacologically induced NMDAR dysfunction may help to define biomarkers for patient stratification. NMDAR-related genetic and pharmacological effects on functional connectivity were investigated by integrating three different datasets: (A) resting state fMRI data from 146 patients with schizophrenia genotyped for the disease-associated genetic variant rs7191183 of GRIN2A (encoding the NMDAR 2 A subunit) as well as 142 healthy controls. (B) Pharmacological effects of the NMDAR antagonist ketamine and the GABA-A …


A Deep Learning Approach To Identify Missing Is-A Relations In Snomed Ct, Rashmie Abeysinghe, Fengbo Zheng, Elmer V Bernstam, Jay Shi, Olivier Bodenreider, Licong Cui Feb 2023

A Deep Learning Approach To Identify Missing Is-A Relations In Snomed Ct, Rashmie Abeysinghe, Fengbo Zheng, Elmer V Bernstam, Jay Shi, Olivier Bodenreider, Licong Cui

Faculty, Staff and Student Publications

OBJECTIVE: SNOMED CT is the largest clinical terminology worldwide. Quality assurance of SNOMED CT is of utmost importance to ensure that it provides accurate domain knowledge to various SNOMED CT-based applications. In this work, we introduce a deep learning-based approach to uncover missing is-a relations in SNOMED CT.

MATERIALS AND METHODS: Our focus is to identify missing is-a relations between concept-pairs exhibiting a containment pattern (ie, the set of words of one concept being a proper subset of that of the other concept). We use hierarchically related containment concept-pairs as positive instances and hierarchically unrelated containment concept-pairs as negative instances …


Structural Basis Of Impaired Disaggregase Function In The Oxidation-Sensitive Skd3 Mutant Causing 3-Methylglutaconic Aciduria, Jose J Gorbea Colón, Leon Palao, Shin-Fu Chen, Hee Jong Kim, Laura Snyder, Yi-Wei Chang, Kuang-Lei Tsai, Kenji Murakami Feb 2023

Structural Basis Of Impaired Disaggregase Function In The Oxidation-Sensitive Skd3 Mutant Causing 3-Methylglutaconic Aciduria, Jose J Gorbea Colón, Leon Palao, Shin-Fu Chen, Hee Jong Kim, Laura Snyder, Yi-Wei Chang, Kuang-Lei Tsai, Kenji Murakami

Faculty, Staff and Student Publications

Most eukaryotic promoter regions are divergently transcribed. As the RNA polymerase II pre-initiation complex (PIC) is intrinsically asymmetric and responsible for transcription in a single direction, it is unknown how divergent transcription arises. Here, the Saccharomyces cerevisiae Mediator complexed with a PIC (Med-PIC) was assembled on a divergent promoter and analyzed by cryoelectron microscopy. The structure reveals two distinct Med-PICs forming a dimer through the Mediator tail module, induced by a homodimeric activator protein localized near the dimerization interface. The tail dimer is associated with ∼80-bp upstream DNA, such that two flanking core promoter regions are positioned and oriented in …


Genome-Wide Identification, Characterization, And Expression Analysis Of Spiral1 Family Genes In Legume Species, Qianxia Yu, Junjie Liu, Jiayu Jiang, Fudong Liu, Zhen Zhang, Xiaoye Yu, Mengru Li, Intikhab Alam, Liangfa Ge Feb 2023

Genome-Wide Identification, Characterization, And Expression Analysis Of Spiral1 Family Genes In Legume Species, Qianxia Yu, Junjie Liu, Jiayu Jiang, Fudong Liu, Zhen Zhang, Xiaoye Yu, Mengru Li, Intikhab Alam, Liangfa Ge

