Digital Commons Network^™

Molecular Diagnostics In The Evaluation Of Thyroid Nodules: Current Use And Prospective Opportunities, Jena Patel, Joshua Klopper, Elizabeth E. Cottrill

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

Thyroid cancer is the most common endocrine malignancy with an estimated 43,800 new cases to be diagnosed in 2022 and representing the 7th most common cancer in women. While thyroid nodules are very common, being identified in over 60% of randomly selected adults, only 5-15% of thyroid nodules harbor thyroid malignancy. Therefore, it is incumbent upon physicians to detect and treat thyroid malignancies as is clinically appropriate and avoid unnecessary invasive procedures in patients with benign asymptomatic lesions. Over the last 15-20 years, rapid advances have been made in cytomolecular testing to aid in thyroid nodule management. Initially, indeterminate thyroid …

An Interactive Multisource De&I Dashboard At The Program & Sponsoring Institution Levels – A Snapshot, Kathryn Agard, Tricia La Fratta, Deborah Simpson, Aboud Affi, Mohammad Mortada, Wilhelm Lehmann, Willilam Macdonald, Jacob Bidwell

Aurora GME

Background: Recent literature emphases that Diversity, Equity, & Inclusion (DE&I) efforts be data driven and transparent, often in dashboard format, to support the ability of GME programs and sponsoring institutions (SI) to clearly identify progress and concerns longitudinally. DE&I efforts have been a long-term focus in our GME programs and SI and are now further delineated in the ACGME's Common Program Requirements scheduled to take effect July 1, 2023. However, DE&I data sources may be limited, challenging to collect and/or in variable formats from multiple sources making it difficult to capture a longitudinal view of our efforts by program/SI.

Objectives: …

Volume Cxlii, Number 15, February 24, 2023, Lawrence University

The Lawrentian

No abstract provided.

Doc 2023-03 University Professional Faculty Promotion Policy, University Of Dayton. Faculty Affairs Committee

Senate Documents

ACTION: Legislative Authority
/="/">
/="/">Proposal to ensure all full-time faculty have a pathway from promotion. This policy establishes general guidelines that govern University-wide procedures for promotion of full-time faculty who are not governed by the University Promotion and Tenure Policy, are not part of the School of Law, and who do not hold a visiting position.

Monitoring Resistance And Biochemical Studies Of Three Egyptian Field Strains Of Spodoptera Littoralis (Lepidoptera: Noctuidae) To Six Insecticides, Moataz A M Moustafa, Rasha I A Moteleb, Yehia F Ghoneim, Sameh Sh Hafez, Reham E Ali, Essam E A Eweis, Nancy N Hassan

Faculty, Staff and Student Publications

BACKGROUND:

METHODS: Laboratory bioassays were carried out using the leaf-dipping method to examine the susceptibility of the laboratory and field strains to the tested insecticides. Activities of detoxification enzymes were determined in an attempt to identify resistance mechanisms.

RESULTS: The results showed that LC

CONCLUSION: Our findings, along with other tactics, are expected to help with the resistance management of

Maternal Gestational Diabetes Is Associated With High Risk Of Childhood Overweight And Obesity: A Cross-Sectional Study In Pre-School Children Aged 2–5 Years, Maria Mantzorou, Dimitrios Papandreou, Eleni Pavlidou, Sousana K. Papadopoulou, Maria Tolia, Maria Mentzelou, Antigoni Poutsidi, Georgios Antasouras, Georgios K. Vasios, Constantinos Giaginis

All Works

Background and Objectives: Childhood obesity is a global public health concern with long-term and serious health implications. An important factor for childhood obesity is maternal gestational diabetes mellitus (GDM), which in turn impacts maternal and offspring long-term health. This study aimed to investigate the associations between maternal GDM and childhood weight status and multiple anthropometric and sociodemographic factors and perinatal outcomes. Materials and Methods: A total of 5348 children aged 2–5 years old and their paired mothers took part in the study. Questionnaires were utilized to evaluate the sociodemographic factors and perinatal outcomes as well as smoking habits, educational level, …

Sperm Donor Attitudes And Experiences With Direct-To-Consumer Genetic Testing., Sascha Wodoslawsky, Joy Fatunbi, Rebecca Mercier, Andrea Mechanick Braverman

Department of Obstetrics and Gynecology Faculty Papers

OBJECTIVE: To identify factors influencing sperm donor willingness to participate in direct-to-consumer genetic testing, comfort with sharing genetically identifiable data in commercial genetic testing databases, and likelihood to donate sperm again.

DESIGN: Cross-sectional online anonymous survey.

SETTING: Multicenter, 2 large American sperm banks from July 1, 2020 to July10, 2021.

PATIENTS: Sperm donors from 1980 to 2020.

INTERVENTIONS: None.

