Digital Commons Network^™

Low Pre-Season Hamstring-To-Quadriceps Strength Ratio Identified In Players Who Further Sustained In-Season Hamstring Strain Injuries: A Retrospective Study From A Brazilian Serie A Team, Filipe Veeck, Cassio V. Ruas, Matheus Daros Pinto, Rafael Grazioli, Gustavo Pacheco Cardoso, Thiago Albuquerque, Lucas Schipper, Henrique Gonçalves Valente, Victor H. Santos, Márcio Dornelles, Paulo Rabaldo, Clarice S. Rocha, Bruno Manfredini Baroni, Eduardo Lusa Cadore, Ronei Silveira Pinto

Research outputs 2022 to 2026

A common pre-season injury prevention assessment conducted by professional football clubs is the hamstring-to-quadriceps (H:Q) strength ratio calculated by peak torque (PT). However, it is debatable whether players that present low pre-season H:Q ratios are more susceptible to further sustaining in-season hamstring strain injuries (HSI). Based upon retrospective data from a Brazilian Serie A football squad, a particular season came to our attention as ten out of seventeen (~59%) professional male football players sustained HSI. Therefore, we examined the pre-season H:Q ratios of these players. H:Q conventional (CR) and functional (FR) ratios, and the respective knee extensor/flexor PT from the …

Can We Really Say Getting Stronger Makes Your Tendon Feel Better? No Current Evidence Of A Relationship Between Change In Achilles Tendinopathy Pain Or Disability And Changes In Triceps Surae Structure Or Function When Completing Rehabilitation: A Systematic Review, Myles C. Murphy, Mervyn Travers, Paola Chivers, James Debenham, Sean I. Docking, Ebonie K. Rio, William Gibson, Clare Ardern

Research outputs 2022 to 2026

Objectives: Determine if improvements in pain and disability in patients with mid-portion Achilles tendinopathy relate to changes in muscle structure and function whilst completing exercise rehabilitation. Design: A systematic review exploring the relationship between changes in pain/disability and muscle structure/function over time, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Methods: Six online databases and the grey literature were searched from database inception to 16th December 2022 whereas clinical trial registries were searched from database inception to 11th February 2020. We included clinical studies where participants received exercise rehabilitation (± placebo interventions) for mid-portion Achilles tendinopathy if …

Lorealaus: Lorlatinib Real-World Australian Experience In Advanced Alk-Rearranged Nsclc, Marliese Alexander, Joe Wei, Sagun Parakh, Thomas John, Steven Kao, Adnan Nagrial, Samantha Bowyer, Lydia Warburton, Melissa Moore, Brett G. M. Hughes, Timothy D. Clay, Nick Pavlakis, Benjamin J. Solomon, Malinda Itchins

Research outputs 2022 to 2026

Introduction: Over the past decade, ALK tyrosine kinase inhibitors have delivered unprecedented survival for individuals with ALK-positive (ALK+) lung cancers. Real-world data enhance the understanding of optimal drug sequencing and expectations for survival. Methods: Multicenter real-world study of individuals with pretreated advanced ALK+ lung cancers managed on a lorlatinib access program between 2016 and 2020. Key outcomes were lorlatinib efficacy, tolerability, and treatment sequencing. Progression-free survival (PFS) and overall survival (OS) were calculated using the Kaplan-Meier method among all individuals (PFSa and OSa), with at least 30 days (one-cycle) lorlatinib exposure (PFSb and OSb), and with good performance status (PFSc …

Psychometric Testing Of A Danish Version Of The Empowerment Of Parents In The Intensive Care – Neonatology Questionnaire Has Confirmed Validity, Janne Weis, Sanne Allermann Beck, Andreas Jensen, Anne Brødsgaard, Jos M. Latour, Gorm Greisen

