Digital Commons Network^™

Fertility Management In Cystinosis: A Clinical Perspective, Craig B Langman, Rowena B Delos Santos, Cybele Ghossein, Andrea M Atherton, Elena N Levtchenko, Aude Servais

2020-Current year OA Pubs

Cystinosis is a rare, inherited, lysosomal storage disorder characterized by the progressive accumulation of intralysosomal cystine and subsequent organ and tissue damage. The kidneys are the first and most severely impacted organ. Although cystinosis was once considered a fatal pediatric disease, patients with cystinosis are living well into adulthood with advances in medical care, including kidney transplant and early and continuous use of cysteamine therapy. This increase in life expectancy has revealed an extrarenal phenotype of cystinosis that emerges in adolescence and adulthood, affecting nearly all body systems, including the endocrine and reproductive systems. As individuals with cystinosis are planning …

Stem Cell Modeling Of Nervous System Tumors, Frank B Furnari, Corina Anastasaki, Shan Bian, Howard A Fine, Tomoyuki Koga, Lu Q Le, Fausto J Rodriguez, David H Gutmann

2020-Current year OA Pubs

Nervous system tumors, particularly brain tumors, represent the most common tumors in children and one of the most lethal tumors in adults. Despite decades of research, there are few effective therapies for these cancers. Although human nervous system tumor cells and genetically engineered mouse models have served as excellent platforms for drug discovery and preclinical testing, they have limitations with respect to accurately recapitulating important aspects of the pathobiology of spontaneously arising human tumors. For this reason, attention has turned to the deployment of human stem cell engineering involving human embryonic or induced pluripotent stem cells, in which genetic alterations …

Kenyon Collegian - February 1, 2024

The Kenyon Collegian

No abstract provided.

Life After The Pandemic: Use Of An Educational Coping Strategy Tool Kit For Healthcare Professionals, Christine Thorpe-Gilpin

Electronic Theses and Dissertations

Research has proven that acute care healthcare professionals (i.e., nurses, certified nursing assistants, and respiratory therapists have been experiencing ongoing challenges and ineffective coping mechanisms. The Toolkit for Emotional Coping for Healthcare Staff (TECHS) educational toolkit has introduced practical coping skills that could benefit healthcare workers. Using the TECHS has effectively inspired the development and usage of practical coping skills among healthcare workers. There were three tools included in the TECHS educational material to understand and manage adversity, which can be repeated for new or recurring stressful situations in a personal or team-based approach. These tools were based on cognitive-behavioral …

Family Building And Pregnancy Experiences Of Cisgender Sexual Minority Women, Diana M. Tordoff, Heidi Moseson, Sachiko Ragosta, Jen Hastings, Annesa Flentje, Matthew R. Capriotti, Micah E. Lubensky, Mitchell R. Lunn, Juno Obedin-Maliver

Faculty Research, Scholarly, and Creative Activity

BACKGROUND: Although 10% to 20% of cisgender women aged 18 to 40 years have a sexual minority identity (eg, bisexual, lesbian, and queer), there is limited research on the family building and pregnancy experiences of sexual minority cisgender women. Improving our understanding of the family building and pregnancy experiences of cisgender sexual minority women is critical for improving the perinatal health of this population. OBJECTIVE: This study aimed to compare the mode of family building, past pregnancy experiences, and future pregnancy intentions among cisgender sexual minority women by sexual orientation. STUDY DESIGN: This is an observational study which was conducted …

Operationalizing Anti-Racism Accountability With Equitable Admissions In Nursing Education Accreditation, Alicia Swartz, Denise Dawkins, Claire Valderama-Wallace, Michelle Decoux Hampton

Faculty Research, Scholarly, and Creative Activity

For decades, health professional organizations have recommended increased diversity in the workforce and education. To address persistent inequities in health care, the racial composition of the nursing workforce needs be congruent with the U.S. population. Without first addressing structural inequity in nursing education programs, the nursing profession cannot begin to address structural racism in health care. The lack of nursing student diversity is reflective of barriers in program admissions. This article is a call to nursing accreditation bodies to operationalize anti-racism to improve U.S. nursing workforce diversity by introducing accountability structures that require evidence-based holistic admission review and analysis of …

