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Thermal Runaway Analysis And Cooling Strategies For Nmc 523 Li-Ion Battery Packs Using Pcm, Heat Pipes, And Air Cooling, Vijethvardhan Singh

Master's Theses

The growing demand for electric vehicles (EVs) necessitates efficient thermal management of lithium-ion batteries (LIBs), especially NMC 523 cells. This thesis investigates thermal runaway (TR) mechanisms and evaluates cooling strategies to mitigate overheating risks. Using ANSYS Fluent, the TR of four cells in series was simulated and validated with Jun Wu et al.'s experimental data, achieving an error margin below 10%. Peak temperatures reached 1,126°C in the first cell, with delayed propagation in adjacent cells. Sensitivity analysis of voltage, current, and state of charge (SOC) under varying C-rates was performed using a multi-scale multi-domain (MSMD) battery model. A logarithmic voltage …

Extracellular Carriers Control Lipid-Dependent Secretion, Delivery, And Activity Of Wnt Morphogens, Taciani De Almeida Magalhaes, Jingjing Liu, Charlene Chan, Kleiton Silva Borges, Jiuchun Zhang, Andrew J Kane, Bradley M Wierbowski, Yunhui Ge, Zhiwen Liu, Prabhath Mannam, Daniel Zeve, Ron Weiss, David T Breault, Pengxiang Huang, Adrian Salic

Faculty, Staff and Students Publications

WNT morphogens trigger signaling pathways fundamental for embryogenesis, regeneration, and cancer. WNTs are modified with palmitoleate, which is critical for binding Frizzled (FZD) receptors and activating signaling. However, it is unknown how WNTs are released and spread from cells, given their strong lipid-dependent membrane attachment. We demonstrate that secreted FZD-related proteins and WNT inhibitory factor 1 are WNT carriers, potently releasing lipidated WNTs and forming active soluble complexes. WNT release occurs by direct handoff from the membrane protein WNTLESS to the carriers. In turn, carriers donate WNTs to glypicans and FZDs involved in WNT reception and to the NOTUM hydrolase, …

Crispr-Dipoff: An Interpretable Deep Learning Approach For Crispr Cas-9 Off-Target Prediction, Md Toufikuzzaman, Md Abul Hassan Samee, M Sohel Rahman

Faculty, Staff and Students Publications

CRISPR Cas-9 is a groundbreaking genome-editing tool that harnesses bacterial defense systems to alter DNA sequences accurately. This innovative technology holds vast promise in multiple domains like biotechnology, agriculture and medicine. However, such power does not come without its own peril, and one such issue is the potential for unintended modifications (Off-Target), which highlights the need for accurate prediction and mitigation strategies. Though previous studies have demonstrated improvement in Off-Target prediction capability with the application of deep learning, they often struggle with the precision-recall trade-off, limiting their effectiveness and do not provide proper interpretation of the complex decision-making process of …

Sigma Leverages Protein Structural Information To Predict The Pathogenicity Of Missense Variants, Hengqiang Zhao, Huakang Du, Sen Zhao, Zefu Chen, Yaqi Li, Kexin Xu, Bowen Liu, Xi Cheng, Wen Wen, Guozhuang Li, Guilin Chen, Zhengye Zhao, Guixing Qiu, Deciphering Disorders Involving Scoliosis & Comorbidities (Disco) Study, Pengfei Liu, Terry Jianguo Zhang, Zhihong Wu, Nan Wu

Faculty, Staff and Students Publications

Leveraging protein structural information to evaluate pathogenicity has been hindered by the scarcity of experimentally determined 3D protein. With the aid of AlphaFold2 predictions, we developed the structure-informed genetic missense mutation assessor (SIGMA) to predict missense variant pathogenicity. In comparison with existing predictors across labeled variant datasets and experimental datasets, SIGMA demonstrates superior performance in predicting missense variant pathogenicity (AUC = 0.933). We found that the relative solvent accessibility of the mutated residue contributed greatly to the predictive ability of SIGMA. We further explored combining SIGMA with other top-tier predictors to create SIGMA+, proving highly effective for variant pathogenicity prediction …

Incubating Education: The Lived Experiences Of Louisiana Elementary And Middle School Teachers When Piloting A 4-H Stem School Enrichment Curriculum, Crystal Rose Ahrens

