Digital Commons Network^™

New Ways To Address The Plastic Problem, Andrew J. Hanna

The Penguin Review

Since 1950, the world has produced some 9.2 billion metric tonnes of plastic.1 Other sources place the total closer to ten billion metric tonnes Furthermore, nearly 500 million tonnes of new plastic are manufactured each year– a figure that's projected to increase to 1.2 billion tonnes by 2060.2 The environmental effects of all this plastic production and pollution are disturbing. Because most plastics are synthetic–meaning they contain "no molecules found in nature"– they can't decompose. Instead, they just break down into smaller and smaller pieces, becoming microplastics (less than five millimeters (5 million nanometers) across) and then nanoplastics (less than …

Ethical Discernment In Virtual Supervision: Implications For Supervisory Practice, Joshua Freeman

Liberty University Research Week

As counselor supervision increasingly occurs in virtual settings, supervisors must attend not only to ethical standards and professional judgment, but also to how technology reshapes communication, relational dynamics, and ethical interpretation. Virtual environments alter the conditions under which supervisory presence, power, and meaning-making are experienced, introducing new ethical complexities, especially when addressing values, spirituality, and religious worldviews in clinical work. This presentation advances a conceptual framework positioning ethical discernment as a primary mediating process in virtual supervision. Drawing from the Discrimination Model of supervision and professional ethical standards, the framework integrates supervision theory, ethical decision-making, spirituality, and worldview considerations within …

Transforming Patient Safety And Care Practices Through Interprofessional Education, Kaleena Ramirez, Claudia C. Tamara, Jennifer Sells, Karen Clatt, Banan Abuharb, Mary Coolbaugh-Murphy, Iris Culwell, Anca Fumurescu, Mary Gust, Lori Simmons, Delores Whiteing, Annie Koenig, Sara Martinez, Wilton Muriithi, Shaun T. Caldwell, Susan Lee, Mary Sizemore, Kimberly Ann H. Krumwiede

Advances in Cancer Education and Quality Improvement

As healthcare increasingly relies on interdisciplinary teams to deliver safe and effective care, the development of interprofessional collaboration competencies among students in health care professions has become an educational priority. In response, The University of Texas MD Anderson Cancer Center School of Health Professions integrated a longitudinal interprofessional education curriculum to foster collaborative practice readiness and prepare students for team-based interdisciplinary environments that ensure safe and patient-centered care. The curriculum was guided by the Interprofessional Education Collaborative 2016 and 2023 core competencies for interprofessional collaborative practice, reinforced with the Real Colors® Personality Instrument and Team Strategies and Tools to Enhance …

Windshield Not The Rearview Mirror, Dan Fabricant

Oxford ICSB

We talk a great deal about the past at ICSB and while the history is important, we still need to skate to where the puck is going. We’ll tee up where we are and where we are going when it comes to: drug preclusion; federal preemption; state regulatory efforts; hemp/cannabis; electronic commerce platforms; claims; essentiality; and much more, like what you can do to affect real change for the future of the industry.

Functional Genomics Of Streptococcus Mutans: Identifying Critical Genes For Oral Biofilm Formation, Cara E. Pirani

Create@State

Streptococcus mutans (S. mutans) is a pathogen found in the human oral cavity that plays a central role in the development of dental caries, or tooth decay. This pathogen thrives on the sugars consumed in the diet, contributing to the breakdown of tooth enamel, especially in the presence of poor oral hygiene. S. mutans produces a glycosyltransferase enzyme that converts sucrose into the polysaccharide glucan. Glucan allows the pathogen to attach to the enamel of the tooth and begin metabolizing the sugar on the teeth, resulting in lactic acid. The acid under the biofilm layer lowers the pH of the …

A Cord Of Three Strands Is Not Quickly Broken: The Fortitude Of Arkansas Women's Activism, Laura L. Hennings

Create@State

Mainstream attention to Arkansas women’s activism often emphasizes work that aligned with the status quo, rather than subverting it. The key figures in this project were mothers who advocated for improvements to public health, education, and justice reform, and non-parent maternal figures who hoped to make life more equitable for all families. I scoured over one thousand pages of primary and secondary source material to determine those factors that were most vital to the successes of organizations such as the Women’s Emergency Committee, the Southern Tenant Farmer’s Union, and the Association of Southern Women for the Prevention of Lynching. Within …

