Digital Commons Network^™

Development Of Fibroblast/Endothelial Cell-Seeded Collagen Scaffolds For In Vitro Prevascularization, Daniela S. Masson-Meyers, Fahimeh Tabatabaei, Lane Steinhaus, Jeffrey M. Toth, Lobat Tayebi

Biomedical Engineering Faculty Research and Publications

The development of vascularized scaffolds remains one of the major challenges in tissue engineering, and co-culturing with endothelial cells is known as one of the possible approaches for this purpose. In this approach, optimization of cell culture conditions, scaffolds, and fabrication techniques is needed to develop tissue equivalents that will enable in vitro formation of a capillary network. Prevascularized equivalents will be more physiologically comparable to the native tissues and potentially prevent insufficient vascularization after implantation. This study aimed to culture human umbilical vein endothelial cells (HUVECs), alone or in co-culture with fibroblasts, on collagen scaffolds prepared by simple fabrication …

Multicultural Counselor Supervision And Perceived Differences On Client Outcome, Andrew Perez, Saara Grizzell, Jerome Fischer, Jennifer Jazinski

School of Rehabilitation Services & Counseling Faculty Publications

The purpose of this study was to examine the differences between counselor supervisors’ and supervisees’ perceptions of the impact of multicultural supervision on client outcome. Counselor supervisors and supervisees may have differences in how much they believe multicultural factors affect client outcome and this study aimed to determine what differences exist. There were 61 participants in the study consisting of faculty, counselor supervisors, counselors, and graduate students in counseling-related fields. The current study found that multicultural supervision/competence alone predicted supervisor perceptions of client outcome. The findings suggest that training in supervision and multicultural supervision is vital to the professional development …

Psychoanalytic Insights For Rehabilitation Professionals: Three Major Psychoanalytic Perspectives., Kenneth R. Thomas, David M. Rosenthal, Zhou Kaiqi, Jeong Han Kim

School of Rehabilitation Services & Counseling Faculty Publications

This manuscript presents data on how counselors can use theoretical concepts derived from three major schools of psychoanalysis to understand and treat clients with a disability. We survey historical data on the three schools of psychoanalysis (classical, ego psychology, and self-psychology), as well as detailed information on the founders and major contributors to these various schools of psychoanalysis. The data are presented not only to inform counselors about the three approaches to psychoanalysis, but also to help practitioners facilitate their clients' emotional health. In other words, the manuscript serves both an educational and clinical objective.

Anaphylaxis, Children's Mercy Kansas City

Clinical Pathways (Formally Known As Clinical Practice Guidelines)

No abstract provided.

A Cross Sectional Study Investigating Dynamic Balance When Stepping To Targets In Children With Cerebral Palsy Compared To Typically Developing Children, Rachel Rapson, Jos M. Latour, Bernie Carter, Vasiliki Pitsouni, Jonathan F. Marsden

School of Nursing and Midwifery

BackgroundChildren with Cerebral Palsy (CP) have altered anticipatory postural adjustments (APAs) during gait initiation. These APAs may affect dynamic balance in tasks such as stepping.Research questionsHow are APAs in children with CP affected during stepping to precise targets? How do children with CP modulate APAs when stepping to medial and lateral targets? What is the association between APAs and symptom severity, movement quality and impairment profile?MethodChildren undertook a stepping task to laterally and medially placed targets with either leg, in a randomised order. Movement of the centre of pressure (COP) and markers at the pelvis and foot were measured via …

Practice Management: Cpa Vs. Dental Cpa: What’S The Difference?, John Looby Cpa

The Journal of the Michigan Dental Association

This article underscores the advantages of working with a specialized dental Certified Public Accountant (CPA) over generalist CPAs or accountants for dental practitioners. A dental CPA offers deeper insights into practice management, tax planning, and financial strategies tailored to the dental industry. Dental CPAs provide valuable guidance on production, insurance, and cost management, helping dentists make informed decisions. They also prove invaluable during critical times, such as during the COVID-19 pandemic, and offer expertise in tax, retirement, and practice transition planning, ensuring optimal financial outcomes for dentists.

