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Articles 23731 - 23760 of 1791792
Full-Text Articles in Entire DC Network
University Honors 2025-26 Hall Of Fame, Who's Who Inductees, Staff Report
University Honors 2025-26 Hall Of Fame, Who's Who Inductees, Staff Report
University of Mississippi News
OXFORD, Miss. – The University of Mississippi has announced inductees into the 2025-26 Hall of Fame.
A Scoping Review Of The Objective Structured Assessment Of Technical Surgical Skills (Osats), David J. O'Regan, Christopher Caddy, Retnagowri Rajandram, Paul Barach
A Scoping Review Of The Objective Structured Assessment Of Technical Surgical Skills (Osats), David J. O'Regan, Christopher Caddy, Retnagowri Rajandram, Paul Barach
College of Population Health Faculty Papers
BACKGROUND: Objective structured assessment of technical skills (OSATS) offers an objective tool for assessing bowel anastomosis on a benchtop. It was developed in 1997 to set appropriate standards and expectations for the surgical trainee. OSATS have become the gold standard of assessment across many disciplines. A global Likert rating scale, including respect for tissues, instrument handling, economy of movement, and flow of the operation predominates the literature. This has led to many questioning OSATS objectivity, claiming the process to be time-consuming, subjective, demanding human resources, and requiring extensive training of the trainer. We believe OSATS scoring has omitted the 22-point …
Perioperative Outcomes And Challenges In Cytoreductive Surgery With Hyperthermic Intraperitoneal Chemotherapy: A Single-Institution Case Series, Parli Raghavan Ravi, Maha Abdullah Naseer Alshaibi, Raj Sahajanandan, Mohammed Abdullah Saif Alhosni, Srinivas Shyam Mantha
Perioperative Outcomes And Challenges In Cytoreductive Surgery With Hyperthermic Intraperitoneal Chemotherapy: A Single-Institution Case Series, Parli Raghavan Ravi, Maha Abdullah Naseer Alshaibi, Raj Sahajanandan, Mohammed Abdullah Saif Alhosni, Srinivas Shyam Mantha
Sultan Qaboos University Medical Journal
Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is a high-risk, but potentially curative, treatment for peritoneal surface malignancies. This retrospective analysis was conducted between March 2023 and September 2025 at Sultan Qaboos Comprehensive Cancer Care and Research Centre, Muscat, Oman, with the objective of analysing perioperative outcomes and challenges in patients undergoing CRS with HIPEC. Data on demographics, intraoperative variables and postoperative outcomes were collected and statistically analysed. A total of 25 consecutive patients were included. The cohort had significant comorbidities (American Society of Anesthesiologists II/III = 84%). Significant metabolic stress was evidenced by increased lactate (P <0.001) and base deficit (P …0.001)>
Growing Healthy Habits: Impacts Of A Youth Community Garden For Children In Rural Mississippi, Olivia G. Degravelle
Growing Healthy Habits: Impacts Of A Youth Community Garden For Children In Rural Mississippi, Olivia G. Degravelle
Honors Theses
This study examines the implementation and outcomes of a Youth Garden Program conducted in Pontotoc, Mississippi. Funded by the Allstate Community Service Project Grant, the Youth Garden was constructed within the previously established Pontotoc Community Garden. The initiative comprised four weekly workshops designed for participants ranging from preschool to adolescence. Each session incorporated hands-on fruit and vegetable (FV) planting or harvesting, an educational lesson, and a complementary craft activity. Children’s FV consumption patterns, nutritional knowledge, and attitudes toward FV were assessed through pre- and post-program surveys. In addition, the photo-elicitation interview method invited participants to take digital photographs of garden …
Good Resource, Bad Vibe: How Well Does The Media Reflect Economic Activity?, Brett Watson, Noah Burke, Dayna Jean Defeo
Good Resource, Bad Vibe: How Well Does The Media Reflect Economic Activity?, Brett Watson, Noah Burke, Dayna Jean Defeo
ISER Reports
Resource industries like oil and fishing are characterized by boom-and-bust cycles – there are “good years” and “bad years.” In communities that are highly connected to a particular resource, these economic shocks are foregrounded in the public attention. This paper compares economic indicators with media coverage over a 10-year period in Homer, Alaska. Specifically, it explores the economic shock of the 1989 Exxon Valdez oil spill and looks at how media coverage aligned to the fishery performance during the recovery years. Even as the fishery recovered to pre-spill performance in dollars, the media sentiment did not “bounce back” as quickly. …
Master Of Social Work Faculties Integration Of Gender And Sexuality Diverse Content: A Cross-Sectional, Quantitative Study, Lynn Mazur