Faculty, Staff and Student Publications

The SPIRAL1 (SPR1) gene family encodes microtubule-associated proteins that are essential for the anisotropic growth of plant cells and abiotic stress resistance. Currently, little is known about the characteristics and roles of the gene family outside of Arabidopsis thaliana. This study intended to investigate the SPR1 gene family in legumes. In contrast to that of A. thaliana, the gene family has undergone shrinking in the model legume species Medicago truncatula and Glycine max. While the orthologues of SPR1 were lost, very few SPR1-Like (SP1L) genes were identified given the genome size of the two …


Using Artificial Intelligence To Improve Pain Assessment And Pain Management: A Scoping Review, Meina Zhang, Linzee Zhu, Shih-Yin Lin, Keela Herr, Chih-Lin Chi, Ibrahim Demir, Karen Dunn Lopez, Nai-Ching Chi Feb 2023

Using Artificial Intelligence To Improve Pain Assessment And Pain Management: A Scoping Review, Meina Zhang, Linzee Zhu, Shih-Yin Lin, Keela Herr, Chih-Lin Chi, Ibrahim Demir, Karen Dunn Lopez, Nai-Ching Chi

Faculty, Staff and Student Publications

CONTEXT: Over 20% of US adults report they experience pain on most days or every day. Uncontrolled pain has led to increased healthcare utilization, hospitalization, emergency visits, and financial burden. Recognizing, assessing, understanding, and treating pain using artificial intelligence (AI) approaches may improve patient outcomes and healthcare resource utilization. A comprehensive synthesis of the current use and outcomes of AI-based interventions focused on pain assessment and management will guide the development of future research.

OBJECTIVES: This review aims to investigate the state of the research on AI-based interventions designed to improve pain assessment and management for adult patients. We also …


February 16, 2023, The Daily Mississippian Feb 2023

February 16, 2023, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.


February 16, 2023, James Madison University Feb 2023

February 16, 2023, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.


Parp1 Associates With R-Loops To Promote Their Resolution And Genome Stability, Natalie Laspata, Parminder Kaur, Sofiane Yacine Mersaoui, Daniela Muoio, Zhiyan Silvia Liu, Maxwell Henry Bannister, Hai Dang Nguyen, Caroline Curry, John M. Pascal, Guy G. Poirier, Hong Wang, Jean-Yves Masson, Elise Fouquerel Feb 2023

Parp1 Associates With R-Loops To Promote Their Resolution And Genome Stability, Natalie Laspata, Parminder Kaur, Sofiane Yacine Mersaoui, Daniela Muoio, Zhiyan Silvia Liu, Maxwell Henry Bannister, Hai Dang Nguyen, Caroline Curry, John M. Pascal, Guy G. Poirier, Hong Wang, Jean-Yves Masson, Elise Fouquerel

Student Papers, Posters & Projects

PARP1 is a DNA-dependent ADP-Ribose transferase with ADP-ribosylation activity that is triggered by DNA breaks and non-B DNA structures to mediate their resolution. PARP1 was also recently identified as a component of the R-loop-associated protein-protein interaction network, suggesting a potential role for PARP1 in resolving this structure. R-loops are three-stranded nucleic acid structures that consist of a RNA-DNA hybrid and a displaced non-template DNA strand. R-loops are involved in crucial physiological processes but can also be a source of genome instability if persistently unresolved. In this study, we demonstrate that PARP1 binds R-loops in vitro and associates with R-loop formation …


The Student Movement Volume 107 Issue 16: Soul Lounge, Self-Care, And Stripple Breakfast Burritos: There's Something For Everyone, Solana Campbell, Gloria Oh, Caryn Cruz, Terika Williams, Skyler Campbell, Marcel Mattox, Andrew Francis, Katie Davis, Alexander J. Hess, Abby Shim, Reagan Mccain, Abraham Bravo, Lily Burke Feb 2023

The Student Movement Volume 107 Issue 16: Soul Lounge, Self-Care, And Stripple Breakfast Burritos: There's Something For Everyone, Solana Campbell, Gloria Oh, Caryn Cruz, Terika Williams, Skyler Campbell, Marcel Mattox, Andrew Francis, Katie Davis, Alexander J. Hess, Abby Shim, Reagan Mccain, Abraham Bravo, Lily Burke