MAIN OUTCOME MEASURES: Associations between donor demographic characteristics, donation history, and attitudes toward direct-to-consumer genetic testing.

RESULTS: A total of 396 donors completed the survey. Most donations (61.5%) occurred from 2010 to 2020, and 34.3% were nonidentified donations. Nonidentified donors were …

Medicaid Transition Small Stakeholder Meeting, Lucy C. Hodder, Deborah Fournier, Molly Umana

All Materials

No abstract provided.

New Synthetic Opioids: Clinical Considerations And Dangers, Amber N. Edinoff, David Martinez Garza, Stephen P. Vining, Megan E. Vasterling, Eric D. Jackson, Kevin S. Murnane, Adam M. Kaye, Richard N. Fair, Yair Jose Lopez Torres, Ahmed E. Badr, Elyse M. Cornett, Alan D. Kaye

Pacific Faculty Work

Since the early 2010s, synthetic opioids have significantly contributed to overall opioid-related overdose mortalities. For point of reference, of the 68,630 opioid-related deaths recorded in 2020, 56,516 involved synthetic opioids. During much of this period, fentanyl has been the most commonly used synthetic opioid. This time when fentanyl was the most popular opioid has been called the “third wave” of the opioid crisis, partly because it led to a sharp rise in deaths from overdoses. Other synthetic opioids, such as carfentanil, protonitazene, and isotonitazene, have also become more widely diverted for nonmedical used. Carfentanil is an even more potent fentanyl …

Monitoring Forest Edges—Gateways To Our Woodlands, Nicholas Gosling

UNH Today Archive

No abstract provided.

Role Of Ribosome Recycling Factor In Natural Termination And Translational Coupling As A Ribosome Releasing Factor, Yoshio Inokuchi, Fabio Quaglia, Akikazu Hirashima, Yoshihiro Yamamoto, Hideko Kaji, Akira Kaji

Department of Biochemistry and Molecular Biology Faculty Papers

The role of ribosome recycling factor (RRF) of E. coli was studied in vivo and in vitro. We used the translational coupling without the Shine-Dalgarno sequence of downstream ORF (d-ORF) as a model system of the RRF action in natural termination of protein synthesis. For the in vivo studies we used the translational coupling by the adjacent coat and lysis genes of RNA phage GA sharing the termination and initiation (UAAUG) and temperature sensitive RRF. The d-ORF translation was measured by the expression of the reporter lacZ gene connected to the 5'-terminal part of the lysis gene. The results showed …

Fostering Responsible Innovation In Fintech, Willie Almack

Loyola of Los Angeles Law Review

The California Consumer Financial Protection Law (CCFPL) was passed in 2020. This piece of legislation rebranded the state’s financial services regulator as the “Department of Financial Protection and Innovation” (DFPI) and authorized the creation of an “Office of Financial Technology Innovation” (OFTI) within the DFPI. The CCFPL grants the DFPI expanded supervision over “fintech” providers—firms that leverage software-based technologies to deliver financial services to consumers via nontraditional conduits. Recognizing that fintech presents both potential benefits and risks for consumers, the California legislature took measures to ensure that the new regulatory scheme does not stifle innovation. Using the DFPI as a …

"Judicial Frustration": A Local Judge's Bold Attempt To Solve The Homelessness Crisis From The Bench, Gregory A. Alonge

Loyola of Los Angeles Law Review

In May 2021, in the case of LA Alliance v. Los Angeles, Judge David O. Carter of the Central District of California granted a sweeping order enjoining the city and county of Los Angeles to offer shelter to all unhoused persons living in Skid Row. The 109-page order identified structural racism and government indifference as the unconstitutional causes of homelessness in the region, and condemned California’s housing-first approach to addressing the issue. Although the Ninth Circuit swiftly vacated the preliminary injunction on procedural grounds, Judge Carter’s order begs the question: would universal shelter offers actually ameliorate the homelessness crisis? …

Maine Update: Mills Remains Popular Governor; Majorities Favor Voter Id & Family Leave Bills 2/24/2023, Unh Survey Center

All UNH Survey Center Polls

A majority of Mainers continue to approve of Janet Mills’ performance as Maine's Governor and she remains personally popular in the state. Majorities of Mainers support voter identification and family leave bills, as well as a bill which would allow abortion after 24 weeks if approved by a doctor. Most Mainers consider homelessness to be a serious problem in the state and the cost of living and housing are most often mentioned as the most important problems facing Maine.

Gathered Together: The Impact Of In-Person Experiences In A Virtual Age, Consuela Knox

DMin Project Theses

This February 2024 Doctor of Ministry project thesis at Lipscomb University analyzes how following the height of a global health pandemic which required that individuals quarantine, in-person attendance at West Harpeth Church worship services has not reached the pre-pandemic level. The goal of this project was to enhance West Harpeth members’ theological understanding of the importance of in-person corporate gatherings as compared to virtual gatherings. The key research question was: Can awareness of the value of in-person corporate gatherings at West Harpeth, in comparison to virtual gatherings, be raised among members by them engaging in theological reflection? Related questions were: …

Sga 54 Senate 2023-02-24 Minutes, Niu Student Government Association Senate

Student Government Association Archives

No abstract provided.

