Digital Commons Network^™

A Healthful Plant-Based Diet Is Associated With Lower Type 2 Diabetes Risk Via Improved Metabolic State And Organ Function: A Prospective Cohort Study, Alysha S. Thompson, Catharina J. Candussi, Anna Tresserra-Rimbau, Amy Jennings, Nicola P. Bondonno, Claire Hill, Solomon A. Sowah, Aedín Cassidy, Tilman Kühn

Research outputs 2022 to 2026

Background: Plant-based diets are becoming increasingly popular due to favourable environmental footprints and have been associated with lower risk of type 2 diabetes mellitus (T2DM). Here, we investigated the potential mechanisms to explain the lower T2DM risk observed among individuals following plant-based diets. Methods: Prospective data from the UK Biobank, a cohort study of participants aged 40 to 69 years at baseline, was evaluated. Associations between healthful and unhealthful plant-based indices (hPDI and uPDI) and T2DM risk were analysed by multivariable Cox regression models, followed by causal mediation analyses to investigate which cardiometabolic risk factors explained the observed associations. Results: …

Dynamic Prognosis Prediction For Patients On Dapt After Drug-Eluting Stent Implantation: Model Development And Validation, Fang Li, Laila Rasmy, Yang Xiang, Jingna Feng, Ahmed Abdelhameed, Xinyue Hu, Zenan Sun, David Aguilar, Abhijeet Dhoble, Jingcheng Du, Qing Wang, Shuteng Niu, Yifang Dang, Xinyuan Zhang, Ziqian Xie, Yi Nian, Jianping He, Yujia Zhou, Jianfu Li, Mattia Prosperi, Jiang Bian, Degui Zhi, Cui Tao

School of Medicine Faculty Publications

BACKGROUND: The rapid evolution of artificial intelligence (AI) in conjunction with recent updates in dual antiplatelet therapy (DAPT) management guidelines emphasizes the necessity for innovative models to predict ischemic or bleeding events after drug-eluting stent implantation. Leveraging AI for dynamic prediction has the potential to revolutionize risk stratification and provide personalized decision support for DAPT management. METHODS AND RESULTS: We developed and validated a new AI-based pipeline using retrospective data of drug-eluting stent-treated patients, sourced from the Cerner Health Facts data set (n=98 236) and Optum’s de-identified Clinformatics Data Mart Database (n=9978). The 36 months following drug-eluting stent implantation were …

Gamification And The Effects On Confidence In The Student Nurse, Gerald R. Connors

DNP and Student Works

Nursing educators are challenged with conveying vast amounts of complex nursing arts and science content to learners every day. The relationship between learner and nursing educator should be one of collaboration to ensure the smooth instruction of broad and deep nursing concepts. Knowledge acquisition, confidence, learner engagement and enjoyment are critical to the learning process, but often students are challenged with these behaviors (Garrison et al., 2021). Research in the last five years has suggested that the use of gaming in the nongaming setting, like clinical healthcare, can strengthen knowledge, increase content retention, and subsequently increase confidence (Marquez-Hernandez et al., …

Profess 12: Project Report 5: The Profess 12 Summer School - Evaluation, Una Beagon, Ruchita Jani, Janet Mckennedy, Brian Bowe, Margaret Morgan, Rosalind M Henry

Reports

This report outlines the evaluation of the summer school which was a key element of the PROFESS 12 project. The key steps involved in the 5-day summer school along with the method by which the feedback and the reflections of the participants of the summer school were collected is described here. Thereafter, the reflections received in the form of audio and text files are analysed and themes identified from the experience of the summer school participants are explained in detail.

The survey responses from the feedback on the summer school participation are also shown graphically. This analysis helped us identify …

Economic Feasibility Of Material Waste Management “Reduction, Reuse, Recycle And Repair’ Strategies In Egypt’S Footwear Industry, Amira Motawea

Theses and Dissertations

The study aims to provide a comprehensive examination of the feasibility of waste management strategies in the leather and footwear industry, both globally and within the specific context of Egypt. It explores the benefits and challenges associated with efficiently recycling, treating, or reusing material waste generated by the footwear industry, with a particular focus on Egypt. The study begins by discussing established waste management practices in the global fashion industry and focusing on footwear material waste.