The Student Movement v. 107 (2022-2023)

HUMANS

AU's Favorite Classes, Solana Campbell

Becoming Multilingual, Gloria Oh

Greatest Gazebo Orders, Solana Campbell

Interview with VP Nixon, Caryn Cruz

ARTS & ENTERTAINMENT

Currently: Babel, Terika Williams

That 90's Love: BSCF Soul Lounge, Skyler Campbell

The Therapist, Marcel Mattox

NEWS

Experience Andrews University's Community Adult Education, Gloria Oh

Joyful Resilience: An Art Experience at AU, Solana Campbell

Students Share Their African Heritage at Short Course, Andrew Francis

IDEAS

The Future of Self-Care, Katie Davis

The Straw that Breaks the Camel's Back? Beyoncé and the 2023 Grammys, Alexander J. Hess

Death Toll Passes 41,000: Turkey and Syria Earthquakes, Abby Shim …


Vista: February 16, 2023, University Of San Diego Feb 2023

Vista: February 16, 2023, University Of San Diego

USD Vista (1965-)

No abstract provided.


Montana Kaimin, February 16, 2023, Students Of The University Of Montana, Missoula Feb 2023

Montana Kaimin, February 16, 2023, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.


The George-Anne Daily, Georgia Southern University Feb 2023

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.


‘How Are You Doing?’: College Instructors’ Relationships And Communication With Students With Intellectual Disabilities, Gavin W. Watts, Mariya T. Davis, Eric J. Lopez Feb 2023

‘How Are You Doing?’: College Instructors’ Relationships And Communication With Students With Intellectual Disabilities, Gavin W. Watts, Mariya T. Davis, Eric J. Lopez

Special Education Faculty Publications (Archived)

The Higher Education Opportunity Act has increased the number of postsecondary education programs established to assist individuals with intellectual disabilities (ID) in attending college. With the development of these new programs, there is an ever-present need to assess the interactions and necessary strategies to support students with ID in higher education. As college instructors are the primary instructors within these settings and programs, the current study explored this population’s perceptions and experiences related to instructing, communicating, and developing effective relationships with students with ID in their coursework. In-depth interviews were conducted with six college instructors working with students with ID …


Gloria - A Globally Representative Hyperspectral In Situ Dataset For Optical Sensing Of Water Quality, Moritz K. Lehmann, Daniela Gurlin, Nima Pahlevan, Krista Alikas, Janet Anstee, Sundarabalan V. Balasubramanian, Cláudio C.F. Barbosa, Caren Binding, Astrid Bracher, Mariano Bresciani, Ashley Burtner, Zhigang Cao, Arnold G. Dekker, Courtney Di Vittorio, Nathan Drayson, Reagan M. Errera, Virginia Fernandez, Dariusz Ficek, Cédric G. Fichot, Peter Gege, Claudia Giardino, Anatoly A. Gitelson, Steven R. Greb, Hayden Henderson, Hiroto Higa, Abolfazl Irani Rahaghi, Cédric Jamet, Dalin Jiang, Thomas Jordan, Kersti Kangro, Jeremy A. Kravitz Feb 2023

Gloria - A Globally Representative Hyperspectral In Situ Dataset For Optical Sensing Of Water Quality, Moritz K. Lehmann, Daniela Gurlin, Nima Pahlevan, Krista Alikas, Janet Anstee, Sundarabalan V. Balasubramanian, Cláudio C.F. Barbosa, Caren Binding, Astrid Bracher, Mariano Bresciani, Ashley Burtner, Zhigang Cao, Arnold G. Dekker, Courtney Di Vittorio, Nathan Drayson, Reagan M. Errera, Virginia Fernandez, Dariusz Ficek, Cédric G. Fichot, Peter Gege, Claudia Giardino, Anatoly A. Gitelson, Steven R. Greb, Hayden Henderson, Hiroto Higa, Abolfazl Irani Rahaghi, Cédric Jamet, Dalin Jiang, Thomas Jordan, Kersti Kangro, Jeremy A. Kravitz

