Digital Commons Network^™

Multi-Organ Physiologic Deficits During Exercise Identify Clinical And Molecular Predisposition To Heart Failure With Preserved Ejection Fraction, Isabela Landsteiner, Lindsey K Stolze, Tess E Peterson, Andrew Perry, Phillip Lin, Quanhu Sheng, Shilin Zhao, Kaushik Amancherla, Michael Y Mi, Takenori Ikoma, Laura P Cohen, Ilya Giverts, Joseph Campain, Joao A C Lima, Wendy S Post, Kent D Taylor, Robert Gerszten, Stephen S Rich, Russell Tracy, Peter Durda, Alexis C Wood, Rajeev Malhotra, Jerome I Rotter, Clary Clish, Matthew Nayor, Eric R Gamazon, Ravi V Shah, Gregory D Lewis

Faculty, Staff and Students Publications

Background: Exercise unmasks limitations in multi-organ system reserve capacity characteristic of heart failure with preserved ejection fraction (HFpEF). However, the metabolic and genetic underpinnings of exercise deficits, and their cumulative contribution to HFpEF severity and prognosis, remain incompletely understood.

Methods: We used invasive cardiopulmonary exercise testing (iCPET), metabolite profiling, and genomics to simultaneously characterize seven exercise physiologic deficits in HFpEF patients: reduced exercise stroke volume and heart rate, steep pulmonary capillary wedge pressure/cardiac output (PCWP/CO) slope, elevated pulmonary vascular resistance, pulmonary mechanical limitation to exercise, impaired peripheral oxygen extraction, and obesity-related exaggerated metabolic cost of initiating exercise. We first mapped …

Structure-Preserving Multivariate Hypothesis Testing For Mass Spectrometry Imaging And Single-Cell Data, Keziah E Liebenberg, Erin Craig, Robert Tibshirani, Livia S Eberlin

Faculty, Staff and Students Publications

Motivation: Mass spectrometry imaging (MSI) and single-cell RNA sequencing (scRNA-seq) offer high-resolution views into tissue and cellular heterogeneity. However, conventional statistical analyses often treat sub-measurements (pixels or cells) as independent, ignoring their nested origin from individual samples. This assumption inflates the effective sample size, increases false discoveries, and undermines biological interpretation. Pixel- or cell-level averaging avoids this but sacrifices spatial or cellular resolution.

Results: We evaluated block-SAM on both simulated and real-world datasets. In DESI-MSI data from kidney, lung, and ovarian tumors, block-SAM consistently identified fewer-but more reliable-differential features compared to traditional-SAM. For example, in the kidney dataset, traditional-SAM identified …

Editorial: Publishing Impact Awarded, Frazer Underwood

South West Clinical School Journal

No abstract provided.

Exploring The Experiences Of Undergraduate Nursing Students Using E-Workbooks: A Qualitative Study, Jo Boote

South West Clinical School Journal

#400words: reasearch report

An Llm-Based Agentic Network Traffic Incident-Report Approach Towards Explainable-Ai Network Defense, Chia Hong Chou, Arjun Sudheer, Younghee Park

Faculty Research, Scholarly, and Creative Activity

Traditional intrusion detection systems for IoT networks achieve high classification accuracy but lack interpretability and actionable incident-response capabilities, limiting their operational value in security-critical environments. This paper presents a graph-based multi-agent framework that integrates ensemble machine learning with Large Language Model (LLM)-powered incident report generation via Retrieval-Augmented Generation (RAG). The system employs a three-phase architecture: (1) a lightweight Random Forest binary pre-detection, achieving 99.49% accuracy with a 6 MB model size for edge deployment; (2) ensemble classification combining Multi-Layer Perceptron, Random Forest, and XGBoost with soft voting and SHAP-based feature attribution for explainability; and (3) a ReAct-based summary agent that …

Guide To Drought Tolerance Of Utah Field Crops, Matt Yost, Tina Sullivan, Dakota Boren, Luree Johnson, Melanie Mills, Earl Creech, Boyd Kitchen, Randall Violett