Social Work Doctoral Dissertations
Master of social work (MSW) students may be entering into field practice without meeting the necessary competencies for practice to address the needs of the gender and sexuality diverse (GSD) population. The literature supports that GSD content may be absent from course content. This cross-sectional design study aimed to understand what factors influence MSW faculty to incorporate GSD content into their coursework. MSW faculty at Council on Social Work Education (CSWE, 2022) accredited programs were invited via email to complete an online, anonymous, and voluntary survey. The results suggested strong support for the integration of GSD content into the coursework, …
Inclusive Special Education: Changing Mindsets And Practices To Improve Student Achievement, Nicole S. Pechous
Inclusive Special Education: Changing Mindsets And Practices To Improve Student Achievement, Nicole S. Pechous
Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–
Decades after federal mandates for special education services, students with disabilities (SWD) continue to lag significantly behind their peers in academic achievement and post–school outcomes. This quantitative study explores how the inclusive mindsets and collaborative practices of general and special education teachers from a medium–sized, suburban Midwestern district improved after participating in a year-long training series on inclusive practices. The study also explores the impact of increased inclusive mindsets and practices on student reading achievement, particularly for students with disabilities. Using a quantitative design, changes in inclusive mindsets and practices for participating teachers were analyzed. Findings indicated that participation in …
The Influence Of The Timing Of Definitive Restoration Placement After Root Canal Completion: A 22-Year Retrospective Study, Shikha Gupta
The Influence Of The Timing Of Definitive Restoration Placement After Root Canal Completion: A 22-Year Retrospective Study, Shikha Gupta
Master's Theses (2009 -)
Objective: To evaluate how the time interval between root canal obturation and the placement of a definitive restoration impacts the incidence of tooth failure, defined as non-surgical retreatment, apical surgery, or extraction. Methods: This 22-year-retrospective cohort study utilized electronic health records from the Marquette University School of Dentistry (MUSoD) axiUm database, analyzing 11,002 teeth treated between 2004 and 2026. Inclusion criteria required patients to be at least 18 years of age, categorized as established patients of record, with all non-surgical root canal treatments (NSRCT) meeting the 2020 AAE quality standards. The interval between obturation and restoration was categorized into seven …
Cybersecurity Integration In Research Stage Connected Devices Within Healthcare Environments, Klemens Koszarek
Cybersecurity Integration In Research Stage Connected Devices Within Healthcare Environments, Klemens Koszarek
Master's Theses (2009 -)
The rapid growth of connected devices in healthcare environments has significantly expanded the cybersecurity threat landscape, extending the potential risks beyond traditional hospital networks. Regulatory guidance from the FDA and risk management frameworks such as the NIST Cybersecurity Framework (NIST CSF) provide an approach for managing cybersecurity risk in connected systems. However, these principles are not always applied during early stages of device development. As a result, security consideration may be deferred until later stages of development, allowing for vulnerabilities to persist in systems as they move toward clinical or commercial deployment. This study presents a structured method for integrating …
Emotional Awareness And Resilience In Adolescents, Emilie Zimmerman
Emotional Awareness And Resilience In Adolescents, Emilie Zimmerman
Master's Theses (2009 -)
Adolescent trauma exposure is prevalent and associated with a range of negative developmental outcomes. However, some youth demonstrate resilience. Emotional awareness, a foundational component of emotion regulation, may play a role in promoting adaptive functioning following adversity, though its contribution to resilience in trauma-exposed adolescents remains unclear. The present study examined whether emotional awareness is associated with multiple domains of resilience including prosocial behavior, self-efficacy to handle conflict, perceived resilience, and emotional and conduct problems, after accounting for trauma exposure. Participants were 36 adolescents enrolled in a support program for at-risk youth. Data were obtained from youth-report measures of trauma …
Family Processes As A Protective Factor Between Adverse Childhood Experiences And Adolescent Delinquency, Tessa Johnson
