Digital Commons Network^™

B Cell Expression Of An Enzymatic Intermediary In Ether Lipid Biosynthesis Promotes Antibody Responses And Germinal Center Size, Sung Hoon Cho, Marissa A Jones, Kaylor Meyer, David M Anderson, Sergiy Chetyrkin, M Wade Calcutt, Richard M Caprioli, Clay F Semenkovich, Mark R Boothby

2020-Current year OA Pubs

The qualities of antibody (Ab) responses provided by B lymphocytes and their plasma cell (PC) descendants are crucial facets of responses to vaccines and microbes. Metabolic processes and products regulate aspects of B cell proliferation and differentiation into germinal center (GC) and PC states along with Ab diversification. However, there is little information about lymphoid-cell-intrinsic functions of enzymes that mediate ether lipid biosynthesis. Imaging mass spectrometry (IMS) results had indicated that concentrations of a number of these phospholipids were substantially enhanced in GC compared to the background average in spleens, but it was unclear if biosynthesis in B cells was …

Evaluating Acridones As Novel Therapeutics For Human Babesiosis, Pratap Vydyam, Elizabeth Zhang, Papireddy Kancharla, Rozalia A. Dodean, Jane X. Kelly

Chemistry Faculty Publications and Presentations

Human babesiosis is an emerging tick-borne disease caused by Babesia parasites, most notably Babesia microti and Babesia duncani in North America and Babesia divergens in Europe. Infections can be severe or persistent or relapse despite treatment, and current therapeutic options remain limited, underscoring the urgent need for new and effective treatment options. Acridone derivatives originally developed as potent antimalarial agents against multiple life cycle stages of the malaria parasites were evaluated for their antibabesial activity using continuous in vitro culture systems of B. duncani and B. divergens. Lead candidates were assessed for selectivity against human cell lines to establish preliminary …

The Echo: April 27, 2026, Taylor University

2025-2026 (Volume 113)

No abstract provided.

Synthesis Of Citrate Based Polyesters, Emma E.C. Buckhalter

Honors Capstone Projects and Theses

No abstract provided.

Jtc 26: Trailblazing Tradition: Choctaw Student Charts Path To Pharmacy, Marisa C. Atkinson

University of Mississippi News

This story is part of the 2026 Journey to Commencement series, which celebrates the pinnacle of the academic year by highlighting University of Mississippi students and their outstanding academic and personal journeys from college student to college graduate.

Transforming Workers' Compensation Into A Workforce Optimization Strategy, Tina Marie Santos, Kathleen Jancek

Creating Healthy Work Environments (CHWE)

Purpose: The personal, physical, and financial toll of workplace injuries on workers is enormous, with many experiencing isolation and depressive symptoms.

Objective: This quality improvement project aimed to improve the Workers' Compensation (WC) program to enhance workforce retention, productivity, team member well-being and reduce liability.

Approach: The project implemented a structured, iterative process grounded in baseline data to inform and refine process improvement and outcomes. Strategies for improvement included: (1) foster professional well-being through an accommodation model that emphasized belonging and meaningful contributions during recovery; (2) creative and flexible solutions leveraging team members' abilities rather than limitations that aligned with …

Evaluation Of Sirna-Mediated Knockdown Of Heat Shock Protein 16.2 In Adult Acropora Cervicornis, Edward P. Gniffke, Benjamin D. Young, Keir J. Macartney, Michael S. Studivan, Ian C. Enochs, Erin E. Easton

School of Earth, Environmental, & Marine Sciences Faculty Publications

Acropora cervicornis is a critically endangered Caribbean coral species facing a precipitous decline due to disease and thermal bleaching. To combat the loss of ecologically important reef-building corals, novel molecular approaches can be used to understand mechanisms of resilience and ultimately provide a means to modulate coral performance. In this study, we tested a recently developed method for gene knockdown in adult corals that utilizes short interfering RNAs (siRNAs) and the RNA interference pathway. The Heat Shock Protein 16.2 (HSP16.2) gene in fragments of adult A. cervicornis was targeted for knockdown using a single siRNA construct. RT-qPCR analysis of HSP16.2 …

The Life Of Richard Henderson Rivers, Nell Peerson

Documents

This article is on the president of LaGrange College and Florence Wesleyan University, Dr. Richard Henderson Rivers. This "paper" was completed as an assignment for Research in the History of Southern Education in 1933.