All Current Publications

Crop variety selection is one of the most important choices on the farm. Crop genetics determine a significant portion of the yield potential and resource use efficiency. Crop types and genetics that use water more efficiently will become increasingly important as water becomes scarcer. Throughout Utah and the Western United States, water availability is decreasing due to various factors, including reduced snowpack and rapid urban growth. Alfalfa, other hay, small grains, and corn are grown on more acres than any other crops in Utah and much of the Intermountain West. These crops all have varieties, hybrids, and cultivars with the …

Small Grain Forage Production Guide, Matt Yost, Megan Baker, Earl Creech, Justin Wyatt Clawson, Michael Pace, Kalen Taylor, Cory Farnsworth, Jacob Hadfield, Corey Ransom, Steven Price, Claudia Nischwitz, Clara Anderson

All Current Publications

Small grain forages can be used for pasture, hay, and silage and have become more common in cropping systems in Utah and the western United States. The most common small grain species used for forage production are barley, oat, rye, triticale, and wheat. Although there has been an increase in the use of small grains for forage production in the western U.S., little published information is available on best management practices for small grain forage production. This guide will discuss the key production practices for small grains used for forage.

Irrigation, Crop, And Soil Management Impacts On Water Use In Pivots/Laterals, Tejinder Singh, Matt Yost, Masoumeh Hashemi, Burdette Barker, Cheyenne Reid, Rebekah E. Iverson

All Current Publications

In this fact sheet, we describe evapotranspiration (ET), introduce a new tool, the soil moisture evapotranspiration (SMET) model, and share results from multi-year trials across Utah evaluating different center-pivot irrigation technologies, deficit irrigation strategies, crop types, drought-tolerant crop genetics, and conservation agriculture practices. These findings highlight how Utah growers can improve water productivity and maintain profitable production under limited water supplies.

Correction: The Formation Of Tau Pore-Like Structures Is Prevalent And Cell Specific: Possible Implications For The Disease Phenotypes, Cristian A Lasagna-Reeves, Urmi Sengupta, Diana Castillo-Carranza, Julia E Gerson, Marcos Guerrero-Munoz, Juan C Troncoso, George R Jackson, Rakez Kayed

Faculty, Staff and Students Publications

This corrects the article "The formation of tau pore-like structures is prevalent and cell specific: possible implications for the disease phenotypes" in volume 2, 56.

Relative Impact Of Multidomain Lifestyle Interventions On Deficit Accumulation Frailty Over 24 Months In The U.S. Pointer Trial, Mark A Espeland, Kayloni Olson, Christy C Tangney, Darren R Gitelman, Maryjo Cleveland, Amber A Thro, Yitbarek N Demesie, Heather M Snyder, Rachel A Whitmer, Pankaja Desai, Rifat Alam, Lucia Crivelli, Thomas M Holland, Olivia Preissle, Rema Raman, Michele K York, Laura D Baker

Faculty, Staff and Students Publications

Background: Multidomain lifestyle interventions hold promise as approaches to slow aging. Deficit accumulation frailty indices (FIs) are increasingly used to capture aging processes. Frailty is highly associated with increased mortality and chronic disease risk, but the degree to which multidomain lifestyle changes impact frailty is not clear.

Methods: The U.S. Study to Protect Brain Health through Lifestyle Intervention to Reduce Risk (U.S. POINTER) was a 2-year randomized clinical trial to compare two multidomain lifestyle interventions designed to increase exercise, improve diet, and promote social and cognitive stimulating activities and health monitoring. The Structured intervention incorporated greater structure, intensity, and accountability …

Ex Vivo Effect Of Apixaban On Hemostatic Biomarkers In Children With Heart Disease: A Saxophone Trial Substudy, Ghada A Aborkhees, Amy J Barr, Kevin Dietrich, Christoph Male, Zhaoqing Wang, Chen Yao, R Mark Payne, Andrew C Glatz, Paul Monagle, Kristin M Burns, Alison M Reedy, Joshua L Dyme, Peter H Schafer, Antoinette Ajavon-Hartmann, Lesley G Mitchell

