Digital Commons Network^™

Enhancing Antibody Responses By Multivalent Antigen Display On Thymus-Independent Dna Origami Scaffolds, Eike-Christian Wamhoff, James Brett Case, Shilpa Sanapala, Michael S Diamond, Et Al.

2020-Current year OA Pubs

Protein-based virus-like particles (P-VLPs) are commonly used to spatially organize antigens and enhance humoral immunity through multivalent antigen display. However, P-VLPs are thymus-dependent antigens that are themselves immunogenic and can induce B cell responses that may neutralize the platform. Here, we investigate thymus-independent DNA origami as an alternative material for multivalent antigen display using the receptor binding domain (RBD) of the SARS-CoV-2 spike protein, the primary target of neutralizing antibody responses. Sequential immunization of mice with DNA-based VLPs (DNA-VLPs) elicits protective neutralizing antibodies to SARS-CoV-2 in a manner that depends on the valency of the antigen displayed and on T …

Complement Receptor 1 Is The Human Erythrocyte Receptor For Plasmodium Vivax Erythrocyte Binding Protein, Seong-Kyun Lee, Cécile Crosnier, Paola Carolina Valenzuela-Leon, Brian L P Dizon, John P Atkinson, Jianbing Mu, Gavin J Wright, Eric Calvo, Karthigayan Gunalan, Louis H Miller

2020-Current year OA Pubs

The discovery that Africans were resistant to infection by

A Quick Recap: Discovering Cryptococcus Neoformans Capsule Mutants, Daphne Boodwa-Ko, Tamara L Doering

2020-Current year OA Pubs

No abstract provided.

Associated Factors That Supporting Toilet Training For Children With Intellectual Disabilities: A Systematic Review, Siti Jaleha, Achmad Hufad, Imas Diana Aprilia, Sunardi Sunardi

Journal of ICSAR

The basic aspect that must be mastered by children with intellectual disabilities before mastering other self-development skills is doing toilet training independently. Learning for children with intellectual disabilities in carrying out toilet training activities requires a separate technique and needs to pay attention to the factors that support the success of the program. This study aims to describe the associated factors that support toilet training for children with intellectual disabilities. This study uses a qualitative approach with a type of literature review research that seeks to describe the related factors that support toilet training for children with intellectual disabilities. This …

Research Implementation Of Special Detection Elementary School Service For Children With Special Needs In Banjarmasin, Suharsiwi Suharsiwi, Halimatussa'diah Halimatussa'diah, Muhammad Hafiz Fathony, Siti Rahmah, Pajrian Noor

Journal of ICSAR

In order to shape the abilities and character of children with special needs, it is essential to provide early detection services in public elementary schools. This study, conducted in Banjarmasin, Kalimantan, examined six inclusive elementary schools with 102 children with special needs and 82 special assistant teachers. Using a descriptive qualitative approach with additional quantitative data collection through observations, interviews, and documentation, the study found that some public schools have implemented detection services for children with special needs. Special assistant teachers and coordinators were provided to supervise and support the activities of these children at school. The study concluded that …

Methods Of Islamic Religious Education For Children With Special Needs In Muslim Families In Banjarmasin, Indonesia, Mila Hasanah, Neela Afifah, Kuliyatun Kuliyatun, Norliana Norliana, Arba’Iyah Arba’Iyah

Journal of ICSAR

Children with Special Needs have different problems from children in general. They need special attention because of their limitations. Parents should pay attention to methods of Islamic Religious Education for Children with Special Needs to support children's development. The research method used is field research with a multi-site-based qualitative approach. The subjects in this study were 5 Muslim families from 5 sub-districts in the city of Banjarmasin, who had children with special needs in the mild category and had applied various methods of Islamic religious education and were accepted at the Inclusion State Elementary School in the city of Banjarmasin. …

The Integrated Sexual And Reproductive Health Learning Model For Children With Special Needs In West Java, East Java And North Sumatra Province, Ana Fatimatuzzahra, Endang Rochyadi, Riksma Nurhami Akhlan, Een Ratnengsih

Journal of ICSAR

The implementation of Sexual and Reproductive Health (SRH) Education in Special Schools is starting to get special attention. Having a Special Program designed for Children with Special Needs is an important factor that SRH’s material must be taught in Special Schools. However, in reality this Special Program is not comprehensive in delivering SRH’s material, so that it is widely spread in several other subjects such as Sciences, Religion, Character, Sports and Citizenship Education. The research aims to see the implementation of the SRH learning model in an integrated approach with those subjects that conducted by teachers in West Java, East …

"Unveiling Predatory Publication: Safeguarding The Integrity Of Nurse Researchers", Remya U R, Mamatha Shivananda Pai, Baby S Nayak

Manipal Journal of Nursing and Health Sciences

No abstract provided.