A Corporation For Artists, Or An Artist’S Corporation?: An Analysis Of Colorado Bill 26-133, Andrea Yang

Cardozo Arts & Entertainment Law Journal (AELJ) Blog

Trade and art have been interlinked since the beginnings of artistic creation. Throughout history, one of the core tensions in the world of creativity has been between the creation of artistic work and economics of survival. With the advent of the internet and social media, democratization in access to the arts has demolished many of the classic gatekeepers that have historically prevented artists from creating and sharing their work. However, artists, musicians, and writers still face significant barriers in obtaining and retaining capital to support their livelihoods, frequently turning to alternate professions to sustain their work.

German Is For You! The Making Of A High School Multikulti German Course, Jennene Aten

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

This teacher self-study examined the process of creating and teaching a multicultural German curriculum. This study necessarily involved observing students as they went through the semester of course work, but students are not the center of the research. I am. This research focuses on what I learned about teaching, specifically my teaching in my subject area and how I could improve my skills and methods.

Germany is an ethnically diverse nation but not usually thought of as such. The presentation of Germany in German language textbooks is generally portrayed as rather monochromatic. Students who study German, specifically in Fairfield, California, …

Improving Drought Science Communication And Accessibility, Lindsay Erin Johnson

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Effective drought management depends not only on the accuracy of scientific data, but also on how that information is communicated and understood by diverse audiences. This dissertation examines drought communication through the lens of science communication, with a focus on improving readability, accessibility, understandability, and usability of drought information. Using a manuscript-style format, three studies investigate how drought information is written, delivered, and applied. Chapter 1 provides a brief overview and outline of this dissertation. Chapter 2 evaluates the readability of the U.S. Drought Monitor (USDM) national narratives over almost 8 years. Results show that these narratives are consistently written …

Making The Case For Spandex: The Nature Of Re-Novicing And The Merging Of Expertise For Former Elementary And High School Teachers Who Move To Teaching At The Middle Level, Elizabeth K. Boyle

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

As an academic coach in a large, Midwestern middle school, I noticed an influx of teachers with years of prior experience at the elementary or high school levels being hired to work with students in grades six through eight. Because they were already veteran teachers, they were not assigned mentorship, yet there were aspects of working in a middle-school setting that effectively “re-noviced” them (Hanuscin et al., 2020).

Knowing that cookie-cutter approaches to professional development and learning often do not meet the needs of adult learners, I sought information that would guide what professional growth opportunities could be provided to …

No Ash Will Burn, Blake Kinnett

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

No Ash Will Burn follows twin narrators Avery and Krista Harmon. After a boy their aged, named Oliver O’Hara, moves in next door, Avie begins playing music with him at the docks in their town. When their mother unexpectedly passes away, Avery leaves their small town of Monticello, Kentucky for Lexington, Kentucky, taking Krista’s dulcimer along with her. The dulcimer was built by their late father, who intended to build two, but passed away before he could complete the second, dedicated to Avery. The completed dulcimer has Krista’s name carved into the side. In Lexington, Oliver develops an original song, …

A Multimodal Approach For Building Generalizable And Reliable Models Of Longitudinal Experiential Data, Ahatsham Hayat

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

This dissertation studies how to build generalizable and reliable models for longitudinal experiential (LE) data. Such data arises in domains where human behavior, experience, and context evolve over time, including education, behavioral health, and related human-centered settings. These datasets are often heterogeneous, partially observed, temporally structured, and vulnerable to out-of-distribution (OOD) shift, making them difficult to model with conventional machine learning pipelines.