2020-Current year OA Pubs

BACKGROUND: The SAXOPHONE (Safety of Apixaban on Pediatric Heart Disease on the Prevention of Embolism) trial demonstrated the safety of apixaban for thromboprophylaxis in children with heart disease. Included a priori in the trial design was an exploratory biomarker substudy to evaluate the effects of apixaban on surrogate biomarkers of efficacy, thrombin generation capacity, and hemostatic proteins. The study assessed changes in d-dimer, thrombin generation assay parameters, factor VIII, fibrinogen, protein C, and protein S in children receiving apixaban compared with standard-of-care vitamin K antagonists (VKAs) or low-molecular-weight heparin.

METHODS: SAXOPHONE participants aged >1 year (n=182) had blood samples for …

Validate-Perianal: An International Real-World Multi-Centre Exploratory Validation Of The Topclass Definition Of A Radiologically Healed Fistula In Perianal Fistulising Crohn's Disease, Easan Anand, Thirza J Van Croonenburg, Sami Samaan, Phil Tozer, Ailsa Hart, Parakkal Deepak, David H Ballard, Jaap Stoker, Phillip Lung

2020-Current year OA Pubs

OBJECTIVES: Radiological healing on MRI is the ultimate therapeutic goal in Class 2a perianal fistulising Crohn's disease (pfCD). The TOpClass consortium recently defined radiological healing (TOpClass-RH) by the absence of T2 hyperintensity, a completely fibrotic fistula tract, and the absence of contrast enhancement when used. This study aimed to validate TOpClass-RH in real-world clinical practice.

MATERIALS AND METHODS: VALIDATE-PERIANAL was a retrospective, multi-centre international study. Patients with pfCD with a baseline MRI scan showing active disease and follow-up MRI evidence of radiological fistula healing between 2021 and 2023 were identified. Paired scans were independently reviewed by three gastrointestinal radiologists using …

Emerging Paradigms In Connectome-Guided Neurosurgery For Central Nervous System Tumors: A Narrative Review Of Structural And Functional Connectomics, Tirath Patel, Hamza Yousuf Ibrahim, Muhammad Abbas, Muzna Amir Ali, Sana Sohrab, Kinza Nawaz, Syeda Ramish Zehra Kazmi, Bhumi Daishik Patel, Nikhilesh Anand

School of Medicine Publications

Connectomics is a comprehensive mapping of structural and functional brain networks. It has introduced a paradigm shift in neurosurgery by redefining brain tumors as network disorders rather than isolated lesions. Unlike traditional surgeries, connectome-guided neurosurgery conceptualizes brain tumors as network disorders and aims to preserve brain function in resection. The objective was to study the role of connectome-guided neurosurgery in the management of Central Nervous System tumors and the use of structural and functional connectomics in tumor resection while preserving neurological function. Articles have been identified by searches of PubMed, Scopus and Google scholar from January 2000 to May 2025, …

Machine Learning In Architecture: A Bibliometric Analysis Approach Of Trends, Influential Authorship, And Research Gaps From 2020 To 2024, Emokpae Erebor, Damilola Adesina, Benjamin Moral, Modi Zango

Architecture and Planning Journal (APJ)

This paper presents the findings of the bibliometric analysis investigating how the current research landscape of machine learning in the discipline of architecture has evolved between 2020 and 2024. This study employs a bibliometric methodology, drawing insights from peer-reviewed journal articles from 2020 to 2024, which were sourced from databases such as Web of Science, Scopus and Science Direct. Keywords were refined using Boolean operators to identify dominant trends, key application areas and ongoing research gaps. The goal of this paper is to provide a structured knowledge base that can guide future research by highlighting emerging directions. This study serves …

Tanggung Jawab Llngkungan Perusahaan, Mas Ahmad Santosa, S.H.

