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The Free Press Vol. 54, April 04-17-2023, Cullen Mcintyre

Free Press, The

Eurydice Rises Through Adversity--Weed and it's Wonders--Credit Scores--Asylum Seekers Arrive in Portland--Usm's First Annual Week of Pride--Russel Scholars and Kids' Poems--The Textbooks on Reserve Program: Free Textbooks for Students

Cancer Cell-Extrinsic Roles For The Androgen Receptor In Prostate Cancer, Andrew W Hahn, Bilal A Siddiqui, Javier Leo, Eleonora Dondossola, Kaitlin J Basham, Cindy K Miranti, Daniel E Frigo

Faculty, Staff and Student Publications

Given the central role of the androgen receptor (AR) in prostate cancer cell biology, AR-targeted therapies have been the backbone of prostate cancer treatment for over 50 years. New data indicate that AR is expressed in additional cell types within the tumor microenvironment. Moreover, targeting AR for the treatment of prostate cancer has established side effects such as bone complications and an increased risk of developing cardiometabolic disease, indicating broader roles for AR. With the advent of novel technologies, such as single-cell approaches and advances in preclinical modeling, AR has been identified to have clinically significant functions in other cell …

Stranger Things: New Roles And Opportunities For Androgen Receptor In Oncology Beyond Prostate Cancer, Javier Leo, Eleonora Dondossola, Kaitlin J Basham, Nathaniel R Wilson, Omar Alhalabi, Jianjun Gao, Katherine C Kurnit, Michael G White, Jennifer L Mcquade, Shannon N Westin, Elizabeth A Wellberg, Daniel E Frigo

Faculty, Staff and Student Publications

The androgen receptor (AR) is one of the oldest therapeutic targets in oncology and continues to dominate the treatment landscape for advanced prostate cancer, where nearly all treatment regimens include some form of AR modulation. In this regard, AR remains the central driver of prostate cancer cell biology. Emerging preclinical and clinical data implicate key roles for AR in additional cancer types, thereby expanding the importance of this drug target beyond prostate cancer. In this mini-review, new roles for AR in other cancer types are discussed as well as their potential for treatment with AR-targeted agents. Our understanding of these …

Ether Phospholipids Are Required For Mitochondrial Reactive Oxygen Species Homeostasis, Ziheng Chen, I-Lin Ho, Melinda Soeung, Er-Yen Yen, Jintan Liu, Liang Yan, Johnathon L Rose, Sanjana Srinivasan, Shan Jiang, Q Edward Chang, Ningping Feng, Jason P Gay, Qi Wang, Jing Wang, Philip L Lorenzi, Lucas J Veillon, Bo Wei, John N Weinstein, Angela K Deem, Sisi Gao, Giannicola Genovese, Andrea Viale, Wantong Yao, Costas A Lyssiotis, Joseph R Marszalek, Giulio F Draetta, Haoqiang Ying

Faculty, Staff and Student Publications

Mitochondria are hubs where bioenergetics, redox homeostasis, and anabolic metabolism pathways integrate through a tightly coordinated flux of metabolites. The contributions of mitochondrial metabolism to tumor growth and therapy resistance are evident, but drugs targeting mitochondrial metabolism have repeatedly failed in the clinic. Our study in pancreatic ductal adenocarcinoma (PDAC) finds that cellular and mitochondrial lipid composition influence cancer cell sensitivity to pharmacological inhibition of electron transport chain complex I. Profiling of patient-derived PDAC models revealed that monounsaturated fatty acids (MUFAs) and MUFA-linked ether phospholipids play a critical role in maintaining ROS homeostasis. We show that ether phospholipids support mitochondrial …

Distinct Astrocytic Modulatory Roles In Sensory Transmission During Sleep, Wakefulness, And Arousal States In Freely Moving Mice, Fushun Wang, Wei Wang, Simeng Gu, Dan Qi, Nathan A Smith, Weiguo Peng, Wei Dong, Jiajin Yuan, Binbin Zhao, Ying Mao, Peng Cao, Qing Richard Lu, Lee A Shapiro, S Stephen Yi, Erxi Wu, Jason H Huang