The dissertation develops a multimodal research program that progresses from traditional machine learning and deep learning methods to contextual large language modeling, vision-language modeling (VLM), and finally a frozen-backbone multimodal framework designed to improve robustness and generalization. Across …

Impacts Of Supplemental Fat In Finishing Diets On Digestibility, Performance, Carcass Outcomes, Meat Quality And Methane Production Of Feedlot Cattle, Anna Marie Kobza

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Rising costs and fluctuating availability of supplemental fats has led to increased interest in alternative fat sources or feed additives that might improve utilization of supplemental fat in feedlot diets. Two separate experiments were conducted to evaluate alternative strategies to overcome high fat prices. The first experiment was a metabolism study, conducted to evaluate digestion parameters of supplemental fat sources with or without LYSOFORTE Extend. The objectives of this experiment were to evaluate LYSOFORTE Extend in beef finishing diets containing a saturated fat source (tallow) and unsaturated fat source (corn oil). Duodenally and ruminally fistulated steers were fed diets containing …

Integrated Approaches For Valorization Of Chicken Feather Waste: From Extraction To Application Of Keratin-Based Bioproducts, Muhammad Ehtasham Akram

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

This dissertation explores the optimization of chicken feathers keratin hydrolysate (CFKH) production using alkaline hydrolysis (AH) and sub-critical water hydrolysis (SCWH), focusing on acquiring high keratin yield in the hydrolysate. Then, CFKH along with other locally sourced materials, was used to develop bioplastics with regenerative agriculture properties (BioWRAP), with the ultimate objective of applying it as a soil mulch to suppress weeds in agricultural crops. This work also addresses challenges in process design and industrial scale-up of BioWRAP. Chapter 1 is a literature review that introduces terms like biobased, biodegradable, and bioplastics, materials and methods used to make bioplastics, and …

Social Determinants Of Health And Caregiver Mental Health Screening In The Neontal Intensive Care Unit, Chloe Hicks Fisher

Master's Theses (2009 -)

Perinatal mental health conditions affect approximately one in five mothers and one in ten fathers in the United States, and caregivers of newborns admitted to the neonatal intensive care unit (NICU) are at an elevated risk for developing mental health conditions due to the significant stress associated with infant hospitalization. However, not all caregivers complete mental health screenings, raising concern that current protocols may be failing to reach a meaningful subset of this population. Social determinants of health (SDOH) are non-medical factors that influence health outcomes and are known risk factors for mental health conditions in perinatal populations. The present …

Reliability And Validation Of A Game-Based Assessment Of Upper Limb Movement In Children With Unilateral Cerebral Palsy, Rachel Scheele

Master's Theses (2009 -)

Unilateral cerebral palsy (UCP) is a pediatric movement disorder characterized by motor impairment primarily affecting one side of the body. Clinical assessments of upper limb function are widely used but often lack precision and may be influenced by clinician subjectivity, thus creating a need for objective, reliable, and valid forms of assessment. Mobile health (mHealth) has shown promise in rehabilitation settings, due to its accessibility and user-friendly design. However, validity and reliability of these assessment tools remain largely unknown. MoEvGame was developed to evaluate upper limb motor function. This study evaluated the reliability and validity of MoEvGame in children age …

Quality Improvement Project: Improving Adn Faculty Professional Development Through Simulation Training, Sharon Haley Peace

Doctor of Nursing Practice Projects

Lack of structured simulation training for nursing faculty, which has been identified as a gap in the literature, can negatively impact the quality of simulation-based education and student learning outcomes. The purpose of this Doctor of Nursing Practice (DNP) quality improvement project was to develop, implement, and evaluate an evidence-based training intervention aimed at improving faculty self-efficacy and competence in simulation facilitation. The project was guided by Lewin’s Change Theory and Kolb’s Experiential Learning Theory to support faculty development. A quantitative, quasi-experimental pre-post design was used with a convenience sample of nine associate degree nursing faculty at a rural community …

Quality Improvement Project: Improving Provider Workflow And Documentation For Routine Mental Health Screening In An Outpatient Psychiatric Clinic, Sharon Uchechi Joshua