Comparison Of Levels Of Bmi, Stress, And Depression Of Women During The Prenatal Period Relative To Their Activity Levels, Kalayna King

Create@State

This study aimed to analyze the relationships between activity levels, Body Mass Index (BMI), stress levels, and depression symptoms in obese pregnant women in Arkansas. Two separate exercise intervention studies were combined in this analysis to ultimately give a sample size of 293 pregnant women who were randomized into standard of care group (control) and an exercise group (experimental) (n = 115 and n = 178, respectively). Women in the control groups were instructed to independently continue to follow the physical activity guidelines recommended by their gynecologist, whereas the experimental groups participated in a combination of aerobic and resistance exercise …

Investigating Sertraline‑Mediated Modulation Of Succinate Dehydrogenase To Sensitize Tmz‑Resistant Glioblastoma Cells, Supraja Mallapuram

Create@State

Glioblastoma (GBM) is one of the deadliest and most common brain tumor which remains highly resistant to temozolomide (TMZ), contributing to poor patient outcomes. Literature suggests that sertraline, a widely used SSRI, disrupts mitochondrial metabolism in cancer cells. Because GBM depends heavily on succinate dehydrogenase (SDH) for oxidative phosphorylation, sertraline‑mediated SDH inhibition may increase metabolic stress and reduce functional TMZ resistance. This poster presents a literature‑based rationale and proposed experimental design to evaluate sertraline‑induced SDH modulation and its potential to sensitize TMZ‑resistant T98G glioblastoma cells. These findings will guide future experimental work.

Inhibitory Effects Of Novel Compounds On Biofilm Formation In Streptococcus Mutans, Graysen S. Jones

Create@State

Inhibitory Effects of Novel Compounds on Biofilm Formation in Streptococcus mutans

Purr-Spectives: Connections Between Feline Coat Color And Human Preferences And Perceptions In Northeast Arkansas, Tiffany L. Batchelor

Create@State

Felines have played an important role in the lives of humans for thousands of years. This study investigated perceptions of felines and feline demographics in Northeast Arkansas (NEA). For Study 1, data on phenotype and health conditions was collected from 2,305 patient files from three NEA veterinary clinics. For Study 2, an anonymous survey generated using Qualtrics was published through College of Agriculture social media accounts to gather opinions from cat owners on feline coat color and ownership trends. Study 1 identified up to 6 pattern-based and up to 18 color-based phenotypes per clinic and a total of 129 unique …

Impact Of Cover Crop Species And Planting Date On Earthworm Abundance And Biomass, Sowmya Thadisina, Maheshwari Saddollu

Create@State

Cover crops help to enhance soil structure, increase soil organic matter, and increase soil biological activity in agricultural systems. Earthworms are beneficial bioindicators of soil health as they enhance soil aggregation, aeration, and nutrient cycling. Understanding the influence of cover crop species and planting date helps optimize soil biological activity.

Prioritizing Health Over Aesthetics: Reforming Brachycephalic Breed Standards, Olivia Edwards

Create@State

Selective breeding has led to extreme physical traits in companion animals such as dogs and cats. They are characterized by their shortened skulls, creating their flattened faces. These breeds remain fairly popular due to their appearance, even though these animals present various health concerns.  I conducted this research at A-state to create awareness and educate those who are not aware of this issue, and for future pet owners. It argues that the continued promotion and recognition of these animals contributes to preventable health conditions and long-term suffering in affected animals. I analyzed reports on animal welfare, reviewed policy discussions and …

Synthesizing Fluorescent 3,4-Dihydropyrimidin-2(1h)-Ones Using A One-Pot Synthesis Reaction, John R. Griggs

Create@State

In medical and pharmaceutical practices, Biginelli (3,4-dihydropyrimidin-2(1H)-ones) products have a number of potential uses due to their anticancer and anti-inflammatory properties.  In addition, they are a possible treatment for acquired immunodeficiency syndrome (AIDS). These compounds can be further modified to exhibit fluorescent properties. However, before using them in medicinal studies, it is useful to establish a procedure that can easily be modified and is synthetically accessible to allow for further optimization. The experiment was performed using the Biginelli compounds as a substrate, along with a variety of aromatic aldehydes and acids. After obtaining the products and purifying them with vacuum …

Student Perspectives On The Selection And Suitability Of Emotional Support Animals, Ella G. Speer