School of Nursing and Midwifery

Aim Investigating parent satisfaction with care is important to guide quality development. In this study we translated and validated a Danish version of the empowerment of parents in the intensive care – neonatology (EMPATHIC-N) questionnaire to determine validity in Danish contexts. Method A psychometric study design was applied. Translation was performed according to recommended international standards. Confirmatory factor analyses including standardized factor loadings, Cronbach's α reliability estimates, congruent validity, and nondifferential validity testing were applied. The study was performed from June 2017 through November 2019 at a 33-bed level IV neonatal intensive care unit. Results Participants were 311 parents (response …

Area Deprivation Index And Segregation On The Risk Of Hiv: A U.S. Veteran Case-Control Study, Abiodun O Oluyomi, Angela L Mazul, Yongquan Dong, Donna L White, Christine M Hartman, Peter Richardson, Wenyaw Chan, Jose M Garcia, Jennifer R Kramer, Elizabeth Chiao

2020-Current year OA Pubs

BACKGROUND: Preventing HIV infection remains a critically important tool in the continuing fight against HIV/AIDS. The primary aim is to evaluate the effect and interactions between a composite area-level social determinants of health measure and an area-level measure of residential segregation on the risk of HIV/AIDS in U.S. Veterans.

METHODS: Using the individual-level patient data from the U.S. Department of Veterans Affairs, we constructed a case-control study of veterans living with HIV/AIDS (VLWH) and age-, sex assigned at birth- and index date-matched controls. We geocoded patient's residential address to ascertain their neighborhood and linked their information to two measures of …

A Nutritional Biomarker Score Of The Mediterranean Diet And Incident Type 2 Diabetes: Integrated Analysis Of Data From The Medley Randomised Controlled Trial And The Epic-Interact Case-Cohort Study, Jakub G. Sobiecki, Fumiaki Imamura, Courtney R. Davis, Stephen J. Sharp, Albert Koulman, Jonathan M. Hodgson, Marcela Guevara, Matthias B. Schulze, Ju Sheng Zheng, Claudia Agnoli, Catalina Bonet, Sandra M. Colorado-Yohar, Guy Fagherazzi, Paul W. Franks, Thomas E. Gundersen, Franziska Jannasch, Rudolf Kaaks, Verena Katzke, Esther Molina-Montes, Peter M. Nilsson, Domenico Palli, Salvatore Panico, Keren Papier, Olov Rolandsson, Carlotta Sacerdote, Anne Tjønneland, Tammy Y. N. Tong, Yvonne T. Van Der Schouw, John Danesh, Adam S. Butterworth, Elio Riboli, Karen J. Murphy, Nicholas J. Wareham, Nita G. Forouhi

Research outputs 2022 to 2026

Background: Self-reported adherence to the Mediterranean diet has been modestly inversely associated with incidence of type 2 diabetes (T2D) in cohort studies. There is uncertainty about the validity and magnitude of this association due to subjective reporting of diet. The association has not been evaluated using an objectively measured biomarker of the Mediterranean diet. Methods and findings: We derived a biomarker score based on 5 circulating carotenoids and 24 fatty acids that discriminated between the Mediterranean or habitual diet arms of a parallel design, 6-month partial-feeding randomised controlled trial (RCT) conducted between 2013 and 2014, the MedLey trial (128 participants …

Trauma And Linguistic Markers For Symptom Severity In Prolonged Exposure For Primary Care, As Observed Through The Use Of Narrative Review, Robert Alexander Ryan

Theses and Dissertations

Traditional trauma therapies used in the primary care setting (e.g., hospital, medical clinic, etc.) have posed challenges to patient success because they are not designed for the shorter duration treatment that is typical in primary care settings. One alternative solution is the Prolonged-Exposure for Primary Care protocol (PE-PC) that utilizes prolonged exposure using a brief take home assignment and several journaling prompts that are processed using principles from Cognitive Processing Therapy (CPT). Still in its early stages of development, the PE-PC protocol can provide symptom relief in as little as four, 30-minute sessions and reflects one of the first trauma …