Timolol As A Migraine Acute Attack Therapy: Randomized, Otcs Control Study, Shimaa Elgamal, Hossam Egila, Ibrahim Kabbash, Hussien El-Ansarey, Mohamed Elshafie, Osama Elshafei

Mansoura Medical Journal

Background: Migraine is manifested by recurrent headache attacks, with variable characteristics and associated symptoms. Oral beta blockers are widely used to prevent and reduce the frequency these attacks. However, the use of topical beta blockers for acute treatment is still controversial. Aims: In this randomized double – armed study, we aim to compare the efficacy of Timolol 0.5% eyedrops compared to other over-the-counter (OTC) medications used for acute treatment of migraine. Methods: Fifty-seven patients were randomly allocated to group A (treatment group: Timolol 0.5% eyedrops), and group B (control group: OTC drugs including Non-steroidal anti-inflammatory drugs (NSAIDs), caffeine, aspirin, and …

Assessment Of Serum Levels Of Cxcl10 In Patients With Non-Segmental Vitiligo, Sara Khashaba, Mohammed Hussein Elmogy, Hanan Fathy Mohamed, Mohammad El-Nablaway, Ahmed Fawzi Ismael

Mansoura Medical Journal

Background: Vitiligo is the most common depigmenting skin disorder. Destruction of melanocytes result in depigmented skin lesions. Pathogenesis is not fully understood and mostly is multifactorial. However, the autoimmune theory is the most widely accepted one. The interaction between genetic, environmental, biochemical and immunologic factors contribute to the disease. Cytokines have an important role in development of the disease and its progression. Aim of the work: The aim of the present study is to measure the blood levels of C-X-C motif chemokine ligand 10 (CXCL10) in vitiligo and to correlate it with disease activity and severity. Methods: This is a …

Intrinsic Programmed Death Ligand 1 (Pd-L1) Role In Promoting Triple Negative Breast Cancer (Tnbc) Progression, Duaa Salem Alkaabi

Theses

This thesis is concerned with Triple Negative Breast Cancer (TNBC), which is characterized by lack of estrogen, progesterone, and HER2 receptors expression, making targeted drugs ineffective. TNBC has a high proliferative rate, which results in a poor prognosis. Chemotherapy, the primary treatment for metastatic breast cancer, is not an ideal choice due to its toxicity towards normal cells. Therefore, Cancer-targeted therapy has been developed to improve the specificity and strength of the immune system against cancer cells. PD-L1 is an immunosuppressive protein that inactivates T cells by binding to the inhibitory receptor PD-1. The clinical use of PD-L1 blockade agents …

Emerging Trends And Challenges Of Corporate Social Responsibility: The Case Of The United Arab Emirates, Noura Eisa Al Harasi

Theses

This research shed light on the concept of Corporate Social Responsibility (CSR) in the United Arab Emirates (UAE) by examining the trends, benefits, and challenges of CSR in the UAE. The research contributed to the literature in the field of CSR by providing a comprehensive understanding of the concept in a non-Western context that can represent a generalizable model, not only for the UAE, but also for Gulf Cooperation Council (GCC) countries that share similar corporate culture with the UAE. In this regard, the research serves as a reference work into CSR beyond the UAE as it answered the following …

Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Draft Final 2023 Residential Metals Abatement Program Borrow Amendment Work Plan (Dated January 12, 2023), Nikia Greene

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Engaging In Self-Directed Leisure Activities During A Homework-Free Holiday: Impacts On Primary School Children In Hong Kong, Vicky C. Tam, Phoebe Chu, Viola Tsang

Journal of Global Education and Research

Homework is a core pedagogical tool used by schools around the world. Yet concern for heavy homework load has been raised regarding stress on students and families and how it may overshadow opportunities for non-academic development. Drawing support from Self-Determination Theory and Hope Theory, an innovative intervention project was designed to create homework-free opportunities for school children to take part in freely chosen self-directed leisure activities. The project was implemented in four primary schools in Hong Kong during the Easter holiday in 2017 and 2018. A mixed-method evaluation was conducted to appraise the experiences of student participants as well as …

The Pandemic Anxiety Inventory: A Validation Study, Irvin Sam Schonfeld, Tasmyn Prytherch, Mark Cropley, Renzo Bianchi

Publications and Research

The Pandemic Anxiety Inventory (PAI) assesses anxiety symptoms individuals attribute to the presence of a pandemic. We conducted this study of 379 British adults during the COVID-19 pandemic and found that the PAI exhibited excellent reliability and solid criterion validity. Pandemic anxiety was associated with reduced social support, anticipated life changes, financial strain, job loss, economic insecurity, and the hospitalization or death of a close friend or relative. Using correlational and bifactor analyses, we found that the PAI demonstrated solid convergent and discriminant validity. The findings suggest that the PAI can be used in research and clinical practice.

