Digital Commons Network^™

Genome-Wide Association Study Of Copy Number Variations In Parkinson’S Disease, Zied Landoulsi, Ashwin Ashok Kumar Sreelatha, Nicole Kuznetsov, Claudia Schulte, Dheeraj Reddy Bobbili, Ludovica Montanucci, Costin Leu, Lisa-Marie Niestroj, Emadeldin Hassanin, Cloé Domenighetti, Pierre-Emmanuel Sugier, Milena Radivojkov-Blagojevic, Peter Lichtner, Berta Portugal, Connor Edsall, Jens Krüger, Dena G Hernandez, Cornelis Blauwendraat, George D Mellick, Alexander Zimprich, Walter Pirker, Manuela Tan, Ekaterina Rogaeva, Anthony Lang, Sulev Koks, Pille Taba, Suzanne Lesage, Alexis Brice, Jean-Christophe Corvol, Marie-Christine Chartier-Harlin, Eugenie Mutez, Kathrin Brockmann, Angela B Deutschländer, Georges M Hadjigeorgiou, Efthimos Dardiotis, Leonidas Stefanis, Athina Maria Simitsi, Enza Maria Valente, Simona Petrucci, Letizia Straniero, Anna Zecchinelli, Gianni Pezzoli, Laura Brighina, Carlo Ferrarese, Grazia Annesi, Andrea Quattrone, Monica Gagliardi, Lena F Burbulla, Hirotaka Matsuo, Akiyoshi Nakayama, Nobutaka Hattori, Kenya Nishioka, Sun Ju Chung, Yun Joong Kim, Lukas Pavelka, Pierre Kolber, Bart Pc Van De Warrenburg, Bastiaan R Bloem, Andrew B Singleton, Dan Vitale, Mathias Toft, Lasse Pihlstrom, Leonor Correia Guedes, Joaquim J Ferreira, Soraya Bardien, Jonathan Carr, Eduardo Tolosa, Mario Ezquerra, Pau Pastor, Karin Wirdefeldt, Nancy L Pedersen, Caroline Ran, Andrea C Belin, Andreas Puschmann, Carl E Clarke, Karen E Morrison, Dimitri Krainc, Matt J Farrer, Dennis Lal, Alexis Elbaz, Thomas Gasser, Rejko Krüger, Manu Sharma, Patrick May

Faculty, Staff and Student Publications

We investigated the role of copy number variations (CNVs) in Parkinson's disease (PD) using genotyping data from 10,815 patients (2731 early-onset PD, EOPD) and 8901 controls from the COURAGE-PD consortium. CNVs were analyzed using a sliding window genome-wide association and burden approach. No genome-wide significant CNVs were detected in the overall cohort, but a robust deletion spanning exons 2-6 of PRKN was identified in EOPD cases, validated by MLPA, and replicated in the GP2 dataset (23,089 cases, 18,824 controls). CNV burden was significantly enriched in PD-related genes, primarily driven by PRKN, with the strongest effect observed in EOPD. PRKN CNV …

Sleep Disturbance Trajectories In Critically Ill Children Post-Icu Discharge: A Longitudinal Observational Study, Wenchao Wang, Xiaorui Fan, Yuxia Yang, Jos M. Latour, Guoping Lu, Ying Gu

School of Nursing and Midwifery

Background/Objectives: Sleep disturbances have an impact on children’s physical and psychological development, yet little is known about the changes and factors influencing sleep after PICU discharge. To explore the trajectory of changes in sleep quality of critically ill children and to identify factors affecting sleep quality three months after Pediatric Intensive Care Unit (PICU) discharge. Methods: A longitudinal observation study was conducted between November 2022 and November 2023 at a tertiary children’s hospital. The Children’s Sleep Habits Questionnaire (CSHQ) was used at six time points: PICU-admission (T0), 1 week (T1), 2 weeks (T2), 1 month (T3), 2 months (T4), and …

Stress-Induced Il-6 Response Patterns Amplify The Link Between Daily Negative Affect And Later Depressive Symptoms During Bereavement, E Lydia Wu-Chung, Daniel L Argueta, Robert Suchting, Ryan L Brown, Michelle A Chen, Angie S Leroy, Kyle W Murdock, Cobi J Heijnen, Christopher P Fagundes

Faculty, Staff and Student Publications

Depressive symptoms frequently follow exposure to major life stressors, such as spousal bereavement. However, long-term mental well-being varies considerably. Previously, daily negative affect significantly predicted future depressive symptoms. Higher daily negative affect may signify worse long-term mental health for individuals who also show enhanced inflammatory responses to acute stress, as heightened physiological reactivity to acute stress has been linked with increased susceptibility to depression. Among widow(er)s, we examined whether stress-induced inflammatory responses altered the magnitude of the association between daily negative affect and future depressive symptoms. In exploratory analyses, we examined whether these patterns differed between bereaved and nonbereaved adults. …