LSU Doctoral Dissertations

This study addressed a deficiency in the agricultural literacy of the U.S. population by focusing on the challenges that core subject teachers face when integrating agriculture into their curriculum. Using a phenomenological research approach, this investigation explored the lived experiences of Louisiana teachers who piloted a 4-H STEM curriculum, focusing on the growth in agricultural literacy of the teachers while instructing third and eighth-grade students on the agricultural-based and STEM-focused topic of embryology. Employing a transcendental phenomenological approach, I acknowledged my biases through reflexivity and adhered to ethical considerations, including informed consent and confidentiality. Key findings emerged through four themes …

Death, Dreaming, And Diaspora: Achieving Orientation Through Afro-Spirituality, Liz Johnston, Jaime Elizabeth Johnston

LSU Doctoral Dissertations

Enslavement, colonization, and the systems that uphold racial injustice were and still are a series of new, unfathomable, and challenging experiences that prompt individuals within the diaspora to seek orientation. How does a human cope with centuries of attempts at the systematic destruction of their humanity, culture, and identity? How can they reclaim that identity, especially when so much of it seems lost? I address these questions by utilizing texts from the expansive body of work regarding ethnographic-historical-religious studies on Afro-spiritual practices to better analyze instances in literature in the ongoing practice of diasporic orientation. In this project, I argue …

Self-Renewing Human Naïve Pluripotent Stem Cells Dedifferentiate In 3d Culture And Form Blastoids Spontaneously, Mingyue Guo, Jinyi Wu, Chuanxin Chen, Xinggu Wang, An Gong, Wei Guan, Rowan M Karvas, Kexin Wang, Mingwei Min, Yixuan Wang, Thorold W Theunissen, Shaorong Gao, José C R Silva

2020-Current year OA Pubs

Human naïve pluripotent stem cells (hnPSCs) can generate integrated models of blastocysts termed blastoids upon switch to inductive medium. However, the underlying mechanisms remain obscure. Here we report that self-renewing hnPSCs spontaneously and efficiently give rise to blastoids upon three dimensional (3D) suspension culture. The spontaneous blastoids mimic early stage human blastocysts in terms of structure, size, and transcriptome characteristics and are capable of progressing to post-implantation stages. This property is conferred by the glycogen synthase kinase-3 (GSK3) signalling inhibitor IM-12 present in 5iLAF self-renewing medium. IM-12 upregulates oxidative phosphorylation-associated genes that underly the capacity of hnPSCs to generate blastoids …

Catastrophe Of War, Sujit Kumar Singh, Ayushi Jaiswal

Critical Humanities

The paper selects the novel Palpasa Café (2005) by Nepali author Narayan Wagle to highlight the factors that contributed to the Maoist insurgency and counter-insurgency that punctured the Nepali consciousness. It will also critique Eurocentric trauma theory for diminishing the South Asian perspectives of trauma (incidents) from the main discourse of trauma theory. In addition, the paper will explore the detrimental impacts of war and conflict as experienced by Nepalese cops and civilians together, and its long-lasting imprint on their psyche as manifested in different forms of trauma in the text. The dissemination of the 'inarticulable trauma' concept into something …

An Affirmation Of Coexistence Between Artificial Intelligence (Ai) And Human Intelligence (Hi): An Inquiry Into The Structure Of Kazuo Ishiguro’S Novel, Klara And The Sun, Shiva Hari Mainaly

Critical Humanities

A narrative reflective of the perils and promises of automation entering the subjective realm of humankind, Kazuo Ishiguro’s latest novel, Klara and the Sun, confronts us with the notion of coexistence between artificial intelligence (AF) and human intelligence (HF) by uncovering a robust structure arising from the contestation amidst a host of binaries: Human versus machine, AI versus HI, self versus the other, science versus nature, and the list goes on. Although a vast majority of analytical inquiries into this novel uncover the incoherence of human identity and consciousness in the society deeply invested in affordances of the fifth industrial …

“This Wonderful Machine”: How Should We Teach Humanities Texts Like Gulliver’S Travels In The Time Of Chatgpt?, Richard J. Haslam

Critical Humanities

The quoted phrase in the essay title comes from a passage in Jonathan Swift's Gulliver’s Travels in which a Grand Academy of Lagado professor demonstrates a “wonderful Machine” that can generate scores of books “without the least Assistance from Genius or Study.” The essay explore the challenge for teaching classic humanities texts like Gulliver that the (perhaps not so) “wonderful Machine” called ChatGPT poses. Student Owen Terry’s Chronicle essay (May 12, 2023) identifies two crucial aspects of that challenge: “We don’t fully lean into AI and teach how to best use it, and we don’t fully prohibit it to keep …

