Digital Commons Network^™

Insights From The Histopathologic Analysis Of Acquired And Genetic Thoracic Aortic Aneurysms And Dissections, L Maximilian Buja, Bihong Zhao, Humaira Sadaf, Michelle Mcdonald, Ana M Segura, Li Li, Alana Cecchi, Siddharth K Prakash, Rana O Afifi, Charles C Miller, Anthony L Estrera, Dianna M Milewicz

Faculty, Staff and Student Publications

OBJECTIVE: The purpose of this study was to apply contemporary consensus criteria developed by the Society for Cardiovascular Pathology and the Association for European Cardiovascular Pathology to the evaluation of aortic pathology, with the expectation that the additional pathologic information may enhance the understanding and management of aortic diseases.

METHODS: A scoring system was applied to ascending aortic specimens from 42 patients with heritable thoracic aortic disease and known genetic variations and from 86 patients from a single year, including patients with known genetic variations (n = 12) and patients with sporadic disease (n = 74).

RESULTS: The various types …

Belzutifan, Hif-2Α Inhibitor, And Clear Cell Renal Cell Carcinoma With Somatic Von-Hippel-Lindau Loss-Of-Function Mutation, Kok Hoe Chan, Ningjing Li, Ran Lador, Mark Amsbaugh, Anneliese Gonzalez, Putao Cen

Faculty, Staff and Student Publications

The Von-Hippel-Lindau (VHL) gene, acting as a tumor suppressor, plays a crucial role in the tumorigenesis of clear cell renal cell carcinoma (ccRCC). Approximately 90% of individuals with advanced ccRCC exhibit somatic mutations in the VHL gene. Belzutifan, orally administered small-molecule inhibitor of hypoxia-induced factor-2α, has demonstrated promising efficacy in solid tumors associated with germline loss-of-function mutations in VHL, including ccRCC. However, its impact on cases with somatic or sporadic VHL mutations remains unclear. Here, we present 2 cases where belzutifan monotherapy was employed in patients with advanced ccRCC and somatic loss-of-function mutations in VHL. Both patients exhibited a swift …

Intouch Week Of February 12, 2024, New York Medical College

InTouch

• NYMC Celebrated the Grand Re-Opening of Doc’s Café
• NYMC and Regeneron Debut Neighborhood Science Seminar Series
• NYMC Alums Share Marriage, Memories, and a Lifetime Together
• LCME Element of the Week
• SIGN Hosts “Ask a Neurologist” Podcast Series
• Student Spotlight: SOM Student Ariel Yusupov Secures Spot in Westchester County Biosciences Accelerator Program

Probiotic Limosilactobacillus Reuteri Dsm 17938 Changes Foxp3 Deficiency-Induced Dyslipidemia And Chronic Hepatitis In Mice, Erini Nessim Kostandy, Ji Ho Suh, Xiangjun Tian, Beanna Okeugo, Erin Rubin, Sara Shirai, Meng Luo, Christopher M Taylor, Kang Ho Kim, J Marc Rhoads, Yuying Liu

Faculty, Staff and Student Publications

The probiotic Limosilactobacillus reuteri DSM 17938 produces anti-inflammatory effects in scurfy (SF) mice, a model characterized by immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (called IPEX syndrome in humans), caused by regulatory T cell (Treg) deficiency and is due to a Foxp3 gene mutation. Considering the pivotal role of lipids in autoimmune inflammatory processes, we investigated alterations in the relative abundance of lipid profiles in SF mice (± treatment with DSM 17938) compared to normal WT mice. We also examined the correlation between plasma lipids and gut microbiota and circulating inflammatory markers. We noted a significant upregulation of plasma lipids …

Efficacy Of Supplemental Ultrasound-Guided Pericapsular Nerve Group (Peng) Block Combined With Lateral Femoral Cutaneous Nerve Block In Patients Receiving Local Infiltration Analgesia After Hip Fracture Surgery: A Prospective Randomized Controlled Trial, Seung-Hee Yoo, Min-Jin Lee, Min-Hyouk Beak, Won-Joong Kim

Faculty, Staff and Student Publications

No abstract provided.