The study examines successful waste management methods and systems employed globally, highlighting their potential applicability to the Egyptian fashion sector. A key aspect of …

Fabp4 And Metabolite Profile In Lipopolysaccharide-Induced Mice Model Treated With Moringa Oleifera Ethanol Leaf Extract, Cenia P. Hanifah, Ifa Sulistiyorini, Vanessa A. Sumirat, Neni Anggraeni, Mirasari Putri, Mohammad Ghozali, Mas Rizky A.A Syamsunarno

Pharmacology and Clinical Pharmacy Research

Sepsis, a life-threatening organ dysfunction resulting from a dysregulated host response to infection, induces changes in blood cells and metabolic alterations. Fatty acid binding protein 4 (FABP4), a lipid chaperone predominantly expressed in adipose tissue, is modulated in sepsis and may contribute to metabolic and immunologic changes. Moringa oleifera (M. oleifera) leaf extract (MOLE) is known to modulate immune system activity, but its potential for treating acute inflammatory conditions like sepsis remains unclear. This study investigates the ability of MOLE to modulate metabolite and hematological profiles in lipopolysaccharide (LPS)-induced sepsis in mice. Thirty-five male Swiss Webster mice (Mus musculus) were …

War And Ip, Peter K. Yu

BYU Law Review

This Article examines wartime and postwar protection of intellectual property rights, with a focus on the Russo-Ukrainian War that broke out in February 2022. It begins by showing that armed conflicts are not new to the international intellectual property regime and that this regime already contains robust structural features and carefully drafted safeguards, limitations, and flexibilities to protect intellectual property rights holders during wartime. The Article then explores the international intellectual property obligations of countries that are parties to an armed conflict as well as those that are not directly involved but have imposed sanctions on belligerent states. This Article …

Ukraine, Urban Warfare, And Obstacles To Humanitarian Access: A Predicament Of Public International Law, Harriet Norcross Eppel

BYU Law Review

Humanitarian assistance is not carried out in a vacuum. As urban warfare historically complicates humanitarian aid’s access to civilians in war zones, Ukraine, having suffered and still facing highly publicized violence in civilian-dense areas, has encountered dire obstacles in acquiring necessary resources for civilians’ survival, including both direct and incidental attacks on humanitarian access. Thus, it is vital the international legal community take measures to mitigate current and future dangers of urban warfare, as well as design new solutions, such as strengthening current international law under which obstructing humanitarian access constitutes a violation of jus cogens principles, attempting to induce …

Garrity Immunity And The U.S. Armed Forces, Bretton H. Laudeman, Gabriel J. Chin

BYU Law Review

The U.S. military is one of the nation’s largest and most important public employers. Given the unique nature of military service, the service branches have a strong interest in ensuring the integrity of their ranks. Yet the military lacks a critical force-management tool used by every other public employer to investigate workplace misconduct: the ability to demand answers to potentially incriminating questions under Garrity v. New Jersey, 385 U.S. 493 (1967). The Garrity solution, known as “Garrity immunity,” strikes a critical balance between the government’s interests in workplace oversight and accountability with the employee’s Fifth Amendment right against self-incrimination by …

The Mef2c Gene Dose-Dependently Controls Hippocampal Neurogenesis And The Expression Of Autism-Like Behaviors, Sreetama Basu, Eun Jeoung Ro, Zhi Liu, Hyunjung Kim, Aubrey Bennett, Seungwoo Kang, Hoonkyo Suh

The Brown Foundation: Institute of Molecular Medicine

Mutations in the activity-dependent transcription factor MEF2C have been associated with several neuropsychiatric disorders. Among these, autism spectrum disorder (ASD)-related behavioral deficits are manifested. Multiple animal models that harbor mutations in Mef2c have provided compelling evidence that Mef2c is indeed an ASD gene. However, studies in mice with germline or global brain knock-out of Mef2c are limited in their ability to identify the precise neural substrates and cell types that are required for the expression of Mef2c-mediated ASD behaviors. Given the role of hippocampal neurogenesis in cognitive and social behaviors, in this study we aimed to investigate the role …

Surgical Outcome Of Postinfarction Left Ventricular Free Wall Rupture, Chan-Young Na

The Texas Heart Institute Journal

BACKGROUND: Left ventricular free wall rupture (LVFWR) is a rare and fatal complication after acute myocardial infarction. Early recognition and aggressive treatment are recommended.