Introduction: Varieties Of Recognition, Samuel H. Pillsbury

Loyola of Los Angeles Law Review

No abstract provided.

Festschrift Symposium: Honoring Professor Samuel Pillsbury, Guyora Binder, Samantha Buckingham, Deborah W. Denno, Kevin Lapp, Mary Graw Leary, Stephen J. Morse, John T. Nockleby, Samuel H. Pillsbury, Michael Waterstone, Gary C. Williams, Scott Wood

Loyola of Los Angeles Law Review

The Loyola of Los Angeles Law Review is pleased to publish this Festschrift Symposium Honoring Professor Samuel Pillsbury. The following is an edited transcript of the live symposium held at LMU Loyola Law School on Friday, March 25, 2022.

Overprotected But Unrepresented: An Argument For Mandatory Appointment Of Counsel And Against Automatic General Conservatorships In California, Maria De Los Angeles Reyes Olmedo

Loyola of Los Angeles Law Review

Conservatorships are restrictive arrangements that must be reserved for people with severe intellectual and/or developmental disabilities. However, California probate courts unnecessarily impose conservatorships and forego less restrictive alternatives for the sake of administrative convenience. While AB 1194 will ameliorate California’s paternalistic conservatorship system, this Note advocates for requiring courts to appoint counsel to all conservatees and proposed conservatees in every conservatorship proceeding, and to enact conservatorships only after proving less restrictive methods are insufficient. Humans—regardless of their dis/ability—deserve to age with dignity in a conservatee-centric system that does not violate their constitutional, federal, and state rights.

Collins '02 Leads High School Research Trip To Galápagos Islands With Carstens '02, Chris Francis

News and Events (Discontinued Series)

No abstract provided.

Policies For Digital Banking : Part - Ii, Ishrat Husain Dr.

Faculty Research - Newspaper and Magazine Articles

The journey in pursuit of the vision started in the early 2000s when the SBP decided to mandate banks to join one of either two ATM switches available in the country. The 1Link switch has played a critical role but still after two decades the number of ATMs remains 17,000 and only one million transactions are taking place every month mainly for cash withdrawal. The Electronic Transaction Ordinance was promulgated in 2000 providing legal recognition to digital signature and documentation reducing the risks associated with the use of electronic medium of business. Commercial banks were allowed to open and operate …

Feasibility Of [18f]Fspg Pet For Early Response Assessment To Combined Blockade Of Egfr And Glutamine Metabolism In Wild-Type Kras Colorectal Cancer, Seong-Woo Bae, Jianbo Wang, Dimitra K Georgiou, Xiaoxia Wen, Allison S Cohen, Ling Geng, Mohammed Noor Tantawy, H Charles Manning

Faculty, Staff and Student Publications

Early response assessment is critical for personalizing cancer therapy. Emerging therapeutic regimens with encouraging results in the wild-type (WT) KRAS colorectal cancer (CRC) setting include inhibitors of epidermal growth factor receptor (EGFR) and glutaminolysis. Towards predicting clinical outcome, this preclinical study evaluated non-invasive positron emission tomography (PET) with (4S)-4-(3-[18F]fluoropropyl)-L-glutamic acid ([18F]FSPG) in treatment-sensitive and treatment-resistant WT KRAS CRC patient-derived xenografts (PDXs). Tumor-bearing mice were imaged with [18F]FSPG PET before and one week following the initiation of treatment with either EGFR-targeted monoclonal antibody (mAb) therapy, glutaminase inhibitor therapy, or the combination. Imaging was correlated with tumor volume and histology. In PDX …

Spring Awakening (2023) | Program, Jacksonville State University

Department of Theatre & Film Performance Archive

Performed: 24-27 February 2023; "Spring Awakening" was based on the play by Frank Wedeking, book and lyrics by Steven Sater, and music and orchestrations by Duncan Sheik. The rock musical explores the journey from adolescence to adulthood. The director was Carolyn Conover, choreographer was Alison Woodward, music director was Michael Greenwood, fight and intimacy choreographer was Bridget McCarthy, scenic designer was Jason St. John, costume designer was Freddy Clements, lighting designer was Jenn Luck, make up designers were Freddy Clements and Addie Lot, sound designer was John A. Davis, conductor was Jacob Moorer, fight/dance/intimacy captains were Semaje Newton and Erin …