Heterogeneity In Maternal Mrnas Within Clutches Of Eggs In Response To Thermal Stress During The Embryonic Stage, Atsuko Sato, Yukie Mihirogi, Christine Wood, Yutaka Suzuki, Manuela Truebano, John Bishop

School of Biological and Marine Sciences

Background: The origin of variation is of central interest in evolutionary biology. Maternal mRNAs govern early embryogenesis in many animal species, and we investigated the possibility that heterogeneity in maternal mRNA provisioning of eggs can be modulated by environmental stimuli. Results: We employed two sibling species of the ascidian Ciona, called here types A and B, that are adapted to different temperature regimes and can be hybridized. Previous study showed that hybrids using type B eggs had higher susceptibility to thermal stress than hybrids using type A eggs. We conducted transcriptome analyses of multiple single eggs from crosses using eggs …

Black Youth Males Transitioning From The Juvenile Justice System To Comprehensive School, Andria R. Heaven

Graduate Student Dissertations, Theses, Capstones, and Portfolios

This dissertation explores the barriers faced by Black Youth Males Transitioning from the Juvenile Justice System to Comprehensive School.

The purpose of this study was to provide administrators with a product that can assist staff collaborating with Black male students to seamlessly and successfully transition to a comprehensive school after being released from a secured Department Juvenile Justice facility. The product addresses effective school support for Black male youths who have been detained in the juvenile justice system to re-engage them in such a way to achieve a diploma. This study also investigated school re-entry procedures with formerly incarcerated youth, …

Molecular-Guided Therapy For The Treatment Of Patients With Relapsed And Refractory Childhood Cancers: A Beat Childhood Cancer Research Consortium Trial., Giselle L Saulnier Sholler, Genevieve Bergendahl, Elizabeth C. Lewis, Jacqueline Kraveka, William Ferguson, Abhinav B. Nagulapally, Karl Dykema, Valerie I Brown, Michael S. Isakoff, Joseph Junewick, Deanna Mitchell, Jawhar Rawwas, William Roberts, Don Eslin, Javier Oesterheld, Randal K. Wada, Devang Pastakia, Virginia Harrod, Kevin Ginn, Raya Saab, Kevin Bielamowicz, Jason Glover, Eugenia Chang, Gina K. Hanna, Daniel Enriquez, Tyler Izatt, Rebecca F Halperin, Abigail Moore, Sara A. Byron, William P D Hendricks, Jeffrey M. Trent

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Children with relapsed central nervous system (CNS tumors), neuroblastoma, sarcomas, and other rare solid tumors face poor outcomes. This prospective clinical trial examined the feasibility of combining genomic and transcriptomic profiling of tumor samples with a molecular tumor board (MTB) approach to make real‑time treatment decisions for children with relapsed/refractory solid tumors.

METHODS: Subjects were divided into three strata: stratum 1-relapsed/refractory neuroblastoma; stratum 2-relapsed/refractory CNS tumors; and stratum 3-relapsed/refractory rare solid tumors. Tumor samples were sent for tumor/normal whole-exome (WES) and tumor whole-transcriptome (WTS) sequencing, and the genomic data were used in a multi-institutional MTB to make real‑time treatment …

Novice Kindergarten Through Second-Grade Teachers’ Perspectives Of Their Preparedness To Teach Students To Read, Shanell Lee-Angry

Walden Dissertations and Doctoral Studies

The majority of U.S fourth graders are not proficient in reading. With lawmakers in some U.S. states enacting “Read by Grade 3” laws, it is important for teachers to be well prepared to teach reading to their students. The purpose of this study was to explore novice kindergarten through second grade (K–2) teachers’ perspectives of their preparedness to teach students to read and their beliefs about what they needed to improve their strategies to teach reading. The conceptual framework was based on self-efficacy theory. The research questions addressed K–2 teachers’ perspectives on their preparedness to teach students to read and …

Making Customers More Loyal: The Role Of Value Cocreation In Branded Apps, Trang Phuc Tran, Adrienne Muldrow, Charlene Dadzie

AMTP Proceedings 2024

The paper develops a conceptual model that examines how value in use enhances value co-creation and then brand loyalty, and captures how value-in-use could change customer perception of branded app entertainment and perceived usefulness, leading to value co-creation. Data from 463 brand app users show that all hypothesized relationships are supported, except H5 (ENT -> COC). That means value co-creation is driven by value-in-use and perceived usefulness, but not by app entertainment. Moreover, value co-creation, in turn, has an impact on brand loyalty. Additionally, mediation effects exist in two paths: first, branded app entertainment and perceived usefulness mediate the effect …