A Mixed Methods Sequential Explanatory Design Study Exploring How Demographic Factors Contribute Individuals Presenting To The Emergency Department For Seizure Management, Radwa Aly Msc

Doctor of Philosophy in Translational Health Sciences Dissertations

Psychogenic nonepileptic seizures (PNES) mimic epileptic seizures in their clinical manifestations, but are not associated with an abnormal electrical discharge on electroencephalogram. PNES attacks are often treated and managed as likely epileptic seizures, subjecting the patient to unnecessary anti-seizure medications (ASM). Both epileptic seizures and PNES are common reasons for visiting the emergency department (ED), especially for patients without access to ambulatory care. There is growing evidence highlighting disparities in seizure care in the ED related to race, ethnicity, and socioeconomic status (SES). PNES is a significant burden to the patient and society because of the annual costs spent on …

“Do You Think This Is Not Happening?”: Rhetorical Laundering And The Federal Hearings Over Planned Parenthood, Calvin R. Coker

Faculty and Staff Scholarship

This essay offers a rhetorical reading of Congressional hearings investigating the Center for Medical Progress’s (CMP’s) videos falsely accusing Planned Parenthood of selling fetal tissue. Despite the suspect nature of the allegation at the time it was levied, and subsequent investigations rejecting the CMP’s claims, the notion that Planned Parenthood profits from the sale of fetal tissue has persisted alongside accelerated antiabortion jurisprudence and vitriolic rhetoric. This acceleration and persistence may be the result of what I term “rhetorical laundering” wherein suspect evidence is justified as worthy of study in a credible public forum, only to have its treatment in …

The Downfall Of Women’S Reproductive Health, Hailey Reel

Undergraduate Research Conference

No abstract provided.

Reproductive Health In America: A History Of Patriarchal Control, Hailey Mccool

Undergraduate Research Conference

The United States is often referred to as the land of opportunity and the home of the free, yet today, those who challenge the patriarchal system are not treated fairly or equitably. Historically, from owning land to voting women have fought for the same rights enjoyed by men. The effort of early feminist movements paved the way for the Supreme Court to protect women’s reproductive rights through Roe v. Wade. For decades, women were able to make a choice regarding their reproductive health. However, in just the past year (2022), the Supreme Court ruled to strike down Roe v. …

Efficacy Of Trauma Informed Care In Reducing Anxiety And Depressive Symptoms Among Patients On Medication Assisted Therapy For Opioid Use Disorder: A Randomised Control Trial, John Akinbote

Research Days

Authors:

John Akinbote

Kibble Courtney

Jesus Reyes

William Matallana

Veronica Cardenas



The concept of trauma-informed care (TIC) has been over flogged in the traditional healthcare settings of patients with mental disorders with some success but there is a need to ascertain its impact amongst patients in recovery for drug addiction. It is pertinent to state that patients with early life adverse childhood events (ACEs), ongoing stressors and significant life events remain vital targets of trauma -related diagnostic entities since these factors play role in predicting the predisposing, precipitating and perpetuating factors in the dynamics of opioid use disorder and other …

Antagonistic Pleiotropy In Alzheimer's Disease, Annie Hollis

Undergraduate Research Conference

Apolipoprotein E (APOE) ε4 allele has been linked with Alzheimer’s disease; specifically having two copies of the APOE ε4 allele greatly increases the risk of developing Alzheimer’s disease in older age. Studies have attempted to relate an antagonistic pleiotropy hypothesis to this gene, i.e., the ε4 allele has positive effects on cognition and memory in early life and negative effects later in life. Many of these studies have had several limitations and conflicting results, such as testing adults in upper middle age or comparing the absence of the ε4 allele with the presence of at least one ε4 allele. Studies …

