Digital Commons Network^™

Perivascular Cells Induce Microglial Phagocytic States And Synaptic Engulfment Via Spp1 In Mouse Models Of Alzheimer's Disease., Sebastiaan De Schepper, Judy Z Ge, Gerard Crowley, Laís S S Ferreira, Dylan Garceau, Christina E Toomey, Dimitra Sokolova, Javier Rueda-Carrasco, Sun-Hye Shin, Jung-Seok Kim, Thomas Childs, Tammaryn Lashley, Jemima J Burden, Michael Sasner, Carlo Sala Frigerio, Steffen Jung, Soyon Hong

Faculty Research 2023

Alzheimer's disease (AD) is characterized by synaptic loss, which can result from dysfunctional microglial phagocytosis and complement activation. However, what signals drive aberrant microglia-mediated engulfment of synapses in AD is unclear. Here we report that secreted phosphoprotein 1 (SPP1/osteopontin) is upregulated predominantly by perivascular macrophages and, to a lesser extent, by perivascular fibroblasts. Perivascular SPP1 is required for microglia to engulf synapses and upregulate phagocytic markers including C1qa, Grn and Ctsb in presence of amyloid-β oligomers. Absence of Spp1 expression in AD mouse models results in prevention of synaptic loss. Furthermore, single-cell RNA sequencing and putative cell-cell interaction analyses reveal …

The Stewardship Model Of Necessity, Joseph Graziano

Notre Dame Law Review

The current understanding of the necessity defense to trespass to property in American law stems from a simple—or perhaps simplistic—balancing of rights. Based in the individualistic understanding of property as a right against the world that creates an obligation for others, necessity pits the interloper’s right to life, liberty, or property against the property owner’s right. Although feasible in the extremes, dueling rights leads to an unwieldy judicial task, discouraging advocates from alleging the privilege and discouraging judges from recognizing the privilege. Overall, the right to exclude has become more and more the libertarian vision of a right to be …

A Prophylactic Approach To Compact Constitutionality, Katherine Mims Crocker

Notre Dame Law Review

From COVID-19 to climate change, immigration to health insurance, firearms control to electoral reform: state politicians have sought to address all these hot-button issues by joining forces with other states. The U.S. Constitution, however, forbids states to “enter into any Agreement or Compact” with each other “without the Consent of Congress,” a requirement that proponents of much interstate action, especially around controversial topics, would hope to circumvent.

The Supreme Court lets them do just that. By interpreting “any Agreement or Compact” so narrowly that it is difficult to see what besides otherwise unlawful coordination qualifies, the Court has essentially read …

Rotunda - Vol 103, No 5 - Feb 29, 2024, Longwood University

Rotunda

No abstract provided.

Mindfulness Strength Coaching To Combat Acute Anxiety In Veterans 25-45 Years Of Age, Lora Barocio

Cohort XI

EPVAHCS health care teams consist of various medical professionals that are highly experienced and place focus on the needs of veterans and those caring for them. There are currently 7 locations in the El Paso/Las Cruces area and there are still plans to expand in years to come. They provide quality evidence-based health care to thousands of qualified veterans. VA health care has evolved tremendously over the past few years. VA has greatly improved by translation of the knowledge into a patient centered practice and resulting in improved veteran outcomes. Since working at one of these locations for over 8 …

Implementation Of A Daily Spontaneous Breathing Trial Protocol, Berenice Monarez

Cohort XI

Patients in the intensive care unit who require endotracheal intubation are at higher risk of further complications and increased mortality. Inconsistent spontaneous awakening trials (SAT) and spontaneous breathing trials (SBT), mechanical ventilation weaning strategies, and interdisciplinary rounding processes contribute to prolonged mechanical ventilation duration and length of stay in intensive care. The (Robertson et al., 2008) study found utilization of an evidence-based protocol for endotracheally intubated patients will decrease days that a patient requires mechanical ventilation. Daily spontaneous-breathing trials (SBTs) are proclaimed as the best method for assessing readiness for discontinuation of mechanical ventilation. SBT protocols have also been shown …