Coping Strategies During The Covid-19 Pandemic Among The Undergraduate Nursing Students Attending Virtual Classes In Selected Nursing Institutions Of Udupi Taluk, Karnataka., Rohan Shettigar Mr, Karthik Gavalkar Mr, Jeeshpa Karkera Ms, Pooja P Ms, Swathi Shenoy Ms, Pratibha Kamath, Radhika R. R Pai Dr

Manipal Journal of Nursing and Health Sciences

Introduction

Psychological and sociocognitive behavior changes will occur during the Covid-19 pandemic, especially concerning students’ academic activities, which might impact one's health and well-being. As a result of this, it could result in dysfunctional behaviors and unhealthy lifestyles, which may indicate a shift in well-being that calls for quick attention and intervention.

Methods

A descriptive survey design was adopted for the present study to identify the coping strategies adopted by nursing students during COVID-19. The study was conducted among 60 fourth-year B.Sc. Nursing students using the purposive sampling technique. The data was collected using structured questionnaires on coping strategies adopted …

A Study To Assess The Effect Of Back Massage On Amount Of Breast Milk Among Mothers Of Neonates Admitted In Nicu At A Selected Hospital, Calicut., Aswathi A, Soya K

Manipal Journal of Nursing and Health Sciences

Abstract

Breastfeeding is one of the most natural act and intimate human interaction. Separation of mother and baby after birth creates an interruption in maintaining lactation. The main objective of this study was to identify the effect of back massage on amount of breast milk among mothers of neonates admitted in NICU. An experimental pretest-posttest control group design was adopted. The tools used were baseline proforma, calibrated breastmilk measuring cup and breast milk volume diary. Subjects were selected using consecutive sampling and allocated as 30 in each group. As first step baseline data were collected. Then the amount of expressed …

Modified Himawari Technique For Comminuted Patella Fractures: A Case Report - An Economically Yet Rigidly Efficient Option, Leong Li Theng Dr, Eyrique Goh Boay Heong Dr

Manipal Journal of Nursing and Health Sciences

Comminuted patella fracture is a tricky and complicated case to manage and yet a common fracture. It’s often complicated with post operative pseudoarthrosis, malunion, poor rehabilitation and reduced knee range of motion. Tension band wiring, Cerclarge wiring and screw fixation are the common surgical modalities however it’s unable to hold peripherally scattered fragments in place rigidly. It is often associated with failure osteosynthesis, fracture displacement, resulting in post op osteoarthritis. Here we demonstrate a case of a modification of the original Himawari Technique as a much cost-effective method compared to the original, while being a superior treatment option with good …

Provision And Long-Term Assessment Of A Specialized Clinical Evidence-Based Practice Curriculum For Master Of Social Work Students, Susan Reay

Social Work Faculty Publications

This study investigated social workers’ knowledge of the common elements in evidence-based practice to treat youth mental health conditions following a specialized curriculum during their Master of Social Work (MSW) education. Participants’ knowledge was measured during their MSW education and in their first 5 years of social work practice after graduation. The quantitative study measured participants’ knowledge of common elements three times; 86 social workers participated in the study with 67 sets of scores at three data points. Study results showed that participants knew more after completing the curriculum but knew less one to five years after graduation. Overall, however, …

Recommendations From People Who Use Drugs In Philadelphia, Pa About Structuring Point-Of-Care Drug Checking, Megan K. Reed, Elias Borne, Tracy Esteves Camacho, Morgan Kelly, Kristin L. Rising

Department of Emergency Medicine Faculty Papers

Background

Adulterants, such as fentanyl and xylazine, among others, are present in a high percentage of the illicit drug supply, increasing the risk for overdose and other adverse health events among people who use drugs (PWUD). Point-of-care drug checking identifes components of a drug sample and delivers results consumers. To successfully meet the diverse needs of PWUD, more information is needed about the utility of drug checking, motivations for using services contextualized in broader comments on the drug supply, hypothesized actions to be taken after receiving drug checking results, and the ideal structure of a program.