Impact Of Ableist Microaggressions On Dis / Abled Youth: Perceptions Of School Climate And Academic Motivation, Nitza M. Torres Gonzalez

Theses and Dissertations

Ableist microaggressions are often subtle and covert negative attributions and behaviors towards people with dis/abilities that perpetuate stereotypes and inequities (Conover et al., 2021). Although limited research exists that has explored the impact of ableist microaggressions, some scholars have noted similar findings to studies to that have focused on racial microaggressions. Specifically, exposure to ableist microaggressions has been associated with negative mental health outcomes and increased negative affect, feelings of exclusion, and low academic performance and self-concept (Kattari, 2017; Kattari, 2020; Keller & Galgay, 2010; Lett et al., 2019; Nadal et al., 2014; Storey, 2007). Most of these findings have …

Interferon-Gamma Drives Brain Pathology In A Mouse Model Of Multiple System Atrophy, Public Relations

Browse All News

No abstract provided.

Children In The Workplace: An Exploration In Library Policy Making, Sharolyn Swenson, Marissa Anne Bischoff, Ryan Lee

Faculty Publications

Children in the workplace are becoming a more common discussion in various work environments, including libraries. Since the university has no policy addressing this issue, a task force was charged to draft a recommended policy for the university library regarding bringing children to the workplace. The task force reviewed existing policies and conducted a survey and interviews with library employees. The resulting policy provided guidelines for employees and their supervisors without being overly prescriptive. This article provides a case study of how the task force used assessment methods and tools to create an appropriate and inclusive policy. While the specific …

Correlation Enhanced Distribution Adaptation For Prediction Of Fall Risk, Ziqi Guo, Teresa Wu, Thurmon Lockhart, Rahul Soangra, Hyunsoo Yoon

Physical Therapy Faculty Articles and Research

With technological advancements in diagnostic imaging, smart sensing, and wearables, a multitude of heterogeneous sources or modalities are available to proactively monitor the health of the elderly. Due to the increasing risks of falls among older adults, an early diagnosis tool is crucial to prevent future falls. However, during the early stage of diagnosis, there is often limited or no labeled data (expert-confirmed diagnostic information) available in the target domain (new cohort) to determine the proper treatment for older adults. Instead, there are multiple related but non-identical domain data with labels from the existing cohort or different institutions. Integrating different …

United States National Science Foundation (Nsf) Scientific Integrity Policy

Copyright, Fair Use, Scholarly Communication, etc.

United States National Science Foundation (NSF) Scientific Integrity Policy

2024 Brain & Behavioral Health Poster, Faith Brandt

Brain & Behavioral Health Research Day

No abstract provided.

02/12/2024 Meeting, Varina A. Kosovich

Meeting Minutes

No abstract provided.

Variations In Duration Of Clinical Follow-Up After Spinal Fusion For Adolescent Idiopathic Scoliosis: A Survey Of Posna And Srs Membership, Taylor R Johnson, Nicole A Segovia, Xochitl Bryson, Meghan N Imrie, John S Vorhies

Faculty, Staff and Student Publications

Background: There are currently no evidence-based guidelines addressing the optimal duration of follow-up after posterior spinal fusion (PSF) for adolescent idiopathic scoliosis (AIS). Despite the safety and efficacy of PSF for AIS, long-term complications exist, including infection, pseudoarthrosis, adjacent segment disease, deformity progression, persistent pain, and junctional deformities. In this study, we describe practice variation existing among surgeons regarding duration and intervals of patient follow-up after surgical treatment of AIS in addition to factors influencing provider recommendations for duration of radiographic and clinical follow-up. This investigation of practice variation is important, as opportunities exist for both limiting unnecessary radiation exposure, …

Tumor- And Circulating-Free Dna Methylation Identifies Clinically Relevant Small Cell Lung Cancer Subtypes, Simon Heeke, Carl M Gay, Marcos R Estecio, Hai Tran, Benjamin B Morris, Bingnan Zhang, Ximing Tang, Maria Gabriela Raso, Pedro Rocha, Siqi Lai, Edurne Arriola, Paul Hofman, Veronique Hofman, Prasad Kopparapu, Christine M Lovly, Kyle Concannon, Luana Guimaraes De Sousa, Whitney Elisabeth Lewis, Kimie Kondo, Xin Hu, Azusa Tanimoto, Natalie I Vokes, Monique B Nilsson, Allison Stewart, Maarten Jansen, Ildikó Horváth, Mina Gaga, Vasileios Panagoulias, Yael Raviv, Danny Frumkin, Adam Wasserstrom, Aharona Shuali, Catherine A Schnabel, Yuanxin Xi, Lixia Diao, Qi Wang, Jianjun Zhang, Peter Van Loo, Jing Wang, Ignacio I Wistuba, Lauren A Byers, John V Heymach

