Digital Commons Network^™

Four Futures For Occupational Safety And Health, Sarah A Felknor, Jessica M K Streit, Nicole T Edwards, John Howard

Faculty, Staff and Student Publications

Rapid changes to the nature of work have challenged the capacity of existing occupational safety and health (OSH) systems to ensure safe and productive workplaces. An effective response will require an expanded focus that includes new tools for anticipating and preparing for an uncertain future. Researchers at the U.S. National Institute for Occupational Safety and Health (NIOSH) have adopted the practice of strategic foresight to structure inquiry into how the future will impact OSH. Rooted in futures studies and strategic management, foresight creates well-researched and informed future scenarios that help organizations better prepare for potential challenges and take advantage of …

Greater Grison (Galictis Vittata) Predation Events Upon Paca (Cuniculus Paca) Suggest A Cavity Targeted Hunting Strategy By Greater Grison, Andrew Whitworth

Neotropical Biodiversity

No abstract provided.

Evidence-Based Practice Sustainability And Nursing Professional Governance, Melora D. Ferren

Dissertations

Patient care that is not based on evidence-based practice (EBP) could be considered malpractice, and it threatens patient safety, quality, and fiscal performance. EBP implementation is complex, and sustainment of these practices is such a persistent challenge that up to 70% of organizational change fails to be sustained. Sustainment of EBP decreases healthcare costs and improves patient outcomes. Professional attributes that influence sustainability are not well understood. Nursing professional governance (PG) is a framework of professional attributes that includes accountability, professional obligation, collateral relationships, and decision-making. This framework includes attributes that are necessary for professionals to effectively govern their profession …

Nurse Educators' Consensus Opinion On Using An Academic Electronic Health Record: A Delphi Study, Darlene S. Hanson

Dissertations

The purpose of this study was to determine the opinions of nurse educators in the state of North Dakota (ND) who were using the academic Electronic Health Record (EHR) known as SimChart. In this dissertation research study, factors that either hindered or facilitated the introduction of SimChart in nursing programs in ND were examined. Additionally, opinions were sought from nurse educators regarding whether or not SimChart contributed to student learning.

Li-Rads: Looking Back, Looking Forward, Victoria Chernyak, Kathryn J Fowler, Richard K G Do, Aya Kamaya, Yuko Kono, An Tang, Donald G. Mitchell, Jeffrey Weinreb, Cynthia S Santillan, Claude B Sirlin

Department of Radiology Faculty Papers

Since its initial release in 2011, the Liver Imaging Reporting and Data System (LI-RADS) has evolved and expanded in scope. It started as a single algorithm for hepatocellular carcinoma (HCC) diagnosis with CT or MRI with extracellular contrast agents and has grown into a multialgorithm network covering all major liver imaging modalities and contexts of use. Furthermore, it has developed its own lexicon, report templates, and supplementary materials. This article highlights the major achievements of LI-RADS in the past 11 years, including adoption in clinical care and research across the globe, and complete unification of HCC diagnostic systems in the …

Exploring Current And Future Research Trends On Safety Climate In Construction Projects, Kamugisha Joseph Kajumulo

Tanzania Journal of Engineering and Technology (TJET)

Clients, consultants, and contractors in the construction industry can benefit from a safety climate by obtaining knowledge of attitudes and perceptions for better safety outcomes. However, the current and future research trends for safety climate in construction projects have not yet been fully examined. In order to solve this problem, a systematic review of previous research findings using a social network approach must be conducted, and future trends for the safety climate in building projects must be identified. Sixty-three peer reviewed articles were gathered to study the literature on safety climate in construction projects. A social network approach was employed …

The Fourth Industrial Revolution: Opportunities And Challenges To The Future Of Mechanical Engineering, Ulingeta O.L. Mbamba

Tanzania Journal of Engineering and Technology (TJET)