Methods

In December 2021, …

Tackling Vulnerabilities Through Corporate Duties, Jingchen Zhao

Catholic University Law Review

In this article, and drawing on the work of Fineman and others, we use a vulnerability lens as a device to emphasize the protection that could be offered to vulnerable parties in corporations through directors’ duties. By situating corporations in the vulnerability paradigm, we will discuss the limitations of formal equality and clarify the role played by corporate law. The increasingly blurred distinction between private law and public law will be discussed to rationalize the protection of the vulnerable through collective responsibility. Vulnerability theory mediates conflicts between calls for “regulatory state policies” and “individual responsibility” to supervise and monitor corporate …

Increasing Physical Activity In The 65 And Older Population, Misti M. Hollingsworth

Dissertations

The purpose of this DNP project is to increase the physical activity, flexibility, and pain levels of the 65 and over population to comply with the CDC's MVPA of 150 minutes per week through a practice quality improvement project. This change will involve an order for patients to attend a free exercise program, address the medical benefits of PA, address perceived barriers to PA, and provide printed PA written resources including exercises and stretching recommendations for the 65 years of age and older patient population in a Chiropractic office in Southwest Florida.

Reactive Amine Functionalized Microelectrode Arrays Provide Short-Term Benefit But Long-Term Detriment To In Vivo Recording Performance, Lindsey N. Druschel, Pierce E. Boucher, George F. Hoeferlin, Dhariyat M. Menendez, Jonathan L. Duncan, Jeffrey R. Capadona

Faculty Scholarship

Intracortical microelectrode arrays (MEAs) are used for recording neural signals. However, indwelling devices result in chronic neuroinflammation, which leads to decreased recording performance through degradation of the device and surrounding tissue. Coating the MEAs with bioactive molecules is being explored to mitigate neuroinflammation. Such approaches often require an intermediate functionalization step such as (3-aminopropyl)triethoxysilane (APTES), which serves as a linker. However, the standalone effect of this intermediate step has not been previously characterized. Here, we investigated the effect of coating MEAs with APTES by comparing APTES-coated to uncoated controls in vivo and ex vivo. First, we measured water contact angles …

The Relationship Between Traffic Congestion And Quality Of Life, Amer Alhusinan

Journal of Police and Legal Sciences

The problem of traffic congestion is one of the most serious problems that affect people because of the many negative effects it has on the quality of life and well-being of people, which include health, environmental, psychological and aesthetic aspects. With the increase in the number of vehicles and means of transportation, especially in large, densely populated cities, the problem of traffic congestion is exacerbated, which results in many negative effects, such as air pollution resulting from vehicle exhausts, which leads to chest diseases and suffocation, as well as the transfer of toxic substances present in fuel such as lead …

Research Progress On Polyphenols In Chestnut Rose Fruit, Yin Yanyan, Zhang Jian, Lu Lunwei, Li Lulu, Zhang Deqin

Food and Machinery

Chestnut rose fruit, known as "Three King fruits", has high edible value and medicinal value. Polyphenols are the second major functional component of chestnut rose fruit with pharmacological and health functions such as antioxidant, regulation of glucose and lipid metabolism, anti-inflammatory and bacteriostatic, antialcoholism and liver protection, and have great potential for food development. This review summarized the research progress of the classification, extraction, qualitative and quantitative analysis, and bioactivity of chestnut rose fruit polyphenols in recent years and prospected the future development direction.