From Polygraphs To Truth Machines: Artificial Intelligence In Lie Detection, Jo Ann Oravec

Critical Humanities

The proliferation of artificial intelligence (AI)-enhanced lie detection tools in business, educational, community, and governmental contexts signals a new era of deception detection. With these AI developments, collections of intimate biometric information such as facial and retinal data, keystroke patterns, brain scans, and physiological changes in the cardiovascular system are combined with personal profiles to produce analyses of a subject’s supposed veracity. This article explores some early lie detection technologies (such as the polygraph) and discusses the influences that lie detection initiatives have had in human interactions through the decades. It addresses the empirical issues of whether specific AI technologies …

Thriving In College: International, First-Generation, And Transfer Students, Hannah Webb, Nikita Kulkarni, Dustin Grabsch

SMU Journal of Undergraduate Research

Underrepresented-student groups experience unique challenges throughout their college experience, the impacts of which can be assessed by measuring students’ levels of thriving. The purpose of this study was to understand the thriving of underrepresented college students—first-generation, international, and transfer students, specifically. To understand this, we sought to measure students’ thriving levels and determine the experiences contributing to or detracting from their perception of thriving. This study utilized a sequential exploratory design using the established 72-item thriving quotient survey to measure students’ overall thriving levels. In addition, the study utilized a qualitative content analysis on an open-ended question asking participants to …

Identifying Barriers To Mental Health Services Utilization For Black Youth In The United States: A Qualitative Study, Emily Stein, Matthew Hutnyan, Neely Myers

SMU Journal of Undergraduate Research

Mental health in Black communities and racial/ethnic disparities in mental health service utilization remain growing concerns. Evidence suggests that psychotic disorders may be more prevalent among Black individuals than white individuals and the Black community faces barriers to care that can negatively influence outcomes. To better understand these barriers, we interviewed mental healthcare providers (n = 11) and Black young adults with first-person experience of psychosis (n = 13) about the experiences of minority young adults with mental health treatment. We analyzed interview transcripts and, consistent with constructivist grounded theory methods, identified iterative patterns across individuals about barriers to care. …

Cognitive Reappraisal Is Associated With Lower Dysphoria Symptoms During The Covid-19 Pandemic, Nadia Armstrong, Diane Moon, Holly Bowen

SMU Journal of Undergraduate Research

The COVID-19 pandemic has created unprecedented mental health concerns generally, but particularly for young adults navigating an already fluctuating and uncertain period of their lives. While there are many factors related to mental health, it is well-documented that emotion regulation– the ability to modulate an emotion or set of emotions– and risk perception appear to be relevant to the development, maintenance, and treatment of psychopathology. The current study aimed to assess the relationship between emotion regulation processes, COVID-19 risk perception, and dysphoria symptoms during the early months of the pandemic. Between April - May 2020, 243 undergraduate participants completed the …

Radon Plate-Out And The Effects Of Airflow And Electric Charge For Dark Matter Experiments, Faith Fang

SMU Journal of Undergraduate Research

The Cryogenic Dark Matter Search (SuperCDMS) is an international collaboration designed to search for and detect dark matter particles, which make up ~85% of the matter in the universe. The plate-out, or deposition of naturally occurring radioactive decay byproducts onto surfaces, can create backgrounds that interfere with dark matter detection experiments. In the first series of these experiments, we analyze the amount of radon progeny, 214Pb and 214Bi, that plate-out on polycarbonate samples while controlling factors such as electric charge and airflow. These samples are exposed to radon-spiked nitrogen gas in a polycarbonate wind tunnel to simulate plate-out conditions in …

Volume 8, Issue 1 Front Matter, Joshua Ange

SMU Journal of Undergraduate Research

No abstract provided.

Acute Ingestion Of Dark Chocolate Fails To Affect Running Economy In Recreational Female Runners, Bianca J. De Lucia, Beau Kjerulf Greer, Christopher B. Taber

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 5: Issue 1, Article 1, 2024. Ingestion of dark chocolate (DC), a dietary source high in flavanols, may increase nitric oxide bioavailability. Elevating blood nitric oxide concentrations may augment metabolic efficiency by reducing the amount of oxygen or energy needed to perform a given task. Utilizing a crossover design, the purpose of this study was to investigate the effect of acute ingestion of DC on running economy (RE). Nineteen recreationally trained females (age: 20±1 years) volunteered for this investigation, with 16 completing all procedures (n = 16). Two-hours before RE assessment, participants consumed …