This paper provides a conceptual overview of the developments of the Fourth Industrial Revolution (4IR) and derives challenges and opportunities for the future of the mechanical engineering profession. The paper broadly defines 4IR as the fusion of technologies and interaction across physical, digital and biological aspects, while defining mechanical engineering as "a multi-faceted discipline that encompasses the teaching, practice and guidance of others in the development and application of scientific principles to mechanical systems". The paper looks specifically at developments in the Internet of Things (IoT), blockchain technology, robotics, Big Data analytics, biotechnology, nanotechnology, 3D printing and artificial intelligence and …

Gait And Turning Characteristics From Daily Life Increase Ability To Predict Future Falls In People With Parkinson’S Disease, Vrutangkumar Shah, Adam Jagodinsky, James Mcnames, Multiple Additional Authors

Electrical and Computer Engineering Faculty Publications and Presentations

Objectives: To investigate if digital measures of gait (walking and turning) collected passively over a week of daily activities in people with Parkinson’s disease (PD) increases the discriminative ability to predict future falls compared to fall history alone. Methods: We recruited 34 individuals with PD (17 with history of falls and 17 non-fallers), age: 68 ± 6 years, MDS-UPDRS III ON: 31 ± 9. Participants were classified as fallers (at least one fall) or non-fallers based on self-reported falls in past 6 months. Eighty digital measures of gait were derived from 3 inertial sensors (Opal® V2 System) placed on the …

Impact Of Duodenal Pathology On Oral Drug Bioavailability And Disease Outcomes In Pediatric Crohn's Disease., Rebecca Casini, Carrie A. Vyhlidal, Julia M. Bracken, Ashley K. Sherman, Atif Ahmed, Vivekanand Singh, Veronica Williams, Valentina Shakhnovich

Manuscripts, Articles, Book Chapters and Other Papers

Background: Crohn's disease with upper gastrointestinal tract involvement occurs more often in children than adults and has the potential to interfere with oral drug absorption. We aimed to compare disease outcomes in children receiving oral azathioprine for the treatment of Crohn's disease with (DP) and without (NDP) duodenal pathology at diagnosis.

Methods: Duodenal villous length, body mass index (BMI), and laboratory studies were compared in DP vs. NDP during the first year post-diagnosis, using parametric/nonparametric tests and regression analysis (SAS v9.4); the data are reported as the median (interquartile range) or the mean ± standard deviation. Thiopurine metabolite concentration (pmol/8 …

Knowledge Graph Empowered Machine Learning Pipelines For Improved Efficiency, Reusability, And Explainability, Revathy Venkataramanan, Aalap Tripathy, Martin Foltin, Hong Yung Yip, Annmary Justine, Amit Sheth

Publications

Artificial intelligence (AI) pipelines are complex, heavily parameterized, and expensive to execute in terms of time and computational resources. Consequently, it is onerous to run experiments with all possible parameter combinations to achieve an optimal solution. However, these AI experiments can be optimized by recommending relevant parameters to commence the experiments, reducing search space significantly, which can be fine tuned further. The relevant parameters can be identified by observing the metadata of pipelines executed in the past, and the relevant pipeline with relevant parameters can be recommended to the user. Currently, there are various metadata frameworks that automatically record the …

The Relationship Between Explanatory Ability And Collegiate Learning Assessment Task, Monika Lintang Laksmi, Baskoro Adi Prayitno, Meti Indrowati

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

The literature study discusses the relationship between explanatory ability and Collegiate Learning Assessment (CLA) Task. The method used is a study of the literature related to explanatory ability and CLA Task, the literature studied from 2015 to 2022. The literature study results are CLA Task with an open-ended question, problem-based situations, and problem-solving can be used as an assessment of explanatory ability that consist of indicators for justifying procedures, state result, and present explanation. The achievement of the three indicators of explanatory ability that will be empowered with CLA Task needs the help of electronic module for media learning.