METHODS: Between August 1999 and February 2023, 11 patients aged between 64 and 79 years developed LVFWR after acute myocardial infarction (mean interval, 3.5 days). Three patients had active bleeding (blowout-type LVFWR), and the other 8 patients experienced the oozing or sealed state. Eight patients were treated using a sutureless technique with Teflon felt and glue, 2 patients were treated using the primary suture closure technique, and 1 was treated using both the primary suture and …

Potential Of Endophytic Fungal Isolates In Improving Productivity And Postharvest Marketable Fruit Qualities Of Tomato, Gabriel Michael, Emmanuel M. Sangu

Tanzania Journal of Science

In Tanzania, low tomato (Solanum lycopersicum) yield and postharvest marketable fruit qualities remain significant limitations for tomato grower’s profit. Seven endophytic fungal isolates from pyrethrum and Lemongrass leaf and or flowers were evaluated to promote tomato productivity and fruit qualities. The isolates were inoculated by priming the seeds in spore suspension, and the variations in the number of germinated seeds, seedling vigour, yield and fruit qualities were compared across the treatments. It was observed that only three isolates induced more than 50% seed germination. Epf1 and Epl1 isolates showed significant promotion of seed germination (F 0.05 (pdf, 23) = 8.121 …

Progressive Public Policy Making By A Nongovernmental Organization To Assist Cameroonian Widows, Blaise K

Walden Dissertations and Doctoral Studies

No abstract provided.

The Effects Of Loneliness And Suicidal Ideation On U.S. Veterans, Sean Donnelly

Walden Dissertations and Doctoral Studies

No abstract provided.

Biosocial Criminology: Projected Criminal Behaviors Induced By Climate Changes, David Brown Sr.

Walden Dissertations and Doctoral Studies

No abstract provided.

Blood Epigenome-Wide Association Studies Of Suicide Attempt In Adults With Bipolar Disorder, Salahudeen Mirza, Camila N C Lima, Alexandra Del Favero-Campbell, Alexandre Rubinstein, Natasha Topolski, Brenda Cabrera-Mendoza, Emese H C Kovács, Hilary P Blumberg, Jenny Gringer Richards, Aislinn J Williams, John A Wemmie, Vincent A Magnotta, Jess G Fiedorowicz, Marie E Gaine, Consuelo Walss-Bass, Joao Quevedo, Jair C Soares, Gabriel R Fries

Faculty, Staff and Student Publications

Suicide attempt (SA) risk is elevated in individuals with bipolar disorder (BD), and DNA methylation patterns may serve as possible biomarkers of SA. We conducted epigenome-wide association studies (EWAS) of blood DNA methylation associated with BD and SA. DNA methylation was measured at >700,000 positions in a discovery cohort of n = 84 adults with BD with a history of SA (BD/SA), n = 79 adults with BD without history of SA (BD/non-SA), and n = 76 non-psychiatric controls (CON). EWAS revealed six differentially methylated positions (DMPs) and seven differentially methylated regions (DMRs) between BD/SA and BD/non-SA, with multiple immune-related …

Delays In Intervention: A Post-Mortem Of The Uk-Reboa And Cryostat-2 Trials, Bryan A Cotton

Faculty, Staff and Student Publications

No abstract provided.

A Novel Polymer-Encapsulated Multi-Imaging Modality Fiducial Marker With Positive Signal Contrast For Image-Guided Radiation Therapy, Li Wang, Jeremiah Sanders, John F Ward, Stephen R Lee, Falk Poenisch, David Michael Swanson, Narayan Sahoo, Xiaorong Ronald Zhu, Jingfei Ma, Rajat J Kudchadker, Seungtaek L Choi, Quynh-Nhu Nguyen, Lauren L Mayo, Shalin J Shah, Steven J Frank

Faculty, Staff and Student Publications

BACKGROUND: Current fiducial markers (FMs) in external-beam radiotherapy (EBRT) for prostate cancer (PCa) cannot be positively visualized on magnetic resonance imaging (MRI) and create dose perturbation and significant imaging artifacts on computed tomography (CT) and MRI. We report our initial experience with clinical imaging of a novel multimodality FM, NOVA.

METHODS: We tested Gold Anchor [G-FM], BiomarC [carbon, C-FM], and NOVA FMs in phantoms imaged with kilovoltage (kV) X-rays, transrectal ultrasound (TRUS), CT, and MRI. Artifacts of the FMs on CT were quantified by the relative streak artifacts level (rSAL) metric. Proton dose perturbations (PDPs) were measured with Gafchromic EBT3 …

Management Of Infliximab Refractory Immune Checkpoint Inhibitor Gastrointestinal Toxicity: A Multicenter Case Series, Catriona Harvey, Kazi J Nahar, Janet Mckeown, Serigne N Lo, Sheima Farag, Nadia Yousaf, Kate Young, Liselotte Tas, Aafke Meerveld-Eggink, Christian Blank, Austin Thomas, Jennifer Mcquade, Bastian Schilling, Douglas B Johnson, Roberto Martín Huertas, Ana Arance, Joanna Lee, Lisa Zimmer, Georgina V Long, Matteo S Carlino, Yinghong Wang, Alexander Maxwell Menzies

Faculty, Staff and Student Publications

Background: Immune checkpoint inhibitor (ICI) gastrointestinal toxicity (gastritis, enteritis, colitis) is a major cause of morbidity and treatment-related death. Guidelines agree steroid-refractory cases warrant infliximab, however best management of infliximab-refractory ICI gastrointestinal toxicity (IRIGItox) is unknown.