Covid-19 Vaccine Anxiety In The New Roaring 20s’, Sana S. Mahar

Research Days

Over the last two years, the discussion on vaccines has grown exponentially. The decision to be vaccinated, while to some is a “no brainer”, is now a debatable topic. The purpose of this presentation is to investigate some of the root causes for vaccine anxiety in the last two years. For this analysis, I will use reputable media sources to identify vaccine anxiety references within political, medical, and social media contexts and the types of anxiety conveyed; namely fear, anxiety, and distrust within vaccines. Politically in the last 2 years, Donald Trump’s ideologies of the danger of vaccinations lead to …

Ways That Nutrition Can Improve Mental And Physical Well-Being, Will Ravetto

Research Days

People are searching for things to do to help themselves feel their best. No matter if its to have energy to get you through the day or to do well on a big test or activity it all starts with what we eat to help us conquer every day. My research dives into the multiple food groups and concepts that create one’s diet. Exploring accessible nutritional foods that will improve immune health and longer lasting energy. This includes foods that aid recovery such as proteins, amino acids and even carbohydrates. I also, discourage foods one should stray away from like …

What's Your Biggest Secret?, Emely M. Oviedo, Sydney B. Snapp, George Kazanecki

Research Days

Initial study (e.g., Kahneman & Tversky, (1982) has indicated that failed actions (i.e., switches that result in negative outcomes) evoke more regret than inactions (i.e., non-switches resulting in negative outcomes), a vigorous finding in the regret literature. Subsequent work, however, revealed that individuals report more inaction regrets than action regrets (e.g., Gilovich & Medvec, 1994). The current research examines whether regret stemming from actions versus inactions are moderated by one’s attachment style. Attachment can be both crucial when it comes to decision making and one’s ability to mitigate the negative effects following a decision. Participants will be asked to complete …

The Effects Of Mindfulness On Regret: An Explorative Analysis, Emely M. Oviedo, Sydney B. Snapp, George Kazanecki, Timothy Pedigo Ph.D, Figen Karadgon Ph.D

Research Days

Regret has been found to be associated with anxiety, depression, and cognitive distortions (Markman et al., 2009; Markham & Miller, 2006). In relation to regret, past actions and decisions create painful experiences resulting in negative rumination (Olatunji et al., 2013). However, if the negative rumination is reduced there is the potential to learn important feedback from previous decisions that have resulted in painful experiences. Thus, the current research explores the mitigating role of mindfulness on the amount of regret experienced. It was hypothesized that the participants would report experiencing less amount of regret following mindfulness meditation. First, participants were asked …

Sexual Knowledge And Wellness Of College Students, Aubrey Parker

Undergraduate Research Conference

Abstract: The purpose of this research project is to conduct further research on the use of a questionnaire developed by the fall 2022 FSC 330 class to assess sexual health knowledge of W students. I plan to study their use as a potential educational tool to provide sexual health knowledge to W students in addition to assessing their sexual health knowledge. The revised survey consists of topics that cover: contraceptives, women’s/ men’s sexual health and anatomy, gender/ sexual orientation, sexual coercion, STI’s, and lastly love/ communication. The survey we are currently making will have three different versions that are: feedback …

Phage Peptide Technology To Characterize Extracellular Vesicles In The Brain Tumors, Jadelynn Rudolf

Undergraduate Research Conference

Extracellular vesicles (EV) are lipid-bound containers derived from the endosomal membrane network or from the extracellular membrane of cells. They can carry proteins, lipids, miRNAs, and other molecules, and may be involved in intercellular communication via membrane-associated proteins. Glioblastomas (GBM) are aggressive cancers of the brain and spinal cord derived from astrocytes. Extracellular vesicles derived from glioblastomas can make their way through the blood brain barrier and find their way to different bodily fluids, and so could serve as biomarkers for this cancer. We have isolated phage-display peptides from a commercial library of random phage-displayed peptides that will bind glioblastoma …

Computational Evaluation Of Bioactive Compounds From Vaccinium Vitis-Idaea L (Ligonberry) For Treating Kras-Associated Lung Cancer, Ayooluwa Ilesanmi, Gbenga Dairo, Toheeb Balogun, Bibiire Awoyale