Jurnal Hukum & Pembangunan

Abstract

An Assessment Of Biophilic Design Strategies Application In Selected Hostels In A Typical Tertiary Institution, Nigeria., Emokpae Erebor, Foluke Jegede, Pontip Nimlyat, Benjamin Moral

Architecture and Planning Journal (APJ)

Designing spaces that incorporate the principles of biophilic design enhances the buildings occupants closeness to nature while also enhancing spaces connectivity and place conditions. It has environmental, health and other important benefits not only for the environment but also for the human beings that domicile around them. Firstly, this study was carried out using quantitative data obtained from 120 female students of two selected hostel facilities in a typical private University in South-West Nigeria. Secondly, observation is in identifying the actual applications where these strategies have been applied within these hostels through photographic images. This was done by identifying different …

The Effect Of Livelihood Capital Accessibility On The Financial Security And Financial Well-Being Of Sheep Farming Households (Survey In Wanaraja Subdistrict, Garut Regency), Suhendarsyah Suhendarsyah, Unang Yunasaf, Sondi Kuswaryan

Jurnal Ilmu Ternak Universitas Padjadjaran

This study analyzed the influence of livelihood capital accessibility on the financial security and financial well-being of sheep-farming households in Wanaraja Subdistrict, Garut Regency. A quantitative approach was used through a survey with organized interviews of 95 sheep farmers. The research variables include livelihood capital accessibility (X), financial security (Z), and financial well-being (Y). The livelihood capital accessibility construct was built as a Higher-Order Construct with five dimensions: human, natural, financial and physical capital. Data analysis used Partial Least Square Structural Equation Modeling (PLS_SEM) with a two-stage approach. The results evince that social capital are the most influential dimensions in …

Reproductive Performance Of Friesian Holstein Crossbred Dairy Cattle After A Foot-And-Mouth Disease Outbreak In Lembang, Indonesia, Hanunghanindito Pamungkas, Septiyani Septiyani, Nurcholidah Solihati

Jurnal Ilmu Ternak Universitas Padjadjaran

Foot-and-mouth disease (FMD) is a highly contagious viral disease that may impair reproductive efficiency in dairy cattle. This study aimed to evaluate changes in the reproductive performance of Friesian Holstein crossbred dairy cows following an FMD outbreak at UPTD BPTSP and HPT Cikole, Lembang, West Java, Indonesia. A retrospective study was conducted using reproductive records collected from 2019 to 2023. The reproductive parameters analyzed were calving interval, service per conception, conception rate, service period, and first mating postpartum. Differences between the pre- and post-FMD periods were assessed using paired sample t-tests. The results showed significant differences in calving interval, service …

Polymorphism Of The Mx Gene In Riau Kampung Chickens, Elfawati Elfawati, Restu Misrianti, Sadarman Sadarman

Jurnal Ilmu Ternak Universitas Padjadjaran

One of the genetic markers for avian influenza is the Mx gene. The purposed of this study was to determine the polymorphism of the Mx gene of kampung chicken in Riau Province. A total of 61 samples from three subpopulations have been genotyped using PCR-RFLP. Allele and genotype frequencies have been calculated using PopGene. The Mx gene was amplified, producing a DNA fragment measuring 299 base pairs. This fragment was digested with the Hpy81 enzyme, which yielded three genotypes: the AA genotype showed by a single 299 bp band; AG showed by 299, 200, and 99 bp bands; and GG …

The Potency Of Inulin Extraction Waste Fermentation From Local Tubers As A Feed Additive, Mohamad Septian, Danes Suhendra, Mikael Sihite, Dyah Saputri

Jurnal Ilmu Ternak Universitas Padjadjaran

This study aims to determine the potential of inulin extraction waste fermentation as a feed additive based on the content of lactic acid, dry matter, pH, and Fleigh points. This research was conducted from March to June 2022 at the Animal Husbandry and Fisheries Laboratory, Tidar University. The experimental design used in this study was a Completely Randomized Design with 4 treatments (fermentation of inulin extraction waste: T1 Dioscorea alata (uwi), T2: ganyong (Dioscorea alata discolor), T3: gadung(Dioscorea hispida), and T4: umbi ungu (Ipomoea batatas). Each treatment was replicated 5 times. The variables …