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

Jaml Immunotherapy Targets Recently Activated Tumor-Infiltrating Cd8+ T Cells, Simon Eschweiler, Alice Wang, Ciro Ramírez-Suástegui, Adrian Von Witzleben, Yingcong Li, Serena J Chee, Hayley Simon, Monalisa Mondal, Matthew Ellis, Gareth J Thomas, Vivek Chandra, Christian H Ottensmeier, Pandurangan Vijayanand

Faculty, Staff and Student Publications

Junctional adhesion molecule-like protein (JAML) serves as a co-stimulatory molecule in γδ T cells. While it has recently been described as a cancer immunotherapy target in mice, its potential to cause toxicity, specific mode of action with regard to its cellular targets, and whether it can be targeted in humans remain unknown. Here, we show that JAML is induced by T cell receptor engagement, reveal that this induction is linked to cis-regulatory interactions between the CD3D and JAML gene loci. When compared with other immunotherapy targets plagued by low target specificity and end-organ toxicity, we find JAML to be mostly …

Prognostic Significance Of Acellular Mucin In Patients Undergoing Cytoreductive Surgery And Hyperthermic Intraperitoneal Chemotherapy (Crs/Hipec) For Appendiceal Neoplasms, Derek J Erstad, Kristen A Robinson, Karen Beaty, Safia Rafeeq, Yi-Ju Chiang, Kanwal Raghav, John P Shen, Michael J Overman, Wai Chin Foo, Melissa W Taggart, Paul F Mansfield, Richard E Royal, Keith F Fournier, Christopher P Scally

Faculty, Staff and Student Publications

Introduction: Appendiceal neoplasms have a propensity for peritoneal dissemination. The standard of care for select individuals is CRS/HIPEC. In the current 8th AJCC Staging system, a finding of only intraperitoneal acellular mucin (M1a) is classified as Stage IVa. There is concern that the current AJCC system may over-stage patients.

Methods: This was a single-institution retrospective review of 164 cases of mucinous appendiceal neoplasm. Patients undergoing CRS/HIPEC with M1a disease were compared to patients with peritoneal deposits containing tumor cells (well-differentiated adenocarcinoma; low-grade mucinous carcinoma peritonei-M1b,G1). Overall and recurrence-free survival were assessed.

Results: Median age was 51 years, 70% were female, …

Cedar: Incorporating Cell Type Hierarchy Improves Cell Type-Specific Differential Analyses In Bulk Omics Data, Luxiao Chen, Ziyi Li, Hao Wu

Faculty, Staff and Student Publications

Bulk high-throughput omics data contain signals from a mixture of cell types. Recent developments of deconvolution methods facilitate cell type-specific inferences from bulk data. Our real data exploration suggests that differential expression or methylation status is often correlated among cell types. Based on this observation, we develop a novel statistical method named CeDAR to incorporate the cell type hierarchy in cell type-specific differential analyses of bulk data. Extensive simulation and real data analyses demonstrate that this approach significantly improves the accuracy and power in detecting cell type-specific differential signals compared with existing methods, especially in low-abundance cell types.

Recovering False Negatives In Crispr Fitness Screens With Jloe, Merve Dede, Traver Hart

Faculty, Staff and Student Publications

It is widely accepted that pooled library CRISPR knockout screens offer greater sensitivity and specificity than prior technologies in detecting genes whose disruption leads to fitness defects, a critical step in identifying candidate cancer targets. However, the assumption that CRISPR screens are saturating has been largely untested. Through integrated analysis of screen data in cancer cell lines generated by the Cancer Dependency Map, we show that a typical CRISPR screen has a ∼20% false negative rate, in addition to library-specific false negatives. Replicability falls sharply as gene expression decreases, while cancer subtype-specific genes within a tissue show distinct profiles compared …

Analisa Faktor-Faktor Penyebab Terjadinya Keterlambatan Tindakan Operasi (Delay To Operation) Di Instalasi Rawat Darurat Rsup Sanglah Desember 2017 – Februari 2018, Rusdi A, Amal Chalik Sjaaf

