Digital Commons Network^™

Studying Fisher Mortality In The Granite State, Robbin Ray

UNH Today Archive

No abstract provided.

New Phase Of Community Partnership Program Focuses On Oxford, Erin Garrett

University of Mississippi News

OXFORD, Miss. – The University of Mississippi is partnering with the city of Oxford on a new phase of the M Partner program that aims to align university resources with city priorities to improve quality of life for all residents.

2024 February 12, Faculty Senate Minutes, State Univerity Of New York College At Cortland

Minutes

Faculty Senate Minutes, 2024 February 12

SUNY Cortland Faculty Senate Committees Roster 2024-2025

Physio-Chemical Modifications To Re-Engineer Small Extracellular Vesicles For Targeted Anticancer Therapeutics Delivery And Imaging, Rahmat Asfiya, Lei Xu, Anjugam Paramanantham, Kuanysh Kabytaev, Anna Chernatynskaya, Grace Mccully, Hu Yang, Akhil Srivastava

Chemical and Biochemical Engineering Faculty Research & Creative Works

Cancer theranostics developed through nanoengineering applications are essential for targeted oncologic interventions in the new era of personalized and precision medicine. Recently, small extracellular vesicles (sEVs) have emerged as an attractive nanoengineering platform for tumor-directed anticancer therapeutic delivery and imaging of malignant tumors. These natural nanoparticles have multiple advantages over synthetic nanoparticle-based delivery systems, such as intrinsic targeting ability, less immunogenicity, and a prolonged circulation time. Since the inception of sEVs as a viable replacement for liposomes (synthetic nanoparticles) as a drug delivery vehicle, many studies have attempted to further the therapeutic efficacy of sEVs. This article discusses engineering strategies …

“To Be Straight Or Closeted:” Lesbian, Gay, And Bisexual College Women In Greek Life In The Context Of The Lgb Experience In The United States, Olivia Morreale

Sociology Between the Gaps: Forgotten and Neglected Topics

No abstract provided.

Board Of Directors Meeting Minutes (February 12, 2024), Dmacc

Board of Directors Meeting Minutes

This file contains the minutes from the Des Moines Area Community College Board meeting held on February 12, 2024.

The Role Of Muslim Women In Nigeria’S Socioeconomic Development Through The Implementation Of The United Nations Sustainable Development Goals, Faqiat Afolake Adeaga

USF Tampa Graduate Theses and Dissertations

This research explores the often underestimated yet pivotal role of Muslim women in propelling socio-economic development in Nigeria, specifically focusing on the implementation of the United Nations Sustainable Development Goals (SDGs). The primary research question seeks to comprehend the transformative impact of faith-based women-led NGOs, including Ansar-ud- Deen, Nawair-ud-Deen, FOMWAN, and NASFAT, on Muslim women's empowerment and their contribution to SDG1 (extreme poverty), SDG3 (health), SDG4 (education), and SDG5 (gender equality) in Nigeria. Simultaneously, the secondary research question explores successful strategies employed by these organizations in empowering Muslim women, with a keen focus on potential areas for improvement. Incorporating research …

Flow Cytometry Of Dnmt1 As A Biomarker Of Hypomethylating Therapies, Philip G. Woost, Basem M. William, Brenda W. Cooper, Masumi Ueda Oshima, Folashade Otegbeye, Marcos J. De Lima, David Wald, Reda Z. Mahfouz, Yogen Saunthararajah, Tammy Stefan, James W. Jacobberger

Faculty Scholarship

The 5-azacytidine (AZA) and decitabine (DEC) are noncytotoxic, differentiation-inducing therapies approved for treatment of myelodysplastic syndrome, acute myeloid leukemias (AML), and under evaluation as maintenance therapy for AML postallogeneic hematopoietic stem cell transplant and to treat hemoglobinapathies. Malignant cell cytoreduction is thought to occur by S-phase specific depletion of the key epigenetic regulator, DNA methyltransferase 1 (DNMT1) that, in the case of cancers, thereby releases terminal-differentiation programs. DNMT1-targeting can also elevate expression of immune function genes (HLA-DR, MICA, MICB) to stimulate graft versus leukemia effects. In vivo, there is a large inter-individual variability in DEC and 5-AZA activity because of …