Create@State

Emotional support animals (ESA) are classified as any species of animal that provides cognitive and emotional benefits for individuals struggling with mental health impairments (Ferrell, Crowley 2021, p. 561). Emotional support animals differ from service and therapy animals because there are no restrictions regarding the specie selection if the owner perceives their benefits (Ferrell, Crowley 2021, p. 561). Relaxed regulations on the specie of emotional support animals allow individuals the opportunity to choose any animal based on their perceived benefits (Pettable Staff, Fleming 2024). Recently, universities have implemented an emotional support animal policy to protect students who live on campus …

Amyloid Beta-42 Neurotoxicity In Drosophila Retinal Development, Shay O. Sims, Pierce Duncan, Malachi Abon, Jacob G. Smith

Create@State

Alzheimer's disease (AD) represents one of the most prevalent neurodegenerative disorders globally. Thus far, the underlying mechanisms associated with the pathogenesis of AD are innately elusive. Two hallmarks associated with the progression of AD exist, including Amyloid-Beta 42 (Aβ42) protein plaque formation and hyperphosphorylation of tau proteins in neurons. Amyloid-beta is known to concentrate with other neuronal proteins as complexes form, including the cytoskeletal protein actin. However, whether actin contributes to neuronal decline in AD is unknown. To further understand the cellular cascades associated with AD, we investigated the role of cytoskeleton dynamics in modulating oxidative stress and neuroinflammation within …

Mental Health In Healthcare Workers: Is It Just A Myth Or A Fact, Considering The Abundant Access To Healthcare, Shiwani Ranjitkar

Create@State

Healthcare workers have direct access to healthcare resources, yet many continue to experience significant mental health challenges. This study investigates the factors contributing to this issue and its implications for healthcare systems. Using data analysis and a review of recent literature, national surveys, and public health reports, key factors identified include heavy workloads, emotional strain from patient care, staffing shortages, workplace harassment, and stigma associated with seeking mental health support. Research indicates that healthcare professionals frequently experience burnout, anxiety, depression, and compassion fatigue even when support resources are available. For instance, data from the Centers for Disease Control and Prevention …

Transgenic Plant Cells For The Cost-Effective Production Of Pharmaceutical Proteins, Maria Gambaro

Create@State

Plant-based systems are becoming an important method for producing pharmaceutical proteins because they can be more cost-effective, and safer compared to traditional production methods which commonly use mammalian cells. This project aims to develop a transgenic plant cell system that can produce a pharmaceutical protein using molecular cloning techniques. A transgenic plant cell has the DNA of another plant integrated into its genome, altering its gene expression to produce different proteins. To begin, a plasmid carrying the gene of interest and the DNA components needed for expression will be designed. The plasmid will then be used to introduce the gene …

Relish As A Temporal Switch In Neurodegeneration Using Drosophila Melanogaster, Kyle M. Johnson

Create@State

Neurodegenerative diseases are often linked to chronic inflammation in the nervous system, but it is still unclear what triggers this process during the early stages of disease. This project examines whether activation of the NF-κB transcription factor Relish may act as a temporal switch that contributes to early neurodegenerative stress in Drosophila melanogaster. As a result of many innate immune pathways are consistent between flies and humans, Drosophila serves as a useful model for studying how immune signaling affects neuronal health. In this study, neural driver lines were crossed with control strains to evaluate how changes in Relish signaling …

An Investigation Into Relish Activation As A Temporal Switch In Neurodegeneration, Kyle M. Johnson

Create@State

Neurodegenerative diseases are often linked to chronic inflammation in the nervous system, but it is still unclear what triggers this process during the early stages of disease. This project examines whether activation of the NF-κB transcription factor Relish may act as a temporal switch that contributes to early neurodegenerative stress in Drosophila melanogaster. As a result of many innate immune pathways are consistent between flies and humans, Drosophila serves as a useful model for studying how immune signaling affects neuronal health. In this study, neural driver lines were crossed with control strains to evaluate how changes in Relish signaling …

Understanding The Relationship Between Morphometric Indices Of The Eleven Point River And Sediment And Nutrient Transport, Karimot Shobowale, Jennifer Bouldin

Create@State

Objective: To evaluate how watershed characteristics impact sediment transport and water quality parameters.