The Cetacean Sanctuary: A Sea Of Unknowns, Jason N. Bruck

Faculty Publications

Housing cetaceans in netted sea pens is not new and is common for many accredited managed- care facilities. Hence, the distinction between sanctuary and sea pen is more about the philosophies of those who run these sanctuary facilities, the effects of these philosophies on the animals’ welfare, and how proponents of these sanctuaries fund the care of these animals. Here, I consider what plans exist for cetacean sanctuaries and discuss the caveats and challenges associated with this form of activist-managed captivity. One goal for stakeholders should be to disregard the emotional connotations of the word “sanctuary” …

Sex And Cross-Sex Testosterone Treatment Alters Gamma-Hydroxybutyrate Acid Toxicokinetics And Toxicodynamics In Rats, Qing Zhang, Hao Wei, Annie Lee, Melanie A. Felmlee

Pacific Faculty Work

Γ-hydroxybutyric acid (GHB) is widely abused due to its sedative/hypnotic and euphoric effects. In recent years, GHB use has witnessed a notable rise within the LGBTQ+ community. GHB is a substrate of monocarboxylate transporters (MCTs) and exhibits nonlinear toxicokinetics, characterized by saturable metabolism, absorption, and renal reabsorption. This study investigates the impact of exogenous testosterone administration on GHB toxicokinetics and toxicodynamics, exploring the potential of MCT1 inhibition as a strategy to counteract toxicity. Ovariectomized (OVX) females and castrated (CST) male Sprague Dawley rats were treated with testosterone or placebo for 21 days. GHB was administered at two doses (1000 mg/kg …

The Impact Of Chronic Comorbidities On Outcomes In Acute Exacerbations Of Idiopathic Pulmonary Fibrosis, Saqib H. Baig, Erika J. Yoo

Division of Pulmonary, Allergy, and Critical Care Medicine Faculty Papers

INTRODUCTION: Idiopathic pulmonary fibrosis is a chronic progressive lung disease of unknown cause with a high associated mortality. We aimed to compare the impact of chronic medical conditions on hospital outcomes of patients with acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF).

METHODS: This was a retrospective cohort study using the NIS database from 2016 to 2018. We included patients aged 60 and older hospitalized in academic medical centers with the diagnoses of IPF and acute respiratory failure. We examined factors associated with hospital mortality and length of stay (LOS) using survey-weighted multivariate logistic and negative binomial regression.

RESULTS: Out of …

Reflection, Reflexivity, Learning And The Influence Of Formalised And Experiential Piano Training, Dorothy Li

The Qualitative Report

This autoethnographic study examines how music learning is influenced by teachers and socio-cultural environments and how this influences not only our musical journeys but the way we view our lives, of the progress we have made, the goals in which we hope to achieve, and the way we perceive we will achieve them. This study explores how my musical background, understanding, learning, music-making abilities, and skills have shaped my present beliefs, attitudes and identity as a musician, educator, and researcher. Focusing on teacher pedagogy and practice, the study reveals how prevailing teacher-centred and didactic approaches to teaching impact the perspectives …

Trump Leads Haley In Final Cnn/Unh New Hampshire Primary Poll 1/21/2024, Unh Survey Center

All UNH Survey Center Polls

Former President Donald Trump leads former South Carolina Governor Nikki Haley by 11 percentage points in New Hampshire’s first in the nation presidential primary. Haley holds a significant lead among undeclared (“independent”) voters, but this is not likely to lead to a Haley victory as Trump holds a wider lead among registered Republicans. Immigration is the most important issue to GOP primary voters.

Constitutional Clash: Labor, Capital, And Democracy, Kate Andrias

Northwestern University Law Review

In the last few years, workers have engaged in organizing and strike activity at levels not seen in decades; state and local legislators have enacted innovative workplace and social welfare legislation; and the National Labor Relations Board has advanced ambitious new interpretations of its governing statute. Viewed collectively, these efforts—“labor’s” efforts for short—seek not only to redefine the contours of labor law. They also present an incipient challenge to our constitutional order. If realized, labor’s vision would extend democratic values, including freedom of speech and association, into the putatively private domain of the workplace. It would also support the Constitution’s …

Data Is What Data Does: Regulating Based On Harm And Risk Instead Of Sensitive Data, Daniel J. Solove

Northwestern University Law Review

Heightened protection for sensitive data is becoming quite trendy in privacy laws around the world. Originating in European Union (EU) data protection law and included in the EU’s General Data Protection Regulation, sensitive data singles out certain categories of personal data for extra protection. Commonly recognized special categories of sensitive data include racial or ethnic origin, political opinions, religious or philosophical beliefs, trade union membership, health, sexual orientation and sex life, and biometric and genetic data.