Efficacy Of Homemade Botanical Insecticides Against Diamondback Moth (Plutella Xylostella) And Cabbage Aphids (Brevicoryne Brassicae) On Brassica Crops, Nancy Munyoki, Edward N. Karanja, Komivi S. Akutse, Noah Adamtey, Martha Musyoka, Komi K. Fiaboe, David Bautze, Edwin Nderitu, Felix Matheri, Dubois Thomas, Milka Kiboi, Chrysantus M. Tanga

All Peer-Reviewed Publications

The growing need for accessible alternatives to synthetic insecticides has renewed interest in farmer-made botanical formulations for pest management. This study evaluated the efficacy of selected homemade botanical insecticides against diamondback moth (Plutella xylostella) and cabbage aphid (Brevicoryne brassicae) on cabbage (Brassica oleracea var. capitata) and kale (B. oleracea var. acephala) under laboratory and semi-field conditions. Three homemade formulations were assessed: a one-day-old multi-plant extract with neem (Azadirachta indica; PE + N), a one-day-old extract without neem (PE), and a fourteen-day-old, fermented extract without neem (PE14). These were compared with three commercial botanical products. In replicated leaf- and plant-based bioassays, …

Vascular Responses To Hand Posture Are Preserved Despite Acute Endothelial Dysfunction: Insights From Pulse Wave Velocity And Finger-To-Finger Timing, Zain Al-Abideen Falah Ali, Fezaa Shalal Neda, Bassam Talib Al-Gailani

Baghdad Science Journal

Limb posture alters hydrostatic pressure and vascular tone through mechanical and reflex pathways, but the contribution of endothelial function remains uncertain. To determine whether vascular responses to hand elevation and dependency persist during transient endothelial dysfunction induced by ischemia–reperfusion injury (IRI), eighteen healthy adults (9 males, 9 females) underwent ECG-gated pulse recordings at three hand positions: heart level (H-0°), 90° below (H-90°), and 50° above (H+50°), before and after IRI. Primary outcomes were pulse wave velocity (PWV) and finger-to-finger pulse arrival-time difference (f–f ΔT); secondary outcomes were wrist mean blood pressure (MBP), heart rate (HR), and ΔPWV/ΔBP slope. The result …

Video Summarization Based On The Difference In Statistical Histograms Of Fuzzy Clustering Features, Ekhlas Falih Naser

Baghdad Science Journal

The quantity of video footage produced has skyrocketed in the last several years. The enormous increase in video content creates issues with content management. Video and image processing technologies need to receive greater attention to handle the increasing number of videos on the internet and to extract reliable information from them. Video summaries offer concise and streamlined depictions of the content of a video stream. This research aimed to build a methodology for video summarization utilizing the difference in the histogram of video frames using three stages. Frames were elicited from the video, and then SIFT detectors were utilized in …

Astrocyte Circadian Regulation In Neurodegeneration: In Vivo Bmal1 Occupancy Mapping Using Macs-Calling Cards, India Reiss

Arts & Sciences Graduate Student Theses and Dissertations

Astrocytes maintain neuronal homeostasis through cellular programs that are frequently disrupted early in neurodegenerative disease, many of which are regulated by the circadian clock. The core clock transcription factor BMAL1 is required for normal astrocyte function, yet whether its regulatory activity is altered during neurodegeneration remains unclear. BMAL1 expression changes in disease are often inconsistent, suggesting that transcription factor binding, rather than expression, may be a more informative readout of BMAL1 function. We used a Cln3Δex7/8 model of neurodegeneration, which exhibits early astrocyte dysfunction prior to widespread neuronal loss, to test whether degenerative pathology reprograms BMAL1 binding in astrocytes. We …

Shu World Review- April 20th 2026, Diplolab, Seton Hall University

SHU World Review

No abstract provided.

Judging Requires Judgment, Justin Driver

Duke Law Journal

No abstract provided.

Presidential Administration After Arthrex, Noah A. Rosenblum, Roderick M. Hills Jr.