Public Acceptance Of Using Artificial Intelligence-Assisted Weight Management Apps In High-Income Southeast Asian Adults With Overweight And Obesity: A Cross-Sectional Study, Han Shi Jocelyn Chew, Palakorn Achananuparp, Palakorn Achananuparp, Nicholas W. S. Chew, Yip Han Chin, Yujia Gao, Bok Yan Jimmy So, Asim Shabbir, Ee-Peng Lim, Kee Yuan Ngiam

Research Collection School Of Computing and Information Systems

Introduction: With in increase in interest to incorporate artificial intelligence (AI) into weight management programs, we aimed to examine user perceptions of AI-based mobile apps for weight management in adults with overweight and obesity. Methods: 280 participants were recruited between May and November 2022. Participants completed a questionnaire on sociodemographic profiles, Unified Theory of Acceptance and Use of Technology 2 (UTAUT2), and Self-Regulation of Eating Behavior Questionnaire. Structural equation modeling was performed using R. Model fit was tested using maximum-likelihood generalized unweighted least squares. Associations between influencing factors were analyzed using correlation and linear regression. Results: 271 participant responses were …

Frameworks For Measuring Population Health: A Scoping Review, Sze Ling Chan, Clement Zhong Hao Ho, Nang Ei Ei Khaing, Ezra Ho, Candelyn Pong, Jia Sheng Guan, Calida Chua, Zongbin Li, Trudi Lim Wenqi, Sean Shao Wei Lam, Lian Leng Low, Choon How How

Research Collection School Of Computing and Information Systems

Introduction Many regions in the world are using the population health approach and require a means to measure the health of their population of interest. Population health frameworks provide a theoretical grounding for conceptualization of population health and therefore a logical basis for selection of indicators. The aim of this scoping review was to provide an overview and summary of the characteristics of existing population health frameworks that have been used to conceptualize the measurement of population health. Methods We used the Population, Concept and Context (PCC) framework to define eligibility criteria of frameworks. We were interested in frameworks applicable …

The Dichotomy Of Threat And Deprivation As Subtypes Of Childhood Maltreatment: Differential Functional Connectivity Patterns Of Threat And Reward Circuits In An Adult Trauma Sample, Michael T. Liuzzi, Farah Harb, Kevin Petranu, Ashley A. Huggins, E. Kate Webb, Jacklynn M. Fitzgerald, Jessica L. Krukowski, Tara A. Miskovich, Terri A. Deroon-Cassini, Christine L. Larson

Psychology Faculty Research and Publications

Background

Childhood maltreatment is associated with reduced activation of the nucleus accumbens, , a central region in the reward network, and overactivity in the amygdala, a key region in threat processing. However, the long-lasting impact of these associations in the context of later-life stress is not well understood. The current study explored the association between childhood threat and deprivation and functional connectivity of threat and reward regions in an adult trauma sample.

Methods

Trauma survivors (N = 169; mean age [SD] = 32.2 [10.3] years; female = 55.6%) were recruited from a level I trauma center. Two weeks after …

Experiences Of Racial Discrimination And Adverse Gene Expression Among Black Individuals In A Level 1 Trauma Center Sample, Claire M. Bird, E. Kate Webb, Steven W. Cole, Carissa W. Tomas, Jennifer M. Knight, Sydney C. Timmer-Murillo, Christine L. Larson, Terri A. Deroon-Cassini, Lucas Torres

Psychology Faculty Research and Publications

Up to 40% of individuals who sustain traumatic injuries are at risk for posttraumatic stress disorder (PTSD) and the conditional risk for developing PTSD is even higher for Black individuals. Exposure to racial discrimination, including at both interpersonal and structural levels, helps explain this health inequity. Yet, the relationship between racial discrimination and biological processes in the context of traumatic injury has yet to be fully explored. The current study examined whether racial discrimination is associated with a cumulative measure of biological stress, the gene expression profile conserved transcriptional response to adversity (CTRA), in Black trauma survivors. Two-weeks (T1) and …

Us Public Opinion About The Safety Of Gene Editing In The Agriculture And Medical Fields And The Amount Of Evidence Needed To Improve Opinions, Brandon R. Mcfadden, Joy N. Rumble, Kathryn A. Stofer, Kevin M. Folta

Agricultural Economics and Agribusiness Faculty Publications and Presentations

Introduction: Implementation of gene editing in agriculture and medicine hinges on public acceptance. The objectives of this study were to explore U.S. public opinion about gene editing in agricultural and medical fields and to provide more insight into the relationship between opinions about the safety of gene editing and the potential impact of evidence to improve opinions about safety.