Selective Neural Inhibition Via Photobiomodulation Alleviates Behavioral Hypersensitivity Associated With Small Sensory Fiber Activation, Andrew Buzza, Kalista Tapas, Junqi Zhuo, Stephen J. Lewis, Michael W. Jenkins, Michael Moffitt

Faculty Scholarship

Objective: Photobiomodulation at higher irradiances has great potential as a pain-alleviating method that selectively inhibits small diameter nerve fibers and corresponding sensory experiences, such as nociception and heat sensation. The longevity and magnitude of these effects as a function of laser irradiation parameters at the nerve was explored. Methods: In a rodent chronic pain model (spared nerve injury—SNI), light was applied directly at the sural nerve with four delivery schemes: two irradiance levels (7.64 and 2.55 W/cm2) for two durations each, corresponding to either 4.8 or 14.4 J total energy, and the effect on sensory hypersensitivities was evaluated. Results: At …

Asosiasi Jaminan Sosial Dengan Partisipasi Kerja Penduduk Lansia Di Indonesia, Evelyn Fairuz Wibowo, Dwini Handayani

Jurnal Ekonomi Kependudukan dan Keluarga

Indonesia has entered a period of aging population. The number of elderly people has increased sharply without social security ownership, making the elderly population vulnerable to poverty. Financial demands make the elderly must continue to work in their old age, even though their biological and psychological conditions are declining. The study aims to analyzes the effect of social insurance (pension insurance and health insurance) on the work participation of the elderly population which is controlled based on individual, household, and social characteristics. Using secondary data from the 2020 National Socioeconomic Survey and analyzed using logistic biner regression, this …

The Vulnerability Of Youths Labor Market During Covid-19 Pandemic: Evidence From The Indonesia’S Labor Force Survey, Qisha Quarina, Ariqoh Wahyu Armadhani, Akmal Shalahuddin, Owen Alberto Liem

Jurnal Ekonomi Kependudukan dan Keluarga

This study aims to investigate the youth labor market vulnerability during COVID-19 pandemic crisis in Indonesia in terms of their incidence of unemployment, duration of job search, and the probability to experience work stoppage. We utilize the Indonesian Labor Force Survey in the periods of 2019-2021, to capture the period before and during the pandemic. A descriptive analysis is used to provide an overview of the youth labor market condition before and during the pandemic. The incidence of unemployment and the job search duration analyses are investigated utilizing the probit and non-parametric Kaplan-Meier method respectively. While the probability of experiencing …

Customer Decision To Save In Sharia Banks Following A Ransomware Attack: An Analysis Of The Role Of Word Of Mouth, Trust, Perception Of Cybersecurity, And Perception Of Sharia Label, Sudana Sudana, Lina Marlina

BISNIS & BIROKRASI: Jurnal Ilmu Administrasi dan Organisasi

Ransomware attacks on Islamic banking institutions can lead to a decline in public interest in saving. To stimulate the growth of savings, it is crucial to investigate the determinants influencing customer decision to save their money in Islamic banking institutions following a ransomware attack. This study implemented a unique approach in examining the impact of perceptions of cybersecurity and Sharia label on the decision to save in Sharia banks in Indonesia subsequent to a ransomware attack. It aims to explore the intervening role of trust and Word of Mouth (WOM) in information dissemination and analyze how the Sharia label can …

On Modeling Arterial Blood Flow With Or Without Solute Transport And In Presence Of Atherosclerosis, Daniel N. Riahi, Saulo Orizaga

School of Mathematical & Statistical Sciences Faculty Publications

In this article, we review previous studies of modeling problems for blood flow with or without transport of a solute in a section of arterial blood flow and in the presence of atherosclerosis. Moreover, we review problems of bio-fluid dynamics within the field of biophysics. In most modeling cases, the presence of red blood cells in the plasma is taken into account either by using a two-phase flow approach, where blood plasma is considered as one phase and red blood cells are counted as another phase, or by using a variable viscosity formula that accounts for the amount of hematocrit …

Cardiometabolic Health: Actionable Prevention Strategies And New Care Models, Omar Leonards, David Aguilar

School of Medicine Faculty Publications

No abstract provided.

Autophagy And Cell Wall Integrity Pathways Coordinately Regulate The Development And Pathogenicity Through Moatg4 Phosphorylation In Magnaporthe Oryzae, Pusheng Guo, Yurong Wang, Jiayun Xu, Zhixiang Yang, Ziqi Zhang, Jinyi Qian, Jiexiong Hu, Ziyi Yin, Leiyun Yang, Muxing Liu, Xinyu Liu, Gang Li, Haifeng Zhang, Ryan Rumsey, Ping Wang, Zhengguang Zhang