The Scope Of Compelling Government Interests, R. George Wright

Notre Dame Law Review Reflection

In constitutional cases, any relevant government interest may be said to vary in its breadth or scope. Government interests can be characterized narrowly or broadly. The narrowness or breadth of how courts choose to formulate a government interest may well affect that interest’s overall weight or legal significance. For example, a public interest in safety and security, broadly conceived, may seem compelling. But the public interest in merely some modest upgrading of a safety and security regulation may seem less than compelling. A court might adopt either description. A court’s choice to characterize the government interest at stake as either …

Addressing Plastic Pollution Through Green Consumption: Predicting Intentions To Use Menstrual Cups In The Philippines, Alvin Patrick M. Valentin, Ma. Regina Hechanova-Alampay

Quantitative Methods and Information Technology Faculty Publications

Plastic pollution is a global environmental crisis that poses a huge threat to the health of people and marine ecosystems worldwide. A significant source of plastic pollution is menstrual hygiene management, and an approach that can help address this crisis is the usage of washable and reusable menstrual cups. Using an extended theory of planned behavior model that includes self-identity and perceived quality, the study predicted intentions to use menstrual cups in the Philippines. Structural equation modeling results showed that perceived quality predicted attitudes towards menstrual cup usage. Moreover, attitudes, perceived behavioral control, and self-identity predicted intentions to use menstrual …

Spontaneous Resolution Of Traumatic Bronchial Tear After Thoracic Crush Injury, Erik Schwarze, Donald D. Chang, Corbin J. Cleary, Ilya Rakitin

Surgery Articles

Traumatic bronchial tears are rare life-threatening injuries. Here, we report a 28-year old male who presented after sustaining a crush injury to his thoracic cavity, resulting in a spiral left mainstem bronchial tear secondary to high intraluminal pressure. While preparing for surgery, a preoperative bronchoscopy found that the bronchial tear had re-approximated and effectively sealed the laceration. No operative intervention was performed and the patient subsequently underwent a full recovery. While most bronchial tears undergo surgical intervention, our report describes the successful management of a bronchial tear injury with a non-operative approach and supportive care.

Foreign Direct Investment (Fdi) Role On The Economic Growth In The United Arab Emirates, Dr.Abdullah Abdelkrim Hassan

Faculty Peer-Reviewed Papers | بحوث هيئة التدريس المحكمة

Due to the recent deterioration of the global economy, economic growth (EG) has become a worldwide interest; thus, scholars must focus on this issue. Hence, this study examines the effect of FDI on the EG of the United Arab Emirates (UAE). The researchers also employed inflation, employment rate, exchange rate, and industrialization as control variables. Using the secondary data gathering approach, the researchers used the World Development Indicators (WDI) database to extract data from 1986 to 2021. The researchers additionally examine the association between variables using the Non-linear Autoregressive Distributed Lag (NARDL) technique. Results indicated that FDI, inflation, employment rate, …

Nursing And Allied Health Research Section Allied Health Librarians Survey, Michelle B. Bass, Jenn Monnin

Faculty & Staff Scholarship

In the fall of 2022, the co-authors were fortunate to be paired with one another in the MLA mentor/mentee program, Colleague Connection. Michelle, the mentor, had recently started a position as a hospital librarian and was reconnecting with her past experiences as a nursing liaison while also quickly embracing allied health liaison responsibilities. Jenn is a liaison to the allied health fields at her institution. Upon discovering this overlap, and their shared membership in NAHRS, they thought it would be informative to learn more about the liaison work of the caucus as a whole. Michelle thought it would be a …

Uc Minutes 2023-03-01, Northern Illinois University

University Council Archives

No abstract provided.

Uc Transcript 2023-03-01, Northern Illinois University

University Council Archives

No abstract provided.