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

Surgery service is one of the health services in a hospital that can describe the quality of the hospital. Sanglah Hospital, Denpasar is a hospital at the provincial level which has a long waiting time for surgery. The long waiting time for surgery is generally related to factors such as the availability of facilities and infrastructure, human resources, and the length of time for approval from patients and families for surgery. Research is needed to determine the factors that significantly form the basis for determining policies at the Sanglah General Hospital level, especially in the Emergency Room, to improve operating …

Designing And Manufacturing Of Vegetable Slicing Machine, Juma Nuhu Msuya

Tanzania Journal of Engineering and Technology (TJET)

Agro-processing industry is faced with a challenge of slicing of vegetables for immediate consumption. This stems from the fact that the traditional slicing methods use bare hands, and knives. This method is faced with shortcomings of inefficiency, poor hygiene, and significant dangers to injury. If vegetables are not sliced, their drying takes longer, may possibly be spoiled, and cannot be stored for future uses. Therefore, this paper strives to design a vegetable slicing machine to increase the efficiency of the drying process as a post-processing step. The study employed a Pugh’s design model to design the machine and manufacture it. …

Is The Automatic Stabilizer Policy Effective In Combating An Economic Recession? A Case Study Of The Indonesian State Budget, Cucun Ahmad Syamsurijal, Yogi Suprayogi Sugandi, Asep Sumaryana, Slamet Usman Ismanto

Bulletin of Monetary Economics and Banking

This paper examines the effectiveness of an automatic fiscal policy in dealing with an economic recession in Indonesia. By using a mixture of quantity and quality approaches, we find that the automatic stabilizer policy can be used in Indonesian state finances, whereby several components of state revenue, namely income tax, consumption tax, excise, and non-tax revenue, have elasticity of more than one. In comparison, only one component of government spending, namely interest payment, has an elasticity of more than one. We also find that activating the automatic stabilizer policy requires a particular article in the State Finance Law, that regulates …

Credit Card Delinquency In Malaysia, Wai Leng Chia, Roy W.L Khong, Priscilla Lim, Patricia Mei Mei Ang

Bulletin of Monetary Economics and Banking

The objective of this paper is to investigate the influence of economic conditions and regulatory interventions as potential drivers of credit card delinquency in Malaysia. Using quarterly data from 1999 to 2021 and the autoregressive distributed lag model, we find that national income, wealth, expectations of future economic conditions, and the supply of credit determine credit card delinquency. We also find evidence in favour of regulatory interventions as a solution to curbing the deteriorating credit card debt situation in Malaysia.

Determinants Of Bank Performance: Revisiting The Role Of Ceo’S Personality Traits Using Graphology, Thanh Ngo, Tu Dq Le, Dat T. Nguyen, Tin H. Ho

Bulletin of Monetary Economics and Banking

It is well-known that chief executive officer (CEO) plays an important role in the success of many businesses. In this study, we revisit the relationship between CEO’s personality and firm performance for 27 Vietnamese commercial banks. We use graphology to classify 299 handwritten signatures of CEOs into different personality traits such as extraversion or conscientiousness. Those personalities, among other factors (e.g., ownership, listed status, and CEOs’ experiences), are then used to explain bank performance. We document that banks with conscientious CEOs tend to outperform their counterparts.

Network Analysis Of Large-Scale Immgen And Tabula Muris Datasets Highlights Metabolic Diversity Of Tissue Mononuclear Phagocytes, Anastasiia Gainullina, Denis A Mogilenko, Li-Hao Huang, Ki-Wook Kim, Karen Krchma, Jun Wu, Geetika Bajpai, Peter Wang, Kyunghee Choi, Kory Lavine, Gwendalyn J Randolph, Alexey Sergushichev, Maxim N Artyomov, Et Al.