Methods: Data were from two samples of U.S. respondents: 1,442 respondents in 2021 and 3,125 respondents in 2022. Survey respondents provided their opinions about the safety of gene editing in the agricultural and medical fields and answered questions about the number …

J Mich Dent Assoc February 2024

The Journal of the Michigan Dental Association

Every month, The Journal of the Michigan Dental Association brings news, information, and features about Michigan dentistry to our state's oral health community and the MDA's 6,200+ members. No publication reaches more Michigan dentists!

• The February issue previews the 2024 Annual Session in Lansing, highlighting 61 courses, 48 speakers, and Michigan’s largest dental exhibit hall
• A Feature article on The MDA Member Assistance Program: Real Help When You Need It
• News You Need, including The MDA announcement of John Tramontana as the new CEO/executive director
• The MDA Student Debt Resource Center
• Updates on the MDA website refresh
• Celebrating National Children’s …

Validating Indigenous Farmers’ Practice In The Management Of The Fall Armyworm Spodoptera Frugiperda (J. E. Smith) In Maize Cropping Systems In Africa, Saliou Niassy, Evanson Rigan Omuse, John Emanuel Khang’Ati, Ines Bächinger, David Mfuti Kupesa, Xavier Cheseto, Benjamin W. Mbatha, Robert S. Copeland, Samira Abuelgasim Mohamed, Mphatso Gama, Joyce Mulila Mitti, Yeneneh Belayneh, Nicolas Delabays, François Lefort, Sunday Ekesi, Sevgan Subramanian

All Peer-Reviewed Publications

Before the invasion of the fall armyworm (FAW) Spodoptera frugiperda into Africa, smallholder farmers had been using indigenous practices such as applying fish soup to plants to manage stemborer pests. Although farmers have since begun adapting this practice against FAW, no attempt has been made to scientifically evaluate this practice. Therefore, we assessed the efficacy of applying fish soup to maize plants that were artificially infested with FAW under semi-field conditions. Our results showed that foliar damage is inversely correlated with the concentration of a fish soup and sugar solution, with the highest (100%) concentration resulting in the lowest foliar …

Development Of Angiotensin Ii Type 1 Receptor Antibodies In Patients With Temporary Mechanical Circulatory Support, Maria T. Gamero, Mark Liotta, Md, Yevgeniy Brailovsky, Gregory T. Gibson, René J Alvarez, Patricia Uber, Yanping Huang, Indranee Rajapreyar

Department of Medicine Faculty Papers

Angiotensin II type 1 receptor antibodies (AT1R-Ab) are among the most investigated type of non-human leukocyte antigen antibodies in solid organ transplantation, particularly given its association with allograft dysfunction. Some prior studies have described the development of AT1R antibodies in patients with durable mechanical circulatory support (MCS); however, the role of temporary MCS in autoantibody development is still uncertain. Given that the current United Network For Organ Sharing (UNOS) allocation system prioritizes heart transplant recipients in cardiogenic shock requiring temporary MCS, we investigated the development of these antibodies in 10 patients with temporary MCS (Impella 5.5 n = 8, Intra-aortic …

Experiences And Opinions Of General Practitioners With Patient Online Record Access: An Online Survey In England, Charlotte R. Blease, Anna Kharko, Zhiyong Dong, Ray B. Jones, Gail Davidge, Maria Hagglund, Andrew Turner, Catherine Desroches, Brian Mcmillan

School of Nursing and Midwifery

Objective To describe the experiences and opinions of general practitioners (GPs) in England regarding patients having access to their full online GP health records. Design Convenience sample, online survey. Participants 400 registered GPs in England. Main outcome measures Investigators measured GPs’ experiences and opinions about online record access (ORA), including patient care and their practice. Results A total of 400 GPs from all regions of England responded. A minority (130, 33%) believed ORA was a good idea. Most GPs believed a majority of patients would worry more (364, 91%) or find their GP records more confusing than helpful (338, 85%). …

Targeting Sars-Cov-2 Main Protease (Mpro) And Human Ace-2: A Virtual Screening Of Carotenoids And Polyphenols From Tomato (Solanum Lycopersicum L.) To Combat Covid-19, Parvej Ahmad, Sahir Sultan Alvi, Inamul Hasan, M. Salman Khan

School of Medicine Publications

Background

Methods

Results

Inulin-Based Formulations As An Emerging Therapeutic Strategy For Cancer: A Comprehensive Review, Eswara Naga H K Ghali, Pranav, Subhash Chauhan, Murali M. Yallapu

School of Medicine Publications

Highlights

• Inulin is a naturally occurring prebiotic fiber with therapeutic roles.