Family Processes As A Protective Factor Between Adverse Childhood Experiences And Adolescent Delinquency, Tessa Johnson
Theses and Dissertations
This study explores whether family processes (i.e., parental attachment and parental discipline/monitoring) serve as protective factors between the relationship of adverse childhood experiences (ACEs) and adolescent delinquency. Prior research has established an association between ACEs and many negative life outcomes, including delinquent behavior, while strong parental attachment and parental discipline/monitoring are linked to lower rates of delinquency. However, the interplay of these three factors has been understudied. Drawing on data from the 2024 Florida Youth Substance Abuse Survey (FYSAS) (N=22,016), this study examines the relationship between ACEs, family processes, and delinquency using negative binomial regression models. Results indicate that parental …
Rioi: A Microwave-Photonic Rf-Interferometric Interrogation Technique For Enhanced Fiber Optic Sensing, Chen Zhu, Ruimin Jie, Chenxi Huang, Jie Huang
Rioi: A Microwave-Photonic Rf-Interferometric Interrogation Technique For Enhanced Fiber Optic Sensing, Chen Zhu, Ruimin Jie, Chenxi Huang, Jie Huang
Electrical and Computer Engineering Faculty Research & Creative Works
Fiber optic interferometric (FOI) sensors are widely recognized for their high sensitivity, design flexibility, and multiplexing capabilities, making them ideal for applications ranging from structural health monitoring to biomedical diagnostics. However, conventional optical-domain interrogation techniques are often limited by the performance constraints of spectrometers. In this work, we present a radiofrequency (RF)-interferometric optical interrogation (RIOI) method for FOI sensors. This approach leverages microwave photonic (MWP) processing to encode the optical interference phase into an RF signal, which is then combined with a reference RF signal to produce a microwave-domain interferogram. By tracking spectral shifts in the RF domain, RIOI achieves …
Working At The Margins In Interwar Yugoslavia, Stefano Petrungaro
Working At The Margins In Interwar Yugoslavia, Stefano Petrungaro
Central European Studies
Prostitutes, beggars, folk healers, peddlers, wandering artists, and bear-leaders: Working at the Margins in Interwar Yugoslavia shows how work shaped their relations with the state and the rest of their world. The protagonists of the book’s story lived on the fringes of society and engaged in activities that were only partially recognized, from a legal and social point of view, as proper jobs, while some of them had no job at all. This book looks at Yugoslavia’s disciplining and social engineering practices through the lens of socially marginal workers. The analysis shows that in this period the South Slav regions …
Research And Innovation Update, April 15, 2026, Office Of The Vice President For Research And Innovation
Research And Innovation Update, April 15, 2026, Office Of The Vice President For Research And Innovation
Office of Research, Economic Engagement and Outreach
No abstract provided.
Lateral Minimally Invasive Si Joint Fusion Following Adult Spinal Deformity: A Case-Report And Literature Review, Basel Musmar, Hassan Saad, Joshua Pelta-Heller
Lateral Minimally Invasive Si Joint Fusion Following Adult Spinal Deformity: A Case-Report And Literature Review, Basel Musmar, Hassan Saad, Joshua Pelta-Heller
Department of Neurosurgery Faculty Papers
This case report describes lateral minimally invasive sacroiliac (SI) joint fusion for SI joint–mediated pain in a patient with a history of adult spinal deformity surgery. A 48-year-old woman with multiple medical comorbidities previously underwent long thoracolumbar fusion. She subsequently had L4-S1 anterior lumbar interbody fusion and posterior L4-pelvis instrumentation in 2010. Following a ground-level fall in 05/2021, she developed new left-sided hip and sacroiliac pain with intermittent left lower-extremity numbness. Radiographs demonstrated mild hip osteoarthritis and sacroiliac joint sclerosis; spine imaging revealed discontinuity of the right iliac fixation rod without acute fracture. MRI of the hip showed bilateral sacroiliitis …
Beyond The Stacks: Borrowing Of Immersive Technologies And Smart Eco Systems To Reimagine Libraries., Vuppala Lingaiah
Beyond The Stacks: Borrowing Of Immersive Technologies And Smart Eco Systems To Reimagine Libraries., Vuppala Lingaiah
Library Philosophy and Practice (e-journal)