Replacing Field Grass By Cassava Leaf Silage Added With Kefir On Productivity Of Lactating Dairy Cow, Azhar Amir, Afton Atabany, Ade Mubarak, Hilda Susanty

Jurnal Ilmu Ternak Universitas Padjadjaran

This study aimed to analyze the effect of cassava leaf silage (CLS) with added kefir on the productivity of lactating dairy cows when replacing field grass. Four Holstein Friesian cows in the early lactation phase (66 ± 11 days in lactation) in the second lactation cycle were randomly divided into four dietary treatments based on a 4×4 Latin square design. Diet treatments consisted of control (50% field grass + 25% concentrate + 25% tofu dregs); CLS 0 Kf (30% field grass + 20% CLS with no added kefir + 25% concentrate + 25% tofu dregs); CLS 2.5 Kf (30% field …

Community Perception Of Wild Boar Meat Consumption Based On A Halal Perspective, Roudhotul Jannah, Hamzah Siswara, Yuny Erwanto, Meireni Cahyowati

Jurnal Ilmu Ternak Universitas Padjadjaran

Consuming wild boar meat is still popular among the people of Sekaran Village, Tuban Regency, even though the religion they believe in is Islam. The aim of this research is to investigate people's perceptions of the consumption of wild boar meat, to know the background of people who consume wild boar meat and to know the distribution of wild boar meat in the Tuban area. This research was carried out in several stages, namely observation, interviews using a sample of 100 respondents and documentation. Perception measurement uses a likert scale with an assessment score of 1-3 scores and data processing …

The Potential Of Bioactive Peptides From Goat Milk Kefir With Antibacterial Activity As An Antibiotic Substitute, Dhea Athillah, Jajang Gumilar, Eka Wulandari

Jurnal Ilmu Ternak Universitas Padjadjaran

This study aims to determine the optimal incubation time for goat milk kefir that produces the highest antibacterial peptides, and to determine the antibacterial activity of purified goat milk kefir. Protein levels were determined using the microassay method. Kefir, which is known to have the best incubation time for producing the highest antibacterial activity when ultrafiltered with a 10 kDa cut-off membrane, was analyzed for its molecular weight using SDS-PAGE. The antibacterial activity was tested against pathogenic bacteria E. coli and S. aureus. The highest soluble protein content was found in kefir incubated for 36 hours, with a soluble …

Effect Comparison Of Moringa Oleifera L. Extract Supplementation To Cauda Epididymis Plasma Diluent On Simmental Semen, Arsya Aldinsyah, Nur Ducha, Dhanis Fitriana

Jurnal Ilmu Ternak Universitas Padjadjaran

The success of Artificial Insemination (AI) programs in cattle largely depends on the quality of semen after freezing. This study aimed to evaluate the effect of supplementing cauda epididymis plasma (CEP) diluent by Moringa oleifera seed extract (MSE) on the post-thaw quality of Simmental bull semen. Semen samples were collected by bulls by individual motility ≥70% and processed at the Singosari Artificial Insemination Center between October and December 2024. The study employed a Completely Randomized Design (CRD) by four MSE concentrations: 0, 1, 5, and 10 mg/mL of MSE. each tested replicated in six for motility, viability, and membrane integrity. …

Improving Anesthetic Management Of Pheochromocytoma: ​ ​An Educational Initiative Led By Student Registered Nurse Anesthetists​, Kerryn Nicholls

Scholars Week

Anesthetic management of pheochromocytoma presents challenges to experienced nurse anesthetists and recent graduates alike due to the rarity and complex pathophysiology. The purpose of this DNP project was to provide information and education informed by an extensive literature review regarding the anesthetic management of pheochromocytoma for the benefit of future nurse anesthesia practice. The project was accomplished through an educational presentation and novel clinical care flow chart focused on perioperative anesthetic care of pheochromocytoma excision to an audience of practicing certified registered anesthetists (CRNA’s) in two rural Kentucky hospitals. The findings of this project demonstrated that student nurse anesthesia students …

Improving Anesthesia Provider Confidence In The Identification, Management, And Treatment Of Postoperative Delirium, Brittany M. Whistle, Charles Dustin Phelps

Scholars Week

Purpose: Postoperative Delirium (POD) is a potentially devastating complication of anesthesia that is poorly understood by clinical staff leading to poor outcomes for surgical patients. This study is meant to determine if a focused knowledge presentation accompanied by visual aids could increase anesthesia providers confidence in identifying, diagnosing, and treating Postoperative Delirium.