2020-Current year OA Pubs

The diversity of mononuclear phagocyte (MNP) subpopulations across tissues is one of the key physiological characteristics of the immune system. Here, we focus on understanding the metabolic variability of MNPs through metabolic network analysis applied to three large-scale transcriptional datasets: we introduce (1) an ImmGen MNP open-source dataset of 337 samples across 26 tissues; (2) a myeloid subset of ImmGen Phase I dataset (202 MNP samples); and (3) a myeloid mouse single-cell RNA sequencing (scRNA-seq) dataset (51,364 cells) assembled based on Tabula Muris Senis. To analyze such large-scale datasets, we develop a network-based computational approach, genes and metabolites (GAM) clustering, …

Types Of Physical Activity In Nonalcoholic Fatty Liver Disease And All-Cause And Cardiovascular Mortality, Donghee Kim, Karn Wijarnpreecha, Brittany B Dennis, George Cholankeril, Aijaz Ahmed

Faculty, Staff and Students Publications

The impact of different types of physical activity (PA) on mortality in the context of nonalcoholic fatty liver disease (NAFLD) is not clearly defined and was investigated. This prospective study was performed using the 2007–2014 US National Health and Nutrition Examination Survey with mortality follow-up through 2019. Over a median follow-up of 8.6 years, leisure-time and transportation-related PA that fulfilled the criteria outlined in the PA guidelines (≥150 min/week) in NAFLD were associated with a risk reduction in all-cause mortality (hazard ratio [HR]: 0.76, 95% confidence interval [CI]: 0.59–0.98 for leisure-time PA; HR: 0.62, 95% CI: 0.45–0.86 for transportation-related PA). …

Clic And Membrane Wound Repair Pathways Enable Pandemic Norovirus Entry And Infection, B Vijayalakshmi Ayyar, Khalil Ettayebi, Wilhelm Salmen, Umesh C Karandikar, Frederick H Neill, Victoria R Tenge, Sue E Crawford, Erhard Bieberich, B V Venkataram Prasad, Robert L Atmar, Mary K Estes

Faculty, Staff and Students Publications

Globally, most cases of gastroenteritis are caused by pandemic GII.4 human norovirus (HuNoV) strains with no approved therapies or vaccines available. The cellular pathways that these strains exploit for cell entry and internalization are unknown. Here, using nontransformed human jejunal enteroids (HIEs) that recapitulate the physiology of the gastrointestinal tract, we show that infectious GII.4 virions and virus-like particles are endocytosed using a unique combination of endosomal acidification-dependent clathrin-independent carriers (CLIC), acid sphingomyelinase (ASM)-mediated lysosomal exocytosis, and membrane wound repair pathways. We found that besides the known interaction of the viral capsid Protruding (P) domain with host glycans, the Shell …

The Er Protein Translocation Channel Subunit Sbh1 Controls Virulence Of Cryptococcus Neoformans, Felipe H. Santiago-Tirado, Thomas Hurtaux, Jennifer Geddes-Mcalister, Duy Nguyen, Volkhard Helms, Tamara L Doering, Karin Römisch

2020-Current year OA Pubs

The fungal pathogen Cryptococcus neoformans is distinguished by a cell-wall-anchored polysaccharide capsule that is critical for virulence. Biogenesis of both cell wall and capsule relies on the secretory pathway. Protein secretion begins with polypeptide translocation across the endoplasmic reticulum (ER) membrane through a highly conserved channel formed by three proteins: Sec61, Sbh1, and Sss1. Sbh1, the most divergent, contains multiple phosphorylation sites, which may allow it to regulate entry into the secretory pathway in a species- and protein-specific manner. Absence of

Narrative Review Of Single Ventricle: Where Are We After 40 Years?, Antonio F Corno, Tina O Findley, Jorge D Salazar

Faculty, Staff and Student Publications

BACKGROUND AND OBJECTIVE: Key medical and surgical advances have been made in the longitudinal management of patients with "functionally" single ventricle physiology, with the principles of Fontan circulation applied to other complex congenital heart defects. The purpose of this article is to review all of the innovations, starting from fetal life, that led to a change of strategy for single ventricle.