Michigan Tech Publications, Part 1

The development of algorithms for remote sensing of water quality (RSWQ) requires a large amount of in situ data to account for the bio-geo-optical diversity of inland and coastal waters. The GLObal Reflectance community dataset for Imaging and optical sensing of Aquatic environments (GLORIA) includes 7,572 curated hyperspectral remote sensing reflectance measurements at 1 nm intervals within the 350 to 900 nm wavelength range. In addition, at least one co-located water quality measurement of chlorophyll a, total suspended solids, absorption by dissolved substances, and Secchi depth, is provided. The data were contributed by researchers affiliated with 59 institutions worldwide and …


Food Safety Practices - Slides From 02-14-2023 Webinar, Wendy Johnecheck Feb 2023

Food Safety Practices - Slides From 02-14-2023 Webinar, Wendy Johnecheck

UNH Cooperative Extension

No abstract provided.


Diagnosing And Treating Infertility Via Transvaginal Natural Orifice Transluminal Endoscopic Surgery Versus Laparoendoscopic Single-Site Surgery: A Retrospective Study, Yanli Zhang, Yiping Zhu, Mengsong Sui, Xiaoming Guan, Jing Sun Feb 2023

Diagnosing And Treating Infertility Via Transvaginal Natural Orifice Transluminal Endoscopic Surgery Versus Laparoendoscopic Single-Site Surgery: A Retrospective Study, Yanli Zhang, Yiping Zhu, Mengsong Sui, Xiaoming Guan, Jing Sun

Faculty, Staff and Students Publications

OBJECTIVE: To evaluate the efficacy and safety of transvaginal natural orifice transluminal endoscopic surgery (vNOTES) in the treatment of female infertility.

MATERIALS AND METHODS: This study includes 174 female patients with a history of long-standing female infertility. We retrospectively reviewed 41 patients who underwent hysterolaparoscopy (HL) via transvaginal natural orifice transluminal endoscopic surgery (vNOTES) and 133 patients who underwent laparoendoscopic single-site surgery (LESS). Demographic data, operation records, and pregnancy outcomes were collected and analyzed. The deadline for postoperative follow-up was June 2022. All the included patients were followed up for at least 18 months after surgery.

RESULTS: Compared with the …


A Human Stem Cell-Derived Neuronal Model Of Morphine Exposure Reflects Brain Dysregulation In Opioid Use Disorder: Transcriptomic And Epigenetic Characterization Of Postmortem-Derived Ipsc Neurons, Emily F Mendez, Sandra L Grimm, Laura Stertz, Damian Gorski, Sai V Movva, Katherine Najera, Karla Moriel, Thomas D Meyer, Gabriel R Fries, Cristian Coarfa, Consuelo Walss-Bass Feb 2023

A Human Stem Cell-Derived Neuronal Model Of Morphine Exposure Reflects Brain Dysregulation In Opioid Use Disorder: Transcriptomic And Epigenetic Characterization Of Postmortem-Derived Ipsc Neurons, Emily F Mendez, Sandra L Grimm, Laura Stertz, Damian Gorski, Sai V Movva, Katherine Najera, Karla Moriel, Thomas D Meyer, Gabriel R Fries, Cristian Coarfa, Consuelo Walss-Bass

Faculty, Staff and Student Publications

INTRODUCTION: Human-derived induced pluripotent stem cell (iPSC) models of brain promise to advance our understanding of neurotoxic consequences of drug use. However, how well these models recapitulate the actual genomic landscape and cell function, as well as the drug-induced alterations, remains to be established. New

METHODS: We engineered a novel induced pluripotent stem cell-derived model of neural progenitor cells and neurons from cultured postmortem human skin fibroblasts, and directly compared these to isogenic brain tissue from the donor source. We assessed the maturity of the cell models across differentiation from stem cells to neurons using RNA cell type and maturity …