Uc Agenda 2023-03-01, Northern Illinois University

University Council Archives

No abstract provided.

Utility Of Hand‑Held Ultrasound For Image Acquisition And Interpretation By Trained Kenyan Providers, Grace Wanjiku, Lindsay Dreizler, Shirley Wu, Janette Baird, Benjamin Wachira

Emergency Medicine, East Africa

Background: Point-of-care ultrasound (POCUS) plays a prominent role in the timely recognition and management of multiple medical, surgical, and obstetric conditions. A POCUS training program for primary healthcare providers in rural Kenya was developed in 2013. A significant challenge to this program is the acquisition of reasonably priced ultrasound machines with adequate image quality and the ability to transmit images for remote review. The goal of this study is to compare the utility of a smartphone-connected, hand-held ultrasound with a traditional ultrasound device for image acquisition and interpretation by trained healthcare providers in Kenya.

Methods: This study took place …

Aspirin With Or Without Statin In Individuals Without Atherosclerotic Cardiovascular Disease Across Risk Categories, Safi U. Khan, Ahmad N. Lone, Neal S. Kleiman, Adeel Arshad, Vardhmaan Jain, Mahmoud Al Rifai, Hassaan B. Arshad, Sourbha S. Dani, Amit Khera, Salim S. Virani

Office of the Provost

Background: The effects of aspirin in adults without atherosclerotic cardiovascular disease (ASCVD), stratified by statin use across different ASCVD risks, remain uncertain.
Objectives: The purpose of this study was to examine the effects of aspirin in adults without ASCVD, stratified by statin use across different ASCVD risks.
Methods: We searched databases through March 2022 and selected randomized controlled trials of aspirin without ASCVD and follow-up of ≥1 year. We used random-effects models and estimated relative and absolute risks for cardiovascular outcomes, major bleeding, and mortality over 5 years. We calculated absolute risk differences assuming constant relative risks (RRs) across statin …

Identification And Management Of Atherosclerotic Cardiovascular Disease Risk In South Asian Populations In The U.S., Anandita Agarwala, Priyanka Satish, Mahmoud Al Rifai, Anurag Mehta, Miguel Cainzos-Achirica, Nilay S. Shah, Alka M. Kanaya, Garima V. Sharma, Dave L. Dixon, Salim S. Virani

Office of the Provost

South Asians (SAs, individuals with ancestry from Bangladesh, Bhutan, India, Maldives, Nepal, Pakistan, and Sri Lanka) are among the fastest growing ethnic subgroups in the United States. SAs typically experience a high prevalence of diabetes, abdominal obesity, and hypertension, among other cardiovascular disease risk factors, which are often under recognized and undermanaged. The excess coronary heart disease risk in this growing population must be critically assessed and managed with culturally appropriate preventive services. Accordingly, this scientific document prepared by a multidisciplinary group of clinicians and investigators in cardiology, internal medicine, pharmacy, and SA-centric researchers describes key characteristics of traditional and …

Prediction Of Strawberry Yield Based On Receptacle Detection And Bayesian Inference, Sunghyun Yoon, Jung Su Jo, Steven B. Kim, Ha Seon Sim, Sung Kyeom Kim, Dong Sub Kim

Mathematics and Statistics Faculty Publications and Presentations

The receptacle of strawberry is a more direct part than the flower for predicting yield as they eventually become fruits. Thus, we tried to predict the yield by combining an AI technique for receptacle detection in images and statistical analysis on the relationship between the number of receptacles detected and the strawberry yield over a period of time. Five major cultivars were cultivated to consider the cultivar characteristics and environmental factors for two years were collected to consider the climate difference. Faster R–CNN based object detector was used to estimate the number of receptacles per strawberry plant in given two-dimensional …

"Breaking The Bank" Mergers: How Bank Consolidation Is Hurting Communities, Hannah M. Dunaway

North Carolina Banking Institute

No abstract provided.