The Lived Experience Of Nursing Faculty At Rural Community Colleges In East Texas During The Covid-19 Pandemic, Mary N. Isichei

Walden Dissertations and Doctoral Studies

The COVID-19 pandemic highlighted the need for public health (PH) emergency preparedness and for the formal training of frontline workers, primarily nurses, on how to manage PH emergencies. The need for the latter was especially evident at U.S. rural community colleges (RCC), a subset of institutions of higher education (IHEs), which, due to a lack of resources, lacked PH-trained nursing faculty members (NFMs). The purpose of this qualitative study was to discover the lived experience of NFMs in RCC in East Texas during the COVID-19 pandemic. The phenomenological theoretical (PT) framework assisted in understanding the lived experience of the NFMs …

Ohio University Faculty Senate Minutes February 12, 2024, Angela Brock

Faculty Senate Minutes

No abstract provided.

Unh Student Interns Critical Voice, Support To Advance Unh's Sustainability Efforts, Sustainability Institute

Sustainability Institute Blog

No abstract provided.

Examining The Evolution Of Network Governance Forms Of An Event Leveraging Collective: A Longitudinal Investigation, Landy Lu, Ran Zhou, Guangzhou Chen, Laura Misener

Faculty Publications

This study aims to investigate how an event leveraging collective’s network governance forms evolved from pre- to post‐Games and how these forms influenced members' collaborative engagement. We adopted a longitudinal qualitative case study approach. Our primary data sources included 996 pages of archival documents and 18 interviews with collective members. We found that in the pre- and during-Games stage, the leveraging collective adopted a shared participant-governed form with a facilitator. This participant-driven structure could enhance connectedness and collaborative engagement among member organizations. In the postevent phase, the collective assumed a pillar-governed form with a facilitator. Although this structure appeared to …

Hymenopteran Parasitoid Complex And Fall Armyworm: A Case Study In Eastern India, Subhajit Pal, Swarnali Bhattacharya, Tapamay Dhar, Ankita Gupta, Arunava Ghosh, Sandip Debnath, Nikhitha Gangavarapu, Prajna Pati, Nilanjana Chaudhuri, Hirak Chatterjee, Sabita Kumar Senapati, Prateek Madhab Bhattacharya, Mahesh Kumar Gathala, Alison M. Laing

Department of Entomology: Faculty Publications

Fall armyworm (FAW), Spodoptera frugiperda (J.E. Smith) has significantly affected maize crop yields, production efficiency, and farmers’ incomes in the Indian Eastern Gangetic Plains region since it was first observed in India in 2018. A lack of awareness by maize growers of the appropriate selection, method, and timing of insecticide application not only creates a barrier to sustainable FAW control but also contributes to increased environmental pollution, reduced human health and increased production costs. We demonstrated that FAW inflicted the most damage in early whorl growth stage of maize, regardless of whether chemical insecticides were applied. FAW egg masses and …

Understanding The Role Of Palliative Care Within Routine Care Of Advanced Liver Disease, Simone A. Jarrett, Edward Bley, Richard S. Kalman

Einstein Health Papers

Purpose of Review

This paper aims to investigate the crucial role of palliative care in the management of chronic liver disease (CLD) and cirrhosis. Faced with a global surge in liver-related morbidity and mortality, our goal is to understand the impact of early engagement with palliative care specialists on symptom management, quality of life, and the overall trajectory of advanced liver disease.