Faculty, Staff and Student Publications

Despite extensive research on astrocytic Ca2+ in synaptic transmission, its contribution to the modulation of sensory transmission during different brain states remains largely unknown. Here, by using two-photon microscopy and whole-cell recordings, we show two distinct astrocytic Ca2+ signals in the murine barrel cortex: a small, long-lasting Ca2+ increase during sleep and a large, widespread but short-lasting Ca2+ spike when aroused. The large Ca2+ wave in aroused mice was inositol trisphosphate (IP3)-dependent, evoked by the locus coeruleus-norepinephrine system, and enhanced sensory input, contributing to reliable sensory transmission. However, the small Ca2+ transient was IP3-independent and contributed to decreased extracellular K+, …

The Effects Of Creatine Monohydrate Supplementation On Anaerobic Performance, Ava G. Swart

Celebrating Scholarship and Creativity Day (2018-)

Multiple studies have been conducted on the effect of creatine monohydrate supplementation on muscular strength. However, evidence of the effect of creatine supplementation on anaerobic performance is less clear. PURPOSE: To determine if creatine supplementation impacts sprint speed and vertical jump height. METHODS: 10 females and 9 males (N=19) aged 21 ± 0 from the College of Saint Benedict and Saint John’s University participated in this randomized single blind study. Participants ingested creatine monohydrate or a placebo for 21 days and were tested on days 1, 6, 14, and 21. Day one tests were completed prior to the consumption of …

Employment Research, Vol. 30, No. 2, April 2023

Employment Research Newsletter

No abstract provided.

Intouch Week Of April 17, 2023, New York Medical College

InTouch

• Notable Commencement Speakers Set to Address the Class of 2023
• First-Year Gross Anatomy Experience Yields Publications for SOM Students
• Neil Schluger, M.D., Marks Milestone in Treating Pulmonary Disease in Africa
• Center for Disaster Medicine Hosts Two-Day CBRNE Training
• NYMC Goes All In For FIMO’s Spring Food Drive

Promote Service Learning, Yoshihiko Ariizumi

Spiritual Proficiency

Service-oriented efforts are critical for college students' optimal growth intellectually, emotionally and spiritually.

No Refuge From The Fields Vol. 2: Revitalization Of Farmworker Housing Research, Manda Laporte

Capstone Projects – Politics and Government

Farmworkers in the U.S. are often subjected to substandard living situations. However, since they are primarily seasonal, migrant, or temporary work visa holders, limited attention is focused on their quality of life. Although farmworkers are some of the hardest working people, they are typically exposed to extreme weather and working conditions, have the highest percentage of people among the working poor, face restrictive access to education and health care, etc. While service providers, such as housing developers and healthcare specialists, are concerned about these individuals’ well-being, there is still minimal research available about current farmworker trends. This report seeks to …

Neurofibroma Of The Internal Carotid Artery Cavernous Sympathetic Plexus: Illustrative Case, Duncan J Trimble, Bryden H Dawes, Hussein A Zeineddine, Katie B Guttenberg, William C Yao, Meenakshi Bhattacharjee, Spiros L Blackburn

Faculty, Staff and Student Publications

BACKGROUND: Intracranial carotid sympathetic plexus (CSP) nerve sheath tumors have rarely been reported in the literature. This study describes the first reported case of a CSP neurofibroma and the first case of a CSP nerve sheath tumor treated via an endoscopic endonasal approach followed by adjuvant radiosurgery.