Undergraduate Research Conference

Lung cancer is the cancer of the lung's epithelial cells typically characterized by difficult breathing, chest pain, blood-stained coughs, headache, and weight loss. If left unmanaged, lung cancer can spread to other body parts. While several treatment methods exist for managing lung cancer, exploring natural plant sources for developing therapeutics offers great potential in complementing different treatment approaches. In this study, we concentrated on inhibiting the mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) by targeting an associated protein (Phosphodiesterase 6δ) to which KRAS form complexes. We evaluated bioactive compounds from Lingonberry (Vaccinium vitis-idaea L), adopting computational approaches such as …

Triazole Compounds – Potentials In The Treatment Of Cystic Fibrosis, Maggie Taylor

Undergraduate Research Conference

Cystic Fibrosis (CF) is a genetic disease that affects the respiratory and digestive system and is most common among Caucasians of Northern European origin. CF is caused by mutations in a membrane protein CFTR (Cystic Fibrosis Transmembrane-conductance Regulator). This mutation impairs the membrane protein’s chloride ion channel function. One of the most common CFTR mutations is the DF508 mutation that affects over 70% of CF cases. Our research has shown that the DF508-CFTR mutation can be partially reversed by physical and chemical means [Heda & Marino, BBRC, 271:659-664, 2000]. In cell lines expressing DF508-CFTR, synthetic anion carriers have shown to …

How Technology May Be Used For Future Disease Prediction: A Systematic Literature Review, Rich P. Manprisio, Mohammed Salam

Research Days

Exasperated by the current pandemic, our healthcare system continues to struggle with the accuracy and effectiveness of disease treatments. However, despite these growing challenges, technological advancements have aided potential disease prediction. There has been a positive correlation between utilizing technologies and leveraging them for disease predictions. Thanks to our continued reliance and technological advancement, current research shows that it has many viable options to aid the healthcare field. This systematic review looks at the current state of how technologies have been and can be used to improve healthcare.

The Effects Of Eye Pressure And Diabetes On Vision, Rinsa Reji

Research Days

Vision is the primary sense that allow us to connect with the world. The optic nerve contains millions of nerve fibers that send visual messages to the brain which enables vision. The optic nerve is located at the back of each eye and connects directly to the brain. The optic nerve can be damaged due to high eye pressure and the condition is known glaucoma. The high eye pressure or intraocular pressure increases when the flowing fluid inside the eyes, also known as aqueous humor, builds up instead of draining out. The aqueous humor usually drains through the tissue called …

Parental Involvement In Urban Schools, Tiffany M. Weathers-Fincher

Research Days

Parental involvement continues to decline in urban schools, and their engagement is critical to closing growing educational gaps. As a result, this research aims to explore the perceptions of elementary school principals and teachers and parents' experiences relating to promoting parental involvement. The researcher examined existing research to explore this topic and utilized Epstein's Theory of Overlapping Spheres of Influence, commonly used to study family involvement within schools. Research suggests that the participation of parents is at the core of student academic success, and the lack thereof is a consequence of the disconnection of the spheres of influence, which are …

Py-05 Pediatric Vehicular Heatstroke: Analysis Of Cases That Children Gained Access To Vehicle, Emily N. Krull, Jennifer Gray Phd

SC Upstate Research Symposium

Since 1998, 937 children have died from Pediatric Vehicular Heatstroke (PVH), while this number is small regarding childhood mortality, it is still an important concern because the deaths of these children could have been prevented. Previous research has analyzed the deaths that occurred when children were left in the vehicle knowingly and unknowingly but does not discuss the cases where children gained access to the vehicle. The goal of this research is to determine what went wrong in the cases where children gained access to the vehicle and what parents were doing at the time of the incident, to understand …

Up-05 Comparing The Effects Of Pharmacological And Demographic Factors Between Male And Female Patients Diagnosed With Late-Onset And Early-Onset Alzheimer's Disease., Alyssa G. Miller, Thomas Nathaniel

SC Upstate Research Symposium

Objective: The current study investigates differences in men and women patients with Late-onset Alzheimer’s disease (LOAD) and Early-onset Alzheimer’s disease (EOAD)using pharmacological and demographic factors.