• Inulin can act as an excellent carrier for drug delivery in cancer therapy.

• Inulin exhibits an improved therapeutic efficacy in its combination treatments.

• Inulin interventions activate phagocytosis and the TLR4 signaling pathway.

Abstract

Cancer stands as the second leading cause of death in the United States (US). Most chemotherapeutic agents exhibit severe adverse effects that are attributed to exposure of drugs to off-target tissues, posing a significant challenge in cancer therapy management. In recent years, inulin, a naturally occurring prebiotic fiber has gained substantial attention for its potential in …

Hypatia's Math: A Play, Daniel S. Helman

Journal of Humanistic Mathematics

Hypatia of Alexandria was the most famous woman mathematician of antiquity, and her story is as relevant now as it was in her day. This play tells her story. While the events in the play are based closely on extant historical texts, inspiring excerpts from classical works by Porphyry, Plotinus, Aristotle and Plato are woven into the action to further the plot and add to the classical mood. Dance and music, including an Homeric hymn, add to the artistic texture.

The Professional Journey Of A Female Mathematician: From India To The United States, Bhamini M. P. Nayar

Journal of Humanistic Mathematics

This article chronicles the journey of an immigrant female mathematician in the United States. The chronicle encompasses early training, encouragements received, road-blocks encountered and the background while growing up which shaped the core of her being. The loving, supportive and educative background she received early in life provided the strength to withstand the hurdles thrown in the path of her career advancement. These hurdles are not unique to the author; many immigrant professionals face similar situations. The purpose of the article is to bring awareness to these challenges such professionals face and how they still persevere with discipline and focus.

Reflections On Teaching Mathematics In Prisons, Matthew Junge

Journal of Humanistic Mathematics

I started teaching math in prison ten years ago during my PhD studies. Since then, I have taught for three different college-in-prison programs across the country. The goal of this piece is to communicate my experiences with the hopes of encouraging more mathematicians to get involved.

Undergraduate Mathematics Students Question And Critique Society Through Mathematical Modeling, Will Tidwell, Amy Bennett

Journal of Humanistic Mathematics

Mathematics can be used as a tool to question and critique society and, in doing so, give us more information about the world around us and how it operates. This however, is not a common perspective that is conveyed to students during their undergraduate mathematics coursework. This paper contributes to the understanding of how undergraduate mathematics students question and critique society via mathematical modeling tasks. In two courses at two universities, 27 mathematics majors and secondary preservice teachers engaged in the modeling process situated in authentic contexts to learn specific concepts and make mathematical connections across domains and disciplines. Both …

Mathematicians Going East, Pasha Zusmanovich

Journal of Humanistic Mathematics

I survey emigration of mathematicians from Europe, before and during WWII, to Russia. The emigration started at the end of 1920s, the time of “Great Break”, and accelerated in 1930s, after the introduction in Germany of the “non-Aryan laws”. Not everyone who wanted to emigrate managed to do so, and most of those who did spent a relatively short time in Russia, being murdered or deported, or fleeing the Russian regime. After 1937, the year of “Great Purge”, only a handful of emigrant mathematicians remained, and even fewer managed to leave a trace in the scientific milieu of their new …

The Automathography: A Humanistic Autobiographical Writing Assignment For Mathematics Courses, Colton Sawyer, Ron Buckmire

Journal of Humanistic Mathematics

In this article, we discuss an autobiographical writing assignment that we call an “automathography” which can be used in different types of mathematics and mathematics education courses, and by extension, in other disciplines as well. This assignment can enhance student-instructor interactions, develop student communication skills, and provide outlets for student creativity by leveraging the lived experiences of students. We have deployed the assignment in different kinds of classes (general education [service] courses and major-only seminars) at different kinds of institutions (a private, open-admission, large university on the East Coast and a private, highly selective, small liberal arts college on the …

Symposium: Gender, Health, And The Constitution: The New Gender Panic In Sport: Why State Laws Banning Transgender Athletes Are Unconstitutional, Deborah L. Brake