OBSERVATIONS: A 53-year-old man presented with 3 days of headaches and diplopia and was found to have a complete left abducens nerve palsy. Computed tomography (CT) revealed a smoothly dilated left carotid canal, CT angiography revealed a superiorly displaced left internal carotid artery (ICA), and magnetic resonance imaging revealed a T2-hyperintense and avidly …

Embodied, Simulation-Based Cognition: A Hybrid Approach, Sean Christopher Kugele

Electronic Theses and Dissertations Archive

Embodied cognition is a paradigm in cognitive science that emphasizes the fundamental role of bodies, environmental interactions, situational contexts, and sensory and motor systems in cognitive processing. Much of the research in embodied cognition has focused on online cognitive activities (such as reactive, overt behaviors) that are directly coupled to environmental stimuli. Such research fails to explain offline cognitive activities (such as planning, deliberation, and mental imagery) that are spatially or temporally decoupled from one’s immediate sensory experiences. Embodied, simulation-based theories of cognition attempt to address this shortcoming by proposing a mechanism—modal simulations—by which sensory and motor systems can directly …

Gbc: A Parallel Toolkit Based On Highly Addressable Byte-Encoding Blocks For Extremely Large-Scale Genotypes Of Species, Liubin Zhang, Yangyang Yuan, Wenjie Peng, Bin Tang, Mulin Jun Li, Hongsheng Gui, Qiang Wang, Miaoxin Li

Behavioral Health Articles

Whole -genome sequencing projects of millions of subjects contain enormous genotypes, entailing a huge memory burden and time for computation. Here, we present GBC, a toolkit for rapidly compressing large-scale genotypes into highly addressable byte-encoding blocks under an optimized parallel framework. We demonstrate that GBC is up to 1000 times faster than state-of-the-art methods to access and manage compressed large-scale genotypes while maintaining a competitive compression ratio. We also showed that conventional analysis would be substantially sped up if built on GBC to access genotypes of a large population. GBC's data structure and algorithms are valuable for accelerating large-scale genomic …

Impact Of Global Warming On The Severity Of Viral Diseases: A Potentially Alarming Threat To Sustainable Aquaculture Worldwide, Marine Combe, Miriam Reverter, Domenico Caruso, Elodie Pepey, Rodolphe Elie Gozlan

School of Biological and Marine Sciences

With an ever-increasing human population, food security remains a central issue for the coming years. The magnitude of the environmental impacts of food production has motivated the assessment of the environmental and health benefits of shifting diets, from meat to fish and seafood. One of the main concerns for the sustainable development of aquaculture is the emergence and spread of infectious animal diseases in a warming climate. We conducted a meta-analysis to investigate the influence of global warming on mortality due to viral infections in farmed aquatic animals. We found a positive trend between increasing temperature and increasing viral virulence, …

The Current State Of Healthcare In The United States: Barriers To Healthcare, Quality Of Care, And Self-Reported Health, Lauren Ashley Robinson Williams

Electronic Theses and Dissertations Archive

A primary goal of the Affordable Care Act (ACA) was to increase health insurance coverage, reduce health care costs, and improve quality of care. Insurance coverage expanded, however, the effect of the ACA on barriers to accessing care and quality of care is less apparent. Outcome variables related to barriers (having a usual source of care, delaying care due to cost, forgoing care due to cost) and quality (whether healthcare providers always: showed respect, spent enough time listened, explained; and an overall rating of providers) from the Medical Expenditure Panel Survey (MEPS) were examined to evaluate whether barriers to healthcare …

Stretchable Sensors For Soft Robotic Grippers In Edge-Intelligent Iot Applications, Prosenjit Kumar Ghosh, Prabha Sundaravadivel

Electrical Engineering Faculty Publications and Presentations

The rapid development of electronic material and sensing technology has enabled research to be conducted on liquid metal-based soft sensors. The application of soft sensors is widespread and has many applications in soft robotics, smart prosthetics, and human-machine interfaces, where these sensors can be integrated for precise and sensitive monitoring. Soft sensors can be easily integrated for soft robotic applications, where traditional sensors are incompatible with robotic applications as these types of sensors show large deformation and very flexible. These liquid-metal-based sensors have been widely used for biomedical, agricultural and underwater applications. In this research, we have designed and fabricated …