The Silent Trigger Theory: A Predictive Behavioral Safety Framework, Yazeed Almutairi

Liberty University Research Week

This theoretical study introduces The Silent Trigger Theory, a predictive behavioral safety framework designed to identify early, often overlooked human signals that precede safety incidents. Despite advances in established safety approaches such as Behavior-Based Safety (BBS), Human and Organizational Performance (HOP), and ISO 45001 management systems, incidents continue to occur in environments where procedures, audits, and controls are fully implemented. This gap suggests a limitation in current models’ ability to capture subtle behavioral warning signs, particularly silence, emotional withdrawal, and ambiguous communication.

The Silent Trigger Theory addresses this gap through the STARC framework (Shift, Traceable, Ambiguity, Risk Link, Corrective Loop) …

A Scoping Review: The Relationship Between Mindfulness, Resilience, And Wellness For First Responders With Work Related Trauma, Gary Oliver

Liberty University Research Week

This study reviewed research that explores the relationship between mindfulness, resilience, and wellness for First Responders with work related trauma. Mindfulness has a basis firmly rooted in Buddhist psychology, and shares similar conceptual tenets with Greek philosophy, existentialism, transcendentalism, and humanism which all center around the consciousness of attention and awareness. Resilience has a variety of interpretations within the literature and is understood as a dynamic process accounting for environmental and psychosocial factors that help people survive, grow, and thrive despite adversity. Wellness, though not concretely defined, is similar to overall health which is defined by the World Health Organization …

Ai-Augmented Music And Emotion Processing: Exploring Whole-Brain Integration In Counseling Sessions, Janita Daggy, Patricia Mcglothlin

Liberty University Research Week

This study explores how AI-adaptive music applications might support emotional awareness and self-regulation when used during counseling sessions. While creative arts interventions have long been recognized for engaging emotion-related brain processes, and AI technologies show promise in providing adaptive, real-time feedback, little research has examined how these approaches work together in actual counseling practice. The study introduces the Neuro–AI–Creative Integration Framework (NACIF) to guide this exploration. Thirty participants will attend five counseling sessions that incorporate AI music applications responsive to their emotional and physiological states, along with therapist-facilitated reflection on their emotional and bodily experiences. The study will measure changes …

Reframing Alpha-Gal Syndrome As A One Health Oral Health Risk: A Theoretical Model For Dental Safety And Policy Reform, Oyebolu Aderinola Akinkugbe, Akuchinyere Titus-Okpanachi, Oluwatosin Marylyn Oduneye

Liberty University Research Week

No abstract provided.

Viral Hepatitis Screening In Early Breast Cancer Patients Receiving Cancer Therapy: A Quality Improvement Initiative, Katherine Klein, Jessica Hwang, Vicente Valero, David Ramirez, Jaime Kaushik

Advances in Cancer Education and Quality Improvement

American Society of Clinical Oncology guidelines recommend screening all patients for hepatitis B virus (HBV) and hepatitis C virus (HCV) before initiation of cancer therapy. Cancer patients receiving cancer therapy represent a vulnerable population, and reactivation of undetected hepatitis virus can lead to devastating consequences. At MD Anderson Cancer Center, rates of hepatitis screening for all cancer patients have been historically low. The overall aim of this quality improvement (QI) study was to increase rates of HBV and HCV screening to at least 50% in early-stage breast cancer patients before cancer therapy in the Breast Medical Oncology clinic at MD …

Interprofessional Education Development In An Oncology-Focused Healthcare Institution, Mary Sizemore, Michael Morris, Mohamed Ait Aiss, Gregory Botz, Jolyn Taylor, Joshua Kuban, Diane C. Bodurka

Advances in Cancer Education and Quality Improvement

Background: Despite growing recognition of the value of interprofessional education (IPE), most IPE work has focused on undergraduate learners, leaving a critical gap in postgraduate and clinical environments. This report describes a phase 1, formative, pre-implementation quality improvement (QI) initiative to establish an institution-wide IPE program at an oncology center without a traditional medical school.