Recent Findings

While strides have been made in preventing and treating specific etiologies of CLD, such as viral infections, the escalating rates of alcohol use and obesity present new challenges for physicians. Despite advancements, liver transplantation unfortunately remains …

Charting Early Trajectories Of Executive Control With The Shape School, Caron A. C. Clark, Tiffany D. Sheffield, Nicolas Chevalier, Jennifer Mize Nelson, Sandra A. Wiebe, Kimberly Andrews Espy

Department of Psychology: Faculty Publications

Despite acknowledgement of the importance of executive control for learning and behavior, there is a dearth of research charting its developmental trajectory as it unfolds against the background of children’s sociofamilial milieus. Using a prospective, cohort-sequential design, this study describes growth trajectories for inhibitory control and cognitive flexibility across the preschool period in relation to child sex and sociofamilial resources. At ages 3, 3.75, 4.5, and 5.25 years, children (N = 388) from a broad range of social backgrounds were assessed using the Shape School, a graduated measure of executive control incorporating baseline, inhibitory control, and cognitive flexibility conditions. …

Probiotic Limosilactobacillus Reuteri Dsm 17938 Changes Foxp3 Deficiency-Induced Dyslipidemia And Chronic Hepatitis In Mice, Erini Nessim Kostandy, Ji Ho Suh, Xiangjun Tian, Beanna Okeugo, Erin Rubin, Sara Shirai, Meng Luo, Christopher M. Taylor, Kang Ho Kim, J. Marc Rhoads, Yuying Liu

School of Medicine Faculty Publications

The probiotic Limosilactobacillus reuteri DSM 17938 produces anti-inflammatory effects in scurfy (SF) mice, a model characterized by immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (called IPEX syndrome in humans), caused by regulatory T cell (Treg) deficiency and is due to a Foxp3 gene mutation. Considering the pivotal role of lipids in autoimmune inflammatory processes, we investigated alterations in the relative abundance of lipid profiles in SF mice (± treatment with DSM 17938) compared to normal WT mice. We also examined the correlation between plasma lipids and gut microbiota and circulating inflammatory markers. We noted a significant upregulation of plasma lipids …

Chimes: February 12, 2024, Calvin University

Chimes

"Our strategy is enrollment growth" Calvin's updated Vision 2030 plan reflects institutional optimism by Savannah Shustack

Spectator turnout for athletic games climbs by Lauren Nyong

Calvin student's home-brewed app achieves success after success by Jacob Westra

Honors program seeks renewed emphasis on interdisciplinarity by Maya Oeverman

Calvin athletics hosts multiple sporting events throughout siblings' weekend by Dillion Baumchen

Calvin's homemade dune continues to provide research opportunities by Ethan Meyers

Faculty orientation seminar celebrates thirty years anniversary by Nolan Cowan

OCD representation on screen should encompass all facets of the mental illness by Liana Hirner

Liptzin, Benjamin "Ben", Lydia Wampold

Bronx Jewish History Project

Ben Liptzin grew up in the Bronx on 168th Street between the Grand Concourse and Sheridan Avenue in a four-room apartment above a laundromat. His parents were Polish Jewish immigrants, and his father worked as a presser in the garment industry. Liptzin attended a yeshiva until 5th grade, after which he entered the public school system. He later attended the Bronx High School of Science, Columbia University, and medical school in Rochester. Liptzin became a geriatric psychiatrist and taught at institutions including the University of Massachusetts and Mount Sinai. He later served as Chair of Psychiatry at Baystate Medical Center …

Improving Nurse's Documentation In The Emergency Department, Jacqueline N. Wright-Cole

Dissertations

The appropriate documentation and effective hand-off communications are essential components for attaining and maintaining the continuity of quality care for patients in the emergency department. Despite global efforts and standards geared towards improving the accuracy and function of documentation, the issue of incomplete documentation and hand-off communication persist in the local emergency department. Incomplete documentation and handoff communications have been regarded as key factors of delayed patient care as well as discontinuation of care in the clinical setting. A detailed study conducted for evaluating the effectiveness and benefits of the Institute Healthcare Improvement SBAR guideline as a checklist on nurses' …

Educators’ Perspectives Of How To Support Mathematics Achievement Of Grade 3 Through Grade 5 At-Risk Students, Shanerron Fordham-Knox

Walden Dissertations and Doctoral Studies

The problem addressed in this study was that teachers are struggling to support the instructional needs of at-risk students Grades 3–5 in mathematics in a Southern state. The purpose of this basic qualitative study was to explore the perspectives of Grades 3–5 teachers of the instructional supports, approaches, and recommendations to support the mathematics achievement of at-risk students in Grades 3–5. Bruner’s theory on the stages of representation informed this study. The research questions focused on Elementary teachers' perspectives and recommendations of instructional supports and approaches to support the mathematics achievement of at-risk students in Grades 3–5. Data were collected …