Advanced Nursing Practice And Advanced Practice Nursing Roles Within Low And Lower-Middle-Income Countries, Andrew Scanlon, Maria Murphy, Janice Smolowitz, Virginia Lewis

School of Nursing Faculty Scholarship and Creative Works

Introduction: Population health initiatives rely on the availability and skills of an appropriate workforce to meet required goals. One global workforce initiative with demonstrated ability to expand health care services and improve access to care is the development of Advanced Nursing Practice and Advanced Practice Nursing roles. Given the sparse published information about these roles in Low and Lower-Middle-Income countries, this study seeks to describe their development and application in these countries. Design: The researchers developed a descriptive cross-sectional multilingual survey for online distribution to nursing experts within the targeted countries. Survey questions addressed demographic information on the population served, …

Masthead

The University of New Hampshire Law Review

No abstract provided.

The Grass Is Always Greener: Analyzing Crime Concentration And Specialization In Urban Greenspace Environs, Cheyenne Pamela Hodgen, Kathryn Wuschke

Criminology and Criminal Justice Faculty Publications and Presentations

Greenspaces play an important role in the urban landscape, with prior research suggesting that they are associated with numerous health and social benefits for residents. Despite this, research conflicts regarding the relationship between greenspaces and crime, with some studies finding these locations to be criminogenic and others finding them to be protective against local crime. This study examines this relationship in Portland, Oregon, considering different greenspace types as well as different crime types. Further, this study presents a novel methodological adaption to measure crime concentration and specialization around discrete location types by integrating a street network buffer into the standard …

Critical Workforce Skills For Bachelor-Level Geoscientists: An Analysis Of Geoscience Job Advertisements, Gregory W. Shafer, K. Viskupic, Anne E. Egger

Geological Sciences Faculty Scholarship

Understanding the skills bachelor-level geoscientists need to enter the workforce is critical to their success. The goal of this study was to identify the workforce skills that are most requested from a broad range of geoscience employers. We collected 3668 job advertisements for bachelor-level geoscientists and used a case-insensitive, code-matching function in Matlab to determine the skills geoscience employers seek. Written communication (67%), field skills (63%), planning (53%), and driving (51%) were most frequently requested. Field skills and data collection were frequently found together in the ads. Written communication skills were common regardless of occupation. Quantitative skills were requested less …

The Information Edge - Library Newsletter - March 2023, Sarah Burns-Feyl, Jennifer Rosenstein

University Library Newsletter

No abstract provided.

The Banner - V. 158, No. 3 - (March 2023), Christian Reformed Church In North America

The Banner

No abstract provided.

Breakthrough Sars-Cov-2 Infections Among Patients With Cancer Following Two And Three Doses Of Covid-19 Mrna Vaccines: A Retrospective Observational Study From The Covid-19 And Cancer Consortium, Toni K. Choueiri, Chris Labaki, Ziad Bakouny, Chih-Yuan Hsu, Andrew L. Schmidt, Gilberto De Lima Lopes, Clara Hwang, Sunny R. K Singh, Chinmay Jani, Lisa B. Weissmann, Elizabeth A. Griffiths, Susan Halabi, Ulysses Wu, Stephanie Berg, Timothy E. O'Connor, Trisha M. Wise-Draper, Orestis A. Panagiotou, Elizabeth J. Klein, Monika Joshi, Fares Yared, Miriam Santos Dutra, Na Tosha N. Gatson, Sibel Blau, Harpreet Singh, Rahul Nanchal, Rana R. Mckay, Taylor K. Nonato, Ryann Quinn, Samuel M. Rubinstein, Matthew Puc, Blanche H. Mavromatis, Praveen Vikas, Bryan Faller, Howard A. Zaren, Salvatore Del Prete, Karen Russell, Daniel Y. Reuben, Melissa K. Accordino, Harpreet Singh, Christopher R. Friese, Sanjay Mishra, Donna R. Rivera, Yu Shyr, Dimitrios Farmakiotis, Jeremy L. Warner

Hematology/Oncology Articles

BACKGROUND: Breakthrough SARS-CoV-2 infections following vaccination against COVID-19 are of international concern. Patients with cancer have been observed to have worse outcomes associated with COVID-19 during the pandemic. We sought to evaluate the clinical characteristics and outcomes of patients with cancer who developed breakthrough SARS-CoV-2 infections after 2 or 3 doses of mRNA vaccines.