This theoretical Chapter explores the paradigm shift of knowledge access, user experience, and institutional viability through the integration of immersive technologies, such as augmented reality (AR), virtual reality (VR), mixed reality (MR), artificial intelligence (AI), and the Internet of Things (IoT), within the new paradigm of funky libraries, and how these technologies are changing knowledge access, user experiences, and the institutional sustainability of various library environments. Methodology: The research approach is non-empirical and exploratory-conceptual, based on a synthesis of systematic literature, thematic clustering of the existing literature, and theoretical critique of recent peer-reviewed findings. The chapter is based on more …
Beyond The Evidence: The Cervical Collar As Cultural Artefact, Tim Nutbeam
Beyond The Evidence: The Cervical Collar As Cultural Artefact, Tim Nutbeam
Peninsula Medical School
Background: Cervical collar application remains prevalent in trauma care despite the absence of evidence of neurological benefit from spinal immobilisation. Clinical behaviour in this area has proven resistant to change, and the persistence of the collar requires explanation beyond the evidential debate alone. The fear of cervical injury has origins that predate clinical practice. Neurobiological preparedness theory suggests that threat associations linked to survival-relevant stimuli are more rapidly acquired and more durably maintained than other learned fears; the cervical region is a plausible candidate for this form of prepared response. This disposition has been reinforced by centuries of cultural practice: …
Ellagic Acid Reduces Inulin's Adverse Effects: A Combined Approach To Enhance Therapeutic Potential In Nonalcoholic Steatohepatitis, Tharani Senavirathna, Shafaei, Ricky Lareu, Lois Balmer
Ellagic Acid Reduces Inulin's Adverse Effects: A Combined Approach To Enhance Therapeutic Potential In Nonalcoholic Steatohepatitis, Tharani Senavirathna, Shafaei, Ricky Lareu, Lois Balmer
Research outputs 2022 to 2026
This mouse study investigates the efficacy of ellagic acid (EA), a potent antioxidant in fruits and nuts, and inulin, a prebiotic known for gut microbiota benefits, in nonalcoholic steatohepatitis (NASH). A Western-style diet (WD) was used to induce NASH in C57BL/6J male mice for 16 weeks. Mice then received EA (100 mg/kg/day, oral gavage, 5 days/week) and/or 5% inulin (w/w in diet) for 12 weeks while continuing WD. Inulin increased energy intake and trended toward higher body weight and fasting glucose. EA reduced liver weights and restored the liver-to-body weight ratio. EA and inulin combined significantly reduced steatosis and hepatocyte …
Parental (Dis)Satisfaction With School Placement To Achieve Inclusion: A Cross-Country Comparison, Veslemøy Maria Fossum Johansson, Suanne Gibson, Stuart Woodcock, Anders Dechsling, Harry Kullmann, Marte Karoline Herrebrøden, Line Britt Ulriksen, Anders Nordahl-Hansen
Parental (Dis)Satisfaction With School Placement To Achieve Inclusion: A Cross-Country Comparison, Veslemøy Maria Fossum Johansson, Suanne Gibson, Stuart Woodcock, Anders Dechsling, Harry Kullmann, Marte Karoline Herrebrøden, Line Britt Ulriksen, Anders Nordahl-Hansen
Research outputs 2022 to 2026
Background – This study draws on data from a larger international project exploring parents' perceptions of the education of their children with special educational needs and/or disabilities (SEND). Using responses from 1, 309 parents in Australia, England, Germany, and Norway it examines parental satisfaction with mainstream and special schools, and parents' school placement preferences, including willingness to change schools. Parental satisfaction is assessed as an overall evaluation of how well the child's school placement meets their needs, without distinguishing between specific aspects of the school experience. The study also explores whether the child's level of support is associated with these …
Horseshoe Kidneys In Transplantation: Underutilization Despite Comparable Quality And Favorable Outcomes: Unos Registry Analysis (2007-2023), Abigail W. Cheng, Samrawi Misiker, Roberto Sagaribay, Kavita Batra
Horseshoe Kidneys In Transplantation: Underutilization Despite Comparable Quality And Favorable Outcomes: Unos Registry Analysis (2007-2023), Abigail W. Cheng, Samrawi Misiker, Roberto Sagaribay, Kavita Batra
School of Medicine Research Poster Showcase
Introduction: Horseshoe kidneys (HSKs) are the most common renal fusion anomaly, occurring in approximately 1 in 500 individuals and often discovered incidentally. Historically excluded from transplantation due to complex anatomy, advances in surgical techniques have made HSK transplantation increasingly feasible. Although successful procurement and transplantation have been described in case reports, national-level data comparing donor characteristics and organ utilization between HSK and non-HSK donors remain limited. This study characterizes donor demographics, clinical profiles, and organ utilization of HSK donors using the United Network for Organ Sharing (UNOS) database.