Although heightened protection for sensitive data appropriately recognizes that not all situations involving personal data should be protected uniformly, the sensitive data approach is …

Modifying Peptide/Lipid-Associated Nucleic Acids (Planas) For Crispr/Cas9 Ribonucleoprotein Delivery, Abdulelah Alhazza, Parvin Mahdipoor, Ryley Hall, Arthur Manda, Sandeep Lohan, Keykavous Parang, Hamidreza Montazeri Aliabadi

Pharmacy Faculty Articles and Research

With the first reports on the possibility of genome editing by Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-associated protein (Cas)9 surfacing in 2005, the enthusiasm for protein silencing via nucleic acid delivery experienced a resurgence following a period of diminished enthusiasm due to challenges in delivering small interfering RNAs (siRNA), especially in vivo. However, delivering the components necessary for this approach into the nucleus is challenging, maybe even more than the cytoplasmic delivery of siRNA. We previously reported the birth of peptide/lipid-associated nucleic acids (PLANAs) for siRNA delivery. This project was designed to investigate the efficiency of …

Occupational Therapy’S Opportunity To Impact Care At The End Of Life, Macey Genzlinger, Mackenzie L. Feldhacker

Student Journal of Occupational Therapy

Navigating and managing the end of life can be difficult. The focus of occupational therapy in care at the end of life is to aid the patient and caregiver through these challenges by facilitating improved safety, comfort, and quality of life through the participation in meaningful occupations. Despite the ways that occupational therapy benefits these patients, occupational therapy involvement in care at the end of life is misunderstood, under-researched, and underutilized. There is a general lack of awareness regarding this topic and a stigma that occupational therapy focuses only on rehabilitation and therefore does not belong in care at the …

Ecological Assessment Of Drainage Water Input On The Water Quality Of A Coastal Estuary, Mediterranean Coast Of Egypt, Fatma A. Zaghloul, Hoda A. E. Hemaida, Hayat M. Faragallah, Ahmed A. Radwan

Blue Economy

El Mex Bay, located west of Alexandria City, is identified as a hot spot of pollution along the Mediterranean coast of Egypt. It is a large, shallow, and turbid water body of socioeconomic importance. However, El Mex Bay receives a large amount of untreated industrial wastewater, as well as agricultural runoff from different land-based sources.

A comprehensive environmental study was carried out seasonally during 2020-2021. To evaluate the effect of this discharged wastewater on the water quality of El Mex Bay.

The physicochemical parameters were measured at both the surface and near-bottom water at nine stations.

Principal component analysis indicated …

Chronic Pain Interventions: Considering Hypnotherapy As A Viable Treatment Option, Madelyn Isom

Student Works

Chronic pain is a widespread and debilitating condition, demanding advancements in current interventions. Conventional medical paradigms have traditionally treated the mind and body separately, but advancement has advocated shifts toward more integrated mind-body approaches to address holistic health. Despite prevailing skepticism and friction within patient-doctor relationships surrounding hypnosis, there is substantial support for its use as a pain management tool (Declercq, 2023; Thompson et al., 2019). This analysis explores the potential of hypnosis as a viable treatment for chronic pain, highlighting its merits and addressing current research limitations. Noteworthy findings underscore hypnosis’ distinctive influence on the physical body through mental …

The Relative Strength Of Emotion Regulation, Narcissistic Personality, And Self-Esteem On Motives To Hookup, Kristen Montiel

Walden Dissertations and Doctoral Studies

No abstract provided.

A Case For Better Monitoring And Preventing Hate Crimes In The United States, Madhawa Palihapitiya, Muhammed M. Hasan, Kelsey Edmond, Jack T. Sherman, Kathryn Butterworth, Karina Zeferino

Center for Peace, Democracy and Development Publications

This report is a joint publication of the Center for Peace, Democracy, and Development (CPDD) through its conflict early warning arm, the Conflict Early Warning Analytics Program (CEWAP) and the TRUST Network (TN), which is the first conflict early warning system in the United States. CEWAP is the conflict early warning analytical hub of the TRUST Network. Together, CEWAP and the TRUST Network aim to expand the utilization of authentic community-based conflict early warning and early response through practice, research, technology development, training, and community empowerment.

This report focuses on hate crimes, hate groups and their connection to domestic extremism, …