METHODS: Our literature review included all full articles published in English language on the Cochrane, MedLine, and Embase with references to "single ventricle" and "univentricular hearts", including the initial history of the treatments for this congenital heart defects as …

Narrative Review Of Single Ventricle: Where Are We After 40 Years?, Antonio F Corno, Tina O Findley, Jorge D Salazar

Faculty, Staff and Student Publications

Background and objective: Key medical and surgical advances have been made in the longitudinal management of patients with "functionally" single ventricle physiology, with the principles of Fontan circulation applied to other complex congenital heart defects. The purpose of this article is to review all of the innovations, starting from fetal life, that led to a change of strategy for single ventricle.

Methods: Our literature review included all full articles published in English language on the Cochrane, MedLine, and Embase with references to "single ventricle" and "univentricular hearts", including the initial history of the treatments for this congenital heart defects as …

Low-Altitude Uav Imaging Accurately Quantifies Eelgrass Wasting Disease From Alaska To California, Bo Yang, Timothy L. Hawthorne, Lillian Aoki, Deanna S. Beatty, Tyler Copeland, Lia K. Domke, Ginny L. Eckert, Carla P. Gomes, Olivia J. Graham, C. Drew Harvell, Kevin A. Hovel, Margot Hessing-Lewis, Leah Harper, Ryan S. Mueller, Brendan Rappazzo, Luba Reshitnyk, John J. Stachowicz, Fiona Tomas, J. Emmett Duffy

Faculty Research, Scholarly, and Creative Activity

Declines in eelgrass, an important and widespread coastal habitat, are associated with wasting disease in recent outbreaks on the Pacific coast of North America. This study presents a novel method for mapping and predicting wasting disease using Unoccupied Aerial Vehicle (UAV) with low-altitude autonomous imaging of visible bands. We conducted UAV mapping and sampling in intertidal eelgrass beds across multiple sites in Alaska, British Columbia, and California. We designed and implemented a UAV low-altitude mapping protocol to detect disease prevalence and validated against in situ results. Our analysis revealed that green leaf area index derived from UAV imagery was a …

Engineering A Modular 44ti/44sc Generator: Eluate Evaluation In Preclinical Models And Estimation Of Human Radiation Dosimetry, Nadia Benabdallah, Hanwen Zhang, Ryan Unnerstall, Amanda Fears, Lucy Summer, Michael Fassbender, Buck E Rodgers, Diane Abou, Valery Radchenko, Daniel L J Thorek

2020-Current year OA Pubs

BACKGROUND:

METHODS:

RESULTS:

CONCLUSIONS: A clinical-scale

Unpacking The Proteome And Metaproteome Of The Black Soldier Fly Larvae: Efficacy And Complementarity Of Multiple Protein Extraction Protocols, Utpal Bose, Angela Juhasz, Sally Stockwell, Sophia Escobar-Correas, Anna Marcora, Cate Paull, James A. Broadbent, Gene Wijffels

Research outputs 2022 to 2026

The larvae of the black soldier fly (BSF), Hermetia illucens (Diptera: Stratiomyidae), have demonstrated the ability to efficiently bioconvert organic waste into a sustainable source of food and feed, but fundamental biology remains to be discovered to exploit their full biodegradative potential. Herein, LC-MS/MS was used to assess the efficiency of eight differing extraction protocols to build foundational knowledge regarding the proteome landscape of both the BSF larvae body and gut. Each protocol yielded complementary information to improve BSF proteome coverage. Protocol 8 (liquid nitrogen, defatting, and urea/thiourea/chaps) was better than all other protocols for the protein extraction from larvae …