Faculty, Staff and Student Publications

Small cell lung cancer (SCLC) is an aggressive malignancy composed of distinct transcriptional subtypes, but implementing subtyping in the clinic has remained challenging, particularly due to limited tissue availability. Given the known epigenetic regulation of critical SCLC transcriptional programs, we hypothesized that subtype-specific patterns of DNA methylation could be detected in tumor or blood from SCLC patients. Using genomic-wide reduced-representation bisulfite sequencing (RRBS) in two cohorts totaling 179 SCLC patients and using machine learning approaches, we report a highly accurate DNA methylation-based classifier (SCLC-DMC) that can distinguish SCLC subtypes. We further adjust the classifier for circulating-free DNA (cfDNA) to subtype …

Veggie Meat Alternatives: A Virtue-Ethical View, Carlo Alvaro

Publications and Research

This chapter discusses practical and ethical aspects concerning veggie meat alternatives. Upon consideration, it is argued that while the production, sale, and consumption of veggie meat alternatives seemingly contribute to a solution to environmental problems, we ought to consider veggie meat alternatives from a virtue-ethical perspective concerning human excellence and flourishing. Doing so reveals previously unexplored ethical reasons for not promoting the production, sale, and consumption of veggie meat alternatives. One reason in particular is that veggie meat alternatives stem from the lack of the virtue of temperance.

Probiotic Limosilactobacillus Reuteri Dsm 17938 Changes Foxp3 Deficiency-Induced Dyslipidemia And Chronic Hepatitis In Mice, Erini Nessim Kostandy, Ji Ho Suh, Xiangjun Tian, Beanna Okeugo, Erin Rubin, Sara Shirai, Meng Luo, Christopher M Taylor, Kang Ho Kim, J Marc Rhoads, Yuying Liu

Faculty, Staff and Student Publications

The probiotic Limosilactobacillus reuteri DSM 17938 produces anti-inflammatory effects in scurfy (SF) mice, a model characterized by immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (called IPEX syndrome in humans), caused by regulatory T cell (Treg) deficiency and is due to a Foxp3 gene mutation. Considering the pivotal role of lipids in autoimmune inflammatory processes, we investigated alterations in the relative abundance of lipid profiles in SF mice (± treatment with DSM 17938) compared to normal WT mice. We also examined the correlation between plasma lipids and gut microbiota and circulating inflammatory markers. We noted a significant upregulation of plasma lipids …

Examining The Feasibility And Acceptability Of An Online Mindfulness-Based Stress Reduction Program For Frontline Child Protection Social Workers In England, Oliver Beer, Lauren B. Mcinroy, Jennifer Hefner, Sandra Beer

School of Health Professions

This study explores the feasibility and acceptability of an online mindfulness-based intervention (O-MBI) for stress prevention and reduction among frontline child protection social workers (F-CPSWs) in England. In Phase I, a non-randomized, one-arm feasibility study (N=104) demonstrated post-O-MBI reductions in perceived stress and increased mindfulness. Phase II employed a phenomenological approach using semi-structured interviews (n=7). Participants suggested adjustments to content, delivery, and design, highlighting the need for customization. Despite promising results, the study underscores the importance of tailoring interventions to individual needs and circumstances. Future research should delve into O-MBI effectiveness with a more diverse F-CPSW sample.

Obit - Frank A. Fraembs, Journal-Gazette Times-Courier

EIU in the News

No abstract provided.

Impact Of Smoking And Drinking Habits On Lipid Profiles In Diabetic And Non-Diabetic Individuals & Their Oral Implications, Dinraj Kulkarni

Annual Research Symposium

The rising prevalence of lifestyle-related diseases, notably diabetes mellitus and cardiovascular diseases (CVD), underscores the importance of investigating modifiable risk factors such as smoking and alcohol consumption. These habits are known to influence lipid profiles, crucial indicators of cardiovascular health. Main aim of this study To investigate & evaluate the effect of smoking and drinking habits on lipid profiles of diabetic and non-diabetic individuals and their oral implications.