Duke Law Journal

The federal government employs over 2 million civilian workers, all but a few thousand of whom enjoy forms of tenure and insulation from presidential control. This bureaucracy, sometimes called "the administrative state," is organized in a many-layered structure defined by statutes and regulations. Pursuant to law and court decisions, the administrative state routinely makes findings of fact, policy determinations, and conclusions of law, sometimes independent of the president. The Supreme Court's recent decision in United States v. Arthrex risks unsettling this arrangement. It adopts a simplistic, hierarchical vision of bureaucratic organization, which is frankly incompatible with existing statutes and regulations. …

Restoring Chevron Deference By Statute, Scott Dodson

Duke Law Journal

This Essay details a solution for legislatively restoring Chevron deference: amend the APA to direct lower federal courts to give deference to reasonable agency decisions but retain nondeferential judicial review by the U.S. Supreme Court. This solution restores most of the practical benefits of Chevron by giving agencies flexibility to implement congressional policy directives with the expertise they have acquired, by maintaining stability in administrative regulation, and by relieving lower federal courts of the burdens of nondeferential review. And retaining nondeferential judicial review in the Supreme Court will preserve the constitutional role of the judicial branch to say what the …

Ramifications Of Not Digitalising Registries And Records Centres In Civil Service In Zambia, Glenda Ntalasha, Tuesday Bwalya, Chrispin Hamooya, Sututu Imasiku, Kadeyo Mutale Kuyela, Dalitso Mvula, Matilda Mercy Muchinga

Library Philosophy and Practice (e-journal)

Digitalisation of records management among other things, improves access to records and results in efficiency and effectiveness in the functions of an organisation. Because of the potential benefits of digitalisation, several governments globally have automated registries and records centres. However, governments in the Global South, Zambia inclusive have not digitalised the records sub sector. This study investigated the consequences of not digitalising registries and records centres in public service in Zambia. A survey research design was used combining both quantitative and qualitative research techniques. Data was collected from a sample 118 respondents and key informants. Qualitative data was collected through …

Monopsony In Academia And The Gender Pay Gap: Evidence From California, Zhanhan Yu, Alfonso Flores-Lagunes

Upjohn Institute Working Papers

We investigate monopsony power in a highly skilled labor market made up of tenure-ranked faculty in the University of California system, and analyze differential monopsony power exposure by gender. We infer the campus-level labor supply elasticity by estimating the elasticity of separations utilizing individual-level faculty data and two instruments based on campus revenues and salary scales. We find that the “exploitation rate,” a common measure of monopsony power, is about 7% for tenure-ranked faculty. There is a statistically significant difference in the monopsony power experienced by male and female faculty that appears to account for a relatively small percentage of …

Cosmopolitical Trans-Temporalities: Relational Landscapes, Shamanism And Indigenous Futurism In Southeast Asia, Ivan Tacey

School of Law, Humanities and Social Sciences

In Southeast Asia, Indigenous worlds have long been shaped through entanglements with outsiders. But how do such relations intersect with shamanic, place-making, and mythopoetic practices? This paper explores how the cosmopolitical engagements of the Batek of Malaysia unsettle colonial mappings of land, history, and identity, while creating space to contest environmental degradation, economic marginalisation, and political exclusion. It traces how origin myths are tied to land claims, how animist imaginations echo pre-colonial and colonial encounters, and how cosmopolitical practices appropriate foreign imagery and transform traumatic histories. Rather than viewing Indigenous actors as locked in the past–or cosmopolitics as a clash …

Lotilaner Ophthalmic Solution 0.25% In The Treatment Of Demodex Blepharitis: A Case Report, Paul Karpecki, Brandon Ayres, Eric Donnenfeld, Marjan Farid, Ian Benjamin Gaddie, Preeya K Gupta, Cecelia Koetting, Richard Lindstrom, Selina Mcgee, Kelly K Nichols, Laura M Periman, Stephen Pflugfelder, Christopher Starr, Nandini Venkateswaran, Elizabeth Yeu

Faculty, Staff and Students Publications

Demodex blepharitis is a chronic inflammatory ocular condition caused by Demodex mite infestation of the eyelid that can negatively impact quality of life. Currently, lotilaner ophthalmic solution 0.25% is the only FDA-approved treatment for Demodex blepharitis. The Demodex Expert Panel on Treatment and Eyelid Health has established consensus that lotilaner ophthalmic solution 0.25% should be considered the preferred first-line treatment for Demodex blepharitis. We report a patient who presented with collarettes, the pathognomonic sign of Demodex blepharitis, meibomian gland dysfunction, and poor visual acuity. The patient also had a history of neovascular age-related macular degeneration. Consistent with the Demodex Expert …

First, Do No Trend: Aligning Parenteral Lipid Therapy With Physiology And Evidence In Neonates, Parvesh Mohan Garg, Srinivas Bolisetty, Camilia R Martin, Muralidhar H Premkumar