Methods: We conducted an international multicenter retrospective case series. IRIGItox was defined as failure of symptom resolution ≤grade 1 (Common Terminology Criteria for Adverse Events V.5.0) following ≥2 infliximab doses or failure of symptom resolution ≤grade 2 after one dose. Data were extracted regarding demographics, steroid use, response to treatment, and survival outcomes. Toxicity was graded at symptom onset and time of infliximab failure. …

Cytoskeleton Remodeling Induced By Smyd2 Methyltransferase Drives Breast Cancer Metastasis, Alexandre G Casanova, Gael S Roth, Simone Hausmann, Xiaoyin Lu, Ludivine J M Bischoff, Emilie M Froeliger, Lucid Belmudes, Ekaterina Bourova-Flin, Natasha M Flores, Ana Morales Benitez, Tourkian Chasan, Marcello Caporicci, Jessica Vayr, Sandrine Blanchet, Francesco Ielasi, Sophie Rousseaux, Pierre Hainaut, Or Gozani, Muriel Le Romancer, Yohann Couté, Andres Palencia, Pawel K Mazur, Nicolas Reynoird

Faculty, Staff and Student Publications

Malignant forms of breast cancer refractory to existing therapies remain a major unmet health issue, primarily due to metastatic spread. A better understanding of the mechanisms at play will provide better insights for alternative treatments to prevent breast cancer cell dispersion. Here, we identify the lysine methyltransferase SMYD2 as a clinically actionable master regulator of breast cancer metastasis. While SMYD2 is overexpressed in aggressive breast cancers, we notice that it is not required for primary tumor growth. However, mammary-epithelium specific SMYD2 ablation increases mouse overall survival by blocking the primary tumor cell ability to metastasize. Mechanistically, we identify BCAR3 as …

Measures Of Resting-State Brain Network Segregation And Integration Vary In Relation To Data Quantity: Implications For Within And Between Subject Comparisons Of Functional Brain Network Organization, Liang Han, Micaela Y Chan, Phillip F Agres, Ezra Winter-Nelson, Ziwei Zhang, Gagan S Wig

Faculty, Staff and Student Publications

Measures of functional brain network segregation and integration vary with an individual's age, cognitive ability, and health status. Based on these relationships, these measures are frequently examined to study and quantify large-scale patterns of network organization in both basic and applied research settings. However, there is limited information on the stability and reliability of the network measures as applied to functional time-series; these measurement properties are critical to understand if the measures are to be used for individualized characterization of brain networks. We examine measurement reliability using several human datasets (Midnight Scan Club and Human Connectome Project [both Young Adult …

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

Neuropsychological Malingering Determination: The Illusion Of Scientific Lie Detection, Chunlin Leonhard, Christoph Leonhard

Georgia Law Review

Humans believe that other humans lie, especially when stakes are high. Stakes can be very high in a courtroom, from substantial amounts of monetary damages in civil litigation to liberty or life in criminal cases. One of the most frequently disputed issues in U.S. courts is whether litigants are malingering when they allege physical or mental conditions for which they are seeking damages or which would allow them to avoid criminal punishment. Understandably, creating a scientific method to detect lies is very appealing to all persons engaged in lie detection. Neuropsychologists claim that they can use neuropsychological assessment tests (Malingering …

Redefining The Injury-In-Fact: Treating Personally Identifying Information As Bailed Property, Austin Headrick

Georgia Law Review

There is a long-existing circuit split among federal courts of appeals as to whether an individual has standing under Article III of the United States Constitution when their personally identifying information (PII) is stolen from an entity to which they entrusted it such as a hospital or bank. Federal courts disagree as to whether an individual whose PII has been stolen—without more—has suffered an injury-in-fact, a necessary element of standing. The disagreement between the courts centers on whether the injury-in-fact has already occurred at the time the PII is stolen or whether the injury occurs once the PII has been …

Potential Of Endophytic Fungal Isolates In Improving Productivity And Postharvest Marketable Fruit Qualities Of Tomato, Gabriel Michael, Emmanuel M. Sangu