ConLawNOW

This essay considers the role of sport in the new gender panic of legislative activity targeting transgender individuals, which now extends into health and family governance. Sport was one of the first settings—the gateway—to ignite the current culture war on transgender youth. This analysis examines how Title IX of the Education Act of 1972, the popular law responsible for the growth of opportunities for girls and women in sports, has been mobilized in service of a broader gender agenda. Far from providing a persuasive justification for the state laws banning transgender girls from girls’ sports, Title IX, properly understood, supports …

A Matter Of Principle: Why The Ministerial Exception Categorically Bars Ministers From Bringing Hostile Work Environment Claims Against Their Religious Employers, Joshua B. Davis

Liberty University Law Review

Rooted in the First Amendment, the ministerial exception represents a general principle of law that has existed at least since the Magna Carta: the church autonomy doctrine. The ministerial exception reflects the church autonomy doctrine by recognizing a religious institution’s absolute right to select and control its ministers. Born in 1972 and receiving Supreme Court recognition in 2012, the ministerial exception’s application to most Title VII employment discrimination claims is unquestioned. But the ministerial exception’s application to hostile work environment claims, which arise from employment discrimination statutes like Title VII, is unclear.

The Supreme Court of the United States has …

Fulton'S Answer: State Constitutional Rejections Of Employment Division V. Smith As A Practical Model For The Restoration Of The Free Exercise Clause, Nathan Moelker

Liberty University Law Review

The Supreme Court’s 1990 decision in Employment Division v. Smith redefined its approach to cases under the Free Exercise Clause of the First Amendment. Many have criticized that approach and questioned its validity in the three decades since it was adopted. In Fulton v. City of Philadelphia, the Court again considered Smith’s flaws, but declined to overrule it, instead evading the Smith standard by clarifying an exception to its purportedly bright-line rule. While multiple Justices acknowledged and largely accepted the reasons that scholars continue to denounce Smith, a majority did not agree that it was time to …

Human Zoo Healthcare At The 1904 World’S Fair, Angel Blake

Undergraduate Research Symposium

Human Zoo Healthcare at the 1904 World’s Fair

Were precautions taken or put into place for the Human Zoo performers at the 1904 World’s Fair? This topic has been overlooked and understudied by historians, there are few articles written and we do not know the true death toll which shows the racism towards these indigenous peoples. The research for this project was conducted at the State Historical Society of Missouri, the St. Louis Mercantile Library, Newspapers.com, Archives.com, St. Louis Public Library, and the Missouri Historical Society, including research on primary sources such as official World’s Fair committee meeting minutes, hospital …

Hvaldimir: Russian Beluga Spy Whale, John Granicke

Undergraduate Research Symposium

In April of 2019, a beluga whale was found off the coast of Norway. The whale’s presence there is perplexing, as beluga whales are not often seen in the area. What is even more strange is the fact that the whale was wearing a mysterious harness and seemed to be tame. Nobody has officially claimed ownership of the whale, and nobody really knows why the whale is in Norway. Most importantly however, nobody knows what the whale's real mission is. Conspiracy theorists have proposed that the whale, dubbed Hvaldimir, is a trained Russian spy who escaped and abandoned his mission. …

The Roaring Lion Of Berlin: The Life, Thought, And Influence Of Eugen Dühring, Arden Roy

Undergraduate Research Symposium

The life and influence of 19th-century German polymath Eugen Dühring remain but a mere footnote in the history of ideas, being primarily relegated to the status of little more than a theoretical rival to Marxism in the German socialist movement and the occasional object of Freidrich Nietzsche's rhetorical flogging. Despite the current consensus on the subject, Eugen Dühring was a scholar of vast, remarkable learnedness, contributing greatly to philosophy, economics, and the natural sciences. The aim of this talk will be to clear the fog surrounding the life and work of the controversial blind scholar and give an account of …

Hope For The Unhoused: Medical Treatment Access And Retention Among Unhoused Individuals With Opioid Use Disorder In The St. Louis Region, Allison Token

Undergraduate Research Symposium

Medical treatment for Opioid Use Disorder (MOUD) can be highly effective, but may be particularly difficult to access among individuals who are unhoused. This study investigated how experiencing insecure housing affects the receipt of and retention rates of MOUD among participants in the St. Louis region’s Engaging Patients in Care Coordination (EPICC)—a peer-based program designed to connect people with evidence-based OUD treatment. We hypothesized EPICC clients who were unhoused received MOUD less often than clients who were housed, and that EPICC clients who were unhoused were retained in treatment for shorter periods of time than EPICC clients who were housed. …