Method: Data for this study was collected from the Prisma Health Upstate Alzheimer’s patients registry between 2016-2021. Multivariate analysis was used to predict specific pharmacological and demographic factors associated with men and women with LOAD and EOAD.

Results: A total of 91.7% LOAD and 8.3% EOAD patients were identified. In the adjusted analysis, men AD patients that were administered memantine [OR=1.588, 95% CI, 1.175-2.145, p=0.003], and buspirone [OR = 1.971, 95% CI, 1.221-3.183, p=0.006] …

Be-03 Effects Of Dietary Iron On Taxonomic Composition And Function Of The Zebrafish Gut Microbiome, Megan D. Whisonant, Jeremiah L. Jackson, Sam L. Evans, Stuart Gordon Ph.D.

SC Upstate Research Symposium

A healthy gut microbiota is essential to promote host health and well-being, therefore, effects of dietary components on the gut microbiome are important to investigate as the gastrointestinal tract can be a major route of infection. Iron—an essential component of heme and iron-sulfur proteins—plays a central role in many biological activities, including oxygen transport and cellular respiration.

In particular, the iron homeostasis system is one of the best characterized due to iron's causative relationship with iron-deficiency anemia. Dietary iron supplementation is a commonly used treatment for iron deficiency anemia; however, the known direct impacts of iron on the gut microbiome …

Bm-01 Marketing Research Tutoring Center, Roger Brian Herrera, Zachary Jennings, Shamarion C. Tubbs, Christina A. King-Johnson

SC Upstate Research Symposium

Marketing Research Tutoring Center

Spartanburg Methodist College is interesting in determining the perceived effectiveness of their tutoring center from both the students and faculty perspectives. There is a focus on ude the integration of drop-in tutoring, commuter culture and involvement, invested time results, students with time conflicts, and Intelligent Tutoring Systems.

Altogether, these subjects represent attributing factors that can help better understand the research question: Are there any issues that exist with our tutoring center that need to be addressed to increase attendance? For instance, with topics such as drop-in tutoring it was stated that attendance rates were increased and …

Bm-02 Spartanburg Methodist College: Evaluation Of Classroom Space Efficiency, Kahleag D. Terry, Drake A. Taber, Christina King-Johnson

SC Upstate Research Symposium

Spartanburg Methodist College: Evaluation of Classroom Space Efficiency

In 2019, Spartanburg Methodist College converted from a two-year to a four-year institution. As the college grows, more classrooms are needed to satisfy the course requirements for students. A research study was conducted to answer the following question: What is the best option to implement additional class times/locations for traditional undergraduate students for both student and faculty.

Through out the semester, the student researchers analyzed various types of data address the problems of space and later class time allocation opportunities. An evaluation of the last eight semesters class location and times were …

Es-03 The Effects Of A Warmup Protocol Involving The Nordic Hamstring Exercise On Vertical Squat Jump Performance And Peak Muscular Activation, Reagan Hunter, Jeff Barfield

SC Upstate Research Symposium

Background: Vertical jumping is one of the most popular ways of assessing athleticism and power output of the lower body in both professional and recreational sport settings. Therefore, having access to an appropriate warmup protocol for enhancing this skill and the power output associated with it is essential for athletes whose success depends on the ability to perform it. Current literature demonstrates similar posterior kinetic chain muscle engagement during the vertical squat jump and during an exercise called the Nordic Hamstring Curl. The literature additionally demonstrates significant effects on strength and athleticism when the exercise is used in long-term training …