Optimized Workplace Risk Mitigation Measures For Sars-Cov-2 In 2022, Rowland Pettit, Bo Peng, Patrick Yu, Peter G Matos, Alexander L Greninger, Julie Mccashin, Christopher Ian Amos Feb 2023

Optimized Workplace Risk Mitigation Measures For Sars-Cov-2 In 2022, Rowland Pettit, Bo Peng, Patrick Yu, Peter G Matos, Alexander L Greninger, Julie Mccashin, Christopher Ian Amos

Faculty, Staff and Students Publications

596 million SARS-CoV-2 cases have been reported and over 12 billion vaccine doses have been administered. As vaccination rates increase, a gap in knowledge exists regarding appropriate thresholds for escalation and de-escalation of workplace COVID-19 preventative measures. We conducted 133,056 simulation experiments, evaluating the spread of SARS-CoV-2 virus in hypothesized working environments subject to COVID-19 infections from the community. We tested the rates of workplace-acquired infections based on applied isolation strategies, community infection rates, methods and scales of testing, non-pharmaceutical interventions, variant predominance, vaccination coverages, and vaccination efficacies. When 75% of a workforce is vaccinated with a 70% efficacious vaccine …


Draft Final 2023 Residential Metals Abatement Program (Rmap) Walkerville Park (Alley Of North Main And Alley Of West Daly) Soil Remedial Action Work Plan (Rawp), Pioneer Technical Services, Inc. Feb 2023

Draft Final 2023 Residential Metals Abatement Program (Rmap) Walkerville Park (Alley Of North Main And Alley Of West Daly) Soil Remedial Action Work Plan (Rawp), Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


2022 Stormwater Bmps Repair, Inspection Report, And Maintenance Work Plan Bnsf Railway Company And Union Pacific Railroad Company Butte Priority Soils Operable Unit Kj 2299019.00, Doug Brannan P.E., Kennedy Jenks Feb 2023

2022 Stormwater Bmps Repair, Inspection Report, And Maintenance Work Plan Bnsf Railway Company And Union Pacific Railroad Company Butte Priority Soils Operable Unit Kj 2299019.00, Doug Brannan P.E., Kennedy Jenks

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Evaluation Of Bnt162b2 Covid-19 Vaccine In Children Younger Than 5 Years Of Age, Flor M Muñoz, Lawrence D Sher, Charu Sabharwal, Alejandra Gurtman, Xia Xu, Nicholas Kitchin, Stephen Lockhart, Robert Riesenberg, Joanna M Sexter, Hanna Czajka, Grant C Paulsen, Yvonne Maldonado, Emmanuel B Walter, Kawsar R Talaat, Janet A Englund, Uzma N Sarwar, Caitlin Hansen, Martha Iwamoto, Chris Webber, Luke Cunliffe, Benita Ukkonen, Silvina N Martínez, Barbara A Pahud, Iona Munjal, Joseph B Domachowske, Kena A Swanson, Hua Ma, Kenneth Koury, Susan Mather, Claire Lu, Jing Zou, Xuping Xie, Pei-Yong Shi, David Cooper, Özlem Türeci, Uğur Şahin, Kathrin U Jansen, William C Gruber, C4591007 Clinical Trial Group Feb 2023

Evaluation Of Bnt162b2 Covid-19 Vaccine In Children Younger Than 5 Years Of Age, Flor M Muñoz, Lawrence D Sher, Charu Sabharwal, Alejandra Gurtman, Xia Xu, Nicholas Kitchin, Stephen Lockhart, Robert Riesenberg, Joanna M Sexter, Hanna Czajka, Grant C Paulsen, Yvonne Maldonado, Emmanuel B Walter, Kawsar R Talaat, Janet A Englund, Uzma N Sarwar, Caitlin Hansen, Martha Iwamoto, Chris Webber, Luke Cunliffe, Benita Ukkonen, Silvina N Martínez, Barbara A Pahud, Iona Munjal, Joseph B Domachowske, Kena A Swanson, Hua Ma, Kenneth Koury, Susan Mather, Claire Lu, Jing Zou, Xuping Xie, Pei-Yong Shi, David Cooper, Özlem Türeci, Uğur Şahin, Kathrin U Jansen, William C Gruber, C4591007 Clinical Trial Group

Faculty, Staff and Students Publications

BACKGROUND: Safe and effective vaccines against coronavirus disease 2019 (Covid-19) are urgently needed in young children.