Faculty, Staff and Students Publications

Lipid injectable emulsions (ILE) are essential components of parenteral nutrition in neonatal intensive care units. Over the past two decades, the expanded availability of ILE has led to rapid changes in clinical practice, largely driven by concerns about intestinal failure–associated liver disease. Despite these evolving trends, the evidence supporting one ILE over another remains limited and nuanced. Importantly, no currently available ILE replicates the intrauterine supply of critical long-chain polyunsaturated fatty acids, particularly arachidonic acid and docosahexaenoic acid, both of which decline postnatally regardless of emulsion type. Neonates requiring ILE represent a heterogeneous population of preterm and term infants, with …

Trends In The National Resident Matching Program: Shifting Applicant Priorities In The Setting Of Application Limits And Pass/Fail Step 1 Grading, Joshua Morrow, Siena Blackwell, Zibi Gugala, Atul Maheshwari, Peter Boedeker

Faculty, Staff and Students Publications

Purpose: This study evaluated differences in expected and observed proportions of activities, average Step 2 scores, and abstracts, publications, and presentations since the adoption of a 10-experience maximum for residency applications and pass/fail Step 1 grading.

Method: The authors queried National Resident Matching Program data for MD senior applicants from 2016 to 2024 across 22 specialties. Data included average Step 2 scores; research, work, and volunteer experiences; and number of research products for matched and unmatched students by specialty. Repeated-measures multilevel models were used to estimate the difference in observed outcome in 2024 and expected outcome based on trends from …

Development Of 6-Week Tier 2 Intervention Tracks Within An Elementary Mtss Framework, Maxwell Lyle

Capstone Projects

The Multi-Tiered System of Supports (MTSS) is designed to provide levels of support with differing intensity that align with student needs. Tier 1 is universal instruction provided to all students in the classroom. Students who do not demonstrate adequate progress may receive Tier 2 interventions, which are primarily small-group and, when appropriate, individual interventions that are skill-specific, time-bound (6–8 weeks), and include progress monitoring. Students who do not respond to Tier 2 may require Tier 3 supports, which are intensive, individualized interventions. Many school systems lack consistent, structured Tier 2 supports, particularly in Occupational Therapy-related skills, such as fine motor …

From Browsing To Building: Navigating Your Google Resource Space (Drive & Site), Libby Cunningham

Capstone Projects

This capstone project aimed to develop a trauma-informed, evidence-based support hub for Court Appointed Special Advocates (CASA) working with children involved in the foster care system. CASA advocates are frequently exposed to secondary trauma, burnout, and compassion fatigue, which can impact their effectiveness and overall well-being. Additionally, trauma exposure significantly affects children’s emotional regulation, behavior, and participation in daily occupations. The primary objective of this project was to design, develop, and organize a comprehensive digital resource platform tailored to the needs of Kalamazoo CASA and their active cases. Utilizing evidence-based literature on trauma-informed care and secondary trauma, relevant resources were …

The Missing Link Between Occupational Therapy And Hemodialysis: Program Development And Implementing Intradialytic Ot In A Rural Hospital Setting, Madison Maki

Capstone Projects

Occupational therapy (OT) has demonstrated effectiveness in supporting individuals undergoing hemodialysis, a life‑altering yet lifesaving treatment for end‑stage renal disease (ESRD) and chronic kidney disease (CKD). Despite this, hospitalized patients who require dialysis often receive reduced rehabilitation services due to the time‑intensive nature of dialysis and the productivity demands placed on therapists. Additionally, gaps in therapist knowledge regarding the unique functional deficits and educational needs of this population further limit service delivery.

This doctoral capstone project (DCE), conducted at Upper Peninsula Health System (UPHS), a hospital in rural Northern Michigan, addressed these barriers through the development of a comprehensive resource …

Addressing Barriers To Occupational Therapy Access For Foster Youth Through Advocacy And Education, Josephine Sanders

Capstone Projects

Occupational therapy (OT) is well positioned to support regulation, sensory processing, and participation in daily activities, yet its role in trauma-informed care is often underrecognized. Foster youth experience disproportionately high rates of trauma exposure, which can affect emotional regulation, behavior, relationships, and participation in meaningful occupations. Despite these needs, barriers within healthcare systems and limited awareness of OT’s role often prevent foster youth from accessing services.