School of Medicine Faculty Publications

Autophagy and Cell wall integrity (CWI) signaling are critical stress-responsive processes during fungal infection of host plants. In the rice blast fungus Magnaporthe oryzae, autophagy-related (ATG) proteins phosphorylate CWI kinases to regulate virulence; however, how autophagy interplays with CWI signaling to coordinate such regulation remains unknown. Here, we have identified the phosphorylation of ATG protein MoAtg4 as an important process in the coordination between autophagy and CWI in M. oryzae. The ATG kinase MoAtg1 phosphorylates MoAtg4 to inhibit the deconjugation and recycling of the key ATG protein MoAtg8. At the same time, MoMkk1, a core kinase of CWI, also phosphorylates …

Analysis Of The Indonesian Government’S Decision To Buy Rafale Dassault Aircraft From France, Difajrin Septiawan Ali Mardin, Arie Kusuma Paksi, Nur Azizah

Jurnal Wacana Politik

This research aims to explain and analyze Indonesia’s decision to buy the Dassault Rafale fighter aircraft from France in 2022. It is known that Indonesia will retire its old F-5 Tiger fighter aircraft and its outdated technology. Indonesia’s purchase of Dassault Rafale fighter aircraft to increase air defense capabilities, strengthen bilateral cooperation and increase national military capabilities. Several options for Indonesia to choose which fighter aircraft to buy, namely Gripen from Sweden, Eurofighter from Austria, Dassault Rafale from France, and Sukhoi Su-35 from Russia. The theory used in this research is Rational Choice. This study used descriptive qualitative method. In …

Development Of A Culinary Medicine Toolkit To Improve Implementation Of Virtual Cooking Classes For Low-Income Adults With Type 2 Diabetes, David Ai, Natalia I Heredia, Vanessa Cruz, Diana C Guevara, Shreela V Sharma, Dolores Woods, Melisa Danho, John Wesley Mcwhorter

Faculty, Staff and Student Publications

Culinary medicine (CM) addresses diseases through nutrition and culinary education. To promote access to educational material for people with diabetes and engagement in virtual classes, we created a virtual culinary medicine toolkit (VCMT) sensitive to literacy levels and language preferences. The VCMT was developed to accompany existing virtual CM programs and help improve participant interaction and retention, offering educational materials for providers and participants. The provider VCMT offers level-setting education to reduce mixed nutrition messaging, including educational resources discussing inclusive nutrition and mindful eating topics. Each handout has a QR code and link to engaging, animated videos that provide further …

Association Between Regulatory T Cells And Ischemic Heart Disease: A Mendelian Randomization Study, Yucheng Hou, Ke Si, Jingyue Yang, Tan Liu, Basel Abdelazeem, Nonthikorn Theerasuwipakorn, Jingwei Zhao, Zhenya Shen

Faculty, Staff and Student Publications

BACKGROUND: An imbalance of innate and acquired immune responses is significantly involved in the pathophysiology of coronary atherosclerosis and the occurrence of ischemic heart disease (IHD). Regulatory T cells (Tregs) play an essential regulatory role in atherosclerotic plaque formation and maintenance; therefore, dysfunction of Tregs triggers the formation of atherosclerotic plaques and accelerates their progression. However, due to the inherent limitations of observational research, clinical evidence is limited concerning the relationship between the variation in peripheral Tregs and the risk of IHD, and the cause-and-effect relationship between these factors is unclear. Mendelian randomization (MR) uses genetic variation as a proxy …

Cardiometabolic Health: Actionable Prevention Strategies And New Care Models, Omar Leonards, David Aguilar

The Texas Heart Institute Journal

No abstract provided.

A Study To Assess The Effectiveness Of Nurse-Led Rehabilitation Package On Knowledge And Skill Regarding Homecare Management Among Caregivers Of Neurosurgical Patients At Selected Hospital, Chennai., Arulmozhi Manavazhagan, Deepa M

Manipal Journal of Nursing and Health Sciences

Background: The neurosurgical patients require special care not only during the hospital stay but also in the home after discharge. Long-term care at home is provided by the caregivers of the patients at their home. Caregivers are referred to as “secondary patients,” who face lot of difficulties while they care for the neurosurgical patients at home.. Aim: The present study aims to assess the effectiveness of nurse-led rehabilitation package on knowledge and skill regarding homecare management among caregivers of neurosurgical patients at selected hospital, Chennai. Method: The research approach was quantitative in nature and Pre-experimental one group pre and post-test …