Doctor of Nursing Practice Projects

Depression and anxiety are leading causes of disability and are frequently underdiagnosed in outpatient psychiatric settings due to inconsistent screening and documentation practices. Evidence supports the use of standardized tools, such as the Patient Health Questionnaire-9 (PHQ-9) and Generalized Anxiety Disorder-7 (GAD-7), to improve early detection and clinical outcomes. This quality improvement (QI) project evaluated whether implementing standardized electronic health record (EHR) templates and provider education would improve documentation of PHQ-9 and GAD-7 screenings. The aim was to increase the consistency of screening and documentation among psychiatric providers. The project was guided by the Plan-Do-Study-Act (PDSA) framework and Lewin’s Change …

Expectations And Realities In Primary Care Appointment Access In The United States: A National Study, Brigham Walker, Ethan Tsai, Alexandra Shimanovsky, Edel Doherty, Sarah E. Tinkler, Rajiv Sharma

Economics Faculty Publications and Presentations

Objective: While patients expect timely appointments, little is known about how accurately patient expectations reflect the realities of access to a primary care physician.

Methods: We deployed a national survey (N = 6119, conducted in 2021) to measure patient expectations and a separate national field experiment (N = 11,016, conducted between 2013 and 2016) where trained research assistants called physician offices seeking an appointment to measure physician availability.

Results: Using multivariate regression analyses, we find that patients expected to call 1.9 physicians to secure an appointment, consistent with an appointment offer rate of 49%. However, expectations of 5.4 days wait …

Evaluating Glucagon-Like Peptide-1 Receptor Agonist Safety Before Upper Endoscopy: A Systematic Review And Meta-Analysis, Zohaib Ahmed, Amna Iqbal, Sami Ghazaleh, Abdallah Kobeissy, Ali Nawras, Yaseen Alastal, Hani Saad, Sarmed Mansur, Idrees Mohiuddin, Umair Iqbal, Dushyant Singh Dahiya, Syeda Faiza Arif, Connor Campbell, Wade Lee-Smith, Mohammad Asif, Faisal Kamal, Aamir Saeed, Omar Horani

Division of Gastroenterology and Hepatology Faculty Papers

BACKGROUND: The use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) has remarkably increased in the past few years as they have demonstrated significant reduction in A1c and major cardiovascular outcomes and have led to weight loss with low risk of hypoglycemia. GLP-1 RA use has raised concerns about potential associations with increased gastric retention and adverse outcomes in upper endoscopy procedures.

METHODS: We conducted a comprehensive search across multiple databases to identify comparative studies evaluating the impact of GLP-1 RA exposure versus non-exposure on upper endoscopy outcomes. Studies comparing GLP-1 RAs to other medications were excluded. The primary outcome was …

In Re: Whittaker Clark & Daniels

2026 Decisions

USDC for the District of New Jersey

Ndls Communicator: Week Of 04.27.26, Notre Dame Law School

NDLS Communicator

The Latest News

• 3L Nikki Rafferty has been selected as the recipient of the 2026 Thomas L. Shaffer Public Interest Fellowship
• 3L Erin Hiestand has been named one of the American Constitution Society’s 2026 Next Generation Leaders
• Notre Dame Law School’s Barristers Mock Trial Team (the Law School’s Trial Advocacy Team) won the regional championship and advanced to nationals at the American Association for Justice (AAJ) Student Trial Advocacy Competition.
• The Notre Dame Exoneration Justice Clinic (EJC) will welcome three law students from the National Autonomous University of Mexico (UNAM) to its summer internship program.

Student News

• Roselis Díaz De …

A Rigorous And Ethical Methodological Framework For Navigating Cultural Differences With Police Officers In A South African Rural Community, Masefako Andronica Gumani

The Qualitative Report

Research contexts pose different challenges during research processes, and these challenges may affect the credibility of study findings. This was especially the case when, as a researcher, I interacted with police participants from different cultural backgrounds from my own. This paper reflects on my experience as a female Sepedi‑speaking researcher conducting a Ph.D. qualitative, grounded theory study with male and female South African Police Service (SAPS) officers from the Venda and Tsonga cultural backgrounds. I used a reflexive autoethnographic research design to purposively look at myself as the subject of inquiry and analyze my reflexive journal using reflexive thematic data …