Rupture And Repair: Developing A Saggar-Fired Ceramic Approach To Building Trauma Resilience Through Making, Tending, Breaking And Mending, Jenny Bernstein Rangan

Expressive Therapies Capstone Theses

This capstone thesis charts the development of a method to make, tend, break, and mend a saggar-fired ceramic sculpture, addressing the question, “How can a ceramic process of rupture and repair be useful for developing resilience to trauma?” It highlights the value and drawbacks of the application of ceramics to art therapy. Current literature supports creative destruction as a healing tool for trauma survivors and details how to incorporate it safely. This four-day workshop involved two participants with a trauma history. Both had undergone years of therapy and were screened for ego strength. Results showed that the method can be …

Arid2 Mutations May Relay A Distinct Subset Of Cutaneous Melanoma Patients With Different Outcomes, Favour A Akinjiyan, George Nassief, Jordan Phillipps, Tolulope Adeyelu, Andrew Elliott, Farah Abdulla, Alice Y Zhou, George Souroullas, Kevin B Kim, Ari Vanderwalde, Soo J Park, George Ansstas

2020-Current year OA Pubs

ARID genes encode subunits of SWI/SNF chromatin remodeling complexes and are frequently mutated in human cancers. We investigated the correlation between ARID mutations, molecular features, and clinical outcomes in melanoma patients. Cutaneous melanoma samples (n = 1577) were analyzed by next-generation sequencing. Samples were stratified by pathogenic/likely pathogenic mutation in ARID genes (ARID1A/2/1B/5B). PD-L1 expression was assessed using IHC (SP142; positive (+): ≥ 1%). Tumor mutation burden (TMB)-high was defined as ≥ 10 mutations/Mb. Transcriptomic signatures predictive of response to immune checkpoint inhibitors-interferon gamma and T-cell inflamed score were calculated. Real-world overall survival (OS) information was obtained from insurance claims …

The Daily Gamecock: February 2024, University Of South Carolina, Office Of Student Media

February

No abstract provided.

Assessment Of Social Vulnerability Impact In Care And Prognosis Of Sinonasal Cancers In The United States, Achilles A. Kanaris, David J. Fei-Zhang, Lily B. Fletcher, Stephanie S. Smith, Urjeet A. Patel, Jill N. D'Souza, Daniel C. Chelius, Anthony M. Sheyn, Jeffrey C. Rastatter

School of Medicine Faculty Publications

Key Points: Social determinants of health interactively influence sinonasal cancer care and prognosis. Housing-transportation and socioeconomic status showed the largest associations with disparities. The social vulnerability index can reveal the social determinants of sinonasal cancers.

The Impact Of Social Exclusion On Anticipatory Attentional Processing, John E. Kiat, Jacob E. Cheadle, Bridget J. Goosby

Department of Sociology: Faculty Publications

The importance of understanding how we anticipate and prepare for social rejection is underscored by the mental and physical toll of continual social vigilance. In this study, we investigate the impact of social rejection on anticipatory attentional processes using the well-known Cyberball task, a paradigm in which participants engage in a game of catch with virtual avatars who after an initial period of fair-play (inclusion condition) then exclude the participant from the game (exclusion condition). The degree of anticipatory attention allocated by subjects towards the avatars was assessed by measuring P3b responses towards the avatars’ preparatory actions (i.e. the phase …

Indicators Of Community Physical Activity Resources And Opportunities And Variation By Community Sociodemographic Characteristics: A Scoping Review, Ann E. Rogers, Michaela A. Schenkelberg, Peter Stoepker, Danielle Westmark, Deepa Srivastava, David A. Dzewaltowski

Department of Child, Youth, and Family Studies: Faculty Publications

Objective: This scoping review synthesizes studies examining community-level variability in physical activity resource (assets) and opportunity (organized group physical activity services) availability by community sociodemographic characteristics to describe methodologies for measuring resources/opportunities, indicators characterizing availability, and associations between community-level sociodemographic characteristics and availability.

Methods: A systematic search was conducted in MEDLINE, CINAHL, PsycINFO, and Scopus for literature through 2022. Eligible studies quantitatively examined measures of physical activity resource/opportunity availability by community-level racial, ethnic, and/or socioeconomic characteristics within geospatially defined communities. Extracted data included: community geospatial definitions, sociodemographic characteristics assessed, methodologies for measuring and indicators of community physical activity …