Methods: A retrospective analysis of the UNOS kidney transplant registry was performed, …
Building On Common Ground: Autistic Adults' And Parents Of Young Autistic Children's Perspectives Of Early Behavioral Intervention Practices, Sophia R. D'Agostino, Naima Bhana-Lopez, Trenton J. Landon, Alyssa Roylance, Avery Briggs
Building On Common Ground: Autistic Adults' And Parents Of Young Autistic Children's Perspectives Of Early Behavioral Intervention Practices, Sophia R. D'Agostino, Naima Bhana-Lopez, Trenton J. Landon, Alyssa Roylance, Avery Briggs
Special Education and Rehabilitation Counseling Faculty Publications
The purpose of this study was to examine the perspectives of autistic adults and parents of autistic children regarding applied behavior analysis (ABA)-based early intervention, their beliefs about best practices in early intervention, and their recommendations for improving service delivery. A mixed-methods design was used to compare quantitative survey data from 70 participants (33 autistic adults, 37 parents) with qualitative interview responses (12 autistic adults, 12 parents), exploring perceptions of ABA and early intervention implementation. Quantitative analyses revealed significant group differences in perceptions of ABA’s benefits and side effects: parents rated ABA-based interventions more positively overall, whereas autistic adults expressed …
Hidinet-T: A Transformer Modeling For High-Dimensional Survival Analysis, Aashish Dhanani
Hidinet-T: A Transformer Modeling For High-Dimensional Survival Analysis, Aashish Dhanani
Computer Science Honors Theses
No abstract provided.
Anesthetic Management In Patients With Impella Devices: A Retrospective Review And Clinical Guide, Harrison Yang, Divakara Gouda, Kent B. Berg, Katherine Green, Suvan Sundaresh, Basavana Goudra
Anesthetic Management In Patients With Impella Devices: A Retrospective Review And Clinical Guide, Harrison Yang, Divakara Gouda, Kent B. Berg, Katherine Green, Suvan Sundaresh, Basavana Goudra
Department of Anesthesiology Faculty Papers
Background: The Impella family of percutaneous a left ventricular assist devices are increasingly used for hemodynamic support in patients with cardiogenic shock or advanced heart failure. However, guidance on anesthetic management for patients with Impella support undergoing noncardiac procedures remains sparse. This study reviews perioperative practices and outcomes to inform clinical management.
Methods: Following institutional review board approval, a retrospective analysis was performed of adult patients receiving an Impella device (2.5, CP, 5.0, or 5.5) at Thomas Jefferson University Hospital, Philadelphia, USA, between December 2017 and October 2024. Patients, who subsequently underwent procedures involving anesthesia care were included. Demographics, procedure …
Structure-Property Relationships In Chalcones With Extended Π-Conjugation: Ict Perturbation And Far-Red Fluorescence, Yi Pang, Christopher J. Ziegler, Wei-Yuan Chen, Paityn Houglan
Structure-Property Relationships In Chalcones With Extended Π-Conjugation: Ict Perturbation And Far-Red Fluorescence, Yi Pang, Christopher J. Ziegler, Wei-Yuan Chen, Paityn Houglan
University Research
4-Dimethylamino-2′-hydroxychalcone (DHC) derivatives are known to exhibit distinctive photophysical properties for various applications, including highly fluorescent crystals and molecular imaging. In a continuous effort to establish the structure–property correlation of this class of materials, a series of methoxy-substituted chalcone derivatives with extended π-conjugation have been synthesized to understand the effect of methoxy substituents on the intramolecular charge transfer (ICT) along the backbone. These derivatives displayed low fluorescence in protic solvents (e.g. ϕfl ≈ 0.003–0.009 in H2O), but high fluorescence in a polar aprotic solvent (ϕfl ≈ 0.2–0.35 in DMSO), with emission maxima up to 658 nm. Fluorescence lifetime measurements revealed …