The Free Press Vol. 55, Issue 7, 02-12-2024, Dakota Eddy

Free Press, The

Campus Police Announces New Body Camera Technology--USM Extends Priority Deadline to Apply for Financial Aid--Huskies Distraught over Parking Ticket Debacle--"An Extraordinary Place"--Games and Activities--E=Sports Team Gains New Arena

The Effectiveness Of Counseling Juveniles And Guardians As A Measure Of Recidivism, Robert D. Johnson

Walden Dissertations and Doctoral Studies

This study explored the lived experiences and perceptions of 10 juvenile justice professionals who had interacted with juvenile offenders and their guardians. This phenomenological qualitative study aimed to examine the outcomes of functional family therapy (FFT) between juvenile offenders and their guardians and their impact on recidivism rates in the National Capital Region portion of the Washington Metropolitan area. The theoretical framework that guided this study was FFT, which focuses on family dynamics and interactions while addressing a youth’s problem behavior. During semi-structured interviews (conducted via Zoom (due to COVID-19 restrictions), participants were asked open-ended questions about their feelings, experiences, …

African American Family Structure Of Caring For A Member With Alzheimer's Disease And Dementia, Sherry Lane Perry

Walden Dissertations and Doctoral Studies

Alzheimer’s disease and related dementia (ADRD) affect African Americans (AA) more than other ethnic or racial groups. It is common for AA diagnosed with ADRD to be cared for in the home. Historically, family members that provide care consist of significant others, relatives, and extended family. The United States Census Bureau showed an increase in Americans aged sixty and older from 55.7 million to 74.6 million. Due to the increase in the AA elderly population, the need for family caregivers will increase for this minority group. This study explored how AA family caregivers described their experiences and unique family structure …

Residential Metals Abatement Program Construction Completion Report (Non-Residential Parcels – Indoor Soil) - Butte High School, Environmental Resource Management (Erm)

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Phase I Study Of Mtorc1/2 Inhibitor Sapanisertib (Cb-228/Tak-228) In Combination With Metformin In Patients With Mtor/Akt/Pi3k Pathway Alterations And Advanced Solid Malignancies, Vivek Subbiah, Niamh Coleman, Sarina A Piha-Paul, Apostolia M Tsimberidou, Filip Janku, Jordi Rodon, Shubham Pant, Ecaterina E Ileana Dumbrava, Siqing Fu, David S Hong, Shizhen Zhang, Ming Sun, Yunfang Jiang, Jason Roszik, Juhee Song, Ying Yuan, Funda Meric-Bernstam, Aung Naing

Faculty, Staff and Student Publications

BACKGROUND: Sapanisertib (CB-228/TAK-228) is a potent, selective ATP-competitive, dual inhibitor of mTORC1/2. Metformin is thought to inhibit the mTOR pathway through upstream activation of 5'-AMP-activated protein kinase (AMPK) suggesting combination therapy may enhance antitumor activity of sapanisertib. We report preliminary safety, tolerability, and efficacy from the dose-escalation study of sapanisertib in combination with metformin in patients with advanced solid tumors.

METHODS: Patients with advanced metastatic solid tumors resistant or refractory to standard treatment, with and without mTOR/AKT/PI3K pathway alterations, received sapanisertib 3 or 4 mg daily together with metformin once to three times daily (500-1,500 mg). All patients underwent 14-day …

Online Bilingual Co-Design: Developing Resources With People With Disability And Family Members From Refugee Backgrounds, Angela Dew, Mahmoud Murad, Louisa Smith, Joanne Watson, Kim Robinson, Maree Higgins, Cathy Preston-Thomas, Mardi Stow, Ingrid Culos, Mariano Coello, Shakeh Momartin, Christian Astourian, Kelley Johnson, Caroline Lenette, Katherine Boydell