Fatty Acid, Carotenoid And Fat-Soluble Vitamin Composition Of Multispecies Swards Grown In Ireland—Implications For A Sustainable Feed In Dairy Farming, Samuel Rapisarda, Graham O'Neill, Nissreen Abu-Ghannam

Articles

Although traditional ryegrass pastures are still commonly used, they require intense management and input and do not perform well during the summer months. Multispecies systems have been recognised as more sustainable, needing less fertiliser and being tolerant to drought and heat. While data on monoculture system fat composition exist, information for multispecies is scarce. The present study compared the fatty acid (FA), carotenoid and fat-soluble composition of a multispecies system (consisting of perennial ryegrass, timothy, white clover, red clover, chicory and plantain) (MULTI) with two other conventional grazing systems (monoculture perennial ryegrass (PRG) and a binary mixture of perennial ryegrass …

Ndls Communicator: Week Of 04.17.23, Notre Dame Law School

NDLS Communicator

The Latest News

• Marcus Cole was one of the keynote speakers at the 10th annual Iowa Religious Freedom Day. He spoke about the value of religious freedom in society.
• Nicole Garnett and Meredith Kessler wrote an op-ed for the Wall Street Journal.
• Mary Ellen O'Connell was one of the Notre Dame experts who talked to ND News about the recent attention toward Taiwan and its impact on U.S.-China relations.
• Nicole Garnett was quoted in the New York Times article, "Nation’s First Religious Charter School Could Be Coming to Oklahoma."
• Jeff Pojanowski spoke about "Enduring Originalism’ and common law constitutionalism at …

Approval For: Draft Final Fourth Quarter 2022, Operations & Maintenance Monitoring Report For The Rocker Timber Framing And Treating Plant Operable Unit; Dated January 10, 2023., Nikia Greene

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Lysosomal Lipid Peroxidation Regulates Tumor Immunity, Monika Bhardwaj, Jennifer J Lee, Amanda M Versace, Sandra L Harper, Aaron R Goldman, Mary Ann S Crissey, Vaibhav Jain, Mahendra Pal Singh, Megane Vernon, Andrew E. Aplin, Seokwoo Lee, Masao Morita, Jeffrey D Winkler, Qin Liu, David W Speicher, Ravi K Amaravadi

Department of Surgery Faculty Papers

Lysosomal inhibition elicited by palmitoyl-protein thioesterase 1 (PPT1) inhibitors such as DC661 can produce cell death, but the mechanism for this is not completely understood. Programmed cell death pathways (autophagy, apoptosis, necroptosis, ferroptosis, and pyroptosis) were not required to achieve the cytotoxic effect of DC661. Inhibition of cathepsins, or iron or calcium chelation, did not rescue DC661-induced cytotoxicity. PPT1 inhibition induced lysosomal lipid peroxidation (LLP), which led to lysosomal membrane permeabilization and cell death that could be reversed by the antioxidant N-acetylcysteine (NAC) but not by other lipid peroxidation antioxidants. The lysosomal cysteine transporter MFSD12 was required for intralysosomal transport …

Feasibility Study Of Cord Tissue Derived Mesenchymal Stromal Cells In Covid-19-Related Acute Respiratory Distress Syndrome, Khalid Hanafy, Margaret Scott, Ralph Palumbo, Frank Vrionis

All Publications

Background: Treatment options for patients with COVID-19-related acute respiratory distress syndrome (ARDS) are desperately needed. Allogeneic human umbilical cord derived mesenchymal stromal cells (hCT-MSCs) have potential therapeutic benefits in these critically ill patients, but feasibility and safety data are lacking.

Materials and methods: In this phase I multisite study, 10 patients with COVID-19-related ARDS were treated with 3 daily intravenous infusions of hCT-MSCs (1 million cells/kg, maximum dose 100 million cells). The primary endpoint assessed safety.