Building A Coordinated Care Network For New Mexico Veterans: A Roadmap For Statewide Implementation, Nosa Akol, Zachary M. Bridgewater, Vincent R. Delsignore, Emily Graham, Mary Rachel Keville
Building A Coordinated Care Network For New Mexico Veterans: A Roadmap For Statewide Implementation, Nosa Akol, Zachary M. Bridgewater, Vincent R. Delsignore, Emily Graham, Mary Rachel Keville
Institute for Veterans and Military Families
With the support of the New Mexico State Legislature, the D’Aniello Institute for Veterans and Military Families (IVMF) is leading a multi-phase project to design a coordinated care system for New Mexican service members, veterans, and their families. In the project’s first phase, the IVMF conducted a landscape assessment to understand the needs of the military-connected community and examined the viability of a coordinated care system for the state. We found that veteran-serving organizations that participated felt that a coordinated care network would be of value to New Mexico veterans, but questions on how best to implement such a network …
Saltfish And Seedcake: Examining Fantasy Through Food Studies, Isabella Martins-Simonsen
Saltfish And Seedcake: Examining Fantasy Through Food Studies, Isabella Martins-Simonsen
Electronic Theses and Dissertations
Although mundane and often overlooked in reality, in fantasy, food, like all other things, is entirely symbolic. Therefore, considering food closely when analyzing a fantasy text offers unique insights into the world being developed, the characters within that world, and the author’s own understanding of both the real and “secondary” world. In this paper, I consider the foods of Earthsea, Narnia, and Middle Earth to offer various perspectives on the worldbuilding and examine the implications of different foods in these well-known settings. For example, the tea served in Narnia creates a fantasy world that is more normal than the strange …
Sex-Specific Autosomal Susceptibility Loci In Systemic Sclerosis: A Genome-Wide Association Study, Inmaculada Rodriguez-Martin, Martin Kerick, Carlos Rangel-Peláez, Carlos Rosa-Baez, Gonzalo Borrego-Yaniz, Lourdes Ortiz-Fernández, Alfredo Guillen-Del-Castillo, Carmen P Simeón-Aznar, José Luis Callejas, Oliver Distler, Susanna M Proudman, Mandana Nikpour, Nicolas Hunzelmann, Jeska K De Vries-Bouwstra, Ariane L Herrick, Yannick Allanore, Marta E Alarcón-Riquelme, Lorenzo Beretta, Shervin Assassi, Christopher P Denton, Maureen D Mayes, Javier Martin, Marialbert Acosta-Herrera
Sex-Specific Autosomal Susceptibility Loci In Systemic Sclerosis: A Genome-Wide Association Study, Inmaculada Rodriguez-Martin, Martin Kerick, Carlos Rangel-Peláez, Carlos Rosa-Baez, Gonzalo Borrego-Yaniz, Lourdes Ortiz-Fernández, Alfredo Guillen-Del-Castillo, Carmen P Simeón-Aznar, José Luis Callejas, Oliver Distler, Susanna M Proudman, Mandana Nikpour, Nicolas Hunzelmann, Jeska K De Vries-Bouwstra, Ariane L Herrick, Yannick Allanore, Marta E Alarcón-Riquelme, Lorenzo Beretta, Shervin Assassi, Christopher P Denton, Maureen D Mayes, Javier Martin, Marialbert Acosta-Herrera
Faculty, Staff and Student Publications
Background: Systemic sclerosis is an immune-mediated inflammatory disease with marked sex differences in prevalence and severity. Although genome-wide association studies (GWAS) have advanced the understanding of systemic sclerosis genetics, sex-aware approaches remain scarce. We aimed to address this gap by examining autosomal sex-specific genetic factors in systemic sclerosis.