METHODS: We conducted a phase 1 dose-finding study and are conducting an ongoing phase 2-3 safety, immunogenicity, and efficacy trial of the BNT162b2 vaccine in healthy children 6 months to 11 years of age. We present results for children 6 months to less than 2 years of age and those 2 to 4 years of age through the data-cutoff dates (April 29, 2022, for safety and immunogenicity and June 17, 2022, for efficacy). In the phase 2-3 trial, participants were randomly assigned (in a …


Emergent Dynamics Of Adult Stem Cell Lineages From Single Nucleus And Single Cell Rna-Seq Of Drosophila Testes, Amelie A Raz, Gabriela S Vida, Sarah R Stern, Sharvani Mahadevaraju, Jaclyn M Fingerhut, Jennifer M Viveiros, Soumitra Pal, Jasmine R Grey, Mara R Grace, Cameron W Berry, Hongjie Li, Jasper Janssens, Wouter Saelens, Zhantao Shao, Chun Hu, Yukiko M Yamashita, Teresa Przytycka, Brian Oliver, Julie A Brill, Henry Krause, Erika L Matunis, Helen White-Cooper, Stephen Dinardo, Margaret T Fuller Feb 2023

Emergent Dynamics Of Adult Stem Cell Lineages From Single Nucleus And Single Cell Rna-Seq Of Drosophila Testes, Amelie A Raz, Gabriela S Vida, Sarah R Stern, Sharvani Mahadevaraju, Jaclyn M Fingerhut, Jennifer M Viveiros, Soumitra Pal, Jasmine R Grey, Mara R Grace, Cameron W Berry, Hongjie Li, Jasper Janssens, Wouter Saelens, Zhantao Shao, Chun Hu, Yukiko M Yamashita, Teresa Przytycka, Brian Oliver, Julie A Brill, Henry Krause, Erika L Matunis, Helen White-Cooper, Stephen Dinardo, Margaret T Fuller

Faculty, Staff and Students Publications

Proper differentiation of sperm from germline stem cells, essential for production of the next generation, requires dramatic changes in gene expression that drive remodeling of almost all cellular components, from chromatin to organelles to cell shape itself. Here, we provide a single nucleus and single cell RNA-seq resource covering all of spermatogenesis in Drosophila starting from in-depth analysis of adult testis single nucleus RNA-seq (snRNA-seq) data from the Fly Cell Atlas (FCA) study. With over 44,000 nuclei and 6000 cells analyzed, the data provide identification of rare cell types, mapping of intermediate steps in differentiation, and the potential to identify …


Introducing Second-Year Medical Students To Diagnostic Reasoning Concepts And Skills Via A Virtual Curriculum, Chelsea Chang, Nevin A. Varghese, Michael Machiorlatti Feb 2023

Introducing Second-Year Medical Students To Diagnostic Reasoning Concepts And Skills Via A Virtual Curriculum, Chelsea Chang, Nevin A. Varghese, Michael Machiorlatti

School of Medicine Publications

Objectives

Curriculum for clinical reasoning in the preclinical years is sparse and the COVID-19 pandemic heightened the need for virtual curriculums.

Methods

We developed, implemented and evaluated a virtual curriculum for preclinical students scaffolding key diagnostic reasoning concepts: dual process theory, diagnostic error, problem representation and illness scripts. Fifty-five second-year medical students participated in four 45-min virtual sessions led by one facilitator.