Results: Ten patients (7 females, 3 males; median age 62 years (range 39-79)) were enrolled at 2 sites and received a total of 30 …

Climate Change, Site Formation, And Indigenous Use Of Coastlines In Barbuda, Isabel C. Rivera-Collazo, Sophia Perdikaris

School of Global Integrative Studies: Faculty Publications

This article explores the landscape dynamics at the island of Barbuda in the context of changing climate to understand (1) the environmental setting of indigenous settlements; (2) the impacts of current coastal processes; and (3) the potential threats moving forward toward increasing pressure of climate change. Focusing on the site of Seaview, on the east coast of Barbuda, we use geoarchaeological methods to reconstruct the ancient geomorphological setting, investigate changes post-abandonment, and identify the hazards faced under future sea-level projections. Our study shows that (1) sea level stabilization after the Mid-Holocene allowed the formation of coral reefs, seagrass beds and …

Cardozo’S Criminal Defense Clinic Wins Commuted Sentence For N.Y. Man Serving One Of The Longest Prison Terms Under Rockefeller Drug Laws, Benjamin N. Cardozo School Of Law

Cardozo News 2023

Cardozo School of Law’s student Criminal Defense Clinic attained clemency for Joaquin Winfield on April 7 from New York Gov. Kathy Hochul.

Not In This House, Satan! An Integrative Framing Analysis Of Body-Positive Posts On Instagram, Gladys Mana Momade

Theses and Dissertations

Scholars have associated the portrayal of idealized images of the body on social media with the negative body image of users, which manifests as several mental health problems such as eating disorders, body dissatisfaction, body dysmorphic disorder, depression, and anxiety in users. To tackle this issue, body-positive (BoPo) influencers on Instagram, having achieved a state of positive body image, post verbal and visual messages to advocate against normative ideologies that foster the negative body image of social media users. These messages have some implications for health communication and body image research. This study analyzes body-positive influencers’ self-assertion and self-expression in …

Revolutionize Respiratory Disease Treatment Using A Smart Dry Powder Inhaler, Mohammad Razmjoo, Taylor Gatten, Chad Sherwood, Jorell Phillips, Wilson Ramirez, Joshua Nguyen, Steven Santillan, Bryce Roberts, Amelia Bierle, Christian Slough, Dominic Thompson, Nathan Jackson, Pavan Muttil

Annual Research & Scholarship Day

No abstract provided.

College Of Pharmacy Research & Scholarship Day 2023 Booklet, Becky Woloszyn, Jose Rodriguez

Annual Research & Scholarship Day

No abstract provided.

Research At The University Of New Mexico College Of Pharmacy (Unm Cop) - A Five-Year Overview, Rebecca L. Woloszyn, Luke Latterell

Annual Research & Scholarship Day

No abstract provided.

Overcoming Barriers Of Vaccination Against Malaria Using Microneedles And Trio, Aidan L. Leyba, Mohammad Razmjoo, Alexandra Francian, Amelia Bierle, Bryce Roberts, Lucie Jelinkova, David A. Mcchesney, Shintaro Fumoto, Bryce Chackerian, Pavan Muttil

Annual Research & Scholarship Day

No abstract provided.

Inhaled Microbiomics, Pharmaceutical Formulation And Disease Considerations In Patients With Cystic Fibrosis, David A. Mcchesney, Aidan Leyba, Mohammad Razmjoo, Pavan Muttil

Annual Research & Scholarship Day

No abstract provided.

Heart Attack To Hypoxic Ischemic Brain Injury, Tiffany M. Tafoya, Evelyn Pinto, Jessica Cordova

Client Educational Handouts

Occupational therapist play a huge role in the rehabilitation and well-being of individuals who suffer brain injuries. Decline of cognition, endurance, balance, and short-term memory loss are areas an occupational therapist can address in therapy. Therapy will help the individual become more independent and regain function.