Methodology: Utilizing a statistical model to analyze respondents results on a standardized test administered before and after an informational presentation with visual aids on the topic of Postoperative Delirium.

Results: Results indicated a statistically significant difference between pretest and posttest scores, with a p-value of .002, t(11) = …

Exploring The Impact Of A Multifaceted Standardized Wellness Program On Physical, Mental, Emotional, And Spiritual Health In Nurse Anesthesia Students, Lauren Kulaszewski, Amber Hurt

Scholars Week

Abstract

Purpose

Nurse anesthesia students experience substantial academic and clinical stress, placing them at increased risk for anxiety, depression, burnout, and suicidal ideation. Despite this risk, there is limited guidance on the effectiveness of standardized, programmatic wellness initiatives in nurse anesthesia education. The purpose of this project was to evaluate whether implementation of a standardized wellness program, compared with reliance on independent student-initiated practices, could improve mental, physical, emotional, and spiritual well-being among second- and third-year nurse anesthesia students.

Methodology

A pre–post intervention design was used over a six-month period at a large academic institution. Second- and third-year nurse anesthesia …

Assessing The Impact Of Interprofessional Simulation Training On Perioperative Staff's Confidence In Managing Maternal Hemorrhage, Mallory Duncan, Lidia Vazquez

Scholars Week

Globally, maternal mortality rates remain a critical public health challenge, often related to inadequate healthcare infrastructure in low-income countries. Yet according to the American Journal of Obstetrics and Gynecology (ACOG), maternal mortality rates in the United States are also on the rise, with nearly 32.9 deaths per 100,000 live births. These deaths are largely contributed to maternal hemorrhage (PPH), defined by ACOG as cumulative blood loss of at least 1,000 mL accompanied by symptoms of hypovolemia within 24 hours of the birth process. These findings underscore an urgent need to strengthen the training for perioperative staff in the management of …

Occupational Sevoflurane Exposure And Awareness Of Health Effects Among Anesthesia Providers, Hayden Fell

Scholars Week

Key words:

Sevoflurane exposure Occupational safety CRNAs Anesthetic gas exposure Workplace hazard

The anesthetic gas sevoflurane is of unique interest amongst anesthesia providers as a potential workplace hazard. This project aimed to evaluate CRNA knowledge, clinical practices, symptoms, and perceptions related to occupational sevoflurane exposure amongst Certified Registered Nurse Anesthetists (CRNAs) at a regional hospital in Kentucky.

This quality improvement project used a pre- and post-intervention survey design. Ten CRNAs participated in the project. A pre-survey was given, followed by an educational session informing participants of guidelines regarding Sevoflurane exposure and literature findings of Sevoflurane as a potential workplace …

Local-Nonlocal Dispersal, Behavioral Responses, And Intervention Strategies In Infectious Disease And Addiction Dynamics, Ghilmana Sarmad

Thesis/ Dissertation Defenses

This dissertation explores how epidemiological and behavioral processes interact across spatial and temporal scales to shape the dynamics of infectious diseases and addiction. Bringing together mathematical rigor and biological realism, it develops and analyzes a series of nonlinear models that capture the effects of spatial heterogeneity, mobility patterns, behavioral adaptation, and intervention strategies. Using tools from semigroup theory, functional analysis, stability analysis, and numerical simulation, the study provides a unified framework for understanding how awareness programs, fear-driven protection, vaccination, and social reinforcement influence transmission thresholds, persistence, and long-term population outcomes.

awareness-based interventions, where a basic reproduction number is derived and …