Multitrait Genome-Wide Analyses Identify New Susceptibility Loci And Candidate Drugs To Primary Sclerosing Cholangitis, Younghun Han, Jinyoung Byun, Catherine Zhu, Ryan Sun, Julia Y Roh, Heather J Cordell, Hyun-Sung Lee, Vikram R Shaw, Sung Wook Kang, Javad Razjouyan, Matthew A Cooley, Manal M Hassan, Katherine A Siminovitch, Trine Folseraas, David Ellinghaus, Annika Bergquist, Simon M Rushbrook, Andre Franke, Tom H Karlsen, Konstantinos N Lazaridis, Kathryn A. Mcglynn, Katherine A Mcglynn, Lewis R Roberts, Christopher I Amos, International Psc Study Group

Faculty, Staff and Students Publications

Primary sclerosing cholangitis (PSC) is a rare autoimmune bile duct disease that is strongly associated with immune-mediated disorders. In this study, we implemented multitrait joint analyses to genome-wide association summary statistics of PSC and numerous clinical and epidemiological traits to estimate the genetic contribution of each trait and genetic correlations between traits and to identify new lead PSC risk-associated loci. We identified seven new loci that have not been previously reported and one new independent lead variant in the previously reported locus. Functional annotation and fine-mapping nominated several potential susceptibility genes such as MANBA and IRF5. Network-based in silico drug …

Microrna Profiles In Intestinal Epithelial Cells In A Mouse Model Of Sepsis, Siqingaowa Caidengbate, Yuichi Akama, Anik Banerjee, Khwanchanok Mokmued, Eiji Kawamoto, Arong Gaowa, Louise D Mccullough, Motomu Shimaoka, Juneyoung Lee, Eun Jeong Park

Faculty, Staff and Student Publications

Sepsis is a systemic inflammatory disorder that leads to the dysfunction of multiple organs. In the intestine, the deregulation of the epithelial barrier contributes to the development of sepsis by triggering continuous exposure to harmful factors. However, sepsis-induced epigenetic changes in gene-regulation networks within intestinal epithelial cells (IECs) remain unexplored. In this study, we analyzed the expression profile of microRNAs (miRNAs) in IECs isolated from a mouse model of sepsis generated via cecal slurry injection. Among 239 miRNAs, 14 miRNAs were upregulated, and 9 miRNAs were downregulated in the IECs by sepsis. Upregulated miRNAs in IECs from septic mice, particularly …

Who Cares For The Young Carers?, R. Witton, A. Nelder

Peninsula Dental School

No abstract provided.

Editorial: The Health Informatics Series: Evolving With A New Discipline, Marion Ball, Kathryn J. Hannah, Nhora Cortes-Comerer, Judith V. Douglas

Elsevier Open Access Agreement Publications-Archive

A brief history of the book series launched by Springer-Verlag in 1988 as Computers in Healthcare stands as a case study of its role in the development of informatics in medicine. Renamed Health Informatics in 1998, the series grew to include 121 titles as of September 2022, covering topics from dental informatics to ethics, from human factors to mobile health. An analysis of three titles now in their fifth editions reveals the evolution of content in the core disciplines of nursing informatics and health information management. Shifts in topics in the second editions of two landmark titles chart the history …

Microfluidic Concurrent Assessment Of Red Blood Cell Adhesion And Microcapillary Occlusion: Potential Hemorheological Biomarkers In Sickle Cell Disease, Yuncheng Man, Douglas H. Wu, Ran An, Karamoja Monchamp, Utku Goreke, Zoe Sekyonda, William J. Wulftange, Chiara Federici, Allison Bode, Lalitha V. Nayak, Umut A. Gurkan

Faculty Scholarship

Deformability and non-adherence are two fundamental functional properties of red blood cells (RBCs), which allow them to move unimpeded through the microvasculature. In sickle cell disease (SCD), polymerization of abnormal sickle hemoglobin leads to decreased deformability and increased membrane adhesiveness in RBCs. This contributes to abnormal blood vessel occlusion, which is central to the underlying pathophysiology. RBC deformability and adhesiveness are, therefore key hemorheological biomarkers in characterizing disease states as well as in evaluating novel therapeutics. To date, these important interrelated biomarkers have been assessed in distinct laboratory assays, without integration or concurrent assessment in vitro. To this end, we …

“It's Important To Talk About These Issues”: The Need For Leaders To Establish Connections And Address Students' Experiences And Concerns, Elizabeth Gil

GSE Faculty Publications

In this Conversations in Urban Education, high school student leader Sofia Dí­az shares her experience with racial and gender inequity and justice while transitioning into high school in the 2020-2021 school year and attending school virtually and in-person during the continued pandemics of Covid-19 and racial injustice. Díaz provides insights on how educational leaders and staff can build relationships and reach out to students and families in order to support student well-being and safety. Díaz's experiences and observations highlight the myriad issues students and families face and the importance of supporting students through increasing awareness of resources and developing coping …

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.