The Qualitative Report

People with disability from Syrian and Iraqi refugee backgrounds living in Australia have limited access to information and resources in Arabic language. Our study aim was to use a co-design process to create a suite of Arabic-language resources to increase information access and build capacity of people with disability and family members from refugee backgrounds to use services, and of disability and refugee services to provide relevant support. Following a rapid literature review about access to supports and services for people with disability from refugee backgrounds, workshops were held with 38 people with disability and family members from Syrian and …

Insights From The Histopathologic Analysis Of Acquired And Genetic Thoracic Aortic Aneurysms And Dissections, L Maximilian Buja, Bihong Zhao, Humaira Sadaf, Michelle Mcdonald, Ana M Segura, Li Li, Alana Cecchi, Siddharth K Prakash, Rana O Afifi, Charles C Miller, Anthony L Estrera, Dianna M Milewicz

Faculty, Staff and Student Publications

OBJECTIVE: The purpose of this study was to apply contemporary consensus criteria developed by the Society for Cardiovascular Pathology and the Association for European Cardiovascular Pathology to the evaluation of aortic pathology, with the expectation that the additional pathologic information may enhance the understanding and management of aortic diseases.

METHODS: A scoring system was applied to ascending aortic specimens from 42 patients with heritable thoracic aortic disease and known genetic variations and from 86 patients from a single year, including patients with known genetic variations (n = 12) and patients with sporadic disease (n = 74).

RESULTS: The various types …

Belzutifan, Hif-2Α Inhibitor, And Clear Cell Renal Cell Carcinoma With Somatic Von-Hippel-Lindau Loss-Of-Function Mutation, Kok Hoe Chan, Ningjing Li, Ran Lador, Mark Amsbaugh, Anneliese Gonzalez, Putao Cen

Faculty, Staff and Student Publications

The Von-Hippel-Lindau (VHL) gene, acting as a tumor suppressor, plays a crucial role in the tumorigenesis of clear cell renal cell carcinoma (ccRCC). Approximately 90% of individuals with advanced ccRCC exhibit somatic mutations in the VHL gene. Belzutifan, orally administered small-molecule inhibitor of hypoxia-induced factor-2α, has demonstrated promising efficacy in solid tumors associated with germline loss-of-function mutations in VHL, including ccRCC. However, its impact on cases with somatic or sporadic VHL mutations remains unclear. Here, we present 2 cases where belzutifan monotherapy was employed in patients with advanced ccRCC and somatic loss-of-function mutations in VHL. Both patients exhibited a swift …

Intouch Week Of February 12, 2024, New York Medical College

InTouch

• NYMC Celebrated the Grand Re-Opening of Doc’s Café
• NYMC and Regeneron Debut Neighborhood Science Seminar Series
• NYMC Alums Share Marriage, Memories, and a Lifetime Together
• LCME Element of the Week
• SIGN Hosts “Ask a Neurologist” Podcast Series
• Student Spotlight: SOM Student Ariel Yusupov Secures Spot in Westchester County Biosciences Accelerator Program

Probiotic Limosilactobacillus Reuteri Dsm 17938 Changes Foxp3 Deficiency-Induced Dyslipidemia And Chronic Hepatitis In Mice, Erini Nessim Kostandy, Ji Ho Suh, Xiangjun Tian, Beanna Okeugo, Erin Rubin, Sara Shirai, Meng Luo, Christopher M Taylor, Kang Ho Kim, J Marc Rhoads, Yuying Liu

Faculty, Staff and Student Publications

The probiotic Limosilactobacillus reuteri DSM 17938 produces anti-inflammatory effects in scurfy (SF) mice, a model characterized by immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (called IPEX syndrome in humans), caused by regulatory T cell (Treg) deficiency and is due to a Foxp3 gene mutation. Considering the pivotal role of lipids in autoimmune inflammatory processes, we investigated alterations in the relative abundance of lipid profiles in SF mice (± treatment with DSM 17938) compared to normal WT mice. We also examined the correlation between plasma lipids and gut microbiota and circulating inflammatory markers. We noted a significant upregulation of plasma lipids …