METHODS: We evaluated the clinical characteristics of patients with cancer who developed breakthrough infections using data from the multi-institutional COVID-19 and Cancer Consortium (CCC19; NCT04354701). Analysis was restricted to patients with laboratory-confirmed SARS-CoV-2 diagnosed in 2021 or 2022, to allow for a contemporary unvaccinated control population; …

Spectator Awareness And Support Of Safety And Security Practices And Technologies During Covid-19, Stacey A. Hall, Joslyn Zale, Ryan Kavanaugh

Journal of Applied Sport Management

Since 2020, a global pandemic has challenged the sports industry in unprecedented ways; the industry came to a standstill at one point, eventually returning with limited capacities and public health safety and security precautions. This exploratory study examined spectators' awareness and level of support for general safety and security measures and their willingness to embrace COVID-19-specific policies as they returned to live events in the U.S. in 2021. A total of 609 participants who attended a professional or collegiate sporting event within the previous three years completed the survey. Results indicated that spectators considered security measures when deciding to attend …

Ace! How The Waste Management Phoenix Open Rose From The Ash Heap To Become A Sponsorship Exemplar, Lee P. Mcginnis, Keevan Statz

Journal of Applied Sport Management

Waste Management leverages the PGA TOUR’s so-called “People’s Open” in a manner that is unparalleled in the sport industry. The Waste Management Phoenix Open (WMPO) is not only a zero-waste event but also utilizes activation tactics that maximize this value proposition for consumers through sponsored activities that engage fans of all ages, backgrounds, and motivations. After an extensive analysis of the event and what makes it distinct, we propose a framework that we term ACE (Activation optimization, Cohesive value propositions, and Experientially focused programs), which can serve as a three-pronged test that event/property owners and sponsors alike can use to …

An Analysis Of Perceptions Of The Relationship Between The Athletic Director And Athletics’ Direct Reports In Ncaa Division Ii, Kelly P. Elliott, Beth Johansen, Amanda M. Siegrist

Journal of Applied Sport Management

The roles and responsibilities of the individual designated as the athletics’ direct report (ADR) on NCAA Division II member institution campuses are not clearly defined. The absence of clear guidelines creates the opportunity for differences in the relationships between the athletic director (AD) and the designated ADR between peer institutions. The purpose of this study was to explore the current relationship between ADs and ADRs and analyze current practices. Results indicated positive relations between ADs and ADRs on campus and that communication is key to a successful relationship. Recommendations for practitioners are discussed.

Advances In Cartilage Tissue Engineering Using Bioinks With Decellularized Cartilage And Three-Dimensional Printing, Roxanne N. Stone, Jonathon C. Reeck, Julia Thom Oxford

Biology Faculty Publications and Presentations

Osteoarthritis, a chronic, debilitating, and painful disease, is one of the leading causes of disability and socioeconomic burden, with an estimated 250 million people affected worldwide. Currently, there is no cure for osteoarthritis and treatments for joint disease require improvements. To address the challenge of improving cartilage repair and regeneration, three-dimensional (3D) printing for tissue engineering purposes has been developed. In this review, emerging technologies are presented with an overview of bioprinting, cartilage structure, current treatment options, decellularization, bioinks, and recent progress in the field of decellularized extracellular matrix (dECM)–bioink composites is discussed. The optimization of tissue engineering approaches using …