Testimonios De Una Estudiante De Doctorado: Regaining Joy In Graduate School Through Research-Practice Partnerships, Sophia Piral Lee

The Qualitative Report

Through an epistolary critical autoethnography and Latina and Chicana feminist framework, I explore the question of how international graduate students of color can overcome cultural, linguistic, ethnoracial, and social class isolation on predominantly white campuses and in college towns. By writing a letter to my mother (one of my methods for survival in academia), I share my challenges as a Guatemalan, first-time mom, first-generation college student, international student, and non-English native speaker in graduate school during and after the COVID-19 pandemic. At the same time, this writing helps me recognize how I overcame my isolation and regained my joy and …

Healthcare Institutions’ Influences On Health Literacy Levels In Mothers In Greensboro, North Carolina, Wole Ajala

Walden Dissertations and Doctoral Studies

Immigrant populations experience persistent challenges within the U.S. healthcare system, including marginalization, discrimination, and limited access to understandable health information, which contribute to health disparities. Factors such as low income, cultural differences, and intersecting identities related to gender and race further compound these challenges. This qualitative phenomenological study examined how these social determinants of health influenced the health literacy experiences of African immigrant mothers in Greensboro, North Carolina. Data were collected through encrypted WhatsApp audio interviews with eight African immigrant mothers who had used healthcare services in the United States. Interview recordings were transcribed verbatim and analyzed using inductive thematic …

Strategies To Reduce Diagnostic Wait Times In Vha Facilities, Frankie Loadz Odlens Beaubrun

Walden Dissertations and Doctoral Studies

The Veterans Health Administration (VHA) is the largest integrated healthcare system in the United States, providing care to millions of veterans annually. Diagnostic service wait times affect veteran access to timely diagnoses and subsequent eligibility for disability benefits, vocational rehabilitation, and social services. The purpose of this integrative review was to identify evidence-based strategies to reduce diagnostic wait time within the VHA. The guiding review question addressed what strategies VA medical centers can use to reduce diagnostic wait times. Guided by Donabedian’s structure-process-outcome framework, a comprehensive literature search initially identified 487 sources across multiple databases. Subsequently, systematic screening and application …

Bound By Belief: Exploring The Influence Of Internalized Rape Myths On Survivor Agency And Identity, Arika I. White

Walden Dissertations and Doctoral Studies

This qualitative study explored how internalized RMA impacts survivors’ cognitive processing, coping strategies, and psychological agency, as observed by licensed psychotherapists who treat sexual assault survivors. Despite extensive literature on the societal impacts of RMA, less attention has been given to understanding how these cultural myths are internalized by survivors and manifest intrapsychically, influencing self-perception, self-blame, and identity reconstruction following trauma. Using a phenomenological approach, semi-structured interviews with therapists provided meta-level insights into how survivors’ narratives reflect internalized cultural stigma and misogynistic beliefs. Thematic analysis was used to identify patterns of maladaptive coping, internalized misogyny, and diminished agency, revealing how …

Fast Hyperspectral And Super-Resolved Mapping Of Lipid Membrane Polarity With Single-Molecule Sensitivity, Elric Dion Pott, Meek Yang, James Ethan Batey, Jole Embree, Bin Dong

Chemistry & Biochemistry Faculty Publications and Presentations

Cell membranes display nanoscale heterogeneity in lipid composition and organization that regulates vital biological processes yet remain challenging to resolve with conventional imaging. We introduce spectral phasor single-molecule localization microscopy (SP-SMLM), a hyperspectral and super-resolution method that combines wavefront-like optical filtering with single-molecule imaging for simultaneous spatial and spectral analysis. A lab-built three-channel imager with sine/cosine filters encodes emission spectra of single molecules into the phasor space, enabling high-throughput, high-SNR mapping of membrane polarity at sub-50 nm spatial and 15 s temporal resolutions. Through simulation, we validate that the phasor angle correlates with the spectral mean for single dye molecules. …