Law Library Blog (March 2023): Legal Beagle's Blog Archive, Roger Williams University School Of Law

Law Library Newsletters/Blog

No abstract provided.

Let's Talk Body: An Applied Senior Project On Social Media Body Image, Katherine R. Tonges, Lindsey J. Dwyer

Communication Studies

This paper discusses the overwhelming presence of social media platforms like Instagram and TikTok in the recent generation's (Gen-Z) daily lives. Influencers have become the new celebrities by creating a “relatable and desirable” lifestyle that users aspire to gain. However, the pressure to conform to unrealistic beauty standards and buy promoted products can lead to negative effects on users' mental health and self-esteem. The authors of this paper (Tonges and Dwyer) have created a podcast and Instagram account to encourage an honest conversation about the impact of social media on one’s actions, emotions, and brain chemistry. By analyzing social media …

Logic Model And Data System Recommendations, Kristen Lacijan, Claire Devine, Natalie Royal Kenton, Maggie Weller

View All

No abstract provided.

Assessing The Toxicity Of Aluminum Oxide Nanoparticles (Al2o3 Nps) Prepared By Laser Ablation Technique On Blood Components, Tuqa Sabah, Kareem H. Jawad, Nebras Essam

Journal of Applied Sciences and Nanotechnology

Along with its uses in a wide range of sectors, NP toxicity research was one of the fastest-growing areas of research, so the growing commercial applications brought aluminum oxide nanoparticles under the purview of toxicologists. This study shows the toxicity of Aluminum oxide Nanoparticles on blood components prepared using the pulsed laser ablation (PLA) Nd: YAG laser method. We confirmed the synthesis of aluminum Oxide nanoparticles by measuring color absorbance, UV-vis, scanning electron microscope techniques (SEM), and FTIR as characterization of Aluminum oxide Nanoparticles. The complete blood count (CBC) was used in the study of the toxicity effect of these …

Antioxidant Properties Of Galangin With Β-Cyclodextrin: An In Vitro And In Vivo, Zainab Abbas, Ghassan Sulaiman, Majid Jabir, Hamdoon Mohammed, Salman Mohammed

Journal of Applied Sciences and Nanotechnology

Galangin, a non-toxic phytochemical, is known to have a variety of therapeutic uses. This study looked into the role of inclusion complexes of galangin/β-cyclodextrin in increasing antioxidant activity over pure galangin. The role of this inclusion complex in increasing antioxidant activity in comparison to pure galangin. In this study, hydrogen peroxide assays were used in vitro. Galangin demonstrated concentration-dependent scavenging action in the 2-50 µg mL-1 range, with the highest level of activity possible 92.00% at 50 µg mL-1. In pure galangin, a decrease of 85.00% was observed. The ferric thiocyanate lipoperoxidation method was clarified by using galangin and galangin/β-cyclodextrin …

Biosynthesis And Optimization Of Polyhydroxyalkanoate (Pha) Production By Acinetobacter Lwoffii Isolate, Karrar Hameed, Iman Gatea, Amal Hussein

Journal of Applied Sciences and Nanotechnology

Polyhydroxyalkanoate (PHA) is an eco-friendly polymer that has various important biomedical uses, as well as biodegradability, drug delivery, and medical implants. It is a kind of polyester synthesized by various microorganisms as energy reserve material under inappropriate conditions. This study focused on testing waste cooking oil as the source of carbon to optimize PHA production. The tests included the most important environmental components within the culture medium affecting the growth of the bacterial isolate under the experiment and its ability to produce a polymer. Results revealed that the cultivation of Acinetobacter lwoffii, pre-isolated from hydrocarbon contaminated soil, under optimum conditions …

Oncolytic Ndv-Amha1 Strain Effective Against Glioblastoma Cancer Cells, Zahraa Kadhim, Ghassan Sulaiman, Ahmed Al-Shammari, Hamdoon Mohammed, Salman Mohammed

Journal of Applied Sciences and Nanotechnology

Glioblastoma multiforme (GBM) is one of the most life-threatening types of cancer that is difficult to treat. The search for effective yet safe therapy is progressing and non-conventional therapies such as using viruses as a smart and selective agent against cancer are promising. The aim of the study was the presence of a reliable method to use Newcastle disease virus (NDV) as an oncolytic agent against GBM, which attempted to propagate the NDV in laboratory experiments. Ahmed Majeed Hamza Al-Shammari-1 (AMHA1) attenuated strain of NDV was propagated in chicken embryos. The virus's tittered in Vero-slamed cells to determine the infective …