Methods: Based on a chromosomal definition of sex, we conducted a sex-stratified autosomal meta-analysis of GWAS in systemic sclerosis. We retrieved patient-level and control data from a previous GWAS for systemic sclerosis and newly recruited participants from an international multicentre collaboration (data cutoff June 1, 2024). Adult patients (aged ≥18 years) were …
Ftsz Forms Biomolecular Condensates In A Polar-Growing Alphaproteobacterium, Todd A Cameron, Miguel Ángel Robles-Ramos, Lorenzo Suigo, Silvia Zorrilla, William Margolin
Ftsz Forms Biomolecular Condensates In A Polar-Growing Alphaproteobacterium, Todd A Cameron, Miguel Ángel Robles-Ramos, Lorenzo Suigo, Silvia Zorrilla, William Margolin
Faculty, Staff and Student Publications
The conserved tubulin homolog FtsZ assembles into GTP-dependent protofilaments that organize the bacterial cell division machinery. Purified Escherichia coli FtsZ (FtsZEc) can form biomolecular condensates in the absence of GTP in macromolecular crowding conditions, but FtsZ condensates have not yet been confirmed in vivo. FtsZ from the Alphaproteobacterium Agrobacterium tumefaciens (FtsZAt) localizes to distinct polar foci during growth and contains an intrinsically disordered region much longer than FtsZEc, suggesting a greater tendency to form condensates. Here, we show that purified FtsZAt readily formed dynamic condensates in vitro under molecular crowding conditions, and the addition of GTP induced the formation …
Single-Nucleus Brain Transcriptomics Reveals Microglia Dysfunction In Multiple System Atrophy, Rasmus Rydbirk, Frederik Nørby Friis Sørensen, Jonas Folke, Henriette Haukedal, Andrea Asenjo Martinez, Irene Lisa Vargas, Simone Mcgarry, Oline Chantell Hollmann, Camila Gherardelli, Sofia Sepulveda, Adam T Szafran, Michael A Mancini, Sanne Simone Kaalund, Tomasz Brudek, Lisette Salvesen, Sara Bech, Justyna Okarmus, Peter Kharchenko, Morten Meyer, Claudio Soto, Kristine Freude, Abhisek Mukherjee, Susana Aznar, Konstantin Khodosevich
Single-Nucleus Brain Transcriptomics Reveals Microglia Dysfunction In Multiple System Atrophy, Rasmus Rydbirk, Frederik Nørby Friis Sørensen, Jonas Folke, Henriette Haukedal, Andrea Asenjo Martinez, Irene Lisa Vargas, Simone Mcgarry, Oline Chantell Hollmann, Camila Gherardelli, Sofia Sepulveda, Adam T Szafran, Michael A Mancini, Sanne Simone Kaalund, Tomasz Brudek, Lisette Salvesen, Sara Bech, Justyna Okarmus, Peter Kharchenko, Morten Meyer, Claudio Soto, Kristine Freude, Abhisek Mukherjee, Susana Aznar, Konstantin Khodosevich
Faculty, Staff and Student Publications
Multiple system atrophy (MSA) is a rare, age-related neurodegenerative disease that shares clinical and pathological features with Parkinson's disease (PD) but presents a more devastating disease course. To elucidate the distinct cellular pathophysiology, we performed single-nucleus RNA sequencing on postmortem striatal brain tissue from 7 MSA and 12 PD patients, and 10 non-neurological cases. Here, we show significant compositional differences in astroglia and microglia subtypes, while oligodendroglia and neurons are comparable. PD brains show abundant microglia expressing MHC class II HLA haplotypes, indicative of a proinflammatory state, alongside more homeostatic astrocytes. In contrast, MSA lack activated microglia but has more …
Decoding Immunotherapy Response Through Computational Modeling, Bingrui Li, Ruihan Luo, Kexin Huang, Jiajia Liu, Weiling Zhao, Xiaobo Zhou
Decoding Immunotherapy Response Through Computational Modeling, Bingrui Li, Ruihan Luo, Kexin Huang, Jiajia Liu, Weiling Zhao, Xiaobo Zhou
Faculty, Staff and Student Publications
Immunotherapy has seen success in treating patients with cancer, but variable responses underscore the need for effective patient stratification and therapy planning. Computational tools integrating multi-omics, imaging and machine learning have advanced, yet reliable personalized predictions remain challenging. This review analyzes the field through four converging paradigms: classical machine learning, deep learning, graph and network modeling, and mechanistic systems biology. We examine the evolution from correlational features to representation learning, relational inference, and causal simulation of tumor-immune dynamics, highlighting the shift towards multi-modal fusion and interpretable, clinically deployable models. By providing an integrated review of these computational tools, we hope …