Results

The curriculum led to increased perceived understanding and increased confidence in diagnostic reasoning concepts and skills.

Conclusions

The virtual curriculum was effective in introducing diagnostic reasoning and was well-received by second-year medical students.


Pilot Testing For Feasibility Of Role Of Public Libraries In Citizenship Information, Vanita Khanchandani Feb 2023

Pilot Testing For Feasibility Of Role Of Public Libraries In Citizenship Information, Vanita Khanchandani

Library Philosophy and Practice (e-journal)

This paper outlines the significance of the pilot study in determining the feasibility of the main study, i.e., the role of the public libraries in citizenship information, and entails pre-testing the measuring tool (questionnaire). In the pilot study, 25 items were assessed on 27 subjects, and internal reliability was determined using Cronbach’s Alpha. The Alpha was found to be 0.78, indicating acceptable consistency of the measuring tool. (questionnaire). This pilot study will be beneficial in determining how to administer the measuring instrument for conducting the actual study and will bring transparency to the research process. The study will embark …


Hallmarks Of Neurodegenerative Diseases, David M Wilson 3rd, Mark R Cookson, Ludo Van Den Bosch, Henrik Zetterberg, David M Holtzman, Ilse Dewachter Feb 2023

Hallmarks Of Neurodegenerative Diseases, David M Wilson 3rd, Mark R Cookson, Ludo Van Den Bosch, Henrik Zetterberg, David M Holtzman, Ilse Dewachter

2020-Current year OA Pubs

Decades of research have identified genetic factors and biochemical pathways involved in neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks of NDD: pathological protein aggregation, synaptic and neuronal network dysfunction, aberrant proteostasis, cytoskeletal abnormalities, altered energy homeostasis, DNA and RNA defects, inflammation, and neuronal cell death. We describe the hallmarks, their biomarkers, and their interactions as a framework to study NDDs using a holistic approach. The framework can serve as a basis for defining pathogenic mechanisms, categorizing different NDDs based on their primary hallmarks, stratifying patients within a specific NDD, and designing multi-targeted, personalized therapies to effectively …


Cool-Clave – An Energy Efficient Autoclave, Indraneel R. Chowdhury, John Summerscales Feb 2023

Cool-Clave – An Energy Efficient Autoclave, Indraneel R. Chowdhury, John Summerscales

School of Engineering, Computing and Mathematics

Out-of-autoclave (OOA) manufacturing techniques for composites result in 7 lower fibre volume fractions than for fully compressed laminates. The lower fibre volume 8 fraction produces a higher resin volume fraction which becomes resin-rich volumes (RRV) 9 [1]. Textile reinforcements with clustered fibres and consequent RRV generally have low 10 strength but high in-plane process permeability, whereas the opposite is true for uni-11 formly distributed fibres [1, 2]. The inevitable increase in resin volume fraction of OOA 12 composites often compromises composite performance and leads to relatively higher 13 weight and fuel consumption in transport applications. Retention of autoclave processing 14 …


Conjugated Linoleic Acid Content Of Milk From Cows Fed Different Diets, E. Staszak, J. Mikołajczak Feb 2023

Conjugated Linoleic Acid Content Of Milk From Cows Fed Different Diets, E. Staszak, J. Mikołajczak

IGC Proceedings (1977-2023)

Conjugated linoleic acid (CLA) is a mixture of positional and geometric isomers of linoleic acid (c-9, c-12 C18:2). Conjugated linoleic acid occurs naturally in foods, however the main dietary sources are dairy products and other foods derived from ruminants. Continuous interest in CLA is attributed to its potential health benefits such as anticarcinogenic, antiatherogenic, antidiabetic and antiadipogenic effects (Dhiman et al., 1999, Staszak et al., 2001). Typical consumption of CLA by humans is far lower than the dose that has been shown to be effective in reducing tumours in animal models (Dhiman et al., 1999), …