Study Of The Physicochemical And Microbiological Properties Of Mozzarella Cheese Coated With Edible Casings Subsidized With Green Tea, Ihab Abdulhadi, Mahdi Shakak, Kifah Doosh

Journal of Applied Sciences and Nanotechnology

In this study, mozzarella cheese covered with edible biodegradable films made from whey proteins reinforced with green alcoholic extract was manufactured to reduce environmental impact from degradable plastics. Two types of mozzarella cheese were produced: the first unwrapped (control) and the second coated with whey proteins fortified with 3% green tea (envelope sample). The effect on prolonging storage life was evaluated by chemical and microbiological tests. The moisture content on the first day was 53.26% and 53.30% for the control and envelope samples, respectively. This percentage decreased significantly (P≤0.05) on the last day to 47% and 51.06%, respectively. The pH …

Extraction And Purification Of Pullulanase From Local Mushrooms, Dalal Bedan

Journal of Applied Sciences and Nanotechnology

Pullulanase is defined as an extracellular carbohydrase enzyme responsible for the hydrolysis of pullulan into maltotriose. Pullulanase can be extracted from Agaricus bisporus edible mushroom and concentrated by dialysis tube using Tris-HCl buffer. This enzyme was purified by different ratios of ammonium sulphate; the optimal ratio was 30%. It can be purified by ion exchange using a DEAE-cellulose column with a final yield of 5.25 and a purification fold of 4.38. Following Sephadex G-100 gel filtration with a yield of 2.60 and purification fold of 5.0, the total activity of the enzyme reached 160IU and the specific activity was 14.5 …

Role Of Microalgae In Environmental Biotechnology To Remove Heavy Metals, Muzhda Qader, Yahya Shekha

Journal of Applied Sciences and Nanotechnology

The objective of the study is to evaluate the role of microalgae in heavy metal remediation (Pb and Cd). Three microalgae species were used (Tetradesmus nygaardi, Scenedesmus quadricauda, and Coelastrella sp.) with four concentrations of both tested heavy metals (lead and cadmium) were, (5, 15, 35, and 50 ppm). Samples were analyzed every 4th day during the experimental study for 20 days. The result showed that during experimental days the lower concentration (5ppm) has the highest reduction percent for Pb and Cd by all microalgal species (Tetradesmus nygaardi, Scenedesemus quadricauda, and Coellastrella sp.). Whereas Coellastrella sp. had the highest efficiency …

Pattern And Trends Of Helicobacter Pylori Genotypes In Gastric Cancer: A Kenyan 8-Year Study, Priscilla Njenga, Allan Njau, Zahir Moloo, Gunturu Revathi, Evariste Tshibangu, Yoshio Yamaoka

Pathology, East Africa

Background: Notable geographic and temporal variations in the prevalence and genotypes of Helicobacter pylori, in relation to gastric pathologies, have been observed; however, their significance and trends in African populations is scarcely described. The aim of this study, was to investigate the association of H. pylori and its respective CagA and vacuolating cytotoxin A (VacA) genotypes with gastric adenocarcinoma, and to describe the trends of H. pylori genotypes over an 8-year period (2012–2019).

Materials and methods: A total of 286 samples of gastric cancer cases and benign controls (one-to-one matching), from three main cities in Kenya, between …

Actin Cytoskeleton Vulnerability To Disulfide Stress Mediates Disulfidptosi, Xiaoguang Liu, Litong Nie, Yilei Zhang, Yuelong Yan, Chao Wang, Medina Colic, Kellen Olszewski, Amber Horbath, Xiong Chen, Guang Lei, Chao Mao, Shiqi Wu, Li Zhuang, Masha V Poyurovsky, M James You, Traver Hart, Daniel D Billadeau, Junjie Chen, Boyi Gan

Faculty, Staff and Student Publications

SLC7A11-mediated cystine uptake suppresses ferroptosis yet promotes cell death under glucose starvation; the nature of the latter cell death remains unknown. Here, we show that aberrant accumulation of intracellular disulfides in SLC7A11high cells under glucose starvation induces a previously uncharacterized form of cell death distinct from apoptosis or ferroptosis. We term this cell death disulfidptosis. Chemical proteomics and cell biological analyses showed that glucose starvation in SLC7A11high cells induces aberrant disulfide bonds in actin cytoskeleton proteins and F-actin collapse in a SLC7A11-dependent manner. CRISPR screens and functional studies revealed that inactivation of the WAVE regulatory complex (WRC, which promotes actin …