Methods: We used a developmental, multiphase mixed methods design integrating 3 inputs: (1) Virtual Interprofessional Teaching and Learning (VITAL) faculty-development feedback, (2) IPE Steering Committee feedback, and (3) simulation evaluation used as an applied context (not the sole focus). Surveys were administered to VITAL participants, …

Spatial Computing With The Apple Vision Pro In Minimally Invasive Procedure Simulation: A Randomized Crossover Feasibility Study, Sydney Cooper, Aaron Kyle Jones, Rahul Anil Sheth, Koustav Pal, Bruno Odisio, Mark Blaylock, Shelita Kimble, Justin Bird, David Rice, Daniel Shoenthal, Emil Patel, Vipin Kamath, Sanjay Gupta, Jeffrey Siewerdsen, Joshua Kuban

Advances in Cancer Education and Quality Improvement

Purpose: This study aimed to evaluate the feasibility of wearing the Apple Vision Pro (AVP), a mixed-reality headset that integrates augmented and virtual reality, while performing minimally invasive procedures. While studies have demonstrated that spatial computing technology can improve surgical precision and reduce the risks of surgical complications, to our knowledge, no studies have specifically addressed the impact of the AVP on task performance during simulated image-guided procedures.

Materials and Methods: Thirteen diagnostic and interventional radiology residents performed image-guided central venous catheter placement, thoracentesis, and paracentesis on simulation models. Each participant completed a non-timed practice followed by the procedures once …

Utilization Of Hybrid Angiography-Ct Suites In An Interventional Oncology Practice, David Irwin, Kiyoyuki Minamiguchi, Ryosuke Taiji, Aaron Kyle Jones, Gouthami Chintalapani, Roland Bassett, Steven Y. Huang, Sanjay Gupta

Advances in Cancer Education and Quality Improvement

Purpose: To evaluate operational trends in an interventional oncology practice at a tertiary academic center before and after the addition of hybrid angiography–computed tomography (Angio-CT) rooms.

Materials and Methods: The procedure volumes and types performed in the hybrid Angio-CT rooms were retrospectively collected from 2016 to 2020. Procedures were divided into categories, including arteriography, endovascular interventional oncology, ablation, venous intervention, non-vascular catheter placement (biliary, nephrostomy, gastrostomy, etc.), and osseous interventions. Procedural trends in the Angio-CT rooms and the frequencies of combination procedures that used both CT and angiography were assessed.

Results: A major shift of catheter-based tumor-directed cases to Angio-CT …

A Performance And Quality Improvement Intervention Integrating Molecular Testing To Support Personalized Cancer Care In Lung And Thyroid Cancers, Suzanne Murray, Monica Augustyniak, John Vu, Elbert Y. Kuo, Manolo G. Pasia Jr., Sheri L. Rivera, Kelly M. Rodriguez, Vivek Subbiah, Patrice Lazure, Ecaterina E. Dumbrava

Advances in Cancer Education and Quality Improvement

Introduction: Molecular testing has been underutilized in the diagnosis and treatment of cancer patients, despite its potential to significantly impact clinical decision-making and resulting health outcomes.

Objectives: This project aimed to evaluate the process and impact of a performance/quality improvement (PI/QI) intervention to optimize the integration of molecular testing for patients with non-small cell lung cancer (NSCLC) or thyroid cancer (TC).

Methods: Physicians, advanced practice providers, and nurses were engaged in the PI/QI at 2 cancer centers (Site A and Site B) for up to 18 months following a pre-intervention needs assessment. Gaps identified at baseline informed …

Tom: Treatment Outcome Monitor - A Web-Based Tool Designed Specifically For Clinics With Limited Resources, Saurabh Shashikumar Nair, Alba Kihn Alarcon, Maritza Elodia Cupil Barrios, Milton Estuardo Ixquiac Cabrera, Mynor Villeda, Joseph Steyn, Anneray Richards, Ricardo Ruggeri, Loida Orozco, Angel Velarde, Indranil Mallick, Graeme Lazarus, Christoph Trauernicht, Vicky De Falla, Tim Edwards, Johnny Inthaphone, Adenike Olanrewaju, Laurence E. Court, Joshua Niedzielski

Advances in Cancer Education and Quality Improvement

Background: Although three-fourths of cancer deaths are expected to occur in low- and middle-income countries (LMICs) by 2030, most cancer research still comes from high-income countries. One barrier to cancer research in LMICs is lack of infrastructure for systematic data collection, including electronic medical record systems. We developed Treatment Outcome Monitor (TOM), a cloud-based tool for tracking cancer patient outcomes, designed specifically for resource-limited settings.

Methods: TOM was developed through iterative design cycles with continuous feedback from health care providers from across the world. We focused on creating a simple, web-based solution that addresses real-world challenges in resource-limited …