Tanzania Journal of Science

In Tanzania, low tomato (Solanum lycopersicum) yield and postharvest marketable fruit qualities remain significant limitations for tomato grower’s profit. Seven endophytic fungal isolates from pyrethrum and Lemongrass leaf and or flowers were evaluated to promote tomato productivity and fruit qualities. The isolates were inoculated by priming the seeds in spore suspension, and the variations in the number of germinated seeds, seedling vigour, yield and fruit qualities were compared across the treatments. It was observed that only three isolates induced more than 50% seed germination. Epf1 and Epl1 isolates showed significant promotion of seed germination (F 0.05 (pdf, 23) = 8.121 …

Evaluation Of The Modulatory Effects Of Capsicum Chinensis Methanol Extract In Streptozotocin-Induced Diabetic Neuropathic Pain In Mice, Babatunde A. Alabi, Adeyinka Aderonmu, Sodiq K. Lawal, Okot-Asi T. Nku-Ekpang, Mayowa Ajayi, Olugbenga E. Iwalewa

Tanzania Journal of Science

Diabetes is one of the common causes of neuropathic pain. The first-line treatment drugs used in alleviating neuropathic pain can cause adverse effects. Therefore, the aim of this study is to evaluate the analgesic property of Capsicum chinensis, since the plant was reported to be used against chronic pain in traditional medicine. Streptozotocin-induced diabetes was adopted to model neuropathy in mice and the antihyperalgesic effect of the extract was evaluated using a hot plate test, cold allodynia test, and Randall- Selitto paw pressure test. The plasma level of pain-associated inflammatory biomarkers like interleukin-6 (IL-6) and tissue necrotic factor-α (TNF-α) was …

Microbial Quality Of Fresh Juices Sold By Street Vendors And Associated Human Health Risks: The Case Of Ilala Ward, Dar Es Salaam City, Tanzania, Juliana I. Rubaratuka, Godwill D. Mrema, Thomas J. Lyimo

Tanzania Journal of Science

Microbial food quality serves to indicate health risks associated with the consumption of contaminated foods. This study aimed to determine the microbial quality of fresh juices and the level of awareness and perception of the consumers and juice vendors at Ilala Ward, Dar es Salaam. Fresh samples of sugarcane, mango and mixed fruit juices were collected from four different sampling stations and analysed using standard methods for Total Coliform (TC), Faecal Coliform (FC) and Total Viable Count (TVC). The level of awareness and perception of 60 juice vendors and 60 consumers were also assessed by using questionnaires. The results showed …

Turmeric Dyeing Of Cotton Fabrics Using Tie-Dyeing Techniques, Pendo Bigambo, Happiness Wellah, Hadija Ngaga, Safina Kimbokota, Mbonea Mrango

Tanzania Journal of Science

Tie-dyeing is a resist-dyeing technique which for years has been used by SMEs to produce attractive textile fabrics. However, the technique is challenged by the use of synthetic dyes which are not environmentally friendly and the growing consumers’ environmental awareness. Accordingly, researchers and industrialists are forced to explore the alternative natural dyes in response to the above challenges. Among the natural source of dyes available abundantly in Tanzania, but are yet to be fully exploited for applications via tie-dyeing technique are turmeric (Curcuma longa L.) roots commonly used for food coloring. In this study turmeric roots were investigated for their …

Woody Plant Assemblages Of Recently Declared Village Land Forest Reserve In The Eastern Afromontane Biodiversity Hotspot, Samora Macrice Andrew

Tanzania Journal of Science

Understanding of species composition of village land forest reserves and their driving factors informs adequate development of effective restoration strategies and sustainable forest management of miombo woodlands. This study assessed the effects of human disturbance as well as environmental variables on woody plant species composition using 24 square plots of 10 x 10 m in a recently declared village land forest reserve in the Eastern Afromontane biodiversity hotspot of Tanzania. Ordination analysis technique canonical correspondence analysis was used to identify important vegetation gradients and significant factors that explain the spatial variation in species composition of woody plants. Results showed that, …

Synthesis Of Template-Free Flower-Like Zno Nanorods Using A Simple Chemical Bath Technique, Benard S. Mwankemwa

Tanzania Journal of Science

Flower-like ZnO nanorods were successfully synthesised using a template-free, low-temperature chemical bath deposition method. The effects of growth time on the structural, morphological, and vibrational properties of flower-like zinc oxide were investigated. X-ray diffraction (XRD) and scanning electron microscopy (SEM) indicated that the crystallite size and density of flower-like ZnO nanorods increased with increasing growth time. Raman spectroscopy confirmed the existence of specific Raman modes that correspond to the wurtzite structure of ZnO. In addition, Raman measurements revealed that increased growth time increases the Raman modes intensity of the flower-like ZnO nanorods. Moreover, the measurements of the Au/ZnO nanorods/FTO Schottky …