Highly Synchronized Cortical Circuit Dynamics Mediate Spontaneous Pain In Mice, Weihua Ding, Lukas Fischer, Qian Chen, Ziyi Li, Liuyue Yang, Zerong You, Kun Hu, Xinbo Wu, Xue Zhou, Wei Chao, Peter Hu, Tewodros Mulugeta Dagnew, Daniel M Dubreuil, Shiyu Wang, Suyun Xia, Caroline Bao, Shengmei Zhu, Lucy Chen, Changning Wang, Brian Wainger, Peng Jin, Jianren Mao, Guoping Feng, Mark T Harnett, Shiqian Shen

Faculty, Staff and Student Publications

Cortical neural dynamics mediate information processing for the cerebral cortex, which is implicated in fundamental biological processes such as vision and olfaction, in addition to neurological and psychiatric diseases. Spontaneous pain is a key feature of human neuropathic pain. Whether spontaneous pain pushes the cortical network into an aberrant state and, if so, whether it can be brought back to a "normal" operating range to ameliorate pain are unknown. Using a clinically relevant mouse model of neuropathic pain with spontaneous pain-like behavior, we report that orofacial spontaneous pain activated a specific area within the primary somatosensory cortex (S1), displaying synchronized …

Integrative Bioinformatic Analysis Of P53 And Pathway Alterations In Two Different Lung Cancer Subtypes, Yun Zhang, Abie Williams-Villalobo, Jyotsna D Godavarthi, Faith Shakoor, Shunbin Xiong, Bin Liu

Faculty, Staff and Student Publications

Whether p53, either wild type (WT) or mutant, plays cell-specific or uniform role remains controversial. Using The Cancer Genome Atlas, we examined p53 in the lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC), two lung cancers with different cellular origins and frequent p53 mutation (52% and 83%, respectively). Mutant p53 more strongly correlates with different genomic alteration and protein expression profiles in LUAD than in LUSC. p53 mutation in LUAD and LUSC is associated with multiple exacerbated clinical outcomes. Although the presence of p53 mutation does not change the survival of LUAD patients, LUSC patients containing p53 mutation exhibit …

Common Kinase Mutations Do Not Impact Optimal Molecular Responses In Core Binding Factor Acute Myeloid Leukemia Treated With Fludarabine, Cytarabine, And G-Csf Based Regimens, Jayastu Senapati, Tareq Abuasab, Fadi G Haddad, Farhad Ravandi, Tapan Kadia, Courtney Dinardo, Naval Daver, Naveen Pemmaraju, Yesid Alvarado, Mark A Brandt, Hagop Kantarjian, Gautam Borthakur

Faculty, Staff and Student Publications

No abstract provided.

Understanding Itch In Cutaneous T-Cell Lymphoma: Exploring The Impact Of Comorbidities, Treatment Regimens, And Racial Differences On Quality Of Life, Tejas P Joshi, Madeleine Duvic

Faculty, Staff and Student Publications

No abstract provided.

Human Papillomavirus Status And Prognosis Of Oropharyngeal High-Grade Neuroendocrine Carcinoma, Luana G De Sousa, Felippe Lazar Neto, Eduardo A Dal Lago, Andrew Sikora, Ehab Hanna, Amy Moreno, Jack Phan, Bonnie S Glisson, Diana Bell, Renata Ferrarotto

Faculty, Staff and Student Publications

Background: The prognostic impact of human papillomavirus (HPV) infection or smoking on oropharyngeal high-grade neuroendocrine carcinoma (HG-NEC) is not established.

Methods: Retrospective study with patients with oropharyngeal HG-NEC seen at MD Anderson Cancer Center from 1997 to 2020, and previously reported patients with oropharyngeal HG-NEC and known p16 and HPV status from the literature review. Survival was estimated with the Kaplan-Meier method, and survival differences assessed with the log-rank test and Cox proportional hazards models.

Results: Thirty patients were included; most had a heavy (≥10 pack-years) smoking history (52%), locoregional disease (stage III-IVB; 77%), and p16-positive tumor (92%). HPV was …