This doctoral capstone experience focused on increasing access to OT for foster youth through advocacy, education, and advanced clinical learning and practice. The experience took place at CAYA Therapies in Grand Rapids, Michigan, where …

Susan Kerr V. County Of Allegheny

2026 Decisions

USDC for the Western District of Pennsylvania

Stricturing Diseases Of The Gastrointestinal Tract—Current Clinical Practice, Monjur Ahmed

Division of Gastroenterology and Hepatology Faculty Papers

Gastrointestinal stricture can occur in the esophagus, stomach, small intestine, colon, and anorectum. Most of the strictures are benign. The prevalence of esophageal strictures (ES) secondary to eosinophilic esophagitis has increased. Pyloric stenosis (PS) is rarely seen in clinical practice. Sleeve stenosis (SS) and stomal stenosis or gastrojejunal anastomotic stricture (GJAS) are increasingly seen due to bariatric surgery. Crohn's disease (CD) remains a significant challenge even in the biologic era. The symptomatology of strictures depends on the location, severity, and underlying cause. Imaging studies and endoscopic procedures are the primary investigations to diagnose and evaluate strictures. Various treatment modalities are …

Book Review: Hopeful Visions, Practical Actions: Cultural Humility In Library Work Edited By Sarah R. Kostelecky, Lori Townsend, And David A. Hurley, Gina Mik

School of Information Student Research Journal

No abstract provided.

Book Review: Academic Librarian Burnout: Causes And Responses Edited By Christina Holm, Ana Guimaraes, And Nashieli Marcano, Brianna Gaffney

School of Information Student Research Journal

No abstract provided.

Deklarasi Nasional Hak-Hak Asasi Manusia Sebagai Perwujudan Komitmen Nasional Indonesia Terhadap Pengembangan Dan Perlindungan Hak-Hak Asasi, Hadi Wayarabi

Jurnal Hukum & Pembangunan

Abstract

Social Media Roi: A Case For Reconceptualisation, Daniel Nkrumah, Rose Adjei Asamoah, Roselyn Tanowaa Tanor

Global Advances in Business Communication

Return on Investment (ROI) is a valuable business parameter that measures profitability following an investment. For many corporate organisations, ROI is vital, and in corporate communication, Return on Investment indicates whether advertising and promotional activities are generating the required sales lift. This paper assesses the concept of ROI in corporate communications, with a particular focus on social media Coca Cola. The question that is asked is whether the social media advertising and promotional activities are producing the required sales lift. Using selected case studies, the paper examines the impact of social media promotional activities on the sales and patronage of …

Carrying The Call: A Literature Review On Pastoral Burnout, Nisaa Robinson

College of Arts and Cultural Studies

This literature review examines theory and practice related to the leadership challenge of burnout among Black full-time pastors serving mid—sized urban churches in the Midwestern United States. Utilizing 21 sources across peer—reviewed, professional, popular, and action—network literature, the review applies pragmatic and interpretive research philosophies to evaluate contributing and mitigating factors, conceptual frameworks, validated assessments, and leadership practice implications. The review synthesizes foundational literature, clergy—specific extensions, and culturally responsive scholarship to identify evidence—based insights. Significant gaps in culturally specific, regionally disaggregated research are identified, with implications for future inquiry and organizational leadership practice.

Creating An Enabling Environment For Digital Learners In Higher Education In Uganda, Patricia Isabirye, Mary-Anne Isabirye

Howard University Journal of African Studies (HUJAS)

The COVID-19 pandemic severely disrupted learning in various institutions in Uganda, which saw the temporary closure of tertiary institutions and the adoption of digital learning, which posed access challenges especially for under-privileged groups. Uninterrupted learning was hampered in various forms for university students due to the lack of affordable digital tools for majority of these learners, inadequate digital facilities within tertiary institutions, and the temporary halt of contact classes by the government. The article explores challenges and opportunities experienced because of the digital approach to learning in Uganda, and proposes user-friendly but affordable solutions to digital literacy, while promoting equitable …

Fairhiveframes-1k: A Public Fair Dataset Of 1265 Annotated Hive Frame Images With Preliminary Yolov8 And Yolov11 Baselines, Vladimir Kulyukin, Reagan Hill, Aleksey Kulyukin

Computer Science Faculty and Staff Publications

In precision apiculture, the portable digital camera is a cost-effective sensor for capturing hive images or videos used to quantify different colony variables. Openly accessible, well-annotated, interoperable cell-level image datasets are still the exception rather than the norm. This shortage constitutes a major barrier to AI-driven approaches aimed at automating image-based comb analysis. In this article, we present FAIRHiveFrames-1K, a publicly available dataset of 1265 annotated hive frame images (1920 × 1080 PNG) designed to facilitate research in AI-intensive image-based comb analysis automation. The dataset, derived from a 2013–2022 U.S. Department of Agriculture–Agricultural Research Service multi-sensor research reservoir, includes 124,669 …